-- dump date 20140620_032307 -- class Genbank::misc_feature -- table misc_feature_note -- id note 243090000001 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 243090000002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090000003 ATP binding site [chemical binding]; other site 243090000004 putative Mg++ binding site [ion binding]; other site 243090000005 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090000006 nucleotide binding region [chemical binding]; other site 243090000007 ATP-binding site [chemical binding]; other site 243090000008 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 243090000009 Protein of unknown function (DUF1589); Region: DUF1589; pfam07628 243090000010 Protein of unknown function (DUF1589); Region: DUF1589; pfam07628 243090000011 Protein of unknown function (DUF1589); Region: DUF1589; pfam07628 243090000012 Protein of unknown function (DUF1589); Region: DUF1589; pfam07628 243090000013 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 243090000014 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090000015 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090000016 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 243090000017 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090000018 Cytochrome c; Region: Cytochrom_C; cl11414 243090000019 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 243090000020 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243090000021 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 243090000022 Integrase core domain; Region: rve; pfam00665 243090000023 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 243090000024 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 243090000025 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 243090000026 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090000027 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243090000028 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243090000029 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090000030 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090000031 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 243090000032 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090000033 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 243090000034 putative active site [active] 243090000035 putative metal binding site [ion binding]; other site 243090000036 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243090000037 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243090000038 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 243090000039 putative active site [active] 243090000040 putative metal binding site [ion binding]; other site 243090000041 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090000042 Ribosomal L37ae protein family; Region: Ribosomal_L37ae; cl19284 243090000043 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 243090000044 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090000045 cosmid pircos-a3a12/ cosmid pircos-a1d04 joining point 243090000046 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090000047 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090000048 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090000049 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090000050 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090000051 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090000052 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090000053 Trp docking motif [polypeptide binding]; other site 243090000054 active site 243090000055 PQQ-like domain; Region: PQQ_2; pfam13360 243090000056 arylsulfatase; Provisional; Region: PRK13759 243090000057 Sulfatase; Region: Sulfatase; pfam00884 243090000058 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090000059 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090000060 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090000061 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 243090000062 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243090000063 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 243090000064 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243090000065 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090000066 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243090000067 Walker A motif; other site 243090000068 ATP binding site [chemical binding]; other site 243090000069 Walker B motif; other site 243090000070 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090000071 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090000072 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090000073 Predicted metalloprotease [General function prediction only]; Region: COG2321 243090000074 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 243090000075 Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893 243090000076 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 243090000077 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 243090000078 ECF sigma factor; Region: Sigma70_ECF; pfam07638 243090000079 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090000080 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090000081 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090000082 active site 243090000083 ATP binding site [chemical binding]; other site 243090000084 substrate binding site [chemical binding]; other site 243090000085 activation loop (A-loop); other site 243090000086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090000087 TPR motif; other site 243090000088 binding surface 243090000089 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 243090000090 active site 243090000091 putative substrate binding region [chemical binding]; other site 243090000092 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090000093 HlyD family secretion protein; Region: HlyD; pfam00529 243090000094 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243090000095 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090000096 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243090000097 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090000098 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 243090000099 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 243090000100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090000101 nucleotide binding region [chemical binding]; other site 243090000102 ATP-binding site [chemical binding]; other site 243090000103 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243090000104 Outer membrane efflux protein; Region: OEP; pfam02321 243090000105 Outer membrane efflux protein; Region: OEP; pfam02321 243090000106 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 243090000107 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 243090000108 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 243090000109 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 243090000110 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000111 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000112 Ca2+ binding site [ion binding]; other site 243090000113 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000114 Ca2+ binding site [ion binding]; other site 243090000115 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000116 Ca2+ binding site [ion binding]; other site 243090000117 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000118 Ca2+ binding site [ion binding]; other site 243090000119 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000120 Ca2+ binding site [ion binding]; other site 243090000121 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000122 Ca2+ binding site [ion binding]; other site 243090000123 cosmid pircos-a1d04/ cosmid pircos-b1h08 joining point 243090000124 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243090000125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090000126 putative active site [active] 243090000127 heme pocket [chemical binding]; other site 243090000128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090000129 dimer interface [polypeptide binding]; other site 243090000130 phosphorylation site [posttranslational modification] 243090000131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090000132 ATP binding site [chemical binding]; other site 243090000133 Mg2+ binding site [ion binding]; other site 243090000134 G-X-G motif; other site 243090000135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090000136 active site 243090000137 phosphorylation site [posttranslational modification] 243090000138 intermolecular recognition site; other site 243090000139 dimerization interface [polypeptide binding]; other site 243090000140 Hpt domain; Region: Hpt; pfam01627 243090000141 putative binding surface; other site 243090000142 active site 243090000143 Hpt domain; Region: Hpt; pfam01627 243090000144 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 243090000145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090000146 active site 243090000147 phosphorylation site [posttranslational modification] 243090000148 intermolecular recognition site; other site 243090000149 dimerization interface [polypeptide binding]; other site 243090000150 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243090000151 Zn2+ binding site [ion binding]; other site 243090000152 Mg2+ binding site [ion binding]; other site 243090000153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090000154 S-adenosylmethionine binding site [chemical binding]; other site 243090000155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 243090000156 Transposase; Region: HTH_Tnp_1; cl17663 243090000157 putative transposase OrfB; Reviewed; Region: PHA02517 243090000158 Integrase core domain; Region: rve; pfam00665 243090000159 Integrase core domain; Region: rve_3; pfam13683 243090000160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243090000161 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 243090000162 Transposase; Region: HTH_Tnp_1; cl17663 243090000163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 243090000164 putative transposase OrfB; Reviewed; Region: PHA02517 243090000165 HTH-like domain; Region: HTH_21; pfam13276 243090000166 Integrase core domain; Region: rve; pfam00665 243090000167 Integrase core domain; Region: rve_3; pfam13683 243090000168 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243090000169 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243090000170 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243090000171 Outer membrane efflux protein; Region: OEP; pfam02321 243090000172 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090000173 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090000174 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090000175 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243090000176 MMPL family; Region: MMPL; cl14618 243090000177 MMPL family; Region: MMPL; cl14618 243090000178 Phosphate-selective porin O and P; Region: Porin_O_P; cl19535 243090000179 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000180 Sulfatase; Region: Sulfatase; pfam00884 243090000181 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000182 Sulfatase; Region: Sulfatase; pfam00884 243090000183 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090000184 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090000185 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243090000186 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 243090000187 active site 243090000188 catalytic tetrad [active] 243090000189 cosmid pircos-b1h08/ cosmid pircos-c1d12 joining point 243090000190 Protein of unknown function (DUF1586); Region: DUF1586; pfam07625 243090000191 TIGR03545 family protein; Region: TIGR03545 243090000192 TIGR03546 family protein; Region: TIGR03546 243090000193 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090000194 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090000195 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090000196 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090000197 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 243090000198 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 243090000199 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 243090000200 active site 243090000201 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090000202 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090000203 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090000204 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090000205 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243090000206 histidyl-tRNA synthetase; Region: hisS; TIGR00442 243090000207 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 243090000208 dimer interface [polypeptide binding]; other site 243090000209 motif 1; other site 243090000210 active site 243090000211 motif 2; other site 243090000212 motif 3; other site 243090000213 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 243090000214 anticodon binding site; other site 243090000215 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 243090000216 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 243090000217 Formyltetrahydrofolate hydrolase [Nucleotide transport and metabolism]; Region: PurU; COG0788 243090000218 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 243090000219 active site 243090000220 substrate binding site [chemical binding]; other site 243090000221 cosubstrate binding site; other site 243090000222 catalytic site [active] 243090000223 Nuclease N terminal; Region: Nuc_N; pfam14448 243090000224 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 243090000225 Zinc ribbon domain; Region: Zn-ribbon_8; pfam09723 243090000226 TM2 domain; Region: TM2; pfam05154 243090000227 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090000228 cosmid pircos-c1d12/ cosmid pircos-d2e11 joining point 243090000229 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243090000230 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243090000231 Walker A/P-loop; other site 243090000232 ATP binding site [chemical binding]; other site 243090000233 Q-loop/lid; other site 243090000234 ABC transporter signature motif; other site 243090000235 Walker B; other site 243090000236 D-loop; other site 243090000237 H-loop/switch region; other site 243090000238 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 243090000239 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 243090000240 oligomerisation interface [polypeptide binding]; other site 243090000241 mobile loop; other site 243090000242 roof hairpin; other site 243090000243 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 243090000244 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 243090000245 putative active site [active] 243090000246 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 243090000247 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243090000248 Zn2+ binding site [ion binding]; other site 243090000249 Mg2+ binding site [ion binding]; other site 243090000250 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 243090000251 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243090000252 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243090000253 active site 243090000254 hypothetical protein; Provisional; Region: PRK07233 243090000255 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243090000256 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 243090000257 GTP binding site; other site 243090000258 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 243090000259 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 243090000260 dimer interface [polypeptide binding]; other site 243090000261 putative functional site; other site 243090000262 putative MPT binding site; other site 243090000263 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 243090000264 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 243090000265 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090000266 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 243090000267 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243090000268 minor groove reading motif; other site 243090000269 helix-hairpin-helix signature motif; other site 243090000270 substrate binding pocket [chemical binding]; other site 243090000271 active site 243090000272 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 243090000273 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 243090000274 DNA binding and oxoG recognition site [nucleotide binding] 243090000275 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 243090000276 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 243090000277 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 243090000278 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 243090000279 Malic enzyme, N-terminal domain; Region: malic; pfam00390 243090000280 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 243090000281 putative NAD(P) binding site [chemical binding]; other site 243090000282 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 243090000283 Acyl transferase domain; Region: Acyl_transf_1; cl08282 243090000284 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243090000285 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 243090000286 NAD(P) binding site [chemical binding]; other site 243090000287 homotetramer interface [polypeptide binding]; other site 243090000288 homodimer interface [polypeptide binding]; other site 243090000289 active site 243090000290 acyl carrier protein; Provisional; Region: acpP; PRK00982 243090000291 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 243090000292 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243090000293 dimer interface [polypeptide binding]; other site 243090000294 active site 243090000295 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 243090000296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090000297 active site 243090000298 phosphorylation site [posttranslational modification] 243090000299 intermolecular recognition site; other site 243090000300 dimerization interface [polypeptide binding]; other site 243090000301 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243090000302 DNA binding residues [nucleotide binding] 243090000303 dimerization interface [polypeptide binding]; other site 243090000304 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090000305 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090000306 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243090000307 active site 243090000308 cosmid pircos-d2e11/ cosmid pircos-b2f07 joining point 243090000309 YHS domain; Region: YHS; pfam04945 243090000310 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 243090000311 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243090000312 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 243090000313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243090000314 motif II; other site 243090000315 Transposase IS200 like; Region: Y1_Tnp; cl00848 243090000316 Domain of unknown function DUF77; Region: DUF77; pfam01910 243090000317 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 243090000318 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243090000319 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 243090000320 active site 243090000321 catalytic triad [active] 243090000322 oxyanion hole [active] 243090000323 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 243090000324 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 243090000325 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 243090000326 dimer interface [polypeptide binding]; other site 243090000327 [2Fe-2S] cluster binding site [ion binding]; other site 243090000328 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000329 Sulfatase; Region: Sulfatase; pfam00884 243090000330 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000331 Sulfatase; Region: Sulfatase; pfam00884 243090000332 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 243090000333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090000334 S-adenosylmethionine binding site [chemical binding]; other site 243090000335 Protein of unknown function (DUF3419); Region: DUF3419; pfam11899 243090000336 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 243090000337 putative active site [active] 243090000338 putative metal binding site [ion binding]; other site 243090000339 Alginate export; Region: Alginate_exp; pfam13372 243090000340 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 243090000341 NMT1-like family; Region: NMT1_2; pfam13379 243090000342 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 243090000343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243090000344 dimer interface [polypeptide binding]; other site 243090000345 conserved gate region; other site 243090000346 putative PBP binding loops; other site 243090000347 ABC-ATPase subunit interface; other site 243090000348 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 243090000349 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 243090000350 Walker A/P-loop; other site 243090000351 ATP binding site [chemical binding]; other site 243090000352 Q-loop/lid; other site 243090000353 ABC transporter signature motif; other site 243090000354 Walker B; other site 243090000355 D-loop; other site 243090000356 H-loop/switch region; other site 243090000357 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 243090000358 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 243090000359 Walker A/P-loop; other site 243090000360 ATP binding site [chemical binding]; other site 243090000361 Q-loop/lid; other site 243090000362 ABC transporter signature motif; other site 243090000363 Walker B; other site 243090000364 D-loop; other site 243090000365 H-loop/switch region; other site 243090000366 S-formylglutathione hydrolase; Region: PLN02442 243090000367 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 243090000368 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 243090000369 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 243090000370 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 243090000371 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 243090000372 [4Fe-4S] binding site [ion binding]; other site 243090000373 molybdopterin cofactor binding site; other site 243090000374 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 243090000375 molybdopterin cofactor binding site; other site 243090000376 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 243090000377 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243090000378 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 243090000379 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243090000380 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243090000381 sulfite reductase; Provisional; Region: PRK06214 243090000382 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 243090000383 FAD binding pocket [chemical binding]; other site 243090000384 FAD binding motif [chemical binding]; other site 243090000385 catalytic residues [active] 243090000386 NAD binding pocket [chemical binding]; other site 243090000387 phosphate binding motif [ion binding]; other site 243090000388 beta-alpha-beta structure motif; other site 243090000389 cosmid pircos-b2f07/ cosmid pircos-b2f12 joining point 243090000390 Protein of unknown function (DUF1556); Region: DUF1556; pfam07590 243090000391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243090000392 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; cl19470 243090000393 acyl-CoA synthetase; Validated; Region: PRK05850 243090000394 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 243090000395 acyl-activating enzyme (AAE) consensus motif; other site 243090000396 active site 243090000397 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 243090000398 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 243090000399 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 243090000400 substrate-cofactor binding pocket; other site 243090000401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090000402 catalytic residue [active] 243090000403 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 243090000404 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090000405 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 243090000406 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 243090000407 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243090000408 motif II; other site 243090000409 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 243090000410 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090000411 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090000412 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090000413 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090000414 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090000415 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090000416 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090000417 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 243090000418 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 243090000419 active site 243090000420 dimer interface [polypeptide binding]; other site 243090000421 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 243090000422 dimer interface [polypeptide binding]; other site 243090000423 active site 243090000424 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 243090000425 arylsulfatase; Provisional; Region: PRK13759 243090000426 Sulfatase; Region: Sulfatase; pfam00884 243090000427 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000428 Sulfatase; Region: Sulfatase; pfam00884 243090000429 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 243090000430 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 243090000431 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 243090000432 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 243090000433 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 243090000434 active site 243090000435 EamA-like transporter family; Region: EamA; cl17759 243090000436 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243090000437 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090000438 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090000439 active site 243090000440 ATP binding site [chemical binding]; other site 243090000441 substrate binding site [chemical binding]; other site 243090000442 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090000443 substrate binding site [chemical binding]; other site 243090000444 activation loop (A-loop); other site 243090000445 activation loop (A-loop); other site 243090000446 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 243090000447 active site 243090000448 dimerization interface [polypeptide binding]; other site 243090000449 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 243090000450 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090000451 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090000452 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090000453 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090000454 cosmid pircos-b2f12/ cosmid pircos-b2f01 joining point 243090000455 Cytochrome c; Region: Cytochrom_C; cl11414 243090000456 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 243090000457 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 243090000458 active site 243090000459 catalytic residues [active] 243090000460 DNA binding site [nucleotide binding] 243090000461 Int/Topo IB signature motif; other site 243090000462 Protein of unknown function (DUF1580); Region: DUF1580; pfam07618 243090000463 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50; Region: FTA4; pfam13093 243090000464 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243090000465 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243090000466 active site 243090000467 metal binding site [ion binding]; metal-binding site 243090000468 putative RNA ligase; Region: PHA02142 243090000469 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 243090000470 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 243090000471 DNA binding residues [nucleotide binding] 243090000472 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 243090000473 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 243090000474 Protein of unknown function (DUF3780); Region: DUF3780; pfam12635 243090000475 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 243090000476 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 243090000477 Predicted ATPase [General function prediction only]; Region: COG4637 243090000478 AAA domain; Region: AAA_23; pfam13476 243090000479 Walker A/P-loop; other site 243090000480 ATP binding site [chemical binding]; other site 243090000481 AAA domain; Region: AAA_21; pfam13304 243090000482 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 243090000483 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 243090000484 PLD-like domain; Region: PLDc_2; pfam13091 243090000485 putative active site [active] 243090000486 catalytic site [active] 243090000487 DEAD-like helicases superfamily; Region: DEXDc; smart00487 243090000488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090000489 ATP binding site [chemical binding]; other site 243090000490 putative Mg++ binding site [ion binding]; other site 243090000491 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090000492 nucleotide binding region [chemical binding]; other site 243090000493 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 243090000494 ATP-binding site [chemical binding]; other site 243090000495 Divergent AAA domain; Region: AAA_4; pfam04326 243090000496 Integrase core domain; Region: rve_3; cl15866 243090000497 Integrase core domain; Region: rve; pfam00665 243090000498 Protein of unknown function (DUF1581); Region: DUF1581; pfam07619 243090000499 Protein of unknown function (DUF1583); Region: DUF1583; pfam07622 243090000500 Protein of unknown function (DUF1581); Region: DUF1581; pfam07619 243090000501 Protein of unknown function (DUF1583); Region: DUF1583; pfam07622 243090000502 Protein of unknown function (DUF1581); Region: DUF1581; pfam07619 243090000503 Protein of unknown function (DUF1583); Region: DUF1583; pfam07622 243090000504 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090000505 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090000506 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090000507 DNA binding residues [nucleotide binding] 243090000508 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090000509 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090000510 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090000511 calmodulin; Provisional; Region: PTZ00184 243090000512 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090000513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090000514 Walker A motif; other site 243090000515 ATP binding site [chemical binding]; other site 243090000516 Walker B motif; other site 243090000517 arginine finger; other site 243090000518 Protein of unknown function DUF58; Region: DUF58; pfam01882 243090000519 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243090000520 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 243090000521 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090000522 metal ion-dependent adhesion site (MIDAS); other site 243090000523 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 243090000524 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 243090000525 cosmid pircos-b2f01/ cosmid pircos-a3f07 joining point 243090000526 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 243090000527 Brain acid soluble protein 1 (BASP1 protein); Region: BASP1; pfam05466 243090000528 Protein of unknown function (DUF2967); Region: DUF2967; pfam11179 243090000529 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090000530 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090000531 Transcriptional regulators [Transcription]; Region: PurR; COG1609 243090000532 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 243090000533 putative ligand binding site [chemical binding]; other site 243090000534 putative dimerization interface [polypeptide binding]; other site 243090000535 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243090000536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090000537 Trehalose utilisation; Region: ThuA; pfam06283 243090000538 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090000539 Photosystem I reaction centre subunit N (PSAN or PSI-N); Region: PsaN; cl05182 243090000540 Cytochrome c; Region: Cytochrom_C; cl11414 243090000541 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 243090000542 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 243090000543 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 243090000544 active site 243090000545 hydrophilic channel; other site 243090000546 dimerization interface [polypeptide binding]; other site 243090000547 catalytic residues [active] 243090000548 active site lid [active] 243090000549 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090000550 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 243090000551 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 243090000552 putative MPT binding site; other site 243090000553 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243090000554 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090000555 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090000556 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090000557 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090000558 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 243090000559 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 243090000560 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 243090000561 catalytic site [active] 243090000562 active site 243090000563 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 243090000564 cosmid pircos-a3f07/ cosmid pircos-b2d11 joining point 243090000565 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 243090000566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090000567 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090000568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090000569 binding surface 243090000570 TPR motif; other site 243090000571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 243090000572 YCII-related domain; Region: YCII; cl00999 243090000573 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 243090000574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 243090000575 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 243090000576 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 243090000577 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090000578 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 243090000579 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243090000580 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 243090000581 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090000582 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 243090000583 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 243090000584 putative ligand binding site [chemical binding]; other site 243090000585 putative catalytic site [active] 243090000586 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090000587 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090000588 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090000589 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090000590 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090000591 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090000592 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090000593 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243090000594 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243090000595 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243090000596 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243090000597 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243090000598 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243090000599 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243090000600 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243090000601 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243090000602 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000603 Sulfatase; Region: Sulfatase; pfam00884 243090000604 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000605 Sulfatase; Region: Sulfatase; pfam00884 243090000606 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090000607 Abhydrolase family; Region: Abhydrolase_7; pfam12715 243090000608 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090000609 Abhydrolase family; Region: Abhydrolase_7; pfam12715 243090000610 cosmid pircos-b2d11/ cosmid pircos-a3g01 joining point 243090000611 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090000612 active site 243090000613 PQQ-like domain; Region: PQQ_2; pfam13360 243090000614 Trp docking motif [polypeptide binding]; other site 243090000615 SLA1 homology domain 1, SHD1; Region: SHD1; pfam03983 243090000616 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090000617 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 243090000618 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090000619 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090000620 structural tetrad; other site 243090000621 ECF sigma factor; Region: Sigma70_ECF; pfam07638 243090000622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 243090000623 DNA binding residues [nucleotide binding] 243090000624 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243090000625 EF hand; Region: EF-hand_5; pfam13202 243090000626 Protein kinase domain; Region: Pkinase; pfam00069 243090000627 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090000628 active site 243090000629 ATP binding site [chemical binding]; other site 243090000630 substrate binding site [chemical binding]; other site 243090000631 activation loop (A-loop); other site 243090000632 TPR repeat; Region: TPR_11; pfam13414 243090000633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090000634 TPR motif; other site 243090000635 binding surface 243090000636 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090000637 Animal haem peroxidase; Region: An_peroxidase; pfam03098 243090000638 Uncharacterized family of heme peroxidases, mostly bacterial; Region: peroxinectin_like_bacterial; cd09822 243090000639 putative heme binding site [chemical binding]; other site 243090000640 putative substrate binding site [chemical binding]; other site 243090000641 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090000642 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 243090000643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090000644 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090000645 DNA binding residues [nucleotide binding] 243090000646 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090000647 PQQ-like domain; Region: PQQ_2; pfam13360 243090000648 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090000649 active site 243090000650 Trp docking motif [polypeptide binding]; other site 243090000651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090000652 active site 243090000653 phosphorylation site [posttranslational modification] 243090000654 intermolecular recognition site; other site 243090000655 dimerization interface [polypeptide binding]; other site 243090000656 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243090000657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090000658 putative active site [active] 243090000659 heme pocket [chemical binding]; other site 243090000660 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243090000661 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090000662 putative active site [active] 243090000663 heme pocket [chemical binding]; other site 243090000664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090000665 heme pocket [chemical binding]; other site 243090000666 putative active site [active] 243090000667 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243090000668 hypothetical protein; Provisional; Region: PRK13559 243090000669 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090000670 putative active site [active] 243090000671 heme pocket [chemical binding]; other site 243090000672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090000673 dimer interface [polypeptide binding]; other site 243090000674 phosphorylation site [posttranslational modification] 243090000675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090000676 ATP binding site [chemical binding]; other site 243090000677 Mg2+ binding site [ion binding]; other site 243090000678 G-X-G motif; other site 243090000679 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090000680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090000681 active site 243090000682 phosphorylation site [posttranslational modification] 243090000683 intermolecular recognition site; other site 243090000684 dimerization interface [polypeptide binding]; other site 243090000685 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090000686 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090000687 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 243090000688 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243090000689 EcsC protein family; Region: EcsC; pfam12787 243090000690 monoglyceride lipase; Provisional; Region: PHA02857 243090000691 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243090000692 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 243090000693 Na binding site [ion binding]; other site 243090000694 L-rhamnose isomerase; Provisional; Region: PRK01076 243090000695 transcriptional activator RhaS; Provisional; Region: PRK13503 243090000696 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 243090000697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090000698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090000699 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 243090000700 intersubunit interface [polypeptide binding]; other site 243090000701 active site 243090000702 Zn2+ binding site [ion binding]; other site 243090000703 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 243090000704 intersubunit interface [polypeptide binding]; other site 243090000705 active site 243090000706 Zn2+ binding site [ion binding]; other site 243090000707 cosmid pircos-a3g01/ cosmid pircos-c1g07 joining point 243090000708 aldehyde dehydrogenase family 2 member; Region: PLN02466 243090000709 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243090000710 NAD(P) binding site [chemical binding]; other site 243090000711 catalytic residues [active] 243090000712 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000713 Sulfatase; Region: Sulfatase; pfam00884 243090000714 Bacterial Ig-like domain; Region: Big_5; pfam13205 243090000715 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000716 Sulfatase; Region: Sulfatase; pfam00884 243090000717 Transposase IS200 like; Region: Y1_Tnp; cl00848 243090000718 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090000719 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000720 Sulfatase; Region: Sulfatase; pfam00884 243090000721 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 243090000722 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 243090000723 Transposase; Region: HTH_Tnp_1; cl17663 243090000724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 243090000725 putative transposase OrfB; Reviewed; Region: PHA02517 243090000726 HTH-like domain; Region: HTH_21; pfam13276 243090000727 Integrase core domain; Region: rve; pfam00665 243090000728 Integrase core domain; Region: rve_3; pfam13683 243090000729 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000730 Sulfatase; Region: Sulfatase; pfam00884 243090000731 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 243090000732 active site 243090000733 catalytic triad [active] 243090000734 oxyanion hole [active] 243090000735 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090000736 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090000737 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 243090000738 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090000739 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090000740 PSRT; Region: PSRT; pfam07636 243090000741 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000742 Sulfatase; Region: Sulfatase; pfam00884 243090000743 Protein of unknown function (DUF1584); Region: PEGSRP; pfam07623 243090000744 arylsulfatase; Provisional; Region: PRK13759 243090000745 Sulfatase; Region: Sulfatase; pfam00884 243090000746 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090000747 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 243090000748 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090000749 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 243090000750 Cytochrome c; Region: Cytochrom_C; cl11414 243090000751 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090000752 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 243090000753 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090000754 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090000755 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 243090000756 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090000757 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090000758 active site 243090000759 PQQ-like domain; Region: PQQ_2; pfam13360 243090000760 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090000761 Trp docking motif [polypeptide binding]; other site 243090000762 active site 243090000763 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243090000764 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 243090000765 cosmid pircos-c1g07/ cosmid pircos-c1c03 joining point 243090000766 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243090000767 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 243090000768 SLBB domain; Region: SLBB; pfam10531 243090000769 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 243090000770 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243090000771 Penicillinase repressor; Region: Penicillinase_R; pfam03965 243090000772 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000773 Sulfatase; Region: Sulfatase; pfam00884 243090000774 Domain of unknown function (DUF303); Region: DUF303; pfam03629 243090000775 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000776 Sulfatase; Region: Sulfatase; pfam00884 243090000777 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 243090000778 mannose binding site [chemical binding]; other site 243090000779 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000780 Sulfatase; Region: Sulfatase; pfam00884 243090000781 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090000782 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000783 Sulfatase; Region: Sulfatase; pfam00884 243090000784 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090000785 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090000786 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090000787 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090000788 Sodium Bile acid symporter family; Region: SBF; cl19217 243090000789 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 243090000790 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 243090000791 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 243090000792 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 243090000793 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243090000794 Transposase [DNA replication, recombination, and repair]; Region: COG5433 243090000795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 243090000796 Transposase; Region: HTH_Tnp_1; cl17663 243090000797 putative transposase OrfB; Reviewed; Region: PHA02517 243090000798 Integrase core domain; Region: rve; pfam00665 243090000799 Integrase core domain; Region: rve_3; pfam13683 243090000800 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 243090000801 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 243090000802 putative active site [active] 243090000803 putative NTP binding site [chemical binding]; other site 243090000804 putative nucleic acid binding site [nucleotide binding]; other site 243090000805 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 243090000806 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243090000807 MMPL family; Region: MMPL; cl14618 243090000808 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 243090000809 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243090000810 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090000811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243090000812 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 243090000813 Autism susceptibility gene 2 protein; Region: Auts2; pfam15336 243090000814 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 243090000815 Subtilase family; Region: Peptidase_S8; pfam00082 243090000816 active site 243090000817 catalytic residues [active] 243090000818 cosmid pircos-c1c03/ cosmid pircos-b1c05 joining point 243090000819 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090000820 Cadherin repeat-like domain; Region: CA_like; cl15786 243090000821 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 243090000822 YTV; Region: YTV; pfam07639 243090000823 YTV; Region: YTV; pfam07639 243090000824 L-lactate dehydrogenase-like enzymes; Region: LDH_like; cd00300 243090000825 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 243090000826 NAD(P) binding site [chemical binding]; other site 243090000827 dimer interface [polypeptide binding]; other site 243090000828 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243090000829 substrate binding site [chemical binding]; other site 243090000830 Rabaptin-like protein; Region: Rab5-bind; pfam09311 243090000831 Protein of unknown function (DUF2810); Region: DUF2810; cl08159 243090000832 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 243090000833 Helix-turn-helix domain; Region: HTH_17; cl17695 243090000834 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090000835 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090000836 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090000837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090000838 binding surface 243090000839 TPR motif; other site 243090000840 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090000841 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090000842 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090000843 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243090000844 heme-binding residues [chemical binding]; other site 243090000845 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 243090000846 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 243090000847 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090000848 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000849 Ca2+ binding site [ion binding]; other site 243090000850 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000851 Ca2+ binding site [ion binding]; other site 243090000852 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000853 Ca2+ binding site [ion binding]; other site 243090000854 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000855 Ca2+ binding site [ion binding]; other site 243090000856 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000857 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000858 Ca2+ binding site [ion binding]; other site 243090000859 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000860 Ca2+ binding site [ion binding]; other site 243090000861 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000862 Ca2+ binding site [ion binding]; other site 243090000863 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000864 Ca2+ binding site [ion binding]; other site 243090000865 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000866 Ca2+ binding site [ion binding]; other site 243090000867 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000868 Ca2+ binding site [ion binding]; other site 243090000869 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000870 Ca2+ binding site [ion binding]; other site 243090000871 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000872 Ca2+ binding site [ion binding]; other site 243090000873 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000874 Ca2+ binding site [ion binding]; other site 243090000875 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000876 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090000877 Ca2+ binding site [ion binding]; other site 243090000878 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090000879 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 243090000880 dockerin binding interface [polypeptide binding]; other site 243090000881 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090000882 cosmid pircos-b1c05/ cosmid pircos-a1g03 joining point 243090000883 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 243090000884 dockerin binding interface [polypeptide binding]; other site 243090000885 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090000886 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090000887 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090000888 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090000889 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 243090000890 Ca2+ binding site [ion binding]; other site 243090000891 FecR protein; Region: FecR; pfam04773 243090000892 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090000893 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 243090000894 DNA binding residues [nucleotide binding] 243090000895 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 243090000896 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243090000897 active site 243090000898 DNA binding site [nucleotide binding] 243090000899 Int/Topo IB signature motif; other site 243090000900 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 243090000901 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 243090000902 Putative transposase; Region: Y2_Tnp; pfam04986 243090000903 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243090000904 active site 243090000905 Int/Topo IB signature motif; other site 243090000906 DNA binding site [nucleotide binding] 243090000907 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 243090000908 Putative transposase; Region: Y2_Tnp; pfam04986 243090000909 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 243090000910 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 243090000911 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 243090000912 amino acid transporter; Region: 2A0306; TIGR00909 243090000913 Pathogenicity factor; Region: AvrE; pfam11725 243090000914 Protein of unknown function (DUF1596); Region: DUF1596; pfam07641 243090000915 Protein of unknown function (DUF1596); Region: DUF1596; pfam07641 243090000916 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 243090000917 Putative transposase; Region: Y2_Tnp; pfam04986 243090000918 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243090000919 active site 243090000920 DNA binding site [nucleotide binding] 243090000921 Int/Topo IB signature motif; other site 243090000922 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243090000923 Protein of unknown function (DUF1596); Region: DUF1596; pfam07641 243090000924 Protein of unknown function (DUF1596); Region: DUF1596; pfam07641 243090000925 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 243090000926 Patatin-like phospholipase; Region: Patatin; pfam01734 243090000927 active site 243090000928 nucleophile elbow; other site 243090000929 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090000930 Sulfatase; Region: Sulfatase; pfam00884 243090000931 PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate...; Region: PAF_acetylesterase_like; cd01820 243090000932 active site 243090000933 catalytic triad [active] 243090000934 oxyanion hole [active] 243090000935 specificity pocket; other site 243090000936 cosmid pircos-a1g03/ cosmid pircos-d2g04 joining point 243090000937 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 243090000938 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 243090000939 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243090000940 active site 243090000941 DNA polymerase phi; Region: DNA_pol_phi; pfam04931 243090000942 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 243090000943 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 243090000944 active site 243090000945 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 243090000946 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 243090000947 active site 243090000948 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090000949 Trp docking motif [polypeptide binding]; other site 243090000950 PQQ-like domain; Region: PQQ_2; pfam13360 243090000951 active site 243090000952 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 243090000953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243090000954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243090000955 putative substrate translocation pore; other site 243090000956 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090000957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243090000958 NAD(P) binding site [chemical binding]; other site 243090000959 active site 243090000960 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 243090000961 Dimer interface [polypeptide binding]; other site 243090000962 BRCT sequence motif; other site 243090000963 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 243090000964 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243090000965 DNA binding residues [nucleotide binding] 243090000966 TPR repeat; Region: TPR_11; pfam13414 243090000967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090000968 binding surface 243090000969 TPR motif; other site 243090000970 TPR repeat; Region: TPR_11; pfam13414 243090000971 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 243090000972 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243090000973 Zn2+ binding site [ion binding]; other site 243090000974 Mg2+ binding site [ion binding]; other site 243090000975 Uncharacterized conserved protein [Function unknown]; Region: COG4717 243090000976 AAA domain; Region: AAA_23; pfam13476 243090000977 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 243090000978 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 243090000979 active site 243090000980 metal binding site [ion binding]; metal-binding site 243090000981 DNA binding site [nucleotide binding] 243090000982 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243090000983 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090000984 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243090000985 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 243090000986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 243090000987 seryl-tRNA synthetase; Provisional; Region: PRK05431 243090000988 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 243090000989 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 243090000990 dimer interface [polypeptide binding]; other site 243090000991 active site 243090000992 motif 1; other site 243090000993 motif 2; other site 243090000994 motif 3; other site 243090000995 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 243090000996 TatD related DNase; Region: TatD_DNase; pfam01026 243090000997 active site 243090000998 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 243090000999 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 243090001000 generic binding surface II; other site 243090001001 ssDNA binding site; other site 243090001002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090001003 ATP binding site [chemical binding]; other site 243090001004 putative Mg++ binding site [ion binding]; other site 243090001005 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090001006 nucleotide binding region [chemical binding]; other site 243090001007 ATP-binding site [chemical binding]; other site 243090001008 cosmid pircos-d2g04/ cosmid pircos-a1f12 joining point 243090001009 Aspartyl protease; Region: Asp_protease_2; pfam13650 243090001010 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 243090001011 protein binding site [polypeptide binding]; other site 243090001012 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090001013 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090001014 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090001015 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 243090001016 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090001017 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090001018 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 243090001019 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 243090001020 TM-ABC transporter signature motif; other site 243090001021 adenylate kinase; Region: adk; TIGR01351 243090001022 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 243090001023 AMP-binding site [chemical binding]; other site 243090001024 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 243090001025 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 243090001026 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 243090001027 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 243090001028 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 243090001029 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090001030 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090001031 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 243090001032 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 243090001033 cosmid pircos-a1f12/ cosmid pircos-d3h10 joining point 243090001034 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 243090001035 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 243090001036 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243090001037 PSRT; Region: PSRT; pfam07636 243090001038 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090001039 Sensors of blue-light using FAD; Region: BLUF; pfam04940 243090001040 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243090001041 Outer membrane efflux protein; Region: OEP; pfam02321 243090001042 Outer membrane efflux protein; Region: OEP; pfam02321 243090001043 HlyD family secretion protein; Region: HlyD; pfam00529 243090001044 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090001045 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090001046 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 243090001047 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243090001048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243090001049 Walker A/P-loop; other site 243090001050 ATP binding site [chemical binding]; other site 243090001051 Q-loop/lid; other site 243090001052 ABC transporter signature motif; other site 243090001053 Walker B; other site 243090001054 D-loop; other site 243090001055 H-loop/switch region; other site 243090001056 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 243090001057 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 243090001058 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 243090001059 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243090001060 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 243090001061 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 243090001062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090001063 active site 243090001064 phosphorylation site [posttranslational modification] 243090001065 intermolecular recognition site; other site 243090001066 dimerization interface [polypeptide binding]; other site 243090001067 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243090001068 DNA binding residues [nucleotide binding] 243090001069 dimerization interface [polypeptide binding]; other site 243090001070 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243090001071 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243090001072 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 243090001073 ATP binding site [chemical binding]; other site 243090001074 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243090001075 Walker A motif; other site 243090001076 hexamer interface [polypeptide binding]; other site 243090001077 Walker B motif; other site 243090001078 cosmid pircos-d3h10/ cosmid pircos-d1c01 joining point 243090001079 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 243090001080 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 243090001081 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 243090001082 TadE-like protein; Region: TadE; pfam07811 243090001083 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 243090001084 TadE-like protein; Region: TadE; pfam07811 243090001085 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090001086 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090001087 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243090001088 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243090001089 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243090001090 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 243090001091 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 243090001092 inhibitor-cofactor binding pocket; inhibition site 243090001093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090001094 catalytic residue [active] 243090001095 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243090001096 Protein of unknown function (DUF1584); Region: PEGSRP; pfam07623 243090001097 Protein of unknown function (DUF1584); Region: PEGSRP; pfam07623 243090001098 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 243090001099 Protein of unknown function (DUF1556); Region: DUF1556; pfam07590 243090001100 Putative transposase; Region: Y2_Tnp; pfam04986 243090001101 Transposase; Region: HTH_Tnp_1; cl17663 243090001102 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 243090001103 putative transposase OrfB; Reviewed; Region: PHA02517 243090001104 HTH-like domain; Region: HTH_21; pfam13276 243090001105 Integrase core domain; Region: rve; pfam00665 243090001106 Integrase core domain; Region: rve_3; pfam13683 243090001107 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 243090001108 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 243090001109 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 243090001110 Int/Topo IB signature motif; other site 243090001111 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 243090001112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090001113 Coenzyme A binding pocket [chemical binding]; other site 243090001114 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090001115 Helix-turn-helix domain; Region: HTH_38; pfam13936 243090001116 Protein of unknown function (DUF1582); Region: DUF1582; pfam07621 243090001117 arylsulfatase; Provisional; Region: PRK13759 243090001118 Sulfatase; Region: Sulfatase; cl19157 243090001119 cosmid pircos-d1c01/ cosmid pircos-b1a05 joining point 243090001120 PEP-CTERM motif; Region: VPEP; pfam07589 243090001121 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090001122 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090001123 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 243090001124 MgtE intracellular N domain; Region: MgtE_N; pfam03448 243090001125 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 243090001126 Divalent cation transporter; Region: MgtE; cl00786 243090001127 translation elongation factor P; Region: efp; TIGR00038 243090001128 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 243090001129 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 243090001130 RNA binding site [nucleotide binding]; other site 243090001131 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 243090001132 RNA binding site [nucleotide binding]; other site 243090001133 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090001134 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243090001135 FeS/SAM binding site; other site 243090001136 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 243090001137 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 243090001138 active site 243090001139 catalytic residues [active] 243090001140 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 243090001141 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243090001142 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243090001143 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 243090001144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243090001145 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 243090001146 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 243090001147 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 243090001148 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243090001149 RNA binding surface [nucleotide binding]; other site 243090001150 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 243090001151 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090001152 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090001153 WYL domain; Region: WYL; pfam13280 243090001154 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090001155 Putative phosphatase (DUF442); Region: DUF442; cl17385 243090001156 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 243090001157 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243090001158 Walker A/P-loop; other site 243090001159 ATP binding site [chemical binding]; other site 243090001160 Q-loop/lid; other site 243090001161 ABC transporter signature motif; other site 243090001162 Walker B; other site 243090001163 D-loop; other site 243090001164 H-loop/switch region; other site 243090001165 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243090001166 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 243090001167 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 243090001168 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 243090001169 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 243090001170 Domain of unknown function (DUF4456); Region: DUF4456; pfam14644 243090001171 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 243090001172 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 243090001173 BNR repeat-like domain; Region: BNR_2; pfam13088 243090001174 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243090001175 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 243090001176 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 243090001177 putative active site [active] 243090001178 putative PHP Thumb interface [polypeptide binding]; other site 243090001179 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 243090001180 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 243090001181 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 243090001182 generic binding surface II; other site 243090001183 generic binding surface I; other site 243090001184 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 243090001185 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 243090001186 FMN binding site [chemical binding]; other site 243090001187 active site 243090001188 catalytic residues [active] 243090001189 substrate binding site [chemical binding]; other site 243090001190 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 243090001191 homotrimer interaction site [polypeptide binding]; other site 243090001192 putative active site [active] 243090001193 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 243090001194 inhibitor site; inhibition site 243090001195 active site 243090001196 dimer interface [polypeptide binding]; other site 243090001197 catalytic residue [active] 243090001198 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 243090001199 active site 243090001200 FMN binding site [chemical binding]; other site 243090001201 substrate binding site [chemical binding]; other site 243090001202 putative catalytic residue [active] 243090001203 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243090001204 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243090001205 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243090001206 cosmid pircos-b1a05/ cosmid pircos-b1b01 joining point 243090001207 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 243090001208 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243090001209 Transposase [DNA replication, recombination, and repair]; Region: COG5433 243090001210 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243090001211 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 243090001212 SmpA / OmlA family; Region: SmpA_OmlA; cl19285 243090001213 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 243090001214 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090001215 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 243090001216 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090001217 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 243090001218 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243090001219 Walker A/P-loop; other site 243090001220 ATP binding site [chemical binding]; other site 243090001221 Q-loop/lid; other site 243090001222 ABC transporter signature motif; other site 243090001223 Walker B; other site 243090001224 D-loop; other site 243090001225 H-loop/switch region; other site 243090001226 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 243090001227 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 243090001228 active site 243090001229 catalytic residues [active] 243090001230 metal binding site [ion binding]; metal-binding site 243090001231 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 243090001232 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 243090001233 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 243090001234 active site 243090001235 HIGH motif; other site 243090001236 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243090001237 KMSKS motif; other site 243090001238 Zinc ribbon domain; Region: Zn-ribbon_8; cl00993 243090001239 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 243090001240 tRNA binding surface [nucleotide binding]; other site 243090001241 anticodon binding site; other site 243090001242 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 243090001243 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 243090001244 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 243090001245 nucleotide binding site [chemical binding]; other site 243090001246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243090001247 H+ Antiporter protein; Region: 2A0121; TIGR00900 243090001248 putative substrate translocation pore; other site 243090001249 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 243090001250 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243090001251 Walker A/P-loop; other site 243090001252 ATP binding site [chemical binding]; other site 243090001253 Q-loop/lid; other site 243090001254 ABC transporter signature motif; other site 243090001255 Walker B; other site 243090001256 D-loop; other site 243090001257 H-loop/switch region; other site 243090001258 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243090001259 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 243090001260 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243090001261 large tegument protein UL36; Provisional; Region: PHA03247 243090001262 cosmid pircos-b1b01/ cosmid pircos-d1g03 joining point 243090001263 PilZ domain; Region: PilZ; pfam07238 243090001264 PilZ domain; Region: PilZ; pfam07238 243090001265 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 243090001266 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 243090001267 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 243090001268 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 243090001269 TIGR02453 family protein; Region: TIGR02453 243090001270 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 243090001271 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 243090001272 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 243090001273 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 243090001274 active site 243090001275 trimer interface [polypeptide binding]; other site 243090001276 allosteric site; other site 243090001277 active site lid [active] 243090001278 hexamer (dimer of trimers) interface [polypeptide binding]; other site 243090001279 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 243090001280 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243090001281 active site 243090001282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243090001283 metal binding site [ion binding]; metal-binding site 243090001284 active site 243090001285 I-site; other site 243090001286 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 243090001287 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 243090001288 ligand binding site; other site 243090001289 oligomer interface; other site 243090001290 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 243090001291 dimer interface [polypeptide binding]; other site 243090001292 N-terminal domain interface [polypeptide binding]; other site 243090001293 sulfate 1 binding site; other site 243090001294 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 243090001295 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090001296 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090001297 protein binding site [polypeptide binding]; other site 243090001298 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090001299 protein binding site [polypeptide binding]; other site 243090001300 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 243090001301 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 243090001302 hexamer interface [polypeptide binding]; other site 243090001303 ligand binding site [chemical binding]; other site 243090001304 putative active site [active] 243090001305 NAD(P) binding site [chemical binding]; other site 243090001306 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 243090001307 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 243090001308 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 243090001309 tandem repeat interface [polypeptide binding]; other site 243090001310 oligomer interface [polypeptide binding]; other site 243090001311 active site residues [active] 243090001312 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 243090001313 O-Antigen ligase; Region: Wzy_C; pfam04932 243090001314 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 243090001315 Substrate binding site [chemical binding]; other site 243090001316 Deoxyhypusine synthase; Region: DS; cl00826 243090001317 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 243090001318 NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652 243090001319 active site 243090001320 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 243090001321 putative hydrophobic ligand binding site [chemical binding]; other site 243090001322 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 243090001323 TIGR01777 family protein; Region: yfcH 243090001324 putative NAD(P) binding site [chemical binding]; other site 243090001325 putative active site [active] 243090001326 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 243090001327 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090001328 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 243090001329 DNA binding residues [nucleotide binding] 243090001330 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 243090001331 DNA binding residues [nucleotide binding] 243090001332 B12 binding domain; Region: B12-binding_2; pfam02607 243090001333 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 243090001334 B12 binding site [chemical binding]; other site 243090001335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 243090001336 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243090001337 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 243090001338 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243090001339 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 243090001340 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 243090001341 inhibitor site; inhibition site 243090001342 active site 243090001343 dimer interface [polypeptide binding]; other site 243090001344 catalytic residue [active] 243090001345 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 243090001346 active site 243090001347 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090001348 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090001349 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090001350 cosmid pircos-d1g03/ cosmid pircos-d2a11 joining point 243090001351 NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652 243090001352 active site 243090001353 TIGR03790 family protein; Region: TIGR03790 243090001354 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 243090001355 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243090001356 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 243090001357 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243090001358 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 243090001359 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243090001360 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 243090001361 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12508 243090001362 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12504 243090001363 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 243090001364 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 243090001365 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 243090001366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090001367 binding surface 243090001368 TPR motif; other site 243090001369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090001370 binding surface 243090001371 TPR motif; other site 243090001372 PQQ-like domain; Region: PQQ_2; pfam13360 243090001373 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090001374 Trp docking motif [polypeptide binding]; other site 243090001375 active site 243090001376 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 243090001377 putative dimerization interface [polypeptide binding]; other site 243090001378 Transcriptional regulators [Transcription]; Region: PurR; COG1609 243090001379 putative ligand binding site [chemical binding]; other site 243090001380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090001381 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243090001382 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090001383 Sulfatase; Region: Sulfatase; pfam00884 243090001384 RDD family; Region: RDD; pfam06271 243090001385 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090001386 Sulfatase; Region: Sulfatase; pfam00884 243090001387 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 243090001388 Right handed beta helix region; Region: Beta_helix; pfam13229 243090001389 cosmid pircos-d2a11/ cosmid pircos-d2e09 joining point 243090001390 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 243090001391 Protein of unknown function (DUF1590); Region: DUF1590; pfam07629 243090001392 PSRT; Region: PSRT; pfam07636 243090001393 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090001394 Sulfatase; Region: Sulfatase; pfam00884 243090001395 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090001396 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090001397 Sulfatase; Region: Sulfatase; pfam00884 243090001398 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090001399 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090001400 metal ion-dependent adhesion site (MIDAS); other site 243090001401 dihydroxy-acid dehydratase; Validated; Region: PRK06131 243090001402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 243090001403 MOSC domain; Region: MOSC; pfam03473 243090001404 3-alpha domain; Region: 3-alpha; pfam03475 243090001405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090001406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090001407 ATP binding site [chemical binding]; other site 243090001408 Mg2+ binding site [ion binding]; other site 243090001409 G-X-G motif; other site 243090001410 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 243090001411 hypothetical protein; Provisional; Region: PRK08609 243090001412 active site 243090001413 primer binding site [nucleotide binding]; other site 243090001414 NTP binding site [chemical binding]; other site 243090001415 metal binding triad [ion binding]; metal-binding site 243090001416 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 243090001417 active site 243090001418 Uncharacterized conserved protein [Function unknown]; Region: COG1359 243090001419 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243090001420 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243090001421 ligand binding site [chemical binding]; other site 243090001422 flexible hinge region; other site 243090001423 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 243090001424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090001425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243090001426 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243090001427 Protein of unknown function DUF58; Region: DUF58; pfam01882 243090001428 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090001429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090001430 Walker A motif; other site 243090001431 ATP binding site [chemical binding]; other site 243090001432 Walker B motif; other site 243090001433 arginine finger; other site 243090001434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090001435 active site 243090001436 phosphorylation site [posttranslational modification] 243090001437 intermolecular recognition site; other site 243090001438 dimerization interface [polypeptide binding]; other site 243090001439 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 243090001440 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 243090001441 active site 243090001442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090001443 Coenzyme A binding pocket [chemical binding]; other site 243090001444 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243090001445 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090001446 metal ion-dependent adhesion site (MIDAS); other site 243090001447 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243090001448 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243090001449 Walker A/P-loop; other site 243090001450 ATP binding site [chemical binding]; other site 243090001451 Q-loop/lid; other site 243090001452 ABC transporter signature motif; other site 243090001453 Walker B; other site 243090001454 D-loop; other site 243090001455 H-loop/switch region; other site 243090001456 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090001457 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090001458 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090001459 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090001460 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 243090001461 putative active site [active] 243090001462 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 243090001463 active site 243090001464 catalytic triad [active] 243090001465 oxyanion hole [active] 243090001466 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 243090001467 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 243090001468 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090001469 FeS/SAM binding site; other site 243090001470 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090001471 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090001472 active site 243090001473 ATP binding site [chemical binding]; other site 243090001474 substrate binding site [chemical binding]; other site 243090001475 activation loop (A-loop); other site 243090001476 cosmid pircos-d2e09/ cosmid pircos-b1f04 joining point 243090001477 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 243090001478 active site 243090001479 catalytic residues [active] 243090001480 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 243090001481 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 243090001482 dimer interface [polypeptide binding]; other site 243090001483 active site 243090001484 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243090001485 catalytic residues [active] 243090001486 substrate binding site [chemical binding]; other site 243090001487 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090001488 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090001489 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090001490 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090001491 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090001492 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 243090001493 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243090001494 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090001495 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090001496 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243090001497 catalytic core [active] 243090001498 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 243090001499 substrate binding site [chemical binding]; other site 243090001500 hexamer interface [polypeptide binding]; other site 243090001501 metal binding site [ion binding]; metal-binding site 243090001502 Uncharacterized protein family (UPF0193); Region: UPF0193; pfam05250 243090001503 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 243090001504 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 243090001505 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243090001506 ATP-dependent DNA ligase; Validated; Region: PRK09247 243090001507 DNA ligase N terminus; Region: DNA_ligase_A_N; pfam04675 243090001508 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 243090001509 active site 243090001510 DNA binding site [nucleotide binding] 243090001511 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 243090001512 DNA binding site [nucleotide binding] 243090001513 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090001514 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090001515 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 243090001516 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090001517 ATP binding site [chemical binding]; other site 243090001518 putative Mg++ binding site [ion binding]; other site 243090001519 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090001520 nucleotide binding region [chemical binding]; other site 243090001521 ATP-binding site [chemical binding]; other site 243090001522 DEAD/H associated; Region: DEAD_assoc; pfam08494 243090001523 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 243090001524 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 243090001525 active site 243090001526 HIGH motif; other site 243090001527 KMSKS motif; other site 243090001528 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 243090001529 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 243090001530 active site 243090001531 Zn binding site [ion binding]; other site 243090001532 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 243090001533 histidinol dehydrogenase; Region: hisD; TIGR00069 243090001534 NAD binding site [chemical binding]; other site 243090001535 dimerization interface [polypeptide binding]; other site 243090001536 product binding site; other site 243090001537 substrate binding site [chemical binding]; other site 243090001538 zinc binding site [ion binding]; other site 243090001539 catalytic residues [active] 243090001540 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 243090001541 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243090001542 dimer interface [polypeptide binding]; other site 243090001543 active site 243090001544 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 243090001545 cosmid pircos-b1f04/ cosmid pircos-c4h01 joining point 243090001546 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 243090001547 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090001548 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 243090001549 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090001550 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 243090001551 O-methyltransferase; Region: Methyltransf_2; pfam00891 243090001552 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 243090001553 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 243090001554 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 243090001555 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 243090001556 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 243090001557 DNA binding site [nucleotide binding] 243090001558 active site 243090001559 Beta-lactamase; Region: Beta-lactamase; pfam00144 243090001560 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090001561 Sulfatase; Region: Sulfatase; pfam00884 243090001562 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 243090001563 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 243090001564 active site 243090001565 Protein of unknown function (DUF502); Region: DUF502; cl01107 243090001566 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 243090001567 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 243090001568 nucleotide binding site [chemical binding]; other site 243090001569 GTP-binding protein LepA; Provisional; Region: PRK05433 243090001570 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 243090001571 G1 box; other site 243090001572 putative GEF interaction site [polypeptide binding]; other site 243090001573 GTP/Mg2+ binding site [chemical binding]; other site 243090001574 Switch I region; other site 243090001575 G2 box; other site 243090001576 G3 box; other site 243090001577 Switch II region; other site 243090001578 G4 box; other site 243090001579 G5 box; other site 243090001580 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 243090001581 Elongation Factor G, domain II; Region: EFG_II; pfam14492 243090001582 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 243090001583 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 243090001584 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 243090001585 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243090001586 Putative Catalytic site; other site 243090001587 DXD motif; other site 243090001588 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243090001589 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 243090001590 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 243090001591 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 243090001592 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 243090001593 helicase; Provisional; Region: PTZ00110 243090001594 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 243090001595 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 243090001596 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243090001597 FAD dependent oxidoreductase; Region: DAO; pfam01266 243090001598 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243090001599 PAS fold; Region: PAS; pfam00989 243090001600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090001601 putative active site [active] 243090001602 heme pocket [chemical binding]; other site 243090001603 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243090001604 metal binding site [ion binding]; metal-binding site 243090001605 active site 243090001606 I-site; other site 243090001607 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243090001608 Zn2+ binding site [ion binding]; other site 243090001609 Mg2+ binding site [ion binding]; other site 243090001610 cosmid pircos-c4h01/ cosmid pircos-c1h03 joining point 243090001611 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 243090001612 Right handed beta helix region; Region: Beta_helix; pfam13229 243090001613 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 243090001614 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 243090001615 calcium mediated ligand binding site; other site 243090001616 intermolecular salt bridges; other site 243090001617 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 243090001618 ligand binding surface [chemical binding]; other site 243090001619 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090001620 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 243090001621 calcium mediated ligand binding site; other site 243090001622 intermolecular salt bridges; other site 243090001623 Protein of unknown function (DUF642); Region: DUF642; cl19911 243090001624 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 243090001625 ligand binding surface [chemical binding]; other site 243090001626 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090001627 Ca2+ binding site [ion binding]; other site 243090001628 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090001629 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090001630 Ca2+ binding site [ion binding]; other site 243090001631 Right handed beta helix region; Region: Beta_helix; pfam13229 243090001632 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090001633 VCBS repeat; Region: VCBS_repeat; TIGR01965 243090001634 Protein of unknown function (DUF642); Region: DUF642; cl19911 243090001635 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 243090001636 VCBS repeat; Region: VCBS_repeat; TIGR01965 243090001637 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090001638 Ca2+ binding site [ion binding]; other site 243090001639 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090001640 Ca2+ binding site [ion binding]; other site 243090001641 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090001642 Ca2+ binding site [ion binding]; other site 243090001643 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090001644 Ca2+ binding site [ion binding]; other site 243090001645 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243090001646 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243090001647 Outer membrane efflux protein; Region: OEP; pfam02321 243090001648 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090001649 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090001650 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090001651 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090001652 Peptidase family M50; Region: Peptidase_M50; pfam02163 243090001653 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 243090001654 active site 243090001655 putative substrate binding region [chemical binding]; other site 243090001656 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090001657 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090001658 cosmid pircos-c1h03/ cosmid pircos-a1h12 joining point 243090001659 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 243090001660 O-Antigen ligase; Region: Wzy_C; pfam04932 243090001661 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 243090001662 dihydropteroate synthase-related protein; Region: TIGR00284 243090001663 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 243090001664 substrate binding pocket [chemical binding]; other site 243090001665 inhibitor binding site; inhibition site 243090001666 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 243090001667 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 243090001668 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 243090001669 active site 243090001670 dimer interface [polypeptide binding]; other site 243090001671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090001672 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243090001673 Walker A motif; other site 243090001674 ATP binding site [chemical binding]; other site 243090001675 Walker B motif; other site 243090001676 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 243090001677 DnaA box-binding interface [nucleotide binding]; other site 243090001678 replicative DNA helicase; Region: DnaB; TIGR00665 243090001679 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 243090001680 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 243090001681 Walker A motif; other site 243090001682 ATP binding site [chemical binding]; other site 243090001683 Walker B motif; other site 243090001684 DNA binding loops [nucleotide binding] 243090001685 Protein of unknown function (DUF1589); Region: DUF1589; pfam07628 243090001686 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 243090001687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090001688 active site 243090001689 phosphorylation site [posttranslational modification] 243090001690 intermolecular recognition site; other site 243090001691 dimerization interface [polypeptide binding]; other site 243090001692 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 243090001693 Protein of unknown function (DUF1589); Region: DUF1589; pfam07628 243090001694 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 243090001695 TRAPP trafficking subunit Trs65; Region: Trs65; pfam12735 243090001696 Domain of unknown function DUF11; Region: DUF11; pfam01345 243090001697 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 243090001698 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 243090001699 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 243090001700 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 243090001701 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243090001702 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 243090001703 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 243090001704 active site 243090001705 catalytic triad [active] 243090001706 dimer interface [polypeptide binding]; other site 243090001707 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090001708 Sulfatase; Region: Sulfatase; pfam00884 243090001709 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243090001710 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243090001711 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 243090001712 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 243090001713 FAD binding pocket [chemical binding]; other site 243090001714 FAD binding motif [chemical binding]; other site 243090001715 phosphate binding motif [ion binding]; other site 243090001716 beta-alpha-beta structure motif; other site 243090001717 NAD binding pocket [chemical binding]; other site 243090001718 Iron coordination center [ion binding]; other site 243090001719 WYL domain; Region: WYL; pfam13280 243090001720 Ferritin-like domain; Region: Ferritin; pfam00210 243090001721 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 243090001722 dinuclear metal binding motif [ion binding]; other site 243090001723 HEAT repeats; Region: HEAT_2; pfam13646 243090001724 Cytochrome c; Region: Cytochrom_C; cl11414 243090001725 Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; Region: RNase_H_like; cl14782 243090001726 GAF domain; Region: GAF; cl17456 243090001727 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 243090001728 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243090001729 Zn2+ binding site [ion binding]; other site 243090001730 Mg2+ binding site [ion binding]; other site 243090001731 Ciliary protein causing Leber congenital amaurosis disease; Region: Lebercilin; pfam15619 243090001732 cosmid pircos-a1h12/ cosmid pircos-c3h04 joining point 243090001733 transcriptional regulator PhoB; Provisional; Region: PRK10161 243090001734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090001735 active site 243090001736 intermolecular recognition site; other site 243090001737 dimerization interface [polypeptide binding]; other site 243090001738 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 243090001739 conserved repeat domain; Region: B_ant_repeat; TIGR01451 243090001740 Predicted membrane protein [Function unknown]; Region: COG1470 243090001741 Domain of unknown function DUF11; Region: DUF11; pfam01345 243090001742 Domain of unknown function DUF11; Region: DUF11; cl17728 243090001743 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 243090001744 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090001745 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090001746 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090001747 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243090001748 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243090001749 Retinal protein; Region: Retinal; pfam15449 243090001750 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 243090001751 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 243090001752 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 243090001753 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 243090001754 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243090001755 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243090001756 phosphopeptide binding site; other site 243090001757 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 243090001758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090001759 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090001760 DNA binding residues [nucleotide binding] 243090001761 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 243090001762 Predicted peptidase [General function prediction only]; Region: COG4099 243090001763 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090001764 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090001765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090001766 Walker A motif; other site 243090001767 ATP binding site [chemical binding]; other site 243090001768 Walker B motif; other site 243090001769 arginine finger; other site 243090001770 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243090001771 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090001772 metal ion-dependent adhesion site (MIDAS); other site 243090001773 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 243090001774 hypothetical protein; Provisional; Region: PRK12495 243090001775 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 243090001776 VIT family; Region: VIT1; pfam01988 243090001777 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090001778 metal ion-dependent adhesion site (MIDAS); other site 243090001779 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 243090001780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243090001781 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090001782 NAD(P) binding site [chemical binding]; other site 243090001783 active site 243090001784 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090001785 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090001786 active site 243090001787 ATP binding site [chemical binding]; other site 243090001788 substrate binding site [chemical binding]; other site 243090001789 activation loop (A-loop); other site 243090001790 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 243090001791 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 243090001792 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 243090001793 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 243090001794 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 243090001795 