-- dump date   	20140620_032450
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
316056000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
316056000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
316056000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056000004	Walker A motif; other site
316056000005	ATP binding site [chemical binding]; other site
316056000006	Walker B motif; other site
316056000007	arginine finger; other site
316056000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
316056000009	DnaA box-binding interface [nucleotide binding]; other site
316056000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
316056000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
316056000012	putative DNA binding surface [nucleotide binding]; other site
316056000013	dimer interface [polypeptide binding]; other site
316056000014	beta-clamp/clamp loader binding surface; other site
316056000015	beta-clamp/translesion DNA polymerase binding surface; other site
316056000016	recombination protein F; Reviewed; Region: recF; PRK00064
316056000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056000018	Walker A/P-loop; other site
316056000019	ATP binding site [chemical binding]; other site
316056000020	Q-loop/lid; other site
316056000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056000022	ABC transporter signature motif; other site
316056000023	Walker B; other site
316056000024	D-loop; other site
316056000025	H-loop/switch region; other site
316056000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
316056000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056000028	Mg2+ binding site [ion binding]; other site
316056000029	G-X-G motif; other site
316056000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
316056000031	anchoring element; other site
316056000032	dimer interface [polypeptide binding]; other site
316056000033	ATP binding site [chemical binding]; other site
316056000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
316056000035	active site
316056000036	putative metal-binding site [ion binding]; other site
316056000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
316056000038	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
316056000039	putative active site [active]
316056000040	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
316056000041	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316056000042	putative DNA binding site [nucleotide binding]; other site
316056000043	putative Zn2+ binding site [ion binding]; other site
316056000044	AsnC family; Region: AsnC_trans_reg; pfam01037
316056000045	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
316056000046	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
316056000047	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
316056000048	metal-binding site [ion binding]
316056000049	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
316056000050	Soluble P-type ATPase [General function prediction only]; Region: COG4087
316056000051	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
316056000052	FixH; Region: FixH; pfam05751
316056000053	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
316056000054	4Fe-4S binding domain; Region: Fer4_5; pfam12801
316056000055	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
316056000056	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
316056000057	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
316056000058	Cytochrome c; Region: Cytochrom_C; pfam00034
316056000059	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
316056000060	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
316056000061	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
316056000062	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
316056000063	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
316056000064	Low-spin heme binding site [chemical binding]; other site
316056000065	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
316056000066	Putative water exit pathway; other site
316056000067	Binuclear center (active site) [active]
316056000068	Putative proton exit pathway; other site
316056000069	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
316056000070	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
316056000071	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
316056000072	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
316056000073	classical (c) SDR, subgroup  10; Region: SDR_c10; cd05373
316056000074	putative NAD(P) binding site [chemical binding]; other site
316056000075	active site
316056000076	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
316056000077	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
316056000078	putative catalytic residue [active]
316056000079	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
316056000080	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
316056000081	putative C-terminal domain interface [polypeptide binding]; other site
316056000082	putative GSH binding site (G-site) [chemical binding]; other site
316056000083	putative dimer interface [polypeptide binding]; other site
316056000084	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
316056000085	putative N-terminal domain interface [polypeptide binding]; other site
316056000086	putative dimer interface [polypeptide binding]; other site
316056000087	putative substrate binding pocket (H-site) [chemical binding]; other site
316056000088	short chain dehydrogenase; Provisional; Region: PRK08278
316056000089	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
316056000090	NAD(P) binding site [chemical binding]; other site
316056000091	homodimer interface [polypeptide binding]; other site
316056000092	active site
316056000093	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
316056000094	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
316056000095	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
316056000096	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
316056000097	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
316056000098	purine monophosphate binding site [chemical binding]; other site
316056000099	dimer interface [polypeptide binding]; other site
316056000100	putative catalytic residues [active]
316056000101	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
316056000102	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
316056000103	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
316056000104	16S rRNA methyltransferase B; Provisional; Region: PRK10901
316056000105	NusB family; Region: NusB; pfam01029
316056000106	putative RNA binding site [nucleotide binding]; other site
316056000107	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056000108	S-adenosylmethionine binding site [chemical binding]; other site
316056000109	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
316056000110	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
316056000111	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
316056000112	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
316056000113	Staphylococcal nuclease homologues; Region: SNc; smart00318
316056000114	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
316056000115	Alkaline phosphatase homologues; Region: alkPPc; smart00098
316056000116	active site
316056000117	dimer interface [polypeptide binding]; other site
316056000118	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
316056000119	argininosuccinate synthase; Validated; Region: PRK05370
316056000120	argininosuccinate synthase; Provisional; Region: PRK13820
316056000121	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
316056000122	active site
316056000123	HD domain; Region: HD_3; pfam13023
316056000124	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
316056000125	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056000126	FeS/SAM binding site; other site
316056000127	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
316056000128	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
316056000129	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
316056000130	NAD(P) binding site [chemical binding]; other site
316056000131	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
316056000132	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056000133	Coenzyme A binding pocket [chemical binding]; other site
316056000134	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
316056000135	dimer interface [polypeptide binding]; other site
316056000136	substrate binding site [chemical binding]; other site
316056000137	metal binding sites [ion binding]; metal-binding site
316056000138	hypothetical protein; Provisional; Region: PRK08262
316056000139	M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674
316056000140	metal binding site [ion binding]; metal-binding site
316056000141	acetyl-CoA synthetase; Provisional; Region: PRK00174
316056000142	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
316056000143	active site
316056000144	CoA binding site [chemical binding]; other site
316056000145	acyl-activating enzyme (AAE) consensus motif; other site
316056000146	AMP binding site [chemical binding]; other site
316056000147	acetate binding site [chemical binding]; other site
316056000148	Predicted methyltransferase [General function prediction only]; Region: COG3897
316056000149	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
316056000150	EVE domain; Region: EVE; pfam01878
316056000151	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
316056000152	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
316056000153	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
316056000154	UGMP family protein; Validated; Region: PRK09604
316056000155	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
316056000156	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
316056000157	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
316056000158	active site
316056000159	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
316056000160	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
316056000161	Cytochrome P450; Region: p450; cl12078
316056000162	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
316056000163	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
316056000164	cyclase homology domain; Region: CHD; cd07302
316056000165	nucleotidyl binding site; other site
316056000166	metal binding site [ion binding]; metal-binding site
316056000167	dimer interface [polypeptide binding]; other site
316056000168	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
316056000169	putative metal binding site [ion binding]; other site
316056000170	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
316056000171	classical (c) SDRs; Region: SDR_c; cd05233
316056000172	NAD(P) binding site [chemical binding]; other site
316056000173	active site
316056000174	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
316056000175	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
316056000176	catalytic triad [active]
316056000177	YGGT family; Region: YGGT; pfam02325
316056000178	hypothetical protein; Validated; Region: PRK01310
316056000179	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
316056000180	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
316056000181	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
316056000182	homodimer interface [polypeptide binding]; other site
316056000183	NADP binding site [chemical binding]; other site
316056000184	substrate binding site [chemical binding]; other site
316056000185	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
316056000186	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316056000187	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056000188	dimer interface [polypeptide binding]; other site
316056000189	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056000190	putative CheW interface [polypeptide binding]; other site
316056000191	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
316056000192	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
316056000193	Active Sites [active]
316056000194	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
316056000195	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
316056000196	CysD dimerization site [polypeptide binding]; other site
316056000197	G1 box; other site
316056000198	putative GEF interaction site [polypeptide binding]; other site
316056000199	GTP/Mg2+ binding site [chemical binding]; other site
316056000200	Switch I region; other site
316056000201	G2 box; other site
316056000202	G3 box; other site
316056000203	Switch II region; other site
316056000204	G4 box; other site
316056000205	G5 box; other site
316056000206	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
316056000207	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
316056000208	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
316056000209	ligand-binding site [chemical binding]; other site
316056000210	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
316056000211	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
316056000212	ligand binding site [chemical binding]; other site
316056000213	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
316056000214	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
316056000215	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316056000216	catalytic loop [active]
316056000217	iron binding site [ion binding]; other site
316056000218	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
316056000219	L-aspartate oxidase; Provisional; Region: PRK06175
316056000220	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
316056000221	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
316056000222	putative SdhC subunit interface [polypeptide binding]; other site
316056000223	putative proximal heme binding site [chemical binding]; other site
316056000224	putative Iron-sulfur protein interface [polypeptide binding]; other site
316056000225	putative proximal quinone binding site; other site
316056000226	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
316056000227	Iron-sulfur protein interface; other site
316056000228	proximal quinone binding site [chemical binding]; other site
316056000229	SdhD (CybS) interface [polypeptide binding]; other site
316056000230	proximal heme binding site [chemical binding]; other site
316056000231	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
316056000232	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
316056000233	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
316056000234	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
316056000235	putative ligand binding site [chemical binding]; other site
316056000236	Protein of unknown function (DUF2023); Region: DUF2023; pfam09633
316056000237	flavodoxin FldA; Validated; Region: PRK09267
316056000238	MAPEG family; Region: MAPEG; pfam01124
316056000239	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
316056000240	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
316056000241	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
316056000242	Walker A/P-loop; other site
316056000243	ATP binding site [chemical binding]; other site
316056000244	Q-loop/lid; other site
316056000245	ABC transporter signature motif; other site
316056000246	Walker B; other site
316056000247	D-loop; other site
316056000248	H-loop/switch region; other site
316056000249	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
316056000250	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
316056000251	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316056000252	N-terminal plug; other site
316056000253	ligand-binding site [chemical binding]; other site
316056000254	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
316056000255	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
316056000256	ABC-ATPase subunit  interface; other site
316056000257	dimer interface [polypeptide binding]; other site
316056000258	putative PBP binding regions; other site
316056000259	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
316056000260	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
316056000261	Walker A/P-loop; other site
316056000262	ATP binding site [chemical binding]; other site
316056000263	Q-loop/lid; other site
316056000264	ABC transporter signature motif; other site
316056000265	Walker B; other site
316056000266	D-loop; other site
316056000267	H-loop/switch region; other site
316056000268	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
316056000269	intersubunit interface [polypeptide binding]; other site
316056000270	Protein of unknown function (DUF938); Region: DUF938; pfam06080
316056000271	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
316056000272	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
316056000273	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
316056000274	RNA polymerase sigma factor; Provisional; Region: PRK12515
316056000275	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316056000276	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316056000277	DNA binding residues [nucleotide binding]
316056000278	osmolarity response regulator; Provisional; Region: ompR; PRK09468
316056000279	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056000280	active site
316056000281	phosphorylation site [posttranslational modification]
316056000282	intermolecular recognition site; other site
316056000283	dimerization interface [polypeptide binding]; other site
316056000284	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056000285	DNA binding site [nucleotide binding]
316056000286	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
316056000287	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056000288	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056000289	dimer interface [polypeptide binding]; other site
316056000290	phosphorylation site [posttranslational modification]
316056000291	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056000292	ATP binding site [chemical binding]; other site
316056000293	Mg2+ binding site [ion binding]; other site
316056000294	G-X-G motif; other site
316056000295	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056000296	dimerization interface [polypeptide binding]; other site
316056000297	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056000298	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056000299	ATP binding site [chemical binding]; other site
316056000300	Mg2+ binding site [ion binding]; other site
316056000301	G-X-G motif; other site
316056000302	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
316056000303	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
316056000304	anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154
316056000305	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056000306	non-specific DNA binding site [nucleotide binding]; other site
316056000307	salt bridge; other site
316056000308	sequence-specific DNA binding site [nucleotide binding]; other site
316056000309	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
316056000310	ADP binding site [chemical binding]; other site
316056000311	magnesium binding site [ion binding]; other site
316056000312	putative shikimate binding site; other site
316056000313	S-formylglutathione hydrolase; Region: PLN02442
316056000314	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
316056000315	glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417
316056000316	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
316056000317	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
316056000318	substrate binding site [chemical binding]; other site
316056000319	catalytic Zn binding site [ion binding]; other site
316056000320	NAD binding site [chemical binding]; other site
316056000321	structural Zn binding site [ion binding]; other site
316056000322	dimer interface [polypeptide binding]; other site
316056000323	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
316056000324	succinic semialdehyde dehydrogenase; Region: PLN02278
316056000325	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
316056000326	tetramerization interface [polypeptide binding]; other site
316056000327	NAD(P) binding site [chemical binding]; other site
316056000328	catalytic residues [active]
316056000329	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
316056000330	6-hydroxyhexanoate dehydrogenase (HHD) catalyzes the oxidation of 6-hydroxyhexanoate to 6-oxohexanoate; Region: HHD; cd08191
316056000331	putative active site [active]
316056000332	metal binding site [ion binding]; metal-binding site
316056000333	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
316056000334	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
316056000335	classical (c) SDRs; Region: SDR_c; cd05233
316056000336	NAD(P) binding site [chemical binding]; other site
316056000337	active site
316056000338	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
316056000339	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
316056000340	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316056000341	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316056000342	TM-ABC transporter signature motif; other site
316056000343	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
316056000344	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316056000345	Walker A/P-loop; other site
316056000346	ATP binding site [chemical binding]; other site
316056000347	Q-loop/lid; other site
316056000348	ABC transporter signature motif; other site
316056000349	Walker B; other site
316056000350	D-loop; other site
316056000351	H-loop/switch region; other site
316056000352	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316056000353	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316056000354	TM-ABC transporter signature motif; other site
316056000355	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
316056000356	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316056000357	Walker A/P-loop; other site
316056000358	ATP binding site [chemical binding]; other site
316056000359	Q-loop/lid; other site
316056000360	ABC transporter signature motif; other site
316056000361	Walker B; other site
316056000362	D-loop; other site
316056000363	H-loop/switch region; other site
316056000364	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
316056000365	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
316056000366	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
316056000367	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
316056000368	Transcriptional regulator [Transcription]; Region: IclR; COG1414
316056000369	Bacterial transcriptional regulator; Region: IclR; pfam01614
316056000370	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
316056000371	putative dimer interface [polypeptide binding]; other site
316056000372	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
316056000373	Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956
316056000374	HNH endonuclease; Region: HNH_5; pfam14279
316056000375	Glycolipid 2-alpha-mannosyltransferase; Region: Glyco_transf_15; cl02091
316056000376	Phosphotransferase enzyme family; Region: APH; pfam01636
316056000377	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
316056000378	active site
316056000379	substrate binding site [chemical binding]; other site
316056000380	ATP binding site [chemical binding]; other site
316056000381	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
316056000382	nudix motif; other site
316056000383	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
316056000384	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
316056000385	homodimer interface [polypeptide binding]; other site
316056000386	substrate-cofactor binding pocket; other site
316056000387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056000388	catalytic residue [active]
316056000389	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
316056000390	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316056000391	motif II; other site
316056000392	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316056000393	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
316056000394	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316056000395	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
316056000396	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
316056000397	active site
316056000398	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056000399	S-adenosylmethionine binding site [chemical binding]; other site
316056000400	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
316056000401	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316056000402	Transposase; Region: HTH_Tnp_1; pfam01527
316056000403	Restriction endonuclease; Region: Mrr_cat; pfam04471
316056000404	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
316056000405	AAA domain; Region: AAA_33; pfam13671
316056000406	AAA domain; Region: AAA_17; pfam13207
316056000407	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
316056000408	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
316056000409	Methyltransferase domain; Region: Methyltransf_31; pfam13847
316056000410	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056000411	S-adenosylmethionine binding site [chemical binding]; other site
316056000412	Conjugal transfer protein TraD; Region: TraD; pfam06412
316056000413	Conjugal transfer protein TraD; Region: TraD; pfam06412
316056000414	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
316056000415	MobA/MobL family; Region: MobA_MobL; pfam03389
316056000416	AAA domain; Region: AAA_30; pfam13604
316056000417	Family description; Region: UvrD_C_2; pfam13538
316056000418	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
316056000419	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
316056000420	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
316056000421	active site
316056000422	Int/Topo IB signature motif; other site
316056000423	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
316056000424	nucleotide binding site [chemical binding]; other site
316056000425	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
316056000426	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
316056000427	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
316056000428	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
316056000429	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
316056000430	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
316056000431	GTPase CgtA; Reviewed; Region: obgE; PRK12299
316056000432	GTP1/OBG; Region: GTP1_OBG; pfam01018
316056000433	Obg GTPase; Region: Obg; cd01898
316056000434	G1 box; other site
316056000435	GTP/Mg2+ binding site [chemical binding]; other site
316056000436	Switch I region; other site
316056000437	G2 box; other site
316056000438	G3 box; other site
316056000439	Switch II region; other site
316056000440	G4 box; other site
316056000441	G5 box; other site
316056000442	gamma-glutamyl kinase; Provisional; Region: PRK05429
316056000443	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
316056000444	nucleotide binding site [chemical binding]; other site
316056000445	homotetrameric interface [polypeptide binding]; other site
316056000446	putative phosphate binding site [ion binding]; other site
316056000447	putative allosteric binding site; other site
316056000448	PUA domain; Region: PUA; pfam01472
316056000449	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
316056000450	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
316056000451	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
316056000452	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
316056000453	putative catalytic cysteine [active]
316056000454	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
316056000455	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
316056000456	active site
316056000457	(T/H)XGH motif; other site
316056000458	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
316056000459	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
316056000460	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
316056000461	Peptidase family M23; Region: Peptidase_M23; pfam01551
316056000462	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
316056000463	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
316056000464	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
316056000465	protein binding site [polypeptide binding]; other site
316056000466	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
316056000467	Catalytic dyad [active]
316056000468	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
316056000469	putative active site [active]
316056000470	NodB motif; other site
316056000471	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
316056000472	putative active site [active]
316056000473	Ap4A binding site [chemical binding]; other site
316056000474	nudix motif; other site
316056000475	putative metal binding site [ion binding]; other site
316056000476	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
316056000477	putative active site [active]
316056000478	Ap4A binding site [chemical binding]; other site
316056000479	nudix motif; other site
316056000480	putative metal binding site [ion binding]; other site
316056000481	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
316056000482	dimer interface [polypeptide binding]; other site
316056000483	active site
316056000484	Schiff base residues; other site
316056000485	Helix-turn-helix domain; Region: HTH_18; pfam12833
316056000486	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13448
316056000487	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
316056000488	gamma subunit interface [polypeptide binding]; other site
316056000489	epsilon subunit interface [polypeptide binding]; other site
316056000490	LBP interface [polypeptide binding]; other site
316056000491	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
316056000492	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
316056000493	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
316056000494	alpha subunit interaction interface [polypeptide binding]; other site
316056000495	Walker A motif; other site
316056000496	ATP binding site [chemical binding]; other site
316056000497	Walker B motif; other site
316056000498	inhibitor binding site; inhibition site
316056000499	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
316056000500	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
316056000501	core domain interface [polypeptide binding]; other site
316056000502	delta subunit interface [polypeptide binding]; other site
316056000503	epsilon subunit interface [polypeptide binding]; other site
316056000504	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
316056000505	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
316056000506	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
316056000507	beta subunit interaction interface [polypeptide binding]; other site
316056000508	Walker A motif; other site
316056000509	ATP binding site [chemical binding]; other site
316056000510	Walker B motif; other site
316056000511	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
316056000512	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
316056000513	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
316056000514	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
316056000515	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
316056000516	primosome assembly protein PriA; Validated; Region: PRK05580
316056000517	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316056000518	ATP binding site [chemical binding]; other site
316056000519	putative Mg++ binding site [ion binding]; other site
316056000520	helicase superfamily c-terminal domain; Region: HELICc; smart00490
316056000521	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
316056000522	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
316056000523	active site
316056000524	DNA binding site [nucleotide binding]
316056000525	Int/Topo IB signature motif; other site
316056000526	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
316056000527	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115
316056000528	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
316056000529	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316056000530	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
316056000531	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
316056000532	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
316056000533	short chain dehydrogenase; Provisional; Region: PRK06123
316056000534	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056000535	NAD(P) binding site [chemical binding]; other site
316056000536	active site
316056000537	MAPEG family; Region: MAPEG; cl09190
316056000538	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
316056000539	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
316056000540	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
316056000541	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
316056000542	E3 interaction surface; other site
316056000543	lipoyl attachment site [posttranslational modification]; other site
316056000544	e3 binding domain; Region: E3_binding; pfam02817
316056000545	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
316056000546	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
316056000547	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
316056000548	TPP-binding site [chemical binding]; other site
316056000549	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
316056000550	dimer interface [polypeptide binding]; other site
316056000551	PYR/PP interface [polypeptide binding]; other site
316056000552	TPP binding site [chemical binding]; other site
316056000553	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
316056000554	CoA binding domain; Region: CoA_binding; smart00881
316056000555	CoA-ligase; Region: Ligase_CoA; pfam00549
316056000556	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
316056000557	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
316056000558	CoA-ligase; Region: Ligase_CoA; pfam00549
316056000559	malate dehydrogenase; Reviewed; Region: PRK06223
316056000560	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
316056000561	NAD(P) binding site [chemical binding]; other site
316056000562	dimer interface [polypeptide binding]; other site
316056000563	tetramer (dimer of dimers) interface [polypeptide binding]; other site
316056000564	substrate binding site [chemical binding]; other site
316056000565	Predicted ATPase [General function prediction only]; Region: COG1485
316056000566	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
316056000567	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
316056000568	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
316056000569	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
316056000570	active site
316056000571	catalytic triad [active]
316056000572	oxyanion hole [active]
316056000573	switch loop; other site
316056000574	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
316056000575	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
316056000576	Walker A/P-loop; other site
316056000577	ATP binding site [chemical binding]; other site
316056000578	Q-loop/lid; other site
316056000579	ABC transporter signature motif; other site
316056000580	Walker B; other site
316056000581	D-loop; other site
316056000582	H-loop/switch region; other site
316056000583	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
316056000584	FtsX-like permease family; Region: FtsX; pfam02687
316056000585	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
316056000586	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
316056000587	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
316056000588	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056000589	Coenzyme A binding pocket [chemical binding]; other site
316056000590	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
316056000591	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
316056000592	aconitate hydratase; Validated; Region: PRK09277
316056000593	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
316056000594	substrate binding site [chemical binding]; other site
316056000595	ligand binding site [chemical binding]; other site
316056000596	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
316056000597	substrate binding site [chemical binding]; other site
316056000598	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
316056000599	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056000600	Q-loop/lid; other site
316056000601	ABC transporter signature motif; other site
316056000602	Walker B; other site
316056000603	D-loop; other site
316056000604	H-loop/switch region; other site
316056000605	heme exporter protein CcmB; Region: ccmB; TIGR01190
316056000606	heme exporter protein CcmC; Region: ccmC; TIGR01191
316056000607	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
316056000608	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
316056000609	catalytic residues [active]
316056000610	central insert; other site
316056000611	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
316056000612	intracellular septation protein A; Reviewed; Region: PRK00259
316056000613	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
316056000614	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
316056000615	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
316056000616	P loop; other site
316056000617	GTP binding site [chemical binding]; other site
316056000618	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
316056000619	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
316056000620	active site
316056000621	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
316056000622	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
316056000623	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056000624	FeS/SAM binding site; other site
316056000625	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
316056000626	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
316056000627	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
316056000628	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
316056000629	Uncharacterized conserved protein [Function unknown]; Region: COG2968
316056000630	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
316056000631	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
316056000632	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
316056000633	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
316056000634	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
316056000635	signal recognition particle protein; Provisional; Region: PRK10867
316056000636	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
316056000637	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
316056000638	P loop; other site
316056000639	GTP binding site [chemical binding]; other site
316056000640	Signal peptide binding domain; Region: SRP_SPB; pfam02978
316056000641	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
316056000642	RimM N-terminal domain; Region: RimM; pfam01782
316056000643	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
316056000644	PRC-barrel domain; Region: PRC; pfam05239
316056000645	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
316056000646	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
316056000647	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
316056000648	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
316056000649	substrate binding site [chemical binding]; other site
316056000650	ligand binding site [chemical binding]; other site
316056000651	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
316056000652	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
316056000653	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
316056000654	substrate binding site [chemical binding]; other site
316056000655	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056000656	non-specific DNA binding site [nucleotide binding]; other site
316056000657	salt bridge; other site
316056000658	sequence-specific DNA binding site [nucleotide binding]; other site
316056000659	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
316056000660	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
316056000661	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
316056000662	active site clefts [active]
316056000663	zinc binding site [ion binding]; other site
316056000664	dimer interface [polypeptide binding]; other site
316056000665	Protein of unknown function (DUF3072); Region: DUF3072; pfam11272
316056000666	hypothetical protein; Provisional; Region: PRK05208
316056000667	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
316056000668	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
316056000669	tartrate dehydrogenase; Region: TTC; TIGR02089
316056000670	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
316056000671	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
316056000672	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
316056000673	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
316056000674	Moco binding site; other site
316056000675	metal coordination site [ion binding]; other site
316056000676	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
316056000677	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
316056000678	Fasciclin domain; Region: Fasciclin; pfam02469
316056000679	malonyl-CoA synthase; Validated; Region: PRK07514
316056000680	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
316056000681	acyl-activating enzyme (AAE) consensus motif; other site
316056000682	active site
316056000683	AMP binding site [chemical binding]; other site
316056000684	CoA binding site [chemical binding]; other site
316056000685	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
316056000686	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056000687	NAD(P) binding site [chemical binding]; other site
316056000688	active site
316056000689	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
316056000690	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
316056000691	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
316056000692	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056000693	Walker A/P-loop; other site
316056000694	ATP binding site [chemical binding]; other site
316056000695	Q-loop/lid; other site
316056000696	ABC transporter signature motif; other site
316056000697	Walker B; other site
316056000698	D-loop; other site
316056000699	H-loop/switch region; other site
316056000700	ABC-2 type transporter; Region: ABC2_membrane; cl17235
316056000701	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
316056000702	Uncharacterized conserved protein [Function unknown]; Region: COG0432
316056000703	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
316056000704	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
316056000705	dimer interface [polypeptide binding]; other site
316056000706	catalytic residue [active]
316056000707	metal binding site [ion binding]; metal-binding site
316056000708	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
316056000709	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
316056000710	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
316056000711	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
316056000712	VWA-like domain (DUF2201); Region: DUF2201; pfam09967
316056000713	AAA domain; Region: AAA_14; pfam13173
316056000714	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
316056000715	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
316056000716	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
316056000717	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
316056000718	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
316056000719	RNA binding site [nucleotide binding]; other site
316056000720	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
316056000721	putative chaperone; Provisional; Region: PRK11678
316056000722	nucleotide binding site [chemical binding]; other site
316056000723	putative NEF/HSP70 interaction site [polypeptide binding]; other site
316056000724	SBD interface [polypeptide binding]; other site
316056000725	B12 binding domain; Region: B12-binding_2; pfam02607
316056000726	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
316056000727	HAMP domain; Region: HAMP; pfam00672
316056000728	dimerization interface [polypeptide binding]; other site
316056000729	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
316056000730	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
316056000731	catalytic residues [active]
316056000732	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
316056000733	Uncharacterized conserved protein [Function unknown]; Region: COG2835
316056000734	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
316056000735	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
316056000736	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
316056000737	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
316056000738	active site
316056000739	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
316056000740	catalytic triad [active]
316056000741	dimer interface [polypeptide binding]; other site
316056000742	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
316056000743	Nitrogen regulatory protein P-II; Region: P-II; smart00938
316056000744	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
316056000745	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
316056000746	Nitrogen regulatory protein P-II; Region: P-II; smart00938
316056000747	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
316056000748	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
316056000749	active site
316056000750	NTP binding site [chemical binding]; other site
316056000751	metal binding triad [ion binding]; metal-binding site
316056000752	antibiotic binding site [chemical binding]; other site
316056000753	Protein of unknown function DUF86; Region: DUF86; cl01031
316056000754	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
316056000755	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316056000756	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056000757	homodimer interface [polypeptide binding]; other site
316056000758	catalytic residue [active]
316056000759	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
316056000760	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
316056000761	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
316056000762	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
316056000763	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
316056000764	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
316056000765	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
316056000766	putative catalytic site [active]
316056000767	putative phosphate binding site [ion binding]; other site
316056000768	active site
316056000769	metal binding site A [ion binding]; metal-binding site
316056000770	DNA binding site [nucleotide binding]
316056000771	putative AP binding site [nucleotide binding]; other site
316056000772	putative metal binding site B [ion binding]; other site
316056000773	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056000774	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056000775	ligand binding site [chemical binding]; other site
316056000776	flexible hinge region; other site
316056000777	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316056000778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056000779	active site
316056000780	phosphorylation site [posttranslational modification]
316056000781	intermolecular recognition site; other site
316056000782	dimerization interface [polypeptide binding]; other site