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 243090001796 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 243090001797 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 243090001798 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 243090001799 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243090001800 catalytic loop [active] 243090001801 iron binding site [ion binding]; other site 243090001802 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 243090001803 FAD binding pocket [chemical binding]; other site 243090001804 FAD binding motif [chemical binding]; other site 243090001805 phosphate binding motif [ion binding]; other site 243090001806 beta-alpha-beta structure motif; other site 243090001807 NAD binding pocket [chemical binding]; other site 243090001808 ApbE family; Region: ApbE; pfam02424 243090001809 Protein of unknown function (DUF539); Region: DUF539; cl01129 243090001810 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 243090001811 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 243090001812 Trehalose utilisation; Region: ThuA; pfam06283 243090001813 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090001814 cosmid pircos-c3h04/ cosmid pircos-b1f02 joining point 243090001815 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 243090001816 dimer interface [polypeptide binding]; other site 243090001817 allosteric magnesium binding site [ion binding]; other site 243090001818 active site 243090001819 aspartate-rich active site metal binding site; other site 243090001820 Schiff base residues; other site 243090001821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090001822 S-adenosylmethionine binding site [chemical binding]; other site 243090001823 Predicted transcriptional regulators [Transcription]; Region: COG1725 243090001824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243090001825 DNA-binding site [nucleotide binding]; DNA binding site 243090001826 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243090001827 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243090001828 Walker A/P-loop; other site 243090001829 ATP binding site [chemical binding]; other site 243090001830 Q-loop/lid; other site 243090001831 ABC transporter signature motif; other site 243090001832 Walker B; other site 243090001833 D-loop; other site 243090001834 H-loop/switch region; other site 243090001835 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 243090001836 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 243090001837 catalytic center binding site [active] 243090001838 ATP binding site [chemical binding]; other site 243090001839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090001840 Walker A motif; other site 243090001841 ATP binding site [chemical binding]; other site 243090001842 Walker B motif; other site 243090001843 arginine finger; other site 243090001844 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 243090001845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090001846 S-adenosylmethionine binding site [chemical binding]; other site 243090001847 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 243090001848 dimer interface [polypeptide binding]; other site 243090001849 NADP binding site [chemical binding]; other site 243090001850 catalytic residues [active] 243090001851 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090001852 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090001853 active site 243090001854 ATP binding site [chemical binding]; other site 243090001855 substrate binding site [chemical binding]; other site 243090001856 activation loop (A-loop); other site 243090001857 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090001858 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090001859 structural tetrad; other site 243090001860 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090001861 structural tetrad; other site 243090001862 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090001863 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090001864 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090001865 active site 243090001866 ATP binding site [chemical binding]; other site 243090001867 substrate binding site [chemical binding]; other site 243090001868 activation loop (A-loop); other site 243090001869 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090001870 structural tetrad; other site 243090001871 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090001872 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090001873 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090001874 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090001875 active site 243090001876 ATP binding site [chemical binding]; other site 243090001877 substrate binding site [chemical binding]; other site 243090001878 activation loop (A-loop); other site 243090001879 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090001880 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090001881 structural tetrad; other site 243090001882 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090001883 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090001884 structural tetrad; other site 243090001885 DNA helicase, putative; Region: TIGR00376 243090001886 AAA domain; Region: AAA_30; pfam13604 243090001887 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090001888 ATP binding site [chemical binding]; other site 243090001889 AAA domain; Region: AAA_12; pfam13087 243090001890 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 243090001891 cosmid pircos-b1f02/ cosmid pircos-c3e05 joining point 243090001892 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 243090001893 active site 243090001894 dimer interface [polypeptide binding]; other site 243090001895 metal binding site [ion binding]; metal-binding site 243090001896 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 243090001897 transcriptional activator RfaH; Region: RfaH; TIGR01955 243090001898 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 243090001899 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 243090001900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090001901 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243090001902 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 243090001903 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 243090001904 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090001905 Cytochrome c7; Region: Cytochrome_C7; cl19206 243090001906 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 243090001907 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 243090001908 heme-binding site [chemical binding]; other site 243090001909 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090001910 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090001911 structural tetrad; other site 243090001912 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 243090001913 Calx-beta domain; Region: Calx-beta; cl02522 243090001914 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 243090001915 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 243090001916 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 243090001917 Calx-beta domain; Region: Calx-beta; cl02522 243090001918 BDLF3; Provisional; Region: PHA03255 243090001919 Calx-beta domain; Region: Calx-beta; cl02522 243090001920 Calx-beta domain; Region: Calx-beta; cl02522 243090001921 Cna protein B-type domain; Region: Cna_B; pfam05738 243090001922 Cna protein B-type domain; Region: Cna_B; pfam05738 243090001923 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090001924 Ca2+ binding site [ion binding]; other site 243090001925 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 243090001926 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 243090001927 putative active site [active] 243090001928 putative metal binding site [ion binding]; other site 243090001929 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 243090001930 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243090001931 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090001932 cosmid pircos-c3e05/ cosmid pircos-c2b05 joining point 243090001933 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090001934 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 243090001935 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243090001936 catalytic residues [active] 243090001937 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090001938 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090001939 DNA translocase FtsK; Provisional; Region: PRK10263 243090001940 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 243090001941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090001942 TPR motif; other site 243090001943 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 243090001944 Pup-ligase protein; Region: Pup_ligase; pfam03136 243090001945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090001946 binding surface 243090001947 TPR motif; other site 243090001948 TPR repeat; Region: TPR_11; pfam13414 243090001949 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090001950 TPR motif; other site 243090001951 TPR repeat; Region: TPR_11; pfam13414 243090001952 binding surface 243090001953 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 243090001954 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 243090001955 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 243090001956 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 243090001957 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 243090001958 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 243090001959 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243090001960 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090001961 HEAT repeats; Region: HEAT_2; pfam13646 243090001962 HEAT repeats; Region: HEAT_2; pfam13646 243090001963 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 243090001964 Cytochrome c; Region: Cytochrom_C; cl11414 243090001965 PEGA domain; Region: PEGA; pfam08308 243090001966 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 243090001967 dimer interface [polypeptide binding]; other site 243090001968 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 243090001969 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 243090001970 active site 243090001971 NTP binding site [chemical binding]; other site 243090001972 metal binding triad [ion binding]; metal-binding site 243090001973 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 243090001974 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 243090001975 pyruvate phosphate dikinase; Provisional; Region: PRK09279 243090001976 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 243090001977 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243090001978 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 243090001979 cosmid pircos-c2b05/ cosmid pircos-d3a10 joining point 243090001980 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090001981 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 243090001982 putative ADP-binding pocket [chemical binding]; other site 243090001983 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 243090001984 PAS fold; Region: PAS_3; pfam08447 243090001985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090001986 putative active site [active] 243090001987 heme pocket [chemical binding]; other site 243090001988 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090001989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090001990 dimer interface [polypeptide binding]; other site 243090001991 phosphorylation site [posttranslational modification] 243090001992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090001993 ATP binding site [chemical binding]; other site 243090001994 Mg2+ binding site [ion binding]; other site 243090001995 G-X-G motif; other site 243090001996 Regulator of ribonuclease activity B; Region: RraB; cl19506 243090001997 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 243090001998 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 243090001999 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 243090002000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090002001 nucleotide binding region [chemical binding]; other site 243090002002 ATP-binding site [chemical binding]; other site 243090002003 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 243090002004 putative active site [active] 243090002005 metal binding site [ion binding]; metal-binding site 243090002006 homodimer binding site [polypeptide binding]; other site 243090002007 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 243090002008 RNA binding site [nucleotide binding]; other site 243090002009 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 243090002010 RNA binding site [nucleotide binding]; other site 243090002011 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 243090002012 RNA binding site [nucleotide binding]; other site 243090002013 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 243090002014 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 243090002015 RNA binding site [nucleotide binding]; other site 243090002016 xylulokinase; Provisional; Region: PRK15027 243090002017 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 243090002018 Di-iron ligands [ion binding]; other site 243090002019 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 243090002020 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 243090002021 FHIPEP family; Region: FHIPEP; cl07980 243090002022 Uncharacterized conserved protein [Function unknown]; Region: COG3743 243090002023 Protein of unknown function, DUF481; Region: DUF481; pfam04338 243090002024 TadE-like protein; Region: TadE; pfam07811 243090002025 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 243090002026 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA_subfamily_ECM; cd01450 243090002027 integrin inhibitor binding pocket; other site 243090002028 metal ion-dependent adhesion site (MIDAS); other site 243090002029 integrin-collagen binding site; other site 243090002030 putative vWF-collagen binding site; other site 243090002031 glycoprotein Ib (GpIb) binding site [polypeptide binding]; other site 243090002032 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 243090002033 TadE-like protein; Region: TadE; pfam07811 243090002034 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 243090002035 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090002036 putative NAD(P) binding site [chemical binding]; other site 243090002037 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090002038 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090002039 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090002040 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090002041 protein binding site [polypeptide binding]; other site 243090002042 transcriptional regulator ICP4; Provisional; Region: PHA03307 243090002043 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 243090002044 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 243090002045 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 243090002046 Proline racemase; Region: Pro_racemase; pfam05544 243090002047 cosmid pircos-d3a10/ cosmid pircos-a4e12 joining point 243090002048 von Hippel-Landau (pVHL) tumor suppressor protein; Region: pVHL; cd05468 243090002049 pVHL-HIF-1alpha interaction [polypeptide binding]; other site 243090002050 pVHL-ElonginB-ElonginC (VBC) interface [polypeptide binding]; other site 243090002051 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 243090002052 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243090002053 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243090002054 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 243090002055 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 243090002056 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243090002057 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090002058 Sulfatase; Region: Sulfatase; pfam00884 243090002059 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243090002060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090002061 binding surface 243090002062 TPR motif; other site 243090002063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090002064 TPR motif; other site 243090002065 binding surface 243090002066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090002067 TPR motif; other site 243090002068 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090002069 hypothetical protein; Provisional; Region: PRK06771 243090002070 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 243090002071 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 243090002072 putative active site [active] 243090002073 putative metal binding site [ion binding]; other site 243090002074 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 243090002075 putative ligand binding site [chemical binding]; other site 243090002076 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 243090002077 active site 243090002078 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 243090002079 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 243090002080 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 243090002081 active site 243090002082 putative substrate binding pocket [chemical binding]; other site 243090002083 Beta-lactamase; Region: Beta-lactamase; pfam00144 243090002084 acyl-CoA synthetase; Validated; Region: PRK05850 243090002085 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 243090002086 acyl-activating enzyme (AAE) consensus motif; other site 243090002087 active site 243090002088 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243090002089 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 243090002090 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 243090002091 aconitate hydratase; Validated; Region: PRK09277 243090002092 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 243090002093 substrate binding site [chemical binding]; other site 243090002094 ligand binding site [chemical binding]; other site 243090002095 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 243090002096 substrate binding site [chemical binding]; other site 243090002097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243090002098 putative substrate translocation pore; other site 243090002099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090002100 S-adenosylmethionine binding site [chemical binding]; other site 243090002101 TPR repeat; Region: TPR_11; pfam13414 243090002102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090002103 binding surface 243090002104 TPR motif; other site 243090002105 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 243090002106 GcpE protein; Region: GcpE; pfam04551 243090002107 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 243090002108 QPP; Region: QPP; pfam07640 243090002109 Protein of unknown function (DUF1581); Region: DUF1581; pfam07619 243090002110 Protein of unknown function (DUF1583); Region: DUF1583; pfam07622 243090002111 cosmid pircos-a4e12/ cosmid pircos-d3b10 joining point 243090002112 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090002113 Sulfatase; Region: Sulfatase; pfam00884 243090002114 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 243090002115 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 243090002116 Leucine rich repeat; Region: LRR_8; pfam13855 243090002117 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 243090002118 QPP; Region: QPP; pfam07640 243090002119 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 243090002120 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243090002121 active site 243090002122 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 243090002123 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 243090002124 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 243090002125 TPP-binding site; other site 243090002126 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243090002127 PYR/PP interface [polypeptide binding]; other site 243090002128 dimer interface [polypeptide binding]; other site 243090002129 TPP binding site [chemical binding]; other site 243090002130 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243090002131 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 243090002132 substrate binding pocket [chemical binding]; other site 243090002133 chain length determination region; other site 243090002134 active site lid residues [active] 243090002135 substrate-Mg2+ binding site; other site 243090002136 catalytic residues [active] 243090002137 aspartate-rich region 1; other site 243090002138 aspartate-rich region 2; other site 243090002139 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 243090002140 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 243090002141 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_32; cd04691 243090002142 nudix motif; other site 243090002143 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 243090002144 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 243090002145 active site 243090002146 catalytic site [active] 243090002147 homodimer interface [polypeptide binding]; other site 243090002148 Lid 1; other site 243090002149 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 243090002150 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 243090002151 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090002152 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090002153 active site 243090002154 ATP binding site [chemical binding]; other site 243090002155 substrate binding site [chemical binding]; other site 243090002156 activation loop (A-loop); other site 243090002157 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 243090002158 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 243090002159 metal binding site [ion binding]; metal-binding site 243090002160 substrate binding pocket [chemical binding]; other site 243090002161 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090002162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090002163 active site 243090002164 phosphorylation site [posttranslational modification] 243090002165 intermolecular recognition site; other site 243090002166 dimerization interface [polypeptide binding]; other site 243090002167 Predicted membrane protein [Function unknown]; Region: COG4129 243090002168 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 243090002169 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 243090002170 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243090002171 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243090002172 DDE superfamily endonuclease; Region: DDE_5; pfam13546 243090002173 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl19859 243090002174 cosmid pircos-d3b10/ cosmid pircos-a1e06 joining point 243090002175 LssY C-terminus; Region: LssY_C; pfam14067 243090002176 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 243090002177 Conserved TM helix; Region: TM_helix; pfam05552 243090002178 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243090002179 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 243090002180 Protein of unknown function (DUF1584); Region: PEGSRP; pfam07623 243090002181 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243090002182 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243090002183 P-loop; other site 243090002184 Magnesium ion binding site [ion binding]; other site 243090002185 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 243090002186 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 243090002187 Probable Catalytic site; other site 243090002188 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; cl12074 243090002189 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090002190 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090002191 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090002192 structural tetrad; other site 243090002193 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090002194 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090002195 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090002196 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 243090002197 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 243090002198 FAD binding pocket [chemical binding]; other site 243090002199 FAD binding motif [chemical binding]; other site 243090002200 phosphate binding motif [ion binding]; other site 243090002201 beta-alpha-beta structure motif; other site 243090002202 NAD binding pocket [chemical binding]; other site 243090002203 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243090002204 catalytic loop [active] 243090002205 iron binding site [ion binding]; other site 243090002206 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 243090002207 classical (c) SDRs; Region: SDR_c; cd05233 243090002208 NAD(P) binding site [chemical binding]; other site 243090002209 active site 243090002210 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 243090002211 classical (c) SDRs; Region: SDR_c; cd05233 243090002212 NAD(P) binding site [chemical binding]; other site 243090002213 active site 243090002214 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 243090002215 catalytic residues [active] 243090002216 dimer interface [polypeptide binding]; other site 243090002217 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 243090002218 YTV; Region: YTV; pfam07639 243090002219 YTV; Region: YTV; pfam07639 243090002220 YTV; Region: YTV; pfam07639 243090002221 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 243090002222 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 243090002223 CoA binding domain; Region: CoA_binding; pfam02629 243090002224 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090002225 Sulfatase; Region: Sulfatase; pfam00884 243090002226 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 243090002227 putative ligand binding site [chemical binding]; other site 243090002228 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 243090002229 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 243090002230 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 243090002231 cosmid pircos-a1e06/ cosmid pircos-b2g09 joining point 243090002232 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 243090002233 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090002234 SelR domain; Region: SelR; cl15841 243090002235 Predicted integral membrane protein [Function unknown]; Region: COG0392 243090002236 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 243090002237 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 243090002238 hinge; other site 243090002239 active site 243090002240 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 243090002241 Eisosome component PIL1; Region: Pil1; pfam13805 243090002242 large tegument protein UL36; Provisional; Region: PHA03247 243090002243 Protein of unknown function (DUF1590); Region: DUF1590; pfam07629 243090002244 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243090002245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243090002246 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243090002247 Protein of unknown function (DUF1586); Region: DUF1586; pfam07625 243090002248 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243090002249 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243090002250 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243090002251 P-loop; other site 243090002252 Magnesium ion binding site [ion binding]; other site 243090002253 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 243090002254 ParB-like nuclease domain; Region: ParB; smart00470 243090002255 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090002256 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090002257 active site 243090002258 ATP binding site [chemical binding]; other site 243090002259 substrate binding site [chemical binding]; other site 243090002260 activation loop (A-loop); other site 243090002261 PAS domain S-box; Region: sensory_box; TIGR00229 243090002262 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090002263 putative active site [active] 243090002264 heme pocket [chemical binding]; other site 243090002265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090002266 PAS fold; Region: PAS_3; pfam08447 243090002267 putative active site [active] 243090002268 heme pocket [chemical binding]; other site 243090002269 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 243090002270 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090002271 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090002272 DNA binding residues [nucleotide binding] 243090002273 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 243090002274 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 243090002275 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 243090002276 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090002277 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 243090002278 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 243090002279 Rhomboid family; Region: Rhomboid; cl11446 243090002280 cosmid pircos-b2g09/ cosmid pircos-a1a06 joining point 243090002281 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090002282 Sulfatase; Region: Sulfatase; pfam00884 243090002283 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 243090002284 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 243090002285 NAD binding site [chemical binding]; other site 243090002286 catalytic Zn binding site [ion binding]; other site 243090002287 structural Zn binding site [ion binding]; other site 243090002288 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 243090002289 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090002290 Sulfatase; Region: Sulfatase; pfam00884 243090002291 Laminin G domain; Region: LamG; smart00282 243090002292 arylsulfatase; Provisional; Region: PRK13759 243090002293 Sulfatase; Region: Sulfatase; pfam00884 243090002294 Glycosyl hydrolase family 43; Region: GH43_7; cd08986 243090002295 active site 243090002296 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243090002297 Outer membrane efflux protein; Region: OEP; pfam02321 243090002298 Outer membrane efflux protein; Region: OEP; pfam02321 243090002299 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 243090002300 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090002301 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090002302 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090002303 SpoIIAA-like; Region: SpoIIAA-like; pfam11964 243090002304 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 243090002305 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 243090002306 active site 243090002307 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243090002308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090002309 active site 243090002310 phosphorylation site [posttranslational modification] 243090002311 intermolecular recognition site; other site 243090002312 dimerization interface [polypeptide binding]; other site 243090002313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090002314 Walker A motif; other site 243090002315 ATP binding site [chemical binding]; other site 243090002316 Walker B motif; other site 243090002317 arginine finger; other site 243090002318 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243090002319 Short C-terminal domain; Region: SHOCT; pfam09851 243090002320 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090002321 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090002322 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 243090002323 active site 243090002324 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 243090002325 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 243090002326 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 243090002327 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 243090002328 cosmid pircos-a1a06/ cosmid pircos-b2b09 joining point 243090002329 Transposase IS200 like; Region: Y1_Tnp; pfam01797 243090002330 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243090002331 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243090002332 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090002333 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 243090002334 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243090002335 HSP70 interaction site [polypeptide binding]; other site 243090002336 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 243090002337 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 243090002338 nucleotide binding site [chemical binding]; other site 243090002339 putative NEF/HSP70 interaction site [polypeptide binding]; other site 243090002340 SBD interface [polypeptide binding]; other site 243090002341 Protein of unknown function (DUF726); Region: DUF726; pfam05277 243090002342 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243090002343 RNA binding surface [nucleotide binding]; other site 243090002344 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 243090002345 putative catalytic site [active] 243090002346 putative metal binding site [ion binding]; other site 243090002347 putative phosphate binding site [ion binding]; other site 243090002348 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 243090002349 Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237 243090002350 legume lectins; Region: lectin_L-type; cd01951 243090002351 homotetramer interaction site [polypeptide binding]; other site 243090002352 carbohydrate binding site [chemical binding]; other site 243090002353 metal binding site [ion binding]; metal-binding site 243090002354 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090002355 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 243090002356 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090002357 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090002358 Ca2+ binding site [ion binding]; other site 243090002359 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090002360 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090002361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090002362 TPR motif; other site 243090002363 binding surface 243090002364 exosortase; Region: 8TM_EpsH; TIGR02602 243090002365 cosmid pircos-b2b09/ cosmid pircos-c4g06 joining point 243090002366 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 243090002367 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 243090002368 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 243090002369 AAA domain; Region: AAA_31; pfam13614 243090002370 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243090002371 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 243090002372 metal-binding site 243090002373 putative acyl transferase; Provisional; Region: PRK10502 243090002374 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 243090002375 putative trimer interface [polypeptide binding]; other site 243090002376 putative active site [active] 243090002377 putative substrate binding site [chemical binding]; other site 243090002378 putative CoA binding site [chemical binding]; other site 243090002379 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090002380 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 243090002381 putative ADP-binding pocket [chemical binding]; other site 243090002382 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090002383 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090002384 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090002385 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090002386 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 243090002387 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243090002388 Transposase [DNA replication, recombination, and repair]; Region: COG5433 243090002389 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090002390 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 243090002391 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090002392 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090002393 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090002394 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090002395 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090002396 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 243090002397 putative ADP-binding pocket [chemical binding]; other site 243090002398 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 243090002399 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 243090002400 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 243090002401 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090002402 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 243090002403 cosmid pircos-c4g06/ cosmid pircos-c3c08 joining point 243090002404 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 243090002405 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090002406 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090002407 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090002408 extended (e) SDRs; Region: SDR_e; cd08946 243090002409 NAD(P) binding site [chemical binding]; other site 243090002410 active site 243090002411 substrate binding site [chemical binding]; other site 243090002412 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 243090002413 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 243090002414 trimer interface [polypeptide binding]; other site 243090002415 active site 243090002416 substrate binding site [chemical binding]; other site 243090002417 CoA binding site [chemical binding]; other site 243090002418 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243090002419 putative efflux protein, MATE family; Region: matE; TIGR00797 243090002420 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 243090002421 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 243090002422 NAD binding site [chemical binding]; other site 243090002423 substrate binding site [chemical binding]; other site 243090002424 homodimer interface [polypeptide binding]; other site 243090002425 active site 243090002426 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 243090002427 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 243090002428 NADP-binding site; other site 243090002429 homotetramer interface [polypeptide binding]; other site 243090002430 substrate binding site [chemical binding]; other site 243090002431 homodimer interface [polypeptide binding]; other site 243090002432 active site 243090002433 QPP; Region: QPP; pfam07640 243090002434 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 243090002435 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 243090002436 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 243090002437 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 243090002438 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 243090002439 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 243090002440 NADP-binding site; other site 243090002441 homotetramer interface [polypeptide binding]; other site 243090002442 substrate binding site [chemical binding]; other site 243090002443 homodimer interface [polypeptide binding]; other site 243090002444 active site 243090002445 Protein of unknown function (DUF1586); Region: DUF1586; pfam07625 243090002446 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 243090002447 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 243090002448 NADP binding site [chemical binding]; other site 243090002449 active site 243090002450 putative substrate binding site [chemical binding]; other site 243090002451 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 243090002452 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243090002453 Zn2+ binding site [ion binding]; other site 243090002454 Mg2+ binding site [ion binding]; other site 243090002455 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 243090002456 active site 243090002457 trimer interface [polypeptide binding]; other site 243090002458 allosteric site; other site 243090002459 active site lid [active] 243090002460 hexamer (dimer of trimers) interface [polypeptide binding]; other site 243090002461 Domain of unknown function (DUF389); Region: DUF389; pfam04087 243090002462 Transcriptional regulators [Transcription]; Region: PurR; COG1609 243090002463 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 243090002464 DNA binding site [nucleotide binding] 243090002465 domain linker motif; other site 243090002466 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_9; cd06290 243090002467 putative dimerization interface [polypeptide binding]; other site 243090002468 putative ligand binding site [chemical binding]; other site 243090002469 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 243090002470 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243090002471 RNA binding site [nucleotide binding]; other site 243090002472 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 243090002473 RNA binding site [nucleotide binding]; other site 243090002474 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 243090002475 RNA binding site [nucleotide binding]; other site 243090002476 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243090002477 RNA binding site [nucleotide binding]; other site 243090002478 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243090002479 RNA binding site [nucleotide binding]; other site 243090002480 S1 RNA binding domain; Region: S1; pfam00575 243090002481 RNA binding site [nucleotide binding]; other site 243090002482 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 243090002483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090002484 HAMP domain; Region: HAMP; pfam00672 243090002485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090002486 dimer interface [polypeptide binding]; other site 243090002487 phosphorylation site [posttranslational modification] 243090002488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090002489 ATP binding site [chemical binding]; other site 243090002490 Mg2+ binding site [ion binding]; other site 243090002491 G-X-G motif; other site 243090002492 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243090002493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090002494 active site 243090002495 phosphorylation site [posttranslational modification] 243090002496 intermolecular recognition site; other site 243090002497 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 243090002498 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 243090002499 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 243090002500 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 243090002501 Planctomycete PGAMP; Region: PGAMP; pfam07644 243090002502 Transposase IS200 like; Region: Y1_Tnp; cl00848 243090002503 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 243090002504 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 243090002505 Int/Topo IB signature motif; other site 243090002506 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 243090002507 Putative transposase; Region: Y2_Tnp; pfam04986 243090002508 Protein of unknown function (DUF1556); Region: DUF1556; pfam07590 243090002509 Planctomycete PGAMP; Region: PGAMP; pfam07644 243090002510 Planctomycete PGAMP; Region: PGAMP; pfam07644 243090002511 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 243090002512 L-lactate dehydrogenase-like enzymes; Region: LDH_like; cd00300 243090002513 NAD(P) binding site [chemical binding]; other site 243090002514 dimer interface [polypeptide binding]; other site 243090002515 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243090002516 substrate binding site [chemical binding]; other site 243090002517 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 243090002518 intersubunit interface [polypeptide binding]; other site 243090002519 active site 243090002520 Zn2+ binding site [ion binding]; other site 243090002521 cosmid pircos-c3c08/ cosmid pircos-b2e02 joining point 243090002522 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 243090002523 Hexamer/Pentamer interface [polypeptide binding]; other site 243090002524 central pore; other site 243090002525 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 243090002526 Hexamer/Pentamer interface [polypeptide binding]; other site 243090002527 central pore; other site 243090002528 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 243090002529 putative catalytic cysteine [active] 243090002530 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 243090002531 Hexamer/Pentamer interface [polypeptide binding]; other site 243090002532 central pore; other site 243090002533 Acetokinase family; Region: Acetate_kinase; cl17229 243090002534 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 243090002535 Hexamer interface [polypeptide binding]; other site 243090002536 Hexagonal pore residue; other site 243090002537 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 243090002538 Hexamer interface [polypeptide binding]; other site 243090002539 Hexagonal pore residue; other site 243090002540 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 243090002541 Propanediol utilisation protein PduL; Region: PduL; pfam06130 243090002542 Propanediol utilisation protein PduL; Region: PduL; pfam06130 243090002543 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 243090002544 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 243090002545 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 243090002546 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243090002547 Atrophin-1 family; Region: Atrophin-1; pfam03154 243090002548 DNA topoisomerase 2-like protein; Provisional; Region: PTZ00108 243090002549 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 243090002550 active site 243090002551 catalytic triad [active] 243090002552 oxyanion hole [active] 243090002553 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090002554 HEAT repeats; Region: HEAT_2; pfam13646 243090002555 Auracyanins A and B and similar proteins; Region: Auracyanin; cd04233 243090002556 Type 1 (T1) Cu binding site [ion binding]; other site 243090002557 Cytochrome c; Region: Cytochrom_C; cl11414 243090002558 cosmid pircos-b2e02/ cosmid pircos-b3b03 joining point 243090002559 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090002560 Sulfatase; Region: Sulfatase; cl19157 243090002561 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 243090002562 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 243090002563 active site 243090002564 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 243090002565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090002566 active site 243090002567 phosphorylation site [posttranslational modification] 243090002568 intermolecular recognition site; other site 243090002569 dimerization interface [polypeptide binding]; other site 243090002570 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243090002571 DNA binding site [nucleotide binding] 243090002572 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 243090002573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090002574 S-adenosylmethionine binding site [chemical binding]; other site 243090002575 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 243090002576 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 243090002577 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 243090002578 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 243090002579 GTP1/OBG; Region: GTP1_OBG; pfam01018 243090002580 Obg GTPase; Region: Obg; cd01898 243090002581 G1 box; other site 243090002582 GTP/Mg2+ binding site [chemical binding]; other site 243090002583 Switch I region; other site 243090002584 G2 box; other site 243090002585 G3 box; other site 243090002586 Switch II region; other site 243090002587 G4 box; other site 243090002588 G5 box; other site 243090002589 Type III pantothenate kinase; Region: Pan_kinase; pfam03309 243090002590 AMOP domain; Region: AMOP; cl02758 243090002591 Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; Region: RNase_H_like; cl14782 243090002592 glycogen branching enzyme; Provisional; Region: PRK05402 243090002593 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 243090002594 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 243090002595 active site 243090002596 catalytic site [active] 243090002597 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 243090002598 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090002599 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090002600 7-cyano-7-deazaguanine reductase; Region: QueF-II; TIGR03139 243090002601 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 243090002602 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090002603 FeS/SAM binding site; other site 243090002604 Methylamine utilization protein MauL; Region: MauL; cd04221 243090002605 putative Type 1 (T1) Cu binding site [ion binding]; other site 243090002606 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 243090002607 Peptidase family M50; Region: Peptidase_M50; pfam02163 243090002608 active site 243090002609 putative substrate binding region [chemical binding]; other site 243090002610 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090002611 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 243090002612 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090002613 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090002614 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 243090002615 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 243090002616 xylose isomerase; Provisional; Region: PRK05474 243090002617 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 243090002618 FAD binding domain; Region: FAD_binding_4; cl19922 243090002619 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 243090002620 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090002621 Sulfatase; Region: Sulfatase; cl19157 243090002622 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243090002623 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243090002624 cosmid pircos-b3b03/ cosmid pircos-b1g12 joining point 243090002625 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243090002626 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243090002627 phosphopeptide binding site; other site 243090002628 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090002629 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090002630 active site 243090002631 ATP binding site [chemical binding]; other site 243090002632 substrate binding site [chemical binding]; other site 243090002633 activation loop (A-loop); other site 243090002634 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090002635 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 243090002636 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 243090002637 dimerization interface 3.5A [polypeptide binding]; other site 243090002638 active site 243090002639 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cd10546 243090002640 putative active site [active] 243090002641 redox center [active] 243090002642 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243090002643 PAS fold; Region: PAS_4; pfam08448 243090002644 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243090002645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090002646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090002647 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090002648 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090002649 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090002650 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090002651 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090002652 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090002653 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090002654 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090002655 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090002656 Sulfatase; Region: Sulfatase; pfam00884 243090002657 Kappa-carrageenase, member of glycosyl hydrolase family 16; Region: GH16_kappa_carrageenase; cd02177 243090002658 active site 243090002659 catalytic residues [active] 243090002660 arylsulfatase; Provisional; Region: PRK13759 243090002661 Sulfatase; Region: Sulfatase; cl19157 243090002662 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 243090002663 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 243090002664 Rhomboid family; Region: Rhomboid; pfam01694 243090002665 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 243090002666 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090002667 Cytochrome c; Region: Cytochrom_C; cl11414 243090002668 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 243090002669 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cl00053 243090002670 active site 243090002671 catalytic residues [active] 243090002672 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 243090002673 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090002674 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 243090002675 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243090002676 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 243090002677 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 243090002678 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 243090002679 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 243090002680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090002681 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243090002682 dimerization interface [polypeptide binding]; other site 243090002683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090002684 dimer interface [polypeptide binding]; other site 243090002685 phosphorylation site [posttranslational modification] 243090002686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090002687 ATP binding site [chemical binding]; other site 243090002688 Mg2+ binding site [ion binding]; other site 243090002689 G-X-G motif; other site 243090002690 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243090002691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090002692 active site 243090002693 phosphorylation site [posttranslational modification] 243090002694 intermolecular recognition site; other site 243090002695 dimerization interface [polypeptide binding]; other site 243090002696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090002697 Walker A motif; other site 243090002698 ATP binding site [chemical binding]; other site 243090002699 Walker B motif; other site 243090002700 arginine finger; other site 243090002701 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243090002702 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090002703 Sulfatase; Region: Sulfatase; pfam00884 243090002704 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 243090002705 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 243090002706 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 243090002707 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 243090002708 cosmid pircos-b1g12/ cosmid pircos-b1b07 joining point 243090002709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243090002710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090002711 active site 243090002712 phosphorylation site [posttranslational modification] 243090002713 intermolecular recognition site; other site 243090002714 dimerization interface [polypeptide binding]; other site 243090002715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243090002716 DNA binding residues [nucleotide binding] 243090002717 dimerization interface [polypeptide binding]; other site 243090002718 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 243090002719 dimer interface [polypeptide binding]; other site 243090002720 active site 243090002721 catalytic residue [active] 243090002722 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 243090002723 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 243090002724 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 243090002725 putative active site [active] 243090002726 Flavoprotein; Region: Flavoprotein; cl19190 243090002727 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 243090002728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243090002729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090002730 S-adenosylmethionine binding site [chemical binding]; other site 243090002731 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 243090002732 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 243090002733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243090002734 motif II; other site 243090002735 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243090002736 ligand binding site [chemical binding]; other site 243090002737 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090002738 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090002739 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090002740 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090002741 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090002742 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090002743 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 243090002744 catalytic motif [active] 243090002745 Catalytic residue [active] 243090002746 Domain of unknown function (DUF329); Region: DUF329; pfam03884 243090002747 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 243090002748 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 243090002749 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243090002750 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090002751 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090002752 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090002753 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 243090002754 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 243090002755 active site 243090002756 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 243090002757 active site 243090002758 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 243090002759 cosmid pircos-b1b07/ cosmid pircos-d1h02 joining point 243090002760 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 243090002761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243090002762 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 243090002763 putative catalytic site [active] 243090002764 putative metal binding site [ion binding]; other site 243090002765 putative phosphate binding site [ion binding]; other site 243090002766 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090002767 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243090002768 active site 243090002769 catalytic tetrad [active] 243090002770 HEAT repeats; Region: HEAT_2; pfam13646 243090002771 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 243090002772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090002773 binding surface 243090002774 TPR motif; other site 243090002775 TPR repeat; Region: TPR_11; pfam13414 243090002776 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 243090002777 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 243090002778 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 243090002779 Protein of unknown function (DUF1598); Region: DUF1598; pfam07643 243090002780 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 243090002781 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 243090002782 putative active site [active] 243090002783 catalytic site [active] 243090002784 putative metal binding site [ion binding]; other site 243090002785 Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356 243090002786 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 243090002787 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090002788 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090002789 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 243090002790 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090002791 Trp docking motif [polypeptide binding]; other site 243090002792 active site 243090002793 PQQ-like domain; Region: PQQ_2; pfam13360 243090002794 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 243090002795 S1 domain; Region: S1_2; pfam13509 243090002796 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 243090002797 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090002798 FecR protein; Region: FecR; pfam04773 243090002799 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090002800 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090002801 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090002802 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 243090002803 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090002804 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090002805 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243090002806 catalytic residues [active] 243090002807 PEP-CTERM motif; Region: VPEP; pfam07589 243090002808 cosmid pircos-d1h02/ cosmid pircos-c4g03 joining point 243090002809 CAAX protease self-immunity; Region: Abi; pfam02517 243090002810 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090002811 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090002812 active site 243090002813 ATP binding site [chemical binding]; other site 243090002814 substrate binding site [chemical binding]; other site 243090002815 activation loop (A-loop); other site 243090002816 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 243090002817 Cell division protein FtsA; Region: FtsA; cl17206 243090002818 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 243090002819 DNA polymerase III, delta subunit; Region: holA; TIGR01128 243090002820 PAS fold; Region: PAS_3; pfam08447 243090002821 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090002822 heme pocket [chemical binding]; other site 243090002823 putative active site [active] 243090002824 PAS fold; Region: PAS; pfam00989 243090002825 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090002826 putative active site [active] 243090002827 heme pocket [chemical binding]; other site 243090002828 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243090002829 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090002830 putative active site [active] 243090002831 heme pocket [chemical binding]; other site 243090002832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090002833 dimer interface [polypeptide binding]; other site 243090002834 phosphorylation site [posttranslational modification] 243090002835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090002836 ATP binding site [chemical binding]; other site 243090002837 Mg2+ binding site [ion binding]; other site 243090002838 G-X-G motif; other site 243090002839 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 243090002840 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 243090002841 QPP; Region: QPP; pfam07640 243090002842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243090002843 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090002844 NAD(P) binding site [chemical binding]; other site 243090002845 active site 243090002846 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 243090002847 putative active site [active] 243090002848 redox center [active] 243090002849 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243090002850 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243090002851 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243090002852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090002853 S-adenosylmethionine binding site [chemical binding]; other site 243090002854 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090002855 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090002856 PSP1 C-terminal conserved region; Region: PSP1; cl00770 243090002857 Verruc_Plancto-restricted protein; Region: Plancto_Ver_chp; TIGR04138 243090002858 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243090002859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090002860 S-adenosylmethionine binding site [chemical binding]; other site 243090002861 cosmid pircos-c4g03/ cosmid pircos-d1d06 joining point 243090002862 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 243090002863 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 243090002864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090002865 Coenzyme A binding pocket [chemical binding]; other site 243090002866 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 243090002867 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 243090002868 Phosphopantetheine attachment site; Region: PP-binding; cl09936 243090002869 Phosphopantetheine attachment site; Region: PP-binding; cl09936 243090002870 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243090002871 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 243090002872 cosmid pircos-d1d06/ cosmid pircos-b2c03 joining point 243090002873 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090002874 PQQ-like domain; Region: PQQ_2; pfam13360 243090002875 Trp docking motif [polypeptide binding]; other site 243090002876 active site 243090002877 FtsH Extracellular; Region: FtsH_ext; pfam06480 243090002878 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 243090002879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090002880 Walker A motif; other site 243090002881 ATP binding site [chemical binding]; other site 243090002882 Walker B motif; other site 243090002883 arginine finger; other site 243090002884 Peptidase family M41; Region: Peptidase_M41; pfam01434 243090002885 GTPase RsgA; Reviewed; Region: PRK00098 243090002886 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243090002887 RNA binding site [nucleotide binding]; other site 243090002888 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 243090002889 GTPase/Zn-binding domain interface [polypeptide binding]; other site 243090002890 GTP/Mg2+ binding site [chemical binding]; other site 243090002891 G4 box; other site 243090002892 G5 box; other site 243090002893 G1 box; other site 243090002894 Switch I region; other site 243090002895 G2 box; other site 243090002896 G3 box; other site 243090002897 Switch II region; other site 243090002898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090002899 S-adenosylmethionine binding site [chemical binding]; other site 243090002900 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090002901 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090002902 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 243090002903 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243090002904 metal binding triad; other site 243090002905 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 243090002906 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 243090002907 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 243090002908 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243090002909 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 243090002910 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 243090002911 active site 243090002912 Ap4A binding cleft/pocket [chemical binding]; other site 243090002913 P4 phosphate binding site; other site 243090002914 nudix motif; other site 243090002915 putative P2/P3 phosphate binding site [ion binding]; other site 243090002916 Cytochrome C' Region: Cytochrom_C_2; cl01610 243090002917 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 243090002918 Cl- selectivity filter; other site 243090002919 Cl- binding residues [ion binding]; other site 243090002920 pore gating glutamate residue; other site 243090002921 dimer interface [polypeptide binding]; other site 243090002922 FOG: CBS domain [General function prediction only]; Region: COG0517 243090002923 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 243090002924 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243090002925 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243090002926 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243090002927 dimerization interface [polypeptide binding]; other site 243090002928 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 243090002929 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090002930 putative ADP-binding pocket [chemical binding]; other site 243090002931 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 243090002932 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 243090002933 active site 243090002934 catalytic site [active] 243090002935 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 243090002936 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 243090002937 active site 243090002938 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090002939 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 243090002940 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 243090002941 active site 243090002942 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 243090002943 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 243090002944 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243090002945 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 243090002946 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090002947 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090002948 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090002949 PQQ-like domain; Region: PQQ_2; pfam13360 243090002950 Trp docking motif [polypeptide binding]; other site 243090002951 active site 243090002952 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 243090002953 BNR repeat-like domain; Region: BNR_2; pfam13088 243090002954 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 243090002955 catalytic site [active] 243090002956 Asp-box motif; other site 243090002957 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 243090002958 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090002959 cosmid pircos-b2c03/ cosmid pircos-c2h11 joining point 243090002960 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 243090002961 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 243090002962 dimer interface [polypeptide binding]; other site 243090002963 active site 243090002964 heme binding site [chemical binding]; other site 243090002965 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 243090002966 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 243090002967 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 243090002968 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 243090002969 protein binding site [polypeptide binding]; other site 243090002970 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243090002971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243090002972 putative substrate translocation pore; other site 243090002973 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090002974 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090002975 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090002976 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090002977 Protein of unknown function (DUF1584); Region: PEGSRP; pfam07623 243090002978 cosmid pircos-c2h11/ cosmid pircos-a3c12 joining point 243090002979 Protein of unknown function (DUF1560); Region: DUF1560; pfam07597 243090002980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090002981 S-adenosylmethionine binding site [chemical binding]; other site 243090002982 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090002983 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090002984 Protein of unknown function (DUF1584); Region: PEGSRP; pfam07623 243090002985 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090002986 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090002987 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 243090002988 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 243090002989 MutS2 family protein; Region: mutS2; TIGR01069 243090002990 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 243090002991 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 243090002992 active site 243090002993 PHP Thumb interface [polypeptide binding]; other site 243090002994 metal binding site [ion binding]; metal-binding site 243090002995 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 243090002996 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 243090002997 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 243090002998 generic binding surface II; other site 243090002999 generic binding surface I; other site 243090003000 cosmid pircos-a3c12/ cosmid pircos-c2a06 joining point 243090003001 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 243090003002 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 243090003003 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 243090003004 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 243090003005 calcium binding site [ion binding]; other site 243090003006 active site 243090003007 catalytic residues [active] 243090003008 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 243090003009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 243090003010 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 243090003011 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 243090003012 Int/Topo IB signature motif; other site 243090003013 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 243090003014 Putative transposase; Region: Y2_Tnp; pfam04986 243090003015 Protein of unknown function (DUF1556); Region: DUF1556; pfam07590 243090003016 Protein of unknown function (DUF1584); Region: PEGSRP; pfam07623 243090003017 Protein of unknown function (DUF1584); Region: PEGSRP; pfam07623 243090003018 Protein of unknown function (DUF1584); Region: PEGSRP; pfam07623 243090003019 Protein of unknown function (DUF1584); Region: PEGSRP; pfam07623 243090003020 integron integrase; Region: integrase_gron; TIGR02249 243090003021 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 243090003022 Int/Topo IB signature motif; other site 243090003023 Protein of unknown function (DUF1590); Region: DUF1590; pfam07629 243090003024 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090003025 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090003026 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090003027 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 243090003028 Domain of unknown function DUF11; Region: DUF11; cl17728 243090003029 Tetratricopeptide repeat; Region: TPR_19; pfam14559 243090003030 Microtubule associated protein (MAP65/ASE1 family); Region: MAP65_ASE1; pfam03999 243090003031 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 243090003032 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243090003033 RNA binding surface [nucleotide binding]; other site 243090003034 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 243090003035 active site 243090003036 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 243090003037 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 243090003038 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243090003039 catalytic residue [active] 243090003040 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090003041 Sulfatase; Region: Sulfatase; cl19157 243090003042 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 243090003043 MMPL family; Region: MMPL; cl14618 243090003044 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 243090003045 MMPL family; Region: MMPL; cl14618 243090003046 MMPL family; Region: MMPL; cl14618 243090003047 cosmid pircos-c2a06/ cosmid pircos-c3h03 joining point 243090003048 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 243090003049 putative active site [active] 243090003050 catalytic residue [active] 243090003051 C-terminal peptidase (prc); Region: prc; TIGR00225 243090003052 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 243090003053 protein binding site [polypeptide binding]; other site 243090003054 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 243090003055 Catalytic dyad [active] 243090003056 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 243090003057 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 243090003058 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 243090003059 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 243090003060 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u1; cd03408 243090003061 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 243090003062 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090003063 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090003064 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 243090003065 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090003066 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090003067 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090003068 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090003069 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090003070 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243090003071 Strictosidine synthase; Region: Str_synth; cl19733 243090003072 anion transporter; Region: dass; TIGR00785 243090003073 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 243090003074 transmembrane helices; other site 243090003075 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 243090003076 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090003077 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090003078 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 243090003079 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 243090003080 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243090003081 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 243090003082 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 243090003083 active site 243090003084 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090003085 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 243090003086 response regulator PleD; Reviewed; Region: pleD; PRK09581 243090003087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090003088 active site 243090003089 phosphorylation site [posttranslational modification] 243090003090 intermolecular recognition site; other site 243090003091 dimerization interface [polypeptide binding]; other site 243090003092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090003093 putative active site [active] 243090003094 heme pocket [chemical binding]; other site 243090003095 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243090003096 metal binding site [ion binding]; metal-binding site 243090003097 active site 243090003098 I-site; other site 243090003099 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243090003100 Acyltransferase family; Region: Acyl_transf_3; cl19154 243090003101 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 243090003102 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243090003103 Walker A/P-loop; other site 243090003104 ATP binding site [chemical binding]; other site 243090003105 Q-loop/lid; other site 243090003106 ABC transporter signature motif; other site 243090003107 Walker B; other site 243090003108 D-loop; other site 243090003109 H-loop/switch region; other site 243090003110 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 243090003111 heterotetramer interface [polypeptide binding]; other site 243090003112 active site pocket [active] 243090003113 cleavage site 243090003114 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 243090003115 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 243090003116 YcfA-like protein; Region: YcfA; cl00752 243090003117 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 243090003118 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 243090003119 active site 243090003120 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090003121 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090003122 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 243090003123 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243090003124 RNA binding surface [nucleotide binding]; other site 243090003125 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243090003126 active site 243090003127 cosmid pircos-c3h03/ cosmid pircos-a4h02 joining point 243090003128 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090003129 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090003130 active site 243090003131 ATP binding site [chemical binding]; other site 243090003132 substrate binding site [chemical binding]; other site 243090003133 activation loop (A-loop); other site 243090003134 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 243090003135 active site 243090003136 putative metal-binding site [ion binding]; other site 243090003137 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243090003138 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 243090003139 dimer interface [polypeptide binding]; other site 243090003140 DNA binding site [nucleotide binding] 243090003141 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 243090003142 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 243090003143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243090003144 Walker A/P-loop; other site 243090003145 ATP binding site [chemical binding]; other site 243090003146 Q-loop/lid; other site 243090003147 ABC transporter signature motif; other site 243090003148 Walker B; other site 243090003149 D-loop; other site 243090003150 H-loop/switch region; other site 243090003151 Permease; Region: Permease; pfam02405 243090003152 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 243090003153 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243090003154 inhibitor-cofactor binding pocket; inhibition site 243090003155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090003156 catalytic residue [active] 243090003157 Putative phosphatase (DUF442); Region: DUF442; cl17385 243090003158 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090003159 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090003160 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090003161 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090003162 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 243090003163 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090003164 FeS/SAM binding site; other site 243090003165 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 243090003166 Peptidase family M48; Region: Peptidase_M48; cl12018 243090003167 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090003168 Sulfatase; Region: Sulfatase; pfam00884 243090003169 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 243090003170 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 243090003171 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 243090003172 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 243090003173 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 243090003174 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 243090003175 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 243090003176 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 243090003177 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 243090003178 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 243090003179 RNA binding site [nucleotide binding]; other site 243090003180 Peptidase family M41; Region: Peptidase_M41; pfam01434 243090003181 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090003182 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090003183 Uncharacterized conserved protein [Function unknown]; Region: COG5361 243090003184 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 243090003185 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 243090003186 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 243090003187 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090003188 HEAT repeats; Region: HEAT_2; pfam13646 243090003189 Cytochrome c; Region: Cytochrom_C; cl11414 243090003190 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090003191 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090003192 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090003193 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090003194 cosmid pircos-a4h02/ cosmid pircos-c2g04 joining point 243090003195 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 243090003196 active site 243090003197 trimer interface [polypeptide binding]; other site 243090003198 allosteric site; other site 243090003199 active site lid [active] 243090003200 hexamer (dimer of trimers) interface [polypeptide binding]; other site 243090003201 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 243090003202 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243090003203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090003204 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 243090003205 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 243090003206 dimerization interface [polypeptide binding]; other site 243090003207 putative active cleft [active] 243090003208 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 243090003209 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 243090003210 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 243090003211 Na binding site [ion binding]; other site 243090003212 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 243090003213 inhibitor site; inhibition site 243090003214 active site 243090003215 dimer interface [polypeptide binding]; other site 243090003216 catalytic residue [active] 243090003217 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 243090003218 catalytic site [active] 243090003219 BNR repeat-like domain; Region: BNR_2; pfam13088 243090003220 Asp-box motif; other site 243090003221 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243090003222 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 243090003223 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 243090003224 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 243090003225 PAS domain; Region: PAS_9; pfam13426 243090003226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090003227 putative active site [active] 243090003228 heme pocket [chemical binding]; other site 243090003229 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243090003230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090003231 putative active site [active] 243090003232 heme pocket [chemical binding]; other site 243090003233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243090003234 DNA binding residues [nucleotide binding] 243090003235 dimerization interface [polypeptide binding]; other site 243090003236 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 243090003237 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243090003238 CoenzymeA binding site [chemical binding]; other site 243090003239 subunit interaction site [polypeptide binding]; other site 243090003240 PHB binding site; other site 243090003241 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 243090003242 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090003243 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090003244 active site 243090003245 ATP binding site [chemical binding]; other site 243090003246 substrate binding site [chemical binding]; other site 243090003247 activation loop (A-loop); other site 243090003248 AAA ATPase domain; Region: AAA_16; pfam13191 243090003249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090003250 binding surface 243090003251 TPR motif; other site 243090003252 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090003253 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090003254 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 243090003255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090003256 dimer interface [polypeptide binding]; other site 243090003257 phosphorylation site [posttranslational modification] 243090003258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090003259 ATP binding site [chemical binding]; other site 243090003260 Mg2+ binding site [ion binding]; other site 243090003261 G-X-G motif; other site 243090003262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090003263 active site 243090003264 phosphorylation site [posttranslational modification] 243090003265 intermolecular recognition site; other site 243090003266 dimerization interface [polypeptide binding]; other site 243090003267 Hpt domain; Region: Hpt; pfam01627 243090003268 putative binding surface; other site 243090003269 active site 243090003270 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090003271 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090003272 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243090003273 Tetratricopeptide repeat; Region: TPR_6; pfam13174 243090003274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090003275 TPR motif; other site 243090003276 binding surface 243090003277 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003278 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003279 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003280 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 243090003281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090003282 binding surface 243090003283 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243090003284 TPR motif; other site 243090003285 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003286 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003287 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 243090003288 Bacterial transcriptional activator domain; Region: BTAD; smart01043 243090003289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090003290 TPR motif; other site 243090003291 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 243090003292 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003293 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003294 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003295 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003296 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 243090003297 cosmid pircos-c2g04/ cosmid pircos-b2c12 joining point 243090003298 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090003299 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090003300 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090003301 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090003302 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090003303 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090003304 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090003305 Sulfatase; Region: Sulfatase; pfam00884 243090003306 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090003307 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 243090003308 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 243090003309 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 243090003310 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 243090003311 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 243090003312 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 243090003313 Ca2+ binding site [ion binding]; other site 243090003314 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 243090003315 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243090003316 substrate binding pocket [chemical binding]; other site 243090003317 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090003318 Pectic acid lyase; Region: Pec_lyase; pfam09492 243090003319 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 243090003320 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 243090003321 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243090003322 E3 interaction surface; other site 243090003323 lipoyl attachment site [posttranslational modification]; other site 243090003324 e3 binding domain; Region: E3_binding; pfam02817 243090003325 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243090003326 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 243090003327 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 243090003328 dimer interface [polypeptide binding]; other site 243090003329 TPP-binding site [chemical binding]; other site 243090003330 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 243090003331 trimer interface [polypeptide binding]; other site 243090003332 active site 243090003333 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 243090003334 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 243090003335 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 243090003336 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 243090003337 active site 243090003338 DNA binding site [nucleotide binding] 243090003339 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 243090003340 Protein of unknown function (DUF1570); Region: DUF1570; pfam07607 243090003341 cosmid pircos-b2c12/ cosmid gap joining point 243090003342 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090003343 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090003344 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 243090003345 cosmid gap/ cosmid pircos-a1c04 joining point 243090003346 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 243090003347 active site 243090003348 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 243090003349 homotrimer interaction site [polypeptide binding]; other site 243090003350 zinc binding site [ion binding]; other site 243090003351 CDP-binding sites; other site 243090003352 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 243090003353 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 243090003354 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 243090003355 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 243090003356 CAP-like domain; other site 243090003357 active site 243090003358 primary dimer interface [polypeptide binding]; other site 243090003359 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 243090003360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090003361 ATP binding site [chemical binding]; other site 243090003362 Mg2+ binding site [ion binding]; other site 243090003363 G-X-G motif; other site 243090003364 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 243090003365 anchoring element; other site 243090003366 dimer interface [polypeptide binding]; other site 243090003367 ATP binding site [chemical binding]; other site 243090003368 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 243090003369 active site 243090003370 metal binding site [ion binding]; metal-binding site 243090003371 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 243090003372 Protein of unknown function (DUF1590); Region: DUF1590; pfam07629 243090003373 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243090003374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243090003375 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243090003376 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 243090003377 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 243090003378 ADP binding site [chemical binding]; other site 243090003379 magnesium binding site [ion binding]; other site 243090003380 putative shikimate binding site; other site 243090003381 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 243090003382 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 243090003383 active site 243090003384 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090003385 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090003386 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090003387 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243090003388 type II secretion system protein E; Region: type_II_gspE; TIGR02533 243090003389 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 243090003390 Walker A motif; other site 243090003391 ATP binding site [chemical binding]; other site 243090003392 Walker B motif; other site 243090003393 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 243090003394 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243090003395 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243090003396 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090003397 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243090003398 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090003399 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243090003400 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243090003401 NAD(P) binding site [chemical binding]; other site 243090003402 D-ribose pyranase; Provisional; Region: PRK11797 243090003403 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 243090003404 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 243090003405 ligand binding site [chemical binding]; other site 243090003406 dimerization interface [polypeptide binding]; other site 243090003407 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 243090003408 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 243090003409 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 243090003410 Walker A/P-loop; other site 243090003411 ATP binding site [chemical binding]; other site 243090003412 Q-loop/lid; other site 243090003413 ABC transporter signature motif; other site 243090003414 Walker B; other site 243090003415 D-loop; other site 243090003416 H-loop/switch region; other site 243090003417 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 243090003418 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 243090003419 TM-ABC transporter signature motif; other site 243090003420 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 243090003421 substrate binding site [chemical binding]; other site 243090003422 dimer interface [polypeptide binding]; other site 243090003423 ATP binding site [chemical binding]; other site 243090003424 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 243090003425 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 243090003426 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 243090003427 Protein of unknown function (DUF1586); Region: DUF1586; pfam07625 243090003428 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090003429 extended (e) SDRs; Region: SDR_e; cd08946 243090003430 NAD(P) binding site [chemical binding]; other site 243090003431 active site 243090003432 substrate binding site [chemical binding]; other site 243090003433 Trehalose utilisation; Region: ThuA; pfam06283 243090003434 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 243090003435 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 243090003436 cosmid pircos-a1c04/ cosmid pircos-c3c11 joining point 243090003437 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243090003438 putative DNA binding site [nucleotide binding]; other site 243090003439 putative Zn2+ binding site [ion binding]; other site 243090003440 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 243090003441 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 243090003442 Surface antigen; Region: Bac_surface_Ag; pfam01103 243090003443 haemagglutination activity domain; Region: Haemagg_act; smart00912 243090003444 Protein of unknown function (DUF342); Region: DUF342; cl19219 243090003445 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 243090003446 ligand binding surface [chemical binding]; other site 243090003447 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 243090003448 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 243090003449 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243090003450 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 243090003451 active site 243090003452 metal binding site [ion binding]; metal-binding site 243090003453 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003454 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003455 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003456 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 243090003457 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090003458 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090003459 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090003460 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 243090003461 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243090003462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090003463 cosmid pircos-c3c11/ cosmid pircos-c4e06 joining point 243090003464 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243090003465 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090003466 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 243090003467 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243090003468 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 243090003469 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 243090003470 active site 243090003471 trimer interface [polypeptide binding]; other site 243090003472 allosteric site; other site 243090003473 active site lid [active] 243090003474 hexamer (dimer of trimers) interface [polypeptide binding]; other site 243090003475 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 243090003476 GxxExxY protein; Region: GxxExxY; TIGR04256 243090003477 Protein of unknown function (DUF1581); Region: DUF1581; pfam07619 243090003478 Protein of unknown function (DUF1583); Region: DUF1583; pfam07622 243090003479 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 243090003480 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090003481 Mitochondrial import protein Pam17; Region: Pam17; pfam08566 243090003482 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090003483 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243090003484 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 243090003485 TrkA-N domain; Region: TrkA_N; pfam02254 243090003486 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 243090003487 Chain length determinant protein; Region: Wzz; pfam02706 243090003488 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 243090003489 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090003490 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090003491 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 243090003492 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 243090003493 putative active site [active] 243090003494 putative metal binding site [ion binding]; other site 243090003495 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 243090003496 trimerization site [polypeptide binding]; other site 243090003497 active site 243090003498 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 243090003499 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243090003500 catalytic residue [active] 243090003501 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 243090003502 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 243090003503 generic binding surface II; other site 243090003504 generic binding surface I; other site 243090003505 Kelch motif; Region: Kelch_1; pfam01344 243090003506 Kelch motif; Region: Kelch_1; pfam01344 243090003507 Kelch motif; Region: Kelch_6; pfam13964 243090003508 Kelch motif; Region: Kelch_6; pfam13964 243090003509 Alginate lyase; Region: Alginate_lyase2; pfam08787 243090003510 cosmid pircos-c4e06/ cosmid pircos-a2g07 joining point 243090003511 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 243090003512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090003513 active site 243090003514 phosphorylation site [posttranslational modification] 243090003515 intermolecular recognition site; other site 243090003516 dimerization interface [polypeptide binding]; other site 243090003517 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243090003518 metal binding site [ion binding]; metal-binding site 243090003519 active site 243090003520 I-site; other site 243090003521 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243090003522 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 243090003523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090003524 PAS domain; Region: PAS_9; pfam13426 243090003525 putative active site [active] 243090003526 heme pocket [chemical binding]; other site 243090003527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090003528 ATP binding site [chemical binding]; other site 243090003529 Mg2+ binding site [ion binding]; other site 243090003530 G-X-G motif; other site 243090003531 HPP family; Region: HPP; pfam04982 243090003532 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243090003533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090003534 active site 243090003535 phosphorylation site [posttranslational modification] 243090003536 intermolecular recognition site; other site 243090003537 dimerization interface [polypeptide binding]; other site 243090003538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090003539 Walker A motif; other site 243090003540 ATP binding site [chemical binding]; other site 243090003541 Walker B motif; other site 243090003542 arginine finger; other site 243090003543 PAS domain S-box; Region: sensory_box; TIGR00229 243090003544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090003545 putative active site [active] 243090003546 heme pocket [chemical binding]; other site 243090003547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090003548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090003549 dimer interface [polypeptide binding]; other site 243090003550 phosphorylation site [posttranslational modification] 243090003551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090003552 ATP binding site [chemical binding]; other site 243090003553 Mg2+ binding site [ion binding]; other site 243090003554 G-X-G motif; other site 243090003555 Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965 243090003556 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 243090003557 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243090003558 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243090003559 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243090003560 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 243090003561 short chain dehydrogenase; Validated; Region: PRK08264 243090003562 classical (c) SDR, subgroup 7; Region: SDR_c7; cd05354 243090003563 putative NAD(P) binding site [chemical binding]; other site 243090003564 active site 243090003565 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090003566 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090003567 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 243090003568 active site 243090003569 catalytic triad [active] 243090003570 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 243090003571 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090003572 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090003573 cosmid pircos-a2g07/ cosmid pircos-b1e03 joining point 243090003574 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 243090003575 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243090003576 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090003577 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090003578 Putative cyclase; Region: Cyclase; pfam04199 243090003579 Putative cyclase; Region: Cyclase; cl00814 243090003580 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243090003581 classical (c) SDRs; Region: SDR_c; cd05233 243090003582 NAD(P) binding site [chemical binding]; other site 243090003583 active site 243090003584 Integrase core domain; Region: rve; pfam00665 243090003585 Integrase core domain; Region: rve_3; pfam13683 243090003586 SLA1 homology domain 1, SHD1; Region: SHD1; pfam03983 243090003587 Tudor-like domain present in plant sequences; Region: Agenet; smart00743 243090003588 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090003589 ApbE family; Region: ApbE; pfam02424 243090003590 Transcriptional regulator; Region: Rrf2; pfam02082 243090003591 Rrf2 family protein; Region: rrf2_super; TIGR00738 243090003592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090003593 S-adenosylmethionine binding site [chemical binding]; other site 243090003594 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 243090003595 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 243090003596 putative NAD(P) binding site [chemical binding]; other site 243090003597 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 243090003598 catalytic triad [active] 243090003599 conserved cis-peptide bond; other site 243090003600 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243090003601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090003602 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090003603 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243090003604 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243090003605 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090003606 Protein of unknown function, DUF606; Region: DUF606; pfam04657 243090003607 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243090003608 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243090003609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243090003610 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 243090003611 dimerization interface [polypeptide binding]; other site 243090003612 substrate binding pocket [chemical binding]; other site 243090003613 ApbE family; Region: ApbE; pfam02424 243090003614 arginine decarboxylase; Provisional; Region: PRK05354 243090003615 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 243090003616 dimer interface [polypeptide binding]; other site 243090003617 active site 243090003618 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243090003619 catalytic residues [active] 243090003620 substrate binding site [chemical binding]; other site 243090003621 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 243090003622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090003623 Coenzyme A binding pocket [chemical binding]; other site 243090003624 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 243090003625 putative active site [active] 243090003626 catalytic triad [active] 243090003627 putative dimer interface [polypeptide binding]; other site 243090003628 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 243090003629 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 243090003630 active site 243090003631 OsmC-like protein; Region: OsmC; pfam02566 243090003632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243090003633 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243090003634 putative substrate translocation pore; other site 243090003635 cosmid pircos-b1e03/ cosmid pircos-d3f12 joining point 243090003636 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 243090003637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090003638 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243090003639 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090003640 DNA binding residues [nucleotide binding] 243090003641 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 243090003642 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243090003643 Walker A/P-loop; other site 243090003644 ATP binding site [chemical binding]; other site 243090003645 Q-loop/lid; other site 243090003646 ABC transporter signature motif; other site 243090003647 Walker B; other site 243090003648 D-loop; other site 243090003649 H-loop/switch region; other site 243090003650 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243090003651 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243090003652 ligand binding site [chemical binding]; other site 243090003653 flexible hinge region; other site 243090003654 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 243090003655 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090003656 DevC protein; Region: devC; TIGR01185 243090003657 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243090003658 FtsX-like permease family; Region: FtsX; pfam02687 243090003659 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 243090003660 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090003661 NAD binding site [chemical binding]; other site 243090003662 putative substrate binding site 2 [chemical binding]; other site 243090003663 putative substrate binding site 1 [chemical binding]; other site 243090003664 active site 243090003665 Pantoate-beta-alanine ligase; Region: PanC; cd00560 243090003666 active site 243090003667 ATP-binding site [chemical binding]; other site 243090003668 pantoate-binding site; other site 243090003669 HXXH motif; other site 243090003670 Bifunctional nuclease; Region: DNase-RNase; pfam02577 243090003671 flagellin; Validated; Region: PRK08026 243090003672 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 243090003673 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 243090003674 Suppressor of cytokine signalling; Region: SOCS; pfam12610 243090003675 Flagellar protein FliS; Region: FliS; cl00654 243090003676 Flagellar protein FliS; Region: FliS; cl00654 243090003677 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090003678 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 243090003679 NAD binding site [chemical binding]; other site 243090003680 substrate binding site [chemical binding]; other site 243090003681 homodimer interface [polypeptide binding]; other site 243090003682 active site 243090003683 arylsulfatase; Provisional; Region: PRK13759 243090003684 Sulfatase; Region: Sulfatase; pfam00884 243090003685 glycerol kinase; Provisional; Region: glpK; PRK00047 243090003686 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 243090003687 N- and C-terminal domain interface [polypeptide binding]; other site 243090003688 active site 243090003689 MgATP binding site [chemical binding]; other site 243090003690 catalytic site [active] 243090003691 metal binding site [ion binding]; metal-binding site 243090003692 glycerol binding site [chemical binding]; other site 243090003693 homotetramer interface [polypeptide binding]; other site 243090003694 homodimer interface [polypeptide binding]; other site 243090003695 FBP binding site [chemical binding]; other site 243090003696 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 243090003697 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090003698 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 243090003699 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 243090003700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243090003701 D-galactonate transporter; Region: 2A0114; TIGR00893 243090003702 putative substrate translocation pore; other site 243090003703 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090003704 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090003705 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 243090003706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 243090003707 cosmid pircos-d3f12/ cosmid pircos-a1h05 joining point 243090003708 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 243090003709 dimer interface [polypeptide binding]; other site 243090003710 metal binding site [ion binding]; metal-binding site 243090003711 substrate binding site [chemical binding]; other site 243090003712 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 243090003713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090003714 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 243090003715 putative active site [active] 243090003716 heme pocket [chemical binding]; other site 243090003717 PAS fold; Region: PAS_3; pfam08447 243090003718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090003719 putative active site [active] 243090003720 heme pocket [chemical binding]; other site 243090003721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090003722 ATP binding site [chemical binding]; other site 243090003723 Mg2+ binding site [ion binding]; other site 243090003724 G-X-G motif; other site 243090003725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090003726 active site 243090003727 phosphorylation site [posttranslational modification] 243090003728 intermolecular recognition site; other site 243090003729 dimerization interface [polypeptide binding]; other site 243090003730 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 243090003731 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 243090003732 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243090003733 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243090003734 Walker A/P-loop; other site 243090003735 ATP binding site [chemical binding]; other site 243090003736 Q-loop/lid; other site 243090003737 ABC transporter signature motif; other site 243090003738 Walker B; other site 243090003739 D-loop; other site 243090003740 H-loop/switch region; other site 243090003741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090003742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090003743 dimer interface [polypeptide binding]; other site 243090003744 phosphorylation site [posttranslational modification] 243090003745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090003746 ATP binding site [chemical binding]; other site 243090003747 Mg2+ binding site [ion binding]; other site 243090003748 G-X-G motif; other site 243090003749 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 243090003750 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 243090003751 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090003752 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090003753 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090003754 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090003755 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090003756 NHL repeat; Region: NHL; pfam01436 243090003757 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 243090003758 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 243090003759 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 243090003760 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 243090003761 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 243090003762 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 243090003763 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 243090003764 L-aspartate oxidase; Provisional; Region: PRK06175 243090003765 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 243090003766 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 243090003767 cosmid pircos-a1h05/ cosmid pircos-d1b12 joining point 243090003768 Protein of unknown function (DUF541); Region: SIMPL; cl01077 243090003769 Phosphate-selective porin O and P; Region: Porin_O_P; cl19535 243090003770 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 243090003771 active site 243090003772 catalytic triad [active] 243090003773 oxyanion hole [active] 243090003774 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 243090003775 active site 243090003776 metal binding site [ion binding]; metal-binding site 243090003777 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 243090003778 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090003779 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090003780 Sulfatase; Region: Sulfatase; pfam00884 243090003781 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 243090003782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 243090003783 ACT domain; Region: ACT_3; pfam10000 243090003784 ACT domain; Region: ACT_7; pfam13840 243090003785 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243090003786 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 243090003787 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 243090003788 putative catalytic site [active] 243090003789 putative phosphate binding site [ion binding]; other site 243090003790 putative metal binding site [ion binding]; other site 243090003791 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243090003792 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 243090003793 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090003794 Sulfatase; Region: Sulfatase; pfam00884 243090003795 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090003796 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090003797 Sulfatase; Region: Sulfatase; cl19157 243090003798 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090003799 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 243090003800 putative nucleotide binding site [chemical binding]; other site 243090003801 uridine monophosphate binding site [chemical binding]; other site 243090003802 homohexameric interface [polypeptide binding]; other site 243090003803 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 243090003804 hinge region; other site 243090003805 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 243090003806 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 243090003807 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 243090003808 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 243090003809 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 243090003810 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090003811 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090003812 active site 243090003813 ATP binding site [chemical binding]; other site 243090003814 substrate binding site [chemical binding]; other site 243090003815 activation loop (A-loop); other site 243090003816 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 243090003817 Leucine rich repeat; Region: LRR_8; pfam13855 243090003818 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 243090003819 Leucine rich repeat; Region: LRR_8; pfam13855 243090003820 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 243090003821 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 243090003822 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 243090003823 putative substrate binding pocket [chemical binding]; other site 243090003824 AC domain interface; other site 243090003825 catalytic triad [active] 243090003826 AB domain interface; other site 243090003827 interchain disulfide; other site 243090003828 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 243090003829 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 243090003830 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 243090003831 cosmid pircos-d1b12/ cosmid pircos-a1e11 joining point 243090003832 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 243090003833 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 243090003834 Collagenase; Region: DUF3656; pfam12392 243090003835 Peptidase family U32; Region: Peptidase_U32; cl03113 243090003836 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 243090003837 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 243090003838 Fe-S cluster binding site [ion binding]; other site 243090003839 active site 243090003840 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 243090003841 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 243090003842 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003843 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003844 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090003845 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090003846 HEAT repeats; Region: HEAT_2; pfam13646 243090003847 Cytochrome c; Region: Cytochrom_C; cl11414 243090003848 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243090003849 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 243090003850 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243090003851 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243090003852 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243090003853 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 243090003854 Glutamine amidotransferase class-I; Region: GATase; pfam00117 243090003855 glutamine binding [chemical binding]; other site 243090003856 catalytic triad [active] 243090003857 Protein of unknown function (DUF447); Region: DUF447; pfam04289 243090003858 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 243090003859 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 243090003860 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 243090003861 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090003862 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090003863 DTW domain; Region: DTW; cl01221 243090003864 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 243090003865 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 243090003866 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090003867 Cytochrome c; Region: Cytochrom_C; pfam00034 243090003868 Cytochrome c; Region: Cytochrom_C; pfam00034 243090003869 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090003870 Sulfatase; Region: Sulfatase; pfam00884 243090003871 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243090003872 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 243090003873 CoenzymeA binding site [chemical binding]; other site 243090003874 subunit interaction site [polypeptide binding]; other site 243090003875 PHB binding site; other site 243090003876 cosmid pircos-a1e11/ cosmid pircos-c1b05 joining point 243090003877 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 243090003878 transmembrane helices; other site 243090003879 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 243090003880 TrkA-C domain; Region: TrkA_C; pfam02080 243090003881 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 243090003882 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 243090003883 Na binding site [ion binding]; other site 243090003884 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 243090003885 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 243090003886 Protein of unknown function (DUF1556); Region: DUF1556; pfam07590 243090003887 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 243090003888 Putative transposase; Region: Y2_Tnp; pfam04986 243090003889 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 243090003890 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 243090003891 Int/Topo IB signature motif; other site 243090003892 Cytochrome c; Region: Cytochrom_C; cl11414 243090003893 Cytochrome c; Region: Cytochrom_C; pfam00034 243090003894 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090003895 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 243090003896 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243090003897 catalytic residues [active] 243090003898 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 243090003899 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090003900 ATP binding site [chemical binding]; other site 243090003901 putative Mg++ binding site [ion binding]; other site 243090003902 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090003903 nucleotide binding region [chemical binding]; other site 243090003904 ATP-binding site [chemical binding]; other site 243090003905 Helicase associated domain (HA2); Region: HA2; pfam04408 243090003906 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 243090003907 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090003908 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090003909 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090003910 Sulfatase; Region: Sulfatase; pfam00884 243090003911 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090003912 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243090003913 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 243090003914 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243090003915 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 243090003916 Protein kinase domain; Region: Pkinase; pfam00069 243090003917 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090003918 active site 243090003919 ATP binding site [chemical binding]; other site 243090003920 substrate binding site [chemical binding]; other site 243090003921 activation loop (A-loop); other site 243090003922 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 243090003923 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090003924 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090003925 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090003926 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 243090003927 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 243090003928 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 243090003929 cosmid pircos-c1b05/ cosmid pircos-a3e12 joining point 243090003930 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA_subfamily_ECM; cd01450 243090003931 integrin inhibitor binding pocket; other site 243090003932 putative vWF-collagen binding site; other site 243090003933 glycoprotein Ib (GpIb) binding site [polypeptide binding]; other site 243090003934 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 243090003935 TadE-like protein; Region: TadE; pfam07811 243090003936 TadE-like protein; Region: TadE; pfam07811 243090003937 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 243090003938 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 243090003939 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 243090003940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090003941 FeS/SAM binding site; other site 243090003942 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 243090003943 Integral membrane protein DUF95; Region: DUF95; pfam01944 243090003944 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 243090003945 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090003946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090003947 Walker A motif; other site 243090003948 ATP binding site [chemical binding]; other site 243090003949 Walker B motif; other site 243090003950 arginine finger; other site 243090003951 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243090003952 ParA-like protein; Provisional; Region: PHA02518 243090003953 P-loop; other site 243090003954 Magnesium ion binding site [ion binding]; other site 243090003955 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 243090003956 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243090003957 Transposase [DNA replication, recombination, and repair]; Region: COG5433 243090003958 TIR domain; Region: TIR_2; pfam13676 243090003959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243090003960 non-specific DNA binding site [nucleotide binding]; other site 243090003961 salt bridge; other site 243090003962 sequence-specific DNA binding site [nucleotide binding]; other site 243090003963 Cytochrome c; Region: Cytochrom_C; pfam00034 243090003964 DNA repair protein radc; Region: radc; TIGR00608 243090003965 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 243090003966 MPN+ (JAMM) motif; other site 243090003967 Zinc-binding site [ion binding]; other site 243090003968 SEFIR domain; Region: SEFIR; pfam08357 243090003969 tellurium resistance terB-like protein; Region: terB_like; cd07177 243090003970 metal binding site [ion binding]; metal-binding site 243090003971 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 243090003972 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243090003973 Transposase [DNA replication, recombination, and repair]; Region: COG5433 243090003974 Protein of unknown function (DUF1582); Region: DUF1582; pfam07621 243090003975 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 243090003976 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 243090003977 Moco binding site; other site 243090003978 metal coordination site [ion binding]; other site 243090003979 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 243090003980 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243090003981 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243090003982 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 243090003983 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090003984 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 243090003985 Penicillinase repressor; Region: Penicillinase_R; pfam03965 243090003986 Cupin domain; Region: Cupin_2; cl17218 243090003987 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 243090003988 putative catalytic site [active] 243090003989 putative metal binding site [ion binding]; other site 243090003990 putative phosphate binding site [ion binding]; other site 243090003991 cosmid pircos-a3e12/ cosmid pircos-c1b11 joining point 243090003992 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 243090003993 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243090003994 putative NAD(P) binding site [chemical binding]; other site 243090003995 catalytic Zn binding site [ion binding]; other site 243090003996 structural Zn binding site [ion binding]; other site 243090003997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090003998 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090003999 active site 243090004000 phosphorylation site [posttranslational modification] 243090004001 intermolecular recognition site; other site 243090004002 dimerization interface [polypeptide binding]; other site 243090004003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090004004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090004005 dimer interface [polypeptide binding]; other site 243090004006 phosphorylation site [posttranslational modification] 243090004007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090004008 ATP binding site [chemical binding]; other site 243090004009 Mg2+ binding site [ion binding]; other site 243090004010 G-X-G motif; other site 243090004011 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 243090004012 PSRT; Region: PSRT; pfam07636 243090004013 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243090004014 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090004015 Walker B motif; other site 243090004016 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 243090004017 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 243090004018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090004019 FeS/SAM binding site; other site 243090004020 4-alpha-glucanotransferase; Provisional; Region: PRK14508 243090004021 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090004022 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090004023 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090004024 DNA binding residues [nucleotide binding] 243090004025 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090004026 Planctomycete cytochrome C; Region: PSCyt1; cl19300 243090004027 Cytochrome c; Region: Cytochrom_C; cl11414 243090004028 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 243090004029 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 243090004030 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 243090004031 P loop; other site 243090004032 GTP binding site [chemical binding]; other site 243090004033 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 243090004034 active site 243090004035 dinuclear metal binding site [ion binding]; other site 243090004036 dimerization interface [polypeptide binding]; other site 243090004037 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243090004038 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243090004039 phosphopeptide binding site; other site 243090004040 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 243090004041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090004042 Walker A motif; other site 243090004043 ATP binding site [chemical binding]; other site 243090004044 Walker B motif; other site 243090004045 arginine finger; other site 243090004046 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243090004047 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243090004048 Protein of unknown function (DUF1598); Region: DUF1598; pfam07643 243090004049 Protein kinase domain; Region: Pkinase; pfam00069 243090004050 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090004051 active site 243090004052 ATP binding site [chemical binding]; other site 243090004053 substrate binding site [chemical binding]; other site 243090004054 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090004055 activation loop (A-loop); other site 243090004056 activation loop (A-loop); other site 243090004057 AAA ATPase domain; Region: AAA_16; pfam13191 243090004058 cosmid pircos-c1b11/ cosmid pircos-c4b01 joining point 243090004059 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 243090004060 Caldesmon; Region: Caldesmon; pfam02029 243090004061 magnesium chelatase subunit H; Provisional; Region: PLN03241 243090004062 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 243090004063 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 243090004064 catalytic nucleophile [active] 243090004065 Protein of unknown function (DUF1580); Region: DUF1580; pfam07618 243090004066 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 243090004067 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 243090004068 active site 243090004069 DNA polymerase IV; Validated; Region: PRK02406 243090004070 DNA binding site [nucleotide binding] 243090004071 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 243090004072 DinB superfamily; Region: DinB_2; pfam12867 243090004073 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 243090004074 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 243090004075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243090004076 Histidine-specific methyltransferase, SAM-dependent; Region: Methyltransf_33; pfam10017 243090004077 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090004078 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090004079 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090004080 FecR protein; Region: FecR; pfam04773 243090004081 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090004082 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 243090004083 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090004084 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090004085 DNA binding residues [nucleotide binding] 243090004086 Bacterial PH domain; Region: bPH_4; pfam06713 243090004087 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 243090004088 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090004089 ATP binding site [chemical binding]; other site 243090004090 putative Mg++ binding site [ion binding]; other site 243090004091 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090004092 nucleotide binding region [chemical binding]; other site 243090004093 ATP-binding site [chemical binding]; other site 243090004094 Helicase associated domain (HA2); Region: HA2; pfam04408 243090004095 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 243090004096 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 243090004097 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 243090004098 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 243090004099 RDD family; Region: RDD; pfam06271 243090004100 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 243090004101 active site 243090004102 zinc binding site [ion binding]; other site 243090004103 Trypsin; Region: Trypsin; pfam00089 243090004104 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090004105 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 243090004106 active site 243090004107 substrate binding site [chemical binding]; other site 243090004108 Mg2+ binding site [ion binding]; other site 243090004109 cosmid pircos-c4b01/ cosmid pircos-c3h08 joining point 243090004110 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 243090004111 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 243090004112 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 243090004113 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 243090004114 Ferritin-like; Region: Ferritin-like; pfam12902 243090004115 dinuclear metal binding motif [ion binding]; other site 243090004116 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 243090004117 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 243090004118 Zinc-dependent metalloprotease; Region: ZnMc; smart00235 243090004119 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 243090004120 active site 243090004121 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243090004122 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090004123 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 243090004124 Ferritin-like; Region: Ferritin-like; pfam12902 243090004125 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090004126 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 243090004127 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 243090004128 putative heme binding site [chemical binding]; other site 243090004129 putative substrate binding site [chemical binding]; other site 243090004130 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 243090004131 active site 243090004132 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4020; cl07907 243090004133 Transposase; Region: HTH_Tnp_1; cl17663 243090004134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 243090004135 putative transposase OrfB; Reviewed; Region: PHA02517 243090004136 HTH-like domain; Region: HTH_21; pfam13276 243090004137 Integrase core domain; Region: rve; pfam00665 243090004138 Integrase core domain; Region: rve_3; pfam13683 243090004139 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 243090004140 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 243090004141 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243090004142 FtsX-like permease family; Region: FtsX; pfam02687 243090004143 Protein of unknown function (DUF1586); Region: DUF1586; pfam07625 243090004144 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243090004145 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243090004146 Walker A/P-loop; other site 243090004147 ATP binding site [chemical binding]; other site 243090004148 Q-loop/lid; other site 243090004149 ABC transporter signature motif; other site 243090004150 Walker B; other site 243090004151 D-loop; other site 243090004152 H-loop/switch region; other site 243090004153 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090004154 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090004155 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090004156 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243090004157 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 243090004158 FtsX-like permease family; Region: FtsX; pfam02687 243090004159 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 243090004160 Planctomycete PGAMP; Region: PGAMP; pfam07644 243090004161 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 243090004162 multidrug efflux protein NorA; Provisional; Region: PRK00187 243090004163 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 243090004164 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090004165 putative ADP-binding pocket [chemical binding]; other site 243090004166 cosmid pircos-c3h08/ cosmid pircos-a3g09 joining point 243090004167 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 243090004168 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl19139 243090004169 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243090004170 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243090004171 active site 243090004172 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 243090004173 conserved hypothetical protein; Region: TIGR02284 243090004174 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 243090004175 putative ADP-ribose binding site [chemical binding]; other site 243090004176 Right handed beta helix region; Region: Beta_helix; pfam13229 243090004177 Calx-beta domain; Region: Calx-beta; cl02522 243090004178 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 243090004179 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 243090004180 tetramer interface [polypeptide binding]; other site 243090004181 heme binding pocket [chemical binding]; other site 243090004182 NADPH binding site [chemical binding]; other site 243090004183 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243090004184 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 243090004185 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 243090004186 dimer interface [polypeptide binding]; other site 243090004187 active site 243090004188 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243090004189 catalytic residues [active] 243090004190 substrate binding site [chemical binding]; other site 243090004191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 243090004192 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 243090004193 cysteine synthase; Region: PLN02565 243090004194 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 243090004195 dimer interface [polypeptide binding]; other site 243090004196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090004197 catalytic residue [active] 243090004198 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 243090004199 putative active site [active] 243090004200 QPP; Region: QPP; pfam07640 243090004201 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 243090004202 intracellular protease, PfpI family; Region: PfpI; TIGR01382 243090004203 proposed catalytic triad [active] 243090004204 conserved cys residue [active] 243090004205 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 243090004206 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243090004207 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090004208 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 243090004209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243090004210 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 243090004211 Protein of unknown function (DUF1560); Region: DUF1560; pfam07597 243090004212 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 243090004213 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 243090004214 putative NAD(P) binding site [chemical binding]; other site 243090004215 oxidoreductase; Provisional; Region: PRK06128 243090004216 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 243090004217 NAD binding site [chemical binding]; other site 243090004218 metal binding site [ion binding]; metal-binding site 243090004219 active site 243090004220 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 243090004221 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243090004222 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 243090004223 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243090004224 Cytochrome c; Region: Cytochrom_C; cl11414 243090004225 Cytochrome c; Region: Cytochrom_C; cl11414 243090004226 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 243090004227 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 243090004228 cosmid pircos-a3g09/ cosmid pircos-d3c04 joining point 243090004229 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 243090004230 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 243090004231 D-pathway; other site 243090004232 Putative ubiquinol binding site [chemical binding]; other site 243090004233 Low-spin heme (heme b) binding site [chemical binding]; other site 243090004234 Putative water exit pathway; other site 243090004235 Binuclear center (heme o3/CuB) [ion binding]; other site 243090004236 K-pathway; other site 243090004237 Putative proton exit pathway; other site 243090004238 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 243090004239 Subunit I/III interface [polypeptide binding]; other site 243090004240 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 243090004241 The cupredoxin domain of Caa3 type Cytochrome c oxidase subunit II; Region: CuRO_CcO_Caa3_II; cd04213 243090004242 oligomer interface [polypeptide binding]; other site 243090004243 CuA binuclear center [ion binding]; other site 243090004244 Cytochrome c; Region: Cytochrom_C; pfam00034 243090004245 MgtC family; Region: MgtC; pfam02308 243090004246 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 243090004247 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 243090004248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090004249 active site 243090004250 phosphorylation site [posttranslational modification] 243090004251 intermolecular recognition site; other site 243090004252 dimerization interface [polypeptide binding]; other site 243090004253 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 243090004254 nucleoside/Zn binding site; other site 243090004255 dimer interface [polypeptide binding]; other site 243090004256 catalytic motif [active] 243090004257 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 243090004258 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 243090004259 oxidoreductase; Provisional; Region: PRK12743 243090004260 classical (c) SDRs; Region: SDR_c; cd05233 243090004261 NAD(P) binding site [chemical binding]; other site 243090004262 active site 243090004263 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 243090004264 Ferritin-like domain; Region: Ferritin; pfam00210 243090004265 dimerization interface [polypeptide binding]; other site 243090004266 DPS ferroxidase diiron center [ion binding]; other site 243090004267 ion pore; other site 243090004268 Predicted membrane protein [Function unknown]; Region: COG2261 243090004269 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 243090004270 Amidohydrolase; Region: Amidohydro_2; pfam04909 243090004271 active site 243090004272 Right handed beta helix region; Region: Beta_helix; pfam13229 243090004273 flagellin; Provisional; Region: PRK12806 243090004274 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 243090004275 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 243090004276 Protein of unknown function (DUF1584); Region: PEGSRP; pfam07623 243090004277 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243090004278 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 243090004279 BON domain; Region: BON; pfam04972 243090004280 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 243090004281 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 243090004282 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243090004283 Predicted membrane protein [Function unknown]; Region: COG4325 243090004284 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 243090004285 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 243090004286 BON domain; Region: BON; pfam04972 243090004287 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 243090004288 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243090004289 Protein of unknown function (DUF1399); Region: DUF1399; pfam07173 243090004290 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243090004291 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243090004292 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 243090004293 CsbD-like; Region: CsbD; pfam05532 243090004294 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 243090004295 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 243090004296 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 243090004297 metal binding site [ion binding]; metal-binding site 243090004298 putative dimer interface [polypeptide binding]; other site 243090004299 carboxylate-amine ligase; Provisional; Region: PRK13517 243090004300 cosmid pircos-d3c04/ cosmid pircos-b2d10 joining point 243090004301 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243090004302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090004303 active site 243090004304 phosphorylation site [posttranslational modification] 243090004305 intermolecular recognition site; other site 243090004306 dimerization interface [polypeptide binding]; other site 243090004307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090004308 Walker A motif; other site 243090004309 ATP binding site [chemical binding]; other site 243090004310 Walker B motif; other site 243090004311 arginine finger; other site 243090004312 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243090004313 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 243090004314 Predicted membrane protein [Function unknown]; Region: COG2323 243090004315 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 243090004316 putative catalytic site [active] 243090004317 putative metal binding site [ion binding]; other site 243090004318 putative phosphate binding site [ion binding]; other site 243090004319 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 243090004320 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 243090004321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090004322 active site 243090004323 phosphorylation site [posttranslational modification] 243090004324 intermolecular recognition site; other site 243090004325 dimerization interface [polypeptide binding]; other site 243090004326 CheB methylesterase; Region: CheB_methylest; pfam01339 243090004327 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 243090004328 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 243090004329 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 243090004330 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090004331 PAS domain; Region: PAS_10; pfam13596 243090004332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090004333 putative active site [active] 243090004334 heme pocket [chemical binding]; other site 243090004335 PAS domain S-box; Region: sensory_box; TIGR00229 243090004336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090004337 putative active site [active] 243090004338 heme pocket [chemical binding]; other site 243090004339 histidine kinase; Provisional; Region: PRK13557 243090004340 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090004341 putative active site [active] 243090004342 heme pocket [chemical binding]; other site 243090004343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090004344 putative active site [active] 243090004345 heme pocket [chemical binding]; other site 243090004346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090004347 dimer interface [polypeptide binding]; other site 243090004348 phosphorylation site [posttranslational modification] 243090004349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090004350 ATP binding site [chemical binding]; other site 243090004351 Mg2+ binding site [ion binding]; other site 243090004352 G-X-G motif; other site 243090004353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090004354 active site 243090004355 phosphorylation site [posttranslational modification] 243090004356 intermolecular recognition site; other site 243090004357 dimerization interface [polypeptide binding]; other site 243090004358 Uncharacterized conserved protein (DUF2183); Region: DUF2183; cl19874 243090004359 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 243090004360 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090004361 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090004362 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 243090004363 aromatic arch; other site 243090004364 DCoH dimer interaction site [polypeptide binding]; other site 243090004365 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 243090004366 DCoH tetramer interaction site [polypeptide binding]; other site 243090004367 substrate binding site [chemical binding]; other site 243090004368 envelope glycoprotein I; Provisional; Region: PHA03291 243090004369 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 243090004370 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 243090004371 active site 243090004372 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243090004373 MMPL family; Region: MMPL; cl14618 243090004374 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 243090004375 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 243090004376 lipoyl-biotinyl attachment site [posttranslational modification]; other site 243090004377 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090004378 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243090004379 Outer membrane efflux protein; Region: OEP; pfam02321 243090004380 Outer membrane efflux protein; Region: OEP; pfam02321 243090004381 PrcB C-terminal; Region: PrcB_C; pfam14343 243090004382 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243090004383 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243090004384 cosmid pircos-b2d10/ cosmid pircos-c4d01 joining point 243090004385 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090004386 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090004387 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090004388 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 243090004389 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 243090004390 active site 243090004391 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 243090004392 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 243090004393 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 243090004394 Na binding site [ion binding]; other site 243090004395 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 243090004396 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 243090004397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243090004398 motif II; other site 243090004399 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243090004400 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243090004401 Domain of unknown function (DUF4465); Region: DUF4465; pfam14717 243090004402 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 243090004403 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 243090004404 active site 243090004405 dimer interface [polypeptide binding]; other site 243090004406 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 243090004407 Ligand Binding Site [chemical binding]; other site 243090004408 Molecular Tunnel; other site 243090004409 FOG: CBS domain [General function prediction only]; Region: COG0517 243090004410 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243090004411 Transporter associated domain; Region: CorC_HlyC; pfam03471 243090004412 probable rRNA maturation factor YbeY; Region: TIGR00043 243090004413 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 243090004414 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 243090004415 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243090004416 Zn2+ binding site [ion binding]; other site 243090004417 Mg2+ binding site [ion binding]; other site 243090004418 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 243090004419 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090004420 ATP binding site [chemical binding]; other site 243090004421 putative Mg++ binding site [ion binding]; other site 243090004422 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 243090004423 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 243090004424 dimer interface [polypeptide binding]; other site 243090004425 catalytic triad [active] 243090004426 peroxidatic and resolving cysteines [active] 243090004427 Recombination protein O N terminal; Region: RecO_N; pfam11967 243090004428 Recombination protein O C terminal; Region: RecO_C; pfam02565 243090004429 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 243090004430 Lipopolysaccharide-assembly; Region: LptE; cl01125 243090004431 Membrane transport protein; Region: Mem_trans; cl09117 243090004432 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 243090004433 cosmid pircos-c4d01/ cosmid pircos-a4b08 joining point 243090004434 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090004435 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 243090004436 inhibitor site; inhibition site 243090004437 active site 243090004438 dimer interface [polypeptide binding]; other site 243090004439 catalytic residue [active] 243090004440 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 243090004441 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 243090004442 RuvA N terminal domain; Region: RuvA_N; pfam01330 243090004443 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 243090004444 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 243090004445 putative RNA binding site [nucleotide binding]; other site 243090004446 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 243090004447 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090004448 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090004449 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 243090004450 NPCBM/NEW2 domain; Region: NPCBM; cl07060 243090004451 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 243090004452 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090004453 HEAT repeats; Region: HEAT_2; pfam13646 243090004454 HEAT repeats; Region: HEAT_2; pfam13646 243090004455 Cytochrome c; Region: Cytochrom_C; cl11414 243090004456 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 243090004457 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 243090004458 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243090004459 catalytic residue [active] 243090004460 Preprotein translocase subunit; Region: YajC; pfam02699 243090004461 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 243090004462 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 243090004463 Protein export membrane protein; Region: SecD_SecF; pfam02355 243090004464 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090004465 Sulfatase; Region: Sulfatase; pfam00884 243090004466 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 243090004467 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 243090004468 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 243090004469 Subunit I/III interface [polypeptide binding]; other site 243090004470 SlyX; Region: SlyX; pfam04102 243090004471 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 243090004472 ThiS interaction site; other site 243090004473 putative active site [active] 243090004474 tetramer interface [polypeptide binding]; other site 243090004475 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 243090004476 thiS-thiF/thiG interaction site; other site 243090004477 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090004478 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090004479 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 243090004480 FOG: CBS domain [General function prediction only]; Region: COG0517 243090004481 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 243090004482 large tegument protein UL36; Provisional; Region: PHA03247 243090004483 probable pectinesterase/pectinesterase inhibitor; Region: PLN02217 243090004484 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090004485 PQQ-like domain; Region: PQQ_2; pfam13360 243090004486 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090004487 Trp docking motif [polypeptide binding]; other site 243090004488 active site 243090004489 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 243090004490 active site 243090004491 putative DNA-binding cleft [nucleotide binding]; other site 243090004492 dimer interface [polypeptide binding]; other site 243090004493 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 243090004494 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 243090004495 active site 243090004496 HIGH motif; other site 243090004497 KMSKS motif; other site 243090004498 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 243090004499 tRNA binding surface [nucleotide binding]; other site 243090004500 anticodon binding site; other site 243090004501 Radial spokehead-like protein; Region: Radial_spoke; pfam04712 243090004502 OB-fold nucleic acid binding domain; Region: tRNA_anti-codon; pfam01336 243090004503 cosmid pircos-a4b08/ cosmid pircos-a2a11 joining point 243090004504 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243090004505 DNA-binding site [nucleotide binding]; DNA binding site 243090004506 RNA-binding motif; other site 243090004507 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090004508 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090004509 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090004510 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 243090004511 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243090004512 substrate binding pocket [chemical binding]; other site 243090004513 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090004514 transcription termination factor Rho; Provisional; Region: PRK12678 243090004515 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090004516 DoxX; Region: DoxX; pfam07681 243090004517 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 243090004518 Histone H1-like nucleoprotein HC2; Region: HC2; cl19298 243090004519 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243090004520 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 243090004521 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 243090004522 metal ion-dependent adhesion site (MIDAS); other site 243090004523 Uncharacterized conserved protein [Function unknown]; Region: COG1432 243090004524 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 243090004525 putative metal binding site [ion binding]; other site 243090004526 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 243090004527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243090004528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243090004529 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 243090004530 short chain dehydrogenase; Region: adh_short; pfam00106 243090004531 putative NAD(P) binding site [chemical binding]; other site 243090004532 active site 243090004533 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090004534 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090004535 active site 243090004536 ATP binding site [chemical binding]; other site 243090004537 substrate binding site [chemical binding]; other site 243090004538 activation loop (A-loop); other site 243090004539 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090004540 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 243090004541 cosmid pircos-a2a11/ cosmid pircos-b2e05 joining point 243090004542 AAA domain; Region: AAA_33; pfam13671 243090004543 AAA domain; Region: AAA_18; pfam13238 243090004544 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 243090004545 putative active site; other site 243090004546 catalytic residue [active] 243090004547 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 243090004548 putative active site [active] 243090004549 putative FMN binding site [chemical binding]; other site 243090004550 putative substrate binding site [chemical binding]; other site 243090004551 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 243090004552 Predicted kinase [General function prediction only]; Region: COG0645 243090004553 AAA domain; Region: AAA_33; pfam13671 243090004554 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 243090004555 universal stress protein UspE; Provisional; Region: PRK11175 243090004556 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243090004557 Ligand Binding Site [chemical binding]; other site 243090004558 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243090004559 Ligand Binding Site [chemical binding]; other site 243090004560 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243090004561 Ligand Binding Site [chemical binding]; other site 243090004562 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243090004563 Ligand Binding Site [chemical binding]; other site 243090004564 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 243090004565 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 243090004566 putative active site [active] 243090004567 putative FMN binding site [chemical binding]; other site 243090004568 putative substrate binding site [chemical binding]; other site 243090004569 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 243090004570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090004571 active site 243090004572 phosphorylation site [posttranslational modification] 243090004573 intermolecular recognition site; other site 243090004574 dimerization interface [polypeptide binding]; other site 243090004575 PAS domain S-box; Region: sensory_box; TIGR00229 243090004576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090004577 putative active site [active] 243090004578 heme pocket [chemical binding]; other site 243090004579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090004580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090004581 dimer interface [polypeptide binding]; other site 243090004582 phosphorylation site [posttranslational modification] 243090004583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090004584 ATP binding site [chemical binding]; other site 243090004585 Mg2+ binding site [ion binding]; other site 243090004586 G-X-G motif; other site 243090004587 PAS domain S-box; Region: sensory_box; TIGR00229 243090004588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090004589 putative active site [active] 243090004590 heme pocket [chemical binding]; other site 243090004591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090004592 dimer interface [polypeptide binding]; other site 243090004593 phosphorylation site [posttranslational modification] 243090004594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090004595 ATP binding site [chemical binding]; other site 243090004596 Mg2+ binding site [ion binding]; other site 243090004597 G-X-G motif; other site 243090004598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090004599 active site 243090004600 phosphorylation site [posttranslational modification] 243090004601 intermolecular recognition site; other site 243090004602 dimerization interface [polypeptide binding]; other site 243090004603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090004604 active site 243090004605 phosphorylation site [posttranslational modification] 243090004606 intermolecular recognition site; other site 243090004607 dimerization interface [polypeptide binding]; other site 243090004608 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243090004609 cosmid pircos-b2e05/ cosmid pircos-c3d06 joining point 243090004610 nitrous-oxide reductase; Validated; Region: PRK02888 243090004611 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 243090004612 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 243090004613 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 243090004614 Transposase, Mutator family; Region: Transposase_mut; cl19537 243090004615 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 243090004616 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 243090004617 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090004618 Sulfatase; Region: Sulfatase; pfam00884 243090004619 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090004620 Sulfatase; Region: Sulfatase; pfam00884 243090004621 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243090004622 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243090004623 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 243090004624 Predicted membrane protein [Function unknown]; Region: COG4425 243090004625 Alpha/beta-hydrolase family N-terminus; Region: Abhydrolase_9_N; pfam15420 243090004626 Alpha/beta-hydrolase family; Region: Abhydrolase_9; pfam10081 243090004627 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090004628 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090004629 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090004630 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090004631 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 243090004632 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243090004633 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 243090004634 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090004635 Sulfatase; Region: Sulfatase; pfam00884 243090004636 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 243090004637 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 243090004638 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 243090004639 putative active site [active] 243090004640 putative NTP binding site [chemical binding]; other site 243090004641 putative nucleic acid binding site [nucleotide binding]; other site 243090004642 cosmid pircos-c3d06/ cosmid pircos-c4c10 joining point 243090004643 Oxygen-sensitive ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Region: NrdD; COG1328 243090004644 Rhomboid family; Region: Rhomboid; pfam01694 243090004645 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 243090004646 methanogenesis multiheme c-type cytochrome; Region: methano7heme; TIGR04314 243090004647 Cytochrome c7; Region: Cytochrome_C7; pfam14522 243090004648 Yqey-like protein; Region: YqeY; cl17540 243090004649 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090004650 Sulfatase; Region: Sulfatase; pfam00884 243090004651 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090004652 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090004653 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090004654 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090004655 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090004656 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090004657 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090004658 cosmid pircos-c4c10/ cosmid gap joining point 243090004659 FecR protein; Region: FecR; pfam04773 243090004660 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 243090004661 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090004662 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 243090004663 Right handed beta helix region; Region: Beta_helix; pfam13229 243090004664 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 243090004665 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243090004666 FtsX-like permease family; Region: FtsX; pfam02687 243090004667 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243090004668 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243090004669 Walker A/P-loop; other site 243090004670 ATP binding site [chemical binding]; other site 243090004671 Q-loop/lid; other site 243090004672 ABC transporter signature motif; other site 243090004673 Walker B; other site 243090004674 D-loop; other site 243090004675 H-loop/switch region; other site 243090004676 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 243090004677 SmpB-tmRNA interface; other site 243090004678 lipoyl synthase; Provisional; Region: PRK05481 243090004679 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090004680 FeS/SAM binding site; other site 243090004681 Predicted permease [General function prediction only]; Region: COG2985 243090004682 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 243090004683 TrkA-C domain; Region: TrkA_C; pfam02080 243090004684 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 243090004685 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243090004686 MMPL family; Region: MMPL; cl14618 243090004687 MMPL family; Region: MMPL; cl14618 243090004688 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090004689 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090004690 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090004691 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243090004692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243090004693 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 243090004694 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 243090004695 Di-iron ligands [ion binding]; other site 243090004696 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243090004697 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 243090004698 motif 1; other site 243090004699 dimer interface [polypeptide binding]; other site 243090004700 active site 243090004701 motif 2; other site 243090004702 motif 3; other site 243090004703 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 243090004704 amphipathic channel; other site 243090004705 Asn-Pro-Ala signature motifs; other site 243090004706 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 243090004707 active site 243090004708 catalytic triad [active] 243090004709 oxyanion hole [active] 243090004710 Sulfatase; Region: Sulfatase; pfam00884 243090004711 arylsulfatase; Provisional; Region: PRK13759 243090004712 Protein of unknown function (DUF1580); Region: DUF1580; pfam07618 243090004713 cosmid gap/ cosmid pircos-b2e03 joining point 243090004714 Flavodoxin domain; Region: Flavodoxin_5; cl17428 243090004715 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 243090004716 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243090004717 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243090004718 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 243090004719 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 243090004720 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 243090004721 active site 243090004722 catalytic site [active] 243090004723 putative phosphoketolase; Provisional; Region: PRK05261 243090004724 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 243090004725 TPP-binding site; other site 243090004726 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 243090004727 XFP C-terminal domain; Region: XFP_C; pfam09363 243090004728 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243090004729 catalytic core [active] 243090004730 alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305 243090004731 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243090004732 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 243090004733 alpha subunit interaction interface [polypeptide binding]; other site 243090004734 Walker A motif; other site 243090004735 ATP binding site [chemical binding]; other site 243090004736 Walker B motif; other site 243090004737 inhibitor binding site; inhibition site 243090004738 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243090004739 F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228 243090004740 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 243090004741 gamma subunit interface [polypeptide binding]; other site 243090004742 epsilon subunit interface [polypeptide binding]; other site 243090004743 LBP interface [polypeptide binding]; other site 243090004744 F0F1-ATPase subunit, putative; Region: ATPase_gene1; TIGR02230 243090004745 F1/F0 ATPase, Methanosarcina type, subunit 2; Region: F1F0_chp_2; TIGR03165 243090004746 alternate F1F0 ATPase, F0 subunit A; Region: altF1_A; TIGR03306 243090004747 alternate F1F0 ATPase, F0 subunit C; Region: alt_F1F0_F0_C; TIGR03322 243090004748 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 243090004749 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090004750 ATP synthase delta (OSCP) subunit; Region: OSCP; cl17210 243090004751 alternate F1F0 ATPase, F1 subunit alpha; Region: alt_F1F0_F1_al; TIGR03324 243090004752 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243090004753 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090004754 Walker A motif; other site 243090004755 ATP binding site [chemical binding]; other site 243090004756 Walker B motif; other site 243090004757 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243090004758 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 243090004759 core domain interface [polypeptide binding]; other site 243090004760 delta subunit interface [polypeptide binding]; other site 243090004761 epsilon subunit interface [polypeptide binding]; other site 243090004762 DsrE/DsrF-like family; Region: DrsE; pfam02635 243090004763 Yip1 domain; Region: Yip1; pfam04893 243090004764 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243090004765 EamA-like transporter family; Region: EamA; pfam00892 243090004766 ribonuclease III; Reviewed; Region: rnc; PRK00102 243090004767 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 243090004768 dimerization interface [polypeptide binding]; other site 243090004769 active site 243090004770 metal binding site [ion binding]; metal-binding site 243090004771 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 243090004772 dsRNA binding site [nucleotide binding]; other site 243090004773 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 243090004774 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 243090004775 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 243090004776 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 243090004777 metal binding site [ion binding]; metal-binding site 243090004778 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 243090004779 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 243090004780 protein binding site [polypeptide binding]; other site 243090004781 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 243090004782 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 243090004783 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 243090004784 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 243090004785 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 243090004786 active site 243090004787 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090004788 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090004789 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 243090004790 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 243090004791 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 243090004792 O-Antigen ligase; Region: Wzy_C; pfam04932 243090004793 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243090004794 catalytic residues [active] 243090004795 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243090004796 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243090004797 phosphopeptide binding site; other site 243090004798 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 243090004799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090004800 FeS/SAM binding site; other site 243090004801 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 243090004802 HTH domain; Region: HTH_11; pfam08279 243090004803 WYL domain; Region: WYL; pfam13280 243090004804 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243090004805 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243090004806 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 243090004807 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 243090004808 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 243090004809 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 243090004810 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 243090004811 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 243090004812 cosmid pircos-b2e03/ cosmid pircos-a4e11 joining point 243090004813 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243090004814 classical (c) SDRs; Region: SDR_c; cd05233 243090004815 NAD(P) binding site [chemical binding]; other site 243090004816 active site 243090004817 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 243090004818 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 243090004819 NADP binding site [chemical binding]; other site 243090004820 Predicted deacylase [General function prediction only]; Region: COG3608 243090004821 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 243090004822 putative active site [active] 243090004823 Zn binding site [ion binding]; other site 243090004824 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090004825 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090004826 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090004827 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090004828 Prokaryotic N-terminal methylation site; Region: N_methyl_3; pfam13633 243090004829 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090004830 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090004831 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 243090004832 active site 243090004833 catalytic triad [active] 243090004834 oxyanion hole [active] 243090004835 sensor protein RstB; Provisional; Region: PRK10604 243090004836 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243090004837 dimerization interface [polypeptide binding]; other site 243090004838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090004839 dimer interface [polypeptide binding]; other site 243090004840 phosphorylation site [posttranslational modification] 243090004841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090004842 ATP binding site [chemical binding]; other site 243090004843 Mg2+ binding site [ion binding]; other site 243090004844 G-X-G motif; other site 243090004845 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 243090004846 homopentamer interface [polypeptide binding]; other site 243090004847 active site 243090004848 transcription termination factor Rho; Provisional; Region: rho; PRK09376 243090004849 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 243090004850 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 243090004851 RNA binding site [nucleotide binding]; other site 243090004852 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 243090004853 multimer interface [polypeptide binding]; other site 243090004854 Walker A motif; other site 243090004855 ATP binding site [chemical binding]; other site 243090004856 Walker B motif; other site 243090004857 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 243090004858 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243090004859 minor groove reading motif; other site 243090004860 helix-hairpin-helix signature motif; other site 243090004861 substrate binding pocket [chemical binding]; other site 243090004862 active site 243090004863 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 243090004864 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 243090004865 Domain of unknown function (DUF303); Region: DUF303; pfam03629 243090004866 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 243090004867 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 243090004868 active site 243090004869 catalytic residues [active] 243090004870 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 243090004871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090004872 Coenzyme A binding pocket [chemical binding]; other site 243090004873 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 243090004874 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243090004875 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 243090004876 active site 243090004877 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090004878 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090004879 active site 243090004880 ATP binding site [chemical binding]; other site 243090004881 substrate binding site [chemical binding]; other site 243090004882 activation loop (A-loop); other site 243090004883 AAA domain; Region: AAA_22; pfam13401 243090004884 Uncharacterized conserved protein [Function unknown]; Region: COG1262 243090004885 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 243090004886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090004887 S-adenosylmethionine binding site [chemical binding]; other site 243090004888 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090004889 cosmid pircos-a4e11/ cosmid pircos-a4e07 joining point 243090004890 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243090004891 active site 2 [active] 243090004892 active site 1 [active] 243090004893 choline dehydrogenase; Region: betA; TIGR01810 243090004894 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090004895 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 243090004896 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243090004897 Sodium/glutamate symporter; Region: Glt_symporter; cl19414 243090004898 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 243090004899 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 243090004900 active site 243090004901 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243090004902 active site 243090004903 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 243090004904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243090004905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243090004906 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090004907 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090004908 ABC transporter ATPase component; Reviewed; Region: PRK11147 243090004909 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243090004910 ABC transporter; Region: ABC_tran_2; pfam12848 243090004911 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243090004912 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 243090004913 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 243090004914 Walker A/P-loop; other site 243090004915 ATP binding site [chemical binding]; other site 243090004916 Q-loop/lid; other site 243090004917 ABC transporter signature motif; other site 243090004918 Walker B; other site 243090004919 D-loop; other site 243090004920 H-loop/switch region; other site 243090004921 Predicted membrane protein [Function unknown]; Region: COG3428 243090004922 Bacterial PH domain; Region: bPH_2; pfam03703 243090004923 Bacterial PH domain; Region: bPH_2; cl01348 243090004924 Bacterial PH domain; Region: bPH_2; pfam03703 243090004925 Bacterial PH domain; Region: bPH_2; cl01348 243090004926 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090004927 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090004928 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090004929 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090004930 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090004931 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090004932 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090004933 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090004934 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090004935 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090004936 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 243090004937 FecR protein; Region: FecR; pfam04773 243090004938 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 243090004939 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090004940 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090004941 DNA binding residues [nucleotide binding] 243090004942 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 243090004943 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 243090004944 putative metal binding site [ion binding]; other site 243090004945 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 243090004946 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090004947 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090004948 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090004949 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 243090004950 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243090004951 minor groove reading motif; other site 243090004952 helix-hairpin-helix signature motif; other site 243090004953 substrate binding pocket [chemical binding]; other site 243090004954 active site 243090004955 serine O-acetyltransferase; Region: cysE; TIGR01172 243090004956 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 243090004957 trimer interface [polypeptide binding]; other site 243090004958 active site 243090004959 substrate binding site [chemical binding]; other site 243090004960 CoA binding site [chemical binding]; other site 243090004961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243090004962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243090004963 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 243090004964 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 243090004965 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 243090004966 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090004967 cosmid pircos-a4e07/ cosmid pircos-a2f02 joining point 243090004968 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243090004969 CHAT domain; Region: CHAT; cl19248 243090004970 Flagellar P-ring protein; Region: FlgI; cl19280 243090004971 HEAT repeats; Region: HEAT_2; pfam13646 243090004972 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243090004973 Cytochrome c; Region: Cytochrom_C; cl11414 243090004974 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 243090004975 active site 243090004976 dimerization interface [polypeptide binding]; other site 243090004977 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 243090004978 active site 243090004979 Predicted membrane protein [Function unknown]; Region: COG2259 243090004980 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090004981 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090004982 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 243090004983 catalytic site [active] 243090004984 BNR repeat-like domain; Region: BNR_2; pfam13088 243090004985 Asp-box motif; other site 243090004986 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090004987 Sulfatase; Region: Sulfatase; pfam00884 243090004988 Protein of unknown function (DUF1581); Region: DUF1581; pfam07619 243090004989 Protein of unknown function (DUF1583); Region: DUF1583; pfam07622 243090004990 threonine dehydratase; Region: THD1; TIGR02079 243090004991 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 243090004992 tetramer interface [polypeptide binding]; other site 243090004993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090004994 catalytic residue [active] 243090004995 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 243090004996 putative Ile/Val binding site [chemical binding]; other site 243090004997 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 243090004998 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 243090004999 Walker A/P-loop; other site 243090005000 ATP binding site [chemical binding]; other site 243090005001 Q-loop/lid; other site 243090005002 ABC transporter signature motif; other site 243090005003 Walker B; other site 243090005004 D-loop; other site 243090005005 H-loop/switch region; other site 243090005006 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 243090005007 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 243090005008 Catalytic site [active] 243090005009 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243090005010 DinB superfamily; Region: DinB_2; pfam12867 243090005011 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 243090005012 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 243090005013 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 243090005014 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 243090005015 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 243090005016 BON domain; Region: BON; pfam04972 243090005017 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243090005018 cosmid pircos-a2f02/ cosmid pircos-c4b05 joining point 243090005019 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 243090005020 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243090005021 active site 243090005022 phosphorylation site [posttranslational modification] 243090005023 intermolecular recognition site; other site 243090005024 dimerization interface [polypeptide binding]; other site 243090005025 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 243090005026 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 243090005027 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 243090005028 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 243090005029 active site 243090005030 catalytic triad [active] 243090005031 dimer interface [polypeptide binding]; other site 243090005032 prolyl-tRNA synthetase; Provisional; Region: PRK08661 243090005033 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 243090005034 dimer interface [polypeptide binding]; other site 243090005035 motif 1; other site 243090005036 active site 243090005037 motif 2; other site 243090005038 motif 3; other site 243090005039 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 243090005040 anticodon binding site; other site 243090005041 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 243090005042 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 243090005043 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 243090005044 catalytic site [active] 243090005045 subunit interface [polypeptide binding]; other site 243090005046 GTP-binding protein YchF; Reviewed; Region: PRK09601 243090005047 YchF GTPase; Region: YchF; cd01900 243090005048 G1 box; other site 243090005049 GTP/Mg2+ binding site [chemical binding]; other site 243090005050 Switch I region; other site 243090005051 G2 box; other site 243090005052 Switch II region; other site 243090005053 G3 box; other site 243090005054 G4 box; other site 243090005055 G5 box; other site 243090005056 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 243090005057 Phosphate-selective porin O and P; Region: Porin_O_P; cl19535 243090005058 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 243090005059 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090005060 Sulfatase; Region: Sulfatase; pfam00884 243090005061 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 243090005062 trehalose synthase; Region: treS_nterm; TIGR02456 243090005063 active site 243090005064 catalytic site [active] 243090005065 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 243090005066 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 243090005067 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 243090005068 putative ADP-binding pocket [chemical binding]; other site 243090005069 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 243090005070 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 243090005071 putative substrate binding site [chemical binding]; other site 243090005072 putative ATP binding site [chemical binding]; other site 243090005073 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 243090005074 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243090005075 active site 243090005076 motif I; other site 243090005077 motif II; other site 243090005078 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 243090005079 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 243090005080 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 243090005081 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 243090005082 catalytic site [active] 243090005083 active site 243090005084 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 243090005085 SurA N-terminal domain; Region: SurA_N_3; cl07813 243090005086 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243090005087 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 243090005088 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 243090005089 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 243090005090 conserved cys residue [active] 243090005091 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 243090005092 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 243090005093 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 243090005094 cosmid pircos-c4b05/ cosmid pircos-b1c10 joining point 243090005095 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 243090005096 Protein of unknown function (DUF952); Region: DUF952; pfam06108 243090005097 Peptidase family M41; Region: Peptidase_M41; pfam01434 243090005098 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243090005099 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090005100 Haemolysin-III related; Region: HlyIII; pfam03006 243090005101 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 243090005102 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090005103 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090005104 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090005105 structural tetrad; other site 243090005106 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 243090005107 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090005108 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090005109 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090005110 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 243090005111 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 243090005112 SWIM zinc finger; Region: SWIM; pfam04434 243090005113 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 243090005114 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090005115 ATP binding site [chemical binding]; other site 243090005116 putative Mg++ binding site [ion binding]; other site 243090005117 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 243090005118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090005119 nucleotide binding region [chemical binding]; other site 243090005120 ATP-binding site [chemical binding]; other site 243090005121 Homo sapiens CSTP1 and related proteins, metallophosphatase domain; Region: MPP_CSTP1; cd07395 243090005122 putative active site [active] 243090005123 putative metal binding site [ion binding]; other site 243090005124 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 243090005125 PQQ-like domain; Region: PQQ_2; pfam13360 243090005126 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090005127 Trp docking motif [polypeptide binding]; other site 243090005128 active site 243090005129 PAS domain; Region: PAS_9; pfam13426 243090005130 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090005131 putative active site [active] 243090005132 heme pocket [chemical binding]; other site 243090005133 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243090005134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090005135 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 243090005136 inhibitor site; inhibition site 243090005137 active site 243090005138 dimer interface [polypeptide binding]; other site 243090005139 catalytic residue [active] 243090005140 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 243090005141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090005142 Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994 243090005143 active site 243090005144 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090005145 Sulfatase; Region: Sulfatase; pfam00884 243090005146 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090005147 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 243090005148 arylsulfatase; Provisional; Region: PRK13759 243090005149 Sulfatase; Region: Sulfatase; pfam00884 243090005150 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090005151 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090005152 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090005153 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090005154 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090005155 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090005156 Sulfatase; Region: Sulfatase; pfam00884 243090005157 cosmid pircos-b1c10/ cosmid pircos-b2e11 joining point 243090005158 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090005159 Sulfatase; Region: Sulfatase; pfam00884 243090005160 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 243090005161 N-terminus of Esterase_SGNH_hydro-type; Region: GxDLY; pfam14607 243090005162 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 243090005163 active site 243090005164 catalytic triad [active] 243090005165 oxyanion hole [active] 243090005166 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 243090005167 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 243090005168 putative amphipathic alpha helix; other site 243090005169 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090005170 Sulfatase; Region: Sulfatase; pfam00884 243090005171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090005172 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243090005173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090005174 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 243090005175 Pectate lyase; Region: Pec_lyase_C; cl01593 243090005176 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 243090005177 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 243090005178 Amb_all domain; Region: Amb_all; smart00656 243090005179 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 243090005180 active site 243090005181 dimer interface [polypeptide binding]; other site 243090005182 magnesium binding site [ion binding]; other site 243090005183 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 243090005184 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243090005185 putative NAD(P) binding site [chemical binding]; other site 243090005186 catalytic Zn binding site [ion binding]; other site 243090005187 structural Zn binding site [ion binding]; other site 243090005188 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090005189 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090005190 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 243090005191 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 243090005192 active site 243090005193 catalytic triad [active] 243090005194 oxyanion hole [active] 243090005195 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090005196 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090005197 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090005198 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090005199 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 243090005200 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243090005201 active site 243090005202 metal binding site [ion binding]; metal-binding site 243090005203 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 243090005204 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090005205 FeS/SAM binding site; other site 243090005206 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243090005207 iron-sulfur cluster [ion binding]; other site 243090005208 [2Fe-2S] cluster binding site [ion binding]; other site 243090005209 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 243090005210 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 243090005211 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 243090005212 Part of AAA domain; Region: AAA_19; pfam13245 243090005213 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 243090005214 cosmid pircos-b2e11/ cosmid pircos-d2c12 joining point 243090005215 Transposase IS200 like; Region: Y1_Tnp; pfam01797 243090005216 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090005217 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 243090005218 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090005219 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 243090005220 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 243090005221 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090005222 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090005223 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 243090005224 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 243090005225 catalytic residues [active] 243090005226 catalytic nucleophile [active] 243090005227 Recombinase; Region: Recombinase; pfam07508 243090005228 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 243090005229 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 243090005230 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 243090005231 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090005232 Sulfatase; Region: Sulfatase; pfam00884 243090005233 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090005234 Trp docking motif [polypeptide binding]; other site 243090005235 PQQ-like domain; Region: PQQ_2; pfam13360 243090005236 active site 243090005237 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090005238 Sulfatase; Region: Sulfatase; cl19157 243090005239 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 243090005240 prephenate dehydrogenase; Validated; Region: PRK08507 243090005241 cosmid pircos-d2c12/ cosmid gap joining point 243090005242 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 243090005243 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 243090005244 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 243090005245 dimerization interface [polypeptide binding]; other site 243090005246 ATP binding site [chemical binding]; other site 243090005247 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 243090005248 dimerization interface [polypeptide binding]; other site 243090005249 ATP binding site [chemical binding]; other site 243090005250 cosmid gap/ cosmid pircos-b3b04 joining point 243090005251 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090005252 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090005253 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090005254 MAEBL; Provisional; Region: PTZ00121 243090005255 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 243090005256 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 243090005257 N- and C-terminal domain interface [polypeptide binding]; other site 243090005258 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 243090005259 active site 243090005260 putative catalytic site [active] 243090005261 metal binding site [ion binding]; metal-binding site 243090005262 ATP binding site [chemical binding]; other site 243090005263 carbohydrate binding site [chemical binding]; other site 243090005264 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 243090005265 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 243090005266 RPB12 interaction site [polypeptide binding]; other site 243090005267 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 243090005268 RPB1 interaction site [polypeptide binding]; other site 243090005269 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 243090005270 RPB10 interaction site [polypeptide binding]; other site 243090005271 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 243090005272 RPB11 interaction site [polypeptide binding]; other site 243090005273 RPB3 interaction site [polypeptide binding]; other site 243090005274 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 243090005275 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 243090005276 beta and beta' interface [polypeptide binding]; other site 243090005277 beta' and sigma factor interface [polypeptide binding]; other site 243090005278 Zn-binding [ion binding]; other site 243090005279 active site region [active] 243090005280 catalytic site [active] 243090005281 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 243090005282 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 243090005283 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 243090005284 G-loop; other site 243090005285 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 243090005286 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 243090005287 DNA binding site [nucleotide binding] 243090005288 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090005289 Sulfatase; Region: Sulfatase; pfam00884 243090005290 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 243090005291 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090005292 FecR protein; Region: FecR; pfam04773 243090005293 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090005294 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090005295 Sulfatase; Region: Sulfatase; pfam00884 243090005296 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243090005297 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090005298 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090005299 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 243090005300 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090005301 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090005302 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142 243090005303 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243090005304 Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; Region: RNase_H_like; cl14782 243090005305 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 243090005306 elongation factor G; Reviewed; Region: PRK00007 243090005307 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 243090005308 G1 box; other site 243090005309 putative GEF interaction site [polypeptide binding]; other site 243090005310 GTP/Mg2+ binding site [chemical binding]; other site 243090005311 Switch I region; other site 243090005312 G2 box; other site 243090005313 G3 box; other site 243090005314 Switch II region; other site 243090005315 G4 box; other site 243090005316 G5 box; other site 243090005317 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 243090005318 Elongation Factor G, domain II; Region: EFG_II; pfam14492 243090005319 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 243090005320 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 243090005321 purine nucleoside phosphorylase; Provisional; Region: PRK08202 243090005322 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 243090005323 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 243090005324 domain_subunit interface; other site 243090005325 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243090005326 metal ion-dependent adhesion site (MIDAS); other site 243090005327 S-adenosylmethionine synthetase; Validated; Region: PRK05250 243090005328 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 243090005329 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 243090005330 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 243090005331 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 243090005332 putative phosphoesterase; Region: acc_ester; TIGR03729 243090005333 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243090005334 active site 243090005335 metal binding site [ion binding]; metal-binding site 243090005336 cosmid pircos-b3b04/ cosmid pircos-a3d12 joining point 243090005337 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090005338 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090005339 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090005340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090005341 active site 243090005342 phosphorylation site [posttranslational modification] 243090005343 intermolecular recognition site; other site 243090005344 dimerization interface [polypeptide binding]; other site 243090005345 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243090005346 metal binding site [ion binding]; metal-binding site 243090005347 active site 243090005348 I-site; other site 243090005349 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243090005350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090005351 active site 243090005352 phosphorylation site [posttranslational modification] 243090005353 intermolecular recognition site; other site 243090005354 dimerization interface [polypeptide binding]; other site 243090005355 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090005356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090005357 active site 243090005358 phosphorylation site [posttranslational modification] 243090005359 intermolecular recognition site; other site 243090005360 dimerization interface [polypeptide binding]; other site 243090005361 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090005362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090005363 active site 243090005364 phosphorylation site [posttranslational modification] 243090005365 intermolecular recognition site; other site 243090005366 dimerization interface [polypeptide binding]; other site 243090005367 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090005368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090005369 active site 