316056000783	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056000784	DNA binding site [nucleotide binding]
316056000785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
316056000786	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
316056000787	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
316056000788	catalytic residue [active]
316056000789	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056000790	dimerization interface [polypeptide binding]; other site
316056000791	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056000792	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056000793	metal binding site [ion binding]; metal-binding site
316056000794	active site
316056000795	I-site; other site
316056000796	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
316056000797	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
316056000798	HIGH motif; other site
316056000799	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
316056000800	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
316056000801	active site
316056000802	KMSKS motif; other site
316056000803	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
316056000804	tRNA binding surface [nucleotide binding]; other site
316056000805	Lipopolysaccharide-assembly; Region: LptE; pfam04390
316056000806	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
316056000807	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
316056000808	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
316056000809	ParB-like nuclease domain; Region: ParB; smart00470
316056000810	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
316056000811	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
316056000812	P-loop; other site
316056000813	Magnesium ion binding site [ion binding]; other site
316056000814	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
316056000815	Magnesium ion binding site [ion binding]; other site
316056000816	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
316056000817	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
316056000818	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
316056000819	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
316056000820	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
316056000821	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
316056000822	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
316056000823	trmE is a tRNA modification GTPase; Region: trmE; cd04164
316056000824	G1 box; other site
316056000825	GTP/Mg2+ binding site [chemical binding]; other site
316056000826	Switch I region; other site
316056000827	G2 box; other site
316056000828	Switch II region; other site
316056000829	G3 box; other site
316056000830	G4 box; other site
316056000831	G5 box; other site
316056000832	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
316056000833	transcription termination factor Rho; Provisional; Region: rho; PRK09376
316056000834	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
316056000835	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
316056000836	RNA binding site [nucleotide binding]; other site
316056000837	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
316056000838	multimer interface [polypeptide binding]; other site
316056000839	Walker A motif; other site
316056000840	ATP binding site [chemical binding]; other site
316056000841	Walker B motif; other site
316056000842	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
316056000843	PEP synthetase regulatory protein; Provisional; Region: PRK05339
316056000844	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
316056000845	active site
316056000846	dimer interface [polypeptide binding]; other site
316056000847	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
316056000848	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
316056000849	CoA-binding site [chemical binding]; other site
316056000850	ATP-binding [chemical binding]; other site
316056000851	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
316056000852	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
316056000853	active site
316056000854	catalytic site [active]
316056000855	substrate binding site [chemical binding]; other site
316056000856	preprotein translocase subunit SecB; Validated; Region: PRK05751
316056000857	SecA binding site; other site
316056000858	Preprotein binding site; other site
316056000859	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
316056000860	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
316056000861	MltA specific insert domain; Region: MltA; smart00925
316056000862	3D domain; Region: 3D; pfam06725
316056000863	Smr domain; Region: Smr; pfam01713
316056000864	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
316056000865	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056000866	Walker A motif; other site
316056000867	ATP binding site [chemical binding]; other site
316056000868	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
316056000869	Walker B motif; other site
316056000870	arginine finger; other site
316056000871	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
316056000872	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
316056000873	active site
316056000874	HslU subunit interaction site [polypeptide binding]; other site
316056000875	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
316056000876	putative active site pocket [active]
316056000877	4-fold oligomerization interface [polypeptide binding]; other site
316056000878	metal binding residues [ion binding]; metal-binding site
316056000879	3-fold/trimer interface [polypeptide binding]; other site
316056000880	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
316056000881	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
316056000882	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
316056000883	putative active site [active]
316056000884	oxyanion strand; other site
316056000885	catalytic triad [active]
316056000886	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
316056000887	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
316056000888	catalytic residues [active]
316056000889	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
316056000890	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
316056000891	substrate binding site [chemical binding]; other site
316056000892	glutamase interaction surface [polypeptide binding]; other site
316056000893	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
316056000894	metal binding site [ion binding]; metal-binding site
316056000895	pantothenate kinase; Provisional; Region: PRK05439
316056000896	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
316056000897	ATP-binding site [chemical binding]; other site
316056000898	CoA-binding site [chemical binding]; other site
316056000899	Mg2+-binding site [ion binding]; other site
316056000900	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
316056000901	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056000902	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
316056000903	putative active site [active]
316056000904	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056000905	dimer interface [polypeptide binding]; other site
316056000906	phosphorylation site [posttranslational modification]
316056000907	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056000908	ATP binding site [chemical binding]; other site
316056000909	Mg2+ binding site [ion binding]; other site
316056000910	G-X-G motif; other site
316056000911	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
316056000912	Response regulator receiver domain; Region: Response_reg; pfam00072
316056000913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056000914	active site
316056000915	phosphorylation site [posttranslational modification]
316056000916	intermolecular recognition site; other site
316056000917	dimerization interface [polypeptide binding]; other site
316056000918	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
316056000919	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
316056000920	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
316056000921	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
316056000922	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056000923	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056000924	metal binding site [ion binding]; metal-binding site
316056000925	active site
316056000926	I-site; other site
316056000927	glutathione synthetase; Provisional; Region: PRK05246
316056000928	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
316056000929	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
316056000930	hypothetical protein; Reviewed; Region: PRK12497
316056000931	Predicted methyltransferases [General function prediction only]; Region: COG0313
316056000932	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
316056000933	putative SAM binding site [chemical binding]; other site
316056000934	putative homodimer interface [polypeptide binding]; other site
316056000935	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
316056000936	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
316056000937	putative ligand binding site [chemical binding]; other site
316056000938	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
316056000939	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056000940	FeS/SAM binding site; other site
316056000941	HemN C-terminal domain; Region: HemN_C; pfam06969
316056000942	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
316056000943	active site
316056000944	dimerization interface [polypeptide binding]; other site
316056000945	ribonuclease PH; Reviewed; Region: rph; PRK00173
316056000946	Ribonuclease PH; Region: RNase_PH_bact; cd11362
316056000947	hexamer interface [polypeptide binding]; other site
316056000948	active site
316056000949	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
316056000950	heat shock protein GrpE; Provisional; Region: PRK14141
316056000951	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
316056000952	dimer interface [polypeptide binding]; other site
316056000953	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
316056000954	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
316056000955	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
316056000956	nucleotide binding site [chemical binding]; other site
316056000957	NEF interaction site [polypeptide binding]; other site
316056000958	SBD interface [polypeptide binding]; other site
316056000959	chaperone protein DnaJ; Provisional; Region: PRK10767
316056000960	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
316056000961	HSP70 interaction site [polypeptide binding]; other site
316056000962	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
316056000963	substrate binding site [polypeptide binding]; other site
316056000964	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
316056000965	Zn binding sites [ion binding]; other site
316056000966	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
316056000967	dimer interface [polypeptide binding]; other site
316056000968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056000969	S-adenosylmethionine binding site [chemical binding]; other site
316056000970	Predicted flavoprotein [General function prediction only]; Region: COG0431
316056000971	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
316056000972	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
316056000973	active site
316056000974	dimer interface [polypeptide binding]; other site
316056000975	Uncharacterized conserved protein [Function unknown]; Region: COG5470
316056000976	dihydrodipicolinate reductase; Provisional; Region: PRK00048
316056000977	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
316056000978	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
316056000979	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
316056000980	catalytic core [active]
316056000981	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
316056000982	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
316056000983	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
316056000984	DNA binding site [nucleotide binding]
316056000985	active site
316056000986	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
316056000987	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
316056000988	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
316056000989	minor groove reading motif; other site
316056000990	helix-hairpin-helix signature motif; other site
316056000991	substrate binding pocket [chemical binding]; other site
316056000992	active site
316056000993	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
316056000994	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
316056000995	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
316056000996	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
316056000997	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
316056000998	PII uridylyl-transferase; Provisional; Region: PRK05092
316056000999	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
316056001000	metal binding triad; other site
316056001001	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
316056001002	HD domain; Region: HD; pfam01966
316056001003	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
316056001004	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
316056001005	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
316056001006	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056001007	substrate binding site [chemical binding]; other site
316056001008	oxyanion hole (OAH) forming residues; other site
316056001009	trimer interface [polypeptide binding]; other site
316056001010	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
316056001011	ATP binding site [chemical binding]; other site
316056001012	active site
316056001013	substrate binding site [chemical binding]; other site
316056001014	Pirin-related protein [General function prediction only]; Region: COG1741
316056001015	Pirin; Region: Pirin; pfam02678
316056001016	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
316056001017	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
316056001018	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
316056001019	NAD binding site [chemical binding]; other site
316056001020	homotetramer interface [polypeptide binding]; other site
316056001021	homodimer interface [polypeptide binding]; other site
316056001022	substrate binding site [chemical binding]; other site
316056001023	active site
316056001024	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
316056001025	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
316056001026	dimer interface [polypeptide binding]; other site
316056001027	active site
316056001028	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
316056001029	active site 1 [active]
316056001030	dimer interface [polypeptide binding]; other site
316056001031	active site 2 [active]
316056001032	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
316056001033	metal binding site 2 [ion binding]; metal-binding site
316056001034	putative DNA binding helix; other site
316056001035	metal binding site 1 [ion binding]; metal-binding site
316056001036	dimer interface [polypeptide binding]; other site
316056001037	structural Zn2+ binding site [ion binding]; other site
316056001038	Bacterial SH3 domain; Region: SH3_4; pfam06347
316056001039	Bacterial SH3 domain; Region: SH3_4; pfam06347
316056001040	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
316056001041	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
316056001042	dimerization interface [polypeptide binding]; other site
316056001043	ligand binding site [chemical binding]; other site
316056001044	NADP binding site [chemical binding]; other site
316056001045	catalytic site [active]
316056001046	Protein of unknown function DUF45; Region: DUF45; pfam01863
316056001047	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
316056001048	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
316056001049	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316056001050	ABC-2 type transporter; Region: ABC2_membrane; cl17235
316056001051	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
316056001052	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316056001053	Walker A/P-loop; other site
316056001054	ATP binding site [chemical binding]; other site
316056001055	Q-loop/lid; other site
316056001056	ABC transporter signature motif; other site
316056001057	Walker B; other site
316056001058	D-loop; other site
316056001059	H-loop/switch region; other site
316056001060	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056001061	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056001062	dimer interface [polypeptide binding]; other site
316056001063	phosphorylation site [posttranslational modification]
316056001064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056001065	ATP binding site [chemical binding]; other site
316056001066	Mg2+ binding site [ion binding]; other site
316056001067	G-X-G motif; other site
316056001068	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
316056001069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056001070	active site
316056001071	phosphorylation site [posttranslational modification]
316056001072	intermolecular recognition site; other site
316056001073	dimerization interface [polypeptide binding]; other site
316056001074	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
316056001075	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
316056001076	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
316056001077	dimer interface [polypeptide binding]; other site
316056001078	active site
316056001079	heme binding site [chemical binding]; other site
316056001080	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
316056001081	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
316056001082	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056001083	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
316056001084	dimerization interface [polypeptide binding]; other site
316056001085	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
316056001086	MutS domain I; Region: MutS_I; pfam01624
316056001087	MutS domain II; Region: MutS_II; pfam05188
316056001088	MutS domain III; Region: MutS_III; pfam05192
316056001089	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
316056001090	Walker A/P-loop; other site
316056001091	ATP binding site [chemical binding]; other site
316056001092	Q-loop/lid; other site
316056001093	ABC transporter signature motif; other site
316056001094	Walker B; other site
316056001095	D-loop; other site
316056001096	H-loop/switch region; other site
316056001097	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
316056001098	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
316056001099	ATP binding site [chemical binding]; other site
316056001100	substrate interface [chemical binding]; other site
316056001101	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
316056001102	GAF domain; Region: GAF; pfam01590
316056001103	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056001104	dimer interface [polypeptide binding]; other site
316056001105	phosphorylation site [posttranslational modification]
316056001106	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056001107	ATP binding site [chemical binding]; other site
316056001108	G-X-G motif; other site
316056001109	Response regulator receiver domain; Region: Response_reg; pfam00072
316056001110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056001111	active site
316056001112	phosphorylation site [posttranslational modification]
316056001113	intermolecular recognition site; other site
316056001114	dimerization interface [polypeptide binding]; other site
316056001115	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
316056001116	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
316056001117	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
316056001118	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
316056001119	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
316056001120	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
316056001121	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
316056001122	Protein of unknown function (DUF1052); Region: DUF1052; pfam06319
316056001123	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
316056001124	GIY-YIG motif/motif A; other site
316056001125	putative active site [active]
316056001126	putative metal binding site [ion binding]; other site
316056001127	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
316056001128	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
316056001129	DNA binding site [nucleotide binding]
316056001130	catalytic residue [active]
316056001131	H2TH interface [polypeptide binding]; other site
316056001132	putative catalytic residues [active]
316056001133	turnover-facilitating residue; other site
316056001134	intercalation triad [nucleotide binding]; other site
316056001135	8OG recognition residue [nucleotide binding]; other site
316056001136	putative reading head residues; other site
316056001137	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
316056001138	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
316056001139	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
316056001140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056001141	S-adenosylmethionine binding site [chemical binding]; other site
316056001142	ABC1 family; Region: ABC1; cl17513
316056001143	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
316056001144	bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982
316056001145	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
316056001146	Flavoprotein; Region: Flavoprotein; pfam02441
316056001147	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
316056001148	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
316056001149	trimer interface [polypeptide binding]; other site
316056001150	active site
316056001151	PAS fold; Region: PAS_7; pfam12860
316056001152	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
316056001153	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056001154	dimer interface [polypeptide binding]; other site
316056001155	phosphorylation site [posttranslational modification]
316056001156	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056001157	ATP binding site [chemical binding]; other site
316056001158	Mg2+ binding site [ion binding]; other site
316056001159	G-X-G motif; other site
316056001160	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
316056001161	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
316056001162	Phosphotransferase enzyme family; Region: APH; pfam01636
316056001163	PilZ domain; Region: PilZ; pfam07238
316056001164	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
316056001165	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
316056001166	Substrate binding site; other site
316056001167	metal-binding site
316056001168	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
316056001169	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
316056001170	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
316056001171	Part of AAA domain; Region: AAA_19; pfam13245
316056001172	Family description; Region: UvrD_C_2; pfam13538
316056001173	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
316056001174	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
316056001175	catalytic residues [active]
316056001176	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
316056001177	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
316056001178	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
316056001179	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
316056001180	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
316056001181	substrate binding site [chemical binding]; other site
316056001182	active site
316056001183	catalytic residues [active]
316056001184	heterodimer interface [polypeptide binding]; other site
316056001185	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
316056001186	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
316056001187	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056001188	catalytic residue [active]
316056001189	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
316056001190	active site
316056001191	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
316056001192	IHF dimer interface [polypeptide binding]; other site
316056001193	IHF - DNA interface [nucleotide binding]; other site
316056001194	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
316056001195	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
316056001196	tandem repeat interface [polypeptide binding]; other site
316056001197	oligomer interface [polypeptide binding]; other site
316056001198	active site residues [active]
316056001199	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
316056001200	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
316056001201	RNA binding site [nucleotide binding]; other site
316056001202	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
316056001203	RNA binding site [nucleotide binding]; other site
316056001204	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
316056001205	RNA binding site [nucleotide binding]; other site
316056001206	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
316056001207	RNA binding site [nucleotide binding]; other site
316056001208	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
316056001209	RNA binding site [nucleotide binding]; other site
316056001210	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
316056001211	RNA binding site [nucleotide binding]; other site
316056001212	cytidylate kinase; Provisional; Region: cmk; PRK00023
316056001213	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
316056001214	CMP-binding site; other site
316056001215	The sites determining sugar specificity; other site
316056001216	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
316056001217	putative acyl-acceptor binding pocket; other site
316056001218	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
316056001219	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
316056001220	hinge; other site
316056001221	active site
316056001222	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
316056001223	TIGR02300 family protein; Region: FYDLN_acid
316056001224	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
316056001225	GIY-YIG motif/motif A; other site
316056001226	putative active site [active]
316056001227	putative metal binding site [ion binding]; other site
316056001228	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
316056001229	CoA-transferase family III; Region: CoA_transf_3; pfam02515
316056001230	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
316056001231	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
316056001232	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
316056001233	putative active site [active]
316056001234	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
316056001235	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056001236	putative PBP binding loops; other site
316056001237	ABC-ATPase subunit interface; other site
316056001238	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
316056001239	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056001240	dimer interface [polypeptide binding]; other site
316056001241	conserved gate region; other site
316056001242	putative PBP binding loops; other site
316056001243	ABC-ATPase subunit interface; other site
316056001244	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
316056001245	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
316056001246	Walker A/P-loop; other site
316056001247	ATP binding site [chemical binding]; other site
316056001248	Q-loop/lid; other site
316056001249	ABC transporter signature motif; other site
316056001250	Walker B; other site
316056001251	D-loop; other site
316056001252	H-loop/switch region; other site
316056001253	TOBE domain; Region: TOBE_2; pfam08402
316056001254	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
316056001255	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
316056001256	putative dimer interface [polypeptide binding]; other site
316056001257	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
316056001258	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
316056001259	Predicted membrane protein [Function unknown]; Region: COG1971
316056001260	Domain of unknown function DUF; Region: DUF204; pfam02659
316056001261	Domain of unknown function DUF; Region: DUF204; pfam02659
316056001262	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
316056001263	active site
316056001264	phosphorylation site [posttranslational modification]
316056001265	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
316056001266	30S subunit binding site; other site
316056001267	RNA polymerase factor sigma-54; Provisional; Region: PRK12469
316056001268	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
316056001269	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
316056001270	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
316056001271	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
316056001272	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
316056001273	Walker A/P-loop; other site
316056001274	ATP binding site [chemical binding]; other site
316056001275	Q-loop/lid; other site
316056001276	ABC transporter signature motif; other site
316056001277	Walker B; other site
316056001278	D-loop; other site
316056001279	H-loop/switch region; other site
316056001280	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
316056001281	OstA-like protein; Region: OstA; pfam03968
316056001282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
316056001283	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
316056001284	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
316056001285	catalytic site [active]
316056001286	putative active site [active]
316056001287	putative substrate binding site [chemical binding]; other site
316056001288	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
316056001289	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
316056001290	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
316056001291	active site
316056001292	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
316056001293	HipA-like N-terminal domain; Region: HipA_N; pfam07805
316056001294	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
316056001295	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
316056001296	Catalytic site; other site
316056001297	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
316056001298	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
316056001299	NodB motif; other site
316056001300	active site
316056001301	catalytic site [active]
316056001302	metal binding site [ion binding]; metal-binding site
316056001303	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
316056001304	dinuclear metal binding motif [ion binding]; other site
316056001305	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
316056001306	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
316056001307	4Fe-4S binding domain; Region: Fer4_5; pfam12801
316056001308	nitrous-oxide reductase; Validated; Region: PRK02888
316056001309	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
316056001310	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
316056001311	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
316056001312	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316056001313	Walker A/P-loop; other site
316056001314	ATP binding site [chemical binding]; other site
316056001315	Q-loop/lid; other site
316056001316	ABC transporter signature motif; other site
316056001317	Walker B; other site
316056001318	D-loop; other site
316056001319	H-loop/switch region; other site
316056001320	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
316056001321	NosL; Region: NosL; pfam05573
316056001322	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
316056001323	ApbE family; Region: ApbE; pfam02424
316056001324	RES domain; Region: RES; pfam08808
316056001325	non-specific DNA binding site [nucleotide binding]; other site
316056001326	Helix-turn-helix; Region: HTH_3; pfam01381
316056001327	salt bridge; other site
316056001328	sequence-specific DNA binding site [nucleotide binding]; other site
316056001329	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
316056001330	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
316056001331	active site
316056001332	Int/Topo IB signature motif; other site
316056001333	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
316056001334	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
316056001335	putative NAD(P) binding site [chemical binding]; other site
316056001336	active site
316056001337	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
316056001338	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
316056001339	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
316056001340	C-terminal domain interface [polypeptide binding]; other site
316056001341	GSH binding site (G-site) [chemical binding]; other site
316056001342	dimer interface [polypeptide binding]; other site
316056001343	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
316056001344	N-terminal domain interface [polypeptide binding]; other site
316056001345	dimer interface [polypeptide binding]; other site
316056001346	substrate binding pocket (H-site) [chemical binding]; other site
316056001347	epoxyqueuosine reductase; Region: TIGR00276
316056001348	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
316056001349	CysZ-like protein; Reviewed; Region: PRK12768
316056001350	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
316056001351	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
316056001352	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
316056001353	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
316056001354	putative tRNA-binding site [nucleotide binding]; other site
316056001355	B3/4 domain; Region: B3_4; pfam03483
316056001356	tRNA synthetase B5 domain; Region: B5; smart00874
316056001357	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
316056001358	motif 1; other site
316056001359	dimer interface [polypeptide binding]; other site
316056001360	motif 3; other site
316056001361	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
316056001362	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
316056001363	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
316056001364	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
316056001365	dimer interface [polypeptide binding]; other site
316056001366	motif 1; other site
316056001367	active site
316056001368	motif 2; other site
316056001369	motif 3; other site
316056001370	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
316056001371	23S rRNA binding site [nucleotide binding]; other site
316056001372	L21 binding site [polypeptide binding]; other site
316056001373	L13 binding site [polypeptide binding]; other site
316056001374	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
316056001375	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316056001376	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316056001377	active site
316056001378	catalytic tetrad [active]
316056001379	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056001380	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056001381	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
316056001382	putative effector binding pocket; other site
316056001383	putative dimerization interface [polypeptide binding]; other site
316056001384	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
316056001385	Transglycosylase; Region: Transgly; pfam00912
316056001386	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
316056001387	succinic semialdehyde dehydrogenase; Region: PLN02278
316056001388	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
316056001389	tetramerization interface [polypeptide binding]; other site
316056001390	NAD(P) binding site [chemical binding]; other site
316056001391	catalytic residues [active]
316056001392	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
316056001393	Beta-lactamase; Region: Beta-lactamase; pfam00144
316056001394	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
316056001395	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
316056001396	substrate binding site [chemical binding]; other site
316056001397	ATP binding site [chemical binding]; other site
316056001398	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
316056001399	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
316056001400	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
316056001401	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
316056001402	active site
316056001403	HIGH motif; other site
316056001404	dimer interface [polypeptide binding]; other site
316056001405	KMSKS motif; other site
316056001406	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316056001407	Ligand Binding Site [chemical binding]; other site
316056001408	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
316056001409	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056001410	Walker A/P-loop; other site
316056001411	ATP binding site [chemical binding]; other site
316056001412	Q-loop/lid; other site
316056001413	ABC transporter signature motif; other site
316056001414	Walker B; other site
316056001415	D-loop; other site
316056001416	H-loop/switch region; other site
316056001417	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316056001418	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
316056001419	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
316056001420	dimer interface [polypeptide binding]; other site
316056001421	active site
316056001422	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
316056001423	substrate binding site [chemical binding]; other site
316056001424	catalytic residue [active]
316056001425	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
316056001426	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
316056001427	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
316056001428	Glycoprotease family; Region: Peptidase_M22; pfam00814
316056001429	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
316056001430	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056001431	Coenzyme A binding pocket [chemical binding]; other site
316056001432	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
316056001433	metal binding site 2 [ion binding]; metal-binding site
316056001434	putative DNA binding helix; other site
316056001435	metal binding site 1 [ion binding]; metal-binding site
316056001436	dimer interface [polypeptide binding]; other site
316056001437	structural Zn2+ binding site [ion binding]; other site
316056001438	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
316056001439	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316056001440	motif II; other site
316056001441	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
316056001442	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
316056001443	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056001444	FeS/SAM binding site; other site
316056001445	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
316056001446	PhoH-like protein; Region: PhoH; pfam02562
316056001447	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
316056001448	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
316056001449	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
316056001450	Transporter associated domain; Region: CorC_HlyC; smart01091
316056001451	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
316056001452	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
316056001453	putative active site [active]
316056001454	catalytic triad [active]
316056001455	putative dimer interface [polypeptide binding]; other site
316056001456	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
316056001457	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056001458	non-specific DNA binding site [nucleotide binding]; other site
316056001459	salt bridge; other site
316056001460	sequence-specific DNA binding site [nucleotide binding]; other site
316056001461	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
316056001462	Predicted ester cyclase [General function prediction only]; Region: COG5485
316056001463	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
316056001464	ribosome maturation protein RimP; Reviewed; Region: PRK00092
316056001465	Sm and related proteins; Region: Sm_like; cl00259
316056001466	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
316056001467	putative oligomer interface [polypeptide binding]; other site
316056001468	putative RNA binding site [nucleotide binding]; other site
316056001469	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
316056001470	NusA N-terminal domain; Region: NusA_N; pfam08529
316056001471	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
316056001472	RNA binding site [nucleotide binding]; other site
316056001473	homodimer interface [polypeptide binding]; other site
316056001474	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
316056001475	G-X-X-G motif; other site
316056001476	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
316056001477	G-X-X-G motif; other site
316056001478	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
316056001479	hypothetical protein; Provisional; Region: PRK09190
316056001480	Protein of unknown function (DUF448); Region: DUF448; pfam04296
316056001481	putative RNA binding cleft [nucleotide binding]; other site
316056001482	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
316056001483	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
316056001484	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
316056001485	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
316056001486	G1 box; other site
316056001487	putative GEF interaction site [polypeptide binding]; other site
316056001488	GTP/Mg2+ binding site [chemical binding]; other site
316056001489	Switch I region; other site
316056001490	G2 box; other site
316056001491	G3 box; other site
316056001492	Switch II region; other site
316056001493	G4 box; other site
316056001494	G5 box; other site
316056001495	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
316056001496	Translation-initiation factor 2; Region: IF-2; pfam11987
316056001497	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
316056001498	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
316056001499	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
316056001500	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
316056001501	RNA binding site [nucleotide binding]; other site
316056001502	active site
316056001503	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
316056001504	16S/18S rRNA binding site [nucleotide binding]; other site
316056001505	S13e-L30e interaction site [polypeptide binding]; other site
316056001506	25S rRNA binding site [nucleotide binding]; other site
316056001507	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
316056001508	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
316056001509	RNase E interface [polypeptide binding]; other site
316056001510	trimer interface [polypeptide binding]; other site
316056001511	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
316056001512	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
316056001513	RNase E interface [polypeptide binding]; other site
316056001514	trimer interface [polypeptide binding]; other site
316056001515	active site
316056001516	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
316056001517	putative nucleic acid binding region [nucleotide binding]; other site
316056001518	G-X-X-G motif; other site
316056001519	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
316056001520	RNA binding site [nucleotide binding]; other site
316056001521	domain interface; other site
316056001522	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
316056001523	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
316056001524	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
316056001525	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056001526	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316056001527	putative substrate translocation pore; other site
316056001528	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056001529	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
316056001530	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056001531	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056001532	Transcriptional regulators [Transcription]; Region: MarR; COG1846
316056001533	MarR family; Region: MarR; pfam01047
316056001534	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
316056001535	metal binding site 2 [ion binding]; metal-binding site
316056001536	putative DNA binding helix; other site
316056001537	metal binding site 1 [ion binding]; metal-binding site
316056001538	dimer interface [polypeptide binding]; other site
316056001539	structural Zn2+ binding site [ion binding]; other site
316056001540	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
316056001541	EamA-like transporter family; Region: EamA; pfam00892
316056001542	EamA-like transporter family; Region: EamA; pfam00892
316056001543	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
316056001544	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
316056001545	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
316056001546	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
316056001547	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056001548	metal binding site [ion binding]; metal-binding site
316056001549	active site
316056001550	I-site; other site
316056001551	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056001552	Sensors of blue-light using FAD; Region: BLUF; smart01034
316056001553	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
316056001554	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
316056001555	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
316056001556	substrate binding pocket [chemical binding]; other site
316056001557	chain length determination region; other site
316056001558	substrate-Mg2+ binding site; other site
316056001559	catalytic residues [active]
316056001560	aspartate-rich region 1; other site
316056001561	active site lid residues [active]
316056001562	aspartate-rich region 2; other site
316056001563	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
316056001564	Transglycosylase; Region: Transgly; cl17702
316056001565	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
316056001566	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056001567	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056001568	metal binding site [ion binding]; metal-binding site
316056001569	active site
316056001570	I-site; other site
316056001571	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056001572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
316056001573	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
316056001574	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
316056001575	putative acyltransferase; Provisional; Region: PRK05790
316056001576	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
316056001577	dimer interface [polypeptide binding]; other site
316056001578	active site
316056001579	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
316056001580	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
316056001581	NAD(P) binding site [chemical binding]; other site
316056001582	homotetramer interface [polypeptide binding]; other site
316056001583	homodimer interface [polypeptide binding]; other site
316056001584	active site
316056001585	EamA-like transporter family; Region: EamA; pfam00892
316056001586	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
316056001587	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
316056001588	Methyltransferase domain; Region: Methyltransf_23; pfam13489
316056001589	Methyltransferase domain; Region: Methyltransf_11; pfam08241
316056001590	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
316056001591	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
316056001592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056001593	S-adenosylmethionine binding site [chemical binding]; other site
316056001594	peptide chain release factor 1; Validated; Region: prfA; PRK00591
316056001595	This domain is found in peptide chain release factors; Region: PCRF; smart00937
316056001596	RF-1 domain; Region: RF-1; pfam00472
316056001597	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
316056001598	GAF domain; Region: GAF; pfam01590
316056001599	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
316056001600	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
316056001601	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
316056001602	aspartate kinase; Reviewed; Region: PRK06635
316056001603	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
316056001604	putative nucleotide binding site [chemical binding]; other site
316056001605	putative catalytic residues [active]
316056001606	putative Mg ion binding site [ion binding]; other site
316056001607	putative aspartate binding site [chemical binding]; other site
316056001608	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
316056001609	putative allosteric regulatory site; other site
316056001610	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
316056001611	putative allosteric regulatory residue; other site
316056001612	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
316056001613	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056001614	S-adenosylmethionine binding site [chemical binding]; other site
316056001615	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
316056001616	Predicted amidohydrolase [General function prediction only]; Region: COG0388
316056001617	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
316056001618	putative active site [active]
316056001619	catalytic triad [active]
316056001620	dimer interface [polypeptide binding]; other site
316056001621	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
316056001622	GSH binding site [chemical binding]; other site
316056001623	catalytic residues [active]
316056001624	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
316056001625	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
316056001626	active site
316056001627	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
316056001628	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056001629	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
316056001630	active site
316056001631	8-oxo-dGMP binding site [chemical binding]; other site
316056001632	nudix motif; other site
316056001633	metal binding site [ion binding]; metal-binding site
316056001634	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
316056001635	heterotetramer interface [polypeptide binding]; other site
316056001636	active site pocket [active]
316056001637	cleavage site
316056001638	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
316056001639	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
316056001640	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
316056001641	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
316056001642	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
316056001643	SEC-C motif; Region: SEC-C; pfam02810
316056001644	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
316056001645	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
316056001646	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
316056001647	Predicted transcriptional regulators [Transcription]; Region: COG1695
316056001648	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
316056001649	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
316056001650	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
316056001651	active site
316056001652	DNA binding site [nucleotide binding]
316056001653	Int/Topo IB signature motif; other site
316056001654	shikimate kinase; Provisional; Region: PRK13946
316056001655	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
316056001656	ADP binding site [chemical binding]; other site
316056001657	magnesium binding site [ion binding]; other site
316056001658	putative shikimate binding site; other site
316056001659	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
316056001660	active site
316056001661	dimer interface [polypeptide binding]; other site
316056001662	metal binding site [ion binding]; metal-binding site
316056001663	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
316056001664	Domain of unknown function DUF21; Region: DUF21; pfam01595
316056001665	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
316056001666	Transporter associated domain; Region: CorC_HlyC; smart01091
316056001667	BolA-like protein; Region: BolA; pfam01722
316056001668	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
316056001669	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
316056001670	HSP70 interaction site [polypeptide binding]; other site
316056001671	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
316056001672	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
316056001673	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
316056001674	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
316056001675	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
316056001676	Domain of unknown function DUF29; Region: DUF29; pfam01724
316056001677	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
316056001678	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
316056001679	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
316056001680	metal ion-dependent adhesion site (MIDAS); other site
316056001681	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
316056001682	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
316056001683	HAMP domain; Region: HAMP; pfam00672
316056001684	PAS fold; Region: PAS_4; pfam08448
316056001685	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
316056001686	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056001687	putative active site [active]
316056001688	heme pocket [chemical binding]; other site
316056001689	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056001690	dimer interface [polypeptide binding]; other site
316056001691	phosphorylation site [posttranslational modification]
316056001692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056001693	ATP binding site [chemical binding]; other site
316056001694	G-X-G motif; other site
316056001695	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
316056001696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056001697	active site
316056001698	phosphorylation site [posttranslational modification]
316056001699	intermolecular recognition site; other site
316056001700	dimerization interface [polypeptide binding]; other site
316056001701	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
316056001702	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
316056001703	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
316056001704	DEAD/DEAH box helicase; Region: DEAD; pfam00270
316056001705	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316056001706	nucleotide binding region [chemical binding]; other site
316056001707	ATP-binding site [chemical binding]; other site
316056001708	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
316056001709	RNA binding surface [nucleotide binding]; other site
316056001710	Ferredoxin [Energy production and conversion]; Region: COG1146
316056001711	4Fe-4S binding domain; Region: Fer4; pfam00037
316056001712	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
316056001713	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
316056001714	NIPSNAP; Region: NIPSNAP; pfam07978
316056001715	NIPSNAP; Region: NIPSNAP; pfam07978
316056001716	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
316056001717	Peptidase family M48; Region: Peptidase_M48; pfam01435
316056001718	Staphylococcal nuclease homologues; Region: SNc; smart00318
316056001719	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
316056001720	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
316056001721	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056001722	substrate binding site [chemical binding]; other site
316056001723	oxyanion hole (OAH) forming residues; other site
316056001724	trimer interface [polypeptide binding]; other site
316056001725	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056001726	NAD(P) binding site [chemical binding]; other site
316056001727	active site
316056001728	Predicted membrane protein [Function unknown]; Region: COG2261
316056001729	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
316056001730	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
316056001731	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
316056001732	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
316056001733	Cytochrome c; Region: Cytochrom_C; pfam00034
316056001734	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
316056001735	putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056
316056001736	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
316056001737	PAS fold; Region: PAS_3; pfam08447
316056001738	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
316056001739	PAS domain S-box; Region: sensory_box; TIGR00229
316056001740	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056001741	putative active site [active]
316056001742	heme pocket [chemical binding]; other site
316056001743	PAS fold; Region: PAS_4; pfam08448
316056001744	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056001745	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056001746	dimer interface [polypeptide binding]; other site
316056001747	phosphorylation site [posttranslational modification]
316056001748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056001749	ATP binding site [chemical binding]; other site
316056001750	Mg2+ binding site [ion binding]; other site
316056001751	G-X-G motif; other site
316056001752	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
316056001753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056001754	active site
316056001755	phosphorylation site [posttranslational modification]
316056001756	intermolecular recognition site; other site
316056001757	dimerization interface [polypeptide binding]; other site
316056001758	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
316056001759	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056001760	acyl-activating enzyme (AAE) consensus motif; other site
316056001761	AMP binding site [chemical binding]; other site
316056001762	active site
316056001763	CoA binding site [chemical binding]; other site
316056001764	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
316056001765	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
316056001766	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
316056001767	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
316056001768	Walker A/P-loop; other site
316056001769	ATP binding site [chemical binding]; other site
316056001770	Q-loop/lid; other site
316056001771	ABC transporter signature motif; other site
316056001772	Walker B; other site
316056001773	D-loop; other site
316056001774	H-loop/switch region; other site
316056001775	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316056001776	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
316056001777	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056001778	dimer interface [polypeptide binding]; other site
316056001779	conserved gate region; other site
316056001780	ABC-ATPase subunit interface; other site
316056001781	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
316056001782	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
316056001783	ATP-grasp domain; Region: ATP-grasp_4; cl17255
316056001784	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
316056001785	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
316056001786	active site
316056001787	FMN binding site [chemical binding]; other site
316056001788	substrate binding site [chemical binding]; other site
316056001789	3Fe-4S cluster binding site [ion binding]; other site
316056001790	Creatinine amidohydrolase; Region: Creatininase; pfam02633
316056001791	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
316056001792	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
316056001793	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
316056001794	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
316056001795	Walker A/P-loop; other site
316056001796	ATP binding site [chemical binding]; other site
316056001797	Q-loop/lid; other site
316056001798	ABC transporter signature motif; other site
316056001799	Walker B; other site
316056001800	D-loop; other site
316056001801	H-loop/switch region; other site
316056001802	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
316056001803	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
316056001804	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
316056001805	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
316056001806	putative ligand binding site [chemical binding]; other site
316056001807	NAD binding site [chemical binding]; other site
316056001808	catalytic site [active]
316056001809	hypothetical protein; Reviewed; Region: PRK00024
316056001810	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
316056001811	MPN+ (JAMM) motif; other site
316056001812	Zinc-binding site [ion binding]; other site
316056001813	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
316056001814	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
316056001815	putative DNA binding site [nucleotide binding]; other site
316056001816	putative homodimer interface [polypeptide binding]; other site
316056001817	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
316056001818	active site
316056001819	Mechanosensitive ion channel; Region: MS_channel; pfam00924
316056001820	potassium/proton antiporter; Reviewed; Region: PRK05326
316056001821	Transporter associated domain; Region: CorC_HlyC; smart01091
316056001822	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
316056001823	PAS domain; Region: PAS; smart00091
316056001824	PAS fold; Region: PAS_7; pfam12860
316056001825	PAS domain S-box; Region: sensory_box; TIGR00229
316056001826	PAS domain; Region: PAS; smart00091
316056001827	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056001828	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056001829	metal binding site [ion binding]; metal-binding site
316056001830	active site
316056001831	I-site; other site
316056001832	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056001833	Secretory lipase; Region: LIP; pfam03583
316056001834	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
316056001835	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
316056001836	PemK-like protein; Region: PemK; pfam02452
316056001837	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
316056001838	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
316056001839	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
316056001840	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
316056001841	GTP-binding protein LepA; Provisional; Region: PRK05433
316056001842	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
316056001843	G1 box; other site
316056001844	putative GEF interaction site [polypeptide binding]; other site
316056001845	GTP/Mg2+ binding site [chemical binding]; other site
316056001846	Switch I region; other site
316056001847	G2 box; other site
316056001848	G3 box; other site
316056001849	Switch II region; other site
316056001850	G4 box; other site
316056001851	G5 box; other site
316056001852	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
316056001853	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
316056001854	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
316056001855	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
316056001856	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
316056001857	dimerization domain swap beta strand [polypeptide binding]; other site
316056001858	regulatory protein interface [polypeptide binding]; other site
316056001859	active site
316056001860	regulatory phosphorylation site [posttranslational modification]; other site
316056001861	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
316056001862	active pocket/dimerization site; other site
316056001863	active site
316056001864	phosphorylation site [posttranslational modification]
316056001865	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
316056001866	Hpr binding site; other site
316056001867	active site
316056001868	homohexamer subunit interaction site [polypeptide binding]; other site
316056001869	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
316056001870	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
316056001871	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056001872	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056001873	dimer interface [polypeptide binding]; other site
316056001874	phosphorylation site [posttranslational modification]
316056001875	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056001876	ATP binding site [chemical binding]; other site
316056001877	Mg2+ binding site [ion binding]; other site
316056001878	G-X-G motif; other site
316056001879	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316056001880	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056001881	active site
316056001882	phosphorylation site [posttranslational modification]
316056001883	intermolecular recognition site; other site
316056001884	dimerization interface [polypeptide binding]; other site
316056001885	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056001886	DNA binding site [nucleotide binding]
316056001887	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
316056001888	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
316056001889	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
316056001890	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
316056001891	active site
316056001892	substrate-binding site [chemical binding]; other site
316056001893	metal-binding site [ion binding]
316056001894	ATP binding site [chemical binding]; other site
316056001895	Integrase core domain; Region: rve; pfam00665
316056001896	transposase; Validated; Region: PRK08181
316056001897	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056001898	Walker A motif; other site
316056001899	ATP binding site [chemical binding]; other site
316056001900	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
316056001901	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
316056001902	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316056001903	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316056001904	DNA binding residues [nucleotide binding]
316056001905	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
316056001906	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
316056001907	RNA binding surface [nucleotide binding]; other site
316056001908	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
316056001909	active site
316056001910	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
316056001911	FOG: CBS domain [General function prediction only]; Region: COG0517
316056001912	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
316056001913	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
316056001914	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
316056001915	ligand binding site; other site
316056001916	oligomer interface; other site
316056001917	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
316056001918	dimer interface [polypeptide binding]; other site
316056001919	N-terminal domain interface [polypeptide binding]; other site
316056001920	sulfate 1 binding site; other site
316056001921	glycogen synthase; Provisional; Region: PRK14099
316056001922	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
316056001923	ADP-binding pocket [chemical binding]; other site
316056001924	homodimer interface [polypeptide binding]; other site
316056001925	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
316056001926	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
316056001927	active site
316056001928	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
316056001929	putative active site [active]
316056001930	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
316056001931	HWE histidine kinase; Region: HWE_HK; smart00911
316056001932	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
316056001933	arsenical-resistance protein; Region: acr3; TIGR00832
316056001934	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
316056001935	ArsC family; Region: ArsC; pfam03960
316056001936	catalytic residues [active]
316056001937	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
316056001938	Low molecular weight phosphatase family; Region: LMWPc; cd00115
316056001939	active site
316056001940	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316056001941	dimerization interface [polypeptide binding]; other site
316056001942	putative DNA binding site [nucleotide binding]; other site
316056001943	putative Zn2+ binding site [ion binding]; other site
316056001944	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
316056001945	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
316056001946	catalytic residues [active]
316056001947	LrgB-like family; Region: LrgB; pfam04172
316056001948	LrgA family; Region: LrgA; pfam03788
316056001949	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
316056001950	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
316056001951	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
316056001952	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
316056001953	integrase; Provisional; Region: PRK09692
316056001954	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
316056001955	active site
316056001956	Int/Topo IB signature motif; other site
316056001957	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
316056001958	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056001959	substrate binding site [chemical binding]; other site
316056001960	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
316056001961	oxyanion hole (OAH) forming residues; other site
316056001962	trimer interface [polypeptide binding]; other site
316056001963	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
316056001964	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056001965	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056001966	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
316056001967	dimerization interface [polypeptide binding]; other site
316056001968	substrate binding pocket [chemical binding]; other site
316056001969	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
316056001970	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
316056001971	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
316056001972	dimer interface [polypeptide binding]; other site
316056001973	active site
316056001974	Coenzyme A transferase; Region: CoA_trans; cl17247
316056001975	Coenzyme A transferase; Region: CoA_trans; cl17247
316056001976	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056001977	putative substrate translocation pore; other site
316056001978	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
316056001979	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056001980	putative substrate translocation pore; other site
316056001981	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316056001982	putative acyltransferase; Provisional; Region: PRK05790
316056001983	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
316056001984	dimer interface [polypeptide binding]; other site
316056001985	active site
316056001986	propionate/acetate kinase; Provisional; Region: PRK12379
316056001987	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
316056001988	phosphate acetyltransferase; Reviewed; Region: PRK05632
316056001989	DRTGG domain; Region: DRTGG; pfam07085
316056001990	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
316056001991	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
316056001992	classical (c) SDRs; Region: SDR_c; cd05233
316056001993	NAD(P) binding site [chemical binding]; other site
316056001994	active site
316056001995	epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247
316056001996	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
316056001997	FOG: CBS domain [General function prediction only]; Region: COG0517
316056001998	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
316056001999	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
316056002000	Transposase; Region: HTH_Tnp_1; pfam01527
316056002001	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
316056002002	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
316056002003	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
316056002004	TrwC relaxase; Region: TrwC; pfam08751
316056002005	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
316056002006	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
316056002007	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
316056002008	Walker A motif; other site
316056002009	ATP binding site [chemical binding]; other site
316056002010	Walker B motif; other site
316056002011	HAMP domain; Region: HAMP; pfam00672
316056002012	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056002013	dimer interface [polypeptide binding]; other site
316056002014	phosphorylation site [posttranslational modification]
316056002015	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056002016	ATP binding site [chemical binding]; other site
316056002017	Mg2+ binding site [ion binding]; other site
316056002018	G-X-G motif; other site
316056002019	Response regulator receiver domain; Region: Response_reg; pfam00072
316056002020	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056002021	active site
316056002022	phosphorylation site [posttranslational modification]
316056002023	intermolecular recognition site; other site
316056002024	dimerization interface [polypeptide binding]; other site
316056002025	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
316056002026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056002027	active site
316056002028	phosphorylation site [posttranslational modification]
316056002029	intermolecular recognition site; other site
316056002030	dimerization interface [polypeptide binding]; other site
316056002031	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056002032	DNA binding site [nucleotide binding]
316056002033	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
316056002034	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
316056002035	Dihaem cytochrome c; Region: DHC; pfam09626
316056002036	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
316056002037	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
316056002038	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
316056002039	molybdopterin cofactor binding site [chemical binding]; other site
316056002040	substrate binding site [chemical binding]; other site
316056002041	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
316056002042	molybdopterin cofactor binding site; other site
316056002043	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
316056002044	Flavodoxin; Region: Flavodoxin_1; pfam00258
316056002045	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
316056002046	ApbE family; Region: ApbE; pfam02424
316056002047	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
316056002048	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
316056002049	molybdopterin cofactor binding site; other site
316056002050	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
316056002051	molybdopterin cofactor binding site; other site
316056002052	Proline dehydrogenase; Region: Pro_dh; cl03282
316056002053	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
316056002054	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
316056002055	O-Antigen ligase; Region: Wzy_C; pfam04932
316056002056	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
316056002057	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
316056002058	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
316056002059	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
316056002060	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
316056002061	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
316056002062	active site
316056002063	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
316056002064	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
316056002065	active site
316056002066	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
316056002067	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
316056002068	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
316056002069	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
316056002070	putative active site [active]
316056002071	putative metal binding site [ion binding]; other site
316056002072	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
316056002073	Chain length determinant protein; Region: Wzz; pfam02706
316056002074	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
316056002075	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
316056002076	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
316056002077	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
316056002078	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316056002079	Walker A/P-loop; other site
316056002080	ATP binding site [chemical binding]; other site
316056002081	Q-loop/lid; other site
316056002082	ABC transporter signature motif; other site
316056002083	Walker B; other site
316056002084	D-loop; other site
316056002085	H-loop/switch region; other site
316056002086	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
316056002087	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316056002088	Walker A/P-loop; other site
316056002089	ATP binding site [chemical binding]; other site
316056002090	Q-loop/lid; other site
316056002091	ABC transporter signature motif; other site
316056002092	Walker B; other site
316056002093	D-loop; other site
316056002094	H-loop/switch region; other site
316056002095	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
316056002096	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316056002097	TM-ABC transporter signature motif; other site
316056002098	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316056002099	TM-ABC transporter signature motif; other site
316056002100	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
316056002101	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
316056002102	putative ligand binding site [chemical binding]; other site
316056002103	enoyl-CoA hydratase; Provisional; Region: PRK08140
316056002104	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056002105	substrate binding site [chemical binding]; other site
316056002106	oxyanion hole (OAH) forming residues; other site
316056002107	trimer interface [polypeptide binding]; other site
316056002108	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
316056002109	CoenzymeA binding site [chemical binding]; other site
316056002110	subunit interaction site [polypeptide binding]; other site
316056002111	PHB binding site; other site
316056002112	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056002113	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
316056002114	acyl-activating enzyme (AAE) consensus motif; other site
316056002115	AMP binding site [chemical binding]; other site
316056002116	active site
316056002117	CoA binding site [chemical binding]; other site
316056002118	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056002119	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056002120	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
316056002121	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
316056002122	substrate binding site [chemical binding]; other site
316056002123	dimer interface [polypeptide binding]; other site
316056002124	NADP binding site [chemical binding]; other site
316056002125	catalytic residues [active]
316056002126	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
316056002127	active site 2 [active]
316056002128	active site 1 [active]
316056002129	EthD domain; Region: EthD; cl17553
316056002130	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
316056002131	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
316056002132	FAD binding pocket [chemical binding]; other site
316056002133	FAD binding motif [chemical binding]; other site
316056002134	phosphate binding motif [ion binding]; other site
316056002135	beta-alpha-beta structure motif; other site
316056002136	NAD(p) ribose binding residues [chemical binding]; other site
316056002137	NAD binding pocket [chemical binding]; other site
316056002138	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
316056002139	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316056002140	catalytic loop [active]
316056002141	iron binding site [ion binding]; other site
316056002142	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
316056002143	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
316056002144	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
316056002145	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
316056002146	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
316056002147	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
316056002148	PaaX-like protein; Region: PaaX; pfam07848
316056002149	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
316056002150	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
316056002151	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
316056002152	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
316056002153	dimer interface [polypeptide binding]; other site
316056002154	PYR/PP interface [polypeptide binding]; other site
316056002155	TPP binding site [chemical binding]; other site
316056002156	substrate binding site [chemical binding]; other site
316056002157	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
316056002158	TPP-binding site; other site
316056002159	4Fe-4S binding domain; Region: Fer4; pfam00037
316056002160	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
316056002161	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
316056002162	Ferredoxin [Energy production and conversion]; Region: COG1146
316056002163	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
316056002164	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
316056002165	dimer interface [polypeptide binding]; other site
316056002166	PYR/PP interface [polypeptide binding]; other site
316056002167	TPP binding site [chemical binding]; other site
316056002168	substrate binding site [chemical binding]; other site
316056002169	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
316056002170	2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628
316056002171	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
316056002172	TPP-binding site [chemical binding]; other site
316056002173	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
316056002174	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056002175	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
316056002176	acyl-activating enzyme (AAE) consensus motif; other site
316056002177	AMP binding site [chemical binding]; other site
316056002178	active site
316056002179	CoA binding site [chemical binding]; other site
316056002180	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
316056002181	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
316056002182	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056002183	catalytic residue [active]
316056002184	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
316056002185	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
316056002186	putative substrate binding site [chemical binding]; other site
316056002187	putative ATP binding site [chemical binding]; other site
316056002188	Autoinducer synthetase; Region: Autoind_synth; cl17404
316056002189	Autoinducer binding domain; Region: Autoind_bind; pfam03472
316056002190	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316056002191	DNA binding residues [nucleotide binding]
316056002192	dimerization interface [polypeptide binding]; other site
316056002193	putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Provisional; Region: PRK12779
316056002194	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
316056002195	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
316056002196	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
316056002197	FAD binding pocket [chemical binding]; other site
316056002198	FAD binding motif [chemical binding]; other site
316056002199	phosphate binding motif [ion binding]; other site
316056002200	beta-alpha-beta structure motif; other site
316056002201	NAD binding pocket [chemical binding]; other site
316056002202	Iron coordination center [ion binding]; other site
316056002203	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674
316056002204	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
316056002205	dimer interface [polypeptide binding]; other site
316056002206	PYR/PP interface [polypeptide binding]; other site
316056002207	TPP binding site [chemical binding]; other site
316056002208	substrate binding site [chemical binding]; other site
316056002209	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
316056002210	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
316056002211	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
316056002212	4Fe-4S binding domain; Region: Fer4_6; pfam12837
316056002213	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
316056002214	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
316056002215	Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018
316056002216	dimer interface [polypeptide binding]; other site
316056002217	TPP-binding site [chemical binding]; other site
316056002218	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
316056002219	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
316056002220	molybdenum-pterin binding domain; Region: Mop; TIGR00638
316056002221	TOBE domain; Region: TOBE; cl01440
316056002222	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
316056002223	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
316056002224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056002225	dimer interface [polypeptide binding]; other site
316056002226	conserved gate region; other site
316056002227	putative PBP binding loops; other site
316056002228	ABC-ATPase subunit interface; other site
316056002229	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
316056002230	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056002231	Walker A/P-loop; other site
316056002232	ATP binding site [chemical binding]; other site
316056002233	Q-loop/lid; other site
316056002234	ABC transporter signature motif; other site
316056002235	Walker B; other site
316056002236	D-loop; other site
316056002237	H-loop/switch region; other site
316056002238	TOBE domain; Region: TOBE; cl01440
316056002239	Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476
316056002240	putative active site [active]
316056002241	putative catalytic triad [active]
316056002242	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
316056002243	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
316056002244	active site 2 [active]
316056002245	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
316056002246	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
316056002247	FMN binding site [chemical binding]; other site
316056002248	substrate binding site [chemical binding]; other site
316056002249	putative catalytic residue [active]
316056002250	Predicted membrane protein [Function unknown]; Region: COG1238
316056002251	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
316056002252	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
316056002253	metal binding site [ion binding]; metal-binding site
316056002254	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
316056002255	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316056002256	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056002257	Walker A/P-loop; other site
316056002258	ATP binding site [chemical binding]; other site
316056002259	Q-loop/lid; other site
316056002260	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316056002261	ABC transporter signature motif; other site
316056002262	Walker B; other site
316056002263	D-loop; other site
316056002264	ABC transporter; Region: ABC_tran_2; pfam12848
316056002265	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316056002266	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
316056002267	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
316056002268	Cu(I) binding site [ion binding]; other site
316056002269	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
316056002270	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
316056002271	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
316056002272	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
316056002273	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316056002274	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
316056002275	substrate binding pocket [chemical binding]; other site
316056002276	membrane-bound complex binding site; other site
316056002277	hinge residues; other site
316056002278	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
316056002279	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
316056002280	active site
316056002281	nucleotide binding site [chemical binding]; other site
316056002282	HIGH motif; other site
316056002283	KMSKS motif; other site
316056002284	PAN domain; Region: PAN_4; pfam14295
316056002285	glutamate--cysteine ligase; Region: PLN02611
316056002286	MarR family; Region: MarR_2; pfam12802
316056002287	Transcriptional regulators [Transcription]; Region: MarR; COG1846
316056002288	glutathionine S-transferase; Provisional; Region: PRK10542
316056002289	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
316056002290	C-terminal domain interface [polypeptide binding]; other site
316056002291	GSH binding site (G-site) [chemical binding]; other site
316056002292	dimer interface [polypeptide binding]; other site
316056002293	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
316056002294	dimer interface [polypeptide binding]; other site
316056002295	N-terminal domain interface [polypeptide binding]; other site
316056002296	substrate binding pocket (H-site) [chemical binding]; other site
316056002297	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
316056002298	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056002299	substrate binding site [chemical binding]; other site
316056002300	oxyanion hole (OAH) forming residues; other site
316056002301	trimer interface [polypeptide binding]; other site
316056002302	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
316056002303	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
316056002304	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
316056002305	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
316056002306	dimer interface [polypeptide binding]; other site
316056002307	active site
316056002308	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
316056002309	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
316056002310	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
316056002311	FAD binding site [chemical binding]; other site
316056002312	substrate binding site [chemical binding]; other site
316056002313	catalytic residues [active]
316056002314	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
316056002315	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
316056002316	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056002317	binding surface
316056002318	TPR motif; other site
316056002319	Sel1-like repeats; Region: SEL1; smart00671
316056002320	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056002321	S-adenosylmethionine binding site [chemical binding]; other site
316056002322	Cupin domain; Region: Cupin_2; cl17218
316056002323	Helix-turn-helix domain; Region: HTH_18; pfam12833
316056002324	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316056002325	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
316056002326	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
316056002327	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
316056002328	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
316056002329	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
316056002330	EamA-like transporter family; Region: EamA; pfam00892
316056002331	EamA-like transporter family; Region: EamA; pfam00892
316056002332	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056002333	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056002334	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316056002335	dimerization interface [polypeptide binding]; other site
316056002336	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
316056002337	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
316056002338	putative active site [active]
316056002339	putative metal binding site [ion binding]; other site
316056002340	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316056002341	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
316056002342	putative Mg++ binding site [ion binding]; other site
316056002343	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316056002344	nucleotide binding region [chemical binding]; other site
316056002345	ATP-binding site [chemical binding]; other site
316056002346	DEAD/H associated; Region: DEAD_assoc; pfam08494
316056002347	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
316056002348	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
316056002349	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
316056002350	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056002351	TPR motif; other site
316056002352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056002353	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
316056002354	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
316056002355	ATP-dependent DNA ligase; Validated; Region: PRK09247
316056002356	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
316056002357	active site
316056002358	DNA binding site [nucleotide binding]
316056002359	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
316056002360	DNA binding site [nucleotide binding]
316056002361	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
316056002362	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
316056002363	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
316056002364	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
316056002365	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
316056002366	quinone interaction residues [chemical binding]; other site
316056002367	active site
316056002368	catalytic residues [active]
316056002369	FMN binding site [chemical binding]; other site
316056002370	substrate binding site [chemical binding]; other site