243090005370 phosphorylation site [posttranslational modification] 243090005371 intermolecular recognition site; other site 243090005372 dimerization interface [polypeptide binding]; other site 243090005373 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090005374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090005375 active site 243090005376 phosphorylation site [posttranslational modification] 243090005377 intermolecular recognition site; other site 243090005378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090005379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090005380 dimer interface [polypeptide binding]; other site 243090005381 phosphorylation site [posttranslational modification] 243090005382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090005383 ATP binding site [chemical binding]; other site 243090005384 Mg2+ binding site [ion binding]; other site 243090005385 G-X-G motif; other site 243090005386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090005387 active site 243090005388 phosphorylation site [posttranslational modification] 243090005389 intermolecular recognition site; other site 243090005390 dimerization interface [polypeptide binding]; other site 243090005391 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090005392 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090005393 structural tetrad; other site 243090005394 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243090005395 MMPL family; Region: MMPL; cl14618 243090005396 MMPL family; Region: MMPL; cl14618 243090005397 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090005398 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090005399 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 243090005400 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090005401 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 243090005402 Right handed beta helix region; Region: Beta_helix; pfam13229 243090005403 hypothetical protein; Validated; Region: PRK00110 243090005404 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 243090005405 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 243090005406 translation initiation factor IF-2; Validated; Region: infB; PRK05306 243090005407 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 243090005408 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 243090005409 G1 box; other site 243090005410 putative GEF interaction site [polypeptide binding]; other site 243090005411 GTP/Mg2+ binding site [chemical binding]; other site 243090005412 Switch I region; other site 243090005413 G2 box; other site 243090005414 G3 box; other site 243090005415 Switch II region; other site 243090005416 G4 box; other site 243090005417 G5 box; other site 243090005418 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 243090005419 Translation-initiation factor 2; Region: IF-2; pfam11987 243090005420 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 243090005421 NusA N-terminal domain; Region: NusA_N; pfam08529 243090005422 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 243090005423 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 243090005424 RNA binding site [nucleotide binding]; other site 243090005425 homodimer interface [polypeptide binding]; other site 243090005426 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 243090005427 G-X-X-G motif; other site 243090005428 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 243090005429 G-X-X-G motif; other site 243090005430 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 243090005431 MARCKS family; Region: MARCKS; pfam02063 243090005432 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 243090005433 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 243090005434 Type II secretion system (T2SS), protein J; Region: T2SJ; cl19722 243090005435 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090005436 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 243090005437 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 243090005438 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 243090005439 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 243090005440 active site 243090005441 Right handed beta helix region; Region: Beta_helix; pfam13229 243090005442 cosmid pircos-a3d12/ cosmid pircos-a2c09 joining point 243090005443 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 243090005444 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 243090005445 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 243090005446 active site 243090005447 HIGH motif; other site 243090005448 KMSKS motif; other site 243090005449 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 243090005450 tRNA binding surface [nucleotide binding]; other site 243090005451 anticodon binding site; other site 243090005452 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 243090005453 dimer interface [polypeptide binding]; other site 243090005454 putative tRNA-binding site [nucleotide binding]; other site 243090005455 cosmid pircos-a2c09/ cosmid pircos-c4e10 joining point 243090005456 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090005457 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090005458 Trp docking motif [polypeptide binding]; other site 243090005459 active site 243090005460 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 243090005461 substrate binding site [chemical binding]; other site 243090005462 active site 243090005463 catalytic residues [active] 243090005464 heterodimer interface [polypeptide binding]; other site 243090005465 large tegument protein UL36; Provisional; Region: PHA03247 243090005466 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 243090005467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090005468 Walker A motif; other site 243090005469 ATP binding site [chemical binding]; other site 243090005470 Walker B motif; other site 243090005471 arginine finger; other site 243090005472 Peptidase family M41; Region: Peptidase_M41; pfam01434 243090005473 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 243090005474 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 243090005475 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 243090005476 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 243090005477 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 243090005478 RIP metalloprotease RseP; Region: TIGR00054 243090005479 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 243090005480 active site 243090005481 active site 243090005482 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 243090005483 protein binding site [polypeptide binding]; other site 243090005484 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 243090005485 protein binding site [polypeptide binding]; other site 243090005486 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 243090005487 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 243090005488 putative substrate binding region [chemical binding]; other site 243090005489 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243090005490 EamA-like transporter family; Region: EamA; pfam00892 243090005491 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243090005492 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 243090005493 Strictosidine synthase; Region: Str_synth; cl19733 243090005494 Uncharacterized conserved protein [Function unknown]; Region: COG1262 243090005495 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 243090005496 ECF sigma factor; Region: Sigma70_ECF; pfam07638 243090005497 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090005498 DNA binding residues [nucleotide binding] 243090005499 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090005500 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090005501 active site 243090005502 ATP binding site [chemical binding]; other site 243090005503 substrate binding site [chemical binding]; other site 243090005504 activation loop (A-loop); other site 243090005505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090005506 TPR motif; other site 243090005507 binding surface 243090005508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090005509 TPR motif; other site 243090005510 binding surface 243090005511 TPR repeat; Region: TPR_11; pfam13414 243090005512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090005513 binding surface 243090005514 TPR motif; other site 243090005515 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090005516 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 243090005517 cosmid pircos-c4e10/ cosmid pircos-c4h11 joining point 243090005518 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 243090005519 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243090005520 substrate binding pocket [chemical binding]; other site 243090005521 membrane-bound complex binding site; other site 243090005522 hinge residues; other site 243090005523 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 243090005524 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 243090005525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243090005526 Walker A/P-loop; other site 243090005527 ATP binding site [chemical binding]; other site 243090005528 Q-loop/lid; other site 243090005529 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 243090005530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243090005531 ABC transporter signature motif; other site 243090005532 Walker B; other site 243090005533 D-loop; other site 243090005534 H-loop/switch region; other site 243090005535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243090005536 Walker A/P-loop; other site 243090005537 ATP binding site [chemical binding]; other site 243090005538 Q-loop/lid; other site 243090005539 ABC transporter signature motif; other site 243090005540 Walker B; other site 243090005541 D-loop; other site 243090005542 H-loop/switch region; other site 243090005543 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 243090005544 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090005545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 243090005546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090005547 TPR motif; other site 243090005548 Abhydrolase family; Region: Abhydrolase_7; pfam12715 243090005549 TM2 domain; Region: TM2; pfam05154 243090005550 TM2 domain; Region: TM2; pfam05154 243090005551 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 243090005552 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 243090005553 G1 box; other site 243090005554 GTP/Mg2+ binding site [chemical binding]; other site 243090005555 Switch I region; other site 243090005556 G2 box; other site 243090005557 Switch II region; other site 243090005558 G3 box; other site 243090005559 G4 box; other site 243090005560 G5 box; other site 243090005561 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 243090005562 G1 box; other site 243090005563 GTP/Mg2+ binding site [chemical binding]; other site 243090005564 Switch I region; other site 243090005565 G2 box; other site 243090005566 G3 box; other site 243090005567 Switch II region; other site 243090005568 G4 box; other site 243090005569 G5 box; other site 243090005570 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 243090005571 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 243090005572 Fe-S cluster binding site [ion binding]; other site 243090005573 active site 243090005574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 243090005575 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 243090005576 Zn binding site [ion binding]; other site 243090005577 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243090005578 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243090005579 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243090005580 P-loop; other site 243090005581 Magnesium ion binding site [ion binding]; other site 243090005582 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090005583 ribonuclease E; Reviewed; Region: rne; PRK10811 243090005584 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 243090005585 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 243090005586 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 243090005587 FliG N-terminal domain; Region: FliG_N; pfam14842 243090005588 FliG middle domain; Region: FliG_M; pfam14841 243090005589 FliG C-terminal domain; Region: FliG_C; pfam01706 243090005590 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090005591 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 243090005592 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090005593 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 243090005594 PA14 domain; Region: PA14; pfam07691 243090005595 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 243090005596 B12 binding site [chemical binding]; other site 243090005597 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090005598 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243090005599 FeS/SAM binding site; other site 243090005600 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 243090005601 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 243090005602 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 243090005603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090005604 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 243090005605 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 243090005606 active site 243090005607 dimer interface [polypeptide binding]; other site 243090005608 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 243090005609 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 243090005610 active site 243090005611 FMN binding site [chemical binding]; other site 243090005612 substrate binding site [chemical binding]; other site 243090005613 3Fe-4S cluster binding site [ion binding]; other site 243090005614 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 243090005615 domain interface; other site 243090005616 cosmid pircos-c4h11/ cosmid pircos-d2d04 joining point 243090005617 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243090005618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243090005619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243090005620 dimerization interface [polypeptide binding]; other site 243090005621 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 243090005622 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090005623 Prokaryotic N-terminal methylation site; Region: N_methyl_3; pfam13633 243090005624 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090005625 Protein of unknown function (DUF1570); Region: DUF1570; pfam07607 243090005626 Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528 243090005627 active site residue [active] 243090005628 NAD synthetase; Reviewed; Region: nadE; PRK02628 243090005629 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 243090005630 multimer interface [polypeptide binding]; other site 243090005631 active site 243090005632 catalytic triad [active] 243090005633 protein interface 1 [polypeptide binding]; other site 243090005634 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 243090005635 homodimer interface [polypeptide binding]; other site 243090005636 NAD binding pocket [chemical binding]; other site 243090005637 ATP binding pocket [chemical binding]; other site 243090005638 Mg binding site [ion binding]; other site 243090005639 active-site loop [active] 243090005640 putative protein phosphatase; Region: PHA02239 243090005641 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 243090005642 active site 243090005643 metal binding site [ion binding]; metal-binding site 243090005644 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 243090005645 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 243090005646 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 243090005647 dimer interface [polypeptide binding]; other site 243090005648 active site 243090005649 CoA binding pocket [chemical binding]; other site 243090005650 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 243090005651 trigger factor; Region: tig; TIGR00115 243090005652 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 243090005653 hypothetical protein; Provisional; Region: PRK02227 243090005654 ribonuclease D; Region: rnd; TIGR01388 243090005655 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 243090005656 catalytic site [active] 243090005657 putative active site [active] 243090005658 putative substrate binding site [chemical binding]; other site 243090005659 HRDC domain; Region: HRDC; pfam00570 243090005660 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 243090005661 Substrate binding site [chemical binding]; other site 243090005662 AAA domain; Region: AAA_26; pfam13500 243090005663 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 243090005664 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 243090005665 putative active site; other site 243090005666 catalytic triad [active] 243090005667 putative dimer interface [polypeptide binding]; other site 243090005668 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 243090005669 active site 243090005670 dimerization interface [polypeptide binding]; other site 243090005671 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243090005672 catalytic residues [active] 243090005673 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 243090005674 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243090005675 FAD binding domain; Region: FAD_binding_4; pfam01565 243090005676 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 243090005677 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243090005678 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 243090005679 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 243090005680 MoaE interaction surface [polypeptide binding]; other site 243090005681 MoeB interaction surface [polypeptide binding]; other site 243090005682 thiocarboxylated glycine; other site 243090005683 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 243090005684 MoaE homodimer interface [polypeptide binding]; other site 243090005685 MoaD interaction [polypeptide binding]; other site 243090005686 active site residues [active] 243090005687 FliW protein; Region: FliW; pfam02623 243090005688 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 243090005689 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 243090005690 tellurium resistance terB-like protein; Region: terB_like; cd07177 243090005691 metal binding site [ion binding]; metal-binding site 243090005692 Domain of unknown function (DUF202); Region: DUF202; pfam02656 243090005693 cosmid pircos-d2d04/ cosmid gap joining point 243090005694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090005695 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 243090005696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090005697 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243090005698 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 243090005699 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 243090005700 active site 243090005701 catalytic triad [active] 243090005702 dimer interface [polypeptide binding]; other site 243090005703 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 243090005704 putative active site [active] 243090005705 ribonuclease PH; Reviewed; Region: rph; PRK00173 243090005706 Ribonuclease PH; Region: RNase_PH_bact; cd11362 243090005707 hexamer interface [polypeptide binding]; other site 243090005708 active site 243090005709 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090005710 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090005711 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 243090005712 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 243090005713 Ligand Binding Site [chemical binding]; other site 243090005714 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090005715 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090005716 active site 243090005717 ATP binding site [chemical binding]; other site 243090005718 substrate binding site [chemical binding]; other site 243090005719 activation loop (A-loop); other site 243090005720 GAF domain; Region: GAF; pfam01590 243090005721 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 243090005722 metal binding site [ion binding]; metal-binding site 243090005723 nucleotidyl binding site; other site 243090005724 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 243090005725 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 243090005726 substrate-cofactor binding pocket; other site 243090005727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090005728 homodimer interface [polypeptide binding]; other site 243090005729 Aminotransferase class IV; Region: Aminotran_4; pfam01063 243090005730 catalytic residue [active] 243090005731 Fatty acid desaturase; Region: FA_desaturase; pfam00487 243090005732 HI0933-like protein; Region: HI0933_like; pfam03486 243090005733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090005734 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 243090005735 cyclase homology domain; Region: CHD; cd07302 243090005736 nucleotidyl binding site; other site 243090005737 metal binding site [ion binding]; metal-binding site 243090005738 dimer interface [polypeptide binding]; other site 243090005739 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 243090005740 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 243090005741 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 243090005742 active site 243090005743 HIGH motif; other site 243090005744 KMSK motif region; other site 243090005745 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 243090005746 tRNA binding surface [nucleotide binding]; other site 243090005747 anticodon binding site; other site 243090005748 Oligomerization domain; Region: Oligomerization; pfam02410 243090005749 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 243090005750 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 243090005751 catalytic triad [active] 243090005752 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 243090005753 nucleotide binding site [chemical binding]; other site 243090005754 putative NEF/HSP70 interaction site [polypeptide binding]; other site 243090005755 SBD interface [polypeptide binding]; other site 243090005756 cosmid gap/ cosmid pircos-c1d11 joining point 243090005757 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 243090005758 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 243090005759 nucleotide binding site [chemical binding]; other site 243090005760 putative NEF/HSP70 interaction site [polypeptide binding]; other site 243090005761 SBD interface [polypeptide binding]; other site 243090005762 DNA-K related protein; Region: DUF3731; pfam12531 243090005763 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 243090005764 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 243090005765 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 243090005766 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243090005767 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 243090005768 homodimer interface [polypeptide binding]; other site 243090005769 metal binding site [ion binding]; metal-binding site 243090005770 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090005771 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090005772 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090005773 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090005774 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090005775 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 243090005776 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243090005777 hypothetical protein; Provisional; Region: PRK11281 243090005778 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090005779 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 243090005780 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243090005781 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 243090005782 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 243090005783 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090005784 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090005785 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 243090005786 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl19058 243090005787 active site 243090005788 Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123 243090005789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090005790 active site 243090005791 phosphorylation site [posttranslational modification] 243090005792 intermolecular recognition site; other site 243090005793 dimerization interface [polypeptide binding]; other site 243090005794 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243090005795 catalytic residues [active] 243090005796 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090005797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090005798 TPR motif; other site 243090005799 TPR repeat; Region: TPR_11; pfam13414 243090005800 binding surface 243090005801 TPR repeat; Region: TPR_11; pfam13414 243090005802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090005803 binding surface 243090005804 TPR motif; other site 243090005805 TPR repeat; Region: TPR_11; pfam13414 243090005806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090005807 binding surface 243090005808 TPR motif; other site 243090005809 TPR repeat; Region: TPR_11; pfam13414 243090005810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090005811 binding surface 243090005812 TPR motif; other site 243090005813 YTV; Region: YTV; pfam07639 243090005814 Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970 243090005815 Helix-turn-helix domain; Region: HTH_17; pfam12728 243090005816 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 243090005817 active site 243090005818 phosphorylation site [posttranslational modification] 243090005819 large tegument protein UL36; Provisional; Region: PHA03247 243090005820 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 243090005821 16S/18S rRNA binding site [nucleotide binding]; other site 243090005822 S13e-L30e interaction site [polypeptide binding]; other site 243090005823 25S rRNA binding site [nucleotide binding]; other site 243090005824 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 243090005825 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 243090005826 RNase E interface [polypeptide binding]; other site 243090005827 trimer interface [polypeptide binding]; other site 243090005828 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 243090005829 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 243090005830 RNase E interface [polypeptide binding]; other site 243090005831 trimer interface [polypeptide binding]; other site 243090005832 active site 243090005833 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 243090005834 putative nucleic acid binding region [nucleotide binding]; other site 243090005835 G-X-X-G motif; other site 243090005836 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 243090005837 RNA binding site [nucleotide binding]; other site 243090005838 domain interface; other site 243090005839 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090005840 Cytochrome c; Region: Cytochrom_C; cl11414 243090005841 cosmid pircos-c1d11/ cosmid pircos-a1g04 joining point 243090005842 Alpha conotoxin precursor; Region: Toxin_8; pfam07365 243090005843 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 243090005844 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 243090005845 putative active site [active] 243090005846 putative metal binding site [ion binding]; other site 243090005847 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243090005848 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 243090005849 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 243090005850 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243090005851 active site 243090005852 catalytic tetrad [active] 243090005853 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 243090005854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243090005855 putative substrate translocation pore; other site 243090005856 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 243090005857 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 243090005858 GTP/Mg2+ binding site [chemical binding]; other site 243090005859 G4 box; other site 243090005860 G5 box; other site 243090005861 G1 box; other site 243090005862 Switch I region; other site 243090005863 G2 box; other site 243090005864 G3 box; other site 243090005865 Switch II region; other site 243090005866 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 243090005867 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090005868 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 243090005869 Protein of unknown function (DUF805); Region: DUF805; cl01224 243090005870 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 243090005871 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 243090005872 putative active site [active] 243090005873 catalytic site [active] 243090005874 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 243090005875 putative active site [active] 243090005876 catalytic site [active] 243090005877 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 243090005878 active site 243090005879 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 243090005880 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 243090005881 Catalytic site [active] 243090005882 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 243090005883 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243090005884 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 243090005885 active site 243090005886 metal binding site [ion binding]; metal-binding site 243090005887 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090005888 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243090005889 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 243090005890 Ligand binding site; other site 243090005891 Putative Catalytic site; other site 243090005892 DXD motif; other site 243090005893 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243090005894 active site 243090005895 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 243090005896 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243090005897 phosphopeptide binding site; other site 243090005898 Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340 243090005899 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 243090005900 catalytic Zn binding site [ion binding]; other site 243090005901 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 243090005902 structural Zn binding site [ion binding]; other site 243090005903 tetramer interface [polypeptide binding]; other site 243090005904 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 243090005905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243090005906 non-specific DNA binding site [nucleotide binding]; other site 243090005907 salt bridge; other site 243090005908 sequence-specific DNA binding site [nucleotide binding]; other site 243090005909 Cupin domain; Region: Cupin_2; pfam07883 243090005910 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 243090005911 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090005912 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090005913 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 243090005914 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 243090005915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243090005916 motif II; other site 243090005917 DDE superfamily endonuclease; Region: DDE_5; pfam13546 243090005918 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 243090005919 putative catalytic residues [active] 243090005920 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243090005921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090005922 Walker A motif; other site 243090005923 ATP binding site [chemical binding]; other site 243090005924 Walker B motif; other site 243090005925 arginine finger; other site 243090005926 cosmid pircos-a1g04/ cosmid pircos-a3e11 joining point 243090005927 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 243090005928 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090005929 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090005930 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 243090005931 active site 243090005932 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243090005933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243090005934 salt bridge; other site 243090005935 non-specific DNA binding site [nucleotide binding]; other site 243090005936 sequence-specific DNA binding site [nucleotide binding]; other site 243090005937 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 243090005938 ParB-like nuclease domain; Region: ParB; smart00470 243090005939 putative transposase OrfB; Reviewed; Region: PHA02517 243090005940 HTH-like domain; Region: HTH_21; pfam13276 243090005941 Integrase core domain; Region: rve; pfam00665 243090005942 Integrase core domain; Region: rve_3; pfam13683 243090005943 Transposase; Region: HTH_Tnp_1; cl17663 243090005944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 243090005945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243090005946 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243090005947 Domain of unknown function (DUF3508); Region: DUF3508; pfam12018 243090005948 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090005949 metal ion-dependent adhesion site (MIDAS); other site 243090005950 putative protein phosphatase; Region: PHA02239 243090005951 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 243090005952 active site 243090005953 metal binding site [ion binding]; metal-binding site 243090005954 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 243090005955 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 243090005956 Type II transport protein GspH; Region: GspH; pfam12019 243090005957 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 243090005958 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 243090005959 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 243090005960 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090005961 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090005962 structural tetrad; other site 243090005963 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090005964 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 243090005965 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090005966 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090005967 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 243090005968 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 243090005969 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090005970 Protein of unknown function DUF116; Region: DUF116; pfam01976 243090005971 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 243090005972 substrate binding pocket [chemical binding]; other site 243090005973 substrate-Mg2+ binding site; other site 243090005974 aspartate-rich region 1; other site 243090005975 aspartate-rich region 2; other site 243090005976 squalene/oxidosqualene cyclases; Region: squalene_cyclas; TIGR01787 243090005977 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 243090005978 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 243090005979 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 243090005980 ATP binding site [chemical binding]; other site 243090005981 Walker A motif; other site 243090005982 hexamer interface [polypeptide binding]; other site 243090005983 Walker B motif; other site 243090005984 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 243090005985 cosmid pircos-a3e11/ cosmid pircos-d2d03 joining point 243090005986 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 243090005987 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090005988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090005989 active site 243090005990 phosphorylation site [posttranslational modification] 243090005991 intermolecular recognition site; other site 243090005992 dimerization interface [polypeptide binding]; other site 243090005993 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090005994 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243090005995 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 243090005996 putative NAD(P) binding site [chemical binding]; other site 243090005997 catalytic Zn binding site [ion binding]; other site 243090005998 Putative peptidase family; Region: Metallopep; pfam12044 243090005999 Modifier of rudimentary (Mod(r)) protein; Region: Mod_r; pfam07200 243090006000 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 243090006001 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 243090006002 trimer interface [polypeptide binding]; other site 243090006003 putative metal binding site [ion binding]; other site 243090006004 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 243090006005 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243090006006 Zn2+ binding site [ion binding]; other site 243090006007 Mg2+ binding site [ion binding]; other site 243090006008 PAS domain; Region: PAS; smart00091 243090006009 PAS domain; Region: PAS_9; pfam13426 243090006010 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243090006011 metal binding site [ion binding]; metal-binding site 243090006012 active site 243090006013 I-site; other site 243090006014 MAPEG family; Region: MAPEG; cl09190 243090006015 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090006016 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090006017 DNA binding residues [nucleotide binding] 243090006018 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 243090006019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090006020 ATP binding site [chemical binding]; other site 243090006021 putative Mg++ binding site [ion binding]; other site 243090006022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090006023 nucleotide binding region [chemical binding]; other site 243090006024 ATP-binding site [chemical binding]; other site 243090006025 RQC domain; Region: RQC; pfam09382 243090006026 HRDC domain; Region: HRDC; pfam00570 243090006027 Helix-turn-helix domain; Region: HTH_40; pfam14493 243090006028 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 243090006029 TM-ABC transporter signature motif; other site 243090006030 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 243090006031 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 243090006032 Walker A/P-loop; other site 243090006033 ATP binding site [chemical binding]; other site 243090006034 Q-loop/lid; other site 243090006035 ABC transporter signature motif; other site 243090006036 Walker B; other site 243090006037 D-loop; other site 243090006038 H-loop/switch region; other site 243090006039 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 243090006040 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 243090006041 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 243090006042 ligand binding site [chemical binding]; other site 243090006043 TLC ATP/ADP transporter; Region: TLC; cl03940 243090006044 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 243090006045 feedback inhibition sensing region; other site 243090006046 homohexameric interface [polypeptide binding]; other site 243090006047 nucleotide binding site [chemical binding]; other site 243090006048 N-acetyl-L-glutamate binding site [chemical binding]; other site 243090006049 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 243090006050 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243090006051 catalytic residue [active] 243090006052 ornithine carbamoyltransferase; Provisional; Region: PRK00779 243090006053 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 243090006054 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 243090006055 DNA translocase FtsK; Provisional; Region: PRK10263 243090006056 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090006057 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 243090006058 putative ADP-binding pocket [chemical binding]; other site 243090006059 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 243090006060 active site flap/lid [active] 243090006061 nucleophilic elbow; other site 243090006062 catalytic triad [active] 243090006063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 243090006064 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 243090006065 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 243090006066 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 243090006067 active site 243090006068 Int/Topo IB signature motif; other site 243090006069 cosmid pircos-d2d03/ cosmid pircos-b1f05 joining point 243090006070 DDE superfamily endonuclease; Region: DDE_5; pfam13546 243090006071 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 243090006072 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090006073 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090006074 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090006075 60S ribosomal protein L12; Provisional; Region: PTZ00105 243090006076 Protein kinase domain; Region: Pkinase; pfam00069 243090006077 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090006078 active site 243090006079 ATP binding site [chemical binding]; other site 243090006080 substrate binding site [chemical binding]; other site 243090006081 activation loop (A-loop); other site 243090006082 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090006083 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090006084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090006085 binding surface 243090006086 TPR motif; other site 243090006087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090006088 binding surface 243090006089 TPR motif; other site 243090006090 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090006091 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 243090006092 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090006093 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090006094 DNA binding residues [nucleotide binding] 243090006095 Domain of unknown function DUF21; Region: DUF21; pfam01595 243090006096 Domain of unknown function DUF21; Region: DUF21; pfam01595 243090006097 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 243090006098 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 243090006099 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 243090006100 Transporter associated domain; Region: CorC_HlyC; smart01091 243090006101 Acyltransferase family; Region: Acyl_transf_3; cl19154 243090006102 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 243090006103 ligand-binding site [chemical binding]; other site 243090006104 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090006105 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090006106 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090006107 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090006108 cosmid pircos-b1f05/ cosmid pircos-d3f08 joining point 243090006109 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090006110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090006111 Walker A motif; other site 243090006112 ATP binding site [chemical binding]; other site 243090006113 Walker B motif; other site 243090006114 arginine finger; other site 243090006115 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090006116 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090006117 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 243090006118 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 243090006119 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 243090006120 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 243090006121 active site 243090006122 substrate binding site [chemical binding]; other site 243090006123 metal binding site [ion binding]; metal-binding site 243090006124 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 243090006125 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 243090006126 oligomer interface [polypeptide binding]; other site 243090006127 metal binding site [ion binding]; metal-binding site 243090006128 metal binding site [ion binding]; metal-binding site 243090006129 Cl binding site [ion binding]; other site 243090006130 aspartate ring; other site 243090006131 basic sphincter; other site 243090006132 putative hydrophobic gate; other site 243090006133 periplasmic entrance; other site 243090006134 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 243090006135 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 243090006136 Walker A/P-loop; other site 243090006137 ATP binding site [chemical binding]; other site 243090006138 Q-loop/lid; other site 243090006139 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 243090006140 DNA packaging tegument protein UL25; Provisional; Region: PHA03252 243090006141 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 243090006142 ABC transporter signature motif; other site 243090006143 Walker B; other site 243090006144 D-loop; other site 243090006145 H-loop/switch region; other site 243090006146 Protein of unknown function (DUF456); Region: DUF456; pfam04306 243090006147 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243090006148 active site 243090006149 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 243090006150 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243090006151 RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959 243090006152 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090006153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090006154 DNA binding residues [nucleotide binding] 243090006155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 243090006156 phosphorylation site [posttranslational modification] 243090006157 intermolecular recognition site; other site 243090006158 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 243090006159 tetramerization interface [polypeptide binding]; other site 243090006160 active site 243090006161 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 243090006162 Peptidase family M50; Region: Peptidase_M50; pfam02163 243090006163 active site 243090006164 putative substrate binding region [chemical binding]; other site 243090006165 Glucuronate isomerase; Region: UxaC; cl00829 243090006166 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090006167 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090006168 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090006169 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 243090006170 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 243090006171 protein-splicing catalytic site; other site 243090006172 thioester formation/cholesterol transfer; other site 243090006173 Pretoxin HINT domain; Region: PT-HINT; pfam07591 243090006174 CHAT domain; Region: CHAT; cl19248 243090006175 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 243090006176 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243090006177 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243090006178 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 243090006179 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243090006180 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243090006181 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 243090006182 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 243090006183 PA/protease or protease-like domain interface [polypeptide binding]; other site 243090006184 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 243090006185 metal binding site [ion binding]; metal-binding site 243090006186 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 243090006187 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090006188 cosmid pircos-d3f08/ cosmid pircos-b2a11 joining point 243090006189 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 243090006190 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 243090006191 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 243090006192 catalytic motif [active] 243090006193 Zn binding site [ion binding]; other site 243090006194 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 243090006195 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090006196 metal ion-dependent adhesion site (MIDAS); other site 243090006197 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 243090006198 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 243090006199 NAD binding site [chemical binding]; other site 243090006200 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243090006201 AIR carboxylase; Region: AIRC; pfam00731 243090006202 GrpB protein; Region: GrpB; pfam04229 243090006203 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243090006204 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 243090006205 active site 243090006206 catalytic tetrad [active] 243090006207 Putative esterase; Region: Esterase; pfam00756 243090006208 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 243090006209 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 243090006210 active site 243090006211 metal binding site [ion binding]; metal-binding site 243090006212 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243090006213 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 243090006214 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 243090006215 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 243090006216 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 243090006217 Int/Topo IB signature motif; other site 243090006218 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 243090006219 Putative transposase; Region: Y2_Tnp; pfam04986 243090006220 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 243090006221 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243090006222 active site 243090006223 DNA binding site [nucleotide binding] 243090006224 Int/Topo IB signature motif; other site 243090006225 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 243090006226 Na binding site [ion binding]; other site 243090006227 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 243090006228 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 243090006229 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090006230 HEAT repeats; Region: HEAT_2; pfam13646 243090006231 HEAT repeats; Region: HEAT_2; pfam13646 243090006232 Cytochrome c; Region: Cytochrom_C; cl11414 243090006233 cosmid pircos-b2a11/ cosmid pircos-b2d05 joining point 243090006234 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 243090006235 active site 243090006236 catalytic triad [active] 243090006237 oxyanion hole [active] 243090006238 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090006239 Sulfatase; Region: Sulfatase; cl19157 243090006240 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090006241 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090006242 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 243090006243 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 243090006244 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 243090006245 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 243090006246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090006247 ATP binding site [chemical binding]; other site 243090006248 putative Mg++ binding site [ion binding]; other site 243090006249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090006250 nucleotide binding region [chemical binding]; other site 243090006251 ATP-binding site [chemical binding]; other site 243090006252 TRCF domain; Region: TRCF; pfam03461 243090006253 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090006254 Trp docking motif [polypeptide binding]; other site 243090006255 PQQ-like domain; Region: PQQ_2; pfam13360 243090006256 active site 243090006257 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 243090006258 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 243090006259 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 243090006260 nucleotide binding site [chemical binding]; other site 243090006261 substrate binding site [chemical binding]; other site 243090006262 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090006263 TPR repeat; Region: TPR_11; pfam13414 243090006264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090006265 binding surface 243090006266 TPR motif; other site 243090006267 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 243090006268 dimer interface [polypeptide binding]; other site 243090006269 active site 243090006270 glycine-pyridoxal phosphate binding site [chemical binding]; other site 243090006271 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 243090006272 folate binding site [chemical binding]; other site 243090006273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090006274 active site 243090006275 phosphorylation site [posttranslational modification] 243090006276 intermolecular recognition site; other site 243090006277 dimerization interface [polypeptide binding]; other site 243090006278 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 243090006279 active site 243090006280 epoxyqueuosine reductase; Region: TIGR00276 243090006281 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 243090006282 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 243090006283 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 243090006284 FOG: CBS domain [General function prediction only]; Region: COG0517 243090006285 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 243090006286 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 243090006287 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 243090006288 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243090006289 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243090006290 Walker A/P-loop; other site 243090006291 ATP binding site [chemical binding]; other site 243090006292 Q-loop/lid; other site 243090006293 ABC transporter signature motif; other site 243090006294 Walker B; other site 243090006295 D-loop; other site 243090006296 H-loop/switch region; other site 243090006297 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 243090006298 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243090006299 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 243090006300 Domain of unknown function DUF21; Region: DUF21; pfam01595 243090006301 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243090006302 classical (c) SDRs; Region: SDR_c; cd05233 243090006303 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 243090006304 NAD(P) binding site [chemical binding]; other site 243090006305 active site 243090006306 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090006307 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090006308 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 243090006309 O-Antigen ligase; Region: Wzy_C; pfam04932 243090006310 cosmid pircos-b2d05/ cosmid pircos-a3c11 joining point 243090006311 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 243090006312 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243090006313 catalytic residue [active] 243090006314 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 243090006315 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 243090006316 ligand binding site [chemical binding]; other site 243090006317 NAD binding site [chemical binding]; other site 243090006318 dimerization interface [polypeptide binding]; other site 243090006319 catalytic site [active] 243090006320 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 243090006321 putative L-serine binding site [chemical binding]; other site 243090006322 Protein of unknown function (DUF3295); Region: DUF3295; pfam11702 243090006323 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 243090006324 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 243090006325 Substrate binding site; other site 243090006326 Cupin domain; Region: Cupin_2; cl17218 243090006327 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090006328 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243090006329 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243090006330 heme-binding residues [chemical binding]; other site 243090006331 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243090006332 heme-binding residues [chemical binding]; other site 243090006333 Cytochrome c7; Region: Cytochrome_C7; cl19206 243090006334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090006335 TPR motif; other site 243090006336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090006337 TPR motif; other site 243090006338 binding surface 243090006339 EspA-like secreted protein; Region: EspA; cl04069 243090006340 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243090006341 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 243090006342 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 243090006343 NAD binding site [chemical binding]; other site 243090006344 homodimer interface [polypeptide binding]; other site 243090006345 active site 243090006346 substrate binding site [chemical binding]; other site 243090006347 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 243090006348 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 243090006349 active site 243090006350 Int/Topo IB signature motif; other site 243090006351 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 243090006352 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 243090006353 dimer interface [polypeptide binding]; other site 243090006354 active site 243090006355 CoA binding pocket [chemical binding]; other site 243090006356 DNA-binding proteins similar to HU domains; Region: HU_like; cd13834 243090006357 putative DNA binding site [nucleotide binding]; other site 243090006358 putative dimer interface [polypeptide binding]; other site 243090006359 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090006360 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 243090006361 active site 243090006362 VCBS repeat; Region: VCBS_repeat; TIGR01965 243090006363 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 243090006364 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 243090006365 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 243090006366 homotetramer interface [polypeptide binding]; other site 243090006367 ligand binding site [chemical binding]; other site 243090006368 catalytic site [active] 243090006369 NAD binding site [chemical binding]; other site 243090006370 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090006371 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090006372 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090006373 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090006374 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243090006375 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243090006376 hypothetical protein; Provisional; Region: PRK13665 243090006377 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 243090006378 active site 243090006379 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 243090006380 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 243090006381 glutamine binding [chemical binding]; other site 243090006382 catalytic triad [active] 243090006383 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 243090006384 dimer interface [polypeptide binding]; other site 243090006385 ADP-ribose binding site [chemical binding]; other site 243090006386 active site 243090006387 nudix motif; other site 243090006388 metal binding site [ion binding]; metal-binding site 243090006389 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 243090006390 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 243090006391 Ligand binding site; other site 243090006392 Putative Catalytic site; other site 243090006393 DXD motif; other site 243090006394 Protein of unknown function; Region: DUF3971; pfam13116 243090006395 Protein of unknown function; Region: DUF3971; pfam13116 243090006396 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 243090006397 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243090006398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 243090006399 active site 243090006400 phosphorylation site [posttranslational modification] 243090006401 intermolecular recognition site; other site 243090006402 dimerization interface [polypeptide binding]; other site 243090006403 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243090006404 DNA binding residues [nucleotide binding] 243090006405 dimerization interface [polypeptide binding]; other site 243090006406 cosmid pircos-a3c11/ cosmid pircos-c4c11 joining point 243090006407 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 243090006408 classical (c) SDRs; Region: SDR_c; cd05233 243090006409 NAD(P) binding site [chemical binding]; other site 243090006410 active site 243090006411 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 243090006412 putative active site [active] 243090006413 putative metal binding residues [ion binding]; other site 243090006414 signature motif; other site 243090006415 putative triphosphate binding site [ion binding]; other site 243090006416 dimer interface [polypeptide binding]; other site 243090006417 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 243090006418 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 243090006419 thiamine phosphate binding site [chemical binding]; other site 243090006420 active site 243090006421 pyrophosphate binding site [ion binding]; other site 243090006422 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 243090006423 active site 243090006424 catalytic triad [active] 243090006425 oxyanion hole [active] 243090006426 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 243090006427 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243090006428 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243090006429 CHC2 zinc finger; Region: zf-CHC2; cl17510 243090006430 DNA primase, catalytic core; Region: dnaG; TIGR01391 243090006431 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 243090006432 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 243090006433 active site 243090006434 metal binding site [ion binding]; metal-binding site 243090006435 interdomain interaction site; other site 243090006436 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 243090006437 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 243090006438 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 243090006439 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090006440 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243090006441 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090006442 DNA binding residues [nucleotide binding] 243090006443 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 243090006444 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 243090006445 Low-spin heme binding site [chemical binding]; other site 243090006446 Putative water exit pathway; other site 243090006447 Binuclear center (active site) [active] 243090006448 Putative proton exit pathway; other site 243090006449 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 243090006450 N-terminal domain of cytochrome oxidase-cbb3, FixP; Region: FixP_N; pfam14715 243090006451 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 243090006452 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 243090006453 4Fe-4S binding domain; Region: Fer4_5; pfam12801 243090006454 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 243090006455 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 243090006456 FixH; Region: FixH; pfam05751 243090006457 Cytochrome C biogenesis protein transmembrane region; Region: DsbD_2; pfam13386 243090006458 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 243090006459 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 243090006460 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243090006461 metal-binding site [ion binding] 243090006462 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243090006463 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 243090006464 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 243090006465 Putative serine esterase (DUF676); Region: DUF676; pfam05057 243090006466 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243090006467 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243090006468 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 243090006469 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243090006470 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 243090006471 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 243090006472 trmE is a tRNA modification GTPase; Region: trmE; cd04164 243090006473 G1 box; other site 243090006474 GTP/Mg2+ binding site [chemical binding]; other site 243090006475 Switch I region; other site 243090006476 G2 box; other site 243090006477 Switch II region; other site 243090006478 G3 box; other site 243090006479 G4 box; other site 243090006480 G5 box; other site 243090006481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090006482 S-adenosylmethionine binding site [chemical binding]; other site 243090006483 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 243090006484 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 243090006485 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 243090006486 Ligand binding site; other site 243090006487 DXD motif; other site 243090006488 Tetrahydromethanopterin S-methyltransferase, subunit E; Region: MtrE; cl01675 243090006489 Putative glucoamylase; Region: Glycoamylase; cl19893 243090006490 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 243090006491 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 243090006492 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243090006493 catalytic residues [active] 243090006494 cosmid pircos-c4c11/ cosmid pircos-a1d03 joining point 243090006495 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090006496 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090006497 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 243090006498 SigmaW regulon antibacterial; Region: YdfA_immunity; pfam12127 243090006499 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 243090006500 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 243090006501 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 243090006502 dimerization interface [polypeptide binding]; other site 243090006503 ligand binding site [chemical binding]; other site 243090006504 NADP binding site [chemical binding]; other site 243090006505 catalytic site [active] 243090006506 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243090006507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090006508 TPR motif; other site 243090006509 binding surface 243090006510 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243090006511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090006512 binding surface 243090006513 TPR motif; other site 243090006514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090006515 binding surface 243090006516 TPR motif; other site 243090006517 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090006518 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090006519 binding surface 243090006520 TPR motif; other site 243090006521 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090006522 Trp docking motif [polypeptide binding]; other site 243090006523 active site 243090006524 PQQ-like domain; Region: PQQ_2; pfam13360 243090006525 PAS fold; Region: PAS_4; pfam08448 243090006526 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090006527 putative active site [active] 243090006528 heme pocket [chemical binding]; other site 243090006529 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243090006530 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243090006531 DNA binding residues [nucleotide binding] 243090006532 dimerization interface [polypeptide binding]; other site 243090006533 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 243090006534 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 243090006535 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 243090006536 RNA binding site [nucleotide binding]; other site 243090006537 active site 243090006538 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 243090006539 Ferredoxin [Energy production and conversion]; Region: COG1146 243090006540 4Fe-4S binding domain; Region: Fer4; pfam00037 243090006541 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 243090006542 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 243090006543 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 243090006544 putative RNA binding site [nucleotide binding]; other site 243090006545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090006546 S-adenosylmethionine binding site [chemical binding]; other site 243090006547 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243090006548 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243090006549 phosphopeptide binding site; other site 243090006550 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 243090006551 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 243090006552 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 243090006553 Fasciclin domain; Region: Fasciclin; pfam02469 243090006554 Protein of unknown function (DUF1682); Region: DUF1682; pfam07946 243090006555 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090006556 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090006557 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090006558 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090006559 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090006560 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090006561 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090006562 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090006563 cosmid pircos-a1d03/ cosmid pircos-d3b02 joining point 243090006564 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 243090006565 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 243090006566 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 243090006567 active site 243090006568 HIGH motif; other site 243090006569 dimer interface [polypeptide binding]; other site 243090006570 KMSKS motif; other site 243090006571 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243090006572 homodimer interface [polypeptide binding]; other site 243090006573 substrate-cofactor binding pocket; other site 243090006574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090006575 catalytic residue [active] 243090006576 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243090006577 homodimer interface [polypeptide binding]; other site 243090006578 substrate-cofactor binding pocket; other site 243090006579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090006580 catalytic residue [active] 243090006581 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243090006582 Protein of unknown function DUF58; Region: DUF58; pfam01882 243090006583 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243090006584 metal ion-dependent adhesion site (MIDAS); other site 243090006585 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 243090006586 CARDB; Region: CARDB; pfam07705 243090006587 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090006588 metal ion-dependent adhesion site (MIDAS); other site 243090006589 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 243090006590 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 243090006591 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090006592 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090006593 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 243090006594 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090006595 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090006596 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090006597 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090006598 Domain of unknown function (DUF4465); Region: DUF4465; pfam14717 243090006599 Domain of unknown function (DUF4465); Region: DUF4465; pfam14717 243090006600 Domain of unknown function (DUF4465); Region: DUF4465; pfam14717 243090006601 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090006602 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090006603 extended (e) SDRs; Region: SDR_e; cd08946 243090006604 NAD(P) binding site [chemical binding]; other site 243090006605 active site 243090006606 substrate binding site [chemical binding]; other site 243090006607 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 243090006608 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 243090006609 G1 box; other site 243090006610 putative GEF interaction site [polypeptide binding]; other site 243090006611 GTP/Mg2+ binding site [chemical binding]; other site 243090006612 Switch I region; other site 243090006613 G2 box; other site 243090006614 G3 box; other site 243090006615 Switch II region; other site 243090006616 G4 box; other site 243090006617 G5 box; other site 243090006618 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 243090006619 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 243090006620 phosphoglycerate mutase; Provisional; Region: PTZ00122 243090006621 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243090006622 catalytic core [active] 243090006623 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 243090006624 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 243090006625 Walker A/P-loop; other site 243090006626 ATP binding site [chemical binding]; other site 243090006627 Q-loop/lid; other site 243090006628 ABC transporter signature motif; other site 243090006629 Walker B; other site 243090006630 D-loop; other site 243090006631 H-loop/switch region; other site 243090006632 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 243090006633 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 243090006634 CAAX protease self-immunity; Region: Abi; pfam02517 243090006635 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 243090006636 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 243090006637 Mg++ binding site [ion binding]; other site 243090006638 putative catalytic motif [active] 243090006639 substrate binding site [chemical binding]; other site 243090006640 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 243090006641 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243090006642 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 243090006643 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243090006644 active site 243090006645 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 243090006646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090006647 ATP binding site [chemical binding]; other site 243090006648 putative Mg++ binding site [ion binding]; other site 243090006649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090006650 nucleotide binding region [chemical binding]; other site 243090006651 ATP-binding site [chemical binding]; other site 243090006652 cosmid pircos-d3b02/ cosmid pircos-c4a09 joining point 243090006653 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 243090006654 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 243090006655 substrate binding pocket [chemical binding]; other site 243090006656 dimer interface [polypeptide binding]; other site 243090006657 inhibitor binding site; inhibition site 243090006658 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 243090006659 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090006660 FeS/SAM binding site; other site 243090006661 HemN C-terminal domain; Region: HemN_C; pfam06969 243090006662 PQQ-like domain; Region: PQQ_2; pfam13360 243090006663 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090006664 Trp docking motif [polypeptide binding]; other site 243090006665 active site 243090006666 PQQ-like domain; Region: PQQ_2; pfam13360 243090006667 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase; Region: PLN02520 243090006668 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 243090006669 active site 243090006670 catalytic residue [active] 243090006671 dimer interface [polypeptide binding]; other site 243090006672 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 243090006673 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 243090006674 shikimate binding site; other site 243090006675 NAD(P) binding site [chemical binding]; other site 243090006676 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821 243090006677 dimer interface [polypeptide binding]; other site 243090006678 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 243090006679 active site 243090006680 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243090006681 substrate binding site [chemical binding]; other site 243090006682 catalytic residue [active] 243090006683 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 243090006684 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090006685 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090006686 protein binding site [polypeptide binding]; other site 243090006687 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 243090006688 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 243090006689 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 243090006690 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 243090006691 recombination protein RecR; Reviewed; Region: recR; PRK00076 243090006692 RecR protein; Region: RecR; pfam02132 243090006693 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 243090006694 putative active site [active] 243090006695 putative metal-binding site [ion binding]; other site 243090006696 tetramer interface [polypeptide binding]; other site 243090006697 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 243090006698 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 243090006699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090006700 Walker A motif; other site 243090006701 ATP binding site [chemical binding]; other site 243090006702 Walker B motif; other site 243090006703 arginine finger; other site 243090006704 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 243090006705 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 243090006706 Predicted permeases [General function prediction only]; Region: RarD; COG2962 243090006707 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 243090006708 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243090006709 active site 243090006710 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243090006711 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 243090006712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243090006713 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 243090006714 Enoylreductase; Region: PKS_ER; smart00829 243090006715 NAD(P) binding site [chemical binding]; other site 243090006716 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 243090006717 putative NADP binding site [chemical binding]; other site 243090006718 short chain dehydrogenase; Region: adh_short; pfam00106 243090006719 active site 243090006720 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243090006721 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 243090006722 Condensation domain; Region: Condensation; pfam00668 243090006723 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243090006724 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243090006725 acyl-activating enzyme (AAE) consensus motif; other site 243090006726 AMP binding site [chemical binding]; other site 243090006727 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243090006728 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 243090006729 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243090006730 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 243090006731 FtsX-like permease family; Region: FtsX; pfam02687 243090006732 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243090006733 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090006734 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243090006735 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090006736 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090006737 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 243090006738 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 243090006739 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090006740 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 243090006741 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090006742 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090006743 intermolecular salt bridges; other site 243090006744 calcium mediated ligand binding site; other site 243090006745 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090006746 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 243090006747 putative ADP-binding pocket [chemical binding]; other site 243090006748 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090006749 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090006750 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243090006751 active site 243090006752 Protein of unknown function, DUF480; Region: DUF480; pfam04337 243090006753 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243090006754 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 243090006755 putative acyl-acceptor binding pocket; other site 243090006756 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 243090006757 acyl-activating enzyme (AAE) consensus motif; other site 243090006758 putative AMP binding site [chemical binding]; other site 243090006759 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 243090006760 active site 243090006761 catalytic residues [active] 243090006762 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 243090006763 Na binding site [ion binding]; other site 243090006764 cosmid pircos-c4a09/ cosmid pircos-c2g02 joining point 243090006765 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 243090006766 putative dimerization interface [polypeptide binding]; other site 243090006767 putative ligand binding site [chemical binding]; other site 243090006768 Transcriptional regulators [Transcription]; Region: PurR; COG1609 243090006769 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243090006770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090006771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090006772 peptide chain release factor 2; Provisional; Region: PRK05589 243090006773 PCRF domain; Region: PCRF; pfam03462 243090006774 RF-1 domain; Region: RF-1; pfam00472 243090006775 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 243090006776 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 243090006777 Ligand Binding Site [chemical binding]; other site 243090006778 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090006779 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090006780 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090006781 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090006782 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 243090006783 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 243090006784 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 243090006785 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090006786 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090006787 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090006788 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090006789 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090006790 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090006791 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 243090006792 HEAT repeats; Region: HEAT_2; pfam13646 243090006793 large tegument protein UL36; Provisional; Region: PHA03247 243090006794 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 243090006795 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 243090006796 purine nucleoside phosphorylase; Provisional; Region: PRK08202 243090006797 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 243090006798 Domain of unknown function DUF87; Region: DUF87; cl19135 243090006799 AAA-like domain; Region: AAA_10; pfam12846 243090006800 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 243090006801 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090006802 Sulfatase; Region: Sulfatase; pfam00884 243090006803 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090006804 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090006805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090006806 Walker A motif; other site 243090006807 ATP binding site [chemical binding]; other site 243090006808 Walker B motif; other site 243090006809 arginine finger; other site 243090006810 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 243090006811 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090006812 Putative zinc ribbon domain; Region: DUF164; pfam02591 243090006813 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 243090006814 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 243090006815 CoA-binding site [chemical binding]; other site 243090006816 ATP-binding [chemical binding]; other site 243090006817 cosmid pircos-c2g02/ cosmid pircos-a3e04 joining point 243090006818 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090006819 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 243090006820 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 243090006821 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 243090006822 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 243090006823 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 243090006824 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 243090006825 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 243090006826 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 243090006827 dimerization interface [polypeptide binding]; other site 243090006828 active site 243090006829 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 243090006830 CoA-binding domain; Region: CoA_binding_3; pfam13727 243090006831 Bacterial sugar transferase; Region: Bac_transf; pfam02397 243090006832 YacP-like NYN domain; Region: NYN_YacP; cl01491 243090006833 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 243090006834 Domain of unknown function (DUF243); Region: DUF243; cl11612 243090006835 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090006836 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090006837 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090006838 DDE superfamily endonuclease; Region: DDE_5; pfam13546 243090006839 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 243090006840 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090006841 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090006842 DNA binding residues [nucleotide binding] 243090006843 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 243090006844 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090006845 activation loop (A-loop); other site 243090006846 Histone H1-like nucleoprotein HC2; Region: HC2; cl19298 243090006847 glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095 243090006848 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 243090006849 ADP-binding pocket [chemical binding]; other site 243090006850 homodimer interface [polypeptide binding]; other site 243090006851 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 243090006852 dimer interface [polypeptide binding]; other site 243090006853 ADP-glucose phosphorylase; Region: PLN02643 243090006854 active site 243090006855 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 243090006856 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243090006857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 243090006858 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 243090006859 TolA protein; Region: tolA_full; TIGR02794 243090006860 ATPase involved in DNA repair; Region: DUF3686; pfam12458 243090006861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090006862 Walker A motif; other site 243090006863 ATP binding site [chemical binding]; other site 243090006864 Walker B motif; other site 243090006865 arginine finger; other site 243090006866 cosmid pircos-a3e04/ cosmid pircos-c4h05 joining point 243090006867 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 243090006868 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 243090006869 TPR repeat; Region: TPR_11; pfam13414 243090006870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090006871 binding surface 243090006872 TPR motif; other site 243090006873 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243090006874 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090006875 TPR motif; other site 243090006876 binding surface 243090006877 Tetratricopeptide repeat; Region: TPR_19; pfam14559 243090006878 Protein of unknown function (DUF1582); Region: DUF1582; pfam07621 243090006879 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 243090006880 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 243090006881 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 243090006882 dimer interface [polypeptide binding]; other site 243090006883 active site 243090006884 citrylCoA binding site [chemical binding]; other site 243090006885 NADH binding [chemical binding]; other site 243090006886 cationic pore residues; other site 243090006887 oxalacetate/citrate binding site [chemical binding]; other site 243090006888 coenzyme A binding site [chemical binding]; other site 243090006889 catalytic triad [active] 243090006890 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090006891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090006892 active site 243090006893 phosphorylation site [posttranslational modification] 243090006894 intermolecular recognition site; other site 243090006895 dimerization interface [polypeptide binding]; other site 243090006896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243090006897 DNA binding site [nucleotide binding] 243090006898 superoxide dismutase; Provisional; Region: PRK10925 243090006899 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 243090006900 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 243090006901 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 243090006902 intersubunit interface [polypeptide binding]; other site 243090006903 active site 243090006904 zinc binding site [ion binding]; other site 243090006905 Na+ binding site [ion binding]; other site 243090006906 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 243090006907 active site 243090006908 NTP binding site [chemical binding]; other site 243090006909 metal binding triad [ion binding]; metal-binding site 243090006910 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 243090006911 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 243090006912 cosmid pircos-c4h05/ cosmid pircos-a1d12 joining point 243090006913 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243090006914 putative transposase OrfB; Reviewed; Region: PHA02517 243090006915 HTH-like domain; Region: HTH_21; pfam13276 243090006916 Integrase core domain; Region: rve; pfam00665 243090006917 Integrase core domain; Region: rve_3; pfam13683 243090006918 Transposase; Region: HTH_Tnp_1; cl17663 243090006919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 243090006920 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243090006921 Ligand Binding Site [chemical binding]; other site 243090006922 Citrate transporter; Region: CitMHS; pfam03600 243090006923 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 243090006924 transmembrane helices; other site 243090006925 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090006926 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090006927 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090006928 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090006929 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243090006930 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 243090006931 intersubunit interface [polypeptide binding]; other site 243090006932 active site 243090006933 catalytic residue [active] 243090006934 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 243090006935 active site 243090006936 oxyanion hole [active] 243090006937 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 243090006938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090006939 TPR motif; other site 243090006940 catalytic triad [active] 243090006941 Protein of unknown function (DUF1581); Region: DUF1581; pfam07619 243090006942 Protein of unknown function (DUF1583); Region: DUF1583; pfam07622 243090006943 DDE superfamily endonuclease; Region: DDE_5; pfam13546 243090006944 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 243090006945 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 243090006946 arsenite S-adenosylmethyltransferase; Reviewed; Region: arsM; PRK11873 243090006947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090006948 S-adenosylmethionine binding site [chemical binding]; other site 243090006949 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 243090006950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090006951 FeS/SAM binding site; other site 243090006952 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 243090006953 cosmid pircos-a1d12/ cosmid pircos-a4c05 joining point 243090006954 Clp protease ATP binding subunit; Region: clpC; CHL00095 243090006955 Clp amino terminal domain; Region: Clp_N; pfam02861 243090006956 Clp amino terminal domain; Region: Clp_N; pfam02861 243090006957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090006958 Walker A motif; other site 243090006959 ATP binding site [chemical binding]; other site 243090006960 Walker B motif; other site 243090006961 arginine finger; other site 243090006962 UvrB/uvrC motif; Region: UVR; pfam02151 243090006963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090006964 Walker A motif; other site 243090006965 ATP binding site [chemical binding]; other site 243090006966 Walker B motif; other site 243090006967 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 243090006968 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 243090006969 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 243090006970 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 243090006971 peptide synthase; Provisional; Region: PRK09274 243090006972 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 243090006973 acyl-activating enzyme (AAE) consensus motif; other site 243090006974 putative AMP binding site [chemical binding]; other site 243090006975 putative active site [active] 243090006976 putative CoA binding site [chemical binding]; other site 243090006977 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243090006978 methenyltetrahydromethanopterin cyclohydrolase; Region: one_C_mch; TIGR03120 243090006979 trimer interface I [polypeptide binding]; other site 243090006980 putative substrate binding pocket [chemical binding]; other site 243090006981 trimer interface II [polypeptide binding]; other site 243090006982 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 243090006983 putative catalytic residues [active] 243090006984 Ecdysteroid kinase; Region: EcKinase; pfam02958 243090006985 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090006986 Sulfatase; Region: Sulfatase; pfam00884 243090006987 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 243090006988 Part of AAA domain; Region: AAA_19; pfam13245 243090006989 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 243090006990 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 243090006991 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 243090006992 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090006993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090006994 DNA binding residues [nucleotide binding] 243090006995 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090006996 Sulfatase; Region: Sulfatase; pfam00884 243090006997 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243090006998 EamA-like transporter family; Region: EamA; pfam00892 243090006999 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090007000 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090007001 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090007002 Methane oxygenase PmoA; Region: PmoA; pfam14100 243090007003 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 243090007004 classical (c) SDRs; Region: SDR_c; cd05233 243090007005 NAD(P) binding site [chemical binding]; other site 243090007006 active site 243090007007 Domain of unknown function (DUF303); Region: DUF303; pfam03629 243090007008 cosmid pircos-a4c05/ cosmid pircos-d2d10 joining point 243090007009 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 243090007010 lipoyl attachment site [posttranslational modification]; other site 243090007011 thiamine monophosphate kinase; Provisional; Region: PRK05731 243090007012 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 243090007013 ATP binding site [chemical binding]; other site 243090007014 dimerization interface [polypeptide binding]; other site 243090007015 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243090007016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090007017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090007018 dimer interface [polypeptide binding]; other site 243090007019 phosphorylation site [posttranslational modification] 243090007020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090007021 ATP binding site [chemical binding]; other site 243090007022 Mg2+ binding site [ion binding]; other site 243090007023 G-X-G motif; other site 243090007024 aspartate aminotransferase; Provisional; Region: PRK06290 243090007025 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243090007026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090007027 homodimer interface [polypeptide binding]; other site 243090007028 catalytic residue [active] 243090007029 chorismate synthase; Validated; Region: PRK05382 243090007030 Tetramer interface [polypeptide binding]; other site 243090007031 active site 243090007032 FMN-binding site [chemical binding]; other site 243090007033 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 243090007034 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 243090007035 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090007036 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243090007037 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090007038 DNA binding residues [nucleotide binding] 243090007039 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 243090007040 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 243090007041 metal binding triad [ion binding]; metal-binding site 243090007042 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 243090007043 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243090007044 metal binding triad; other site 243090007045 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 243090007046 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090007047 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090007048 active site 243090007049 ATP binding site [chemical binding]; other site 243090007050 substrate binding site [chemical binding]; other site 243090007051 activation loop (A-loop); other site 243090007052 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243090007053 nucleotide binding site [chemical binding]; other site 243090007054 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 243090007055 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 243090007056 domain interfaces; other site 243090007057 active site 243090007058 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 243090007059 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243090007060 inhibitor-cofactor binding pocket; inhibition site 243090007061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090007062 catalytic residue [active] 243090007063 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 243090007064 Substrate binding site; other site 243090007065 Mg++ binding site; other site 243090007066 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 243090007067 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 243090007068 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243090007069 active site 243090007070 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 243090007071 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243090007072 cytoskeletal protein RodZ; Provisional; Region: PRK10856 243090007073 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090007074 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090007075 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090007076 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090007077 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090007078 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090007079 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090007080 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 243090007081 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090007082 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090007083 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 243090007084 Protein of unknown function (DUF998); Region: DUF998; pfam06197 243090007085 SLA1 homology domain 1, SHD1; Region: SHD1; pfam03983 243090007086 Protein of unknown function (DUF1570); Region: DUF1570; pfam07607 243090007087 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090007088 Sulfatase; Region: Sulfatase; pfam00884 243090007089 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090007090 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 243090007091 active site 243090007092 catalytic triad [active] 243090007093 oxyanion hole [active] 243090007094 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 243090007095 FtsX-like permease family; Region: FtsX; pfam02687 243090007096 cosmid pircos-d2d10/ cosmid pircos-a3e05 joining point 243090007097 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243090007098 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243090007099 Walker A/P-loop; other site 243090007100 ATP binding site [chemical binding]; other site 243090007101 Q-loop/lid; other site 243090007102 ABC transporter signature motif; other site 243090007103 Walker B; other site 243090007104 D-loop; other site 243090007105 H-loop/switch region; other site 243090007106 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243090007107 metal binding site [ion binding]; metal-binding site 243090007108 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090007109 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 243090007110 Tail-tube assembly protein; Region: T4_tail_cap; pfam11091 243090007111 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 243090007112 O-Antigen ligase; Region: Wzy_C; pfam04932 243090007113 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 243090007114 Mg++ binding site [ion binding]; other site 243090007115 putative catalytic motif [active] 243090007116 substrate binding site [chemical binding]; other site 243090007117 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090007118 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090007119 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090007120 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090007121 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090007122 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090007123 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090007124 Protein of unknown function (DUF1501); Region: DUF1501; cl19855 243090007125 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090007126 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090007127 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090007128 Phage small terminase subunit; Region: Phage_term_smal; cl19614 243090007129 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243090007130 HrpJ-like domain; Region: HrpJ; cl15454 243090007131 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090007132 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090007133 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090007134 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090007135 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 243090007136 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090007137 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090007138 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090007139 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090007140 glutamate dehydrogenase; Region: PLN02477 243090007141 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 243090007142 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 243090007143 NAD(P) binding site [chemical binding]; other site 243090007144 cysteine synthase; Region: PLN02565 243090007145 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 243090007146 dimer interface [polypeptide binding]; other site 243090007147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090007148 catalytic residue [active] 243090007149 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 243090007150 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 243090007151 TPP-binding site [chemical binding]; other site 243090007152 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 243090007153 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 243090007154 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 243090007155 dimer interface [polypeptide binding]; other site 243090007156 PYR/PP interface [polypeptide binding]; other site 243090007157 TPP binding site [chemical binding]; other site 243090007158 substrate binding site [chemical binding]; other site 243090007159 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243090007160 dimerization interface [polypeptide binding]; other site 243090007161 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 243090007162 cyclase homology domain; Region: CHD; cd07302 243090007163 nucleotidyl binding site; other site 243090007164 metal binding site [ion binding]; metal-binding site 243090007165 dimer interface [polypeptide binding]; other site 243090007166 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 243090007167 Integral membrane diacylglycerol kinase and similar enzymes; Region: DAGK_IM_like; cd14263 243090007168 trimer interface [polypeptide binding]; other site 243090007169 putative active site [active] 243090007170 Zn binding site [ion binding]; other site 243090007171 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 243090007172 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090007173 Sulfatase; Region: Sulfatase; pfam00884 243090007174 Bacterial PH domain; Region: bPH_2; pfam03703 243090007175 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 243090007176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090007177 Walker A motif; other site 243090007178 ATP binding site [chemical binding]; other site 243090007179 Walker B motif; other site 243090007180 arginine finger; other site 243090007181 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 243090007182 Predicted coiled-coil domain-containing protein (DUF2360); Region: DUF2360; pfam10152 243090007183 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 