316056002371	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
316056002372	Predicted transcriptional regulator [Transcription]; Region: COG2932
316056002373	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
316056002374	Catalytic site [active]
316056002375	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
316056002376	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
316056002377	active site
316056002378	zinc binding site [ion binding]; other site
316056002379	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
316056002380	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
316056002381	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
316056002382	active site
316056002383	dimer interface [polypeptide binding]; other site
316056002384	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
316056002385	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
316056002386	active site
316056002387	FMN binding site [chemical binding]; other site
316056002388	substrate binding site [chemical binding]; other site
316056002389	3Fe-4S cluster binding site [ion binding]; other site
316056002390	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
316056002391	domain interface; other site
316056002392	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
316056002393	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
316056002394	putative dimer interface [polypeptide binding]; other site
316056002395	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
316056002396	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
316056002397	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
316056002398	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
316056002399	active site
316056002400	tetramer interface; other site
316056002401	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056002402	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056002403	metal binding site [ion binding]; metal-binding site
316056002404	active site
316056002405	I-site; other site
316056002406	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
316056002407	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
316056002408	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
316056002409	putative active site [active]
316056002410	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
316056002411	muropeptide transporter; Validated; Region: ampG; cl17669
316056002412	muropeptide transporter; Reviewed; Region: ampG; PRK11902
316056002413	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
316056002414	active site
316056002415	oxyanion hole [active]
316056002416	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
316056002417	catalytic triad [active]
316056002418	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
316056002419	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
316056002420	active site
316056002421	DNA binding site [nucleotide binding]
316056002422	Int/Topo IB signature motif; other site
316056002423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056002424	Methyltransferase domain; Region: Methyltransf_31; pfam13847
316056002425	S-adenosylmethionine binding site [chemical binding]; other site
316056002426	Transglycosylase SLT domain; Region: SLT_2; pfam13406
316056002427	murein hydrolase B; Provisional; Region: PRK10760; cl17906
316056002428	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
316056002429	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
316056002430	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056002431	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056002432	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316056002433	dimerization interface [polypeptide binding]; other site
316056002434	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
316056002435	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
316056002436	active site
316056002437	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
316056002438	Response regulator receiver domain; Region: Response_reg; pfam00072
316056002439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056002440	active site
316056002441	phosphorylation site [posttranslational modification]
316056002442	intermolecular recognition site; other site
316056002443	dimerization interface [polypeptide binding]; other site
316056002444	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
316056002445	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
316056002446	Pirin-related protein [General function prediction only]; Region: COG1741
316056002447	Pirin; Region: Pirin; pfam02678
316056002448	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056002449	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056002450	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
316056002451	putative effector binding pocket; other site
316056002452	dimerization interface [polypeptide binding]; other site
316056002453	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
316056002454	hypothetical protein; Validated; Region: PRK00228
316056002455	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
316056002456	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
316056002457	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
316056002458	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056002459	PAS fold; Region: PAS_3; pfam08447
316056002460	putative active site [active]
316056002461	heme pocket [chemical binding]; other site
316056002462	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056002463	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056002464	metal binding site [ion binding]; metal-binding site
316056002465	active site
316056002466	I-site; other site
316056002467	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056002468	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
316056002469	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
316056002470	NAD(P) binding site [chemical binding]; other site
316056002471	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
316056002472	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
316056002473	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
316056002474	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056002475	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056002476	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056002477	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056002478	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
316056002479	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
316056002480	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316056002481	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056002482	Walker A/P-loop; other site
316056002483	ATP binding site [chemical binding]; other site
316056002484	Q-loop/lid; other site
316056002485	ABC transporter signature motif; other site
316056002486	Walker B; other site
316056002487	D-loop; other site
316056002488	H-loop/switch region; other site
316056002489	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
316056002490	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056002491	Coenzyme A binding pocket [chemical binding]; other site
316056002492	hypothetical protein; Validated; Region: PRK09039
316056002493	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
316056002494	ligand binding site [chemical binding]; other site
316056002495	RmuC family; Region: RmuC; pfam02646
316056002496	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
316056002497	active site
316056002498	catalytic residues [active]
316056002499	metal binding site [ion binding]; metal-binding site
316056002500	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
316056002501	oligomeric interface; other site
316056002502	putative active site [active]
316056002503	homodimer interface [polypeptide binding]; other site
316056002504	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
316056002505	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
316056002506	putative active site [active]
316056002507	substrate binding site [chemical binding]; other site
316056002508	putative cosubstrate binding site; other site
316056002509	catalytic site [active]
316056002510	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
316056002511	substrate binding site [chemical binding]; other site
316056002512	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
316056002513	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
316056002514	dimerization interface 3.5A [polypeptide binding]; other site
316056002515	active site
316056002516	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
316056002517	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
316056002518	metal binding site [ion binding]; metal-binding site
316056002519	dimer interface [polypeptide binding]; other site
316056002520	Predicted membrane protein [Function unknown]; Region: COG3152
316056002521	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
316056002522	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
316056002523	trimer interface [polypeptide binding]; other site
316056002524	active site
316056002525	substrate binding site [chemical binding]; other site
316056002526	CoA binding site [chemical binding]; other site
316056002527	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
316056002528	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316056002529	motif II; other site
316056002530	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
316056002531	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
316056002532	Protein of unknown function (DUF1036); Region: DUF1036; pfam06282
316056002533	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
316056002534	feedback inhibition sensing region; other site
316056002535	homohexameric interface [polypeptide binding]; other site
316056002536	nucleotide binding site [chemical binding]; other site
316056002537	N-acetyl-L-glutamate binding site [chemical binding]; other site
316056002538	Protein of unknown function (DUF423); Region: DUF423; pfam04241
316056002539	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
316056002540	G1 box; other site
316056002541	GTP/Mg2+ binding site [chemical binding]; other site
316056002542	Switch I region; other site
316056002543	G2 box; other site
316056002544	G3 box; other site
316056002545	Switch II region; other site
316056002546	G4 box; other site
316056002547	G5 box; other site
316056002548	membrane protein insertase; Provisional; Region: PRK01318
316056002549	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
316056002550	Ribonuclease P; Region: Ribonuclease_P; cl00457
316056002551	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
316056002552	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056002553	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056002554	ATP binding site [chemical binding]; other site
316056002555	Mg2+ binding site [ion binding]; other site
316056002556	G-X-G motif; other site
316056002557	PemK-like protein; Region: PemK; pfam02452
316056002558	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
316056002559	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
316056002560	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
316056002561	Citrate transporter; Region: CitMHS; pfam03600
316056002562	acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361
316056002563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056002564	active site
316056002565	phosphorylation site [posttranslational modification]
316056002566	intermolecular recognition site; other site
316056002567	dimerization interface [polypeptide binding]; other site
316056002568	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056002569	Walker A motif; other site
316056002570	ATP binding site [chemical binding]; other site
316056002571	Walker B motif; other site
316056002572	arginine finger; other site
316056002573	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316056002574	sensory histidine kinase AtoS; Provisional; Region: PRK11360
316056002575	HAMP domain; Region: HAMP; pfam00672
316056002576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056002577	putative active site [active]
316056002578	heme pocket [chemical binding]; other site
316056002579	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056002580	dimer interface [polypeptide binding]; other site
316056002581	phosphorylation site [posttranslational modification]
316056002582	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056002583	ATP binding site [chemical binding]; other site
316056002584	Mg2+ binding site [ion binding]; other site
316056002585	G-X-G motif; other site
316056002586	Coenzyme A transferase; Region: CoA_trans; cl17247
316056002587	Coenzyme A transferase; Region: CoA_trans; cl17247
316056002588	Short chain fatty acid transporter; Region: SCFA_trans; cl17380
316056002589	putative acyltransferase; Provisional; Region: PRK05790
316056002590	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
316056002591	dimer interface [polypeptide binding]; other site
316056002592	active site
316056002593	Acetokinase family; Region: Acetate_kinase; cl17229
316056002594	propionate/acetate kinase; Provisional; Region: PRK12379
316056002595	phosphate acetyltransferase; Reviewed; Region: PRK05632
316056002596	DRTGG domain; Region: DRTGG; pfam07085
316056002597	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
316056002598	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056002599	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056002600	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
316056002601	putative dimerization interface [polypeptide binding]; other site
316056002602	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
316056002603	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
316056002604	putative ligand binding site [chemical binding]; other site
316056002605	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316056002606	TM-ABC transporter signature motif; other site
316056002607	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
316056002608	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316056002609	TM-ABC transporter signature motif; other site
316056002610	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
316056002611	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316056002612	Walker A/P-loop; other site
316056002613	ATP binding site [chemical binding]; other site
316056002614	Q-loop/lid; other site
316056002615	ABC transporter signature motif; other site
316056002616	Walker B; other site
316056002617	D-loop; other site
316056002618	H-loop/switch region; other site
316056002619	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
316056002620	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316056002621	Walker A/P-loop; other site
316056002622	ATP binding site [chemical binding]; other site
316056002623	Q-loop/lid; other site
316056002624	ABC transporter signature motif; other site
316056002625	Walker B; other site
316056002626	D-loop; other site
316056002627	H-loop/switch region; other site
316056002628	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056002629	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056002630	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
316056002631	dimerization interface [polypeptide binding]; other site
316056002632	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
316056002633	Flavoprotein; Region: Flavoprotein; pfam02441
316056002634	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
316056002635	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
316056002636	NMT1-like family; Region: NMT1_2; pfam13379
316056002637	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
316056002638	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
316056002639	Walker A/P-loop; other site
316056002640	ATP binding site [chemical binding]; other site
316056002641	Q-loop/lid; other site
316056002642	ABC transporter signature motif; other site
316056002643	Walker B; other site
316056002644	D-loop; other site
316056002645	H-loop/switch region; other site
316056002646	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
316056002647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056002648	dimer interface [polypeptide binding]; other site
316056002649	conserved gate region; other site
316056002650	putative PBP binding loops; other site
316056002651	ABC-ATPase subunit interface; other site
316056002652	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
316056002653	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
316056002654	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316056002655	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
316056002656	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
316056002657	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
316056002658	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
316056002659	putative hydrophobic ligand binding site [chemical binding]; other site
316056002660	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
316056002661	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
316056002662	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
316056002663	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316056002664	catalytic loop [active]
316056002665	iron binding site [ion binding]; other site
316056002666	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
316056002667	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
316056002668	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056002669	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
316056002670	acyl-activating enzyme (AAE) consensus motif; other site
316056002671	acyl-activating enzyme (AAE) consensus motif; other site
316056002672	putative AMP binding site [chemical binding]; other site
316056002673	putative active site [active]
316056002674	putative CoA binding site [chemical binding]; other site
316056002675	enoyl-CoA hydratase; Provisional; Region: PRK06688
316056002676	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056002677	substrate binding site [chemical binding]; other site
316056002678	oxyanion hole (OAH) forming residues; other site
316056002679	trimer interface [polypeptide binding]; other site
316056002680	Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Region: ALDH_PsfA-ACA09737; cd07120
316056002681	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
316056002682	NAD(P) binding site [chemical binding]; other site
316056002683	catalytic residues [active]
316056002684	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056002685	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056002686	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
316056002687	putative effector binding pocket; other site
316056002688	dimerization interface [polypeptide binding]; other site
316056002689	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316056002690	membrane-bound complex binding site; other site
316056002691	hinge residues; other site
316056002692	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
316056002693	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056002694	dimer interface [polypeptide binding]; other site
316056002695	conserved gate region; other site
316056002696	putative PBP binding loops; other site
316056002697	ABC-ATPase subunit interface; other site
316056002698	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
316056002699	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
316056002700	Walker A/P-loop; other site
316056002701	ATP binding site [chemical binding]; other site
316056002702	Q-loop/lid; other site
316056002703	ABC transporter signature motif; other site
316056002704	Walker B; other site
316056002705	D-loop; other site
316056002706	H-loop/switch region; other site
316056002707	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
316056002708	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056002709	substrate binding site [chemical binding]; other site
316056002710	oxyanion hole (OAH) forming residues; other site
316056002711	trimer interface [polypeptide binding]; other site
316056002712	lipid-transfer protein; Provisional; Region: PRK07855
316056002713	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
316056002714	active site
316056002715	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
316056002716	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
316056002717	DUF35 OB-fold domain; Region: DUF35; pfam01796
316056002718	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
316056002719	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056002720	acyl-activating enzyme (AAE) consensus motif; other site
316056002721	AMP binding site [chemical binding]; other site
316056002722	active site
316056002723	CoA binding site [chemical binding]; other site
316056002724	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14268
316056002725	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
316056002726	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316056002727	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316056002728	DNA binding residues [nucleotide binding]
316056002729	flagellin; Provisional; Region: PRK12804
316056002730	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
316056002731	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
316056002732	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
316056002733	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
316056002734	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
316056002735	Flagellar protein FliS; Region: FliS; cl00654
316056002736	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
316056002737	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
316056002738	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
316056002739	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
316056002740	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
316056002741	FlgN protein; Region: FlgN; pfam05130
316056002742	Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256
316056002743	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
316056002744	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913
316056002745	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
316056002746	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
316056002747	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
316056002748	ATP binding site [chemical binding]; other site
316056002749	putative Mg++ binding site [ion binding]; other site
316056002750	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316056002751	nucleotide binding region [chemical binding]; other site
316056002752	ATP-binding site [chemical binding]; other site
316056002753	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
316056002754	RNA binding site [nucleotide binding]; other site
316056002755	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
316056002756	Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357
316056002757	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
316056002758	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
316056002759	catalytic triad [active]
316056002760	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
316056002761	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
316056002762	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
316056002763	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
316056002764	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
316056002765	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056002766	FeS/SAM binding site; other site
316056002767	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
316056002768	Nif-specific regulatory protein; Region: nifA; TIGR01817
316056002769	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
316056002770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056002771	Walker A motif; other site
316056002772	ATP binding site [chemical binding]; other site
316056002773	Walker B motif; other site
316056002774	arginine finger; other site
316056002775	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316056002776	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
316056002777	Protein export membrane protein; Region: SecD_SecF; cl14618
316056002778	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056002779	Caspase domain; Region: Peptidase_C14; pfam00656
316056002780	TPR repeat; Region: TPR_11; pfam13414
316056002781	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056002782	binding surface
316056002783	TPR motif; other site
316056002784	TPR repeat; Region: TPR_11; pfam13414
316056002785	TPR repeat; Region: TPR_11; pfam13414
316056002786	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
316056002787	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
316056002788	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
316056002789	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
316056002790	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
316056002791	fumarylacetoacetase; Region: PLN02856
316056002792	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
316056002793	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
316056002794	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
316056002795	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
316056002796	dimer interface [polypeptide binding]; other site
316056002797	motif 1; other site
316056002798	motif 2; other site
316056002799	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
316056002800	active site
316056002801	motif 3; other site
316056002802	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
316056002803	anticodon binding site; other site
316056002804	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
316056002805	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
316056002806	inhibitor-cofactor binding pocket; inhibition site
316056002807	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056002808	catalytic residue [active]
316056002809	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056002810	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
316056002811	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316056002812	active site
316056002813	motif I; other site
316056002814	motif II; other site
316056002815	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316056002816	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
316056002817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056002818	active site
316056002819	phosphorylation site [posttranslational modification]
316056002820	intermolecular recognition site; other site
316056002821	dimerization interface [polypeptide binding]; other site
316056002822	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
316056002823	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
316056002824	DNA-binding site [nucleotide binding]; DNA binding site
316056002825	RNA-binding motif; other site
316056002826	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
316056002827	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
316056002828	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
316056002829	GIY-YIG motif/motif A; other site
316056002830	active site
316056002831	catalytic site [active]
316056002832	putative DNA binding site [nucleotide binding]; other site
316056002833	metal binding site [ion binding]; metal-binding site
316056002834	UvrB/uvrC motif; Region: UVR; pfam02151
316056002835	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
316056002836	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
316056002837	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
316056002838	MoaE interaction surface [polypeptide binding]; other site
316056002839	MoeB interaction surface [polypeptide binding]; other site
316056002840	thiocarboxylated glycine; other site
316056002841	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
316056002842	MoaE homodimer interface [polypeptide binding]; other site
316056002843	MoaD interaction [polypeptide binding]; other site
316056002844	active site residues [active]
316056002845	HemK family putative methylases; Region: hemK_fam; TIGR00536
316056002846	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056002847	S-adenosylmethionine binding site [chemical binding]; other site
316056002848	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
316056002849	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056002850	S-adenosylmethionine binding site [chemical binding]; other site
316056002851	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
316056002852	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
316056002853	RNA binding surface [nucleotide binding]; other site
316056002854	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
316056002855	active site
316056002856	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
316056002857	nucleoside/Zn binding site; other site
316056002858	dimer interface [polypeptide binding]; other site
316056002859	catalytic motif [active]
316056002860	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
316056002861	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
316056002862	CoA-transferase family III; Region: CoA_transf_3; pfam02515
316056002863	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
316056002864	active site 1 [active]
316056002865	dimer interface [polypeptide binding]; other site
316056002866	hexamer interface [polypeptide binding]; other site
316056002867	active site 2 [active]
316056002868	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
316056002869	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
316056002870	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
316056002871	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
316056002872	Protein of unknown function DUF58; Region: DUF58; pfam01882
316056002873	MoxR-like ATPases [General function prediction only]; Region: COG0714
316056002874	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056002875	Walker A motif; other site
316056002876	ATP binding site [chemical binding]; other site
316056002877	Walker B motif; other site
316056002878	arginine finger; other site
316056002879	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
316056002880	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
316056002881	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
316056002882	putative active site [active]
316056002883	putative CoA binding site [chemical binding]; other site
316056002884	nudix motif; other site
316056002885	metal binding site [ion binding]; metal-binding site
316056002886	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
316056002887	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
316056002888	active site
316056002889	NTP binding site [chemical binding]; other site
316056002890	metal binding triad [ion binding]; metal-binding site
316056002891	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
316056002892	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
316056002893	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
316056002894	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
316056002895	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
316056002896	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
316056002897	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
316056002898	[2Fe-2S] cluster binding site [ion binding]; other site
316056002899	cytochrome b; Provisional; Region: CYTB; MTH00191
316056002900	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
316056002901	Qi binding site; other site
316056002902	intrachain domain interface; other site
316056002903	interchain domain interface [polypeptide binding]; other site
316056002904	heme bH binding site [chemical binding]; other site
316056002905	heme bL binding site [chemical binding]; other site
316056002906	Qo binding site; other site
316056002907	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
316056002908	interchain domain interface [polypeptide binding]; other site
316056002909	intrachain domain interface; other site
316056002910	Qi binding site; other site
316056002911	Qo binding site; other site
316056002912	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
316056002913	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
316056002914	hydrogenase 4 subunit B; Validated; Region: PRK06521
316056002915	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056002916	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
316056002917	NADH dehydrogenase; Region: NADHdh; cl00469
316056002918	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
316056002919	hydrogenase 4 subunit F; Validated; Region: PRK06458
316056002920	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056002921	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
316056002922	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
316056002923	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
316056002924	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
316056002925	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
316056002926	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
316056002927	TonB system transport protein ExbD, group 1; Region: ExbD_1; TIGR02803
316056002928	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
316056002929	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
316056002930	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
316056002931	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
316056002932	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
316056002933	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
316056002934	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
316056002935	FliG C-terminal domain; Region: FliG_C; pfam01706
316056002936	flagellar assembly protein H; Validated; Region: fliH; PRK06032
316056002937	Flagellar assembly protein FliH; Region: FliH; pfam02108
316056002938	flagellar motor switch protein; Reviewed; Region: PRK08916
316056002939	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
316056002940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056002941	Walker A motif; other site
316056002942	ATP binding site [chemical binding]; other site
316056002943	Walker B motif; other site
316056002944	arginine finger; other site
316056002945	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316056002946	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
316056002947	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
316056002948	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
316056002949	Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796
316056002950	NapD protein; Region: NapD; pfam03927
316056002951	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
316056002952	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
316056002953	[4Fe-4S] binding site [ion binding]; other site
316056002954	molybdopterin cofactor binding site; other site
316056002955	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
316056002956	molybdopterin cofactor binding site; other site
316056002957	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
316056002958	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
316056002959	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
316056002960	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
316056002961	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056002962	Walker A motif; other site
316056002963	ATP binding site [chemical binding]; other site
316056002964	Part of AAA domain; Region: AAA_19; pfam13245
316056002965	Family description; Region: UvrD_C_2; pfam13538
316056002966	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056002967	S-adenosylmethionine binding site [chemical binding]; other site
316056002968	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
316056002969	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
316056002970	dimerization interface [polypeptide binding]; other site
316056002971	DPS ferroxidase diiron center [ion binding]; other site
316056002972	ion pore; other site
316056002973	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
316056002974	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
316056002975	CoenzymeA binding site [chemical binding]; other site
316056002976	subunit interaction site [polypeptide binding]; other site
316056002977	PHB binding site; other site
316056002978	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
316056002979	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
316056002980	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
316056002981	catalytic site [active]
316056002982	subunit interface [polypeptide binding]; other site
316056002983	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
316056002984	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
316056002985	catalytic site [active]
316056002986	Yqey-like protein; Region: YqeY; pfam09424
316056002987	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
316056002988	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
316056002989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
316056002990	Transposase; Region: DEDD_Tnp_IS110; pfam01548
316056002991	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
316056002992	N-formylglutamate amidohydrolase; Region: FGase; cl01522
316056002993	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
316056002994	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
316056002995	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
316056002996	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
316056002997	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
316056002998	DNA primase, catalytic core; Region: dnaG; TIGR01391
316056002999	CHC2 zinc finger; Region: zf-CHC2; pfam01807
316056003000	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
316056003001	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
316056003002	active site
316056003003	metal binding site [ion binding]; metal-binding site
316056003004	interdomain interaction site; other site
316056003005	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
316056003006	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
316056003007	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
316056003008	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
316056003009	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
316056003010	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316056003011	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
316056003012	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316056003013	DNA binding residues [nucleotide binding]
316056003014	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
316056003015	YcfA-like protein; Region: YcfA; pfam07927
316056003016	Homeodomain-like domain; Region: HTH_23; cl17451
316056003017	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
316056003018	active site
316056003019	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056003020	Coenzyme A binding pocket [chemical binding]; other site
316056003021	Cupin domain; Region: Cupin_2; cl17218
316056003022	hybrid cluster protein; Provisional; Region: PRK05290
316056003023	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
316056003024	ACS interaction site; other site
316056003025	CODH interaction site; other site
316056003026	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
316056003027	hybrid metal cluster; other site
316056003028	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
316056003029	intracellular protease, PfpI family; Region: PfpI; TIGR01382
316056003030	proposed catalytic triad [active]
316056003031	conserved cys residue [active]
316056003032	Transglycosylase SLT domain; Region: SLT_2; pfam13406
316056003033	murein hydrolase B; Provisional; Region: PRK10760; cl17906
316056003034	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316056003035	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316056003036	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
316056003037	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
316056003038	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
316056003039	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
316056003040	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
316056003041	Ligand Binding Site [chemical binding]; other site
316056003042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056003043	S-adenosylmethionine binding site [chemical binding]; other site
316056003044	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
316056003045	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
316056003046	catalytic residues [active]
316056003047	catalytic nucleophile [active]
316056003048	Recombinase; Region: Recombinase; pfam07508
316056003049	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
316056003050	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
316056003051	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
316056003052	MobA/MobL family; Region: MobA_MobL; pfam03389
316056003053	AAA domain; Region: AAA_30; pfam13604
316056003054	Family description; Region: UvrD_C_2; pfam13538
316056003055	Conjugal transfer protein TraD; Region: TraD; pfam06412
316056003056	Conjugal transfer protein TraD; Region: TraD; pfam06412
316056003057	transposase; Validated; Region: PRK08181
316056003058	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056003059	Walker A motif; other site
316056003060	ATP binding site [chemical binding]; other site
316056003061	Integrase core domain; Region: rve; pfam00665
316056003062	AAA domain; Region: AAA_21; pfam13304
316056003063	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056003064	ABC transporter signature motif; other site
316056003065	Walker B; other site
316056003066	D-loop; other site
316056003067	H-loop/switch region; other site
316056003068	Integrase core domain; Region: rve_3; cl15866
316056003069	putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional; Region: PRK12775
316056003070	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
316056003071	FAD binding pocket [chemical binding]; other site
316056003072	FAD binding motif [chemical binding]; other site
316056003073	phosphate binding motif [ion binding]; other site
316056003074	beta-alpha-beta structure motif; other site
316056003075	NAD binding pocket [chemical binding]; other site
316056003076	Iron coordination center [ion binding]; other site
316056003077	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
316056003078	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
316056003079	diiron binding motif [ion binding]; other site
316056003080	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
316056003081	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
316056003082	transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392
316056003083	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056003084	ligand binding site [chemical binding]; other site
316056003085	flexible hinge region; other site
316056003086	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
316056003087	4-hydroxybenzoyl-CoA reductase, beta subunit; Region: 4hydrxCoA_B; TIGR03195
316056003088	FAD binding domain; Region: FAD_binding_4; pfam01565
316056003089	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
316056003090	4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194
316056003091	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
316056003092	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
316056003093	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
316056003094	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111
316056003095	catalytic loop [active]
316056003096	iron binding site [ion binding]; other site
316056003097	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
316056003098	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
316056003099	Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959
316056003100	dimer interface [polypeptide binding]; other site
316056003101	acyl-activating enzyme (AAE) consensus motif; other site
316056003102	putative active site [active]
316056003103	putative AMP binding site [chemical binding]; other site
316056003104	putative CoA binding site [chemical binding]; other site
316056003105	chemical substrate binding site [chemical binding]; other site
316056003106	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
316056003107	Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360
316056003108	putative ligand binding site [chemical binding]; other site
316056003109	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316056003110	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316056003111	TM-ABC transporter signature motif; other site
316056003112	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
316056003113	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316056003114	TM-ABC transporter signature motif; other site
316056003115	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
316056003116	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316056003117	Walker A/P-loop; other site
316056003118	ATP binding site [chemical binding]; other site
316056003119	Q-loop/lid; other site
316056003120	ABC transporter signature motif; other site
316056003121	Walker B; other site
316056003122	D-loop; other site
316056003123	H-loop/switch region; other site
316056003124	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
316056003125	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316056003126	Walker A/P-loop; other site
316056003127	ATP binding site [chemical binding]; other site
316056003128	Q-loop/lid; other site
316056003129	ABC transporter signature motif; other site
316056003130	Walker B; other site
316056003131	D-loop; other site
316056003132	H-loop/switch region; other site
316056003133	putative acetyltransferase; Provisional; Region: PRK03624
316056003134	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056003135	Coenzyme A binding pocket [chemical binding]; other site
316056003136	Rrf2 family protein; Region: rrf2_super; TIGR00738
316056003137	Transcriptional regulator; Region: Rrf2; pfam02082
316056003138	archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700
316056003139	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
316056003140	Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959
316056003141	dimer interface [polypeptide binding]; other site
316056003142	acyl-activating enzyme (AAE) consensus motif; other site
316056003143	putative active site [active]
316056003144	putative AMP binding site [chemical binding]; other site
316056003145	putative CoA binding site [chemical binding]; other site
316056003146	chemical substrate binding site [chemical binding]; other site
316056003147	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
316056003148	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
316056003149	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
316056003150	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
316056003151	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
316056003152	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
316056003153	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
316056003154	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
316056003155	putative NAD(P) binding site [chemical binding]; other site
316056003156	structural Zn binding site [ion binding]; other site
316056003157	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
316056003158	MarR family; Region: MarR_2; pfam12802
316056003159	2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206
316056003160	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056003161	NAD(P) binding site [chemical binding]; other site
316056003162	active site
316056003163	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056003164	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