243090007184 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090007185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090007186 DNA binding residues [nucleotide binding] 243090007187 cosmid pircos-a3e05/ cosmid pircos-d1d11 joining point 243090007188 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 243090007189 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 243090007190 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243090007191 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090007192 FeS/SAM binding site; other site 243090007193 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090007194 Cytochrome c; Region: Cytochrom_C; cl11414 243090007195 Domain of unknown function DUF20; Region: UPF0118; cl00465 243090007196 Serine-rich region of AP3B1, clathrin-adaptor complex; Region: SEEEED; cl19208 243090007197 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243090007198 TORC1 subunit TCO89; Region: TCO89; pfam10452 243090007199 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090007200 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090007201 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090007202 cosmid pircos-d1d11/ cosmid gap joining point 243090007203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090007204 S-adenosylmethionine binding site [chemical binding]; other site 243090007205 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 243090007206 substrate binding site; other site 243090007207 dimerization interface; other site 243090007208 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 243090007209 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 243090007210 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090007211 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243090007212 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243090007213 Walker A/P-loop; other site 243090007214 ATP binding site [chemical binding]; other site 243090007215 Q-loop/lid; other site 243090007216 ABC transporter signature motif; other site 243090007217 Walker B; other site 243090007218 D-loop; other site 243090007219 H-loop/switch region; other site 243090007220 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243090007221 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 243090007222 FtsX-like permease family; Region: FtsX; pfam02687 243090007223 cosmid gap/ cosmid pircos-d1a04 joining point 243090007224 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090007225 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090007226 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 243090007227 HEAT repeats; Region: HEAT_2; pfam13646 243090007228 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 243090007229 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243090007230 Active Sites [active] 243090007231 Rrf2 family protein; Region: rrf2_super; TIGR00738 243090007232 Transcriptional regulator; Region: Rrf2; pfam02082 243090007233 flagellin; Provisional; Region: PRK12806 243090007234 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 243090007235 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 243090007236 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 243090007237 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 243090007238 GIY-YIG motif/motif A; other site 243090007239 active site 243090007240 catalytic site [active] 243090007241 metal binding site [ion binding]; metal-binding site 243090007242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243090007243 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 243090007244 NAD(P) binding site [chemical binding]; other site 243090007245 active site 243090007246 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 243090007247 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 243090007248 HflX GTPase family; Region: HflX; cd01878 243090007249 G1 box; other site 243090007250 GTP/Mg2+ binding site [chemical binding]; other site 243090007251 Switch I region; other site 243090007252 G2 box; other site 243090007253 G3 box; other site 243090007254 Switch II region; other site 243090007255 G4 box; other site 243090007256 G5 box; other site 243090007257 excinuclease ABC subunit C; Reviewed; Region: uvrC; PRK12306 243090007258 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 243090007259 GIY-YIG motif/motif A; other site 243090007260 active site 243090007261 catalytic site [active] 243090007262 putative DNA binding site [nucleotide binding]; other site 243090007263 metal binding site [ion binding]; metal-binding site 243090007264 UvrB/uvrC motif; Region: UVR; pfam02151 243090007265 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 243090007266 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 243090007267 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 243090007268 active site 243090007269 SAM binding site [chemical binding]; other site 243090007270 homodimer interface [polypeptide binding]; other site 243090007271 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 243090007272 active site 243090007273 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 243090007274 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 243090007275 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 243090007276 Asp-box motif; other site 243090007277 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090007278 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090007279 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090007280 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090007281 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090007282 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090007283 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090007284 YTV; Region: YTV; pfam07639 243090007285 YTV; Region: YTV; pfam07639 243090007286 MFS/sugar transport protein; Region: MFS_2; pfam13347 243090007287 GAF domain; Region: GAF_3; pfam13492 243090007288 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090007289 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090007290 active site 243090007291 ATP binding site [chemical binding]; other site 243090007292 substrate binding site [chemical binding]; other site 243090007293 activation loop (A-loop); other site 243090007294 cosmid pircos-d1a04/ cosmid pircos-d3f11 joining point 243090007295 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 243090007296 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 243090007297 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 243090007298 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 243090007299 FtsX-like permease family; Region: FtsX; pfam02687 243090007300 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 243090007301 FtsX-like permease family; Region: FtsX; pfam02687 243090007302 Outer membrane efflux protein; Region: OEP; pfam02321 243090007303 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243090007304 Outer membrane efflux protein; Region: OEP; pfam02321 243090007305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243090007306 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243090007307 NAD(P) binding site [chemical binding]; other site 243090007308 active site 243090007309 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 243090007310 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 243090007311 DRTGG domain; Region: DRTGG; pfam07085 243090007312 CBS domain; Region: CBS; pfam00571 243090007313 DHH family; Region: DHH; pfam01368 243090007314 DHHA2 domain; Region: DHHA2; pfam02833 243090007315 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 243090007316 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192 243090007317 Guanylate kinase; Region: Guanylate_kin; pfam00625 243090007318 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 243090007319 catalytic site [active] 243090007320 G-X2-G-X-G-K; other site 243090007321 hypothetical protein; Provisional; Region: PRK11820 243090007322 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 243090007323 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 243090007324 protein translocase, SecG subunit; Region: secG; TIGR00810 243090007325 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 243090007326 substrate binding site [chemical binding]; other site 243090007327 dimer interface [polypeptide binding]; other site 243090007328 catalytic triad [active] 243090007329 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 243090007330 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 243090007331 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090007332 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090007333 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090007334 DNA binding residues [nucleotide binding] 243090007335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 243090007336 von Willebrand factor; Region: vWF_A; pfam12450 243090007337 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 243090007338 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 243090007339 metal ion-dependent adhesion site (MIDAS); other site 243090007340 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 243090007341 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 243090007342 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 243090007343 SPFH domain / Band 7 family; Region: Band_7; pfam01145 243090007344 prohibitin homologues; Region: PHB; smart00244 243090007345 SPFH domain / Band 7 family; Region: Band_7; pfam01145 243090007346 Protein of unknown function (DUF1589); Region: DUF1589; pfam07628 243090007347 Protein of unknown function (DUF1589); Region: DUF1589; pfam07628 243090007348 Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072 243090007349 B3/4 domain; Region: B3_4; pfam03483 243090007350 tRNA synthetase B5 domain; Region: B5; smart00874 243090007351 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243090007352 motif 1; other site 243090007353 dimer interface [polypeptide binding]; other site 243090007354 active site 243090007355 motif 2; other site 243090007356 motif 3; other site 243090007357 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 243090007358 cosmid pircos-d3f11/ cosmid pircos-d2a02 joining point 243090007359 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 243090007360 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 243090007361 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 243090007362 dimer interface [polypeptide binding]; other site 243090007363 motif 1; other site 243090007364 active site 243090007365 motif 2; other site 243090007366 motif 3; other site 243090007367 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 243090007368 23S rRNA binding site [nucleotide binding]; other site 243090007369 L21 binding site [polypeptide binding]; other site 243090007370 L13 binding site [polypeptide binding]; other site 243090007371 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 243090007372 Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972 243090007373 PQQ-like domain; Region: PQQ_2; pfam13360 243090007374 Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972 243090007375 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243090007376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090007377 active site 243090007378 phosphorylation site [posttranslational modification] 243090007379 intermolecular recognition site; other site 243090007380 FeoA domain; Region: FeoA; pfam04023 243090007381 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 243090007382 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 243090007383 G1 box; other site 243090007384 GTP/Mg2+ binding site [chemical binding]; other site 243090007385 Switch I region; other site 243090007386 G2 box; other site 243090007387 G3 box; other site 243090007388 Switch II region; other site 243090007389 G4 box; other site 243090007390 G5 box; other site 243090007391 Nucleoside recognition; Region: Gate; pfam07670 243090007392 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 243090007393 Nucleoside recognition; Region: Gate; pfam07670 243090007394 mce related protein; Region: MCE; pfam02470 243090007395 Proline-rich; Region: Pro-rich; pfam15240 243090007396 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 243090007397 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 243090007398 Walker A/P-loop; other site 243090007399 ATP binding site [chemical binding]; other site 243090007400 Q-loop/lid; other site 243090007401 ABC transporter signature motif; other site 243090007402 Walker B; other site 243090007403 D-loop; other site 243090007404 H-loop/switch region; other site 243090007405 Permease; Region: Permease; pfam02405 243090007406 hypothetical protein; Provisional; Region: PHA02644 243090007407 Signal recognition particle, alpha subunit, N-terminal; Region: SRP-alpha_N; pfam04086 243090007408 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 243090007409 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 243090007410 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 243090007411 putative active site [active] 243090007412 putative metal binding site [ion binding]; other site 243090007413 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 243090007414 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 243090007415 putative ADP-binding pocket [chemical binding]; other site 243090007416 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243090007417 putative acyl-acceptor binding pocket; other site 243090007418 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090007419 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090007420 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 243090007421 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 243090007422 metal binding site [ion binding]; metal-binding site 243090007423 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 243090007424 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243090007425 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243090007426 Walker A/P-loop; other site 243090007427 ATP binding site [chemical binding]; other site 243090007428 Q-loop/lid; other site 243090007429 ABC transporter signature motif; other site 243090007430 Walker B; other site 243090007431 D-loop; other site 243090007432 H-loop/switch region; other site 243090007433 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 243090007434 acyl carrier protein; Provisional; Region: acpP; PRK00982 243090007435 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 243090007436 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243090007437 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 243090007438 dimer interface [polypeptide binding]; other site 243090007439 active site 243090007440 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 243090007441 substrate binding pocket [chemical binding]; other site 243090007442 chain length determination region; other site 243090007443 substrate-Mg2+ binding site; other site 243090007444 catalytic residues [active] 243090007445 aspartate-rich region 1; other site 243090007446 active site lid residues [active] 243090007447 aspartate-rich region 2; other site 243090007448 cosmid pircos-d2a02/ cosmid pircos-b2a06 joining point 243090007449 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 243090007450 trimer interface [polypeptide binding]; other site 243090007451 dimer interface [polypeptide binding]; other site 243090007452 putative active site [active] 243090007453 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 243090007454 DNA binding residues [nucleotide binding] 243090007455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090007456 active site 243090007457 phosphorylation site [posttranslational modification] 243090007458 intermolecular recognition site; other site 243090007459 dimerization interface [polypeptide binding]; other site 243090007460 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243090007461 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243090007462 phosphopeptide binding site; other site 243090007463 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 243090007464 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 243090007465 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 243090007466 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090007467 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090007468 Protein of unknown function (DUF1582); Region: DUF1582; pfam07621 243090007469 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 243090007470 putative active site [active] 243090007471 Penicillinase repressor; Region: Penicillinase_R; pfam03965 243090007472 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 243090007473 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 243090007474 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 243090007475 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 243090007476 GIY-YIG motif/motif A; other site 243090007477 active site 243090007478 catalytic site [active] 243090007479 putative DNA binding site [nucleotide binding]; other site 243090007480 metal binding site [ion binding]; metal-binding site 243090007481 UvrB/uvrC motif; Region: UVR; pfam02151 243090007482 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 243090007483 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 243090007484 ThiC family; Region: ThiC; pfam01964 243090007485 UvrB/uvrC motif; Region: UVR; pfam02151 243090007486 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 243090007487 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 243090007488 PhoU domain; Region: PhoU; pfam01895 243090007489 PhoU domain; Region: PhoU; pfam01895 243090007490 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 243090007491 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 243090007492 Walker A/P-loop; other site 243090007493 ATP binding site [chemical binding]; other site 243090007494 Q-loop/lid; other site 243090007495 ABC transporter signature motif; other site 243090007496 Walker B; other site 243090007497 D-loop; other site 243090007498 H-loop/switch region; other site 243090007499 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 243090007500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243090007501 ABC-ATPase subunit interface; other site 243090007502 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 243090007503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243090007504 dimer interface [polypeptide binding]; other site 243090007505 conserved gate region; other site 243090007506 putative PBP binding loops; other site 243090007507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 243090007508 ABC-ATPase subunit interface; other site 243090007509 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 243090007510 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 243090007511 Carbon starvation protein CstA; Region: CstA; pfam02554 243090007512 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 243090007513 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 243090007514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090007515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243090007516 Domain of unknown function (DUF303); Region: DUF303; pfam03629 243090007517 cosmid pircos-b2a06/ cosmid pircos-c3d02 joining point 243090007518 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090007519 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090007520 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090007521 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090007522 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090007523 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243090007524 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243090007525 Walker A/P-loop; other site 243090007526 ATP binding site [chemical binding]; other site 243090007527 Q-loop/lid; other site 243090007528 ABC transporter signature motif; other site 243090007529 Walker B; other site 243090007530 D-loop; other site 243090007531 H-loop/switch region; other site 243090007532 NIPSNAP; Region: NIPSNAP; pfam07978 243090007533 NIPSNAP; Region: NIPSNAP; pfam07978 243090007534 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 243090007535 MutS domain I; Region: MutS_I; pfam01624 243090007536 MutS domain II; Region: MutS_II; pfam05188 243090007537 MutS domain III; Region: MutS_III; pfam05192 243090007538 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 243090007539 Walker A/P-loop; other site 243090007540 ATP binding site [chemical binding]; other site 243090007541 Q-loop/lid; other site 243090007542 ABC transporter signature motif; other site 243090007543 Walker B; other site 243090007544 D-loop; other site 243090007545 H-loop/switch region; other site 243090007546 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090007547 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090007548 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 243090007549 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090007550 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090007551 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090007552 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 243090007553 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 243090007554 active site 243090007555 glutamine synthetase; Region: PLN02284 243090007556 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 243090007557 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 243090007558 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090007559 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090007560 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090007561 Ethylene insensitive 3; Region: EIN3; cl04813 243090007562 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 243090007563 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243090007564 active site 243090007565 HIGH motif; other site 243090007566 nucleotide binding site [chemical binding]; other site 243090007567 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243090007568 active site 243090007569 KMSKS motif; other site 243090007570 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 243090007571 tRNA binding surface [nucleotide binding]; other site 243090007572 anticodon binding site; other site 243090007573 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 243090007574 active site 243090007575 substrate binding site [chemical binding]; other site 243090007576 cosubstrate binding site; other site 243090007577 catalytic site [active] 243090007578 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090007579 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243090007580 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 243090007581 inhibitor-cofactor binding pocket; inhibition site 243090007582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090007583 catalytic residue [active] 243090007584 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243090007585 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 243090007586 acyl-activating enzyme (AAE) consensus motif; other site 243090007587 AMP binding site [chemical binding]; other site 243090007588 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243090007589 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 243090007590 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243090007591 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243090007592 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243090007593 cosmid pircos-c3d02/ cosmid pircos-a3d03 joining point 243090007594 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 243090007595 putative acyl-acceptor binding pocket; other site 243090007596 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 243090007597 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 243090007598 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 243090007599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243090007600 dimer interface [polypeptide binding]; other site 243090007601 conserved gate region; other site 243090007602 putative PBP binding loops; other site 243090007603 ABC-ATPase subunit interface; other site 243090007604 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 243090007605 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 243090007606 Walker A/P-loop; other site 243090007607 ATP binding site [chemical binding]; other site 243090007608 Q-loop/lid; other site 243090007609 ABC transporter signature motif; other site 243090007610 Walker B; other site 243090007611 D-loop; other site 243090007612 H-loop/switch region; other site 243090007613 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 243090007614 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 243090007615 classical (c) SDRs; Region: SDR_c; cd05233 243090007616 NAD(P) binding site [chemical binding]; other site 243090007617 active site 243090007618 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 243090007619 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 243090007620 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243090007621 TrkA-C domain; Region: TrkA_C; pfam02080 243090007622 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 243090007623 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090007624 ATP binding site [chemical binding]; other site 243090007625 putative Mg++ binding site [ion binding]; other site 243090007626 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090007627 nucleotide binding region [chemical binding]; other site 243090007628 ATP-binding site [chemical binding]; other site 243090007629 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 243090007630 putative ligand binding site [chemical binding]; other site 243090007631 PAS domain S-box; Region: sensory_box; TIGR00229 243090007632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090007633 putative active site [active] 243090007634 heme pocket [chemical binding]; other site 243090007635 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243090007636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090007637 dimer interface [polypeptide binding]; other site 243090007638 phosphorylation site [posttranslational modification] 243090007639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090007640 ATP binding site [chemical binding]; other site 243090007641 Mg2+ binding site [ion binding]; other site 243090007642 G-X-G motif; other site 243090007643 cosmid pircos-a3d03/ cosmid pircos-c4e12 joining point 243090007644 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 243090007645 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 243090007646 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 243090007647 putative ligand binding site [chemical binding]; other site 243090007648 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243090007649 DEAD-like helicases superfamily; Region: DEXDc; smart00487 243090007650 ATP binding site [chemical binding]; other site 243090007651 Mg++ binding site [ion binding]; other site 243090007652 motif III; other site 243090007653 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090007654 nucleotide binding region [chemical binding]; other site 243090007655 ATP-binding site [chemical binding]; other site 243090007656 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090007657 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 243090007658 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 243090007659 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090007660 Right handed beta helix region; Region: Beta_helix; pfam13229 243090007661 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090007662 cosmid pircos-c4e12/ cosmid pircos-d1c12 joining point 243090007663 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 243090007664 putative catalytic cysteine [active] 243090007665 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 243090007666 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 243090007667 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 243090007668 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090007669 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090007670 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090007671 PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992 243090007672 protein binding site [polypeptide binding]; other site 243090007673 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 243090007674 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090007675 PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992 243090007676 protein binding site [polypeptide binding]; other site 243090007677 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 243090007678 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 243090007679 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243090007680 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243090007681 peptidase T-like protein; Region: PepT-like; TIGR01883 243090007682 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 243090007683 metal binding site [ion binding]; metal-binding site 243090007684 dimer interface [polypeptide binding]; other site 243090007685 Orbivirus RNA-dependent RNA polymerase (VP1); Region: Orbi_VP1; pfam05788 243090007686 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 243090007687 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 243090007688 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090007689 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090007690 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 243090007691 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 243090007692 NADP binding site [chemical binding]; other site 243090007693 homodimer interface [polypeptide binding]; other site 243090007694 active site 243090007695 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 243090007696 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 243090007697 Int/Topo IB signature motif; other site 243090007698 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 243090007699 Putative transposase; Region: Y2_Tnp; pfam04986 243090007700 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 243090007701 active site 243090007702 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 243090007703 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243090007704 active site 243090007705 DNA binding site [nucleotide binding] 243090007706 Int/Topo IB signature motif; other site 243090007707 cosmid pircos-d1c12/ cosmid pircos-d2f05 joining point 243090007708 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 243090007709 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 243090007710 putative active site [active] 243090007711 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 243090007712 putative active site [active] 243090007713 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243090007714 metal-binding site [ion binding] 243090007715 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 243090007716 C-terminal peptidase (prc); Region: prc; TIGR00225 243090007717 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 243090007718 protein binding site [polypeptide binding]; other site 243090007719 Catalytic dyad [active] 243090007720 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243090007721 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090007722 putative active site [active] 243090007723 heme pocket [chemical binding]; other site 243090007724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090007725 dimer interface [polypeptide binding]; other site 243090007726 phosphorylation site [posttranslational modification] 243090007727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090007728 ATP binding site [chemical binding]; other site 243090007729 Mg2+ binding site [ion binding]; other site 243090007730 G-X-G motif; other site 243090007731 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 243090007732 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090007733 Cytochrome c; Region: Cytochrom_C; cl11414 243090007734 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 243090007735 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243090007736 catalytic residue [active] 243090007737 quinolinate synthetase; Provisional; Region: PRK09375 243090007738 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 243090007739 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 243090007740 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 243090007741 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 243090007742 dihydroorotase; Validated; Region: pyrC; PRK09357 243090007743 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 243090007744 active site 243090007745 Ribonuclease P; Region: Ribonuclease_P; pfam00825 243090007746 Domain of unknown function (DUF368); Region: DUF368; pfam04018 243090007747 Bacitracin resistance protein BacA; Region: BacA; pfam02673 243090007748 SOS regulatory protein LexA; Region: lexA; TIGR00498 243090007749 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 243090007750 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 243090007751 Catalytic site [active] 243090007752 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 243090007753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090007754 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 243090007755 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 243090007756 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 243090007757 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 243090007758 Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; Region: RNase_H_like; cl14782 243090007759 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 243090007760 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 243090007761 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 243090007762 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 243090007763 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 243090007764 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 243090007765 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 243090007766 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243090007767 catalytic residue [active] 243090007768 YTV; Region: YTV; pfam07639 243090007769 YTV; Region: YTV; pfam07639 243090007770 YTV; Region: YTV; pfam07639 243090007771 cosmid pircos-d2f05/ cosmid pircos-a2g04 joining point 243090007772 PAS fold; Region: PAS_4; pfam08448 243090007773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090007774 putative active site [active] 243090007775 heme pocket [chemical binding]; other site 243090007776 GAF domain; Region: GAF; pfam01590 243090007777 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 243090007778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090007779 active site 243090007780 phosphorylation site [posttranslational modification] 243090007781 intermolecular recognition site; other site 243090007782 dimerization interface [polypeptide binding]; other site 243090007783 sulfite reductase subunit beta; Provisional; Region: PRK13504 243090007784 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243090007785 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 243090007786 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243090007787 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243090007788 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 243090007789 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 243090007790 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 243090007791 homodimer interface [polypeptide binding]; other site 243090007792 NADP binding site [chemical binding]; other site 243090007793 substrate binding site [chemical binding]; other site 243090007794 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090007795 N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; Region: Tweety_N; cl12141 243090007796 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243090007797 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243090007798 PAS fold; Region: PAS_4; pfam08448 243090007799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090007800 putative active site [active] 243090007801 heme pocket [chemical binding]; other site 243090007802 PAS fold; Region: PAS_4; pfam08448 243090007803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090007804 heme pocket [chemical binding]; other site 243090007805 putative active site [active] 243090007806 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243090007807 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090007808 putative active site [active] 243090007809 heme pocket [chemical binding]; other site 243090007810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090007811 dimer interface [polypeptide binding]; other site 243090007812 phosphorylation site [posttranslational modification] 243090007813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090007814 ATP binding site [chemical binding]; other site 243090007815 Mg2+ binding site [ion binding]; other site 243090007816 G-X-G motif; other site 243090007817 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090007818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090007819 active site 243090007820 phosphorylation site [posttranslational modification] 243090007821 intermolecular recognition site; other site 243090007822 dimerization interface [polypeptide binding]; other site 243090007823 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 243090007824 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090007825 Sulfatase; Region: Sulfatase; pfam00884 243090007826 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090007827 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 243090007828 NAD binding site [chemical binding]; other site 243090007829 homotetramer interface [polypeptide binding]; other site 243090007830 homodimer interface [polypeptide binding]; other site 243090007831 active site 243090007832 substrate binding site [chemical binding]; other site 243090007833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090007834 dimer interface [polypeptide binding]; other site 243090007835 phosphorylation site [posttranslational modification] 243090007836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090007837 ATP binding site [chemical binding]; other site 243090007838 Mg2+ binding site [ion binding]; other site 243090007839 G-X-G motif; other site 243090007840 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 243090007841 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090007842 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090007843 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 243090007844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090007845 TPR motif; other site 243090007846 binding surface 243090007847 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 243090007848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090007849 TPR motif; other site 243090007850 binding surface 243090007851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090007852 TPR motif; other site 243090007853 binding surface 243090007854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090007855 TPR motif; other site 243090007856 binding surface 243090007857 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243090007858 Protein of unknown function (DUF1581); Region: DUF1581; pfam07619 243090007859 Protein of unknown function (DUF1583); Region: DUF1583; pfam07622 243090007860 cosmid pircos-a2g04/ cosmid pircos-c2f05 joining point 243090007861 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090007862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090007863 Walker A motif; other site 243090007864 ATP binding site [chemical binding]; other site 243090007865 Walker B motif; other site 243090007866 arginine finger; other site 243090007867 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090007868 metal ion-dependent adhesion site (MIDAS); other site 243090007869 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 243090007870 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090007871 metal ion-dependent adhesion site (MIDAS); other site 243090007872 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090007873 metal ion-dependent adhesion site (MIDAS); other site 243090007874 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243090007875 metal ion-dependent adhesion site (MIDAS); other site 243090007876 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 243090007877 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 243090007878 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 243090007879 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 243090007880 Na binding site [ion binding]; other site 243090007881 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 243090007882 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 243090007883 putative active site [active] 243090007884 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 243090007885 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243090007886 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243090007887 Cupin domain; Region: Cupin_2; cl17218 243090007888 PQQ-like domain; Region: PQQ_2; pfam13360 243090007889 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090007890 active site 243090007891 Trp docking motif [polypeptide binding]; other site 243090007892 nitrate reductase [NADPH]; Region: PLN02252 243090007893 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090007894 Trp docking motif [polypeptide binding]; other site 243090007895 active site 243090007896 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090007897 Trp docking motif [polypeptide binding]; other site 243090007898 active site 243090007899 PQQ-like domain; Region: PQQ_2; pfam13360 243090007900 cosmid pircos-c2f05/ cosmid pircos-b2g10 joining point 243090007901 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 243090007902 FAD binding site [chemical binding]; other site 243090007903 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 243090007904 TadE-like protein; Region: TadE; pfam07811 243090007905 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090007906 metal ion-dependent adhesion site (MIDAS); other site 243090007907 TadE-like protein; Region: TadE; pfam07811 243090007908 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090007909 Sulfatase; Region: Sulfatase; pfam00884 243090007910 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090007911 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243090007912 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 243090007913 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243090007914 catalytic residue [active] 243090007915 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 243090007916 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 243090007917 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 243090007918 DNA binding site [nucleotide binding] 243090007919 catalytic residue [active] 243090007920 H2TH interface [polypeptide binding]; other site 243090007921 putative catalytic residues [active] 243090007922 turnover-facilitating residue; other site 243090007923 intercalation triad [nucleotide binding]; other site 243090007924 8OG recognition residue [nucleotide binding]; other site 243090007925 putative reading head residues; other site 243090007926 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 243090007927 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 243090007928 active site 243090007929 ADP/pyrophosphate binding site [chemical binding]; other site 243090007930 dimerization interface [polypeptide binding]; other site 243090007931 allosteric effector site; other site 243090007932 fructose-1,6-bisphosphate binding site; other site 243090007933 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 243090007934 putative acyl-acceptor binding pocket; other site 243090007935 Global regulator protein family; Region: CsrA; pfam02599 243090007936 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243090007937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090007938 active site 243090007939 phosphorylation site [posttranslational modification] 243090007940 intermolecular recognition site; other site 243090007941 dimerization interface [polypeptide binding]; other site 243090007942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090007943 Walker A motif; other site 243090007944 ATP binding site [chemical binding]; other site 243090007945 Walker B motif; other site 243090007946 arginine finger; other site 243090007947 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243090007948 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 243090007949 dimer interface [polypeptide binding]; other site 243090007950 substrate binding site [chemical binding]; other site 243090007951 ATP binding site [chemical binding]; other site 243090007952 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 243090007953 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 243090007954 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243090007955 catalytic residue [active] 243090007956 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 243090007957 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243090007958 catalytic residue [active] 243090007959 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 243090007960 lipoyl attachment site [posttranslational modification]; other site 243090007961 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 243090007962 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 243090007963 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 243090007964 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 243090007965 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 243090007966 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 243090007967 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 243090007968 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 243090007969 cosmid pircos-b2g10/ cosmid pircos-c1f06 joining point 243090007970 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 243090007971 iron-sulfur cluster [ion binding]; other site 243090007972 [2Fe-2S] cluster binding site [ion binding]; other site 243090007973 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243090007974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 243090007975 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243090007976 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 243090007977 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 243090007978 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 243090007979 active site 243090007980 HIGH motif; other site 243090007981 KMSKS motif; other site 243090007982 Outer membrane efflux protein; Region: OEP; pfam02321 243090007983 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243090007984 Outer membrane efflux protein; Region: OEP; pfam02321 243090007985 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 243090007986 active site 243090007987 putative acetyltransferase; Provisional; Region: PRK03624 243090007988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090007989 Coenzyme A binding pocket [chemical binding]; other site 243090007990 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 243090007991 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 243090007992 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 243090007993 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243090007994 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 243090007995 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243090007996 Cysteine-rich domain; Region: CCG; pfam02754 243090007997 Cysteine-rich domain; Region: CCG; pfam02754 243090007998 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 243090007999 fumarate hydratase; Reviewed; Region: fumC; PRK00485 243090008000 Class II fumarases; Region: Fumarase_classII; cd01362 243090008001 active site 243090008002 tetramer interface [polypeptide binding]; other site 243090008003 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 243090008004 GntP family permease; Region: GntP_permease; pfam02447 243090008005 transmembrane helices; other site 243090008006 ribonuclease Y; Region: RNase_Y; TIGR03319 243090008007 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cd00105 243090008008 nucleic acid binding region [nucleotide binding]; other site 243090008009 G-X-X-G motif; other site 243090008010 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243090008011 Zn2+ binding site [ion binding]; other site 243090008012 Mg2+ binding site [ion binding]; other site 243090008013 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 243090008014 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 243090008015 Ligand Binding Site [chemical binding]; other site 243090008016 Mediator of CRAC channel activity; Region: Orai-1; pfam07856 243090008017 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 243090008018 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 243090008019 Walker A/P-loop; other site 243090008020 ATP binding site [chemical binding]; other site 243090008021 Q-loop/lid; other site 243090008022 ABC transporter signature motif; other site 243090008023 Walker B; other site 243090008024 D-loop; other site 243090008025 H-loop/switch region; other site 243090008026 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 243090008027 Acyltransferase family; Region: Acyl_transf_3; cl19154 243090008028 CAAX protease self-immunity; Region: Abi; pfam02517 243090008029 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 243090008030 Ligand binding site; other site 243090008031 Putative Catalytic site; other site 243090008032 DXD motif; other site 243090008033 malate dehydrogenase; Reviewed; Region: PRK06223 243090008034 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 243090008035 NAD(P) binding site [chemical binding]; other site 243090008036 dimer interface [polypeptide binding]; other site 243090008037 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243090008038 substrate binding site [chemical binding]; other site 243090008039 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 243090008040 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 243090008041 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243090008042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090008043 homodimer interface [polypeptide binding]; other site 243090008044 catalytic residue [active] 243090008045 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 243090008046 putative active site pocket [active] 243090008047 4-fold oligomerization interface [polypeptide binding]; other site 243090008048 metal binding residues [ion binding]; metal-binding site 243090008049 3-fold/trimer interface [polypeptide binding]; other site 243090008050 cosmid pircos-c1f06/ cosmid pircos-d2h07 joining point 243090008051 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 243090008052 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 243090008053 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 243090008054 dimer interface [polypeptide binding]; other site 243090008055 active site residues [active] 243090008056 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 243090008057 Cation transport protein; Region: TrkH; cl17365 243090008058 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 243090008059 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459 243090008060 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090008061 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090008062 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090008063 PSRT; Region: PSRT; pfam07636 243090008064 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090008065 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 243090008066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090008067 TPR repeat; Region: TPR_11; pfam13414 243090008068 binding surface 243090008069 TPR motif; other site 243090008070 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 243090008071 MPT binding site; other site 243090008072 trimer interface [polypeptide binding]; other site 243090008073 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 243090008074 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 243090008075 active site 243090008076 phosphorylation site [posttranslational modification] 243090008077 Protein of unknown function (DUF1582); Region: DUF1582; pfam07621 243090008078 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 243090008079 active site 243090008080 catalytic triad [active] 243090008081 oxyanion hole [active] 243090008082 GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]; Region: BMS1; COG5192 243090008083 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 243090008084 YcxB-like protein; Region: YcxB; pfam14317 243090008085 Protein of unknown function (DUF1570); Region: DUF1570; pfam07607 243090008086 Zn binding site [ion binding]; other site 243090008087 HEAT repeats; Region: HEAT_2; pfam13646 243090008088 DNA polymerase (viral) N-terminal domain; Region: DNA_pol_viral_N; pfam00242 243090008089 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 243090008090 Autotransporter beta-domain; Region: Autotransporter; pfam03797 243090008091 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 243090008092 Predicted ATPase [General function prediction only]; Region: COG5293 243090008093 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 243090008094 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 243090008095 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243090008096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243090008097 non-specific DNA binding site [nucleotide binding]; other site 243090008098 salt bridge; other site 243090008099 sequence-specific DNA binding site [nucleotide binding]; other site 243090008100 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 243090008101 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090008102 cosmid pircos-d2h07/ cosmid pircos-a3b07 joining point 243090008103 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090008104 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090008105 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 243090008106 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090008107 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090008108 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090008109 Sulfatase; Region: Sulfatase; pfam00884 243090008110 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090008111 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090008112 Sulfatase; Region: Sulfatase; pfam00884 243090008113 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 243090008114 putative metal binding site [ion binding]; other site 243090008115 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 243090008116 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 243090008117 putative metal binding site [ion binding]; other site 243090008118 FMN-binding domain; Region: FMN_bind; pfam04205 243090008119 FMN-binding domain; Region: FMN_bind; pfam04205 243090008120 4Fe-4S binding domain; Region: Fer4_5; pfam12801 243090008121 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 243090008122 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 243090008123 cyclase homology domain; Region: CHD; cd07302 243090008124 nucleotidyl binding site; other site 243090008125 metal binding site [ion binding]; metal-binding site 243090008126 dimer interface [polypeptide binding]; other site 243090008127 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 243090008128 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 243090008129 Uncharacterized conserved protein [Function unknown]; Region: COG4278 243090008130 TIGR04222 domain; Region: near_uncomplex 243090008131 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090008132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090008133 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090008134 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090008135 active site 243090008136 ATP binding site [chemical binding]; other site 243090008137 substrate binding site [chemical binding]; other site 243090008138 activation loop (A-loop); other site 243090008139 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 243090008140 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 243090008141 active site 243090008142 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 243090008143 substrate binding site [chemical binding]; other site 243090008144 active site 243090008145 cosmid pircos-a3b07/ cosmid pircos-d1c09 joining point 243090008146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090008147 S-adenosylmethionine binding site [chemical binding]; other site 243090008148 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243090008149 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243090008150 substrate binding site [chemical binding]; other site 243090008151 oxyanion hole (OAH) forming residues; other site 243090008152 trimer interface [polypeptide binding]; other site 243090008153 Protein of unknown function DUF72; Region: DUF72; cl00777 243090008154 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 243090008155 S17 interaction site [polypeptide binding]; other site 243090008156 S8 interaction site; other site 243090008157 16S rRNA interaction site [nucleotide binding]; other site 243090008158 streptomycin interaction site [chemical binding]; other site 243090008159 23S rRNA interaction site [nucleotide binding]; other site 243090008160 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 243090008161 30S ribosomal protein S7; Validated; Region: PRK05302 243090008162 elongation factor G; Reviewed; Region: PRK12739 243090008163 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 243090008164 G1 box; other site 243090008165 putative GEF interaction site [polypeptide binding]; other site 243090008166 GTP/Mg2+ binding site [chemical binding]; other site 243090008167 Switch I region; other site 243090008168 G2 box; other site 243090008169 G3 box; other site 243090008170 Switch II region; other site 243090008171 G4 box; other site 243090008172 G5 box; other site 243090008173 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 243090008174 Elongation Factor G, domain II; Region: EFG_II; pfam14492 243090008175 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 243090008176 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 243090008177 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 243090008178 aminotransferase; Validated; Region: PRK08175 243090008179 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243090008180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090008181 homodimer interface [polypeptide binding]; other site 243090008182 catalytic residue [active] 243090008183 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 243090008184 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 243090008185 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 243090008186 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 243090008187 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 243090008188 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 243090008189 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 243090008190 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 243090008191 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 243090008192 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 243090008193 protein-rRNA interface [nucleotide binding]; other site 243090008194 putative translocon binding site; other site 243090008195 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 243090008196 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 243090008197 G-X-X-G motif; other site 243090008198 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 243090008199 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 243090008200 23S rRNA interface [nucleotide binding]; other site 243090008201 5S rRNA interface [nucleotide binding]; other site 243090008202 putative antibiotic binding site [chemical binding]; other site 243090008203 L25 interface [polypeptide binding]; other site 243090008204 L27 interface [polypeptide binding]; other site 243090008205 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 243090008206 23S rRNA interface [nucleotide binding]; other site 243090008207 putative translocon interaction site; other site 243090008208 signal recognition particle (SRP54) interaction site; other site 243090008209 L23 interface [polypeptide binding]; other site 243090008210 trigger factor interaction site; other site 243090008211 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 243090008212 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 243090008213 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 243090008214 RNA binding site [nucleotide binding]; other site 243090008215 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 243090008216 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 243090008217 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 243090008218 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 243090008219 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 243090008220 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 243090008221 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 243090008222 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 243090008223 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 243090008224 23S rRNA interface [nucleotide binding]; other site 243090008225 5S rRNA interface [nucleotide binding]; other site 243090008226 L27 interface [polypeptide binding]; other site 243090008227 L5 interface [polypeptide binding]; other site 243090008228 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 243090008229 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 243090008230 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 243090008231 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 243090008232 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 243090008233 SecY translocase; Region: SecY; pfam00344 243090008234 adenylate kinase; Reviewed; Region: adk; PRK00279 243090008235 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 243090008236 AMP-binding site [chemical binding]; other site 243090008237 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 243090008238 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 243090008239 putative catalytic residue [active] 243090008240 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 243090008241 active site 243090008242 catalytic triad [active] 243090008243 oxyanion hole [active] 243090008244 switch loop; other site 243090008245 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 243090008246 Sulfatase; Region: Sulfatase; pfam00884 243090008247 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090008248 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090008249 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090008250 Sulfatase; Region: Sulfatase; pfam00884 243090008251 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 243090008252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090008253 ATP binding site [chemical binding]; other site 243090008254 Mg2+ binding site [ion binding]; other site 243090008255 G-X-G motif; other site 243090008256 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 243090008257 ATP binding site [chemical binding]; other site 243090008258 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 243090008259 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 243090008260 elongation factor Tu; Reviewed; Region: PRK00049 243090008261 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 243090008262 G1 box; other site 243090008263 GEF interaction site [polypeptide binding]; other site 243090008264 GTP/Mg2+ binding site [chemical binding]; other site 243090008265 Switch I region; other site 243090008266 G2 box; other site 243090008267 G3 box; other site 243090008268 Switch II region; other site 243090008269 G4 box; other site 243090008270 G5 box; other site 243090008271 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 243090008272 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 243090008273 Antibiotic Binding Site [chemical binding]; other site 243090008274 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 243090008275 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 243090008276 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 243090008277 putative homodimer interface [polypeptide binding]; other site 243090008278 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 243090008279 heterodimer interface [polypeptide binding]; other site 243090008280 homodimer interface [polypeptide binding]; other site 243090008281 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 243090008282 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 243090008283 23S rRNA interface [nucleotide binding]; other site 243090008284 L7/L12 interface [polypeptide binding]; other site 243090008285 putative thiostrepton binding site; other site 243090008286 L25 interface [polypeptide binding]; other site 243090008287 methionine sulfoxide reductase B; Provisional; Region: PRK00222 243090008288 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 243090008289 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 243090008290 Walker A/P-loop; other site 243090008291 ATP binding site [chemical binding]; other site 243090008292 Q-loop/lid; other site 243090008293 ABC transporter signature motif; other site 243090008294 Walker B; other site 243090008295 D-loop; other site 243090008296 H-loop/switch region; other site 243090008297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090008298 S-adenosylmethionine binding site [chemical binding]; other site 243090008299 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 243090008300 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243090008301 substrate binding pocket [chemical binding]; other site 243090008302 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090008303 cosmid pircos-d1c09/ cosmid pircos-a2h04 joining point 243090008304 Gemmata obscuriglobus paralogous family TIGR03066; Region: Gem_osc_para_1 243090008305 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 243090008306 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090008307 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090008308 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090008309 active site 243090008310 ATP binding site [chemical binding]; other site 243090008311 substrate binding site [chemical binding]; other site 243090008312 activation loop (A-loop); other site 243090008313 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 243090008314 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090008315 DNA binding residues [nucleotide binding] 243090008316 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090008317 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090008318 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090008319 active site 243090008320 ATP binding site [chemical binding]; other site 243090008321 substrate binding site [chemical binding]; other site 243090008322 activation loop (A-loop); other site 243090008323 RDD family; Region: RDD; pfam06271 243090008324 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 243090008325 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 243090008326 active site 243090008327 Zn binding site [ion binding]; other site 243090008328 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 243090008329 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 243090008330 CysD dimerization site [polypeptide binding]; other site 243090008331 G1 box; other site 243090008332 putative GEF interaction site [polypeptide binding]; other site 243090008333 GTP/Mg2+ binding site [chemical binding]; other site 243090008334 Switch I region; other site 243090008335 G2 box; other site 243090008336 G3 box; other site 243090008337 Switch II region; other site 243090008338 G4 box; other site 243090008339 G5 box; other site 243090008340 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 243090008341 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 243090008342 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 243090008343 ligand-binding site [chemical binding]; other site 243090008344 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 243090008345 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243090008346 Active Sites [active] 243090008347 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; cl17726 243090008348 TPR repeat; Region: TPR_11; pfam13414 243090008349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090008350 TPR motif; other site 243090008351 binding surface 243090008352 TPR repeat; Region: TPR_11; pfam13414 243090008353 TPR repeat; Region: TPR_11; pfam13414 243090008354 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 243090008355 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 243090008356 active site 243090008357 interdomain interaction site; other site 243090008358 putative metal-binding site [ion binding]; other site 243090008359 nucleotide binding site [chemical binding]; other site 243090008360 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 243090008361 domain I; other site 243090008362 DNA binding groove [nucleotide binding] 243090008363 phosphate binding site [ion binding]; other site 243090008364 domain II; other site 243090008365 domain III; other site 243090008366 nucleotide binding site [chemical binding]; other site 243090008367 catalytic site [active] 243090008368 domain IV; other site 243090008369 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 243090008370 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 243090008371 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 243090008372 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 243090008373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243090008374 Walker A/P-loop; other site 243090008375 ATP binding site [chemical binding]; other site 243090008376 Q-loop/lid; other site 243090008377 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243090008378 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 243090008379 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 243090008380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243090008381 Walker A/P-loop; other site 243090008382 ATP binding site [chemical binding]; other site 243090008383 Q-loop/lid; other site 243090008384 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243090008385 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 243090008386 cosmid pircos-a2h04/ cosmid pircos-c2h02 joining point 243090008387 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 243090008388 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 243090008389 ADP binding site [chemical binding]; other site 243090008390 phosphagen binding site; other site 243090008391 substrate specificity loop; other site 243090008392 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 243090008393 hypothetical protein; Region: PHA02325 243090008394 UvrB/uvrC motif; Region: UVR; pfam02151 243090008395 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 243090008396 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 243090008397 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 243090008398 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; cl19625 243090008399 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 243090008400 active site 243090008401 catalytic triad [active] 243090008402 oxyanion hole [active] 243090008403 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090008404 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243090008405 Cytochrome c; Region: Cytochrom_C; pfam00034 243090008406 Cytochrome c; Region: Cytochrom_C; cl11414 243090008407 Cupredoxin superfamily; Region: Cupredoxin; cl19115 243090008408 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 243090008409 catalytic nucleophile [active] 243090008410 Domain of unknown function (DUF4440); Region: DUF4440; pfam14534 243090008411 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090008412 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090008413 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090008414 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090008415 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090008416 arylsulfatase; Provisional; Region: PRK13759 243090008417 Sulfatase; Region: Sulfatase; pfam00884 243090008418 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 243090008419 cosmid pircos-c2h02/ cosmid pircos-d2g12 joining point 243090008420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243090008421 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090008422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243090008423 active site 243090008424 Class I aldolases; Region: Aldolase_Class_I; cl17187 243090008425 catalytic residue [active] 243090008426 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090008427 Sulfatase; Region: Sulfatase; pfam00884 243090008428 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090008429 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090008430 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090008431 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 243090008432 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 243090008433 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 243090008434 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 243090008435 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090008436 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090008437 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090008438 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090008439 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090008440 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090008441 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090008442 Uncharacterized conserved protein [Function unknown]; Region: COG1262 243090008443 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 243090008444 ECF sigma factor; Region: Sigma70_ECF; pfam07638 243090008445 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090008446 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090008447 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090008448 active site 243090008449 ATP binding site [chemical binding]; other site 243090008450 substrate binding site [chemical binding]; other site 243090008451 activation loop (A-loop); other site 243090008452 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 243090008453 short chain dehydrogenase; Provisional; Region: PRK12937 243090008454 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 243090008455 NADP binding site [chemical binding]; other site 243090008456 homodimer interface [polypeptide binding]; other site 243090008457 active site 243090008458 substrate binding site [chemical binding]; other site 243090008459 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090008460 Sulfatase; Region: Sulfatase; pfam00884 243090008461 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 243090008462 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 243090008463 TrkA-N domain; Region: TrkA_N; pfam02254 243090008464 TrkA-N domain; Region: TrkA_N; pfam02254 243090008465 TrkA-C domain; Region: TrkA_C; pfam02080 243090008466 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 243090008467 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 243090008468 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 243090008469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243090008470 motif II; other site 243090008471 5-oxoprolinase; Region: PLN02666 243090008472 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 243090008473 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 243090008474 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 243090008475 PQQ-like domain; Region: PQQ_2; pfam13360 243090008476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090008477 PQQ-like domain; Region: PQQ_2; pfam13360 243090008478 cosmid pircos-d2g12/ cosmid pircos-d1d02 joining point 243090008479 DevC protein; Region: devC; TIGR01185 243090008480 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243090008481 FtsX-like permease family; Region: FtsX; pfam02687 243090008482 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 243090008483 ATP cone domain; Region: ATP-cone; pfam03477 243090008484 Bacterial PH domain; Region: bPH_2; pfam03703 243090008485 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 243090008486 Transcription initiation factor IIE, alpha subunit [Transcription]; Region: TFA1; COG1675 243090008487 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 243090008488 ribonuclease E; Reviewed; Region: rne; PRK10811 243090008489 ribonuclease E; Reviewed; Region: rne; PRK10811 243090008490 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 243090008491 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243090008492 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 243090008493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090008494 putative Mg++ binding site [ion binding]; other site 243090008495 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 243090008496 Double zinc ribbon; Region: DZR; pfam12773 243090008497 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 243090008498 Cell division protein FtsA; Region: FtsA; cl17206 243090008499 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 243090008500 active site 243090008501 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 243090008502 Peptidase family C25; Region: Peptidase_C25; pfam01364 243090008503 active site 243090008504 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090008505 Sulfatase; Region: Sulfatase; pfam00884 243090008506 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090008507 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 243090008508 catalytic residues [active] 243090008509 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 243090008510 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 243090008511 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 243090008512 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090008513 Trp docking motif [polypeptide binding]; other site 243090008514 active site 243090008515 PQQ-like domain; Region: PQQ_2; pfam13360 243090008516 PEP-CTERM motif; Region: VPEP; pfam07589 243090008517 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090008518 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 243090008519 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090008520 cosmid pircos-d1d02/ cosmid pircos-d3d05 joining point 243090008521 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090008522 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090008523 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090008524 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 243090008525 Protein of unknown function (DUF1589); Region: DUF1589; pfam07628 243090008526 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243090008527 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243090008528 Walker A/P-loop; other site 243090008529 ATP binding site [chemical binding]; other site 243090008530 Q-loop/lid; other site 243090008531 ABC transporter signature motif; other site 243090008532 Walker B; other site 243090008533 D-loop; other site 243090008534 H-loop/switch region; other site 243090008535 Predicted transcriptional regulators [Transcription]; Region: COG1725 243090008536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243090008537 DNA-binding site [nucleotide binding]; DNA binding site 243090008538 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 243090008539 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243090008540 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 243090008541 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 243090008542 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 243090008543 NAD binding site [chemical binding]; other site 243090008544 homotetramer interface [polypeptide binding]; other site 243090008545 homodimer interface [polypeptide binding]; other site 243090008546 substrate binding site [chemical binding]; other site 243090008547 active site 243090008548 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 243090008549 homodimer interface [polypeptide binding]; other site 243090008550 substrate-cofactor binding pocket; other site 243090008551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090008552 catalytic residue [active] 243090008553 recombination factor protein RarA; Reviewed; Region: PRK13342 243090008554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090008555 Walker A motif; other site 243090008556 ATP binding site [chemical binding]; other site 243090008557 Walker B motif; other site 243090008558 arginine finger; other site 243090008559 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 243090008560 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243090008561 catalytic residues [active] 243090008562 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 243090008563 Global regulator protein family; Region: CsrA; pfam02599 243090008564 Predicted transcriptional regulator [Transcription]; Region: COG1959 243090008565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 243090008566 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 243090008567 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090008568 metal ion-dependent adhesion site (MIDAS); other site 243090008569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090008570 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243090008571 Walker A motif; other site 243090008572 ATP binding site [chemical binding]; other site 243090008573 Walker B motif; other site 243090008574 arginine finger; other site 243090008575 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 243090008576 active site 243090008577 putative catalytic site [active] 243090008578 DNA binding site [nucleotide binding] 243090008579 putative phosphate binding site [ion binding]; other site 243090008580 metal binding site A [ion binding]; metal-binding site 243090008581 AP binding site [nucleotide binding]; other site 243090008582 metal binding site B [ion binding]; metal-binding site 243090008583 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 243090008584 Tetratricopeptide repeat; Region: TPR_19; pfam14559 243090008585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090008586 binding surface 243090008587 TPR motif; other site 243090008588 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 243090008589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090008590 binding surface 243090008591 TPR motif; other site 243090008592 TPR repeat; Region: TPR_11; pfam13414 243090008593 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 243090008594 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090008595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090008596 Walker A motif; other site 243090008597 ATP binding site [chemical binding]; other site 243090008598 Walker B motif; other site 243090008599 arginine finger; other site 243090008600 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243090008601 Protein of unknown function DUF58; Region: DUF58; pfam01882 243090008602 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243090008603 metal ion-dependent adhesion site (MIDAS); other site 243090008604 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 243090008605 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090008606 metal ion-dependent adhesion site (MIDAS); other site 243090008607 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 243090008608 Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340 243090008609 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 243090008610 Proline-rich; Region: Pro-rich; pfam15240 243090008611 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 243090008612 cosmid pircos-d3d05/ cosmid pircos-c3h11 joining point 243090008613 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090008614 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 243090008615 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 243090008616 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 243090008617 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243090008618 ATP binding site [chemical binding]; other site 243090008619 Mg++ binding site [ion binding]; other site 243090008620 motif III; other site 243090008621 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090008622 nucleotide binding region [chemical binding]; other site 243090008623 ATP-binding site [chemical binding]; other site 243090008624 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 243090008625 putative RNA binding site [nucleotide binding]; other site 243090008626 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090008627 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090008628 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090008629 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090008630 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090008631 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090008632 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 243090008633 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 243090008634 active site 243090008635 DNA binding site [nucleotide binding] 243090008636 guanine deaminase; Provisional; Region: PRK09228 243090008637 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243090008638 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243090008639 active site 243090008640 CAAX protease self-immunity; Region: Abi; pfam02517 243090008641 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 243090008642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243090008643 Walker A/P-loop; other site 243090008644 ATP binding site [chemical binding]; other site 243090008645 Q-loop/lid; other site 243090008646 ABC transporter signature motif; other site 243090008647 Walker B; other site 243090008648 D-loop; other site 243090008649 H-loop/switch region; other site 243090008650 Acyltransferase family; Region: Acyl_transf_3; cl19154 243090008651 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 243090008652 aspartate aminotransferase; Provisional; Region: PRK05764 243090008653 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243090008654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090008655 homodimer interface [polypeptide binding]; other site 243090008656 catalytic residue [active] 243090008657 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243090008658 homodimer interface [polypeptide binding]; other site 243090008659 substrate-cofactor binding pocket; other site 243090008660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090008661 catalytic residue [active] 243090008662 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 243090008663 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 243090008664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090008665 S-adenosylmethionine binding site [chemical binding]; other site 243090008666 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090008667 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090008668 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090008669 ACT domain-containing protein [General function prediction only]; Region: COG4747 243090008670 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 243090008671 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 243090008672 ferrochelatase; Reviewed; Region: hemH; PRK00035 243090008673 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 243090008674 C-terminal domain interface [polypeptide binding]; other site 243090008675 active site 243090008676 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 243090008677 active site 243090008678 N-terminal domain interface [polypeptide binding]; other site 243090008679 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 243090008680 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 243090008681 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 243090008682 dimer interface [polypeptide binding]; other site 243090008683 decamer (pentamer of dimers) interface [polypeptide binding]; other site 243090008684 catalytic triad [active] 243090008685 peroxidatic and resolving cysteines [active] 243090008686 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090008687 YidC periplasmic domain; Region: YidC_periplas; pfam14849 243090008688 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 243090008689 Protein of unknown function (DUF1582); Region: DUF1582; pfam07621 243090008690 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 243090008691 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 243090008692 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 243090008693 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 243090008694 dimer interface [polypeptide binding]; other site 243090008695 anticodon binding site; other site 243090008696 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 243090008697 homodimer interface [polypeptide binding]; other site 243090008698 motif 1; other site 243090008699 active site 243090008700 motif 2; other site 243090008701 GAD domain; Region: GAD; pfam02938 243090008702 motif 3; other site 243090008703 cosmid pircos-c3h11/ cosmid pircos-c1g10 joining point 243090008704 amino acid transporter; Region: 2A0306; TIGR00909 243090008705 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 243090008706 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 243090008707 Ligand Binding Site [chemical binding]; other site 243090008708 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243090008709 Ligand Binding Site [chemical binding]; other site 243090008710 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 243090008711 Proline dehydrogenase; Region: Pro_dh; pfam01619 243090008712 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 243090008713 Glutamate binding site [chemical binding]; other site 243090008714 NAD binding site [chemical binding]; other site 243090008715 catalytic residues [active] 243090008716 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243090008717 active site 243090008718 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 243090008719 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090008720 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 243090008721 TPR repeat; Region: TPR_11; pfam13414 243090008722 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243090008723 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243090008724 phosphopeptide binding site; other site 243090008725 GAF domain; Region: GAF_2; pfam13185 243090008726 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090008727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090008728 dimer interface [polypeptide binding]; other site 243090008729 phosphorylation site [posttranslational modification] 243090008730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090008731 ATP binding site [chemical binding]; other site 243090008732 Mg2+ binding site [ion binding]; other site 243090008733 G-X-G motif; other site 243090008734 clan AA aspartic protease, AF_0612 family; Region: clan_AA_DTGF; TIGR03698 243090008735 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 243090008736 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 243090008737 DHH family; Region: DHH; pfam01368 243090008738 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 243090008739 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 243090008740 active site 243090008741 Riboflavin kinase; Region: Flavokinase; pfam01687 243090008742 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 243090008743 putative substrate binding site [chemical binding]; other site 243090008744 putative ATP binding site [chemical binding]; other site 243090008745 Ion channel; Region: Ion_trans_2; pfam07885 243090008746 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 243090008747 TrkA-N domain; Region: TrkA_N; pfam02254 243090008748 TrkA-C domain; Region: TrkA_C; pfam02080 243090008749 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 243090008750 AIR carboxylase; Region: AIRC; smart01001 243090008751 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 243090008752 ANP binding site [chemical binding]; other site 243090008753 Substrate Binding Site II [chemical binding]; other site 243090008754 Substrate Binding Site I [chemical binding]; other site 243090008755 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090008756 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 243090008757 putative active site [active] 243090008758 dimerization interface [polypeptide binding]; other site 243090008759 putative tRNAtyr binding site [nucleotide binding]; other site 243090008760 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 243090008761 Colicin V production protein; Region: Colicin_V; pfam02674 243090008762 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 243090008763 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090008764 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090008765 active site 243090008766 ATP binding site [chemical binding]; other site 243090008767 substrate binding site [chemical binding]; other site 243090008768 activation loop (A-loop); other site 243090008769 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 243090008770 putative ADP-binding pocket [chemical binding]; other site 243090008771 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090008772 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 243090008773 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090008774 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243090008775 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090008776 DNA binding residues [nucleotide binding] 243090008777 cosmid pircos-c1g10/ cosmid pircos-c4e02 joining point 243090008778 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 243090008779 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 243090008780 FHIPEP family; Region: FHIPEP; pfam00771 243090008781 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090008782 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090008783 active site 243090008784 ATP binding site [chemical binding]; other site 243090008785 substrate binding site [chemical binding]; other site 243090008786 activation loop (A-loop); other site 243090008787 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 243090008788 generic binding surface I; other site 243090008789 generic binding surface II; other site 243090008790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243090008791 Zn2+ binding site [ion binding]; other site 243090008792 Mg2+ binding site [ion binding]; other site 243090008793 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 243090008794 Ligand Binding Site [chemical binding]; other site 243090008795 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 243090008796 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 243090008797 tetramer interface [polypeptide binding]; other site 243090008798 active site 243090008799 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 243090008800 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 243090008801 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 243090008802 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 243090008803 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 243090008804 active site 243090008805 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 243090008806 peptidase T-like protein; Region: PepT-like; TIGR01883 243090008807 metal binding site [ion binding]; metal-binding site 243090008808 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 243090008809 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 243090008810 active site residue [active] 243090008811 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090008812 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090008813 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 243090008814 GMP synthase; Reviewed; Region: guaA; PRK00074 243090008815 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 243090008816 AMP/PPi binding site [chemical binding]; other site 243090008817 candidate oxyanion hole; other site 243090008818 catalytic triad [active] 243090008819 potential glutamine specificity residues [chemical binding]; other site 243090008820 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 243090008821 ATP Binding subdomain [chemical binding]; other site 243090008822 Ligand Binding sites [chemical binding]; other site 243090008823 Dimerization subdomain; other site 243090008824 cosmid pircos-c4e02/ cosmid pircos-a3c02 joining point 243090008825 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 243090008826 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243090008827 ABC transporter; Region: ABC_tran_2; pfam12848 243090008828 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243090008829 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 243090008830 homodimer interface [polypeptide binding]; other site 243090008831 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 243090008832 active site pocket [active] 243090008833 DDE superfamily endonuclease; Region: DDE_5; pfam13546 243090008834 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243090008835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090008836 ATP binding site [chemical binding]; other site 243090008837 putative Mg++ binding site [ion binding]; other site 243090008838 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090008839 nucleotide binding region [chemical binding]; other site 243090008840 ATP-binding site [chemical binding]; other site 243090008841 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 243090008842 excinuclease ABC subunit B; Provisional; Region: PRK05298 243090008843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090008844 ATP-binding site [chemical binding]; other site 243090008845 ATP binding site [chemical binding]; other site 243090008846 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090008847 nucleotide binding region [chemical binding]; other site 243090008848 ATP-binding site [chemical binding]; other site 243090008849 Ultra-violet resistance protein B; Region: UvrB; pfam12344 243090008850 UvrB/uvrC motif; Region: UVR; pfam02151 243090008851 thymidine kinase; Provisional; Region: PRK04296 243090008852 ribonuclease R; Region: RNase_R; TIGR02063 243090008853 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 243090008854 RNB domain; Region: RNB; pfam00773 243090008855 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243090008856 RNA binding site [nucleotide binding]; other site 243090008857 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 243090008858 NAD+ binding site [chemical binding]; other site 243090008859 substrate binding site [chemical binding]; other site 243090008860 Zn binding site [ion binding]; other site 243090008861 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 243090008862 putative hydrophobic ligand binding site [chemical binding]; other site 243090008863 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 243090008864 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 243090008865 putative catalytic site [active] 243090008866 putative metal binding site [ion binding]; other site 243090008867 putative phosphate binding site [ion binding]; other site 243090008868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243090008869 non-specific DNA binding site [nucleotide binding]; other site 243090008870 salt bridge; other site 243090008871 sequence-specific DNA binding site [nucleotide binding]; other site 243090008872 primosome assembly protein PriA; Validated; Region: PRK05580 243090008873 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090008874 ATP binding site [chemical binding]; other site 243090008875 putative Mg++ binding site [ion binding]; other site 243090008876 helicase superfamily c-terminal domain; Region: HELICc; smart00490 243090008877 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090008878 Sulfatase; Region: Sulfatase; pfam00884 243090008879 HEAT repeats; Region: HEAT_2; pfam13646 243090008880 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 243090008881 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 243090008882 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243090008883 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 243090008884 cosmid pircos-a3c02/ cosmid pircos-c1e07 joining point 243090008885 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090008886 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090008887 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090008888 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090008889 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 243090008890 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 243090008891 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 243090008892 Penicillinase repressor; Region: Penicillinase_R; pfam03965 243090008893 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 243090008894 putative catalytic residue [active] 243090008895 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 243090008896 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 243090008897 active site 243090008898 (T/H)XGH motif; other site 243090008899 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 243090008900 putative active site [active] 243090008901 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 243090008902 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243090008903 active site 243090008904 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 243090008905 metal binding site 2 [ion binding]; metal-binding site 243090008906 putative DNA binding helix; other site 243090008907 metal binding site 1 [ion binding]; metal-binding site 243090008908 dimer interface [polypeptide binding]; other site 243090008909 structural Zn2+ binding site [ion binding]; other site 243090008910 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 243090008911 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 243090008912 dimer interface [polypeptide binding]; other site 243090008913 active site 243090008914 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243090008915 catalytic residues [active] 243090008916 substrate binding site [chemical binding]; other site 243090008917 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 243090008918 Na binding site [ion binding]; other site 243090008919 putative glycosylation site [posttranslational modification]; other site 243090008920 putative glycosylation site [posttranslational modification]; other site 243090008921 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 243090008922 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 243090008923 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 243090008924 YCII-related domain; Region: YCII; cl00999 243090008925 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 243090008926 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090008927 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090008928 BON domain; Region: BON; pfam04972 243090008929 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 243090008930 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090008931 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090008932 DNA binding residues [nucleotide binding] 243090008933 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 243090008934 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 243090008935 photolyase PhrII; Region: phr2; TIGR00591 243090008936 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 243090008937 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 243090008938 BNR repeat-like domain; Region: BNR_2; pfam13088 243090008939 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090008940 Trp docking motif [polypeptide binding]; other site 243090008941 active site 243090008942 PQQ-like domain; Region: PQQ_2; pfam13360 243090008943 homoserine dehydrogenase; Provisional; Region: PRK06349 243090008944 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 243090008945 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 243090008946 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 243090008947 cosmid pircos-c1e07/ cosmid pircos-a1g06 joining point 243090008948 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 243090008949 Zn binding site [ion binding]; other site 243090008950 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 243090008951 Outer membrane efflux protein; Region: OEP; pfam02321 243090008952 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243090008953 Outer membrane efflux protein; Region: OEP; pfam02321 243090008954 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 243090008955 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243090008956 AMP-binding enzyme; Region: AMP-binding; pfam00501 243090008957 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243090008958 acyl-activating enzyme (AAE) consensus motif; other site 243090008959 AMP binding site [chemical binding]; other site 243090008960 active site 243090008961 CoA binding site [chemical binding]; other site 243090008962 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090008963 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090008964 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090008965 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 243090008966 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 243090008967 intracellular protease, PfpI family; Region: PfpI; TIGR01382 243090008968 proposed catalytic triad [active] 243090008969 conserved cys residue [active] 243090008970 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 243090008971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090008972 Coenzyme A binding pocket [chemical binding]; other site 243090008973 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 243090008974 oligomer interface [polypeptide binding]; other site 243090008975 active site 243090008976 metal binding site [ion binding]; metal-binding site 243090008977 UMP-CMP kinase family; Region: UMP_CMP_kin_fam; TIGR01359 243090008978 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 243090008979 AMP-binding site [chemical binding]; other site 243090008980 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 243090008981 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 243090008982 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 243090008983 motif 1; other site 243090008984 active site 243090008985 motif 2; other site 243090008986 motif 3; other site 243090008987 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 243090008988 DHHA1 domain; Region: DHHA1; pfam02272 243090008989 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 243090008990 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 243090008991 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 243090008992 active site 243090008993 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 243090008994 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243090008995 