316056003165	substrate binding site [chemical binding]; other site
316056003166	oxyanion hole (OAH) forming residues; other site
316056003167	trimer interface [polypeptide binding]; other site
316056003168	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
316056003169	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
316056003170	active site
316056003171	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
316056003172	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
316056003173	acyl-activating enzyme (AAE) consensus motif; other site
316056003174	putative AMP binding site [chemical binding]; other site
316056003175	putative active site [active]
316056003176	putative CoA binding site [chemical binding]; other site
316056003177	enoyl-CoA hydratase; Provisional; Region: PRK05862
316056003178	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056003179	substrate binding site [chemical binding]; other site
316056003180	oxyanion hole (OAH) forming residues; other site
316056003181	trimer interface [polypeptide binding]; other site
316056003182	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
316056003183	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
316056003184	FAD binding site [chemical binding]; other site
316056003185	substrate binding pocket [chemical binding]; other site
316056003186	catalytic base [active]
316056003187	Fic family protein [Function unknown]; Region: COG3177
316056003188	Fic/DOC family; Region: Fic; pfam02661
316056003189	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
316056003190	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
316056003191	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
316056003192	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
316056003193	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
316056003194	substrate binding site [chemical binding]; other site
316056003195	ATP binding site [chemical binding]; other site
316056003196	Class I aldolases; Region: Aldolase_Class_I; cl17187
316056003197	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
316056003198	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
316056003199	NAD(P) binding site [chemical binding]; other site
316056003200	benzoate transport; Region: 2A0115; TIGR00895
316056003201	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056003202	putative substrate translocation pore; other site
316056003203	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056003204	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
316056003205	shikimate transporter; Provisional; Region: PRK09952
316056003206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056003207	putative substrate translocation pore; other site
316056003208	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
316056003209	active site
316056003210	catalytic residues [active]
316056003211	acyl-CoA synthetase; Validated; Region: PRK07638
316056003212	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056003213	AMP binding site [chemical binding]; other site
316056003214	active site
316056003215	acyl-activating enzyme (AAE) consensus motif; other site
316056003216	CoA binding site [chemical binding]; other site
316056003217	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
316056003218	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
316056003219	active site
316056003220	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
316056003221	active site
316056003222	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
316056003223	active site 2 [active]
316056003224	active site 1 [active]
316056003225	NHAD transporter family protein; Provisional; Region: PLN00137
316056003226	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
316056003227	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
316056003228	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
316056003229	putative [4Fe-4S] binding site [ion binding]; other site
316056003230	putative molybdopterin cofactor binding site [chemical binding]; other site
316056003231	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
316056003232	putative molybdopterin cofactor binding site; other site
316056003233	triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132
316056003234	Na+-transporting malonate decarboxylase, carboxybiotin decarboxylase subunit; Region: malonate_biotin; TIGR03136
316056003235	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
316056003236	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
316056003237	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
316056003238	Coenzyme A transferase; Region: CoA_trans; cl17247
316056003239	malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130
316056003240	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
316056003241	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
316056003242	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316056003243	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
316056003244	malonate decarboxylase holo-[acyl-carrier-protein] synthase; Region: malonate_mdcG; TIGR03135
316056003245	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
316056003246	carboxyltransferase (CT) interaction site; other site
316056003247	biotinylation site [posttranslational modification]; other site
316056003248	Malonate transporter MadL subunit; Region: MadL; cl04273
316056003249	Malonate/sodium symporter MadM subunit; Region: MadM; cl04274
316056003250	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
316056003251	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
316056003252	Walker A/P-loop; other site
316056003253	ATP binding site [chemical binding]; other site
316056003254	Q-loop/lid; other site
316056003255	ABC transporter signature motif; other site
316056003256	Walker B; other site
316056003257	D-loop; other site
316056003258	H-loop/switch region; other site
316056003259	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
316056003260	BioY family; Region: BioY; pfam02632
316056003261	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
316056003262	hexamer interface [polypeptide binding]; other site
316056003263	RNA binding site [nucleotide binding]; other site
316056003264	Histidine-zinc binding site [chemical binding]; other site
316056003265	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
316056003266	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316056003267	DNA-binding site [nucleotide binding]; DNA binding site
316056003268	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
316056003269	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
316056003270	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
316056003271	tetramer interface [polypeptide binding]; other site
316056003272	active site
316056003273	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
316056003274	DUF35 OB-fold domain; Region: DUF35; pfam01796
316056003275	thiolase; Provisional; Region: PRK06158
316056003276	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
316056003277	active site
316056003278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056003279	D-galactonate transporter; Region: 2A0114; TIGR00893
316056003280	putative substrate translocation pore; other site
316056003281	Coenzyme A transferase; Region: CoA_trans; cl17247
316056003282	Coenzyme A transferase; Region: CoA_trans; cl17247
316056003283	Acetokinase family; Region: Acetate_kinase; cl17229
316056003284	propionate/acetate kinase; Provisional; Region: PRK12379
316056003285	phosphate acetyltransferase; Reviewed; Region: PRK05632
316056003286	DRTGG domain; Region: DRTGG; pfam07085
316056003287	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
316056003288	Pyruvate formate lyase 1; Region: PFL1; cd01678
316056003289	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
316056003290	coenzyme A binding site [chemical binding]; other site
316056003291	active site
316056003292	catalytic residues [active]
316056003293	glycine loop; other site
316056003294	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
316056003295	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056003296	FeS/SAM binding site; other site
316056003297	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
316056003298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056003299	active site
316056003300	phosphorylation site [posttranslational modification]
316056003301	intermolecular recognition site; other site
316056003302	dimerization interface [polypeptide binding]; other site
316056003303	LytTr DNA-binding domain; Region: LytTR; pfam04397
316056003304	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
316056003305	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
316056003306	Histidine kinase; Region: His_kinase; pfam06580
316056003307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056003308	ATP binding site [chemical binding]; other site
316056003309	Mg2+ binding site [ion binding]; other site
316056003310	G-X-G motif; other site
316056003311	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
316056003312	Carbon starvation protein CstA; Region: CstA; pfam02554
316056003313	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
316056003314	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
316056003315	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
316056003316	Walker A motif; other site
316056003317	ATP binding site [chemical binding]; other site
316056003318	Walker B motif; other site
316056003319	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
316056003320	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
316056003321	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
316056003322	flagellar motor protein MotA; Validated; Region: PRK09110
316056003323	Flagellar motor switch protein FliM; Region: FliM; pfam02154
316056003324	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
316056003325	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
316056003326	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
316056003327	FliG C-terminal domain; Region: FliG_C; pfam01706
316056003328	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK13109
316056003329	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
316056003330	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
316056003331	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
316056003332	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
316056003333	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
316056003334	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
316056003335	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
316056003336	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12692
316056003337	Vibrio cholerae sialidase, lectin insertion; Region: Sial-lect-inser; pfam09264
316056003338	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
316056003339	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK06005
316056003340	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
316056003341	flagellar basal body P-ring protein; Reviewed; Region: flgI; PRK12789
316056003342	Uncharacterized conserved protein [Function unknown]; Region: COG3334
316056003343	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788
316056003344	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
316056003345	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
316056003346	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK12783
316056003347	flagellin; Reviewed; Region: PRK12687
316056003348	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
316056003349	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
316056003350	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
316056003351	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
316056003352	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
316056003353	flagellar motor protein MotB; Validated; Region: motB; PRK05996
316056003354	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
316056003355	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
316056003356	ligand binding site [chemical binding]; other site
316056003357	chemotaxis protein; Reviewed; Region: PRK12798
316056003358	Capsid protein (F protein); Region: Phage_F; cl15846
316056003359	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
316056003360	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
316056003361	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316056003362	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316056003363	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
316056003364	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
316056003365	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
316056003366	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
316056003367	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
316056003368	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
316056003369	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
316056003370	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
316056003371	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
316056003372	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
316056003373	Flagellar protein FlaF; Region: FlaF; pfam07309
316056003374	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794
316056003375	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
316056003376	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
316056003377	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK12781
316056003378	flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792
316056003379	FHIPEP family; Region: FHIPEP; pfam00771
316056003380	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK12780
316056003381	Rod binding protein; Region: Rod-binding; pfam10135
316056003382	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
316056003383	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316056003384	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056003385	DNA binding site [nucleotide binding]
316056003386	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
316056003387	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
316056003388	protein binding site [polypeptide binding]; other site
316056003389	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
316056003390	nudix motif; other site
316056003391	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
316056003392	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
316056003393	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
316056003394	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
316056003395	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
316056003396	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
316056003397	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
316056003398	allophanate hydrolase; Provisional; Region: PRK08186
316056003399	Amidase; Region: Amidase; pfam01425
316056003400	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
316056003401	classical (c) SDRs; Region: SDR_c; cd05233
316056003402	NAD(P) binding site [chemical binding]; other site
316056003403	active site
316056003404	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
316056003405	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
316056003406	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
316056003407	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
316056003408	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
316056003409	HSP70 interaction site [polypeptide binding]; other site
316056003410	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
316056003411	substrate binding site [polypeptide binding]; other site
316056003412	dimer interface [polypeptide binding]; other site
316056003413	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
316056003414	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
316056003415	NAD binding site [chemical binding]; other site
316056003416	homotetramer interface [polypeptide binding]; other site
316056003417	homodimer interface [polypeptide binding]; other site
316056003418	substrate binding site [chemical binding]; other site
316056003419	active site
316056003420	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
316056003421	catalytic core [active]
316056003422	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
316056003423	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
316056003424	Tetramer interface [polypeptide binding]; other site
316056003425	active site
316056003426	FMN-binding site [chemical binding]; other site
316056003427	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
316056003428	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
316056003429	metal ion-dependent adhesion site (MIDAS); other site
316056003430	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
316056003431	multidrug efflux protein; Reviewed; Region: PRK01766
316056003432	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
316056003433	cation binding site [ion binding]; other site
316056003434	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
316056003435	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
316056003436	RNA binding surface [nucleotide binding]; other site
316056003437	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056003438	S-adenosylmethionine binding site [chemical binding]; other site
316056003439	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
316056003440	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
316056003441	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
316056003442	TPP-binding site; other site
316056003443	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
316056003444	PYR/PP interface [polypeptide binding]; other site
316056003445	dimer interface [polypeptide binding]; other site
316056003446	TPP binding site [chemical binding]; other site
316056003447	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
316056003448	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
316056003449	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
316056003450	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
316056003451	putative active site [active]
316056003452	Zn binding site [ion binding]; other site
316056003453	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
316056003454	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
316056003455	putative active site [active]
316056003456	putative metal binding site [ion binding]; other site
316056003457	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
316056003458	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
316056003459	active site
316056003460	enoyl-CoA hydratase; Provisional; Region: PRK06688
316056003461	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056003462	substrate binding site [chemical binding]; other site
316056003463	oxyanion hole (OAH) forming residues; other site
316056003464	trimer interface [polypeptide binding]; other site
316056003465	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
316056003466	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
316056003467	active site
316056003468	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
316056003469	Transcriptional regulators [Transcription]; Region: FadR; COG2186
316056003470	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316056003471	DNA-binding site [nucleotide binding]; DNA binding site
316056003472	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
316056003473	Protein of unknown function, DUF1537; Region: DUF1537; pfam07005
316056003474	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
316056003475	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
316056003476	putative active site [active]
316056003477	metal binding site [ion binding]; metal-binding site
316056003478	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
316056003479	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
316056003480	inhibitor site; inhibition site
316056003481	active site
316056003482	dimer interface [polypeptide binding]; other site
316056003483	catalytic residue [active]
316056003484	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056003485	D-galactonate transporter; Region: 2A0114; TIGR00893
316056003486	putative substrate translocation pore; other site
316056003487	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
316056003488	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
316056003489	ligand binding site [chemical binding]; other site
316056003490	NAD binding site [chemical binding]; other site
316056003491	dimerization interface [polypeptide binding]; other site
316056003492	catalytic site [active]
316056003493	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
316056003494	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
316056003495	dimer interface [polypeptide binding]; other site
316056003496	active site
316056003497	glycine loop; other site
316056003498	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
316056003499	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
316056003500	active site
316056003501	NAD binding site [chemical binding]; other site
316056003502	metal binding site [ion binding]; metal-binding site
316056003503	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
316056003504	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
316056003505	Hexamer interface [polypeptide binding]; other site
316056003506	Hexagonal pore residue; other site
316056003507	propanediol utilization protein PduB; Provisional; Region: PRK15415
316056003508	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
316056003509	putative hexamer interface [polypeptide binding]; other site
316056003510	putative hexagonal pore; other site
316056003511	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
316056003512	putative hexamer interface [polypeptide binding]; other site
316056003513	putative hexagonal pore; other site
316056003514	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
316056003515	Hexamer interface [polypeptide binding]; other site
316056003516	Hexagonal pore residue; other site
316056003517	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
316056003518	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
316056003519	Hexamer interface [polypeptide binding]; other site
316056003520	Hexagonal pore residue; other site
316056003521	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
316056003522	Propanediol utilisation protein PduL; Region: PduL; pfam06130
316056003523	Propanediol utilisation protein PduL; Region: PduL; pfam06130
316056003524	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
316056003525	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
316056003526	nucleotide binding site [chemical binding]; other site
316056003527	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
316056003528	Flavoprotein; Region: Flavoprotein; cl08021
316056003529	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
316056003530	Hexamer/Pentamer interface [polypeptide binding]; other site
316056003531	central pore; other site
316056003532	Domain of unknown function (DUF336); Region: DUF336; pfam03928
316056003533	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
316056003534	putative catalytic cysteine [active]
316056003535	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
316056003536	Hexamer interface [polypeptide binding]; other site
316056003537	Hexagonal pore residue; other site
316056003538	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
316056003539	4Fe-4S binding domain; Region: Fer4; pfam00037
316056003540	4Fe-4S binding domain; Region: Fer4_6; pfam12837
316056003541	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
316056003542	S-adenosylmethionine synthetase; Validated; Region: PRK05250
316056003543	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
316056003544	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
316056003545	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
316056003546	Sensory domain found in PocR; Region: PocR; pfam10114
316056003547	Histidine kinase; Region: His_kinase; pfam06580
316056003548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056003549	ATP binding site [chemical binding]; other site
316056003550	Mg2+ binding site [ion binding]; other site
316056003551	G-X-G motif; other site
316056003552	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056003553	Response regulator receiver domain; Region: Response_reg; pfam00072
316056003554	active site
316056003555	phosphorylation site [posttranslational modification]
316056003556	intermolecular recognition site; other site
316056003557	dimerization interface [polypeptide binding]; other site
316056003558	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
316056003559	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316056003560	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
316056003561	propionate/acetate kinase; Provisional; Region: PRK12379
316056003562	putative active site [active]
316056003563	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
316056003564	Domain of unknown function DUF87; Region: DUF87; pfam01935
316056003565	AAA-like domain; Region: AAA_10; pfam12846
316056003566	Zonular occludens toxin (Zot); Region: Zot; cl17485
316056003567	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
316056003568	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
316056003569	active site
316056003570	metal binding site [ion binding]; metal-binding site
316056003571	DNA binding site [nucleotide binding]
316056003572	AAA domain; Region: AAA_27; pfam13514
316056003573	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056003574	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056003575	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
316056003576	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
316056003577	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056003578	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056003579	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056003580	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
316056003581	benzoylformate decarboxylase; Reviewed; Region: PRK07092
316056003582	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
316056003583	PYR/PP interface [polypeptide binding]; other site
316056003584	dimer interface [polypeptide binding]; other site
316056003585	TPP binding site [chemical binding]; other site
316056003586	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
316056003587	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
316056003588	TPP-binding site [chemical binding]; other site
316056003589	dimer interface [polypeptide binding]; other site
316056003590	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
316056003591	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316056003592	putative DNA binding site [nucleotide binding]; other site
316056003593	putative Zn2+ binding site [ion binding]; other site
316056003594	AsnC family; Region: AsnC_trans_reg; pfam01037
316056003595	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
316056003596	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
316056003597	metal binding site [ion binding]; metal-binding site
316056003598	putative dimer interface [polypeptide binding]; other site
316056003599	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
316056003600	Uncharacterized conserved protein [Function unknown]; Region: COG5476
316056003601	MlrC C-terminus; Region: MlrC_C; pfam07171
316056003602	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
316056003603	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316056003604	Walker A/P-loop; other site
316056003605	ATP binding site [chemical binding]; other site
316056003606	Q-loop/lid; other site
316056003607	ABC transporter signature motif; other site
316056003608	Walker B; other site
316056003609	D-loop; other site
316056003610	H-loop/switch region; other site
316056003611	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316056003612	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316056003613	Walker A/P-loop; other site
316056003614	ATP binding site [chemical binding]; other site
316056003615	Q-loop/lid; other site
316056003616	ABC transporter signature motif; other site
316056003617	Walker B; other site
316056003618	D-loop; other site
316056003619	H-loop/switch region; other site
316056003620	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316056003621	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
316056003622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056003623	dimer interface [polypeptide binding]; other site
316056003624	conserved gate region; other site
316056003625	putative PBP binding loops; other site
316056003626	ABC-ATPase subunit interface; other site
316056003627	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
316056003628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056003629	dimer interface [polypeptide binding]; other site
316056003630	conserved gate region; other site
316056003631	putative PBP binding loops; other site
316056003632	ABC-ATPase subunit interface; other site
316056003633	hypothetical protein; Provisional; Region: PRK07338
316056003634	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
316056003635	metal binding site [ion binding]; metal-binding site
316056003636	dimer interface [polypeptide binding]; other site
316056003637	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
316056003638	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
316056003639	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
316056003640	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
316056003641	putative molybdopterin cofactor binding site [chemical binding]; other site
316056003642	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
316056003643	putative molybdopterin cofactor binding site; other site
316056003644	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
316056003645	active site
316056003646	catalytic residue [active]
316056003647	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
316056003648	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
316056003649	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
316056003650	transcription elongation factor regulatory protein; Validated; Region: PRK06342
316056003651	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
316056003652	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
316056003653	putative catalytic site [active]
316056003654	putative phosphate binding site [ion binding]; other site
316056003655	active site
316056003656	metal binding site A [ion binding]; metal-binding site
316056003657	DNA binding site [nucleotide binding]
316056003658	putative AP binding site [nucleotide binding]; other site
316056003659	putative metal binding site B [ion binding]; other site
316056003660	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
316056003661	NMT1-like family; Region: NMT1_2; pfam13379
316056003662	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
316056003663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
316056003664	active site
316056003665	phosphorylation site [posttranslational modification]
316056003666	intermolecular recognition site; other site
316056003667	ANTAR domain; Region: ANTAR; pfam03861
316056003668	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
316056003669	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316056003670	Walker A/P-loop; other site
316056003671	ATP binding site [chemical binding]; other site
316056003672	Q-loop/lid; other site
316056003673	ABC transporter signature motif; other site
316056003674	Walker B; other site
316056003675	D-loop; other site
316056003676	H-loop/switch region; other site
316056003677	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316056003678	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
316056003679	Amidase; Region: Amidase; pfam01425
316056003680	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
316056003681	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316056003682	Walker A/P-loop; other site
316056003683	ATP binding site [chemical binding]; other site
316056003684	Q-loop/lid; other site
316056003685	ABC transporter signature motif; other site
316056003686	Walker B; other site
316056003687	D-loop; other site
316056003688	H-loop/switch region; other site
316056003689	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316056003690	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
316056003691	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
316056003692	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056003693	dimer interface [polypeptide binding]; other site
316056003694	conserved gate region; other site
316056003695	putative PBP binding loops; other site
316056003696	ABC-ATPase subunit interface; other site
316056003697	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
316056003698	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056003699	dimer interface [polypeptide binding]; other site
316056003700	conserved gate region; other site
316056003701	putative PBP binding loops; other site
316056003702	ABC-ATPase subunit interface; other site
316056003703	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
316056003704	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
316056003705	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
316056003706	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
316056003707	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056003708	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056003709	dimer interface [polypeptide binding]; other site
316056003710	phosphorylation site [posttranslational modification]
316056003711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056003712	ATP binding site [chemical binding]; other site
316056003713	Mg2+ binding site [ion binding]; other site
316056003714	G-X-G motif; other site
316056003715	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
316056003716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056003717	active site
316056003718	phosphorylation site [posttranslational modification]
316056003719	intermolecular recognition site; other site
316056003720	dimerization interface [polypeptide binding]; other site
316056003721	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
316056003722	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
316056003723	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
316056003724	NAD binding site [chemical binding]; other site
316056003725	catalytic Zn binding site [ion binding]; other site
316056003726	structural Zn binding site [ion binding]; other site
316056003727	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
316056003728	classical (c) SDRs; Region: SDR_c; cd05233
316056003729	NAD(P) binding site [chemical binding]; other site
316056003730	active site
316056003731	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
316056003732	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
316056003733	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
316056003734	catalytic site [active]
316056003735	active site
316056003736	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
316056003737	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
316056003738	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
316056003739	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
316056003740	active site
316056003741	catalytic site [active]
316056003742	Response regulator receiver domain; Region: Response_reg; pfam00072
316056003743	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056003744	active site
316056003745	phosphorylation site [posttranslational modification]
316056003746	intermolecular recognition site; other site
316056003747	dimerization interface [polypeptide binding]; other site
316056003748	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
316056003749	short chain dehydrogenase; Provisional; Region: PRK06701
316056003750	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
316056003751	NAD binding site [chemical binding]; other site
316056003752	metal binding site [ion binding]; metal-binding site
316056003753	active site
316056003754	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056003755	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056003756	ligand binding site [chemical binding]; other site
316056003757	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
316056003758	non-specific DNA interactions [nucleotide binding]; other site
316056003759	DNA binding site [nucleotide binding]
316056003760	sequence specific DNA binding site [nucleotide binding]; other site
316056003761	putative cAMP binding site [chemical binding]; other site
316056003762	phosphoglucomutase; Validated; Region: PRK07564
316056003763	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
316056003764	active site
316056003765	substrate binding site [chemical binding]; other site
316056003766	metal binding site [ion binding]; metal-binding site
316056003767	NnrU protein; Region: NnrU; pfam07298
316056003768	NnrS protein; Region: NnrS; pfam05940
316056003769	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
316056003770	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
316056003771	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
316056003772	PUCC protein; Region: PUCC; pfam03209
316056003773	Domain of unknown function (DUF2383); Region: DUF2383; pfam09537
316056003774	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
316056003775	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
316056003776	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
316056003777	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
316056003778	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
316056003779	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
316056003780	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
316056003781	domain interfaces; other site
316056003782	active site
316056003783	magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407
316056003784	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056003785	Walker A motif; other site
316056003786	ATP binding site [chemical binding]; other site
316056003787	Walker B motif; other site
316056003788	arginine finger; other site
316056003789	magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406
316056003790	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
316056003791	metal ion-dependent adhesion site (MIDAS); other site
316056003792	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056003793	putative active site [active]
316056003794	PAS fold; Region: PAS_3; pfam08447
316056003795	heme pocket [chemical binding]; other site
316056003796	PAS fold; Region: PAS_3; pfam08447
316056003797	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
316056003798	putative active site [active]
316056003799	heme pocket [chemical binding]; other site
316056003800	Helix-turn-helix domain; Region: HTH_18; pfam12833
316056003801	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
316056003802	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056003803	dimerization interface [polypeptide binding]; other site
316056003804	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056003805	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056003806	dimer interface [polypeptide binding]; other site
316056003807	putative CheW interface [polypeptide binding]; other site
316056003808	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
316056003809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
316056003810	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316056003811	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
316056003812	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056003813	sequence-specific DNA binding site [nucleotide binding]; other site
316056003814	salt bridge; other site
316056003815	Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549
316056003816	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
316056003817	substrate binding site [chemical binding]; other site
316056003818	active site
316056003819	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
316056003820	putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056
316056003821	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
316056003822	phytoene desaturase; Region: crtI_fam; TIGR02734
316056003823	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
316056003824	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
316056003825	active site lid residues [active]
316056003826	substrate binding pocket [chemical binding]; other site
316056003827	catalytic residues [active]
316056003828	substrate-Mg2+ binding site; other site
316056003829	aspartate-rich region 1; other site
316056003830	aspartate-rich region 2; other site
316056003831	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
316056003832	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
316056003833	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
316056003834	GIY-YIG motif/motif A; other site
316056003835	putative active site [active]
316056003836	putative metal binding site [ion binding]; other site
316056003837	peptide-modifying radical SAM enzyme CbpB; Region: rSAM_cobopep; TIGR04163
316056003838	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056003839	FeS/SAM binding site; other site
316056003840	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
316056003841	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
316056003842	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
316056003843	active site
316056003844	metal binding site [ion binding]; metal-binding site
316056003845	hexamer interface [polypeptide binding]; other site
316056003846	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
316056003847	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056003848	Walker A/P-loop; other site
316056003849	ATP binding site [chemical binding]; other site
316056003850	Q-loop/lid; other site
316056003851	ABC transporter signature motif; other site
316056003852	Walker B; other site
316056003853	D-loop; other site
316056003854	H-loop/switch region; other site
316056003855	TOBE domain; Region: TOBE_2; pfam08402
316056003856	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
316056003857	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056003858	dimer interface [polypeptide binding]; other site
316056003859	conserved gate region; other site
316056003860	putative PBP binding loops; other site
316056003861	ABC-ATPase subunit interface; other site
316056003862	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
316056003863	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056003864	dimer interface [polypeptide binding]; other site
316056003865	conserved gate region; other site
316056003866	ABC-ATPase subunit interface; other site
316056003867	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
316056003868	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
316056003869	Protein of unknown function (DUF3419); Region: DUF3419; pfam11899
316056003870	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056003871	Methyltransferase domain; Region: Methyltransf_31; pfam13847
316056003872	S-adenosylmethionine binding site [chemical binding]; other site
316056003873	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
316056003874	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
316056003875	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
316056003876	Cl binding site [ion binding]; other site
316056003877	oligomer interface [polypeptide binding]; other site
316056003878	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
316056003879	AAA domain; Region: AAA_18; pfam13238
316056003880	active site
316056003881	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
316056003882	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
316056003883	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
316056003884	active site
316056003885	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
316056003886	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
316056003887	Walker A/P-loop; other site
316056003888	ATP binding site [chemical binding]; other site
316056003889	Q-loop/lid; other site
316056003890	ABC transporter signature motif; other site
316056003891	Walker B; other site
316056003892	D-loop; other site
316056003893	H-loop/switch region; other site
316056003894	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
316056003895	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316056003896	Walker A/P-loop; other site
316056003897	ATP binding site [chemical binding]; other site
316056003898	Q-loop/lid; other site
316056003899	ABC transporter signature motif; other site
316056003900	Walker B; other site
316056003901	D-loop; other site
316056003902	H-loop/switch region; other site
316056003903	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316056003904	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
316056003905	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
316056003906	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845
316056003907	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
316056003908	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
316056003909	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316056003910	DNA-binding site [nucleotide binding]; DNA binding site
316056003911	UTRA domain; Region: UTRA; pfam07702
316056003912	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
316056003913	phytoene desaturase; Region: crtI_fam; TIGR02734
316056003914	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
316056003915	substrate binding pocket [chemical binding]; other site
316056003916	chain length determination region; other site
316056003917	substrate-Mg2+ binding site; other site
316056003918	catalytic residues [active]
316056003919	aspartate-rich region 1; other site
316056003920	active site lid residues [active]
316056003921	aspartate-rich region 2; other site
316056003922	O-methyltransferase; Region: Methyltransf_2; pfam00891
316056003923	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
316056003924	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
316056003925	putative NAD(P) binding site [chemical binding]; other site
316056003926	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
316056003927	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
316056003928	Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY).  Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980
316056003929	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
316056003930	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
316056003931	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
316056003932	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
316056003933	Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290
316056003934	subunit M interface; other site
316056003935	subunit H interface; other site
316056003936	quinone binding site; other site
316056003937	bacteriopheophytin binding site; other site
316056003938	bacteriochlorophyll binding site; other site
316056003939	cytochrome C subunit interface; other site
316056003940	Fe binding site [ion binding]; other site
316056003941	Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291
316056003942	subunit H interface; other site
316056003943	subunit L interface; other site
316056003944	bacteriopheophytin binding site; other site
316056003945	carotenoid binding site; other site
316056003946	bacteriochlorophyll binding site; other site
316056003947	cytochrome C interface; other site
316056003948	quinone binding site; other site
316056003949	Fe binding site [ion binding]; other site
316056003950	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
316056003951	PAS domain; Region: PAS_8; pfam13188
316056003952	putative active site [active]