carboxyltransferase (CT) interaction site; other site 243090008996 biotinylation site [posttranslational modification]; other site 243090008997 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 243090008998 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243090008999 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243090009000 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 243090009001 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 243090009002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243090009003 NAD(P) binding site [chemical binding]; other site 243090009004 active site 243090009005 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090009006 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090009007 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090009008 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090009009 active site 243090009010 ATP binding site [chemical binding]; other site 243090009011 substrate binding site [chemical binding]; other site 243090009012 activation loop (A-loop); other site 243090009013 Cucumber mosaic virus 1a protein family; Region: CMV_1a; pfam12467 243090009014 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 243090009015 phosphoglyceromutase; Provisional; Region: PRK05434 243090009016 cosmid pircos-a1g06/ cosmid pircos-d2d07 joining point 243090009017 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 243090009018 apolar tunnel; other site 243090009019 heme binding site [chemical binding]; other site 243090009020 dimerization interface [polypeptide binding]; other site 243090009021 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090009022 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090009023 cell division protein DamX; Validated; Region: PRK10905 243090009024 transcription termination factor Rho; Provisional; Region: PRK12678 243090009025 transcription termination factor Rho; Provisional; Region: PRK12678 243090009026 Amidinotransferase; Region: Amidinotransf; cl19186 243090009027 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 243090009028 30S subunit binding site; other site 243090009029 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 243090009030 active site 243090009031 phosphorylation site [posttranslational modification] 243090009032 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 243090009033 dimerization domain swap beta strand [polypeptide binding]; other site 243090009034 regulatory protein interface [polypeptide binding]; other site 243090009035 active site 243090009036 regulatory phosphorylation site [posttranslational modification]; other site 243090009037 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 243090009038 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 243090009039 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243090009040 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 243090009041 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 243090009042 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 243090009043 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 243090009044 homodimer interface [polypeptide binding]; other site 243090009045 oligonucleotide binding site [chemical binding]; other site 243090009046 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 243090009047 Antitermination protein; Region: Antiterm; pfam03589 243090009048 arylsulfatase; Provisional; Region: PRK13759 243090009049 Sulfatase; Region: Sulfatase; pfam00884 243090009050 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090009051 Sulfatase; Region: Sulfatase; pfam00884 243090009052 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 243090009053 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 243090009054 putative molybdopterin cofactor binding site [chemical binding]; other site 243090009055 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 243090009056 putative molybdopterin cofactor binding site; other site 243090009057 cosmid pircos-d2d07/ cosmid pircos-d3e04 joining point 243090009058 ResB-like family; Region: ResB; cl09125 243090009059 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 243090009060 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243090009061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090009062 S-adenosylmethionine binding site [chemical binding]; other site 243090009063 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 243090009064 putative active site [active] 243090009065 catalytic triad [active] 243090009066 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090009067 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090009068 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090009069 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243090009070 catalytic residues [active] 243090009071 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 243090009072 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 243090009073 putative active site [active] 243090009074 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 243090009075 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243090009076 inhibitor-cofactor binding pocket; inhibition site 243090009077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090009078 catalytic residue [active] 243090009079 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 243090009080 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 243090009081 putative active site [active] 243090009082 putative metal binding site [ion binding]; other site 243090009083 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243090009084 catalytic core [active] 243090009085 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090009086 Trp docking motif [polypeptide binding]; other site 243090009087 active site 243090009088 PQQ-like domain; Region: PQQ_2; pfam13360 243090009089 EVE domain; Region: EVE; pfam01878 243090009090 cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which...; Region: cyclophilin_ABH_like; cd01926 243090009091 active site 243090009092 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243090009093 Protein of unknown function DUF58; Region: DUF58; pfam01882 243090009094 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243090009095 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243090009096 catalytic residues [active] 243090009097 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090009098 Walker A motif; other site 243090009099 ATP binding site [chemical binding]; other site 243090009100 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243090009101 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 243090009102 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 243090009103 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243090009104 Beta-Casp domain; Region: Beta-Casp; smart01027 243090009105 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 243090009106 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 243090009107 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 243090009108 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 243090009109 active site 243090009110 Beta-lactamase; Region: Beta-lactamase; pfam00144 243090009111 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 243090009112 cosmid pircos-d3e04/ cosmid pircos-a2b07 joining point 243090009113 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 243090009114 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243090009115 Walker A/P-loop; other site 243090009116 ATP binding site [chemical binding]; other site 243090009117 Q-loop/lid; other site 243090009118 ABC transporter signature motif; other site 243090009119 Walker B; other site 243090009120 D-loop; other site 243090009121 H-loop/switch region; other site 243090009122 Predicted transcriptional regulators [Transcription]; Region: COG1725 243090009123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243090009124 DNA-binding site [nucleotide binding]; DNA binding site 243090009125 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 243090009126 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090009127 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090009128 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090009129 DNA binding residues [nucleotide binding] 243090009130 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243090009131 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243090009132 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243090009133 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090009134 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 243090009135 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090009136 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 243090009137 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090009138 Transposase IS200 like; Region: Y1_Tnp; cl00848 243090009139 Ribosomal protein L33; Region: Ribosomal_L33; pfam00471 243090009140 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 243090009141 DHH family; Region: DHH; pfam01368 243090009142 D-mannonate oxidoreductase; Provisional; Region: PRK08277 243090009143 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 243090009144 putative NAD(P) binding site [chemical binding]; other site 243090009145 active site 243090009146 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 243090009147 substrate binding site [chemical binding]; other site 243090009148 ATP binding site [chemical binding]; other site 243090009149 Domain of unknown function (DUF4430); Region: DUF4430; pfam14478 243090009150 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 243090009151 homotrimer interaction site [polypeptide binding]; other site 243090009152 active site 243090009153 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243090009154 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243090009155 phosphopeptide binding site; other site 243090009156 von Hippel-Landau (pVHL) tumor suppressor protein; Region: pVHL; cl03381 243090009157 GAF domain; Region: GAF_3; pfam13492 243090009158 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 243090009159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090009160 Walker A motif; other site 243090009161 ATP binding site [chemical binding]; other site 243090009162 Walker B motif; other site 243090009163 arginine finger; other site 243090009164 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243090009165 tellurium resistance terB-like protein; Region: terB_like; cd07177 243090009166 metal binding site [ion binding]; metal-binding site 243090009167 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 243090009168 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 243090009169 heterodimer interface [polypeptide binding]; other site 243090009170 active site 243090009171 FMN binding site [chemical binding]; other site 243090009172 homodimer interface [polypeptide binding]; other site 243090009173 substrate binding site [chemical binding]; other site 243090009174 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 243090009175 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 243090009176 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 243090009177 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 243090009178 Oxygen tolerance; Region: BatD; pfam13584 243090009179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090009180 TPR motif; other site 243090009181 TPR repeat; Region: TPR_11; pfam13414 243090009182 binding surface 243090009183 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 243090009184 von Willebrand factor type A domain; Region: VWA_2; pfam13519 243090009185 metal ion-dependent adhesion site (MIDAS); other site 243090009186 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 243090009187 Serine-rich region of AP3B1, clathrin-adaptor complex; Region: SEEEED; cl19208 243090009188 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 243090009189 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243090009190 metal ion-dependent adhesion site (MIDAS); other site 243090009191 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243090009192 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090009193 metal ion-dependent adhesion site (MIDAS); other site 243090009194 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090009195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090009196 Walker A motif; other site 243090009197 ATP binding site [chemical binding]; other site 243090009198 Walker B motif; other site 243090009199 arginine finger; other site 243090009200 SPFH domain / Band 7 family; Region: Band_7; pfam01145 243090009201 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090009202 cosmid pircos-a2b07/ cosmid pircos-c1f01 joining point 243090009203 prohibitin homologues; Region: PHB; smart00244 243090009204 SPFH domain / Band 7 family; Region: Band_7; pfam01145 243090009205 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 243090009206 transcription termination factor Rho; Provisional; Region: PRK12608 243090009207 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243090009208 RNA binding site [nucleotide binding]; other site 243090009209 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090009210 Walker A motif; other site 243090009211 ATP binding site [chemical binding]; other site 243090009212 Walker B motif; other site 243090009213 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 243090009214 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 243090009215 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 243090009216 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090009217 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090009218 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 243090009219 putative catalytic site [active] 243090009220 putative metal binding site [ion binding]; other site 243090009221 putative phosphate binding site [ion binding]; other site 243090009222 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 243090009223 hexamer (dimer of trimers) interface [polypeptide binding]; other site 243090009224 substrate binding site [chemical binding]; other site 243090009225 trimer interface [polypeptide binding]; other site 243090009226 Mn binding site [ion binding]; other site 243090009227 ribulokinase; Provisional; Region: PRK04123 243090009228 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 243090009229 N- and C-terminal domain interface [polypeptide binding]; other site 243090009230 active site 243090009231 MgATP binding site [chemical binding]; other site 243090009232 catalytic site [active] 243090009233 metal binding site [ion binding]; metal-binding site 243090009234 carbohydrate binding site [chemical binding]; other site 243090009235 homodimer interface [polypeptide binding]; other site 243090009236 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090009237 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090009238 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090009239 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 243090009240 Transcriptional regulators [Transcription]; Region: GntR; COG1802 243090009241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 243090009242 DNA-binding site [nucleotide binding]; DNA binding site 243090009243 FCD domain; Region: FCD; pfam07729 243090009244 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 243090009245 Na binding site [ion binding]; other site 243090009246 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 243090009247 inhibitor site; inhibition site 243090009248 active site 243090009249 dimer interface [polypeptide binding]; other site 243090009250 catalytic residue [active] 243090009251 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090009252 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090009253 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 243090009254 active site 243090009255 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 243090009256 Protein of unknown function (DUF502); Region: DUF502; cl01107 243090009257 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 243090009258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243090009259 active site 243090009260 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 243090009261 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090009262 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090009263 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 243090009264 DNA binding residues [nucleotide binding] 243090009265 Global regulator protein family; Region: CsrA; pfam02599 243090009266 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090009267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090009268 active site 243090009269 phosphorylation site [posttranslational modification] 243090009270 intermolecular recognition site; other site 243090009271 dimerization interface [polypeptide binding]; other site 243090009272 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 243090009273 cosmid pircos-c1f01/ cosmid pircos-a4a07 joining point 243090009274 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 243090009275 nucleoside/Zn binding site; other site 243090009276 dimer interface [polypeptide binding]; other site 243090009277 catalytic motif [active] 243090009278 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 243090009279 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 243090009280 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 243090009281 active site 243090009282 substrate binding site [chemical binding]; other site 243090009283 ATP binding site [chemical binding]; other site 243090009284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243090009285 dimer interface [polypeptide binding]; other site 243090009286 conserved gate region; other site 243090009287 ABC-ATPase subunit interface; other site 243090009288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243090009289 dimer interface [polypeptide binding]; other site 243090009290 conserved gate region; other site 243090009291 putative PBP binding loops; other site 243090009292 ABC-ATPase subunit interface; other site 243090009293 ZIP Zinc transporter; Region: Zip; cl00437 243090009294 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 243090009295 PhoD-like phosphatase; Region: PhoD; pfam09423 243090009296 Fibronectin type III domain; Region: fn3; pfam00041 243090009297 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 243090009298 putative active site [active] 243090009299 putative metal binding site [ion binding]; other site 243090009300 Sulfatase; Region: Sulfatase; cl19157 243090009301 Acylphosphatase; Region: Acylphosphatase; pfam00708 243090009302 DNA gyrase subunit A; Validated; Region: PRK05560 243090009303 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 243090009304 CAP-like domain; other site 243090009305 active site 243090009306 primary dimer interface [polypeptide binding]; other site 243090009307 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243090009308 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243090009309 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243090009310 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243090009311 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243090009312 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243090009313 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 243090009314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090009315 Walker A motif; other site 243090009316 ATP binding site [chemical binding]; other site 243090009317 Walker B motif; other site 243090009318 arginine finger; other site 243090009319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090009320 S-adenosylmethionine binding site [chemical binding]; other site 243090009321 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 243090009322 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 243090009323 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 243090009324 chalcone synthase; Provisional; Region: PLN03168 243090009325 malonyl-CoA binding site [chemical binding]; other site 243090009326 dimer interface [polypeptide binding]; other site 243090009327 active site 243090009328 product binding site; other site 243090009329 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 243090009330 Pleckstrin homology-like domain; Region: PH-like; cl17171 243090009331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090009332 S-adenosylmethionine binding site [chemical binding]; other site 243090009333 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 243090009334 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 243090009335 putative ligand binding site [chemical binding]; other site 243090009336 putative NAD binding site [chemical binding]; other site 243090009337 catalytic site [active] 243090009338 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 243090009339 Domain of unknown function DUF59; Region: DUF59; cl00941 243090009340 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 243090009341 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 243090009342 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243090009343 classical (c) SDRs; Region: SDR_c; cd05233 243090009344 NAD(P) binding site [chemical binding]; other site 243090009345 active site 243090009346 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 243090009347 amphipathic channel; other site 243090009348 Asn-Pro-Ala signature motifs; other site 243090009349 CHASE3 domain; Region: CHASE3; pfam05227 243090009350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090009351 putative active site [active] 243090009352 PAS fold; Region: PAS_3; pfam08447 243090009353 heme pocket [chemical binding]; other site 243090009354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090009355 dimer interface [polypeptide binding]; other site 243090009356 phosphorylation site [posttranslational modification] 243090009357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090009358 ATP binding site [chemical binding]; other site 243090009359 Mg2+ binding site [ion binding]; other site 243090009360 G-X-G motif; other site 243090009361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090009362 active site 243090009363 phosphorylation site [posttranslational modification] 243090009364 intermolecular recognition site; other site 243090009365 dimerization interface [polypeptide binding]; other site 243090009366 cosmid pircos-a4a07/ cosmid pircos-b1d02 joining point 243090009367 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 243090009368 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090009369 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090009370 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090009371 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 243090009372 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 243090009373 PhoD-like phosphatase; Region: PhoD; pfam09423 243090009374 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 243090009375 putative active site [active] 243090009376 putative metal binding site [ion binding]; other site 243090009377 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 243090009378 active site 243090009379 catalytic triad [active] 243090009380 oxyanion hole [active] 243090009381 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090009382 HEAT repeats; Region: HEAT_2; pfam13646 243090009383 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243090009384 Cytochrome c; Region: Cytochrom_C; pfam00034 243090009385 Cytochrome c; Region: Cytochrom_C; cl11414 243090009386 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 243090009387 catalytic site [active] 243090009388 BNR repeat-like domain; Region: BNR_2; pfam13088 243090009389 Asp-box motif; other site 243090009390 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 243090009391 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 243090009392 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090009393 NAD binding site [chemical binding]; other site 243090009394 homotetramer interface [polypeptide binding]; other site 243090009395 homodimer interface [polypeptide binding]; other site 243090009396 active site 243090009397 substrate binding site [chemical binding]; other site 243090009398 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243090009399 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 243090009400 Ligand binding site; other site 243090009401 Putative Catalytic site; other site 243090009402 DXD motif; other site 243090009403 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 243090009404 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 243090009405 PhoU domain; Region: PhoU; pfam01895 243090009406 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 243090009407 active site 243090009408 putative acetyltransferase; Provisional; Region: PRK03624 243090009409 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 243090009410 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243090009411 active site 243090009412 HIGH motif; other site 243090009413 nucleotide binding site [chemical binding]; other site 243090009414 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243090009415 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243090009416 active site 243090009417 KMSKS motif; other site 243090009418 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 243090009419 tRNA binding surface [nucleotide binding]; other site 243090009420 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243090009421 proposed homoserine kinase; Region: hyp_Hser_kinase; TIGR02535 243090009422 aspartate kinase; Provisional; Region: PRK07431 243090009423 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 243090009424 putative nucleotide binding site [chemical binding]; other site 243090009425 putative catalytic residues [active] 243090009426 putative Mg ion binding site [ion binding]; other site 243090009427 putative aspartate binding site [chemical binding]; other site 243090009428 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 243090009429 putative allosteric regulatory site; other site 243090009430 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 243090009431 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 243090009432 putative allosteric regulatory site; other site 243090009433 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 243090009434 putative allosteric regulatory residue; other site 243090009435 cosmid pircos-b1d02/ cosmid pircos-b1e11 joining point 243090009436 Cytochrome c; Region: Cytochrom_C; pfam00034 243090009437 Cytochrome c; Region: Cytochrom_C; pfam00034 243090009438 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243090009439 putative acyl-acceptor binding pocket; other site 243090009440 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090009441 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090009442 active site 243090009443 ATP binding site [chemical binding]; other site 243090009444 substrate binding site [chemical binding]; other site 243090009445 activation loop (A-loop); other site 243090009446 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 243090009447 FAD dependent oxidoreductase; Region: DAO; pfam01266 243090009448 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090009449 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 243090009450 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090009451 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243090009452 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 243090009453 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 243090009454 active site residue [active] 243090009455 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243090009456 dimerization interface [polypeptide binding]; other site 243090009457 putative DNA binding site [nucleotide binding]; other site 243090009458 putative Zn2+ binding site [ion binding]; other site 243090009459 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 243090009460 dimer interface [polypeptide binding]; other site 243090009461 NADP binding site [chemical binding]; other site 243090009462 catalytic residues [active] 243090009463 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090009464 large tegument protein UL36; Provisional; Region: PHA03247 243090009465 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 243090009466 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 243090009467 ring oligomerisation interface [polypeptide binding]; other site 243090009468 ATP/Mg binding site [chemical binding]; other site 243090009469 stacking interactions; other site 243090009470 hinge regions; other site 243090009471 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 243090009472 oligomerisation interface [polypeptide binding]; other site 243090009473 mobile loop; other site 243090009474 roof hairpin; other site 243090009475 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 243090009476 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 243090009477 ring oligomerisation interface [polypeptide binding]; other site 243090009478 ATP/Mg binding site [chemical binding]; other site 243090009479 stacking interactions; other site 243090009480 hinge regions; other site 243090009481 chaperone protein DnaJ; Provisional; Region: PRK10767 243090009482 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243090009483 HSP70 interaction site [polypeptide binding]; other site 243090009484 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 243090009485 substrate binding site [polypeptide binding]; other site 243090009486 dimer interface [polypeptide binding]; other site 243090009487 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 243090009488 dimer interface [polypeptide binding]; other site 243090009489 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 243090009490 Zinc ribbon domain; Region: Zn-ribbon_8; cl00993 243090009491 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 243090009492 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 243090009493 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 243090009494 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 243090009495 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090009496 cosmid pircos-b1e11/ cosmid pircos-a4c09 joining point 243090009497 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090009498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090009499 Walker A motif; other site 243090009500 ATP binding site [chemical binding]; other site 243090009501 Walker B motif; other site 243090009502 arginine finger; other site 243090009503 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 243090009504 putative active site [active] 243090009505 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243090009506 Protein of unknown function DUF58; Region: DUF58; pfam01882 243090009507 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090009508 metal ion-dependent adhesion site (MIDAS); other site 243090009509 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 243090009510 von Willebrand factor type A domain; Region: VWA_2; pfam13519 243090009511 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 243090009512 Filamin/ABP280 repeat; Region: Filamin; cl19759 243090009513 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 243090009514 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090009515 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090009516 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243090009517 catalytic residues [active] 243090009518 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090009519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090009520 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090009521 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090009522 active site 243090009523 ATP binding site [chemical binding]; other site 243090009524 substrate binding site [chemical binding]; other site 243090009525 activation loop (A-loop); other site 243090009526 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 243090009527 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090009528 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090009529 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 243090009530 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 243090009531 active site 243090009532 Zn binding site [ion binding]; other site 243090009533 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 243090009534 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 243090009535 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090009536 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090009537 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090009538 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090009539 cosmid pircos-a4c09/ cosmid pircos-d3c01 joining point 243090009540 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 243090009541 Domain of unknown function DUF11; Region: DUF11; cl17728 243090009542 Domain of unknown function DUF11; Region: DUF11; pfam01345 243090009543 Domain of unknown function DUF11; Region: DUF11; pfam01345 243090009544 Domain of unknown function DUF11; Region: DUF11; pfam01345 243090009545 Cna protein B-type domain; Region: Cna_B; pfam05738 243090009546 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 243090009547 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243090009548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090009549 TPR motif; other site 243090009550 binding surface 243090009551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090009552 binding surface 243090009553 TPR motif; other site 243090009554 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090009555 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090009556 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090009557 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090009558 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 243090009559 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090009560 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090009561 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090009562 TPR repeat; Region: TPR_11; pfam13414 243090009563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090009564 binding surface 243090009565 TPR motif; other site 243090009566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090009567 binding surface 243090009568 TPR motif; other site 243090009569 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090009570 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090009571 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 243090009572 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 243090009573 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243090009574 ABC transporter; Region: ABC_tran_2; pfam12848 243090009575 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243090009576 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 243090009577 StbA protein; Region: StbA; cl19281 243090009578 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 243090009579 TPP-binding site [chemical binding]; other site 243090009580 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 243090009581 dimer interface [polypeptide binding]; other site 243090009582 PYR/PP interface [polypeptide binding]; other site 243090009583 TPP binding site [chemical binding]; other site 243090009584 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 243090009585 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243090009586 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 243090009587 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 243090009588 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 243090009589 UGMP family protein; Validated; Region: PRK09604 243090009590 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 243090009591 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 243090009592 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 243090009593 putative active site [active] 243090009594 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 243090009595 oligomerization interface [polypeptide binding]; other site 243090009596 active site 243090009597 metal binding site [ion binding]; metal-binding site 243090009598 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090009599 Sulfatase; Region: Sulfatase; pfam00884 243090009600 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243090009601 active site 243090009602 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243090009603 cosmid pircos-d3c01/ cosmid pircos-a2h12 joining point 243090009604 YceI-like domain; Region: YceI; pfam04264 243090009605 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 243090009606 Clp amino terminal domain; Region: Clp_N; pfam02861 243090009607 Clp amino terminal domain; Region: Clp_N; pfam02861 243090009608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090009609 Walker A motif; other site 243090009610 ATP binding site [chemical binding]; other site 243090009611 Walker B motif; other site 243090009612 arginine finger; other site 243090009613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090009614 Walker A motif; other site 243090009615 ATP binding site [chemical binding]; other site 243090009616 Walker B motif; other site 243090009617 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 243090009618 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 243090009619 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 243090009620 nucleotide binding site [chemical binding]; other site 243090009621 NEF interaction site [polypeptide binding]; other site 243090009622 SBD interface [polypeptide binding]; other site 243090009623 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 243090009624 Prephenate dehydratase; Region: PDT; pfam00800 243090009625 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 243090009626 putative L-Phe binding site [chemical binding]; other site 243090009627 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090009628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090009629 Walker A motif; other site 243090009630 ATP binding site [chemical binding]; other site 243090009631 Walker B motif; other site 243090009632 arginine finger; other site 243090009633 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 243090009634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090009635 ATP binding site [chemical binding]; other site 243090009636 Mg2+ binding site [ion binding]; other site 243090009637 G-X-G motif; other site 243090009638 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 243090009639 anchoring element; other site 243090009640 dimer interface [polypeptide binding]; other site 243090009641 ATP binding site [chemical binding]; other site 243090009642 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 243090009643 active site 243090009644 putative metal-binding site [ion binding]; other site 243090009645 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 243090009646 PQQ-like domain; Region: PQQ_2; pfam13360 243090009647 PQQ-like domain; Region: PQQ_2; pfam13360 243090009648 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090009649 active site 243090009650 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 243090009651 intracellular protease, PfpI family; Region: PfpI; TIGR01382 243090009652 conserved cys residue [active] 243090009653 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243090009654 metal ion-dependent adhesion site (MIDAS); other site 243090009655 hypothetical protein; Reviewed; Region: PRK12497 243090009656 acetylornithine deacetylase; Provisional; Region: PRK07522 243090009657 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 243090009658 metal binding site [ion binding]; metal-binding site 243090009659 putative dimer interface [polypeptide binding]; other site 243090009660 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 243090009661 MgtE intracellular N domain; Region: MgtE_N; pfam03448 243090009662 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 243090009663 Divalent cation transporter; Region: MgtE; pfam01769 243090009664 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 243090009665 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090009666 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 243090009667 HEAT repeats; Region: HEAT_2; pfam13646 243090009668 Cytochrome c; Region: Cytochrom_C; cl11414 243090009669 hypothetical protein; Provisional; Region: PRK00944 243090009670 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090009671 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090009672 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 243090009673 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 243090009674 substrate binding site; other site 243090009675 dimer interface; other site 243090009676 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 243090009677 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 243090009678 active site 243090009679 HIGH motif; other site 243090009680 dimer interface [polypeptide binding]; other site 243090009681 KMSKS motif; other site 243090009682 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243090009683 RNA binding surface [nucleotide binding]; other site 243090009684 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090009685 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 243090009686 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 243090009687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090009688 S-adenosylmethionine binding site [chemical binding]; other site 243090009689 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 243090009690 Bacterial transcriptional activator domain; Region: BTAD; smart01043 243090009691 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090009692 binding surface 243090009693 TPR motif; other site 243090009694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090009695 TPR repeat; Region: TPR_11; pfam13414 243090009696 binding surface 243090009697 TPR motif; other site 243090009698 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090009699 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090009700 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 243090009701 cosmid pircos-a2h12/ cosmid pircos-c3c01 joining point 243090009702 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090009703 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090009704 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 243090009705 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 243090009706 putative catalytic residue [active] 243090009707 Haem-binding domain; Region: Haem_bd; pfam14376 243090009708 Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082 243090009709 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 243090009710 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090009711 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 243090009712 putative NAD(P) binding site [chemical binding]; other site 243090009713 active site 243090009714 putative substrate binding site [chemical binding]; other site 243090009715 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 243090009716 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 243090009717 active site 243090009718 homodimer interface [polypeptide binding]; other site 243090009719 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090009720 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090009721 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090009722 envelope glycoprotein C; Provisional; Region: PHA03269 243090009723 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243090009724 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 243090009725 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243090009726 SLBB domain; Region: SLBB; pfam10531 243090009727 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 243090009728 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 243090009729 active site 243090009730 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243090009731 substrate binding site [chemical binding]; other site 243090009732 catalytic residues [active] 243090009733 dimer interface [polypeptide binding]; other site 243090009734 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243090009735 catalytic loop [active] 243090009736 iron binding site [ion binding]; other site 243090009737 Protein of unknown function (DUF1586); Region: DUF1586; pfam07625 243090009738 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090009739 Sulfatase; Region: Sulfatase; pfam00884 243090009740 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090009741 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090009742 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 243090009743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243090009744 active site 243090009745 motif I; other site 243090009746 motif II; other site 243090009747 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 243090009748 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 243090009749 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 243090009750 MG2 domain; Region: A2M_N; pfam01835 243090009751 MG2 domain; Region: A2M_N; cl19929 243090009752 Alpha-2-macroglobulin family; Region: A2M; pfam00207 243090009753 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 243090009754 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243090009755 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 243090009756 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243090009757 catalytic residue [active] 243090009758 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 243090009759 putative catalytic site [active] 243090009760 putative metal binding site [ion binding]; other site 243090009761 putative phosphate binding site [ion binding]; other site 243090009762 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 243090009763 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243090009764 E3 interaction surface; other site 243090009765 lipoyl attachment site [posttranslational modification]; other site 243090009766 e3 binding domain; Region: E3_binding; pfam02817 243090009767 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243090009768 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 243090009769 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243090009770 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243090009771 Uncharacterized conserved protein [Function unknown]; Region: COG0062 243090009772 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 243090009773 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 243090009774 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090009775 protein binding site [polypeptide binding]; other site 243090009776 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 243090009777 active site 243090009778 ATP binding site [chemical binding]; other site 243090009779 cosmid pircos-c3c01/ cosmid pircos-c2g12 joining point 243090009780 Helix-turn-helix domain; Region: HTH_36; pfam13730 243090009781 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 243090009782 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 243090009783 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243090009784 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 243090009785 Substrate binding site; other site 243090009786 metal-binding site 243090009787 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 243090009788 GDP-Fucose binding site [chemical binding]; other site 243090009789 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 243090009790 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 243090009791 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243090009792 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA); Region: CgtA; pfam06306 243090009793 active site 243090009794 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 243090009795 Domain of Unknown Function (DUF959); Region: DUF959; pfam06121 243090009796 DNA polymerase alpha subunit B N-terminal; Region: Pol_alpha_B_N; pfam08418 243090009797 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 243090009798 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 243090009799 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 243090009800 FtsJ-like methyltransferase; Region: FtsJ; cl17430 243090009801 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090009802 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090009803 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243090009804 acyl-activating enzyme (AAE) consensus motif; other site 243090009805 active site 243090009806 AMP binding site [chemical binding]; other site 243090009807 CoA binding site [chemical binding]; other site 243090009808 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243090009809 NAD(P) binding site [chemical binding]; other site 243090009810 catalytic residues [active] 243090009811 Flagellar protein (FlbD); Region: FlbD; pfam06289 243090009812 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 243090009813 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 243090009814 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 243090009815 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243090009816 ligand binding site [chemical binding]; other site 243090009817 flagellar motor switch protein FliN; Region: fliN; TIGR02480 243090009818 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 243090009819 photolyase PhrII; Region: phr2; TIGR00591 243090009820 DNA photolyase; Region: DNA_photolyase; pfam00875 243090009821 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 243090009822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090009823 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243090009824 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 243090009825 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 243090009826 active site lid residues [active] 243090009827 catalytic residues [active] 243090009828 substrate binding pocket [chemical binding]; other site 243090009829 substrate-Mg2+ binding site; other site 243090009830 aspartate-rich region 1; other site 243090009831 aspartate-rich region 2; other site 243090009832 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 243090009833 active site lid residues [active] 243090009834 substrate binding pocket [chemical binding]; other site 243090009835 catalytic residues [active] 243090009836 substrate-Mg2+ binding site; other site 243090009837 aspartate-rich region 1; other site 243090009838 aspartate-rich region 2; other site 243090009839 cosmid pircos-c2g12/ cosmid pircos-a2a12 joining point 243090009840 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 243090009841 Fe-S cluster binding site [ion binding]; other site 243090009842 substrate binding site [chemical binding]; other site 243090009843 catalytic site [active] 243090009844 Bacterial transcriptional activator domain; Region: BTAD; smart01043 243090009845 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090009846 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090009847 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090009848 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 243090009849 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 243090009850 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 243090009851 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 243090009852 active site 243090009853 catalytic site [active] 243090009854 Protein of unknown function (DUF805); Region: DUF805; pfam05656 243090009855 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090009856 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090009857 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090009858 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 243090009859 peptide chain release factor 1; Validated; Region: prfA; PRK00591 243090009860 PCRF domain; Region: PCRF; pfam03462 243090009861 RF-1 domain; Region: RF-1; pfam00472 243090009862 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 243090009863 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243090009864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090009865 S-adenosylmethionine binding site [chemical binding]; other site 243090009866 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243090009867 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243090009868 Outer membrane efflux protein; Region: OEP; pfam02321 243090009869 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090009870 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090009871 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243090009872 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090009873 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 243090009874 Peptidase family M50; Region: Peptidase_M50; pfam02163 243090009875 active site 243090009876 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090009877 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090009878 Laminin Domain II; Region: Laminin_II; pfam06009 243090009879 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090009880 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090009881 active site 243090009882 ATP binding site [chemical binding]; other site 243090009883 substrate binding site [chemical binding]; other site 243090009884 activation loop (A-loop); other site 243090009885 Septum formation initiator; Region: DivIC; cl17659 243090009886 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 243090009887 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090009888 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090009889 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090009890 structural tetrad; other site 243090009891 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090009892 structural tetrad; other site 243090009893 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090009894 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090009895 structural tetrad; other site 243090009896 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 243090009897 active site 243090009898 catalytic site [active] 243090009899 substrate binding site [chemical binding]; other site 243090009900 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 243090009901 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 243090009902 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090009903 structural tetrad; other site 243090009904 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090009905 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090009906 Cna protein B-type domain; Region: Cna_B; pfam05738 243090009907 Cna protein B-type domain; Region: Cna_B; pfam05738 243090009908 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090009909 Cna protein B-type domain; Region: Cna_B; pfam05738 243090009910 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090009911 Cna protein B-type domain; Region: Cna_B; pfam05738 243090009912 Cna protein B-type domain; Region: Cna_B; pfam05738 243090009913 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090009914 Cna protein B-type domain; Region: Cna_B; pfam05738 243090009915 cosmid pircos-a2a12/ cosmid gap joining point 243090009916 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 243090009917 HEAT repeats; Region: HEAT_2; pfam13646 243090009918 HEAT repeats; Region: HEAT_2; pfam13646 243090009919 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 243090009920 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090009921 ATP binding site [chemical binding]; other site 243090009922 putative Mg++ binding site [ion binding]; other site 243090009923 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090009924 nucleotide binding region [chemical binding]; other site 243090009925 ATP-binding site [chemical binding]; other site 243090009926 PSRT; Region: PSRT; pfam07636 243090009927 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243090009928 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 243090009929 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 243090009930 DNA binding residues [nucleotide binding] 243090009931 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 243090009932 GIY-YIG motif/motif A; other site 243090009933 active site 243090009934 catalytic site [active] 243090009935 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 243090009936 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 243090009937 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 243090009938 putative active site [active] 243090009939 adenylation catalytic residue [active] 243090009940 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 243090009941 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 243090009942 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 243090009943 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 243090009944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090009945 Walker A motif; other site 243090009946 ATP binding site [chemical binding]; other site 243090009947 Walker B motif; other site 243090009948 arginine finger; other site 243090009949 Sodium Bile acid symporter family; Region: SBF; cl19217 243090009950 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090009951 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090009952 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 243090009953 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 243090009954 putative active site [active] 243090009955 oxyanion strand; other site 243090009956 catalytic triad [active] 243090009957 cosmid gap/ cosmid pircos-a3g04 joining point 243090009958 DEAD-like helicases superfamily; Region: DEXDc; smart00487 243090009959 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090009960 ATP binding site [chemical binding]; other site 243090009961 putative Mg++ binding site [ion binding]; other site 243090009962 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090009963 nucleotide binding region [chemical binding]; other site 243090009964 ATP-binding site [chemical binding]; other site 243090009965 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090009966 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090009967 Ca2+ binding site [ion binding]; other site 243090009968 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090009969 Ca2+ binding site [ion binding]; other site 243090009970 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090009971 Ca2+ binding site [ion binding]; other site 243090009972 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 243090009973 Ca2+ binding site [ion binding]; other site 243090009974 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090009975 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090009976 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 243090009977 TM-ABC transporter signature motif; other site 243090009978 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 243090009979 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 243090009980 Walker A/P-loop; other site 243090009981 ATP binding site [chemical binding]; other site 243090009982 Q-loop/lid; other site 243090009983 ABC transporter signature motif; other site 243090009984 Walker B; other site 243090009985 D-loop; other site 243090009986 H-loop/switch region; other site 243090009987 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 243090009988 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243090009989 catalytic residues [active] 243090009990 type II secretion system protein D; Region: type_II_gspD; TIGR02517 243090009991 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090009992 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090009993 MMPL family; Region: MMPL; cl14618 243090009994 MMPL family; Region: MMPL; cl14618 243090009995 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 243090009996 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 243090009997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090009998 FeS/SAM binding site; other site 243090009999 TRAM domain; Region: TRAM; cl01282 243090010000 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 243090010001 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 243090010002 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 243090010003 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 243090010004 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 243090010005 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 243090010006 TraB family; Region: TraB; cl12050 243090010007 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243090010008 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 243090010009 CHASE domain; Region: CHASE; pfam03924 243090010010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090010011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090010012 putative active site [active] 243090010013 heme pocket [chemical binding]; other site 243090010014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090010015 dimer interface [polypeptide binding]; other site 243090010016 phosphorylation site [posttranslational modification] 243090010017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090010018 ATP binding site [chemical binding]; other site 243090010019 Mg2+ binding site [ion binding]; other site 243090010020 G-X-G motif; other site 243090010021 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 243090010022 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243090010023 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 243090010024 Walker A/P-loop; other site 243090010025 ATP binding site [chemical binding]; other site 243090010026 Q-loop/lid; other site 243090010027 ABC transporter signature motif; other site 243090010028 Walker B; other site 243090010029 D-loop; other site 243090010030 H-loop/switch region; other site 243090010031 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090010032 metal ion-dependent adhesion site (MIDAS); other site 243090010033 Protein of unknown function DUF58; Region: DUF58; pfam01882 243090010034 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090010035 metal ion-dependent adhesion site (MIDAS); other site 243090010036 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 243090010037 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243090010038 metal ion-dependent adhesion site (MIDAS); other site 243090010039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090010040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090010041 dimer interface [polypeptide binding]; other site 243090010042 phosphorylation site [posttranslational modification] 243090010043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090010044 ATP binding site [chemical binding]; other site 243090010045 Mg2+ binding site [ion binding]; other site 243090010046 G-X-G motif; other site 243090010047 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090010048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090010049 active site 243090010050 phosphorylation site [posttranslational modification] 243090010051 intermolecular recognition site; other site 243090010052 dimerization interface [polypeptide binding]; other site 243090010053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243090010054 DNA binding site [nucleotide binding] 243090010055 Methylamine utilization protein MauL; Region: MauL; cd04221 243090010056 putative Type 1 (T1) Cu binding site [ion binding]; other site 243090010057 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 243090010058 putative active site [active] 243090010059 Protein kinase domain; Region: Pkinase; pfam00069 243090010060 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090010061 active site 243090010062 ATP binding site [chemical binding]; other site 243090010063 substrate binding site [chemical binding]; other site 243090010064 activation loop (A-loop); other site 243090010065 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090010066 cosmid pircos-a3g04/ cosmid pircos-d1h06 joining point 243090010067 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090010068 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090010069 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090010070 Histone deacetylase complex subunit SAP25; Region: SAP25; pfam15476 243090010071 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090010072 Cytochrome c; Region: Cytochrom_C; pfam00034 243090010073 Cytochrome c; Region: Cytochrom_C; cl11414 243090010074 PA14 domain; Region: PA14; pfam07691 243090010075 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 243090010076 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243090010077 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 243090010078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090010079 Coenzyme A binding pocket [chemical binding]; other site 243090010080 Tic20-like protein; Region: Tic20; pfam09685 243090010081 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 243090010082 ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; Region: RPT1; COG1222 243090010083 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090010084 polyphosphate kinase; Provisional; Region: PRK05443 243090010085 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 243090010086 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 243090010087 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 243090010088 putative domain interface [polypeptide binding]; other site 243090010089 putative active site [active] 243090010090 catalytic site [active] 243090010091 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 243090010092 putative domain interface [polypeptide binding]; other site 243090010093 putative active site [active] 243090010094 catalytic site [active] 243090010095 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243090010096 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243090010097 Walker A/P-loop; other site 243090010098 ATP binding site [chemical binding]; other site 243090010099 Q-loop/lid; other site 243090010100 ABC transporter signature motif; other site 243090010101 Walker B; other site 243090010102 D-loop; other site 243090010103 H-loop/switch region; other site 243090010104 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 243090010105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090010106 S-adenosylmethionine binding site [chemical binding]; other site 243090010107 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090010108 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 243090010109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 243090010110 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 243090010111 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243090010112 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243090010113 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 243090010114 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 243090010115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090010116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243090010117 Coenzyme A binding pocket [chemical binding]; other site 243090010118 cosmid pircos-d1h06/ cosmid pircos-c3c05 joining point 243090010119 Pirin-related protein [General function prediction only]; Region: COG1741 243090010120 Pirin; Region: Pirin; pfam02678 243090010121 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 243090010122 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090010123 Sulfatase; Region: Sulfatase; pfam00884 243090010124 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090010125 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090010126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090010127 Walker A motif; other site 243090010128 ATP binding site [chemical binding]; other site 243090010129 Walker B motif; other site 243090010130 arginine finger; other site 243090010131 Protein of unknown function DUF58; Region: DUF58; pfam01882 243090010132 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 243090010133 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 243090010134 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 243090010135 metal ion-dependent adhesion site (MIDAS); other site 243090010136 von Willebrand factor type A domain; Region: VWA_2; pfam13519 243090010137 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243090010138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090010139 TPR motif; other site 243090010140 binding surface 243090010141 Oxygen tolerance; Region: BatD; pfam13584 243090010142 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 243090010143 SnoaL-like domain; Region: SnoaL_2; pfam12680 243090010144 African swine fever virus J13L protein; Region: ASFV_J13L; pfam05568 243090010145 SLA1 homology domain 1, SHD1; Region: SHD1; pfam03983 243090010146 Porin subfamily; Region: Porin_2; pfam02530 243090010147 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 243090010148 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 243090010149 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090010150 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243090010151 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090010152 Sulfatase; Region: Sulfatase; pfam00884 243090010153 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090010154 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 243090010155 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 243090010156 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 243090010157 putative active site [active] 243090010158 catalytic site [active] 243090010159 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 243090010160 putative active site [active] 243090010161 catalytic site [active] 243090010162 Amino acid permease; Region: AA_permease_2; pfam13520 243090010163 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 243090010164 Ion channel; Region: Ion_trans_2; pfam07885 243090010165 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090010166 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090010167 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090010168 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 243090010169 MMPL family; Region: MMPL; cl14618 243090010170 MMPL family; Region: MMPL; cl14618 243090010171 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243090010172 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090010173 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243090010174 putative hydrolase; Provisional; Region: PRK11460 243090010175 arylsulfatase; Provisional; Region: PRK13759 243090010176 Sulfatase; Region: Sulfatase; pfam00884 243090010177 von Hippel-Landau (pVHL) tumor suppressor protein; Region: pVHL; cd05468 243090010178 pVHL-HIF-1alpha interaction [polypeptide binding]; other site 243090010179 pVHL-ElonginB-ElonginC (VBC) interface [polypeptide binding]; other site 243090010180 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090010181 Sulfatase; Region: Sulfatase; pfam00884 243090010182 cosmid pircos-c3c05/ cosmid pircos-b1c07 joining point 243090010183 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 243090010184 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 243090010185 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 243090010186 P loop; other site 243090010187 Nucleotide binding site [chemical binding]; other site 243090010188 DTAP/Switch II; other site 243090010189 Switch I; other site 243090010190 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 243090010191 P loop; other site 243090010192 Nucleotide binding site [chemical binding]; other site 243090010193 DTAP/Switch II; other site 243090010194 Switch I; other site 243090010195 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 243090010196 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 243090010197 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090010198 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090010199 DNA binding residues [nucleotide binding] 243090010200 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 243090010201 FecR protein; Region: FecR; pfam04773 243090010202 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243090010203 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243090010204 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 243090010205 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 243090010206 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243090010207 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 243090010208 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 243090010209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090010210 Walker A motif; other site 243090010211 ATP binding site [chemical binding]; other site 243090010212 Walker B motif; other site 243090010213 arginine finger; other site 243090010214 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243090010215 cosmid pircos-b1c07/ cosmid pircos-a4f06 joining point 243090010216 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 243090010217 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090010218 HEAT repeats; Region: HEAT_2; pfam13646 243090010219 Cytochrome c; Region: Cytochrom_C; cl11414 243090010220 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243090010221 classical (c) SDRs; Region: SDR_c; cd05233 243090010222 NAD(P) binding site [chemical binding]; other site 243090010223 active site 243090010224 Predicted transcriptional regulators [Transcription]; Region: COG1733 243090010225 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243090010226 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 243090010227 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 243090010228 putative NAD(P) binding site [chemical binding]; other site 243090010229 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 243090010230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243090010231 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 243090010232 NAD(P) binding site [chemical binding]; other site 243090010233 active site 243090010234 SWIM zinc finger; Region: SWIM; cl19527 243090010235 Uncharacterized conserved protein [Function unknown]; Region: COG4715 243090010236 TIGR02452 family protein; Region: TIGR02452 243090010237 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 243090010238 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 243090010239 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090010240 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090010241 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090010242 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 243090010243 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090010244 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090010245 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090010246 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090010247 structural tetrad; other site 243090010248 SLA1 homology domain 1, SHD1; Region: SHD1; pfam03983 243090010249 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 243090010250 Male sterility protein; Region: NAD_binding_4; pfam07993 243090010251 putative NAD(P) binding site [chemical binding]; other site 243090010252 active site 243090010253 putative substrate binding site [chemical binding]; other site 243090010254 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 243090010255 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243090010256 Walker A/P-loop; other site 243090010257 ATP binding site [chemical binding]; other site 243090010258 Q-loop/lid; other site 243090010259 ABC transporter signature motif; other site 243090010260 Walker B; other site 243090010261 D-loop; other site 243090010262 H-loop/switch region; other site 243090010263 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243090010264 FtsX-like permease family; Region: FtsX; pfam02687 243090010265 cosmid pircos-a4f06/ cosmid pircos-d3e08 joining point 243090010266 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 243090010267 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243090010268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243090010269 Walker A/P-loop; other site 243090010270 ATP binding site [chemical binding]; other site 243090010271 Q-loop/lid; other site 243090010272 ABC transporter signature motif; other site 243090010273 Walker B; other site 243090010274 D-loop; other site 243090010275 H-loop/switch region; other site 243090010276 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 243090010277 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 243090010278 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 243090010279 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090010280 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 243090010281 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243090010282 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243090010283 active site 243090010284 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 243090010285 active site 243090010286 metal-binding site [ion binding] 243090010287 nucleotide-binding site [chemical binding]; other site 243090010288 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 243090010289 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090010290 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090010291 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 243090010292 Di-iron ligands [ion binding]; other site 243090010293 Condensation domain; Region: Condensation; cl19241 243090010294 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 243090010295 cosmid pircos-d3e08/ cosmid pircos-c4f11 joining point 243090010296 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243090010297 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243090010298 active site 243090010299 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 243090010300 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243090010301 active site 243090010302 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090010303 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243090010304 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090010305 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243090010306 Outer membrane efflux protein; Region: OEP; pfam02321 243090010307 Outer membrane efflux protein; Region: OEP; pfam02321 243090010308 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243090010309 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243090010310 active site 243090010311 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090010312 Sulfatase; Region: Sulfatase; pfam00884 243090010313 Domain of unknown function (DUF303); Region: DUF303; pfam03629 243090010314 phosphate acetyltransferase; Reviewed; Region: PRK05632 243090010315 DRTGG domain; Region: DRTGG; pfam07085 243090010316 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 243090010317 Acetokinase family; Region: Acetate_kinase; cl17229 243090010318 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243090010319 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 243090010320 active site 243090010321 catalytic tetrad [active] 243090010322 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 243090010323 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 243090010324 putative active site [active] 243090010325 metal binding site [ion binding]; metal-binding site 243090010326 DoxX-like family; Region: DoxX_2; pfam13564 243090010327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090010328 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243090010329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090010330 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243090010331 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 243090010332 Vault protein inter-alpha-trypsin domain; Region: VIT; pfam08487 243090010333 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 243090010334 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243090010335 metal ion-dependent adhesion site (MIDAS); other site 243090010336 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 243090010337 Transposase IS200 like; Region: Y1_Tnp; cl00848 243090010338 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 243090010339 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090010340 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 243090010341 Eukaryotic metallothionein; Region: Metallothio_Euk; pfam12749 243090010342 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 243090010343 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 243090010344 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 243090010345 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 243090010346 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 243090010347 cosmid pircos-c4f11/ cosmid pircos-b1f11 joining point 243090010348 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 243090010349 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 243090010350 Protein of unknown function (DUF796); Region: DUF796; pfam05638 243090010351 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 243090010352 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 243090010353 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 243090010354 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 243090010355 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 243090010356 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 243090010357 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 243090010358 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 243090010359 PAAR motif; Region: PAAR_motif; pfam05488 243090010360 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090010361 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090010362 metal ion-dependent adhesion site (MIDAS); other site 243090010363 Cytochrome c; Region: Cytochrom_C; cl11414 243090010364 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 243090010365 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090010366 YHYH protein; Region: YHYH; pfam14240 243090010367 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 243090010368 substrate binding site [chemical binding]; other site 243090010369 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 243090010370 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090010371 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090010372 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 243090010373 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243090010374 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 243090010375 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090010376 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090010377 active site 243090010378 ATP binding site [chemical binding]; other site 243090010379 substrate binding site [chemical binding]; other site 243090010380 activation loop (A-loop); other site 243090010381 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 243090010382 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 243090010383 quinone interaction residues [chemical binding]; other site 243090010384 active site 243090010385 catalytic residues [active] 243090010386 FMN binding site [chemical binding]; other site 243090010387 substrate binding site [chemical binding]; other site 243090010388 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 243090010389 cosmid pircos-b1f11/ cosmid pircos-a2h03 joining point 243090010390 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090010391 Sulfatase; Region: Sulfatase; pfam00884 243090010392 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090010393 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 243090010394 Subtilase family; Region: Peptidase_S8; pfam00082 243090010395 active site 243090010396 catalytic triad [active] 243090010397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090010398 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243090010399 Walker A motif; other site 243090010400 ATP binding site [chemical binding]; other site 243090010401 Walker B motif; other site 243090010402 arginine finger; other site 243090010403 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 243090010404 Low molecular weight phosphatase family; Region: LMWPc; cl00105 243090010405 active site 243090010406 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 243090010407 active site 243090010408 catalytic site [active] 243090010409 substrate binding site [chemical binding]; other site 243090010410 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 243090010411 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 243090010412 nucleotide binding site/active site [active] 243090010413 HIT family signature motif; other site 243090010414 catalytic residue [active] 243090010415 DNA repair protein radc; Region: radc; TIGR00608 243090010416 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 243090010417 MPN+ (JAMM) motif; other site 243090010418 Zinc-binding site [ion binding]; other site 243090010419 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 243090010420 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 243090010421 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 243090010422 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 243090010423 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 243090010424 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 243090010425 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 243090010426 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 243090010427 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 243090010428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090010429 Walker A motif; other site 243090010430 ATP binding site [chemical binding]; other site 243090010431 Walker B motif; other site 243090010432 arginine finger; other site 243090010433 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 243090010434 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243090010435 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 243090010436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243090010437 active site 243090010438 motif I; other site 243090010439 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 243090010440 motif II; other site 243090010441 KpsF/GutQ family protein; Region: kpsF; TIGR00393 243090010442 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 243090010443 putative active site [active] 243090010444 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 243090010445 RDD family; Region: RDD; pfam06271 243090010446 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 243090010447 cosmid pircos-a2h03/ cosmid pircos-d1d09 joining point 243090010448 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 243090010449 This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803 243090010450 active site 243090010451 substrate binding site [chemical binding]; other site 243090010452 metal binding site [ion binding]; metal-binding site 243090010453 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 243090010454 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243090010455 active site 243090010456 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 243090010457 formylmethanofuran--tetrahydromethanopterin N-formyltransferase; Region: one_C_fhcD; TIGR03119 243090010458 FTR, proximal lobe; Region: FTR_C; pfam02741 243090010459 formylmethanofuran dehydrogenase subunit C; Region: one_C_dehyd_C; TIGR03122 243090010460 domain_subunit interface; other site 243090010461 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 243090010462 Competence protein; Region: Competence; pfam03772 243090010463 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243090010464 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 243090010465 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 243090010466 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 243090010467 tRNA; other site 243090010468 putative tRNA binding site [nucleotide binding]; other site 243090010469 putative NADP binding site [chemical binding]; other site 243090010470 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 243090010471 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090010472 Helix-turn-helix domain; Region: HTH_16; pfam12645 243090010473 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 243090010474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090010475 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090010476 DNA binding residues [nucleotide binding] 243090010477 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090010478 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090010479 active site 243090010480 ATP binding site [chemical binding]; other site 243090010481 substrate binding site [chemical binding]; other site 243090010482 activation loop (A-loop); other site 243090010483 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 243090010484 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 243090010485 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 243090010486 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 243090010487 substrate binding pocket [chemical binding]; other site 243090010488 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 243090010489 B12 binding site [chemical binding]; other site 243090010490 cobalt ligand [ion binding]; other site 243090010491 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 243090010492 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243090010493 active site 243090010494 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 243090010495 ketol-acid reductoisomerase; Provisional; Region: PRK05479 243090010496 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 243090010497 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 243090010498 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 243090010499 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 243090010500 putative valine binding site [chemical binding]; other site 243090010501 dimer interface [polypeptide binding]; other site 243090010502 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 243090010503 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 243090010504 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 243090010505 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 243090010506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090010507 FeS/SAM binding site; other site 243090010508 HemN C-terminal domain; Region: HemN_C; pfam06969 243090010509 PAS fold; Region: PAS_4; pfam08448 243090010510 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090010511 putative active site [active] 243090010512 heme pocket [chemical binding]; other site 243090010513 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243090010514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090010515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090010516 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090010517 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090010518 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090010519 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090010520 cosmid pircos-d1d09/ cosmid pircos-d3d11 joining point 243090010521 QPP; Region: QPP; pfam07640 243090010522 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090010523 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 243090010524 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243090010525 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 243090010526 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 243090010527 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 243090010528 flagellin; Provisional; Region: PRK12806 243090010529 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 243090010530 intracellular protease, PfpI family; Region: PfpI; TIGR01382 243090010531 conserved cys residue [active] 243090010532 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 243090010533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 243090010534 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 243090010535 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243090010536 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243090010537 DDE superfamily endonuclease; Region: DDE_5; pfam13546 243090010538 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 243090010539 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 243090010540 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 243090010541 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 243090010542 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 243090010543 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 243090010544 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 243090010545 dimer interface [polypeptide binding]; other site 243090010546 ssDNA binding site [nucleotide binding]; other site 243090010547 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243090010548 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 243090010549 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 243090010550 putative active site [active] 243090010551 catalytic residue [active] 243090010552 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 243090010553 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 243090010554 5S rRNA interface [nucleotide binding]; other site 243090010555 CTC domain interface [polypeptide binding]; other site 243090010556 L16 interface [polypeptide binding]; other site 243090010557 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 243090010558 pyruvate kinase; Region: PLN02623 243090010559 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 243090010560 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 243090010561 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 243090010562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090010563 Walker A motif; other site 243090010564 ATP binding site [chemical binding]; other site 243090010565 Walker B motif; other site 243090010566 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 243090010567 Protein melan-A; Region: MLANA; pfam14991 243090010568 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090010569 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090010570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243090010571 putative substrate translocation pore; other site 243090010572 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243090010573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090010574 S-adenosylmethionine binding site [chemical binding]; other site 243090010575 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 243090010576 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 243090010577 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 243090010578 Nucleoside recognition; Region: Gate; pfam07670 243090010579 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 243090010580 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 243090010581 DinB superfamily; Region: DinB_2; pfam12867 243090010582 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 243090010583 active site 243090010584 Calx-beta domain; Region: Calx-beta; cl02522 243090010585 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090010586 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090010587 cosmid pircos-d3d11/ cosmid pircos-d3h04 joining point 243090010588 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 243090010589 hypothetical protein; Validated; Region: PRK00029 243090010590 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 243090010591 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090010592 PA14 domain; Region: PA14; pfam07691 243090010593 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090010594 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090010595 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090010596 Planctomycetes uncharacterized domain TIGR03009; Region: plancto_dom_2 243090010597 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 243090010598 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090010599 FeS/SAM binding site; other site 243090010600 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090010601 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090010602 QPP; Region: QPP; pfam07640 243090010603 Pectic acid lyase; Region: Pec_lyase; pfam09492 243090010604 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 243090010605 Walker A/P-loop; other site 243090010606 ATP binding site [chemical binding]; other site 243090010607 Q-loop/lid; other site 243090010608 ABC transporter signature motif; other site 243090010609 Walker B; other site 243090010610 D-loop; other site 243090010611 H-loop/switch region; other site 243090010612 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090010613 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090010614 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 243090010615 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 243090010616 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 243090010617 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 243090010618 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 243090010619 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 243090010620 FeS assembly protein SufB; Region: sufB; TIGR01980 243090010621 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 243090010622 FeS assembly ATPase SufC; Region: sufC; TIGR01978 243090010623 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 243090010624 Walker A/P-loop; other site 243090010625 ATP binding site [chemical binding]; other site 243090010626 Q-loop/lid; other site 243090010627 ABC transporter signature motif; other site 243090010628 Walker B; other site 243090010629 D-loop; other site 243090010630 H-loop/switch region; other site 243090010631 Predicted transcriptional regulator [Transcription]; Region: COG2345 243090010632 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243090010633 putative DNA binding site [nucleotide binding]; other site 243090010634 putative Zn2+ binding site [ion binding]; other site 243090010635 Glucose dehydrogenase; Region: glucose_DH; cd08230 243090010636 NADP binding site [chemical binding]; other site 243090010637 catalytic Zn binding site [ion binding]; other site 243090010638 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243090010639 structural Zn binding site [ion binding]; other site 243090010640 dimer interface [polypeptide binding]; other site 243090010641 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 243090010642 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 243090010643 NAD binding site [chemical binding]; other site 243090010644 ligand binding site [chemical binding]; other site 243090010645 catalytic site [active] 243090010646 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 243090010647 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 243090010648 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 243090010649 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 243090010650 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243090010651 DNA-binding site [nucleotide binding]; DNA binding site 243090010652 RNA-binding motif; other site 243090010653 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090010654 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090010655 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090010656 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090010657 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090010658 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090010659 cosmid pircos-d3h04/ cosmid pircos-a4a04 joining point 243090010660 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090010661 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243090010662 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 243090010663 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243090010664 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl17448 243090010665 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 243090010666 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243090010667 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 243090010668 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243090010669 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 243090010670 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 243090010671 Uncharacterized conserved protein [Function unknown]; Region: COG2308 243090010672 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243090010673 active site 243090010674 metal binding site [ion binding]; metal-binding site 243090010675 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090010676 PQQ-like domain; Region: PQQ_2; pfam13360 243090010677 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090010678 active site 243090010679 Trp docking motif [polypeptide binding]; other site 243090010680 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 243090010681 Condensation domain; Region: Condensation; cl19241 243090010682 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243090010683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090010684 TPR motif; other site 243090010685 binding surface 243090010686 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090010687 Cytochrome c7; Region: Cytochrome_C7; pfam14522 243090010688 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090010689 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090010690 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090010691 cosmid pircos-a4a04/ cosmid pircos-c1f10 joining point 243090010692 Domain of unknown function (DUF303); Region: DUF303; pfam03629 243090010693 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 243090010694 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090010695 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090010696 DNA binding residues [nucleotide binding] 243090010697 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090010698 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090010699 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090010700 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090010701 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243090010702 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 243090010703 O-Antigen ligase; Region: Wzy_C; pfam04932 243090010704 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243090010705 dimerization interface [polypeptide binding]; other site 243090010706 putative DNA binding site [nucleotide binding]; other site 243090010707 putative Zn2+ binding site [ion binding]; other site 243090010708 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243090010709 Predicted dehydrogenase [General function prediction only]; Region: COG0579 243090010710 hydroxyglutarate oxidase; Provisional; Region: PRK11728 243090010711 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 243090010712 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243090010713 Zn2+ binding site [ion binding]; other site 243090010714 Mg2+ binding site [ion binding]; other site 243090010715 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 243090010716 PEGA domain; Region: PEGA; pfam08308 243090010717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090010718 S-adenosylmethionine binding site [chemical binding]; other site 243090010719 Protein of unknown function (DUF1387); Region: DUF1387; pfam07139 243090010720 Peptidase S46; Region: Peptidase_S46; pfam10459 243090010721 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 243090010722 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243090010723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243090010724 Walker A/P-loop; other site 243090010725 ATP binding site [chemical binding]; other site 243090010726 Q-loop/lid; other site 243090010727 ABC transporter signature motif; other site 243090010728 Walker B; other site 243090010729 D-loop; other site 243090010730 H-loop/switch region; other site 243090010731 putative heme peroxidase; Provisional; Region: PRK12276 243090010732 fructoselysine 3-epimerase; Provisional; Region: PRK09856 243090010733 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090010734 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 243090010735 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 243090010736 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243090010737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243090010738 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243090010739 Protein of unknown function (DUF1590); Region: DUF1590; pfam07629 243090010740 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090010741 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090010742 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090010743 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 243090010744 Kelch domain; Region: Kelch; smart00612 243090010745 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 243090010746 Kelch motif; Region: Kelch_1; pfam01344 243090010747 Protein of unknown function (DUF1582); Region: DUF1582; pfam07621 243090010748 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 243090010749 DNA polymerase III subunit beta; Validated; Region: PRK05643 243090010750 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 243090010751 putative DNA binding surface [nucleotide binding]; other site 243090010752 dimer interface [polypeptide binding]; other site 243090010753 beta-clamp/clamp loader binding surface; other site 243090010754 beta-clamp/translesion DNA polymerase binding surface; other site 243090010755 Protein of unknown function (DUF721); Region: DUF721; pfam05258 243090010756 cosmid pircos-c1f10/ cosmid pircos-a4c11 joining point 243090010757 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 243090010758 substrate binding site [chemical binding]; other site 243090010759 glutamase interaction surface [polypeptide binding]; other site 243090010760 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 243090010761 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 243090010762 purine monophosphate binding site [chemical binding]; other site 243090010763 dimer interface [polypeptide binding]; other site 243090010764 putative catalytic residues [active] 243090010765 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 243090010766 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 243090010767 active site 243090010768 ribulose/triose binding site [chemical binding]; other site 243090010769 phosphate binding site [ion binding]; other site 243090010770 substrate (anthranilate) binding pocket [chemical binding]; other site 243090010771 product (indole) binding pocket [chemical binding]; other site 243090010772 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090010773 Sulfatase; Region: Sulfatase; pfam00884 243090010774 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090010775 Sulfatase; Region: Sulfatase; cl19157 243090010776 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090010777 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090010778 active site 243090010779 ATP binding site [chemical binding]; other site 243090010780 substrate binding site [chemical binding]; other site 243090010781 activation loop (A-loop); other site 243090010782 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 243090010783 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 243090010784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090010785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090010786 