316056003953	heme pocket [chemical binding]; other site
316056003954	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316056003955	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
316056003956	UbiA prenyltransferase family; Region: UbiA; pfam01040
316056003957	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056003958	PUCC protein; Region: PUCC; pfam03209
316056003959	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
316056003960	TspO/MBR family; Region: TspO_MBR; pfam03073
316056003961	Cytochrome c; Region: Cytochrom_C; cl11414
316056003962	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
316056003963	PAS domain; Region: PAS; smart00091
316056003964	putative active site [active]
316056003965	heme pocket [chemical binding]; other site
316056003966	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
316056003967	putative active site [active]
316056003968	heme pocket [chemical binding]; other site
316056003969	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316056003970	PAS fold; Region: PAS_2; pfam08446
316056003971	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
316056003972	GAF domain; Region: GAF; pfam01590
316056003973	Phytochrome region; Region: PHY; pfam00360
316056003974	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056003975	PAS domain; Region: PAS_9; pfam13426
316056003976	putative active site [active]
316056003977	heme pocket [chemical binding]; other site
316056003978	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
316056003979	heme binding pocket [chemical binding]; other site
316056003980	heme ligand [chemical binding]; other site
316056003981	B12 binding domain; Region: B12-binding_2; pfam02607
316056003982	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
316056003983	B12 binding site [chemical binding]; other site
316056003984	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
316056003985	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
316056003986	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
316056003987	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
316056003988	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
316056003989	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
316056003990	magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405
316056003991	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
316056003992	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
316056003993	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
316056003994	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
316056003995	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056003996	S-adenosylmethionine binding site [chemical binding]; other site
316056003997	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
316056003998	PUCC protein; Region: PUCC; pfam03209
316056003999	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581
316056004000	photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150
316056004001	subunit M interaction residues [polypeptide binding]; other site
316056004002	subunit L interaction residues [polypeptide binding]; other site
316056004003	putative proton transfer pathway, P1; other site
316056004004	putative proton transfer pathway, P2; other site
316056004005	Bacterial PH domain; Region: DUF304; pfam03703
316056004006	putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054
316056004007	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
316056004008	diiron binding motif [ion binding]; other site
316056004009	putative photosynthetic complex assembly protein 2; Region: photo_alph_chp2; TIGR03055
316056004010	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
316056004011	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
316056004012	substrate-cofactor binding pocket; other site
316056004013	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056004014	catalytic residue [active]
316056004015	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056004016	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056004017	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
316056004018	putative dimerization interface [polypeptide binding]; other site
316056004019	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
316056004020	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
316056004021	homodimer interface [polypeptide binding]; other site
316056004022	active site
316056004023	heterodimer interface [polypeptide binding]; other site
316056004024	catalytic residue [active]
316056004025	metal binding site [ion binding]; metal-binding site
316056004026	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
316056004027	multimerization interface [polypeptide binding]; other site
316056004028	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
316056004029	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056004030	Walker A motif; other site
316056004031	ATP binding site [chemical binding]; other site
316056004032	Walker B motif; other site
316056004033	arginine finger; other site
316056004034	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
316056004035	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
316056004036	TAP-like protein; Region: Abhydrolase_4; pfam08386
316056004037	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
316056004038	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
316056004039	homodimer interface [polypeptide binding]; other site
316056004040	substrate-cofactor binding pocket; other site
316056004041	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056004042	catalytic residue [active]
316056004043	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
316056004044	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
316056004045	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
316056004046	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
316056004047	Repair protein; Region: Repair_PSII; pfam04536
316056004048	Repair protein; Region: Repair_PSII; pfam04536
316056004049	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
316056004050	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
316056004051	CoA-transferase family III; Region: CoA_transf_3; pfam02515
316056004052	O-Antigen ligase; Region: Wzy_C; cl04850
316056004053	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
316056004054	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316056004055	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
316056004056	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
316056004057	putative active site [active]
316056004058	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
316056004059	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
316056004060	DNA binding site [nucleotide binding]
316056004061	active site
316056004062	putative glutathione S-transferase; Provisional; Region: PRK10357
316056004063	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
316056004064	putative C-terminal domain interface [polypeptide binding]; other site
316056004065	putative GSH binding site (G-site) [chemical binding]; other site
316056004066	putative dimer interface [polypeptide binding]; other site
316056004067	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
316056004068	N-terminal domain interface [polypeptide binding]; other site
316056004069	dimer interface [polypeptide binding]; other site
316056004070	putative substrate binding pocket (H-site) [chemical binding]; other site
316056004071	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
316056004072	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
316056004073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
316056004074	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
316056004075	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
316056004076	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056004077	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
316056004078	acyl-activating enzyme (AAE) consensus motif; other site
316056004079	acyl-activating enzyme (AAE) consensus motif; other site
316056004080	putative AMP binding site [chemical binding]; other site
316056004081	putative active site [active]
316056004082	putative CoA binding site [chemical binding]; other site
316056004083	SlyX; Region: SlyX; pfam04102
316056004084	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
316056004085	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
316056004086	CsbD-like; Region: CsbD; pfam05532
316056004087	Cupin domain; Region: Cupin_2; cl17218
316056004088	PAS fold; Region: PAS_4; pfam08448
316056004089	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056004090	putative active site [active]
316056004091	heme pocket [chemical binding]; other site
316056004092	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056004093	dimer interface [polypeptide binding]; other site
316056004094	phosphorylation site [posttranslational modification]
316056004095	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056004096	ATP binding site [chemical binding]; other site
316056004097	Mg2+ binding site [ion binding]; other site
316056004098	G-X-G motif; other site
316056004099	Response regulator receiver domain; Region: Response_reg; pfam00072
316056004100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056004101	active site
316056004102	phosphorylation site [posttranslational modification]
316056004103	intermolecular recognition site; other site
316056004104	dimerization interface [polypeptide binding]; other site
316056004105	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
316056004106	putative binding surface; other site
316056004107	active site
316056004108	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056004109	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056004110	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056004111	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
316056004112	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056004113	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056004114	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
316056004115	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
316056004116	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
316056004117	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
316056004118	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
316056004119	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
316056004120	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
316056004121	Walker A/P-loop; other site
316056004122	ATP binding site [chemical binding]; other site
316056004123	Q-loop/lid; other site
316056004124	ABC transporter signature motif; other site
316056004125	Walker B; other site
316056004126	D-loop; other site
316056004127	H-loop/switch region; other site
316056004128	TOBE domain; Region: TOBE; pfam03459
316056004129	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
316056004130	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
316056004131	Walker A/P-loop; other site
316056004132	ATP binding site [chemical binding]; other site
316056004133	Q-loop/lid; other site
316056004134	ABC transporter signature motif; other site
316056004135	Walker B; other site
316056004136	D-loop; other site
316056004137	H-loop/switch region; other site
316056004138	TOBE domain; Region: TOBE_2; pfam08402
316056004139	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
316056004140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056004141	dimer interface [polypeptide binding]; other site
316056004142	conserved gate region; other site
316056004143	putative PBP binding loops; other site
316056004144	ABC-ATPase subunit interface; other site
316056004145	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
316056004146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056004147	dimer interface [polypeptide binding]; other site
316056004148	conserved gate region; other site
316056004149	putative PBP binding loops; other site
316056004150	ABC-ATPase subunit interface; other site
316056004151	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
316056004152	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
316056004153	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
316056004154	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
316056004155	FMN binding site [chemical binding]; other site
316056004156	active site
316056004157	substrate binding site [chemical binding]; other site
316056004158	catalytic residue [active]
316056004159	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
316056004160	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
316056004161	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316056004162	TM-ABC transporter signature motif; other site
316056004163	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316056004164	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316056004165	TM-ABC transporter signature motif; other site
316056004166	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
316056004167	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316056004168	Walker A/P-loop; other site
316056004169	ATP binding site [chemical binding]; other site
316056004170	Q-loop/lid; other site
316056004171	ABC transporter signature motif; other site
316056004172	Walker B; other site
316056004173	D-loop; other site
316056004174	H-loop/switch region; other site
316056004175	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
316056004176	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316056004177	Walker A/P-loop; other site
316056004178	ATP binding site [chemical binding]; other site
316056004179	Q-loop/lid; other site
316056004180	ABC transporter signature motif; other site
316056004181	Walker B; other site
316056004182	D-loop; other site
316056004183	H-loop/switch region; other site
316056004184	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
316056004185	Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328
316056004186	putative ligand binding site [chemical binding]; other site
316056004187	lytic murein transglycosylase; Region: MltB_2; TIGR02283
316056004188	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316056004189	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316056004190	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
316056004191	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
316056004192	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
316056004193	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
316056004194	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056004195	non-specific DNA binding site [nucleotide binding]; other site
316056004196	salt bridge; other site
316056004197	sequence-specific DNA binding site [nucleotide binding]; other site
316056004198	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
316056004199	Domain of unknown function (DUF955); Region: DUF955; pfam06114
316056004200	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
316056004201	isocitrate lyase; Provisional; Region: PRK15063
316056004202	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
316056004203	tetramer interface [polypeptide binding]; other site
316056004204	active site
316056004205	Mg2+/Mn2+ binding site [ion binding]; other site
316056004206	isocitrate lyase; Region: PLN02892
316056004207	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
316056004208	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
316056004209	putative active site [active]
316056004210	putative metal binding site [ion binding]; other site
316056004211	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
316056004212	nudix motif; other site
316056004213	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
316056004214	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056004215	Coenzyme A binding pocket [chemical binding]; other site
316056004216	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056004217	HAMP domain; Region: HAMP; pfam00672
316056004218	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056004219	dimer interface [polypeptide binding]; other site
316056004220	phosphorylation site [posttranslational modification]
316056004221	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056004222	ATP binding site [chemical binding]; other site
316056004223	Mg2+ binding site [ion binding]; other site
316056004224	G-X-G motif; other site
316056004225	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056004226	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
316056004227	active site
316056004228	phosphorylation site [posttranslational modification]
316056004229	intermolecular recognition site; other site
316056004230	dimerization interface [polypeptide binding]; other site
316056004231	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056004232	DNA binding site [nucleotide binding]
316056004233	MarR family; Region: MarR_2; pfam12802
316056004234	Transcriptional regulators [Transcription]; Region: MarR; COG1846
316056004235	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
316056004236	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
316056004237	homodimer interface [polypeptide binding]; other site
316056004238	substrate-cofactor binding pocket; other site
316056004239	catalytic residue [active]
316056004240	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
316056004241	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
316056004242	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
316056004243	ATP binding site [chemical binding]; other site
316056004244	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
316056004245	hypothetical protein; Provisional; Region: PRK09256
316056004246	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
316056004247	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
316056004248	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
316056004249	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
316056004250	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
316056004251	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
316056004252	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
316056004253	lipoprotein signal peptidase; Provisional; Region: PRK14796
316056004254	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
316056004255	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
316056004256	active site
316056004257	HIGH motif; other site
316056004258	nucleotide binding site [chemical binding]; other site
316056004259	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
316056004260	active site
316056004261	KMSKS motif; other site
316056004262	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
316056004263	tRNA binding surface [nucleotide binding]; other site
316056004264	anticodon binding site; other site
316056004265	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
316056004266	RES domain; Region: RES; smart00953
316056004267	maltose O-acetyltransferase; Provisional; Region: PRK10092
316056004268	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
316056004269	active site
316056004270	substrate binding site [chemical binding]; other site
316056004271	trimer interface [polypeptide binding]; other site
316056004272	CoA binding site [chemical binding]; other site
316056004273	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
316056004274	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
316056004275	active site
316056004276	Riboflavin kinase; Region: Flavokinase; smart00904
316056004277	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
316056004278	B1 nucleotide binding pocket [chemical binding]; other site
316056004279	B2 nucleotide binding pocket [chemical binding]; other site
316056004280	CAS motifs; other site
316056004281	active site
316056004282	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
316056004283	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
316056004284	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
316056004285	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
316056004286	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
316056004287	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
316056004288	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
316056004289	riboflavin synthase subunit beta; Provisional; Region: PRK12419
316056004290	active site
316056004291	homopentamer interface [polypeptide binding]; other site
316056004292	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
316056004293	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
316056004294	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
316056004295	active site
316056004296	Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073
316056004297	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
316056004298	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
316056004299	Uncharacterized conserved protein [Function unknown]; Region: COG1565
316056004300	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
316056004301	Membrane fusogenic activity; Region: BMFP; pfam04380
316056004302	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
316056004303	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
316056004304	5S rRNA interface [nucleotide binding]; other site
316056004305	CTC domain interface [polypeptide binding]; other site
316056004306	L16 interface [polypeptide binding]; other site
316056004307	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
316056004308	putative active site [active]
316056004309	catalytic residue [active]
316056004310	GTP-binding protein YchF; Reviewed; Region: PRK09601
316056004311	YchF GTPase; Region: YchF; cd01900
316056004312	G1 box; other site
316056004313	GTP/Mg2+ binding site [chemical binding]; other site
316056004314	Switch I region; other site
316056004315	G2 box; other site
316056004316	Switch II region; other site
316056004317	G3 box; other site
316056004318	G4 box; other site
316056004319	G5 box; other site
316056004320	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
316056004321	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
316056004322	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
316056004323	putative active site [active]
316056004324	putative catalytic site [active]
316056004325	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
316056004326	putative active site [active]
316056004327	putative catalytic site [active]
316056004328	SnoaL-like domain; Region: SnoaL_2; pfam12680
316056004329	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
316056004330	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
316056004331	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
316056004332	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316056004333	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056004334	Walker A/P-loop; other site
316056004335	ATP binding site [chemical binding]; other site
316056004336	Q-loop/lid; other site
316056004337	ABC transporter signature motif; other site
316056004338	Walker B; other site
316056004339	D-loop; other site
316056004340	H-loop/switch region; other site
316056004341	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
316056004342	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
316056004343	NAD binding site [chemical binding]; other site
316056004344	homodimer interface [polypeptide binding]; other site
316056004345	active site
316056004346	substrate binding site [chemical binding]; other site
316056004347	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
316056004348	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
316056004349	putative active site [active]
316056004350	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
316056004351	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316056004352	active site
316056004353	motif I; other site
316056004354	motif II; other site
316056004355	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
316056004356	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
316056004357	putative active site [active]
316056004358	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
316056004359	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
316056004360	NADP binding site [chemical binding]; other site
316056004361	homopentamer interface [polypeptide binding]; other site
316056004362	substrate binding site [chemical binding]; other site
316056004363	active site
316056004364	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
316056004365	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
316056004366	putative ribose interaction site [chemical binding]; other site
316056004367	putative ADP binding site [chemical binding]; other site
316056004368	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
316056004369	active site
316056004370	nucleotide binding site [chemical binding]; other site
316056004371	HIGH motif; other site
316056004372	KMSKS motif; other site
316056004373	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
316056004374	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
316056004375	putative NAD(P) binding site [chemical binding]; other site
316056004376	active site
316056004377	putative substrate binding site [chemical binding]; other site
316056004378	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
316056004379	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
316056004380	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
316056004381	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
316056004382	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
316056004383	inhibitor-cofactor binding pocket; inhibition site
316056004384	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056004385	catalytic residue [active]
316056004386	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
316056004387	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
316056004388	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
316056004389	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
316056004390	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
316056004391	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
316056004392	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
316056004393	Cytochrome C' Region: Cytochrom_C_2; pfam01322
316056004394	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
316056004395	Cytochrome c; Region: Cytochrom_C; pfam00034
316056004396	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
316056004397	AsnC family; Region: AsnC_trans_reg; pfam01037
316056004398	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
316056004399	dimer interface [polypeptide binding]; other site
316056004400	substrate binding site [chemical binding]; other site
316056004401	ATP binding site [chemical binding]; other site
316056004402	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056004403	S-adenosylmethionine binding site [chemical binding]; other site
316056004404	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
316056004405	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
316056004406	putative active site [active]
316056004407	putative metal binding site [ion binding]; other site
316056004408	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316056004409	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
316056004410	serine racemase; Region: PLN02970
316056004411	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
316056004412	tetramer interface [polypeptide binding]; other site
316056004413	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056004414	catalytic residue [active]
316056004415	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056004416	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
316056004417	putative substrate translocation pore; other site
316056004418	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
316056004419	active site
316056004420	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
316056004421	Permease; Region: Permease; pfam02405
316056004422	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
316056004423	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
316056004424	Walker A/P-loop; other site
316056004425	ATP binding site [chemical binding]; other site
316056004426	Q-loop/lid; other site
316056004427	ABC transporter signature motif; other site
316056004428	Walker B; other site
316056004429	D-loop; other site
316056004430	H-loop/switch region; other site
316056004431	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
316056004432	mce related protein; Region: MCE; pfam02470
316056004433	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
316056004434	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
316056004435	putative binding surface; other site
316056004436	active site
316056004437	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
316056004438	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316056004439	catalytic loop [active]
316056004440	iron binding site [ion binding]; other site
316056004441	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
316056004442	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
316056004443	Methyltransferase domain; Region: Methyltransf_26; pfam13659
316056004444	Predicted membrane protein (DUF2335); Region: DUF2335; pfam10097
316056004445	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
316056004446	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056004447	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056004448	metal binding site [ion binding]; metal-binding site
316056004449	active site
316056004450	I-site; other site
316056004451	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056004452	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
316056004453	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056004454	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056004455	metal binding site [ion binding]; metal-binding site
316056004456	active site
316056004457	I-site; other site
316056004458	B12 binding domain; Region: B12-binding_2; pfam02607
316056004459	B12 binding domain; Region: B12-binding; pfam02310
316056004460	B12 binding site [chemical binding]; other site
316056004461	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
316056004462	active site
316056004463	oxyanion hole [active]
316056004464	Predicted integral membrane protein [Function unknown]; Region: COG0392
316056004465	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
316056004466	dimerization interface [polypeptide binding]; other site
316056004467	metal binding site [ion binding]; metal-binding site
316056004468	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
316056004469	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
316056004470	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056004471	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316056004472	dimerization interface [polypeptide binding]; other site
316056004473	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316056004474	Ligand Binding Site [chemical binding]; other site
316056004475	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
316056004476	catalytic core [active]
316056004477	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
316056004478	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
316056004479	methionine sulfoxide reductase B; Provisional; Region: PRK00222
316056004480	SelR domain; Region: SelR; pfam01641
316056004481	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
316056004482	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
316056004483	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
316056004484	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
316056004485	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
316056004486	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
316056004487	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913
316056004488	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
316056004489	flagellin; Reviewed; Region: PRK12688
316056004490	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
316056004491	Domain of Unknown Function (DUF1522); Region: DUF1522; pfam07482
316056004492	Domain of Unknown Function (DUF1522); Region: DUF1522; pfam07482
316056004493	flagellin; Reviewed; Region: PRK12688
316056004494	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
316056004495	Domain of Unknown Function (DUF1522); Region: DUF1522; pfam07482
316056004496	Domain of Unknown Function (DUF1522); Region: DUF1522; pfam07482
316056004497	flagellin; Reviewed; Region: PRK12688
316056004498	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
316056004499	Domain of Unknown Function (DUF1522); Region: DUF1522; pfam07482
316056004500	Domain of Unknown Function (DUF1522); Region: DUF1522; pfam07482
316056004501	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK12791
316056004502	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794
316056004503	chemotactic signal-response protein CheL; Provisional; Region: PRK12790
316056004504	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
316056004505	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
316056004506	flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787
316056004507	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
316056004508	PIN domain; Region: PIN_3; pfam13470
316056004509	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
316056004510	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
316056004511	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316056004512	NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231
316056004513	NmrA-like family; Region: NmrA; pfam05368
316056004514	putative NADP binding site [chemical binding]; other site
316056004515	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
316056004516	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
316056004517	SAF-like; Region: SAF_2; pfam13144
316056004518	flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170
316056004519	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
316056004520	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
316056004521	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
316056004522	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689
316056004523	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
316056004524	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785
316056004525	flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795
316056004526	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
316056004527	Uncharacterized conserved protein [Function unknown]; Region: COG3334
316056004528	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
316056004529	cell division protein ZipA; Provisional; Region: PRK03427
316056004530	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
316056004531	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
316056004532	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
316056004533	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
316056004534	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00732
316056004535	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
316056004536	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
316056004537	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
316056004538	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
316056004539	PAS domain; Region: PAS_9; pfam13426
316056004540	PAS domain; Region: PAS_9; pfam13426
316056004541	PAS fold; Region: PAS_4; pfam08448
316056004542	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056004543	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056004544	dimer interface [polypeptide binding]; other site
316056004545	phosphorylation site [posttranslational modification]
316056004546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056004547	ATP binding site [chemical binding]; other site
316056004548	Mg2+ binding site [ion binding]; other site
316056004549	G-X-G motif; other site
316056004550	Response regulator receiver domain; Region: Response_reg; pfam00072
316056004551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056004552	active site
316056004553	phosphorylation site [posttranslational modification]
316056004554	intermolecular recognition site; other site
316056004555	dimerization interface [polypeptide binding]; other site
316056004556	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
316056004557	trimer interface [polypeptide binding]; other site
316056004558	active site
316056004559	Tim44-like domain; Region: Tim44; pfam04280
316056004560	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
316056004561	glutathione s-transferase; Provisional; Region: PTZ00057
316056004562	GSH binding site (G-site) [chemical binding]; other site
316056004563	C-terminal domain interface [polypeptide binding]; other site
316056004564	dimer interface [polypeptide binding]; other site
316056004565	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
316056004566	dimer interface [polypeptide binding]; other site
316056004567	N-terminal domain interface [polypeptide binding]; other site
316056004568	substrate binding pocket (H-site) [chemical binding]; other site
316056004569	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
316056004570	fumarate hydratase; Provisional; Region: PRK15389
316056004571	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
316056004572	Fumarase C-terminus; Region: Fumerase_C; pfam05683
316056004573	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
316056004574	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
316056004575	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056004576	WHG domain; Region: WHG; pfam13305
316056004577	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
316056004578	glutamine synthetase; Region: PLN02284
316056004579	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
316056004580	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
316056004581	Protein of unknown function (DUF2735); Region: DUF2735; pfam10931
316056004582	glutaminase; Provisional; Region: PRK00971
316056004583	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
316056004584	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
316056004585	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
316056004586	catalytic residues [active]
316056004587	PilZ domain; Region: PilZ; pfam07238
316056004588	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
316056004589	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
316056004590	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
316056004591	AAA domain; Region: AAA_22; pfam13401
316056004592	AAA domain; Region: AAA_30; pfam13604
316056004593	Integrase core domain; Region: rve; pfam00665
316056004594	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
316056004595	recombinase A; Provisional; Region: recA; PRK09354
316056004596	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
316056004597	hexamer interface [polypeptide binding]; other site
316056004598	Walker A motif; other site
316056004599	ATP binding site [chemical binding]; other site
316056004600	Walker B motif; other site
316056004601	glycine dehydrogenase; Provisional; Region: PRK05367
316056004602	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
316056004603	tetramer interface [polypeptide binding]; other site
316056004604	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056004605	catalytic residue [active]
316056004606	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
316056004607	tetramer interface [polypeptide binding]; other site
316056004608	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056004609	catalytic residue [active]
316056004610	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
316056004611	lipoyl attachment site [posttranslational modification]; other site
316056004612	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
316056004613	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
316056004614	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
316056004615	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
316056004616	motif 1; other site
316056004617	active site
316056004618	motif 2; other site
316056004619	motif 3; other site
316056004620	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
316056004621	DHHA1 domain; Region: DHHA1; pfam02272
316056004622	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
316056004623	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
316056004624	TrkA-N domain; Region: TrkA_N; pfam02254
316056004625	putative cation:proton antiport protein; Provisional; Region: PRK10669
316056004626	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
316056004627	TrkA-N domain; Region: TrkA_N; pfam02254
316056004628	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
316056004629	Transposase; Region: DEDD_Tnp_IS110; pfam01548
316056004630	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
316056004631	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
316056004632	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
316056004633	isocitrate dehydrogenase; Validated; Region: PRK08299
316056004634	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
316056004635	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
316056004636	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
316056004637	putative active site [active]
316056004638	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
316056004639	transcription elongation factor regulatory protein; Validated; Region: PRK06342
316056004640	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
316056004641	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056004642	sequence-specific DNA binding site [nucleotide binding]; other site
316056004643	salt bridge; other site
316056004644	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
316056004645	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
316056004646	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
316056004647	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
316056004648	ATP binding site [chemical binding]; other site
316056004649	active site
316056004650	substrate binding site [chemical binding]; other site
316056004651	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
316056004652	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
316056004653	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
316056004654	putative active site [active]
316056004655	catalytic triad [active]
316056004656	Abi-like protein; Region: Abi_2; cl01988
316056004657	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
316056004658	CoenzymeA binding site [chemical binding]; other site
316056004659	subunit interaction site [polypeptide binding]; other site
316056004660	PHB binding site; other site
316056004661	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
316056004662	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
316056004663	dimerization interface [polypeptide binding]; other site
316056004664	ATP binding site [chemical binding]; other site
316056004665	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
316056004666	dimerization interface [polypeptide binding]; other site
316056004667	ATP binding site [chemical binding]; other site
316056004668	Acyltransferase family; Region: Acyl_transf_3; pfam01757
316056004669	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
316056004670	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
316056004671	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
316056004672	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
316056004673	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
316056004674	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
316056004675	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
316056004676	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
316056004677	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
316056004678	putative GSH binding site [chemical binding]; other site
316056004679	catalytic residues [active]
316056004680	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
316056004681	putative ADP-ribose binding site [chemical binding]; other site
316056004682	putative active site [active]
316056004683	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
316056004684	Beta-lactamase; Region: Beta-lactamase; pfam00144
316056004685	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
316056004686	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
316056004687	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316056004688	catalytic residue [active]
316056004689	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
316056004690	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
316056004691	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
316056004692	RNA binding surface [nucleotide binding]; other site
316056004693	Cupin domain; Region: Cupin_2; pfam07883
316056004694	glutamate racemase; Provisional; Region: PRK00865
316056004695	MOSC domain; Region: MOSC; pfam03473
316056004696	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
316056004697	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
316056004698	adenylosuccinate lyase; Provisional; Region: PRK07492
316056004699	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
316056004700	tetramer interface [polypeptide binding]; other site
316056004701	active site
316056004702	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
316056004703	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
316056004704	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
316056004705	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
316056004706	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
316056004707	substrate binding site [chemical binding]; other site
316056004708	hexamer interface [polypeptide binding]; other site
316056004709	metal binding site [ion binding]; metal-binding site
316056004710	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
316056004711	Ca2+ binding site [ion binding]; other site
316056004712	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
316056004713	putative active site pocket [active]
316056004714	cleavage site
316056004715	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
316056004716	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
316056004717	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
316056004718	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
316056004719	dimerization interface [polypeptide binding]; other site
316056004720	ligand binding site [chemical binding]; other site
316056004721	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
316056004722	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316056004723	Walker A/P-loop; other site
316056004724	ATP binding site [chemical binding]; other site
316056004725	Q-loop/lid; other site
316056004726	ABC transporter signature motif; other site
316056004727	Walker B; other site
316056004728	D-loop; other site
316056004729	H-loop/switch region; other site
316056004730	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
316056004731	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316056004732	Walker A/P-loop; other site
316056004733	ATP binding site [chemical binding]; other site
316056004734	Q-loop/lid; other site
316056004735	ABC transporter signature motif; other site
316056004736	Walker B; other site
316056004737	D-loop; other site
316056004738	H-loop/switch region; other site
316056004739	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
316056004740	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
316056004741	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316056004742	TM-ABC transporter signature motif; other site
316056004743	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316056004744	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316056004745	TM-ABC transporter signature motif; other site
316056004746	ATP-grasp domain; Region: ATP-grasp_4; cl17255