DNA binding residues [nucleotide binding] 243090010787 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090010788 active site 243090010789 PQQ-like domain; Region: PQQ_2; pfam13360 243090010790 Trp docking motif [polypeptide binding]; other site 243090010791 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 243090010792 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090010793 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 243090010794 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 243090010795 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243090010796 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090010797 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090010798 active site 243090010799 ATP binding site [chemical binding]; other site 243090010800 substrate binding site [chemical binding]; other site 243090010801 activation loop (A-loop); other site 243090010802 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 243090010803 Protein of unknown function (DUF1590); Region: DUF1590; pfam07629 243090010804 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090010805 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 243090010806 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 243090010807 Sulfate transporter family; Region: Sulfate_transp; cl19250 243090010808 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 243090010809 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243090010810 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090010811 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 243090010812 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090010813 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090010814 Ca2+ binding site [ion binding]; other site 243090010815 CARDB; Region: CARDB; pfam07705 243090010816 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090010817 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090010818 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090010819 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090010820 active site 243090010821 ATP binding site [chemical binding]; other site 243090010822 substrate binding site [chemical binding]; other site 243090010823 activation loop (A-loop); other site 243090010824 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090010825 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090010826 structural tetrad; other site 243090010827 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090010828 structural tetrad; other site 243090010829 ECF sigma factor; Region: Sigma70_ECF; pfam07638 243090010830 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243090010831 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243090010832 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090010833 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243090010834 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 243090010835 putative ligand binding site [chemical binding]; other site 243090010836 cosmid pircos-a4c11/ cosmid pircos-b1g08 joining point 243090010837 cysteine synthase; Region: PLN02565 243090010838 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 243090010839 dimer interface [polypeptide binding]; other site 243090010840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090010841 catalytic residue [active] 243090010842 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 243090010843 NAD(P) binding site [chemical binding]; other site 243090010844 catalytic residues [active] 243090010845 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 243090010846 Immediate early response protein (IER); Region: IER; pfam05760 243090010847 Protein of unknown function DUF111; Region: DUF111; pfam01969 243090010848 oligoendopeptidase F; Region: pepF; TIGR00181 243090010849 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 243090010850 active site 243090010851 Zn binding site [ion binding]; other site 243090010852 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 243090010853 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 243090010854 Walker A/P-loop; other site 243090010855 ATP binding site [chemical binding]; other site 243090010856 Q-loop/lid; other site 243090010857 ABC transporter signature motif; other site 243090010858 Walker B; other site 243090010859 D-loop; other site 243090010860 H-loop/switch region; other site 243090010861 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 243090010862 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 243090010863 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 243090010864 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243090010865 active site 243090010866 dihydroorotase; Provisional; Region: PRK07575 243090010867 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243090010868 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 243090010869 active site 243090010870 transketolase; Reviewed; Region: PRK05899 243090010871 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 243090010872 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 243090010873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 243090010874 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 243090010875 ATP synthase A chain; Region: ATP-synt_A; cl00413 243090010876 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]; Region: AtpE; COG0636 243090010877 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 243090010878 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 243090010879 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 243090010880 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 243090010881 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243090010882 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 243090010883 beta subunit interaction interface [polypeptide binding]; other site 243090010884 Walker A motif; other site 243090010885 ATP binding site [chemical binding]; other site 243090010886 Walker B motif; other site 243090010887 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243090010888 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 243090010889 core domain interface [polypeptide binding]; other site 243090010890 delta subunit interface [polypeptide binding]; other site 243090010891 epsilon subunit interface [polypeptide binding]; other site 243090010892 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 243090010893 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243090010894 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 243090010895 alpha subunit interaction interface [polypeptide binding]; other site 243090010896 Walker A motif; other site 243090010897 ATP binding site [chemical binding]; other site 243090010898 Walker B motif; other site 243090010899 inhibitor binding site; inhibition site 243090010900 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243090010901 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 243090010902 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 243090010903 gamma subunit interface [polypeptide binding]; other site 243090010904 epsilon subunit interface [polypeptide binding]; other site 243090010905 LBP interface [polypeptide binding]; other site 243090010906 TIR domain; Region: TIR_2; pfam13676 243090010907 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090010908 Walker A motif; other site 243090010909 ATP binding site [chemical binding]; other site 243090010910 Walker B motif; other site 243090010911 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090010912 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 243090010913 Walker A motif; other site 243090010914 ATP binding site [chemical binding]; other site 243090010915 Walker B motif; other site 243090010916 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 243090010917 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 243090010918 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 243090010919 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 243090010920 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090010921 Sulfatase; Region: Sulfatase; pfam00884 243090010922 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 243090010923 catalytic triad [active] 243090010924 conserved cis-peptide bond; other site 243090010925 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 243090010926 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090010927 cosmid pircos-b1g08/ cosmid pircos-a3g10 joining point 243090010928 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090010929 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 243090010930 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243090010931 HSP70 interaction site [polypeptide binding]; other site 243090010932 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 243090010933 substrate binding site [polypeptide binding]; other site 243090010934 dimer interface [polypeptide binding]; other site 243090010935 haloalkane dehalogenase; Provisional; Region: PRK03592 243090010936 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243090010937 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 243090010938 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090010939 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090010940 protein binding site [polypeptide binding]; other site 243090010941 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 243090010942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090010943 Coenzyme A binding pocket [chemical binding]; other site 243090010944 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 243090010945 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243090010946 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 243090010947 Global regulator protein family; Region: CsrA; pfam02599 243090010948 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 243090010949 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090010950 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090010951 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 243090010952 putative active site [active] 243090010953 catalytic site [active] 243090010954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090010955 phytoene desaturase; Region: crtI_fam; TIGR02734 243090010956 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 243090010957 RNA/DNA hybrid binding site [nucleotide binding]; other site 243090010958 active site 243090010959 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 243090010960 classical (c) SDRs; Region: SDR_c; cd05233 243090010961 NAD(P) binding site [chemical binding]; other site 243090010962 active site 243090010963 biotin synthase; Validated; Region: PRK06256 243090010964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090010965 FeS/SAM binding site; other site 243090010966 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 243090010967 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 243090010968 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 243090010969 domain interfaces; other site 243090010970 active site 243090010971 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243090010972 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243090010973 putative dimer interface [polypeptide binding]; other site 243090010974 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243090010975 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243090010976 putative dimer interface [polypeptide binding]; other site 243090010977 cosmid pircos-a3g10/ cosmid pircos-a2e10 joining point 243090010978 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 243090010979 inhibitor site; inhibition site 243090010980 active site 243090010981 dimer interface [polypeptide binding]; other site 243090010982 catalytic residue [active] 243090010983 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 243090010984 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 243090010985 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 243090010986 NADP binding site [chemical binding]; other site 243090010987 formaldehyde-activating enzyme; Region: one_C_fae; TIGR03126 243090010988 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243090010989 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 243090010990 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 243090010991 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 243090010992 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 243090010993 tetramer interface [polypeptide binding]; other site 243090010994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090010995 catalytic residue [active] 243090010996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090010997 active site 243090010998 phosphorylation site [posttranslational modification] 243090010999 intermolecular recognition site; other site 243090011000 dimerization interface [polypeptide binding]; other site 243090011001 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243090011002 metal binding site [ion binding]; metal-binding site 243090011003 active site 243090011004 I-site; other site 243090011005 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 243090011006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243090011007 putative substrate translocation pore; other site 243090011008 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 243090011009 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243090011010 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243090011011 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 243090011012 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090011013 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243090011014 putative active site [active] 243090011015 heme pocket [chemical binding]; other site 243090011016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090011017 dimer interface [polypeptide binding]; other site 243090011018 phosphorylation site [posttranslational modification] 243090011019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090011020 ATP binding site [chemical binding]; other site 243090011021 Mg2+ binding site [ion binding]; other site 243090011022 G-X-G motif; other site 243090011023 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243090011024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090011025 active site 243090011026 phosphorylation site [posttranslational modification] 243090011027 intermolecular recognition site; other site 243090011028 dimerization interface [polypeptide binding]; other site 243090011029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090011030 Walker A motif; other site 243090011031 ATP binding site [chemical binding]; other site 243090011032 Walker B motif; other site 243090011033 arginine finger; other site 243090011034 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243090011035 cosmid pircos-a2e10/ cosmid pircos-a3f08 joining point 243090011036 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 243090011037 high affinity sulphate transporter 1; Region: sulP; TIGR00815 243090011038 Sulfate transporter family; Region: Sulfate_transp; cl19250 243090011039 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 243090011040 putative rRNA binding site [nucleotide binding]; other site 243090011041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243090011042 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090011043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090011044 active site 243090011045 phosphorylation site [posttranslational modification] 243090011046 intermolecular recognition site; other site 243090011047 dimerization interface [polypeptide binding]; other site 243090011048 Protein kinase domain; Region: Pkinase; pfam00069 243090011049 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090011050 active site 243090011051 ATP binding site [chemical binding]; other site 243090011052 substrate binding site [chemical binding]; other site 243090011053 activation loop (A-loop); other site 243090011054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090011055 dimer interface [polypeptide binding]; other site 243090011056 phosphorylation site [posttranslational modification] 243090011057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090011058 ATP binding site [chemical binding]; other site 243090011059 Mg2+ binding site [ion binding]; other site 243090011060 G-X-G motif; other site 243090011061 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243090011062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090011063 active site 243090011064 phosphorylation site [posttranslational modification] 243090011065 intermolecular recognition site; other site 243090011066 dimerization interface [polypeptide binding]; other site 243090011067 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 243090011068 putative binding surface; other site 243090011069 active site 243090011070 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090011071 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090011072 active site 243090011073 ATP binding site [chemical binding]; other site 243090011074 substrate binding site [chemical binding]; other site 243090011075 activation loop (A-loop); other site 243090011076 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 243090011077 active site 243090011078 dimer interface [polypeptide binding]; other site 243090011079 TPR repeat; Region: TPR_11; pfam13414 243090011080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090011081 binding surface 243090011082 TPR motif; other site 243090011083 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090011084 Tetratricopeptide repeat; Region: TPR_17; pfam13431 243090011085 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090011086 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 243090011087 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 243090011088 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090011089 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243090011090 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090011091 DNA binding residues [nucleotide binding] 243090011092 Methyltransferase domain; Region: Methyltransf_25; pfam13649 243090011093 DinB superfamily; Region: DinB_2; pfam12867 243090011094 Protein of unknown function, DUF393; Region: DUF393; pfam04134 243090011095 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090011096 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 243090011097 Parvovirus non-structural protein NS1; Region: Parvo_NS1; pfam01057 243090011098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090011099 Walker A motif; other site 243090011100 ATP binding site [chemical binding]; other site 243090011101 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090011102 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090011103 active site 243090011104 ATP binding site [chemical binding]; other site 243090011105 substrate binding site [chemical binding]; other site 243090011106 activation loop (A-loop); other site 243090011107 Tubulin like; Region: Tubulin_2; pfam13809 243090011108 cosmid pircos-a3f08/ cosmid pircos-c4d10 joining point 243090011109 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 243090011110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243090011111 motif II; other site 243090011112 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 243090011113 MMPL family; Region: MMPL; cl14618 243090011114 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 243090011115 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243090011116 catalytic residues [active] 243090011117 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 243090011118 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 243090011119 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090011120 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090011121 active site 243090011122 ATP binding site [chemical binding]; other site 243090011123 substrate binding site [chemical binding]; other site 243090011124 activation loop (A-loop); other site 243090011125 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 243090011126 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 243090011127 ligand binding site [chemical binding]; other site 243090011128 active site 243090011129 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 243090011130 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 243090011131 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243090011132 acyl-activating enzyme (AAE) consensus motif; other site 243090011133 AMP binding site [chemical binding]; other site 243090011134 active site 243090011135 CoA binding site [chemical binding]; other site 243090011136 Chain length determinant protein; Region: Wzz; pfam02706 243090011137 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 243090011138 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 243090011139 AAA domain; Region: AAA_31; pfam13614 243090011140 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243090011141 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 243090011142 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 243090011143 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 243090011144 putative active site [active] 243090011145 putative catalytic triad [active] 243090011146 EF-hand domain pair; Region: EF-hand_7; pfam13499 243090011147 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090011148 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090011149 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 243090011150 PA14 domain; Region: PA14; pfam07691 243090011151 Calx-beta domain; Region: Calx-beta; cl02522 243090011152 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 243090011153 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090011154 TIGR03032 family protein; Region: TIGR03032 243090011155 PQQ-like domain; Region: PQQ_2; pfam13360 243090011156 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 243090011157 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090011158 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090011159 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090011160 cosmid pircos-c4d10/ cosmid pircos-b2c05 joining point 243090011161 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243090011162 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 243090011163 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 243090011164 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 243090011165 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 243090011166 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090011167 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 243090011168 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090011169 putative ADP-binding pocket [chemical binding]; other site 243090011170 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 243090011171 CoA binding domain; Region: CoA_binding; cl17356 243090011172 Bacterial sugar transferase; Region: Bac_transf; pfam02397 243090011173 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 243090011174 B12 binding site [chemical binding]; other site 243090011175 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243090011176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090011177 FeS/SAM binding site; other site 243090011178 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 243090011179 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 243090011180 Male sterility protein; Region: NAD_binding_4; pfam07993 243090011181 putative NAD(P) binding site [chemical binding]; other site 243090011182 active site 243090011183 putative substrate binding site [chemical binding]; other site 243090011184 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243090011185 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 243090011186 active site 243090011187 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 243090011188 active site 243090011189 Acyl transferase domain; Region: Acyl_transf_1; cl08282 243090011190 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 243090011191 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 243090011192 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 243090011193 putative NADP binding site [chemical binding]; other site 243090011194 active site 243090011195 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 243090011196 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243090011197 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243090011198 [2Fe-2S] cluster binding site [ion binding]; other site 243090011199 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 243090011200 alpha subunit interface [polypeptide binding]; other site 243090011201 active site 243090011202 substrate binding site [chemical binding]; other site 243090011203 Fe binding site [ion binding]; other site 243090011204 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 243090011205 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 243090011206 putative NAD(P) binding site [chemical binding]; other site 243090011207 active site 243090011208 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 243090011209 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 243090011210 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 243090011211 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243090011212 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090011213 ferredoxin-NADP reductase; Provisional; Region: PRK10926 243090011214 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 243090011215 FAD binding pocket [chemical binding]; other site 243090011216 FAD binding motif [chemical binding]; other site 243090011217 phosphate binding motif [ion binding]; other site 243090011218 beta-alpha-beta structure motif; other site 243090011219 NAD binding pocket [chemical binding]; other site 243090011220 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 243090011221 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 243090011222 ligand binding site; other site 243090011223 oligomer interface; other site 243090011224 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 243090011225 dimer interface [polypeptide binding]; other site 243090011226 N-terminal domain interface [polypeptide binding]; other site 243090011227 sulfate 1 binding site; other site 243090011228 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 243090011229 cosmid pircos-b2c05/ cosmid pircos-a1f09 joining point 243090011230 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 243090011231 rRNA binding site [nucleotide binding]; other site 243090011232 predicted 30S ribosome binding site; other site 243090011233 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 243090011234 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 243090011235 23S rRNA interface [nucleotide binding]; other site 243090011236 L3 interface [polypeptide binding]; other site 243090011237 GAF domain; Region: GAF_3; pfam13492 243090011238 GAF domain; Region: GAF; pfam01590 243090011239 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 243090011240 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090011241 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090011242 HlyD family secretion protein; Region: HlyD; pfam00529 243090011243 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090011244 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 243090011245 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 243090011246 Peptidase family M50; Region: Peptidase_M50; pfam02163 243090011247 active site 243090011248 putative substrate binding region [chemical binding]; other site 243090011249 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 243090011250 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090011251 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 243090011252 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 243090011253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090011254 ATP binding site [chemical binding]; other site 243090011255 putative Mg++ binding site [ion binding]; other site 243090011256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090011257 nucleotide binding region [chemical binding]; other site 243090011258 ATP-binding site [chemical binding]; other site 243090011259 RQC domain; Region: RQC; pfam09382 243090011260 HRDC domain; Region: HRDC; pfam00570 243090011261 Helix-turn-helix domain; Region: HTH_40; pfam14493 243090011262 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090011263 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243090011264 putative active site [active] 243090011265 heme pocket [chemical binding]; other site 243090011266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090011267 putative active site [active] 243090011268 heme pocket [chemical binding]; other site 243090011269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090011270 dimer interface [polypeptide binding]; other site 243090011271 phosphorylation site [posttranslational modification] 243090011272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090011273 ATP binding site [chemical binding]; other site 243090011274 Mg2+ binding site [ion binding]; other site 243090011275 G-X-G motif; other site 243090011276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090011277 active site 243090011278 phosphorylation site [posttranslational modification] 243090011279 intermolecular recognition site; other site 243090011280 dimerization interface [polypeptide binding]; other site 243090011281 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 243090011282 putative binding surface; other site 243090011283 active site 243090011284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090011285 active site 243090011286 phosphorylation site [posttranslational modification] 243090011287 intermolecular recognition site; other site 243090011288 dimerization interface [polypeptide binding]; other site 243090011289 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 243090011290 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 243090011291 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 243090011292 substrate binding site [chemical binding]; other site 243090011293 hinge regions; other site 243090011294 ADP binding site [chemical binding]; other site 243090011295 catalytic site [active] 243090011296 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090011297 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090011298 Glycosyl-hydrolase 97 N-terminal; Region: GH97_N; pfam14508 243090011299 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 243090011300 Glycosyl-hydrolase 97 C-terminal, oligomerization; Region: GH97_C; pfam14509 243090011301 Competence-damaged protein; Region: CinA; cl00666 243090011302 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 243090011303 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 243090011304 CMP-binding site; other site 243090011305 The sites determining sugar specificity; other site 243090011306 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 243090011307 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243090011308 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243090011309 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 243090011310 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243090011311 Protein of unknown function DUF58; Region: DUF58; pfam01882 243090011312 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090011313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090011314 Walker A motif; other site 243090011315 ATP binding site [chemical binding]; other site 243090011316 Walker B motif; other site 243090011317 arginine finger; other site 243090011318 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 243090011319 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 243090011320 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 243090011321 cosmid pircos-a1f09/ cosmid pircos-d3h03 joining point 243090011322 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 243090011323 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 243090011324 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 243090011325 RNA binding site [nucleotide binding]; other site 243090011326 Protein of unknown function (DUF1586); Region: DUF1586; pfam07625 243090011327 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 243090011328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090011329 S-adenosylmethionine binding site [chemical binding]; other site 243090011330 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl19835 243090011331 SpoVG; Region: SpoVG; pfam04026 243090011332 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 243090011333 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 243090011334 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 243090011335 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 243090011336 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 243090011337 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 243090011338 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 243090011339 trimer interface [polypeptide binding]; other site 243090011340 active site 243090011341 UDP-GlcNAc binding site [chemical binding]; other site 243090011342 lipid binding site [chemical binding]; lipid-binding site 243090011343 TPR repeat; Region: TPR_11; pfam13414 243090011344 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090011345 TPR motif; other site 243090011346 binding surface 243090011347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090011348 binding surface 243090011349 TPR motif; other site 243090011350 Tetratricopeptide repeat; Region: TPR_19; pfam14559 243090011351 glycyl-tRNA synthetase; Provisional; Region: PRK04173 243090011352 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 243090011353 dimer interface [polypeptide binding]; other site 243090011354 motif 1; other site 243090011355 active site 243090011356 motif 2; other site 243090011357 motif 3; other site 243090011358 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 243090011359 anticodon binding site; other site 243090011360 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 243090011361 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 243090011362 putative active site [active] 243090011363 putative metal binding site [ion binding]; other site 243090011364 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 243090011365 putative Iron-sulfur protein interface [polypeptide binding]; other site 243090011366 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 243090011367 proximal heme binding site [chemical binding]; other site 243090011368 distal heme binding site [chemical binding]; other site 243090011369 putative dimer interface [polypeptide binding]; other site 243090011370 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 243090011371 L-aspartate oxidase; Provisional; Region: PRK06175 243090011372 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 243090011373 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 243090011374 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 243090011375 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243090011376 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 243090011377 EF-hand domain pair; Region: EF-hand_7; pfam13499 243090011378 Ca2+ binding site [ion binding]; other site 243090011379 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 243090011380 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090011381 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090011382 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090011383 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090011384 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 243090011385 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 243090011386 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 243090011387 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 243090011388 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 243090011389 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090011390 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090011391 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090011392 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 243090011393 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090011394 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090011395 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090011396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090011397 binding surface 243090011398 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243090011399 TPR motif; other site 243090011400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090011401 binding surface 243090011402 TPR motif; other site 243090011403 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090011404 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090011405 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090011406 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090011407 FadR C-terminal domain; Region: FadR_C; pfam07840 243090011408 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 243090011409 cosmid pircos-d3h03/ cosmid gap joining point 243090011410 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 243090011411 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 243090011412 active site 243090011413 cosmid gap/ cosmid pircos-a1g07 joining point 243090011414 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 243090011415 putative active site [active] 243090011416 putative metal binding site [ion binding]; other site 243090011417 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 243090011418 Acyltransferase family; Region: Acyl_transf_3; pfam01757 243090011419 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243090011420 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243090011421 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 243090011422 active site 243090011423 ADP/pyrophosphate binding site [chemical binding]; other site 243090011424 allosteric effector site; other site 243090011425 fructose-1,6-bisphosphate binding site; other site 243090011426 pyruvate carboxylase; Reviewed; Region: PRK12999 243090011427 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243090011428 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243090011429 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 243090011430 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 243090011431 active site 243090011432 catalytic residues [active] 243090011433 metal binding site [ion binding]; metal-binding site 243090011434 homodimer binding site [polypeptide binding]; other site 243090011435 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 243090011436 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243090011437 carboxyltransferase (CT) interaction site; other site 243090011438 biotinylation site [posttranslational modification]; other site 243090011439 Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168 243090011440 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090011441 Sulfatase; Region: Sulfatase; pfam00884 243090011442 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090011443 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090011444 Sulfatase; Region: Sulfatase; pfam00884 243090011445 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090011446 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 243090011447 putative ADP-binding pocket [chemical binding]; other site 243090011448 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 243090011449 galactarate dehydratase; Region: galactar-dH20; TIGR03248 243090011450 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 243090011451 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 243090011452 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 243090011453 CoA-ligase; Region: Ligase_CoA; pfam00549 243090011454 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 243090011455 CoA binding domain; Region: CoA_binding; smart00881 243090011456 CoA-ligase; Region: Ligase_CoA; pfam00549 243090011457 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 243090011458 oligomerisation interface [polypeptide binding]; other site 243090011459 mobile loop; other site 243090011460 roof hairpin; other site 243090011461 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 243090011462 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 243090011463 ring oligomerisation interface [polypeptide binding]; other site 243090011464 ATP/Mg binding site [chemical binding]; other site 243090011465 stacking interactions; other site 243090011466 hinge regions; other site 243090011467 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243090011468 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243090011469 [2Fe-2S] cluster binding site [ion binding]; other site 243090011470 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 243090011471 alpha subunit interface [polypeptide binding]; other site 243090011472 active site 243090011473 substrate binding site [chemical binding]; other site 243090011474 Fe binding site [ion binding]; other site 243090011475 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 243090011476 rRNA interaction site [nucleotide binding]; other site 243090011477 S8 interaction site; other site 243090011478 putative laminin-1 binding site; other site 243090011479 elongation factor Ts; Provisional; Region: tsf; PRK09377 243090011480 UBA/TS-N domain; Region: UBA; pfam00627 243090011481 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090011482 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090011483 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090011484 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090011485 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 243090011486 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 243090011487 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 243090011488 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 243090011489 cosmid pircos-a1g07/ cosmid pircos-a3c07 joining point 243090011490 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 243090011491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090011492 catalytic residue [active] 243090011493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090011494 S-adenosylmethionine binding site [chemical binding]; other site 243090011495 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 243090011496 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243090011497 catalytic residue [active] 243090011498 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 243090011499 active site 243090011500 (T/H)XGH motif; other site 243090011501 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 243090011502 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243090011503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090011504 AAA domain; Region: AAA_23; pfam13476 243090011505 AAA domain; Region: AAA_27; pfam13514 243090011506 Walker A/P-loop; other site 243090011507 ATP binding site [chemical binding]; other site 243090011508 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 243090011509 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 243090011510 active site 243090011511 metal binding site [ion binding]; metal-binding site 243090011512 DNA binding site [nucleotide binding] 243090011513 Domain of unknown function DUF11; Region: DUF11; pfam01345 243090011514 Domain of unknown function DUF11; Region: DUF11; pfam01345 243090011515 Domain of unknown function DUF11; Region: DUF11; pfam01345 243090011516 Domain of unknown function DUF11; Region: DUF11; pfam01345 243090011517 Domain of unknown function DUF11; Region: DUF11; pfam01345 243090011518 conserved repeat domain; Region: B_ant_repeat; TIGR01451 243090011519 conserved repeat domain; Region: B_ant_repeat; TIGR01451 243090011520 Domain of unknown function DUF11; Region: DUF11; pfam01345 243090011521 Domain of unknown function DUF11; Region: DUF11; pfam01345 243090011522 conserved repeat domain; Region: B_ant_repeat; TIGR01451 243090011523 conserved repeat domain; Region: B_ant_repeat; TIGR01451 243090011524 Sulfatase; Region: Sulfatase; cl19157 243090011525 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243090011526 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 243090011527 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090011528 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090011529 HEAT repeats; Region: HEAT_2; pfam13646 243090011530 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090011531 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090011532 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 243090011533 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 243090011534 FMN binding site [chemical binding]; other site 243090011535 active site 243090011536 catalytic residues [active] 243090011537 substrate binding site [chemical binding]; other site 243090011538 23S rRNA-intervening sequence protein; Region: 23S_rRNA_IVP; cl05287 243090011539 NIMA-related protein kinase; Provisional; Region: PTZ00266 243090011540 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 243090011541 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 243090011542 DNA circularisation protein N-terminus; Region: DNA_circ_N; cl19561 243090011543 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243090011544 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243090011545 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 243090011546 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243090011547 cosmid pircos-a3c07/ cosmid pircos-b2g02 joining point 243090011548 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090011549 PQQ-like domain; Region: PQQ_2; pfam13360 243090011550 Trp docking motif [polypeptide binding]; other site 243090011551 active site 243090011552 PQQ-like domain; Region: PQQ_2; pfam13360 243090011553 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 243090011554 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 243090011555 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 243090011556 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 243090011557 nucleotide binding pocket [chemical binding]; other site 243090011558 K-X-D-G motif; other site 243090011559 catalytic site [active] 243090011560 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 243090011561 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 243090011562 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 243090011563 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 243090011564 Dimer interface [polypeptide binding]; other site 243090011565 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090011566 Trp docking motif [polypeptide binding]; other site 243090011567 PQQ-like domain; Region: PQQ_2; pfam13360 243090011568 active site 243090011569 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 243090011570 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243090011571 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 243090011572 dimanganese center [ion binding]; other site 243090011573 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 243090011574 Protein of unknown function (DUF1584); Region: PEGSRP; pfam07623 243090011575 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 243090011576 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243090011577 NAD binding site [chemical binding]; other site 243090011578 catalytic Zn binding site [ion binding]; other site 243090011579 structural Zn binding site [ion binding]; other site 243090011580 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 243090011581 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 243090011582 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 243090011583 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243090011584 cosmid pircos-b2g02/ cosmid pircos-a4h12 joining point 243090011585 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243090011586 Methyltransferase domain; Region: Methyltransf_26; pfam13659 243090011587 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 243090011588 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 243090011589 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090011590 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 243090011591 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090011592 ATP binding site [chemical binding]; other site 243090011593 putative Mg++ binding site [ion binding]; other site 243090011594 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090011595 nucleotide binding region [chemical binding]; other site 243090011596 ATP-binding site [chemical binding]; other site 243090011597 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 243090011598 Protein of unknown function (DUF1580); Region: DUF1580; pfam07618 243090011599 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 243090011600 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 243090011601 active site 243090011602 catalytic residues [active] 243090011603 DNA binding site [nucleotide binding] 243090011604 Int/Topo IB signature motif; other site 243090011605 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 243090011606 MOFRL family; Region: MOFRL; pfam05161 243090011607 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 243090011608 putative catalytic residue [active] 243090011609 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 243090011610 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 243090011611 NAD binding site [chemical binding]; other site 243090011612 homotetramer interface [polypeptide binding]; other site 243090011613 homodimer interface [polypeptide binding]; other site 243090011614 substrate binding site [chemical binding]; other site 243090011615 active site 243090011616 GAF domain; Region: GAF_3; pfam13492 243090011617 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 243090011618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090011619 Walker A motif; other site 243090011620 ATP binding site [chemical binding]; other site 243090011621 Walker B motif; other site 243090011622 arginine finger; other site 243090011623 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243090011624 Predicted esterase [General function prediction only]; Region: COG0400 243090011625 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090011626 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 243090011627 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090011628 metal ion-dependent adhesion site (MIDAS); other site 243090011629 Protein of unknown function (DUF1355); Region: DUF1355; pfam07090 243090011630 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 243090011631 active site 243090011632 metal binding site [ion binding]; metal-binding site 243090011633 Protein of unknown function (DUF1598); Region: DUF1598; pfam07643 243090011634 AAA ATPase domain; Region: AAA_16; pfam13191 243090011635 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 243090011636 DNA polymerase III subunit delta'; Validated; Region: PRK08485 243090011637 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 243090011638 cosmid pircos-a4h12/ cosmid pircos-c4c05 joining point 243090011639 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 243090011640 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 243090011641 Low molecular weight phosphatase family; Region: LMWPc; cd00115 243090011642 active site 243090011643 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090011644 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243090011645 NHL repeat; Region: NHL; pfam01436 243090011646 NHL repeat; Region: NHL; pfam01436 243090011647 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502 243090011648 active site 243090011649 catalytic triad [active] 243090011650 oxyanion hole [active] 243090011651 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 243090011652 oligomer interface [polypeptide binding]; other site 243090011653 active site residues [active] 243090011654 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 243090011655 oligomer interface [polypeptide binding]; other site 243090011656 active site residues [active] 243090011657 argininosuccinate lyase; Provisional; Region: PRK00855 243090011658 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 243090011659 active sites [active] 243090011660 tetramer interface [polypeptide binding]; other site 243090011661 PQQ-like domain; Region: PQQ_2; pfam13360 243090011662 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090011663 Trp docking motif [polypeptide binding]; other site 243090011664 active site 243090011665 PQQ-like domain; Region: PQQ_2; pfam13360 243090011666 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 243090011667 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 243090011668 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 243090011669 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243090011670 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 243090011671 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 243090011672 GatB domain; Region: GatB_Yqey; pfam02637 243090011673 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 243090011674 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243090011675 Probable pheophorbidase; Region: PLN02965; cl17657 243090011676 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 243090011677 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 243090011678 active site 243090011679 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090011680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243090011681 NAD(P) binding site [chemical binding]; other site 243090011682 active site 243090011683 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 243090011684 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 243090011685 cosmid pircos-c4c05/ cosmid pircos-b1g07 joining point 243090011686 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 243090011687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243090011688 Walker A/P-loop; other site 243090011689 ATP binding site [chemical binding]; other site 243090011690 Q-loop/lid; other site 243090011691 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243090011692 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 243090011693 CAAX protease self-immunity; Region: Abi; pfam02517 243090011694 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 243090011695 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 243090011696 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 243090011697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090011698 FeS/SAM binding site; other site 243090011699 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 243090011700 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 243090011701 dimer interface [polypeptide binding]; other site 243090011702 putative anticodon binding site; other site 243090011703 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 243090011704 motif 1; other site 243090011705 active site 243090011706 motif 2; other site 243090011707 motif 3; other site 243090011708 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 243090011709 ammonium transporter; Region: amt; TIGR00836 243090011710 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243090011711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090011712 dimer interface [polypeptide binding]; other site 243090011713 phosphorylation site [posttranslational modification] 243090011714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090011715 ATP binding site [chemical binding]; other site 243090011716 Mg2+ binding site [ion binding]; other site 243090011717 G-X-G motif; other site 243090011718 threonine synthase; Validated; Region: PRK06260 243090011719 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 243090011720 homodimer interface [polypeptide binding]; other site 243090011721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090011722 catalytic residue [active] 243090011723 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 243090011724 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 243090011725 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 243090011726 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 243090011727 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 243090011728 active site 243090011729 metal binding site [ion binding]; metal-binding site 243090011730 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]; Region: ApaH; COG0639 243090011731 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 243090011732 active site 243090011733 metal binding site [ion binding]; metal-binding site 243090011734 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 243090011735 Glycoprotease family; Region: Peptidase_M22; pfam00814 243090011736 Surface antigen; Region: Bac_surface_Ag; pfam01103 243090011737 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243090011738 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243090011739 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243090011740 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243090011741 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 243090011742 hypothetical protein; Provisional; Region: PRK02399 243090011743 CheB methylesterase; Region: CheB_methylest; pfam01339 243090011744 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 243090011745 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 243090011746 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 243090011747 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243090011748 PAS domain; Region: PAS_10; pfam13596 243090011749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090011750 putative active site [active] 243090011751 PAS fold; Region: PAS_3; pfam08447 243090011752 heme pocket [chemical binding]; other site 243090011753 PAS fold; Region: PAS_4; pfam08448 243090011754 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090011755 putative active site [active] 243090011756 heme pocket [chemical binding]; other site 243090011757 PAS domain S-box; Region: sensory_box; TIGR00229 243090011758 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090011759 putative active site [active] 243090011760 heme pocket [chemical binding]; other site 243090011761 PAS fold; Region: PAS_3; pfam08447 243090011762 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090011763 putative active site [active] 243090011764 heme pocket [chemical binding]; other site 243090011765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090011766 dimer interface [polypeptide binding]; other site 243090011767 phosphorylation site [posttranslational modification] 243090011768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090011769 ATP binding site [chemical binding]; other site 243090011770 Mg2+ binding site [ion binding]; other site 243090011771 G-X-G motif; other site 243090011772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090011773 active site 243090011774 phosphorylation site [posttranslational modification] 243090011775 intermolecular recognition site; other site 243090011776 dimerization interface [polypeptide binding]; other site 243090011777 CsbD-like; Region: CsbD; cl17424 243090011778 Cupin domain; Region: Cupin_2; cl17218 243090011779 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 243090011780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090011781 Coenzyme A binding pocket [chemical binding]; other site 243090011782 TPR repeat; Region: TPR_11; pfam13414 243090011783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090011784 binding surface 243090011785 TPR motif; other site 243090011786 cosmid pircos-b1g07/ cosmid pircos-b2h03 joining point 243090011787 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 243090011788 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 243090011789 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 243090011790 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 243090011791 Predicted membrane protein [Function unknown]; Region: COG4270 243090011792 ZIP Zinc transporter; Region: Zip; cl00437 243090011793 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 243090011794 Prostaglandin dehydrogenases; Region: PGDH; cd05288 243090011795 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 243090011796 NAD(P) binding site [chemical binding]; other site 243090011797 substrate binding site [chemical binding]; other site 243090011798 dimer interface [polypeptide binding]; other site 243090011799 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 243090011800 NAD(P) binding site [chemical binding]; other site 243090011801 catalytic residues [active] 243090011802 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 243090011803 classical (c) SDRs; Region: SDR_c; cd05233 243090011804 NAD(P) binding site [chemical binding]; other site 243090011805 active site 243090011806 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 243090011807 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 243090011808 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 243090011809 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243090011810 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 243090011811 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090011812 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243090011813 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 243090011814 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243090011815 Zn2+ binding site [ion binding]; other site 243090011816 Mg2+ binding site [ion binding]; other site 243090011817 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 243090011818 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 243090011819 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 243090011820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090011821 Coenzyme A binding pocket [chemical binding]; other site 243090011822 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243090011823 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 243090011824 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 243090011825 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090011826 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090011827 DNA binding residues [nucleotide binding] 243090011828 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090011829 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090011830 active site 243090011831 ATP binding site [chemical binding]; other site 243090011832 substrate binding site [chemical binding]; other site 243090011833 activation loop (A-loop); other site 243090011834 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 243090011835 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 243090011836 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 243090011837 homodimer interface [polypeptide binding]; other site 243090011838 active site 243090011839 TDP-binding site; other site 243090011840 acceptor substrate-binding pocket; other site 243090011841 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243090011842 BNR repeat-like domain; Region: BNR_2; pfam13088 243090011843 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 243090011844 Asp-box motif; other site 243090011845 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 243090011846 putative metal binding residues [ion binding]; other site 243090011847 signature motif; other site 243090011848 dimer interface [polypeptide binding]; other site 243090011849 active site 243090011850 polyP binding site; other site 243090011851 substrate binding site [chemical binding]; other site 243090011852 acceptor-phosphate pocket; other site 243090011853 CotH protein; Region: CotH; cl19892 243090011854 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090011855 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090011856 Flavodoxin; Region: Flavodoxin_1; pfam00258 243090011857 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 243090011858 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 243090011859 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 243090011860 PepSY-associated TM helix; Region: PepSY_TM_1; cl19400 243090011861 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090011862 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090011863 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090011864 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090011865 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090011866 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090011867 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243090011868 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243090011869 Walker A/P-loop; other site 243090011870 ATP binding site [chemical binding]; other site 243090011871 Q-loop/lid; other site 243090011872 ABC transporter signature motif; other site 243090011873 Walker B; other site 243090011874 D-loop; other site 243090011875 H-loop/switch region; other site 243090011876 cosmid pircos-b2h03/ cosmid pircos-b3b02 joining point 243090011877 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 243090011878 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 243090011879 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 243090011880 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 243090011881 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243090011882 FtsX-like permease family; Region: FtsX; pfam02687 243090011883 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243090011884 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 243090011885 FtsX-like permease family; Region: FtsX; pfam02687 243090011886 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243090011887 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243090011888 Walker A/P-loop; other site 243090011889 ATP binding site [chemical binding]; other site 243090011890 Q-loop/lid; other site 243090011891 ABC transporter signature motif; other site 243090011892 Walker B; other site 243090011893 D-loop; other site 243090011894 H-loop/switch region; other site 243090011895 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243090011896 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 243090011897 FtsX-like permease family; Region: FtsX; pfam02687 243090011898 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243090011899 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 243090011900 FtsX-like permease family; Region: FtsX; pfam02687 243090011901 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243090011902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090011903 active site 243090011904 phosphorylation site [posttranslational modification] 243090011905 intermolecular recognition site; other site 243090011906 dimerization interface [polypeptide binding]; other site 243090011907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090011908 Walker A motif; other site 243090011909 ATP binding site [chemical binding]; other site 243090011910 Walker B motif; other site 243090011911 arginine finger; other site 243090011912 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243090011913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090011914 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243090011915 dimerization interface [polypeptide binding]; other site 243090011916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090011917 ATP binding site [chemical binding]; other site 243090011918 Mg2+ binding site [ion binding]; other site 243090011919 G-X-G motif; other site 243090011920 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090011921 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090011922 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090011923 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 243090011924 EF-hand domain pair; Region: EF-hand_7; pfam13499 243090011925 Ca2+ binding site [ion binding]; other site 243090011926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243090011927 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 243090011928 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 243090011929 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 243090011930 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 243090011931 Neuregulin family; Region: Neuregulin; pfam02158 243090011932 NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652 243090011933 active site 243090011934 BNR repeat-like domain; Region: BNR_2; pfam13088 243090011935 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 243090011936 Asp-box motif; other site 243090011937 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 243090011938 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 243090011939 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 243090011940 Sulfate transporter family; Region: Sulfate_transp; cl19250 243090011941 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 243090011942 active site clefts [active] 243090011943 zinc binding site [ion binding]; other site 243090011944 dimer interface [polypeptide binding]; other site 243090011945 potassium/proton antiporter; Reviewed; Region: PRK05326 243090011946 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 243090011947 TrkA-C domain; Region: TrkA_C; pfam02080 243090011948 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243090011949 MMPL family; Region: MMPL; cl14618 243090011950 MMPL family; Region: MMPL; cl14618 243090011951 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090011952 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090011953 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243090011954 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243090011955 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 243090011956 Predicted transcriptional regulator [Transcription]; Region: COG1959 243090011957 Rrf2 family protein; Region: rrf2_super; TIGR00738 243090011958 N-acyl-L-amino-acid amidohydrolase; Region: Ac-peptdase-euk; TIGR01880 243090011959 cosmid pircos-b3b02/ cosmid pircos-b1h04 joining point 243090011960 Acyltransferase family; Region: Acyl_transf_3; cl19154 243090011961 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 243090011962 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090011963 Type III pantothenate kinase; Region: Pan_kinase; cl17198 243090011964 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243090011965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090011966 binding surface 243090011967 TPR motif; other site 243090011968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090011969 binding surface 243090011970 TPR motif; other site 243090011971 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090011972 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090011973 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090011974 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090011975 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 243090011976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090011977 active site 243090011978 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 243090011979 phosphorylation site [posttranslational modification] 243090011980 intermolecular recognition site; other site 243090011981 dimerization interface [polypeptide binding]; other site 243090011982 PAS fold; Region: PAS_4; pfam08448 243090011983 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090011984 putative active site [active] 243090011985 heme pocket [chemical binding]; other site 243090011986 PAS domain; Region: PAS_9; pfam13426 243090011987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090011988 dimer interface [polypeptide binding]; other site 243090011989 phosphorylation site [posttranslational modification] 243090011990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090011991 ATP binding site [chemical binding]; other site 243090011992 Mg2+ binding site [ion binding]; other site 243090011993 G-X-G motif; other site 243090011994 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243090011995 Uncharacterized conserved protein [Function unknown]; Region: COG2966 243090011996 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 243090011997 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 243090011998 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 243090011999 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 243090012000 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 243090012001 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090012002 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090012003 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090012004 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 243090012005 putative catalytic site [active] 243090012006 putative metal binding site [ion binding]; other site 243090012007 putative phosphate binding site [ion binding]; other site 243090012008 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 243090012009 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 243090012010 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 243090012011 dimer interface [polypeptide binding]; other site 243090012012 putative tRNA-binding site [nucleotide binding]; other site 243090012013 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090012014 Sulfatase; Region: Sulfatase; pfam00884 243090012015 cosmid pircos-b1h04/ cosmid pircos-c2f09 joining point 243090012016 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 243090012017 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 243090012018 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 243090012019 active site 243090012020 Bacterial SH3 domain; Region: SH3_3; pfam08239 243090012021 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243090012022 NlpC/P60 family; Region: NLPC_P60; pfam00877 243090012023 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 243090012024 Protein of unknown function (DUF1586); Region: DUF1586; pfam07625 243090012025 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090012026 Sulfatase; Region: Sulfatase; pfam00884 243090012027 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090012028 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090012029 Sulfatase; Region: Sulfatase; pfam00884 243090012030 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090012031 Animal haem peroxidase; Region: An_peroxidase; pfam03098 243090012032 Uncharacterized family of heme peroxidases, mostly bacterial; Region: peroxinectin_like_bacterial; cd09822 243090012033 putative heme binding site [chemical binding]; other site 243090012034 putative substrate binding site [chemical binding]; other site 243090012035 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090012036 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090012037 Matrixin; Region: Peptidase_M10; pfam00413 243090012038 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 243090012039 active site 243090012040 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090012041 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 243090012042 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090012043 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090012044 DNA binding residues [nucleotide binding] 243090012045 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090012046 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090012047 active site 243090012048 ATP binding site [chemical binding]; other site 243090012049 substrate binding site [chemical binding]; other site 243090012050 activation loop (A-loop); other site 243090012051 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090012052 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090012053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090012054 binding surface 243090012055 TPR motif; other site 243090012056 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090012057 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090012058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090012059 binding surface 243090012060 TPR motif; other site 243090012061 PQQ-like domain; Region: PQQ_2; pfam13360 243090012062 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090012063 Trp docking motif [polypeptide binding]; other site 243090012064 active site 243090012065 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 243090012066 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 243090012067 Low molecular weight phosphatase family; Region: LMWPc; cl00105 243090012068 active site 243090012069 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 243090012070 FMN binding site [chemical binding]; other site 243090012071 active site 243090012072 substrate binding site [chemical binding]; other site 243090012073 catalytic residue [active] 243090012074 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 243090012075 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 243090012076 putative NAD(P) binding site [chemical binding]; other site 243090012077 putative substrate binding site [chemical binding]; other site 243090012078 catalytic Zn binding site [ion binding]; other site 243090012079 structural Zn binding site [ion binding]; other site 243090012080 dimer interface [polypeptide binding]; other site 243090012081 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243090012082 MMPL family; Region: MMPL; cl14618 243090012083 MMPL family; Region: MMPL; cl14618 243090012084 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090012085 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243090012086 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090012087 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243090012088 Outer membrane efflux protein; Region: OEP; pfam02321 243090012089 Outer membrane efflux protein; Region: OEP; pfam02321 243090012090 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090012091 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090012092 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090012093 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 243090012094 catalytic residues [active] 243090012095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243090012096 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243090012097 NAD(P) binding site [chemical binding]; other site 243090012098 active site 243090012099 Putative peptidase family; Region: Metallopep; pfam12044 243090012100 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 243090012101 cosmid pircos-c2f09/ cosmid pircos-d2g06 joining point 243090012102 Cytochrome c7; Region: Cytochrome_C7; cl19206 243090012103 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 243090012104 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 243090012105 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243090012106 active site residue [active] 243090012107 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 243090012108 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 243090012109 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 243090012110 CoA binding domain; Region: CoA_binding_2; pfam13380 243090012111 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 243090012112 Rhodanese-like domain; Region: Rhodanese; pfam00581 243090012113 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243090012114 active site residue [active] 243090012115 Putative phosphatase (DUF442); Region: DUF442; cl17385 243090012116 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243090012117 Ligand Binding Site [chemical binding]; other site 243090012118 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243090012119 Ligand Binding Site [chemical binding]; other site 243090012120 Protein of unknown function (DUF1586); Region: DUF1586; pfam07625 243090012121 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243090012122 Ligand Binding Site [chemical binding]; other site 243090012123 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243090012124 Ligand Binding Site [chemical binding]; other site 243090012125 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243090012126 Ligand Binding Site [chemical binding]; other site 243090012127 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243090012128 Ligand Binding Site [chemical binding]; other site 243090012129 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243090012130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090012131 active site 243090012132 phosphorylation site [posttranslational modification] 243090012133 intermolecular recognition site; other site 243090012134 dimerization interface [polypeptide binding]; other site 243090012135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090012136 Walker A motif; other site 243090012137 ATP binding site [chemical binding]; other site 243090012138 Walker B motif; other site 243090012139 arginine finger; other site 243090012140 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243090012141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090012142 active site 243090012143 phosphorylation site [posttranslational modification] 243090012144 intermolecular recognition site; other site 243090012145 dimerization interface [polypeptide binding]; other site 243090012146 PAS domain S-box; Region: sensory_box; TIGR00229 243090012147 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090012148 putative active site [active] 243090012149 heme pocket [chemical binding]; other site 243090012150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090012151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090012152 dimer interface [polypeptide binding]; other site 243090012153 phosphorylation site [posttranslational modification] 243090012154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090012155 ATP binding site [chemical binding]; other site 243090012156 Mg2+ binding site [ion binding]; other site 243090012157 G-X-G motif; other site 243090012158 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 243090012159 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 243090012160 PhnA protein; Region: PhnA; pfam03831 243090012161 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 243090012162 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 243090012163 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090012164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090012165 active site 243090012166 phosphorylation site [posttranslational modification] 243090012167 intermolecular recognition site; other site 243090012168 dimerization interface [polypeptide binding]; other site 243090012169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090012170 putative active site [active] 243090012171 PAS fold; Region: PAS_3; pfam08447 243090012172 heme pocket [chemical binding]; other site 243090012173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090012174 dimer interface [polypeptide binding]; other site 243090012175 phosphorylation site [posttranslational modification] 243090012176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090012177 ATP binding site [chemical binding]; other site 243090012178 Mg2+ binding site [ion binding]; other site 243090012179 G-X-G motif; other site 243090012180 mercuric reductase; Validated; Region: PRK06370 243090012181 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243090012182 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 243090012183 Uncharacterized conserved protein [Function unknown]; Region: COG0398 243090012184 Protein of unknown function, DUF547; Region: DUF547; pfam04784 243090012185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090012186 Coenzyme A binding pocket [chemical binding]; other site 243090012187 Ferredoxin [Energy production and conversion]; Region: COG1146 243090012188 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243090012189 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 243090012190 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 243090012191 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243090012192 dimerization interface [polypeptide binding]; other site 243090012193 putative DNA binding site [nucleotide binding]; other site 243090012194 putative Zn2+ binding site [ion binding]; other site 243090012195 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243090012196 active site residue [active] 243090012197 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 243090012198 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243090012199 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 243090012200 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 243090012201 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 243090012202 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243090012203 active site residue [active] 243090012204 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 243090012205 Ferritin-like domain; Region: Ferritin; pfam00210 243090012206 heme binding site [chemical binding]; other site 243090012207 ferroxidase pore; other site 243090012208 ferroxidase diiron center [ion binding]; other site 243090012209 DsrE/DsrF-like family; Region: DrsE; pfam02635 243090012210 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 243090012211 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 243090012212 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 243090012213 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090012214 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243090012215 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 243090012216 cosmid pircos-d2g06/ cosmid pircos-c2f02 joining point 243090012217 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090012218 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090012219 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090012220 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090012221 active site 243090012222 ATP binding site [chemical binding]; other site 243090012223 substrate binding site [chemical binding]; other site 243090012224 activation loop (A-loop); other site 243090012225 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 243090012226 Predicted ATPase [General function prediction only]; Region: COG4637 243090012227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 243090012228 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090012229 Walker A motif; other site 243090012230 Walker A/P-loop; other site 243090012231 ATP binding site [chemical binding]; other site 243090012232 ATP binding site [chemical binding]; other site 243090012233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 243090012234 Walker B; other site 243090012235 D-loop; other site 243090012236 H-loop/switch region; other site 243090012237 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 243090012238 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 243090012239 active site 243090012240 catalytic triad [active] 243090012241 oxyanion hole [active] 243090012242 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 243090012243 Cytochrome P450; Region: p450; cl12078 243090012244 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 243090012245 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 243090012246 Uncharacterized conserved protein [Function unknown]; Region: COG0398 243090012247 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 243090012248 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 243090012249 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 243090012250 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 243090012251 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 243090012252 putative active site [active] 243090012253 putative metal binding site [ion binding]; other site 243090012254 Cytochrome c [Energy production and conversion]; Region: COG3258 243090012255 Cytochrome c; Region: Cytochrom_C; pfam00034 243090012256 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 243090012257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243090012258 putative substrate translocation pore; other site 243090012259 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243090012260 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090012261 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090012262 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 243090012263 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090012264 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090012265 TspO/MBR family; Region: TspO_MBR; pfam03073 243090012266 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 243090012267 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 243090012268 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243090012269 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 243090012270 cosmid pircos-c2f02/ cosmid pircos-a4a11 joining point 243090012271 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 243090012272 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 243090012273 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 243090012274 AAA ATPase domain; Region: AAA_16; pfam13191 243090012275 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 243090012276 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 243090012277 nudix motif; other site 243090012278 TIR domain; Region: TIR_2; pfam13676 243090012279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 243090012280 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090012281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090012282 binding surface 243090012283 TPR motif; other site 243090012284 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090012285 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090012286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090012287 binding surface 243090012288 TPR motif; other site 243090012289 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243090012290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243090012291 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243090012292 dimerization interface [polypeptide binding]; other site 243090012293 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 243090012294 TrkA-N domain; Region: TrkA_N; pfam02254 243090012295 RyR domain; Region: RyR; pfam02026 243090012296 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 243090012297 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090012298 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090012299 active site 243090012300 ATP binding site [chemical binding]; other site 243090012301 substrate binding site [chemical binding]; other site 243090012302 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090012303 substrate binding site [chemical binding]; other site 243090012304 activation loop (A-loop); other site 243090012305 activation loop (A-loop); other site 243090012306 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090012307 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243090012308 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243090012309 structural tetrad; other site 243090012310 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090012311 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243090012312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090012313 binding surface 243090012314 TPR motif; other site 243090012315 cosmid pircos-a4a11/ cosmid pircos-a1h09 joining point 243090012316 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 243090012317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 243090012318 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243090012319 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243090012320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 243090012321 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243090012322 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 243090012323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090012324 FeS/SAM binding site; other site 243090012325 guanine deaminase; Region: guan_deamin; TIGR02967 243090012326 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243090012327 active site 243090012328 Domain of unknown function (DUF955); Region: DUF955; pfam06114 243090012329 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243090012330 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243090012331 non-specific DNA binding site [nucleotide binding]; other site 243090012332 salt bridge; other site 243090012333 sequence-specific DNA binding site [nucleotide binding]; other site 243090012334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090012335 binding surface 243090012336 TPR motif; other site 243090012337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090012338 binding surface 243090012339 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 243090012340 TPR motif; other site 243090012341 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243090012342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243090012343 non-specific DNA binding site [nucleotide binding]; other site 243090012344 salt bridge; other site 243090012345 sequence-specific DNA binding site [nucleotide binding]; other site 243090012346 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 243090012347 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 243090012348 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090012349 ATP binding site [chemical binding]; other site 243090012350 putative Mg++ binding site [ion binding]; other site 243090012351 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 243090012352 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243090012353 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243090012354 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243090012355 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 243090012356 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243090012357 Methyltransferase domain; Region: Methyltransf_26; pfam13659 243090012358 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 243090012359 DNA binding residues [nucleotide binding] 243090012360 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 243090012361 Predicted membrane protein [Function unknown]; Region: COG4270 243090012362 PIN domain; Region: PIN_3; pfam13470 243090012363 HicB family; Region: HicB; pfam05534 243090012364 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 243090012365 TspO/MBR family; Region: TspO_MBR; pfam03073 243090012366 SOUL heme-binding protein; Region: SOUL; pfam04832 243090012367 Protein of unknown function, DUF393; Region: DUF393; pfam04134 243090012368 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 243090012369 PLD-like domain; Region: PLDc_2; pfam13091 243090012370 putative homodimer interface [polypeptide binding]; other site 243090012371 putative active site [active] 243090012372 catalytic site [active] 243090012373 DEAD-like helicases superfamily; Region: DEXDc; smart00487 243090012374 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090012375 ATP binding site [chemical binding]; other site 243090012376 putative Mg++ binding site [ion binding]; other site 243090012377 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090012378 nucleotide binding region [chemical binding]; other site 243090012379 ATP-binding site [chemical binding]; other site 243090012380 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 243090012381 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243090012382 active site 243090012383 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 243090012384 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 243090012385 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090012386 ATP binding site [chemical binding]; other site 243090012387 putative Mg++ binding site [ion binding]; other site 243090012388 cosmid pircos-a1h09/ cosmid pircos-c2a08 joining point 243090012389 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 243090012390 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243090012391 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243090012392 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243090012393 AAA domain; Region: AAA_21; pfam13304 243090012394 AAA domain; Region: AAA_21; pfam13304 243090012395 Cupin domain; Region: Cupin_2; cl17218 243090012396 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 243090012397 Active_site [active] 243090012398 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243090012399 TROVE domain; Region: TROVE; pfam05731 243090012400 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243090012401 metal ion-dependent adhesion site (MIDAS); other site 243090012402 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 243090012403 SEC-C motif; Region: SEC-C; cl19389 243090012404 cosmid pircos-c2a08/ cosmid gap joining point 243090012405 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 243090012406 CoA binding domain; Region: CoA_binding_2; pfam13380 243090012407 PQQ-like domain; Region: PQQ_2; pfam13360 243090012408 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090012409 active site 243090012410 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 243090012411 YHYH protein; Region: YHYH; pfam14240 243090012412 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 243090012413 substrate binding site [chemical binding]; other site 243090012414 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 243090012415 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090012416 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090012417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090012418 Coenzyme A binding pocket [chemical binding]; other site 243090012419 cosmid gap/ cosmid pircos-d3f03 joining point 243090012420 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243090012421 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 243090012422 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243090012423 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 243090012424 YCII-related domain; Region: YCII; cl00999 243090012425 DoxX; Region: DoxX; pfam07681 243090012426 short chain dehydrogenase; Provisional; Region: PRK12937 243090012427 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 243090012428 NADP binding site [chemical binding]; other site 243090012429 homodimer interface [polypeptide binding]; other site 243090012430 active site 243090012431 substrate binding site [chemical binding]; other site 243090012432 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 243090012433 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 243090012434 FAD binding pocket [chemical binding]; other site 243090012435 FAD binding motif [chemical binding]; other site 243090012436 phosphate binding motif [ion binding]; other site 243090012437 NAD binding pocket [chemical binding]; other site 243090012438 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 243090012439 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 243090012440 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 243090012441 NADP binding site [chemical binding]; other site 243090012442 Histidine-specific methyltransferase, SAM-dependent; Region: Methyltransf_33; pfam10017 243090012443 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 243090012444 DinB superfamily; Region: DinB_2; pfam12867 243090012445 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 243090012446 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243090012447 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 243090012448 Maltose acetyltransferase; Region: Mac; pfam12464 243090012449 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 243090012450 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 243090012451 active site 1 [active] 243090012452 dimer interface [polypeptide binding]; other site 243090012453 hexamer interface [polypeptide binding]; other site 243090012454 active site 2 [active] 243090012455 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 243090012456 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 243090012457 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 243090012458 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 243090012459 dimer interface [polypeptide binding]; other site 243090012460 putative tRNA-binding site [nucleotide binding]; other site 243090012461 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 243090012462 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 243090012463 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 243090012464 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 243090012465 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243090012466 Zn2+ binding site [ion binding]; other site 243090012467 Mg2+ binding site [ion binding]; other site 243090012468 A new structural DNA glycosylase; Region: AlkD_like; cd06561 243090012469 active site 243090012470 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243090012471 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 243090012472 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090012473 FeS/SAM binding site; other site 243090012474 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243090012475 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243090012476 active site 243090012477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243090012478 active site 243090012479 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 243090012480 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 243090012481 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 243090012482 dimer interface [polypeptide binding]; other site 243090012483 FMN binding site [chemical binding]; other site 243090012484 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090012485 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090012486 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243090012487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243090012488 Walker A/P-loop; other site 243090012489 ATP binding site [chemical binding]; other site 243090012490 Q-loop/lid; other site 243090012491 ABC transporter signature motif; other site 243090012492 Walker B; other site 243090012493 D-loop; other site 243090012494 H-loop/switch region; other site 243090012495 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 243090012496 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243090012497 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090012498 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090012499 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 243090012500 cosmid pircos-d3f03/ cosmid pircos-c3g03 joining point 243090012501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090012502 Walker A motif; other site 243090012503 ATP binding site [chemical binding]; other site 243090012504 Walker B motif; other site 243090012505 arginine finger; other site 243090012506 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 243090012507 DnaA box-binding interface [nucleotide binding]; other site 243090012508 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 243090012509 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243090012510 catalytic residue [active] 243090012511 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 243090012512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090012513 active site 243090012514 phosphorylation site [posttranslational modification] 243090012515 intermolecular recognition site; other site 243090012516 dimerization interface [polypeptide binding]; other site 243090012517 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243090012518 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 243090012519 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 243090012520 Walker A motif; other site 243090012521 ATP binding site [chemical binding]; other site 243090012522 Walker B motif; other site 243090012523 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243090012524 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 243090012525 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243090012526 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 243090012527 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090012528 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243090012529 dimerization interface [polypeptide binding]; other site 243090012530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090012531 dimer interface [polypeptide binding]; other site 243090012532 phosphorylation site [posttranslational modification] 243090012533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090012534 ATP binding site [chemical binding]; other site 243090012535 Mg2+ binding site [ion binding]; other site 243090012536 G-X-G motif; other site 243090012537 SLA1 homology domain 1, SHD1; Region: SHD1; pfam03983 243090012538 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 243090012539 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 243090012540 active site 243090012541 catalytic residues [active] 243090012542 DNA binding site [nucleotide binding] 243090012543 Int/Topo IB signature motif; other site 243090012544 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 243090012545 GIY-YIG motif/motif A; other site 243090012546 putative active site [active] 243090012547 putative metal binding site [ion binding]; other site 243090012548 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 243090012549 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 243090012550 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243090012551 Methyltransferase domain; Region: Methyltransf_26; pfam13659 243090012552 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243090012553 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243090012554 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243090012555 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 243090012556 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 243090012557 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 243090012558 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090012559 ATP binding site [chemical binding]; other site 243090012560 putative Mg++ binding site [ion binding]; other site 243090012561 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090012562 nucleotide binding region [chemical binding]; other site 243090012563 ATP-binding site [chemical binding]; other site 243090012564 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 243090012565 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 243090012566 SEC-C motif; Region: SEC-C; pfam02810 243090012567 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 243090012568 cosmid pircos-c3g03/ cosmid pircos-a1h07 joining point 243090012569 Protein of unknown function (DUF1580); Region: DUF1580; pfam07618 243090012570 Spumavirus gag protein; Region: Gag_spuma; pfam03276 243090012571 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 243090012572 GIY-YIG motif/motif A; other site 243090012573 putative active site [active] 243090012574 putative metal binding site [ion binding]; other site 243090012575 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 243090012576 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 243090012577 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243090012578 Methyltransferase domain; Region: Methyltransf_26; pfam13659 243090012579 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243090012580 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243090012581 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243090012582 GET complex subunit GET2; Region: GET2; pfam08690 243090012583 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090012584 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090012585 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_3; cd06237 243090012586 putative active site [active] 243090012587 Zn binding site [ion binding]; other site 243090012588 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090012589 Trp docking motif [polypeptide binding]; other site 243090012590 active site 243090012591 PQQ-like domain; Region: PQQ_2; pfam13360 243090012592 benzoate transport; Region: 2A0115; TIGR00895 243090012593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243090012594 putative substrate translocation pore; other site 243090012595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090012596 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090012597 dimer interface [polypeptide binding]; other site 243090012598 phosphorylation site [posttranslational modification] 243090012599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090012600 ATP binding site [chemical binding]; other site 243090012601 Mg2+ binding site [ion binding]; other site 243090012602 G-X-G motif; other site 243090012603 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243090012604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090012605 active site 243090012606 phosphorylation site [posttranslational modification] 243090012607 intermolecular recognition site; other site 243090012608 dimerization interface [polypeptide binding]; other site 243090012609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090012610 Walker A motif; other site 243090012611 ATP binding site [chemical binding]; other site 243090012612 Walker B motif; other site 243090012613 arginine finger; other site 243090012614 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243090012615 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 243090012616 Putative esterase; Region: Esterase; pfam00756 243090012617 GTP-binding protein LepA; Provisional; Region: PRK05433 243090012618 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 243090012619 G1 box; other site 243090012620 putative GEF interaction site [polypeptide binding]; other site 243090012621 GTP/Mg2+ binding site [chemical binding]; other site 243090012622 Switch I region; other site 243090012623 G2 box; other site 243090012624 G3 box; other site 243090012625 Switch II region; other site 243090012626 G4 box; other site 243090012627 G5 box; other site 243090012628 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 243090012629 Elongation Factor G, domain II; Region: EFG_II; pfam14492 243090012630 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 243090012631 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 243090012632 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 243090012633 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 243090012634 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 243090012635 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 243090012636 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 243090012637 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 243090012638 SEC-C motif; Region: SEC-C; pfam02810 243090012639 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 243090012640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090012641 binding surface 243090012642 TPR repeat; Region: TPR_11; pfam13414 243090012643 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243090012644 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090012645 binding surface 243090012646 TPR motif; other site 243090012647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090012648 TPR motif; other site 243090012649 binding surface 243090012650 cosmid pircos-a1h07/ cosmid pircos-a2f07 joining point 243090012651 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 243090012652 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090012653 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090012654 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 243090012655 protein binding site [polypeptide binding]; other site 243090012656 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 243090012657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090012658 ATP binding site [chemical binding]; other site 243090012659 putative Mg++ binding site [ion binding]; other site 243090012660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090012661 nucleotide binding region [chemical binding]; other site 243090012662 ATP-binding site [chemical binding]; other site 243090012663 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 243090012664 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090012665 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090012666 NRDE protein; Region: NRDE; cl01315 243090012667 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090012668 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090012669 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090012670 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090012671 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090012672 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090012673 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090012674 Transposase; Region: HTH_Tnp_1; cl17663 243090012675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 243090012676 putative transposase OrfB; Reviewed; Region: PHA02517 243090012677 HTH-like domain; Region: HTH_21; pfam13276 243090012678 Integrase core domain; Region: rve; pfam00665 243090012679 Integrase core domain; Region: rve_3; pfam13683 243090012680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090012681 S-adenosylmethionine binding site [chemical binding]; other site 243090012682 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 243090012683 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090012684 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090012685 Calx-beta domain; Region: Calx-beta; cl02522 243090012686 Calx-beta domain; Region: Calx-beta; cl02522 243090012687 Calx-beta domain; Region: Calx-beta; cl02522 243090012688 Calx-beta domain; Region: Calx-beta; cl02522 243090012689 Calx-beta domain; Region: Calx-beta; cl02522 243090012690 Calx-beta domain; Region: Calx-beta; cl02522 243090012691 Calx-beta domain; Region: Calx-beta; cl02522 243090012692 Calx-beta domain; Region: Calx-beta; cl02522 243090012693 Calx-beta domain; Region: Calx-beta; cl02522 243090012694 Calx-beta domain; Region: Calx-beta; cl02522 243090012695 Calx-beta domain; Region: Calx-beta; cl02522 243090012696 Calx-beta domain; Region: Calx-beta; cl02522 243090012697 Calx-beta domain; Region: Calx-beta; cl02522 243090012698 Calx-beta domain; Region: Calx-beta; cl02522 243090012699 Calx-beta domain; Region: Calx-beta; cl02522 243090012700 Calx-beta domain; Region: Calx-beta; cl02522 243090012701 Calx-beta domain; Region: Calx-beta; cl02522 243090012702 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243090012703 Ca2+ binding site [ion binding]; other site 243090012704 cosmid pircos-a2f07/ cosmid pircos-a3b11 joining point 243090012705 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 243090012706 surface protease GP63; Provisional; Region: PTZ00337 243090012707 active site 243090012708 PEP-CTERM motif; Region: VPEP; pfam07589 243090012709 Transposase; Region: HTH_Tnp_1; cl17663 243090012710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 243090012711 putative transposase OrfB; Reviewed; Region: PHA02517 243090012712 HTH-like domain; Region: HTH_21; pfam13276 243090012713 Integrase core domain; Region: rve; pfam00665 243090012714 Integrase core domain; Region: rve_3; pfam13683 243090012715 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 243090012716 active site 243090012717 PEP-CTERM motif; Region: VPEP; pfam07589 243090012718 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 243090012719 Uncharacterized conserved protein [Function unknown]; Region: COG1262 243090012720 Protein of unknown function (DUF1582); Region: DUF1582; pfam07621 243090012721 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 243090012722 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 243090012723 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 243090012724 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 243090012725 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 243090012726 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 243090012727 active site 243090012728 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 243090012729 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 243090012730 transcriptional regulator ICP4; Provisional; Region: PHA03307 243090012731 hypothetical protein; Provisional; Region: PRK11281 243090012732 Nucleoside diphosphate kinase; Region: NDK; pfam00334 243090012733 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 243090012734 active site 243090012735 multimer interface [polypeptide binding]; other site 243090012736 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243090012737 active site 243090012738 Protein of unknown function (DUF1589); Region: DUF1589; pfam07628 243090012739 Protein of unknown function (DUF1589); Region: DUF1589; pfam07628 243090012740 methionine sulfoxide reductase A; Provisional; Region: PRK14054 243090012741 Protein of unknown function (DUF1582); Region: DUF1582; pfam07621 243090012742 Protein of unknown function (DUF1584); Region: PEGSRP; pfam07623 243090012743 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243090012744 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243090012745 GTP cyclohydrolase I; Region: GTP_cyclohydroI; pfam01227 243090012746 active site 243090012747 cosmid pircos-a3b11/ cosmid pircos-c4a07 joining point 243090012748 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 243090012749 Na binding site [ion binding]; other site 243090012750 Protein of unknown function, DUF485; Region: DUF485; pfam04341 243090012751 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 243090012752 recombinase A; Provisional; Region: recA; PRK09354 243090012753 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 243090012754 hexamer interface [polypeptide binding]; other site 243090012755 Walker A motif; other site 243090012756 ATP binding site [chemical binding]; other site 243090012757 Walker B motif; other site 243090012758 HDOD domain; Region: HDOD; pfam08668 243090012759 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 243090012760 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 243090012761 Sulfite exporter TauE/SafE; Region: TauE; cl19196 243090012762 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 243090012763 DsbD alpha interface [polypeptide binding]; other site 243090012764 catalytic residues [active] 243090012765 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 243090012766 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 243090012767 trmE is a tRNA modification GTPase; Region: trmE; cd04164 243090012768 G1 box; other site 243090012769 GTP/Mg2+ binding site [chemical binding]; other site 243090012770 Switch I region; other site 243090012771 G2 box; other site 243090012772 Switch II region; other site 243090012773 G3 box; other site 243090012774 G4 box; other site 243090012775 G5 box; other site 243090012776 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 243090012777 methionine sulfoxide reductase A; Provisional; Region: PRK14054 243090012778 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 243090012779 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090012780 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090012781 protein binding site [polypeptide binding]; other site 243090012782 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 243090012783 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 243090012784 active site 243090012785 catalytic motif [active] 243090012786 Zn binding site [ion binding]; other site 243090012787 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090012788 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090012789 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090012790 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090012791 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090012792 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090012793 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090012794 DNA Polymerase Y-family; Region: PolY_like; cd03468 243090012795 active site 243090012796 DNA binding site [nucleotide binding] 243090012797 Uncharacterized conserved protein [Function unknown]; Region: COG4544 243090012798 cosmid pircos-c4a07/ cosmid pircos-a1c03 joining point 243090012799 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 243090012800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243090012801 Coenzyme A binding pocket [chemical binding]; other site 243090012802 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 243090012803 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 243090012804 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 243090012805 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090012806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090012807 Walker A motif; other site 243090012808 ATP binding site [chemical binding]; other site 243090012809 Walker B motif; other site 243090012810 arginine finger; other site 243090012811 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243090012812 Protein of unknown function DUF58; Region: DUF58; pfam01882 243090012813 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243090012814 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243090012815 Protein of unknown function (DUF971); Region: DUF971; pfam06155 243090012816 putative dehydratase; Provisional; Region: PRK08211 243090012817 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 243090012818 Protein of unknown function (DUF420); Region: DUF420; pfam04238 243090012819 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 243090012820 Cu(I) binding site [ion binding]; other site 243090012821 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090012822 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243090012823 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 243090012824 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243090012825 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243090012826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243090012827 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 243090012828 Walker A/P-loop; other site 243090012829 ATP binding site [chemical binding]; other site 243090012830 Q-loop/lid; other site 243090012831 ABC transporter signature motif; other site 243090012832 Walker B; other site 243090012833 D-loop; other site 243090012834 H-loop/switch region; other site 243090012835 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 243090012836 putative active site [active] 243090012837 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl19388 243090012838 Cytochrome c; Region: Cytochrom_C; pfam00034 243090012839 Cytochrome c; Region: Cytochrom_C; pfam00034 243090012840 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 243090012841 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 243090012842 DXD motif; other site 243090012843 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 243090012844 putative acyl-acceptor binding pocket; other site 243090012845 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243090012846 phytoene desaturase; Region: crtI_fam; TIGR02734 243090012847 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090012848 aldehyde dehydrogenase family 2 member; Region: PLN02466 243090012849 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243090012850 NAD(P) binding site [chemical binding]; other site 243090012851 catalytic residues [active] 243090012852 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 243090012853 putative FMN binding site [chemical binding]; other site 243090012854 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 243090012855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090012856 Walker A motif; other site 243090012857 ATP binding site [chemical binding]; other site 243090012858 Walker B motif; other site 243090012859 arginine finger; other site 243090012860 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243090012861 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 243090012862 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 243090012863 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090012864 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090012865 active site 243090012866 ATP binding site [chemical binding]; other site 243090012867 substrate binding site [chemical binding]; other site 243090012868 activation loop (A-loop); other site 243090012869 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 243090012870 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 243090012871 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 243090012872 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 243090012873 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 243090012874 cosmid pircos-a1c03/ cosmid pircos-a1h08 joining point 243090012875 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 243090012876 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243090012877 active site 243090012878 ATP-grasp domain; Region: ATP-grasp_3; pfam02655 243090012879 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 243090012880 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243090012881 active site 243090012882 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243090012883 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 243090012884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243090012885 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 243090012886 Enoylreductase; Region: PKS_ER; smart00829 243090012887 NAD(P) binding site [chemical binding]; other site 243090012888 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 243090012889 short chain dehydrogenase; Region: adh_short; pfam00106 243090012890 putative NADP binding site [chemical binding]; other site 243090012891 active site 243090012892 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243090012893 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243090012894 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243090012895 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090012896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090012897 active site 243090012898 phosphorylation site [posttranslational modification] 243090012899 intermolecular recognition site; other site 243090012900 dimerization interface [polypeptide binding]; other site 243090012901 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243090012902 DNA binding site [nucleotide binding] 243090012903 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 243090012904 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 243090012905 Putative esterase; Region: Esterase; pfam00756 243090012906 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 243090012907 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 243090012908 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243090012909 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 243090012910 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 243090012911 cobalamin binding residues [chemical binding]; other site 243090012912 putative BtuC binding residues; other site 243090012913 dimer interface [polypeptide binding]; other site 243090012914 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 243090012915 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 243090012916 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 243090012917 NAD(P) binding site [chemical binding]; other site 243090012918 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243090012919 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243090012920 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090012921 putative active site [active] 243090012922 heme pocket [chemical binding]; other site 243090012923 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090012924 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090012925 putative active site [active] 243090012926 heme pocket [chemical binding]; other site 243090012927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090012928 dimer interface [polypeptide binding]; other site 243090012929 phosphorylation site [posttranslational modification] 243090012930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090012931 ATP binding site [chemical binding]; other site 243090012932 Mg2+ binding site [ion binding]; other site 243090012933 G-X-G motif; other site 243090012934 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243090012935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090012936 active site 243090012937 phosphorylation site [posttranslational modification] 243090012938 intermolecular recognition site; other site 243090012939 dimerization interface [polypeptide binding]; other site 243090012940 Hpt domain; Region: Hpt; pfam01627 243090012941 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090012942 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090012943 active site 243090012944 ATP binding site [chemical binding]; other site 243090012945 substrate binding site [chemical binding]; other site 243090012946 activation loop (A-loop); other site 243090012947 ECF sigma factor; Region: Sigma70_ECF; pfam07638 243090012948 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090012949 DNA binding residues [nucleotide binding] 243090012950 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 243090012951 putative active site [active] 243090012952 Zn binding site [ion binding]; other site 243090012953 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 243090012954 gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530 243090012955 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 243090012956 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 243090012957 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 243090012958 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 243090012959 Leucine-rich repeats; other site 243090012960 Substrate binding site [chemical binding]; other site 243090012961 DNA photolyase; Region: DNA_photolyase; pfam00875 243090012962 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 243090012963 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 243090012964 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 243090012965 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 243090012966 N- and C-terminal domain interface [polypeptide binding]; other site 243090012967 D-xylulose kinase; Region: XylB; TIGR01312 243090012968 active site 243090012969 MgATP binding site [chemical binding]; other site 243090012970 catalytic site [active] 243090012971 metal binding site [ion binding]; metal-binding site 243090012972 xylulose binding site [chemical binding]; other site 243090012973 homodimer interface [polypeptide binding]; other site 243090012974 gamma-glutamyl kinase; Provisional; Region: PRK05429 243090012975 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 243090012976 nucleotide binding site [chemical binding]; other site 243090012977 homotetrameric interface [polypeptide binding]; other site 243090012978 putative phosphate binding site [ion binding]; other site 243090012979 putative allosteric binding site; other site 243090012980 PUA domain; Region: PUA; pfam01472 243090012981 cosmid pircos-a1h08/ cosmid pircos-a1g11 joining point 243090012982 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243090012983 active site 243090012984 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243090012985 active site 243090012986 catalytic tetrad [active] 243090012987 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090012988 Cytochrome c; Region: Cytochrom_C; pfam00034 243090012989 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090012990 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090012991 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090012992 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090012993 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090012994 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090012995 TPR motif; other site 243090012996 binding surface 243090012997 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090012998 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090012999 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090013000 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090013001 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 243090013002 FAD binding domain; Region: FAD_binding_4; pfam01565 243090013003 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 243090013004 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 243090013005 FAD binding domain; Region: FAD_binding_4; cl19922 243090013006 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 243090013007 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243090013008 Cysteine-rich domain; Region: CCG; pfam02754 243090013009 Cysteine-rich domain; Region: CCG; pfam02754 243090013010 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243090013011 DEAD-like helicases superfamily; Region: DEXDc; smart00487 243090013012 ATP binding site [chemical binding]; other site 243090013013 Mg++ binding site [ion binding]; other site 243090013014 motif III; other site 243090013015 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090013016 nucleotide binding region [chemical binding]; other site 243090013017 ATP-binding site [chemical binding]; other site 243090013018 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 243090013019 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090013020 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243090013021 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243090013022 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243090013023 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243090013024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090013025 binding surface 243090013026 TPR motif; other site 243090013027 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243090013028 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 243090013029 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243090013030 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 243090013031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090013032 binding surface 243090013033 TPR motif; other site 243090013034 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243090013035 Tetratricopeptide repeat; Region: TPR_6; pfam13174 243090013036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090013037 binding surface 243090013038 TPR motif; other site 243090013039 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 243090013040 CTP synthetase; Validated; Region: pyrG; PRK05380 243090013041 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 243090013042 Catalytic site [active] 243090013043 active site 243090013044 UTP binding site [chemical binding]; other site 243090013045 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 243090013046 active site 243090013047 putative oxyanion hole; other site 243090013048 catalytic triad [active] 243090013049 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 243090013050 PQQ-like domain; Region: PQQ_2; pfam13360 243090013051 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090013052 Trp docking motif [polypeptide binding]; other site 243090013053 active site 243090013054 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 243090013055 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 243090013056 cosmid pircos-a1g11/ cosmid pircos-a3b08 joining point 243090013057 Planctomycetes uncharacterized domain TIGR03000; Region: plancto_dom_1 243090013058 Planctomycetes uncharacterized domain TIGR03000; Region: plancto_dom_1 243090013059 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243090013060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090013061 S-adenosylmethionine binding site [chemical binding]; other site 243090013062 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 243090013063 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 243090013064 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243090013065 Zn2+ binding site [ion binding]; other site 243090013066 Mg2+ binding site [ion binding]; other site 243090013067 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 243090013068 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 243090013069 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090013070 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 243090013071 arylsulfatase; Provisional; Region: PRK13759 243090013072 Sulfatase; Region: Sulfatase; pfam00884 243090013073 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090013074 Sulfatase; Region: Sulfatase; pfam00884 243090013075 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090013076 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090013077 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090013078 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090013079 multifunctional aminopeptidase A; Provisional; Region: PRK00913 243090013080 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 243090013081 interface (dimer of trimers) [polypeptide binding]; other site 243090013082 Substrate-binding/catalytic site; other site 243090013083 Zn-binding sites [ion binding]; other site 243090013084 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243090013085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090013086 active site 243090013087 phosphorylation site [posttranslational modification] 243090013088 intermolecular recognition site; other site 243090013089 Sec20; Region: Sec20; pfam03908 243090013090 dimerization interface [polypeptide binding]; other site 243090013091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090013092 Walker A motif; other site 243090013093 ATP binding site [chemical binding]; other site 243090013094 Walker B motif; other site 243090013095 arginine finger; other site 243090013096 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243090013097 SLA1 homology domain 1, SHD1; Region: SHD1; pfam03983 243090013098 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 243090013099 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243090013100 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243090013101 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 243090013102 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243090013103 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243090013104 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 243090013105 IMP binding site; other site 243090013106 dimer interface [polypeptide binding]; other site 243090013107 partial ornithine binding site; other site 243090013108 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 243090013109 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 243090013110 active site 243090013111 catalytic site [active] 243090013112 substrate binding site [chemical binding]; other site 243090013113 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 243090013114 Dimer interface [polypeptide binding]; other site 243090013115 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090013116 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090013117 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090013118 Coiled-coil domain of unknown function; Region: CCDC92; pfam14916 243090013119 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090013120 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 243090013121 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 243090013122 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 243090013123 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 243090013124 active site 243090013125 dimer interface [polypeptide binding]; other site 243090013126 motif 1; other site 243090013127 motif 2; other site 243090013128 motif 3; other site 243090013129 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 243090013130 anticodon binding site; other site 243090013131 hypothetical protein; Provisional; Region: PRK08201 243090013132 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 243090013133 metal binding site [ion binding]; metal-binding site 243090013134 putative dimer interface [polypeptide binding]; other site 243090013135 cosmid pircos-a3b08/ cosmid pircos-c1b07 joining point 243090013136 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 243090013137 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 243090013138 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 243090013139 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090013140 FeS/SAM binding site; other site 243090013141 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 243090013142 homodimer interface [polypeptide binding]; other site 243090013143 chemical substrate binding site [chemical binding]; other site 243090013144 oligomer interface [polypeptide binding]; other site 243090013145 metal binding site [ion binding]; metal-binding site 243090013146 Elongation factor Tu; Provisional; Region: PLN03127 243090013147 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 243090013148 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 243090013149 ATP binding site [chemical binding]; other site 243090013150 substrate interface [chemical binding]; other site 243090013151 C-terminal peptidase (prc); Region: prc; TIGR00225 243090013152 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 243090013153 protein binding site [polypeptide binding]; other site 243090013154 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 243090013155 Catalytic dyad [active] 243090013156 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 243090013157 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 243090013158 putative active site pocket [active] 243090013159 dimerization interface [polypeptide binding]; other site 243090013160 putative catalytic residue [active] 243090013161 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090013162 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090013163 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090013164 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090013165 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243090013166 catalytic residues [active] 243090013167 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 243090013168 putative active site [active] 243090013169 putative CoA binding site [chemical binding]; other site 243090013170 nudix motif; other site 243090013171 metal binding site [ion binding]; metal-binding site 243090013172 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090013173 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090013174 Rod binding protein; Region: Rod-binding; pfam10135 243090013175 Flagellar P-ring protein; Region: FlgI; pfam02119 243090013176 Flagellar L-ring protein; Region: FlgH; cl19182 243090013177 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 243090013178 flagellar basal-body rod protein FlgG, Gram-negative bacteria; Region: flgG_G_neg; TIGR02488 243090013179 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 243090013180 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 243090013181 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 243090013182 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 243090013183 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 243090013184 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 243090013185 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243090013186 metal binding site [ion binding]; metal-binding site 243090013187 active site 243090013188 I-site; other site 243090013189 cosmid pircos-c1b07/ cosmid pircos-c4h04 joining point 243090013190 BON domain; Region: BON; pfam04972 243090013191 Asparagine synthase; Region: Asn_synthase; pfam00733 243090013192 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 243090013193 ATP binding site [chemical binding]; other site 243090013194 active site 243090013195 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 243090013196 substrate binding site [chemical binding]; other site 243090013197 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 243090013198 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 243090013199 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 243090013200 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 243090013201 active site 243090013202 catalytic residues [active] 243090013203 DNA binding site [nucleotide binding] 243090013204 Int/Topo IB signature motif; other site 243090013205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243090013206 non-specific DNA binding site [nucleotide binding]; other site 243090013207 salt bridge; other site 243090013208 sequence-specific DNA binding site [nucleotide binding]; other site 243090013209 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 243090013210 nudix motif; other site 243090013211 Helix-turn-helix domain; Region: HTH_36; pfam13730 243090013212 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 243090013213 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090013214 Walker A motif; other site 243090013215 ATP binding site [chemical binding]; other site 243090013216 Walker B motif; other site 243090013217 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cd00525 243090013218 nucleotide binding site [chemical binding]; other site 243090013219 DoxX-like family; Region: DoxX_2; pfam13564 243090013220 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 243090013221 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 243090013222 Bacterial PH domain; Region: bPH_2; pfam03703 243090013223 BON domain; Region: BON; pfam04972 243090013224 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 243090013225 BON domain; Region: BON; pfam04972 243090013226 BON domain; Region: BON; pfam04972 243090013227 BON domain; Region: BON; pfam04972 243090013228 BON domain; Region: BON; pfam04972 243090013229 BON domain; Region: BON; pfam04972 243090013230 DDE superfamily endonuclease; Region: DDE_5; pfam13546 243090013231 Chondroitinase B; Region: Chondroitinas_B; pfam14592 243090013232 Right handed beta helix region; Region: Beta_helix; pfam13229 243090013233 TIGR03643 family protein; Region: TIGR03643 243090013234 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090013235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090013236 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090013237 DNA binding residues [nucleotide binding] 243090013238 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 243090013239 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 243090013240 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 243090013241 active site 243090013242 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 243090013243 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 243090013244 heme-binding site [chemical binding]; other site 243090013245 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 243090013246 FAD binding pocket [chemical binding]; other site 243090013247 FAD binding motif [chemical binding]; other site 243090013248 phosphate binding motif [ion binding]; other site 243090013249 beta-alpha-beta structure motif; other site 243090013250 NAD binding pocket [chemical binding]; other site 243090013251 Heme binding pocket [chemical binding]; other site 243090013252 Cupin domain; Region: Cupin_2; cl17218 243090013253 QPP; Region: QPP; pfam07640 243090013254 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 243090013255 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 243090013256 dimerization interface [polypeptide binding]; other site 243090013257 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 243090013258 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243090013259 B3/4 domain; Region: B3_4; cl19243 243090013260 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243090013261 cosmid pircos-c4h04/ cosmid pircos-c4f06 joining point 243090013262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090013263 S-adenosylmethionine binding site [chemical binding]; other site 243090013264 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 243090013265 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 243090013266 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 243090013267 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 243090013268 ligand binding site [chemical binding]; other site 243090013269 homodimer interface [polypeptide binding]; other site 243090013270 NAD(P) binding site [chemical binding]; other site 243090013271 trimer interface B [polypeptide binding]; other site 243090013272 trimer interface A [polypeptide binding]; other site 243090013273 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 243090013274 classical (c) SDRs; Region: SDR_c; cd05233 243090013275 NAD(P) binding site [chemical binding]; other site 243090013276 active site 243090013277 PRC-barrel domain; Region: PRC; pfam05239 243090013278 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090013279 active site 243090013280 PQQ-like domain; Region: PQQ_2; pfam13360 243090013281 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 243090013282 PQQ-like domain; Region: PQQ_2; pfam13360 243090013283 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 243090013284 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090013285 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090013286 active site 243090013287 ATP binding site [chemical binding]; other site 243090013288 substrate binding site [chemical binding]; other site 243090013289 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090013290 substrate binding site [chemical binding]; other site 243090013291 activation loop (A-loop); other site 243090013292 activation loop (A-loop); other site 243090013293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090013294 binding surface 243090013295 TPR motif; other site 243090013296 ECF sigma factor; Region: Sigma70_ECF; pfam07638 243090013297 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090013298 maltose O-acetyltransferase; Provisional; Region: PRK10092 243090013299 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 243090013300 active site 243090013301 substrate binding site [chemical binding]; other site 243090013302 trimer interface [polypeptide binding]; other site 243090013303 CoA binding site [chemical binding]; other site 243090013304 cosmid pircos-c4f06/ cosmid gap joining point 243090013305 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 243090013306 putative active site [active] 243090013307 putative metal binding site [ion binding]; other site 243090013308 PRC-barrel domain; Region: PRC; pfam05239 243090013309 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090013310 Sulfatase; Region: Sulfatase; pfam00884 243090013311 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090013312 GAF domain; Region: GAF; pfam01590 243090013313 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243090013314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090013315 putative active site [active] 243090013316 heme pocket [chemical binding]; other site 243090013317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090013318 dimer interface [polypeptide binding]; other site 243090013319 phosphorylation site [posttranslational modification] 243090013320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090013321 ATP binding site [chemical binding]; other site 243090013322 Mg2+ binding site [ion binding]; other site 243090013323 G-X-G motif; other site 243090013324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090013325 active site 243090013326 phosphorylation site [posttranslational modification] 243090013327 intermolecular recognition site; other site 243090013328 dimerization interface [polypeptide binding]; other site 243090013329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243090013330 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243090013331 putative substrate translocation pore; other site 243090013332 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 243090013333 Peptidase family M50; Region: Peptidase_M50; pfam02163 243090013334 active site 243090013335 putative substrate binding region [chemical binding]; other site 243090013336 cosmid gap/ cosmid pircos-c3e06 joining point 243090013337 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 243090013338 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243090013339 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 243090013340 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 243090013341 sucrose phosphorylase; Provisional; Region: PRK13840 243090013342 active site 243090013343 homodimer interface [polypeptide binding]; other site 243090013344 catalytic site [active] 243090013345 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 243090013346 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090013347 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090013348 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 243090013349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243090013350 motif II; other site 243090013351 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 243090013352 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 243090013353 active site 243090013354 catalytic triad [active] 243090013355 oxyanion hole [active] 243090013356 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243090013357 Cytochrome c; Region: Cytochrom_C; cl11414 243090013358 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 243090013359 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 243090013360 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 243090013361 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 243090013362 substrate binding [chemical binding]; other site 243090013363 active site 243090013364 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 243090013365 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 243090013366 adenosine kinase; Provisional; Region: PTZ00247 243090013367 substrate binding site [chemical binding]; other site 243090013368 ATP binding site [chemical binding]; other site 243090013369 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 243090013370 putative catalytic residues [active] 243090013371 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 243090013372 Part of AAA domain; Region: AAA_19; pfam13245 243090013373 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 243090013374 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 243090013375 RNA polymerase sigma factor; Provisional; Region: PRK11924 243090013376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090013377 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243090013378 DNA binding residues [nucleotide binding] 243090013379 putative anti-sigmaE protein; Provisional; Region: PRK13920 243090013380 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 243090013381 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 243090013382 Lumazine binding domain; Region: Lum_binding; pfam00677 243090013383 Lumazine binding domain; Region: Lum_binding; pfam00677 243090013384 enolase; Provisional; Region: eno; PRK00077 243090013385 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 243090013386 dimer interface [polypeptide binding]; other site 243090013387 metal binding site [ion binding]; metal-binding site 243090013388 substrate binding pocket [chemical binding]; other site 243090013389 Trm112p-like protein; Region: Trm112p; pfam03966 243090013390 DDE superfamily endonuclease; Region: DDE_5; pfam13546 243090013391 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090013392 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090013393 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 243090013394 cosmid pircos-c3e06/ cosmid pircos-a2b08 joining point 243090013395 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 243090013396 lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150 243090013397 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 243090013398 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090013399 metal ion-dependent adhesion site (MIDAS); other site 243090013400 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 243090013401 von Willebrand factor type A domain; Region: VWA_2; pfam13519 243090013402 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 243090013403 VanZ like family; Region: VanZ; cl01971 243090013404 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 243090013405 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 243090013406 nucleoside/Zn binding site; other site 243090013407 dimer interface [polypeptide binding]; other site 243090013408 catalytic motif [active] 243090013409 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 243090013410 Leucine-rich repeats; other site 243090013411 Substrate binding site [chemical binding]; other site 243090013412 Antagonist of mitotic exit network protein 1; Region: AMN1; cd09293 243090013413 DinB superfamily; Region: DinB_2; pfam12867 243090013414 Ion transport protein; Region: Ion_trans; pfam00520 243090013415 Ion channel; Region: Ion_trans_2; pfam07885 243090013416 Double zinc ribbon; Region: DZR; pfam12773 243090013417 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243090013418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090013419 TPR motif; other site 243090013420 binding surface 243090013421 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090013422 Sulfatase; Region: Sulfatase; cl19157 243090013423 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090013424 Sulfatase; Region: Sulfatase; pfam00884 243090013425 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090013426 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 243090013427 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 243090013428 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243090013429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090013430 binding surface 243090013431 TPR motif; other site 243090013432 Tetratricopeptide repeat; Region: TPR_17; pfam13431 243090013433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090013434 binding surface 243090013435 TPR motif; other site 243090013436 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 243090013437 ABC-ATPase subunit interface; other site 243090013438 dimer interface [polypeptide binding]; other site 243090013439 putative PBP binding regions; other site 243090013440 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 243090013441 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 243090013442 ABC-ATPase subunit interface; other site 243090013443 dimer interface [polypeptide binding]; other site 243090013444 putative PBP binding regions; other site 243090013445 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 243090013446 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 243090013447 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 243090013448 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 243090013449 Protein of unknown function (DUF1586); Region: DUF1586; pfam07625 243090013450 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 243090013451 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 243090013452 metal binding site [ion binding]; metal-binding site 243090013453 intersubunit interface [polypeptide binding]; other site 243090013454 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_22; cd04681 243090013455 nudix motif; other site 243090013456 thymidylate kinase; Validated; Region: tmk; PRK00698 243090013457 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 243090013458 TMP-binding site; other site 243090013459 ATP-binding site [chemical binding]; other site 243090013460 Antagonist of mitotic exit network protein 1; Region: AMN1; cd09293 243090013461 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 243090013462 Mannitol repressor; Region: MtlR; cl11450 243090013463 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 243090013464 cosmid pircos-a2b08/ cosmid pircos-b1b08 joining point 243090013465 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; cl09440 243090013466 Protein of unknown function (DUF3720); Region: DUF3720; pfam12517 243090013467 Neuromodulin; Region: Neuromodulin; pfam06614 243090013468 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 243090013469 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 243090013470 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 243090013471 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 243090013472 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 243090013473 dimerization interface [polypeptide binding]; other site 243090013474 active site 243090013475 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 243090013476 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243090013477 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090013478 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243090013479 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090013480 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090013481 active site 243090013482 ATP binding site [chemical binding]; other site 243090013483 substrate binding site [chemical binding]; other site 243090013484 activation loop (A-loop); other site 243090013485 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090013486 Ehrlichia tandem repeat (Ehrlichia_rpt); Region: Ehrlichia_rpt; pfam09528 243090013487 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 243090013488 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 243090013489 hypothetical protein; Provisional; Region: PRK12705 243090013490 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 243090013491 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 243090013492 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 243090013493 Walker A motif/ATP binding site; other site 243090013494 Walker B motif; other site 243090013495 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 243090013496 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 243090013497 Flagellar assembly protein FliH; Region: FliH; cl19405 243090013498 MgtE intracellular N domain; Region: MgtE_N; cl15244 243090013499 FliG middle domain; Region: FliG_M; pfam14841 243090013500 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243090013501 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243090013502 anti sigma factor interaction site; other site 243090013503 regulatory phosphorylation site [posttranslational modification]; other site 243090013504 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 243090013505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090013506 ATP binding site [chemical binding]; other site 243090013507 Mg2+ binding site [ion binding]; other site 243090013508 G-X-G motif; other site 243090013509 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 243090013510 autotransport protein MisL; Provisional; Region: PRK15313 243090013511 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 243090013512 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 243090013513 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 243090013514 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 243090013515 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 243090013516 cosmid pircos-b1b08/ cosmid pircos-c3h12 joining point 243090013517 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 243090013518 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 243090013519 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243090013520 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090013521 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090013522 HlyD family secretion protein; Region: HlyD_3; pfam13437 243090013523 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 243090013524 active site 243090013525 putative substrate binding region [chemical binding]; other site 243090013526 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243090013527 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243090013528 RF-1 domain; Region: RF-1; cl17422 243090013529 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 243090013530 Fibronectin type III domain; Region: fn3; pfam00041 243090013531 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243090013532 active site 243090013533 metal binding site [ion binding]; metal-binding site 243090013534 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243090013535 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090013536 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243090013537 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243090013538 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243090013539 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243090013540 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243090013541 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243090013542 catalytic residues [active] 243090013543 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 243090013544 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 243090013545 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 243090013546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243090013547 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 243090013548 Di-iron ligands [ion binding]; other site 243090013549 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 243090013550 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 243090013551 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 243090013552 active site 243090013553 dimer interface [polypeptide binding]; other site 243090013554 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090013555 Trp docking motif [polypeptide binding]; other site 243090013556 PQQ-like domain; Region: PQQ_2; pfam13360 243090013557 active site 243090013558 cosmid pircos-c3h12/ cosmid pircos-a2f08 joining point 243090013559 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243090013560 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243090013561 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090013562 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090013563 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090013564 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090013565 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243090013566 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243090013567 phosphopeptide binding site; other site 243090013568 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243090013569 metal binding site [ion binding]; metal-binding site 243090013570 active site 243090013571 I-site; other site 243090013572 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090013573 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090013574 active site 243090013575 ATP binding site [chemical binding]; other site 243090013576 substrate binding site [chemical binding]; other site 243090013577 activation loop (A-loop); other site 243090013578 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 243090013579 elongation factor P; Provisional; Region: PRK04542 243090013580 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 243090013581 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 243090013582 RNA binding site [nucleotide binding]; other site 243090013583 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 243090013584 RNA binding site [nucleotide binding]; other site 243090013585 Domain of unknown function (DUF4437); Region: DUF4437; pfam14499 243090013586 Domain of unknown function (DUF4437); Region: DUF4437; pfam14499 243090013587 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090013588 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 243090013589 putative ADP-binding pocket [chemical binding]; other site 243090013590 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 243090013591 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 243090013592 cosmid pircos-a2f08/ cosmid pircos-b2g11 joining point 243090013593 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243090013594 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 243090013595 Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_1; cd10940 243090013596 putative active site [active] 243090013597 putative catalytic site [active] 243090013598 putative Zn binding site [ion binding]; other site 243090013599 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 243090013600 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243090013601 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243090013602 Bacterial sugar transferase; Region: Bac_transf; pfam02397 243090013603 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 243090013604 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243090013605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243090013606 S-adenosylmethionine binding site [chemical binding]; other site 243090013607 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 243090013608 dimerization interface [polypeptide binding]; other site 243090013609 active site 243090013610 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 243090013611 folate binding site [chemical binding]; other site 243090013612 NADP+ binding site [chemical binding]; other site 243090013613 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 243090013614 30S ribosomal protein S11; Validated; Region: PRK05309 243090013615 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 243090013616 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 243090013617 alphaNTD homodimer interface [polypeptide binding]; other site 243090013618 alphaNTD - beta interaction site [polypeptide binding]; other site 243090013619 alphaNTD - beta' interaction site [polypeptide binding]; other site 243090013620 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 243090013621 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 243090013622 BNR repeat-like domain; Region: BNR_2; pfam13088 243090013623 Amidohydrolase; Region: Amidohydro_2; pfam04909 243090013624 Cupin-like domain; Region: Cupin_8; cl19305 243090013625 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 243090013626 ATP-grasp in the biosynthetic pathway with Ter operon; Region: ATPgrasp_Ter; pfam15632 243090013627 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243090013628 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 243090013629 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 243090013630 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 243090013631 GH3 auxin-responsive promoter; Region: GH3; pfam03321 243090013632 indole-3-acetic acid-amido synthetase; Region: PLN02620 243090013633 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 243090013634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090013635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090013636 dimer interface [polypeptide binding]; other site 243090013637 phosphorylation site [posttranslational modification] 243090013638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090013639 ATP binding site [chemical binding]; other site 243090013640 Mg2+ binding site [ion binding]; other site 243090013641 G-X-G motif; other site 243090013642 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 243090013643 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 243090013644 glutaminase active site [active] 243090013645 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 243090013646 dimer interface [polypeptide binding]; other site 243090013647 active site 243090013648 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 243090013649 dimer interface [polypeptide binding]; other site 243090013650 active site 243090013651 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 243090013652 substrate binding site [chemical binding]; other site 243090013653 ligand binding site [chemical binding]; other site 243090013654 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 243090013655 substrate binding site [chemical binding]; other site 243090013656 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 243090013657 active site 243090013658 dimer interface [polypeptide binding]; other site 243090013659 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243090013660 heme-binding residues [chemical binding]; other site 243090013661 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 243090013662 The MopB_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding (MopB) proteins. This CD is of the PHLH region homologous to the catalytic molybdopterin-binding subunit of MopB homologs; Region: MopB_PHLH; cd02764 243090013663 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 243090013664 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 243090013665 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243090013666 Polysulphide reductase, NrfD; Region: NrfD; cl19193 243090013667 cosmid pircos-b2g11/ cosmid pircos-a4b04 joining point 243090013668 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 243090013669 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 243090013670 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 243090013671 Cu(I) binding site [ion binding]; other site 243090013672 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 243090013673 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 243090013674 Cupredoxin superfamily; Region: Cupredoxin; cl19115 243090013675 Cytochrome c; Region: Cytochrom_C; cl11414 243090013676 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 243090013677 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 243090013678 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 243090013679 Subunit I/III interface [polypeptide binding]; other site 243090013680 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 243090013681 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 243090013682 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 243090013683 Ligand binding site; other site 243090013684 oligomer interface; other site 243090013685 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 243090013686 Protein kinase domain; Region: Pkinase; pfam00069 243090013687 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090013688 active site 243090013689 ATP binding site [chemical binding]; other site 243090013690 substrate binding site [chemical binding]; other site 243090013691 activation loop (A-loop); other site 243090013692 Planctomycete extracellular; Region: Planc_extracel; pfam07595 243090013693 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 243090013694 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090013695 conserved repeat domain; Region: B_ant_repeat; TIGR01451 243090013696 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_1; cd13964 243090013697 putative active site [active] 243090013698 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 243090013699 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 243090013700 ligand binding surface [chemical binding]; other site 243090013701 Bacterial Ig-like domain; Region: Big_5; pfam13205 243090013702 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 243090013703 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 243090013704 Dockerin type I repeat; Region: Dockerin_1; pfam00404 243090013705 DNA methylase; Region: N6_N4_Mtase; pfam01555 243090013706 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 243090013707 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243090013708 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090013709 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090013710 DNA binding residues [nucleotide binding] 243090013711 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090013712 cosmid pircos-a4b04/ cosmid pircos-b1b03 joining point 243090013713 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090013714 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090013715 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243090013716 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 243090013717 Rhoptry-associated protein 1 (RAP-1); Region: RAP1; pfam07218 243090013718 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 243090013719 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 243090013720 dimerization interface [polypeptide binding]; other site 243090013721 putative ATP binding site [chemical binding]; other site 243090013722 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 243090013723 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 243090013724 putative DNA binding site [nucleotide binding]; other site 243090013725 catalytic residue [active] 243090013726 putative H2TH interface [polypeptide binding]; other site 243090013727 putative catalytic residues [active] 243090013728 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 243090013729 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 243090013730 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243090013731 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243090013732 protein binding site [polypeptide binding]; other site 243090013733 2-isopropylmalate synthase; Validated; Region: PRK00915 243090013734 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 243090013735 active site 243090013736 catalytic residues [active] 243090013737 metal binding site [ion binding]; metal-binding site 243090013738 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 243090013739 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 243090013740 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 243090013741 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 243090013742 active site 243090013743 dimer interface [polypeptide binding]; other site 243090013744 effector binding site; other site 243090013745 TSCPD domain; Region: TSCPD; pfam12637 243090013746 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243090013747 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243090013748 phosphopeptide binding site; other site 243090013749 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243090013750 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 243090013751 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243090013752 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 243090013753 Walker A motif; other site 243090013754 ATP binding site [chemical binding]; other site 243090013755 Walker B motif; other site 243090013756 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 243090013757 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 243090013758 Walker A motif; other site 243090013759 ATP binding site [chemical binding]; other site 243090013760 Walker B motif; other site 243090013761 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 243090013762 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243090013763 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 243090013764 Walker A motif; other site 243090013765 ATP binding site [chemical binding]; other site 243090013766 Walker B motif; other site 243090013767 23S rRNA-intervening sequence protein; Region: 23S_rRNA_IVP; pfam05635 243090013768 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 243090013769 YhzD-like protein; Region: YhzD; pfam14120 243090013770 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243090013771 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243090013772 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090013773 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090013774 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090013775 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090013776 cosmid pircos-b1b03/ cosmid pircos-c3d08 joining point 243090013777 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 243090013778 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090013779 DNA polymerase I; Provisional; Region: PRK05755 243090013780 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 243090013781 active site 243090013782 metal binding site 1 [ion binding]; metal-binding site 243090013783 putative 5' ssDNA interaction site; other site 243090013784 metal binding site 3; metal-binding site 243090013785 metal binding site 2 [ion binding]; metal-binding site 243090013786 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 243090013787 putative DNA binding site [nucleotide binding]; other site 243090013788 putative metal binding site [ion binding]; other site 243090013789 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 243090013790 active site 243090013791 catalytic site [active] 243090013792 substrate binding site [chemical binding]; other site 243090013793 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 243090013794 active site 243090013795 DNA binding site [nucleotide binding] 243090013796 catalytic site [active] 243090013797 phosphodiesterase; Provisional; Region: PRK12704 243090013798 Mucin-like glycoprotein; Region: Mucin; pfam01456 243090013799 TraB family; Region: TraB; cl12050 243090013800 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 243090013801 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 243090013802 dimer interface [polypeptide binding]; other site 243090013803 active site 243090013804 CoA binding pocket [chemical binding]; other site 243090013805 Peptidase C26; Region: Peptidase_C26; pfam07722 243090013806 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 243090013807 catalytic triad [active] 243090013808 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 243090013809 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 243090013810 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 243090013811 signal recognition particle protein; Provisional; Region: PRK10867 243090013812 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 243090013813 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 243090013814 P loop; other site 243090013815 GTP binding site [chemical binding]; other site 243090013816 Signal peptide binding domain; Region: SRP_SPB; pfam02978 243090013817 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 243090013818 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243090013819 Ligand binding site; other site 243090013820 Putative Catalytic site; other site 243090013821 DXD motif; other site 243090013822 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 243090013823 mRNA/rRNA interface [nucleotide binding]; other site 243090013824 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 243090013825 23S rRNA interface [nucleotide binding]; other site 243090013826 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 243090013827 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 243090013828 peripheral dimer interface [polypeptide binding]; other site 243090013829 core dimer interface [polypeptide binding]; other site 243090013830 L10 interface [polypeptide binding]; other site 243090013831 L11 interface [polypeptide binding]; other site 243090013832 putative EF-Tu interaction site [polypeptide binding]; other site 243090013833 putative EF-G interaction site [polypeptide binding]; other site 243090013834 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090013835 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090013836 Protein of unknown function (DUF1589); Region: DUF1589; pfam07628 243090013837 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 243090013838 cosmid pircos-c3d08/ cosmid pircos-a1d06 joining point 243090013839 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 243090013840 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 243090013841 putative active site [active] 243090013842 substrate binding site [chemical binding]; other site 243090013843 putative cosubstrate binding site; other site 243090013844 catalytic site [active] 243090013845 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 243090013846 substrate binding site [chemical binding]; other site 243090013847 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 243090013848 active site 243090013849 catalytic residues [active] 243090013850 metal binding site [ion binding]; metal-binding site 243090013851 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 243090013852 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243090013853 Walker A/P-loop; other site 243090013854 ATP binding site [chemical binding]; other site 243090013855 Q-loop/lid; other site 243090013856 ABC transporter signature motif; other site 243090013857 Walker B; other site 243090013858 D-loop; other site 243090013859 H-loop/switch region; other site 243090013860 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243090013861 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 243090013862 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243090013863 Walker A/P-loop; other site 243090013864 ATP binding site [chemical binding]; other site 243090013865 Q-loop/lid; other site 243090013866 ABC transporter signature motif; other site 243090013867 Walker B; other site 243090013868 D-loop; other site 243090013869 H-loop/switch region; other site 243090013870 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243090013871 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 243090013872 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 243090013873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243090013874 dimer interface [polypeptide binding]; other site 243090013875 conserved gate region; other site 243090013876 putative PBP binding loops; other site 243090013877 ABC-ATPase subunit interface; other site 243090013878 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 243090013879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243090013880 dimer interface [polypeptide binding]; other site 243090013881 conserved gate region; other site 243090013882 putative PBP binding loops; other site 243090013883 ABC-ATPase subunit interface; other site 243090013884 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 243090013885 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 243090013886 peptide binding site [polypeptide binding]; other site 243090013887 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 243090013888 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243090013889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243090013890 homodimer interface [polypeptide binding]; other site 243090013891 catalytic residue [active] 243090013892 Protein of unknown function (DUF962); Region: DUF962; cl01879 243090013893 Glucose-regulated metallo-peptidase M90; Region: Peptidase_M90; pfam06167 243090013894 SEC-C motif; Region: SEC-C; pfam02810 243090013895 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090013896 Protein of unknown function (DUF1589); Region: DUF1589; pfam07628 243090013897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090013898 active site 243090013899 phosphorylation site [posttranslational modification] 243090013900 intermolecular recognition site; other site 243090013901 dimerization interface [polypeptide binding]; other site 243090013902 NVEALA protein; Region: NVEALA; pfam14055 243090013903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090013904 TPR motif; other site 243090013905 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 243090013906 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243090013907 RNA binding surface [nucleotide binding]; other site 243090013908 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243090013909 active site 243090013910 Integral membrane protein TerC family; Region: TerC; pfam03741 243090013911 Calpain inhibitor; Region: Calpain_inhib; pfam00748 243090013912 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 243090013913 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243090013914 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243090013915 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090013916 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243090013917 active site 243090013918 ATP binding site [chemical binding]; other site 243090013919 substrate binding site [chemical binding]; other site 243090013920 activation loop (A-loop); other site 243090013921 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 243090013922 acetolactate synthase; Region: PLN02470 243090013923 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243090013924 PYR/PP interface [polypeptide binding]; other site 243090013925 dimer interface [polypeptide binding]; other site 243090013926 TPP binding site [chemical binding]; other site 243090013927 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243090013928 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 243090013929 TPP-binding site [chemical binding]; other site 243090013930 dimer interface [polypeptide binding]; other site 243090013931 CrcB-like protein; Region: CRCB; pfam02537 243090013932 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 243090013933 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 243090013934 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 243090013935 TPP-binding site [chemical binding]; other site 243090013936 dimer interface [polypeptide binding]; other site 243090013937 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243090013938 PYR/PP interface [polypeptide binding]; other site 243090013939 dimer interface [polypeptide binding]; other site 243090013940 TPP binding site [chemical binding]; other site 243090013941 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243090013942 cosmid pircos-a1d06/ cosmid pircos-b2e12 joining point 243090013943 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 243090013944 GDP-binding site [chemical binding]; other site 243090013945 ACT binding site; other site 243090013946 IMP binding site; other site 243090013947 Protein of unknown function (DUF1560); Region: DUF1560; pfam07597 243090013948 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 243090013949 Beta-lactamase; Region: Beta-lactamase; pfam00144 243090013950 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 243090013951 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243090013952 catalytic residue [active] 243090013953 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 243090013954 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090013955 metal ion-dependent adhesion site (MIDAS); other site 243090013956 Transposase; Region: HTH_Tnp_1; cl17663 243090013957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 243090013958 putative transposase OrfB; Reviewed; Region: PHA02517 243090013959 HTH-like domain; Region: HTH_21; pfam13276 243090013960 Integrase core domain; Region: rve; pfam00665 243090013961 Integrase core domain; Region: rve_3; pfam13683 243090013962 PQQ-like domain; Region: PQQ_2; pfam13360 243090013963 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090013964 Trp docking motif [polypeptide binding]; other site 243090013965 hypothetical protein; Provisional; Region: PRK09256 243090013966 UvrB/uvrC motif; Region: UVR; pfam02151 243090013967 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 243090013968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090013969 ATP binding site [chemical binding]; other site 243090013970 Mg2+ binding site [ion binding]; other site 243090013971 G-X-G motif; other site 243090013972 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 243090013973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090013974 active site 243090013975 phosphorylation site [posttranslational modification] 243090013976 intermolecular recognition site; other site 243090013977 dimerization interface [polypeptide binding]; other site 243090013978 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243090013979 DEC-1 protein, N-terminal region; Region: DEC-1_N; pfam04625 243090013980 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 243090013981 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243090013982 FeS/SAM binding site; other site 243090013983 BON domain; Region: BON; pfam04972 243090013984 ATP phosphoribosyltransferase; Region: HisG; cl15266 243090013985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090013986 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243090013987 Walker A motif; other site 243090013988 ATP binding site [chemical binding]; other site 243090013989 Walker B motif; other site 243090013990 PRMT5 arginine-N-methyltransferase; Region: PRMT5; cl17640 243090013991 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 243090013992 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243090013993 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243090013994 ligand binding site [chemical binding]; other site 243090013995 flexible hinge region; other site 243090013996 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 243090013997 ligand binding site [chemical binding]; other site 243090013998 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 243090013999 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 243090014000 M28 Zn-Peptidases; Region: M28_like_6; cd08656 243090014001 metal binding site [ion binding]; metal-binding site 243090014002 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243090014003 Sel1-like repeats; Region: SEL1; smart00671 243090014004 Sel1-like repeats; Region: SEL1; smart00671 243090014005 Sel1-like repeats; Region: SEL1; smart00671 243090014006 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243090014007 Sel1-like repeats; Region: SEL1; smart00671 243090014008 Sel1-like repeats; Region: SEL1; smart00671 243090014009 Sel1-like repeats; Region: SEL1; smart00671 243090014010 Sel1-like repeats; Region: SEL1; smart00671 243090014011 Sel1-like repeats; Region: SEL1; smart00671 243090014012 Sel1-like repeats; Region: SEL1; smart00671 243090014013 Sel1-like repeats; Region: SEL1; smart00671 243090014014 Sel1-like repeats; Region: SEL1; smart00671 243090014015 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 243090014016 Leucine rich repeat; Region: LRR_8; pfam13855 243090014017 Substrate binding site [chemical binding]; other site 243090014018 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 243090014019 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 243090014020 Squalene epoxidase; Region: SE; cl17314 243090014021 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 243090014022 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243090014023 cosmid pircos-b2e12/ cosmid pircos-d3c02 joining point 243090014024 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243090014025 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090014026 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090014027 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090014028 Predicted permease; Region: DUF318; cl17795 243090014029 MoxR-like ATPases [General function prediction only]; Region: COG0714 243090014030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090014031 Walker A motif; other site 243090014032 ATP binding site [chemical binding]; other site 243090014033 Walker B motif; other site 243090014034 arginine finger; other site 243090014035 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 243090014036 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243090014037 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243090014038 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243090014039 Protein of unknown function DUF58; Region: DUF58; pfam01882 243090014040 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 243090014041 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243090014042 Trp docking motif [polypeptide binding]; other site 243090014043 active site 243090014044 PQQ-like domain; Region: PQQ_2; pfam13360 243090014045 Class III signal peptide; Region: Class_IIIsignal; pfam04021 243090014046 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 243090014047 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 243090014048 TadE-like protein; Region: TadE; pfam07811 243090014049 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 243090014050 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 243090014051 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 243090014052 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243090014053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 243090014054 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 243090014055 AAA domain; Region: AAA_31; pfam13614 243090014056 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 243090014057 ATP binding site [chemical binding]; other site 243090014058 Walker A motif; other site 243090014059 hexamer interface [polypeptide binding]; other site 243090014060 Walker B motif; other site 243090014061 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 243090014062 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243090014063 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 243090014064 High-affinity nickel-transport protein; Region: NicO; cl00964 243090014065 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 243090014066 putative active site [active] 243090014067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243090014068 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 243090014069 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 243090014070 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 243090014071 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 243090014072 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 243090014073 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243090014074 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 243090014075 MerC mercury resistance protein; Region: MerC; pfam03203 243090014076 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 243090014077 metal binding site 2 [ion binding]; metal-binding site 243090014078 putative DNA binding helix; other site 243090014079 metal binding site 1 [ion binding]; metal-binding site 243090014080 dimer interface [polypeptide binding]; other site 243090014081 structural Zn2+ binding site [ion binding]; other site 243090014082 cosmid pircos-d3c02/ cosmid pircos-c1f02 joining point 243090014083 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 243090014084 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 243090014085 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243090014086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090014087 binding surface 243090014088 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243090014089 TPR motif; other site 243090014090 TPR repeat; Region: TPR_11; pfam13414 243090014091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090014092 binding surface 243090014093 TPR motif; other site 243090014094 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 243090014095 active site 243090014096 metal binding site [ion binding]; metal-binding site 243090014097 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 243090014098 nudix motif; other site 243090014099 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243090014100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243090014101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090014102 putative active site [active] 243090014103 heme pocket [chemical binding]; other site 243090014104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090014105 dimer interface [polypeptide binding]; other site 243090014106 phosphorylation site [posttranslational modification] 243090014107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090014108 ATP binding site [chemical binding]; other site 243090014109 Mg2+ binding site [ion binding]; other site 243090014110 G-X-G motif; other site 243090014111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090014112 active site 243090014113 phosphorylation site [posttranslational modification] 243090014114 intermolecular recognition site; other site 243090014115 dimerization interface [polypeptide binding]; other site 243090014116 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 243090014117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090014118 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 243090014119 active site 243090014120 phosphorylation site [posttranslational modification] 243090014121 intermolecular recognition site; other site 243090014122 dimerization interface [polypeptide binding]; other site 243090014123 ANTAR domain; Region: ANTAR; pfam03861 243090014124 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090014125 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090014126 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090014127 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090014128 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090014129 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090014130 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243090014131 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243090014132 QPP; Region: QPP; pfam07640 243090014133 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 243090014134 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 243090014135 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 243090014136 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 243090014137 putative dimerization interface [polypeptide binding]; other site 243090014138 putative ligand binding site [chemical binding]; other site 243090014139 Transcriptional regulators [Transcription]; Region: PurR; COG1609 243090014140 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090014141 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243090014142 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090014143 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 243090014144 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 243090014145 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 243090014146 Planctomycete PGAMP; Region: PGAMP; pfam07644 243090014147 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 243090014148 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 243090014149 active site 243090014150 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090014151 Sulfatase; Region: Sulfatase; pfam00884 243090014152 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090014153 arylsulfatase; Provisional; Region: PRK13759 243090014154 Sulfatase; Region: Sulfatase; pfam00884 243090014155 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090014156 Sulfatase; Region: Sulfatase; pfam00884 243090014157 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 243090014158 Domain of unknown function (DUF303); Region: DUF303; pfam03629 243090014159 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 243090014160 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090014161 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243090014162 Sulfatase; Region: Sulfatase; pfam00884 243090014163 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 243090014164 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 243090014165 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243090014166 arylsulfatase; Provisional; Region: PRK13759 243090014167 Sulfatase; Region: Sulfatase; pfam00884 243090014168 Right handed beta helix region; Region: Beta_helix; pfam13229 243090014169 Transcriptional regulators [Transcription]; Region: PurR; COG1609 243090014170 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 243090014171 putative dimerization interface [polypeptide binding]; other site 243090014172 putative ligand binding site [chemical binding]; other site 243090014173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243090014174 Helix-turn-helix domain; Region: HTH_18; pfam12833 243090014175 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090014176 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090014177 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090014178 putative active site [active] 243090014179 PAS fold; Region: PAS_3; pfam08447 243090014180 heme pocket [chemical binding]; other site 243090014181 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243090014182 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090014183 putative active site [active] 243090014184 heme pocket [chemical binding]; other site 243090014185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090014186 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243090014187 putative active site [active] 243090014188 heme pocket [chemical binding]; other site 243090014189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090014190 putative active site [active] 243090014191 heme pocket [chemical binding]; other site 243090014192 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243090014193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090014194 dimer interface [polypeptide binding]; other site 243090014195 phosphorylation site [posttranslational modification] 243090014196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090014197 ATP binding site [chemical binding]; other site 243090014198 Mg2+ binding site [ion binding]; other site 243090014199 G-X-G motif; other site 243090014200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090014201 active site 243090014202 phosphorylation site [posttranslational modification] 243090014203 intermolecular recognition site; other site 243090014204 dimerization interface [polypeptide binding]; other site 243090014205 cosmid pircos-c1f02/ cosmid pircos-c3d10 joining point 243090014206 circadian clock protein KaiC; Reviewed; Region: PRK09302 243090014207 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090014208 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090014209 Walker A motif; other site 243090014210 Walker A motif; other site 243090014211 ATP binding site [chemical binding]; other site 243090014212 Walker B motif; other site 243090014213 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090014214 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243090014215 Walker A motif; other site 243090014216 ATP binding site [chemical binding]; other site 243090014217 Walker B motif; other site 243090014218 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243090014219 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243090014220 PAS fold; Region: PAS_3; pfam08447 243090014221 putative active site [active] 243090014222 heme pocket [chemical binding]; other site 243090014223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243090014224 dimer interface [polypeptide binding]; other site 243090014225 phosphorylation site [posttranslational modification] 243090014226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243090014227 ATP binding site [chemical binding]; other site 243090014228 Mg2+ binding site [ion binding]; other site 243090014229 G-X-G motif; other site 243090014230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243090014231 active site 243090014232 phosphorylation site [posttranslational modification] 243090014233 intermolecular recognition site; other site 243090014234 dimerization interface [polypeptide binding]; other site 243090014235 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243090014236 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 243090014237 Subtilase family; Region: Peptidase_S8; pfam00082 243090014238 active site 243090014239 catalytic triad [active] 243090014240 DDE superfamily endonuclease; Region: DDE_5; pfam13546 243090014241 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243090014242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243090014243 Walker A motif; other site 243090014244 ATP binding site [chemical binding]; other site 243090014245 Walker B motif; other site 243090014246 arginine finger; other site 243090014247 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243090014248 Predicted membrane protein [Function unknown]; Region: COG2510 243090014249 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243090014250 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 243090014251 Ligand binding site; other site 243090014252 Putative Catalytic site; other site 243090014253 DXD motif; other site 243090014254 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 243090014255 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 243090014256 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 243090014257 Penicillinase repressor; Region: Penicillinase_R; pfam03965 243090014258 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090014259 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 243090014260 active site 243090014261 SOUL heme-binding protein; Region: SOUL; pfam04832 243090014262 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 243090014263 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 243090014264 putative NAD(P) binding site [chemical binding]; other site 243090014265 putative active site [active] 243090014266 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 243090014267 DEAD-like helicases superfamily; Region: DEXDc; smart00487 243090014268 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243090014269 ATP binding site [chemical binding]; other site 243090014270 putative Mg++ binding site [ion binding]; other site 243090014271 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243090014272 nucleotide binding region [chemical binding]; other site 243090014273 ATP-binding site [chemical binding]; other site 243090014274 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873 243090014275 metal binding site [ion binding]; metal-binding site 243090014276 TadE-like protein; Region: TadE; pfam07811 243090014277 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 243090014278 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243090014279 metal ion-dependent adhesion site (MIDAS); other site 243090014280 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 243090014281 TadE-like protein; Region: TadE; pfam07811 243090014282 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 243090014283 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243090014284 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243090014285 DNA binding residues [nucleotide binding] 243090014286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243090014287 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243090014288 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243090014289 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 243090014290 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 243090014291 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 243090014292 NADP binding site [chemical binding]; other site 243090014293 dimer interface [polypeptide binding]; other site 243090014294 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 243090014295 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 243090014296 active site 243090014297 nucleotide binding site [chemical binding]; other site 243090014298 HIGH motif; other site 243090014299 KMSKS motif; other site 243090014300 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 243090014301 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 243090014302 putative dimer interface [polypeptide binding]; other site 243090014303 putative anticodon binding site; other site 243090014304 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 243090014305 homodimer interface [polypeptide binding]; other site 243090014306 motif 1; other site 243090014307 motif 2; other site 243090014308 active site 243090014309 motif 3; other site 243090014310 acetyl-CoA synthetase; Provisional; Region: PRK00174 243090014311 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 243090014312 active site 243090014313 CoA binding site [chemical binding]; other site 243090014314 acyl-activating enzyme (AAE) consensus motif; other site 243090014315 AMP binding site [chemical binding]; other site 243090014316 acetate binding site [chemical binding]; other site 243090014317 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243090014318 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243090014319 active site 243090014320 ATP binding site [chemical binding]; other site 243090014321 substrate binding site [chemical binding]; other site 243090014322 activation loop (A-loop); other site 243090014323 cosmid pircos-c3d10/ cosmid pircos-d3c07 joining point 243090014324 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 243090014325 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243090014326 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl19859 243090014327 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 243090014328 DNA mismatch repair protein MutS; Region: mutS1; TIGR01070 243090014329 type II secretion system protein D; Region: type_II_gspD; TIGR02517 243090014330 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243090014331 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243090014332 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 243090014333 Na binding site [ion binding]; other site 243090014334 aspartate carbamoyltransferase; Region: PLN02527 243090014335 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 243090014336 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 243090014337 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 243090014338 active site 243090014339 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 243090014340 dimer interface [polypeptide binding]; other site 243090014341 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 243090014342 Ligand Binding Site [chemical binding]; other site 243090014343 Molecular Tunnel; other site 243090014344 allantoate amidohydrolase; Reviewed; Region: PRK09290 243090014345 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 243090014346 active site 243090014347 metal binding site [ion binding]; metal-binding site 243090014348 dimer interface [polypeptide binding]; other site 243090014349 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 243090014350 catalytic triad [active] 243090014351 conserved cis-peptide bond; other site 243090014352 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243090014353 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243090014354 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090014355 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090014356 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090014357 cosmid pircos-d3c07/ cosmid gap joining point 243090014358 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 243090014359 catalytic triad [active] 243090014360 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090014361 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243090014362 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090014363 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243090014364 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243090014365 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 243090014366 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 243090014367 TPR repeat; Region: TPR_11; pfam13414 243090014368 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243090014369 binding surface 243090014370 TPR motif; other site 243090014371 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243090014372 cosmid gap/ cosmid pircos-a3a12 joining point