316056004747	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
316056004748	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056004749	FeS/SAM binding site; other site
316056004750	HemN C-terminal domain; Region: HemN_C; pfam06969
316056004751	4Fe-4S binding domain; Region: Fer4; pfam00037
316056004752	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
316056004753	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
316056004754	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
316056004755	putative hydrophobic ligand binding site [chemical binding]; other site
316056004756	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
316056004757	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316056004758	catalytic loop [active]
316056004759	iron binding site [ion binding]; other site
316056004760	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
316056004761	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
316056004762	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
316056004763	MoxR-like ATPases [General function prediction only]; Region: COG0714
316056004764	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056004765	Walker A motif; other site
316056004766	ATP binding site [chemical binding]; other site
316056004767	Walker B motif; other site
316056004768	arginine finger; other site
316056004769	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
316056004770	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
316056004771	metal ion-dependent adhesion site (MIDAS); other site
316056004772	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
316056004773	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
316056004774	XdhC Rossmann domain; Region: XdhC_C; pfam13478
316056004775	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
316056004776	putative MPT binding site; other site
316056004777	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
316056004778	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
316056004779	Ligand binding site; other site
316056004780	metal-binding site
316056004781	Avidin family; Region: Avidin; pfam01382
316056004782	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
316056004783	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
316056004784	Protein of unknown function, DUF488; Region: DUF488; pfam04343
316056004785	Protein of unknown function DUF72; Region: DUF72; pfam01904
316056004786	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
316056004787	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
316056004788	Ligand binding site; other site
316056004789	Putative Catalytic site; other site
316056004790	DXD motif; other site
316056004791	Predicted membrane protein [Function unknown]; Region: COG2246
316056004792	GtrA-like protein; Region: GtrA; pfam04138
316056004793	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
316056004794	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
316056004795	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316056004796	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
316056004797	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
316056004798	substrate binding site [chemical binding]; other site
316056004799	ATP binding site [chemical binding]; other site
316056004800	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056004801	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056004802	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056004803	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056004804	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056004805	multidrug efflux protein; Reviewed; Region: PRK09579
316056004806	Protein export membrane protein; Region: SecD_SecF; cl14618
316056004807	Protein export membrane protein; Region: SecD_SecF; cl14618
316056004808	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
316056004809	hydroxyglutarate oxidase; Provisional; Region: PRK11728
316056004810	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
316056004811	PGAP1-like protein; Region: PGAP1; pfam07819
316056004812	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
316056004813	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
316056004814	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
316056004815	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
316056004816	Phasin protein; Region: Phasin_2; cl11491
316056004817	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
316056004818	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316056004819	Walker A/P-loop; other site
316056004820	ATP binding site [chemical binding]; other site
316056004821	Q-loop/lid; other site
316056004822	ABC transporter signature motif; other site
316056004823	Walker B; other site
316056004824	D-loop; other site
316056004825	H-loop/switch region; other site
316056004826	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
316056004827	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316056004828	Walker A/P-loop; other site
316056004829	ATP binding site [chemical binding]; other site
316056004830	Q-loop/lid; other site
316056004831	ABC transporter signature motif; other site
316056004832	Walker B; other site
316056004833	D-loop; other site
316056004834	H-loop/switch region; other site
316056004835	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
316056004836	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316056004837	TM-ABC transporter signature motif; other site
316056004838	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316056004839	TM-ABC transporter signature motif; other site
316056004840	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
316056004841	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340
316056004842	putative ligand binding site [chemical binding]; other site
316056004843	hypothetical protein; Provisional; Region: PRK05463
316056004844	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056004845	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056004846	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
316056004847	dimerization interface [polypeptide binding]; other site
316056004848	allantoate amidohydrolase; Reviewed; Region: PRK09290
316056004849	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
316056004850	active site
316056004851	metal binding site [ion binding]; metal-binding site
316056004852	dimer interface [polypeptide binding]; other site
316056004853	glycerate dehydrogenase; Provisional; Region: PRK06487
316056004854	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
316056004855	NAD binding site [chemical binding]; other site
316056004856	amidase; Provisional; Region: PRK07486
316056004857	Amidase; Region: Amidase; pfam01425
316056004858	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
316056004859	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
316056004860	Moco binding site; other site
316056004861	metal coordination site [ion binding]; other site
316056004862	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
316056004863	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
316056004864	enoyl-CoA hydratase; Provisional; Region: PRK05981
316056004865	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056004866	substrate binding site [chemical binding]; other site
316056004867	oxyanion hole (OAH) forming residues; other site
316056004868	trimer interface [polypeptide binding]; other site
316056004869	enoyl-CoA hydratase; Provisional; Region: PRK06494
316056004870	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056004871	substrate binding site [chemical binding]; other site
316056004872	oxyanion hole (OAH) forming residues; other site
316056004873	trimer interface [polypeptide binding]; other site
316056004874	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
316056004875	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
316056004876	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056004877	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
316056004878	acyl-activating enzyme (AAE) consensus motif; other site
316056004879	acyl-activating enzyme (AAE) consensus motif; other site
316056004880	putative AMP binding site [chemical binding]; other site
316056004881	putative active site [active]
316056004882	putative CoA binding site [chemical binding]; other site
316056004883	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
316056004884	short chain dehydrogenase; Provisional; Region: PRK07677
316056004885	NAD(P) binding site [chemical binding]; other site
316056004886	substrate binding site [chemical binding]; other site
316056004887	homotetramer interface [polypeptide binding]; other site
316056004888	active site
316056004889	homodimer interface [polypeptide binding]; other site
316056004890	enoyl-CoA hydratase; Provisional; Region: PRK07509
316056004891	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056004892	substrate binding site [chemical binding]; other site
316056004893	oxyanion hole (OAH) forming residues; other site
316056004894	trimer interface [polypeptide binding]; other site
316056004895	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
316056004896	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056004897	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
316056004898	putative dimerization interface [polypeptide binding]; other site
316056004899	Predicted membrane protein [Function unknown]; Region: COG2855
316056004900	HAMP domain; Region: HAMP; pfam00672
316056004901	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
316056004902	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
316056004903	putative active site [active]
316056004904	heme pocket [chemical binding]; other site
316056004905	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056004906	dimer interface [polypeptide binding]; other site
316056004907	phosphorylation site [posttranslational modification]
316056004908	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056004909	ATP binding site [chemical binding]; other site
316056004910	Mg2+ binding site [ion binding]; other site
316056004911	G-X-G motif; other site
316056004912	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
316056004913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056004914	active site
316056004915	phosphorylation site [posttranslational modification]
316056004916	intermolecular recognition site; other site
316056004917	dimerization interface [polypeptide binding]; other site
316056004918	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
316056004919	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
316056004920	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
316056004921	thiolase; Provisional; Region: PRK06158
316056004922	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
316056004923	active site
316056004924	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
316056004925	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
316056004926	DUF35 OB-fold domain; Region: DUF35; pfam01796
316056004927	amidase; Provisional; Region: PRK07056
316056004928	Amidase; Region: Amidase; cl11426
316056004929	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
316056004930	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
316056004931	hypothetical protein; Provisional; Region: PRK08266
316056004932	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
316056004933	PYR/PP interface [polypeptide binding]; other site
316056004934	dimer interface [polypeptide binding]; other site
316056004935	TPP binding site [chemical binding]; other site
316056004936	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
316056004937	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
316056004938	TPP-binding site [chemical binding]; other site
316056004939	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
316056004940	putative substrate binding pocket [chemical binding]; other site
316056004941	trimer interface [polypeptide binding]; other site
316056004942	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
316056004943	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
316056004944	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316056004945	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316056004946	TM-ABC transporter signature motif; other site
316056004947	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
316056004948	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316056004949	TM-ABC transporter signature motif; other site
316056004950	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
316056004951	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316056004952	Walker A/P-loop; other site
316056004953	ATP binding site [chemical binding]; other site
316056004954	Q-loop/lid; other site
316056004955	ABC transporter signature motif; other site
316056004956	Walker B; other site
316056004957	D-loop; other site
316056004958	H-loop/switch region; other site
316056004959	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
316056004960	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316056004961	Walker A/P-loop; other site
316056004962	ATP binding site [chemical binding]; other site
316056004963	Q-loop/lid; other site
316056004964	ABC transporter signature motif; other site
316056004965	Walker B; other site
316056004966	D-loop; other site
316056004967	H-loop/switch region; other site
316056004968	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
316056004969	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
316056004970	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
316056004971	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
316056004972	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
316056004973	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
316056004974	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
316056004975	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
316056004976	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
316056004977	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
316056004978	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
316056004979	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
316056004980	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
316056004981	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
316056004982	Predicted flavoproteins [General function prediction only]; Region: COG2081
316056004983	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
316056004984	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
316056004985	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056004986	dimerization interface [polypeptide binding]; other site
316056004987	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056004988	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056004989	dimer interface [polypeptide binding]; other site
316056004990	putative CheW interface [polypeptide binding]; other site
316056004991	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
316056004992	heme-binding site [chemical binding]; other site
316056004993	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056004994	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056004995	dimer interface [polypeptide binding]; other site
316056004996	putative CheW interface [polypeptide binding]; other site
316056004997	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
316056004998	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
316056004999	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
316056005000	B12 binding domain; Region: B12-binding; pfam02310
316056005001	B12 binding site [chemical binding]; other site
316056005002	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
316056005003	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
316056005004	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
316056005005	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
316056005006	substrate binding pocket [chemical binding]; other site
316056005007	substrate-Mg2+ binding site; other site
316056005008	aspartate-rich region 1; other site
316056005009	aspartate-rich region 2; other site
316056005010	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
316056005011	active site lid residues [active]
316056005012	substrate binding pocket [chemical binding]; other site
316056005013	catalytic residues [active]
316056005014	substrate-Mg2+ binding site; other site
316056005015	aspartate-rich region 1; other site
316056005016	aspartate-rich region 2; other site
316056005017	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
316056005018	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
316056005019	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
316056005020	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
316056005021	Active site cavity [active]
316056005022	catalytic acid [active]
316056005023	hypothetical protein; Provisional; Region: PRK07077
316056005024	Domain of unknown function (DUF336); Region: DUF336; pfam03928
316056005025	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
316056005026	active site triad [active]
316056005027	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
316056005028	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056005029	FeS/SAM binding site; other site
316056005030	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
316056005031	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
316056005032	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
316056005033	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
316056005034	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
316056005035	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
316056005036	inhibitor-cofactor binding pocket; inhibition site
316056005037	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056005038	catalytic residue [active]
316056005039	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
316056005040	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
316056005041	metal binding site [ion binding]; metal-binding site
316056005042	putative dimer interface [polypeptide binding]; other site
316056005043	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
316056005044	dimerization interface [polypeptide binding]; other site
316056005045	metal binding site [ion binding]; metal-binding site
316056005046	Uncharacterized conserved protein [Function unknown]; Region: COG4544
316056005047	DNA Polymerase Y-family; Region: PolY_like; cd03468
316056005048	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
316056005049	DNA binding site [nucleotide binding]
316056005050	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
316056005051	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
316056005052	putative active site [active]
316056005053	putative PHP Thumb interface [polypeptide binding]; other site
316056005054	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
316056005055	generic binding surface I; other site
316056005056	generic binding surface II; other site
316056005057	PAS fold; Region: PAS_3; pfam08447
316056005058	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
316056005059	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056005060	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056005061	metal binding site [ion binding]; metal-binding site
316056005062	active site
316056005063	I-site; other site
316056005064	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056005065	PBP superfamily domain; Region: PBP_like_2; pfam12849
316056005066	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
316056005067	enoyl-CoA hydratase; Provisional; Region: PRK05862
316056005068	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056005069	substrate binding site [chemical binding]; other site
316056005070	oxyanion hole (OAH) forming residues; other site
316056005071	trimer interface [polypeptide binding]; other site
316056005072	RNA polymerase sigma factor; Provisional; Region: PRK12512
316056005073	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316056005074	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316056005075	DNA binding residues [nucleotide binding]
316056005076	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
316056005077	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
316056005078	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056005079	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056005080	metal binding site [ion binding]; metal-binding site
316056005081	active site
316056005082	I-site; other site
316056005083	TIGR03809 family protein; Region: TIGR03809
316056005084	twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808
316056005085	putative cofactor-binding repeat; Region: RR_fam_repeat; TIGR03807
316056005086	putative cofactor-binding repeat; Region: RR_fam_repeat; TIGR03807
316056005087	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
316056005088	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
316056005089	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
316056005090	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
316056005091	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
316056005092	molybdopterin cofactor binding site [chemical binding]; other site
316056005093	substrate binding site [chemical binding]; other site
316056005094	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
316056005095	molybdopterin cofactor binding site; other site
316056005096	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
316056005097	putative substrate binding pocket [chemical binding]; other site
316056005098	AC domain interface; other site
316056005099	catalytic triad [active]
316056005100	AB domain interface; other site
316056005101	membrane ATPase/protein kinase; Provisional; Region: PRK09435
316056005102	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
316056005103	Walker A; other site
316056005104	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
316056005105	Protein of unknown function DUF86; Region: DUF86; cl01031
316056005106	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
316056005107	active site
316056005108	NTP binding site [chemical binding]; other site
316056005109	metal binding triad [ion binding]; metal-binding site
316056005110	antibiotic binding site [chemical binding]; other site
316056005111	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
316056005112	homotetrameric interface [polypeptide binding]; other site
316056005113	putative active site [active]
316056005114	metal binding site [ion binding]; metal-binding site
316056005115	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
316056005116	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
316056005117	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
316056005118	active site
316056005119	substrate binding site [chemical binding]; other site
316056005120	coenzyme B12 binding site [chemical binding]; other site
316056005121	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
316056005122	B12 binding site [chemical binding]; other site
316056005123	cobalt ligand [ion binding]; other site
316056005124	Uncharacterized conserved protein [Function unknown]; Region: COG3791
316056005125	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
316056005126	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
316056005127	heterodimer interface [polypeptide binding]; other site
316056005128	substrate interaction site [chemical binding]; other site
316056005129	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
316056005130	catalytic center binding site [active]
316056005131	ATP binding site [chemical binding]; other site
316056005132	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
316056005133	homooctamer interface [polypeptide binding]; other site
316056005134	active site
316056005135	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
316056005136	dihydropteroate synthase; Region: DHPS; TIGR01496
316056005137	substrate binding pocket [chemical binding]; other site
316056005138	dimer interface [polypeptide binding]; other site
316056005139	inhibitor binding site; inhibition site
316056005140	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
316056005141	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056005142	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
316056005143	Walker A motif; other site
316056005144	ATP binding site [chemical binding]; other site
316056005145	hypothetical protein; Validated; Region: PRK09104
316056005146	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
316056005147	metal binding site [ion binding]; metal-binding site
316056005148	putative dimer interface [polypeptide binding]; other site
316056005149	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
316056005150	active site
316056005151	Zn binding site [ion binding]; other site
316056005152	Transposase domain (DUF772); Region: DUF772; pfam05598
316056005153	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
316056005154	Predicted transcriptional regulator [Transcription]; Region: COG4957
316056005155	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
316056005156	DnaA box-binding interface [nucleotide binding]; other site
316056005157	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
316056005158	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
316056005159	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056005160	putative active site [active]
316056005161	heme pocket [chemical binding]; other site
316056005162	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056005163	dimer interface [polypeptide binding]; other site
316056005164	phosphorylation site [posttranslational modification]
316056005165	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056005166	ATP binding site [chemical binding]; other site
316056005167	Mg2+ binding site [ion binding]; other site
316056005168	G-X-G motif; other site
316056005169	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
316056005170	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
316056005171	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
316056005172	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
316056005173	Predicted integral membrane protein [Function unknown]; Region: COG5436
316056005174	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
316056005175	Transglycosylase; Region: Transgly; pfam00912
316056005176	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
316056005177	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
316056005178	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
316056005179	Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in bacteria, P0 in eukaryotes, and L10e in archaea, as well as uncharacterized P0-like eukaryotic proteins. In all three kingdoms, L10 forms a tight complex with...; Region: Ribosomal_L10_P0; cl00376
316056005180	AAA ATPase domain; Region: AAA_16; pfam13191
316056005181	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
316056005182	hypothetical protein; Provisional; Region: PRK05170
316056005183	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
316056005184	active site
316056005185	nucleophile elbow; other site
316056005186	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
316056005187	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
316056005188	active site
316056005189	catalytic triad [active]
316056005190	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056005191	putative substrate translocation pore; other site
316056005192	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316056005193	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056005194	dimer interface [polypeptide binding]; other site
316056005195	putative CheW interface [polypeptide binding]; other site
316056005196	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
316056005197	hypothetical protein; Provisional; Region: PRK09272
316056005198	Uncharacterized conserved protein [Function unknown]; Region: COG5323
316056005199	Terminase-like family; Region: Terminase_6; pfam03237
316056005200	Phage-related protein [Function unknown]; Region: COG4695
316056005201	Phage portal protein; Region: Phage_portal; pfam04860
316056005202	PilZ domain; Region: PilZ; pfam07238
316056005203	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
316056005204	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
316056005205	Phage capsid family; Region: Phage_capsid; pfam05065
316056005206	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
316056005207	Domain of unknown function (DUF2019); Region: DUF2019; pfam09450
316056005208	Domain of unknown function (DUF2019); Region: DUF2019; pfam09450
316056005209	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
316056005210	active site
316056005211	substrate binding sites [chemical binding]; other site
316056005212	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
316056005213	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
316056005214	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
316056005215	oligomerization interface [polypeptide binding]; other site
316056005216	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
316056005217	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
316056005218	Phage major tail protein 2; Region: Phage_tail_2; cl11463
316056005219	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
316056005220	Conserved hypothetical phage protein (DUF2376); Region: DUF2376; cl09774
316056005221	Phage-related minor tail protein [Function unknown]; Region: COG5281
316056005222	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
316056005223	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
316056005224	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
316056005225	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
316056005226	NlpC/P60 family; Region: NLPC_P60; cl17555
316056005227	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
316056005228	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
316056005229	Putative phage tail protein; Region: Phage-tail_3; pfam13550
316056005230	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
316056005231	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056005232	S-adenosylmethionine binding site [chemical binding]; other site
316056005233	Methyltransferase domain; Region: Methyltransf_31; pfam13847
316056005234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056005235	S-adenosylmethionine binding site [chemical binding]; other site
316056005236	Predicted chitinase [General function prediction only]; Region: COG3179
316056005237	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316056005238	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056005239	active site
316056005240	phosphorylation site [posttranslational modification]
316056005241	intermolecular recognition site; other site
316056005242	dimerization interface [polypeptide binding]; other site
316056005243	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056005244	DNA binding site [nucleotide binding]
316056005245	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056005246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056005247	ATP binding site [chemical binding]; other site
316056005248	Mg2+ binding site [ion binding]; other site
316056005249	G-X-G motif; other site
316056005250	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
316056005251	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
316056005252	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
316056005253	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056005254	binding surface
316056005255	TPR motif; other site
316056005256	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
316056005257	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
316056005258	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
316056005259	amino acid transporter; Region: 2A0306; TIGR00909
316056005260	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
316056005261	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
316056005262	diiron binding motif [ion binding]; other site
316056005263	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
316056005264	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316056005265	catalytic loop [active]
316056005266	iron binding site [ion binding]; other site
316056005267	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
316056005268	diiron binding motif [ion binding]; other site
316056005269	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
316056005270	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
316056005271	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
316056005272	protein binding site [polypeptide binding]; other site
316056005273	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
316056005274	protein binding site [polypeptide binding]; other site
316056005275	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316056005276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056005277	active site
316056005278	phosphorylation site [posttranslational modification]
316056005279	intermolecular recognition site; other site
316056005280	dimerization interface [polypeptide binding]; other site
316056005281	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056005282	DNA binding site [nucleotide binding]
316056005283	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056005284	dimerization interface [polypeptide binding]; other site
316056005285	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056005286	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056005287	dimer interface [polypeptide binding]; other site
316056005288	putative CheW interface [polypeptide binding]; other site
316056005289	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
316056005290	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056005291	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056005292	metal binding site [ion binding]; metal-binding site
316056005293	active site
316056005294	I-site; other site
316056005295	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056005296	dimerization interface [polypeptide binding]; other site
316056005297	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056005298	dimer interface [polypeptide binding]; other site
316056005299	phosphorylation site [posttranslational modification]
316056005300	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056005301	ATP binding site [chemical binding]; other site
316056005302	Mg2+ binding site [ion binding]; other site
316056005303	G-X-G motif; other site
316056005304	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
316056005305	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
316056005306	metal binding triad; other site
316056005307	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
316056005308	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
316056005309	metal binding triad; other site
316056005310	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
316056005311	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056005312	PAS fold; Region: PAS_3; pfam08447
316056005313	putative active site [active]
316056005314	heme pocket [chemical binding]; other site
316056005315	PAS fold; Region: PAS_7; pfam12860
316056005316	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056005317	dimer interface [polypeptide binding]; other site
316056005318	phosphorylation site [posttranslational modification]
316056005319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056005320	ATP binding site [chemical binding]; other site
316056005321	Mg2+ binding site [ion binding]; other site
316056005322	G-X-G motif; other site
316056005323	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
316056005324	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
316056005325	Cation efflux family; Region: Cation_efflux; cl00316
316056005326	Cation efflux family; Region: Cation_efflux; cl00316
316056005327	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
316056005328	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
316056005329	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
316056005330	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
316056005331	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
316056005332	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
316056005333	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
316056005334	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
316056005335	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
316056005336	formyl-coenzyme A transferase; Provisional; Region: PRK05398
316056005337	CoA-transferase family III; Region: CoA_transf_3; pfam02515
316056005338	Transcriptional regulators [Transcription]; Region: GntR; COG1802
316056005339	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316056005340	DNA-binding site [nucleotide binding]; DNA binding site
316056005341	FCD domain; Region: FCD; pfam07729
316056005342	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
316056005343	potassium uptake protein; Region: kup; TIGR00794
316056005344	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
316056005345	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
316056005346	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
316056005347	MbtH-like protein; Region: MbtH; smart00923
316056005348	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
316056005349	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
316056005350	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
316056005351	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
316056005352	Walker A/P-loop; other site
316056005353	ATP binding site [chemical binding]; other site
316056005354	Q-loop/lid; other site
316056005355	ABC transporter signature motif; other site
316056005356	Walker B; other site
316056005357	D-loop; other site
316056005358	H-loop/switch region; other site
316056005359	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
316056005360	FtsX-like permease family; Region: FtsX; pfam02687
316056005361	macrolide transporter subunit MacA; Provisional; Region: PRK11578
316056005362	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056005363	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056005364	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056005365	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056005366	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
316056005367	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
316056005368	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056005369	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056005370	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
316056005371	Protein export membrane protein; Region: SecD_SecF; cl14618
316056005372	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
316056005373	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056005374	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056005375	dimer interface [polypeptide binding]; other site
316056005376	phosphorylation site [posttranslational modification]
316056005377	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056005378	ATP binding site [chemical binding]; other site
316056005379	Mg2+ binding site [ion binding]; other site
316056005380	G-X-G motif; other site
316056005381	Response regulator receiver domain; Region: Response_reg; pfam00072
316056005382	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056005383	active site
316056005384	phosphorylation site [posttranslational modification]
316056005385	intermolecular recognition site; other site
316056005386	dimerization interface [polypeptide binding]; other site
316056005387	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
316056005388	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
316056005389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056005390	active site
316056005391	phosphorylation site [posttranslational modification]
316056005392	intermolecular recognition site; other site
316056005393	dimerization interface [polypeptide binding]; other site
316056005394	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056005395	DNA binding site [nucleotide binding]
316056005396	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
316056005397	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
316056005398	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
316056005399	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
316056005400	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
316056005401	molybdopterin cofactor binding site [chemical binding]; other site
316056005402	substrate binding site [chemical binding]; other site
316056005403	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
316056005404	molybdopterin cofactor binding site; other site
316056005405	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
316056005406	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056005407	FeS/SAM binding site; other site
316056005408	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
316056005409	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
316056005410	active site
316056005411	SAM binding site [chemical binding]; other site
316056005412	homodimer interface [polypeptide binding]; other site
316056005413	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
316056005414	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
316056005415	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
316056005416	active site
316056005417	SAM binding site [chemical binding]; other site
316056005418	homodimer interface [polypeptide binding]; other site
316056005419	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
316056005420	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
316056005421	active site
316056005422	SAM binding site [chemical binding]; other site
316056005423	putative homodimer interface [polypeptide binding]; other site
316056005424	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
316056005425	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
316056005426	S-adenosylmethionine binding site [chemical binding]; other site
316056005427	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
316056005428	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
316056005429	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
316056005430	active site
316056005431	SAM binding site [chemical binding]; other site
316056005432	homodimer interface [polypeptide binding]; other site
316056005433	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
316056005434	active site
316056005435	SAM binding site [chemical binding]; other site
316056005436	homodimer interface [polypeptide binding]; other site
316056005437	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
316056005438	Precorrin-8X methylmutase; Region: CbiC; pfam02570
316056005439	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
316056005440	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
316056005441	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
316056005442	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
316056005443	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
316056005444	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
316056005445	CitB domain protein; Region: CitB; TIGR02484
316056005446	tricarballylate dehydrogenase; Validated; Region: PRK08274
316056005447	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
316056005448	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
316056005449	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
316056005450	active site
316056005451	SAM binding site [chemical binding]; other site
316056005452	homodimer interface [polypeptide binding]; other site
316056005453	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
316056005454	Protein of unknown function DUF72; Region: DUF72; pfam01904
316056005455	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
316056005456	Domain of unknown function (DUF892); Region: DUF892; pfam05974
316056005457	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056005458	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056005459	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056005460	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056005461	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
316056005462	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
316056005463	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056005464	active site
316056005465	phosphorylation site [posttranslational modification]
316056005466	intermolecular recognition site; other site
316056005467	dimerization interface [polypeptide binding]; other site
316056005468	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316056005469	DNA binding residues [nucleotide binding]
316056005470	dimerization interface [polypeptide binding]; other site
316056005471	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056005472	HAMP domain; Region: HAMP; pfam00672
316056005473	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056005474	ATP binding site [chemical binding]; other site
316056005475	Mg2+ binding site [ion binding]; other site
316056005476	G-X-G motif; other site
316056005477	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
316056005478	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
316056005479	Trp docking motif [polypeptide binding]; other site
316056005480	dimer interface [polypeptide binding]; other site
316056005481	active site
316056005482	small subunit binding site [polypeptide binding]; other site
316056005483	methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870
316056005484	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316056005485	substrate binding pocket [chemical binding]; other site
316056005486	membrane-bound complex binding site; other site
316056005487	hinge residues; other site
316056005488	cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872
316056005489	Methanol dehydrogenase beta subunit; Region: MDH; pfam02315
316056005490	MoxR-like ATPases [General function prediction only]; Region: COG0714
316056005491	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056005492	Walker A motif; other site
316056005493	ATP binding site [chemical binding]; other site
316056005494	Walker B motif; other site
316056005495	arginine finger; other site
316056005496	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
316056005497	metal ion-dependent adhesion site (MIDAS); other site
316056005498	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
316056005499	metal ion-dependent adhesion site (MIDAS); other site
316056005500	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
316056005501	putative hydrophobic ligand binding site [chemical binding]; other site
316056005502	protein interface [polypeptide binding]; other site
316056005503	gate; other site
316056005504	Methyltransferase domain; Region: Methyltransf_23; pfam13489
316056005505	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056005506	S-adenosylmethionine binding site [chemical binding]; other site
316056005507	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
316056005508	peroxiredoxin; Provisional; Region: PRK13189
316056005509	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
316056005510	dimer interface [polypeptide binding]; other site
316056005511	decamer (pentamer of dimers) interface [polypeptide binding]; other site
316056005512	catalytic triad [active]
316056005513	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
316056005514	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056005515	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056005516	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
316056005517	dimerization interface [polypeptide binding]; other site
316056005518	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
316056005519	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
316056005520	[2Fe-2S] cluster binding site [ion binding]; other site
316056005521	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
316056005522	active site
316056005523	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
316056005524	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
316056005525	classical (c) SDRs; Region: SDR_c; cd05233
316056005526	NAD(P) binding site [chemical binding]; other site
316056005527	active site
316056005528	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056005529	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
316056005530	Walker A/P-loop; other site
316056005531	ATP binding site [chemical binding]; other site
316056005532	Q-loop/lid; other site
316056005533	ABC transporter signature motif; other site
316056005534	Walker B; other site
316056005535	D-loop; other site
316056005536	H-loop/switch region; other site
316056005537	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
316056005538	FAD binding pocket [chemical binding]; other site
316056005539	FAD binding motif [chemical binding]; other site
316056005540	phosphate binding motif [ion binding]; other site
316056005541	beta-alpha-beta structure motif; other site
316056005542	NAD binding pocket [chemical binding]; other site
316056005543	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173
316056005544	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
316056005545	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
316056005546	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056005547	ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525
316056005548	Walker A/P-loop; other site
316056005549	ATP binding site [chemical binding]; other site
316056005550	Q-loop/lid; other site
316056005551	ABC transporter signature motif; other site
316056005552	Walker B; other site
316056005553	D-loop; other site
316056005554	H-loop/switch region; other site
316056005555	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
316056005556	Predicted permeases [General function prediction only]; Region: COG0701
316056005557	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316056005558	dimerization interface [polypeptide binding]; other site
316056005559	putative DNA binding site [nucleotide binding]; other site
316056005560	putative Zn2+ binding site [ion binding]; other site
316056005561	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
316056005562	active site residue [active]
316056005563	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
316056005564	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
316056005565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056005566	S-adenosylmethionine binding site [chemical binding]; other site
316056005567	BON domain; Region: BON; pfam04972
316056005568	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
316056005569	Mechanosensitive ion channel; Region: MS_channel; pfam00924
316056005570	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
316056005571	BA14K-like protein; Region: BA14K; pfam07886
316056005572	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
316056005573	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
316056005574	active site
316056005575	homotetramer interface [polypeptide binding]; other site
316056005576	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
316056005577	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
316056005578	putative ligand binding site [chemical binding]; other site
316056005579	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316056005580	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316056005581	TM-ABC transporter signature motif; other site
316056005582	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
316056005583	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316056005584	TM-ABC transporter signature motif; other site
316056005585	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
316056005586	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316056005587	Walker A/P-loop; other site
316056005588	ATP binding site [chemical binding]; other site
316056005589	Q-loop/lid; other site
316056005590	ABC transporter signature motif; other site
316056005591	Walker B; other site
316056005592	D-loop; other site
316056005593	H-loop/switch region; other site
316056005594	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
316056005595	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316056005596	Walker A/P-loop; other site
316056005597	ATP binding site [chemical binding]; other site
316056005598	Q-loop/lid; other site
316056005599	ABC transporter signature motif; other site
316056005600	Walker B; other site
316056005601	D-loop; other site
316056005602	H-loop/switch region; other site
316056005603	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
316056005604	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
316056005605	cobalt transport protein CbiM; Validated; Region: PRK06265
316056005606	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
316056005607	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
316056005608	nickel-responsive transcriptional regulator NikR; Region: nikR; TIGR02793
316056005609	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
316056005610	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
316056005611	Iron permease FTR1 family; Region: FTR1; cl00475
316056005612	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
316056005613	inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378
316056005614	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
316056005615	Imelysin; Region: Peptidase_M75; pfam09375
316056005616	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
316056005617	cobalt transport protein CbiM; Validated; Region: PRK06265
316056005618	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
316056005619	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
316056005620	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
316056005621	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
316056005622	Walker A/P-loop; other site
316056005623	ATP binding site [chemical binding]; other site
316056005624	Q-loop/lid; other site
316056005625	ABC transporter signature motif; other site
316056005626	Walker B; other site
316056005627	D-loop; other site
316056005628	H-loop/switch region; other site
316056005629	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
316056005630	GAF domain; Region: GAF; pfam01590
316056005631	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056005632	Walker A motif; other site
316056005633	ATP binding site [chemical binding]; other site
316056005634	Walker B motif; other site
316056005635	arginine finger; other site
316056005636	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316056005637	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
316056005638	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
316056005639	NAD(P) binding site [chemical binding]; other site
316056005640	catalytic residues [active]
316056005641	putative alcohol dehydrogenase; Provisional; Region: PRK09860
316056005642	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
316056005643	dimer interface [polypeptide binding]; other site
316056005644	active site
316056005645	metal binding site [ion binding]; metal-binding site
316056005646	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
316056005647	Transposase; Region: DEDD_Tnp_IS110; pfam01548
316056005648	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
316056005649	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
316056005650	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
316056005651	Walker A/P-loop; other site
316056005652	ATP binding site [chemical binding]; other site
316056005653	Q-loop/lid; other site
316056005654	ABC transporter signature motif; other site
316056005655	Walker B; other site
316056005656	D-loop; other site
316056005657	H-loop/switch region; other site
316056005658	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
316056005659	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
316056005660	ABC-ATPase subunit  interface; other site
316056005661	dimer interface [polypeptide binding]; other site
316056005662	putative PBP binding regions; other site
316056005663	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
316056005664	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
316056005665	putative hemin binding site; other site
316056005666	Hemin uptake protein hemP; Region: hemP; pfam10636
316056005667	coproporphyrinogen III oxidase; Provisional; Region: PRK09058
316056005668	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056005669	FeS/SAM binding site; other site
316056005670	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
316056005671	NADH(P)-binding; Region: NAD_binding_10; pfam13460
316056005672	NAD(P) binding site [chemical binding]; other site
316056005673	putative active site [active]
316056005674	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
316056005675	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316056005676	N-terminal plug; other site
316056005677	ligand-binding site [chemical binding]; other site
316056005678	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
316056005679	putative heme utilization carrier protein HutX; Region: HutX; TIGR04108
316056005680	Secretin and TonB N terminus short domain; Region: STN; smart00965
316056005681	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
316056005682	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316056005683	N-terminal plug; other site
316056005684	ligand-binding site [chemical binding]; other site
316056005685	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
316056005686	FecR protein; Region: FecR; pfam04773
316056005687	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316056005688	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
316056005689	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
316056005690	DNA binding residues [nucleotide binding]
316056005691	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
316056005692	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
316056005693	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
316056005694	TonB C terminal; Region: TonB_2; pfam13103
316056005695	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
316056005696	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316056005697	N-terminal plug; other site
316056005698	ligand-binding site [chemical binding]; other site
316056005699	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
316056005700	homodimer interaction site [polypeptide binding]; other site
316056005701	cofactor binding site; other site
316056005702	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
316056005703	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
316056005704	putative metal binding site [ion binding]; other site
316056005705	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
316056005706	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
316056005707	ABC-ATPase subunit  interface; other site
316056005708	dimer interface [polypeptide binding]; other site
316056005709	putative PBP binding regions; other site
316056005710	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
316056005711	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
316056005712	Walker A/P-loop; other site
316056005713	ATP binding site [chemical binding]; other site
316056005714	Q-loop/lid; other site
316056005715	ABC transporter signature motif; other site
316056005716	Walker B; other site
316056005717	D-loop; other site
316056005718	H-loop/switch region; other site
316056005719	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
316056005720	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
316056005721	TOBE domain; Region: TOBE; cl01440
316056005722	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
316056005723	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
316056005724	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056005725	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056005726	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
316056005727	Fusaric acid resistance protein family; Region: FUSC; pfam04632
316056005728	Cupin domain; Region: Cupin_2; pfam07883
316056005729	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
316056005730	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316056005731	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056005732	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056005733	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
316056005734	putative effector binding pocket; other site
316056005735	putative dimerization interface [polypeptide binding]; other site
316056005736	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056005737	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056005738	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
316056005739	NAD(P) binding site [chemical binding]; other site
316056005740	active site
316056005741	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
316056005742	dimer interaction site [polypeptide binding]; other site
316056005743	substrate-binding tunnel; other site
316056005744	active site
316056005745	catalytic site [active]
316056005746	substrate binding site [chemical binding]; other site
316056005747	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
316056005748	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
316056005749	NAD binding site [chemical binding]; other site
316056005750	homotetramer interface [polypeptide binding]; other site
316056005751	homodimer interface [polypeptide binding]; other site
316056005752	substrate binding site [chemical binding]; other site
316056005753	active site
316056005754	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056005755	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
316056005756	NAD(P) binding site [chemical binding]; other site
316056005757	active site
316056005758	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
316056005759	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
316056005760	Coenzyme A transferase; Region: CoA_trans; cl17247
316056005761	Coenzyme A transferase; Region: CoA_trans; cl17247
316056005762	putative acyltransferase; Provisional; Region: PRK05790
316056005763	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
316056005764	dimer interface [polypeptide binding]; other site
316056005765	active site
316056005766	Acetokinase family; Region: Acetate_kinase; cl17229
316056005767	propionate/acetate kinase; Provisional; Region: PRK12379
316056005768	phosphate acetyltransferase; Reviewed; Region: PRK05632
316056005769	DRTGG domain; Region: DRTGG; pfam07085
316056005770	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
316056005771	FOG: CBS domain [General function prediction only]; Region: COG0517
316056005772	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
316056005773	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
316056005774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056005775	Walker B motif; other site
316056005776	arginine finger; other site
316056005777	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316056005778	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
316056005779	Transposase; Region: DEDD_Tnp_IS110; pfam01548
316056005780	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
316056005781	flagellin; Reviewed; Region: PRK12688
316056005782	flagellin; Provisional; Region: PRK14708
316056005783	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
316056005784	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
316056005785	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
316056005786	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
316056005787	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
316056005788	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
316056005789	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
316056005790	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
316056005791	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316056005792	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316056005793	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056005794	active site
316056005795	phosphorylation site [posttranslational modification]
316056005796	intermolecular recognition site; other site
316056005797	dimerization interface [polypeptide binding]; other site
316056005798	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056005799	DNA binding site [nucleotide binding]
316056005800	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056005801	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056005802	dimer interface [polypeptide binding]; other site
316056005803	phosphorylation site [posttranslational modification]
316056005804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056005805	ATP binding site [chemical binding]; other site
316056005806	Mg2+ binding site [ion binding]; other site
316056005807	G-X-G motif; other site
316056005808	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
316056005809	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316056005810	DNA-binding site [nucleotide binding]; DNA binding site
316056005811	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316056005812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056005813	homodimer interface [polypeptide binding]; other site
316056005814	catalytic residue [active]
316056005815	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
316056005816	EamA-like transporter family; Region: EamA; pfam00892
316056005817	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
316056005818	hypothetical protein; Validated; Region: PRK07411
316056005819	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
316056005820	ATP binding site [chemical binding]; other site
316056005821	substrate interface [chemical binding]; other site
316056005822	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
316056005823	active site residue [active]
316056005824	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
316056005825	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
316056005826	dimer interface [polypeptide binding]; other site
316056005827	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056005828	catalytic residue [active]
316056005829	serine O-acetyltransferase; Region: cysE; TIGR01172
316056005830	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
316056005831	trimer interface [polypeptide binding]; other site
316056005832	active site
316056005833	substrate binding site [chemical binding]; other site
316056005834	CoA binding site [chemical binding]; other site
316056005835	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
316056005836	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
316056005837	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
316056005838	Autoinducer binding domain; Region: Autoind_bind; pfam03472
316056005839	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316056005840	DNA binding residues [nucleotide binding]
316056005841	dimerization interface [polypeptide binding]; other site
316056005842	Autoinducer synthetase; Region: Autoind_synth; cl17404
316056005843	peptide-modifying radical SAM enzyme CbpB; Region: rSAM_cobopep; TIGR04163
316056005844	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056005845	FeS/SAM binding site; other site
316056005846	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
316056005847	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
316056005848	putative acyl-acceptor binding pocket; other site
316056005849	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
316056005850	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
316056005851	active site
316056005852	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
316056005853	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
316056005854	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056005855	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
316056005856	Walker A/P-loop; other site
316056005857	ATP binding site [chemical binding]; other site
316056005858	ABC transporter signature motif; other site
316056005859	Walker B; other site
316056005860	D-loop; other site
316056005861	H-loop/switch region; other site
316056005862	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056005863	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056005864	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
316056005865	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
316056005866	Walker A/P-loop; other site
316056005867	ATP binding site [chemical binding]; other site
316056005868	Q-loop/lid; other site
316056005869	ABC transporter signature motif; other site
316056005870	Walker B; other site
316056005871	D-loop; other site
316056005872	H-loop/switch region; other site
316056005873	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
316056005874	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
316056005875	FtsX-like permease family; Region: FtsX; pfam02687
316056005876	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
316056005877	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
316056005878	DDE superfamily endonuclease; Region: DDE_3; pfam13358
316056005879	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
316056005880	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
316056005881	Homeodomain-like domain; Region: HTH_23; pfam13384
316056005882	Winged helix-turn helix; Region: HTH_29; pfam13551
316056005883	Winged helix-turn helix; Region: HTH_33; pfam13592
316056005884	Transposase; Region: HTH_Tnp_1; pfam01527
316056005885	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
316056005886	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
316056005887	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
316056005888	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
316056005889	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056005890	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056005891	acyl-activating enzyme (AAE) consensus motif; other site
316056005892	AMP binding site [chemical binding]; other site
316056005893	active site
316056005894	CoA binding site [chemical binding]; other site
316056005895	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
316056005896	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
316056005897	Ligand Binding Site [chemical binding]; other site
316056005898	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
316056005899	active site
316056005900	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
316056005901	dimer interface [polypeptide binding]; other site
316056005902	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
316056005903	Ligand Binding Site [chemical binding]; other site
316056005904	Molecular Tunnel; other site
316056005905	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
316056005906	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
316056005907	active site
316056005908	Condensation domain; Region: Condensation; pfam00668
316056005909	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316056005910	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
316056005911	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
316056005912	acyl-activating enzyme (AAE) consensus motif; other site
316056005913	AMP binding site [chemical binding]; other site
316056005914	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056005915	Condensation domain; Region: Condensation; pfam00668
316056005916	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316056005917	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
316056005918	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
316056005919	acyl-activating enzyme (AAE) consensus motif; other site
316056005920	AMP binding site [chemical binding]; other site
316056005921	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056005922	Condensation domain; Region: Condensation; pfam00668
316056005923	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316056005924	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
316056005925	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
316056005926	acyl-activating enzyme (AAE) consensus motif; other site
316056005927	AMP binding site [chemical binding]; other site
316056005928	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056005929	Condensation domain; Region: Condensation; pfam00668
316056005930	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316056005931	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
316056005932	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
316056005933	acyl-activating enzyme (AAE) consensus motif; other site
316056005934	AMP binding site [chemical binding]; other site
316056005935	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056005936	Condensation domain; Region: Condensation; pfam00668
316056005937	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316056005938	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
316056005939	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
316056005940	acyl-activating enzyme (AAE) consensus motif; other site
316056005941	AMP binding site [chemical binding]; other site
316056005942	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056005943	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
316056005944	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
316056005945	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
316056005946	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
316056005947	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
316056005948	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
316056005949	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
316056005950	FMN binding site [chemical binding]; other site
316056005951	active site
316056005952	catalytic residues [active]
316056005953	substrate binding site [chemical binding]; other site
316056005954	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
316056005955	Transposase; Region: DEDD_Tnp_IS110; pfam01548
316056005956	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
316056005957	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
316056005958	catalytic motif [active]
316056005959	Catalytic residue [active]
316056005960	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
316056005961	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056005962	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056005963	dimer interface [polypeptide binding]; other site
316056005964	phosphorylation site [posttranslational modification]
316056005965	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056005966	ATP binding site [chemical binding]; other site
316056005967	Mg2+ binding site [ion binding]; other site
316056005968	G-X-G motif; other site
316056005969	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
316056005970	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
316056005971	Domain of unknown function DUF59; Region: DUF59; cl00941
316056005972	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
316056005973	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
316056005974	Walker A motif; other site
316056005975	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
316056005976	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
316056005977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056005978	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316056005979	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056005980	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056005981	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
316056005982	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
316056005983	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
316056005984	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
316056005985	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
316056005986	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
316056005987	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
316056005988	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
316056005989	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056005990	FeS/SAM binding site; other site
316056005991	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
316056005992	phosphoglycolate phosphatase; Provisional; Region: PRK13222
316056005993	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
316056005994	active site
316056005995	motif I; other site
316056005996	motif II; other site
316056005997	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
316056005998	tetramer (dimer of dimers) interface [polypeptide binding]; other site
316056005999	active site
316056006000	dimer interface [polypeptide binding]; other site
316056006001	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
316056006002	glutathione reductase; Validated; Region: PRK06116
316056006003	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
316056006004	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316056006005	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
316056006006	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
316056006007	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
316056006008	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
316056006009	NAD synthetase; Provisional; Region: PRK13981
316056006010	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
316056006011	multimer interface [polypeptide binding]; other site
316056006012	active site
316056006013	catalytic triad [active]
316056006014	protein interface 1 [polypeptide binding]; other site
316056006015	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
316056006016	homodimer interface [polypeptide binding]; other site
316056006017	NAD binding pocket [chemical binding]; other site
316056006018	ATP binding pocket [chemical binding]; other site
316056006019	Mg binding site [ion binding]; other site
316056006020	active-site loop [active]
316056006021	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
316056006022	Domain of unknown function DUF20; Region: UPF0118; pfam01594
316056006023	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
316056006024	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
316056006025	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
316056006026	active site
316056006027	HIGH motif; other site
316056006028	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
316056006029	KMSKS motif; other site
316056006030	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
316056006031	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
316056006032	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
316056006033	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
316056006034	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
316056006035	active site
316056006036	catalytic residues [active]
316056006037	metal binding site [ion binding]; metal-binding site
316056006038	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
316056006039	hypothetical protein; Provisional; Region: PRK12474
316056006040	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
316056006041	PYR/PP interface [polypeptide binding]; other site
316056006042	dimer interface [polypeptide binding]; other site
316056006043	TPP binding site [chemical binding]; other site
316056006044	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
316056006045	TPP-binding site [chemical binding]; other site
316056006046	dimer interface [polypeptide binding]; other site
316056006047	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
316056006048	FAD binding domain; Region: FAD_binding_4; pfam01565
316056006049	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
316056006050	Transposase; Region: DEDD_Tnp_IS110; pfam01548
316056006051	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
316056006052	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
316056006053	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316056006054	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
316056006055	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
316056006056	Walker A/P-loop; other site
316056006057	ATP binding site [chemical binding]; other site
316056006058	Q-loop/lid; other site
316056006059	ABC transporter signature motif; other site
316056006060	Walker B; other site
316056006061	D-loop; other site
316056006062	H-loop/switch region; other site
316056006063	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
316056006064	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
316056006065	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
316056006066	CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009
316056006067	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
316056006068	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
316056006069	inhibitor-cofactor binding pocket; inhibition site
316056006070	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056006071	catalytic residue [active]
316056006072	AAA domain; Region: AAA_26; pfam13500
316056006073	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
316056006074	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
316056006075	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
316056006076	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316056006077	catalytic residue [active]
316056006078	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
316056006079	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
316056006080	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
316056006081	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
316056006082	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
316056006083	ligand binding site [chemical binding]; other site
316056006084	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
316056006085	potassium uptake protein; Region: kup; TIGR00794
316056006086	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
316056006087	active site residue [active]
316056006088	hypothetical protein; Provisional; Region: PRK08912
316056006089	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316056006090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056006091	homodimer interface [polypeptide binding]; other site
316056006092	catalytic residue [active]
316056006093	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
316056006094	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
316056006095	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
316056006096	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
316056006097	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
316056006098	putative acyl-acceptor binding pocket; other site
316056006099	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
316056006100	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
316056006101	NAD(P) binding site [chemical binding]; other site
316056006102	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
316056006103	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
316056006104	dimer interface [polypeptide binding]; other site
316056006105	active site
316056006106	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
316056006107	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
316056006108	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
316056006109	acyl carrier protein; Provisional; Region: PRK06508
316056006110	Inward rectifier potassium channel; Region: IRK; pfam01007
316056006111	MgtC family; Region: MgtC; pfam02308
316056006112	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
316056006113	PA26 p53-induced protein (sestrin); Region: PA26; pfam04636
316056006114	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
316056006115	HerA helicase [Replication, recombination, and repair]; Region: COG0433
316056006116	Domain of unknown function DUF87; Region: DUF87; pfam01935
316056006117	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
316056006118	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
316056006119	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056006120	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056006121	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056006122	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316056006123	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
316056006124	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056006125	Walker A motif; other site
316056006126	ATP binding site [chemical binding]; other site
316056006127	Walker B motif; other site
316056006128	arginine finger; other site
316056006129	PAS domain S-box; Region: sensory_box; TIGR00229
316056006130	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056006131	putative active site [active]
316056006132	heme pocket [chemical binding]; other site
316056006133	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056006134	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056006135	metal binding site [ion binding]; metal-binding site
316056006136	active site
316056006137	I-site; other site
316056006138	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
316056006139	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
316056006140	active site
316056006141	catalytic residue [active]
316056006142	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
316056006143	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
316056006144	active site residue [active]
316056006145	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
316056006146	active site residue [active]
316056006147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
316056006148	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316056006149	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
316056006150	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316056006151	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056006152	Walker A/P-loop; other site
316056006153	ATP binding site [chemical binding]; other site
316056006154	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316056006155	ABC transporter signature motif; other site
316056006156	ABC transporter; Region: ABC_tran_2; pfam12848
316056006157	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316056006158	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
316056006159	putative active site [active]
316056006160	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
316056006161	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
316056006162	Protein of unknown function (DUF3680); Region: DUF3680; pfam12441
316056006163	Protein of unknown function (DUF497); Region: DUF497; pfam04365
316056006164	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
316056006165	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056006166	S-adenosylmethionine binding site [chemical binding]; other site
316056006167	hypothetical protein; Provisional; Region: PRK05208
316056006168	Site-specific recombinase; Region: SpecificRecomb; cl15411
316056006169	lytic murein transglycosylase; Region: MltB_2; TIGR02283
316056006170	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316056006171	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316056006172	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
316056006173	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
316056006174	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
316056006175	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
316056006176	heme binding site [chemical binding]; other site
316056006177	ferroxidase pore; other site
316056006178	ferroxidase diiron center [ion binding]; other site
316056006179	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
316056006180	dihydrodipicolinate synthase; Region: dapA; TIGR00674
316056006181	dimer interface [polypeptide binding]; other site
316056006182	active site
316056006183	catalytic residue [active]
316056006184	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056006185	dimer interface [polypeptide binding]; other site
316056006186	putative CheW interface [polypeptide binding]; other site
316056006187	Predicted membrane protein [Function unknown]; Region: COG4270
316056006188	Hemerythrin; Region: Hemerythrin; cd12107
316056006189	Fe binding site [ion binding]; other site
316056006190	PAS domain S-box; Region: sensory_box; TIGR00229
316056006191	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056006192	putative active site [active]
316056006193	heme pocket [chemical binding]; other site
316056006194	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056006195	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056006196	metal binding site [ion binding]; metal-binding site
316056006197	active site
316056006198	I-site; other site
316056006199	Cupin domain; Region: Cupin_2; pfam07883
316056006200	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
316056006201	ThiC-associated domain; Region: ThiC-associated; pfam13667
316056006202	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
316056006203	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
316056006204	thiamine phosphate binding site [chemical binding]; other site
316056006205	active site
316056006206	pyrophosphate binding site [ion binding]; other site
316056006207	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
316056006208	ThiS interaction site; other site
316056006209	putative active site [active]
316056006210	tetramer interface [polypeptide binding]; other site
316056006211	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
316056006212	thiS-thiF/thiG interaction site; other site
316056006213	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
316056006214	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
316056006215	PRC-barrel domain; Region: PRC; pfam05239
316056006216	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
316056006217	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
316056006218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
316056006219	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316056006220	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
316056006221	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
316056006222	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
316056006223	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
316056006224	Autotransporter beta-domain; Region: Autotransporter; smart00869
316056006225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
316056006226	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
316056006227	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056006228	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056006229	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
316056006230	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
316056006231	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056006232	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056006233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056006234	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
316056006235	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056006236	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
316056006237	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316056006238	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056006239	Walker A/P-loop; other site
316056006240	ATP binding site [chemical binding]; other site
316056006241	Q-loop/lid; other site
316056006242	ABC transporter signature motif; other site
316056006243	Walker B; other site
316056006244	D-loop; other site
316056006245	H-loop/switch region; other site
316056006246	Cupin domain; Region: Cupin_2; pfam07883
316056006247	Ribulose bisphosphate carboxylase like proteins (RLPs) similar to R.rubrum RLP; Region: RLP_RrRLP; cd08210
316056006248	dimer interface [polypeptide binding]; other site
316056006249	active site
316056006250	catalytic residue [active]
316056006251	metal binding site [ion binding]; metal-binding site
316056006252	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
316056006253	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
316056006254	amidase catalytic site [active]
316056006255	Zn binding residues [ion binding]; other site
316056006256	substrate binding site [chemical binding]; other site
316056006257	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
316056006258	MraW methylase family; Region: Methyltransf_5; cl17771
316056006259	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
316056006260	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
316056006261	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
316056006262	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
316056006263	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
316056006264	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
316056006265	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
316056006266	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
316056006267	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
316056006268	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
316056006269	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
316056006270	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
316056006271	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
316056006272	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
316056006273	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
316056006274	Mg++ binding site [ion binding]; other site
316056006275	putative catalytic motif [active]
316056006276	putative substrate binding site [chemical binding]; other site
316056006277	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
316056006278	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
316056006279	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
316056006280	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056006281	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
316056006282	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
316056006283	acyl-activating enzyme (AAE) consensus motif; other site
316056006284	acyl-activating enzyme (AAE) consensus motif; other site
316056006285	putative AMP binding site [chemical binding]; other site
316056006286	putative active site [active]
316056006287	putative CoA binding site [chemical binding]; other site
316056006288	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
316056006289	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
316056006290	dimer interface [polypeptide binding]; other site
316056006291	active site
316056006292	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
316056006293	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056006294	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056006295	NAD(P) binding site [chemical binding]; other site
316056006296	active site
316056006297	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
316056006298	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
316056006299	active site
316056006300	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
316056006301	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
316056006302	FAD binding site [chemical binding]; other site
316056006303	substrate binding site [chemical binding]; other site
316056006304	catalytic base [active]
316056006305	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
316056006306	putative FMN binding site [chemical binding]; other site
316056006307	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
316056006308	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
316056006309	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
316056006310	enoyl-CoA hydratase; Provisional; Region: PRK07659
316056006311	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056006312	substrate binding site [chemical binding]; other site
316056006313	oxyanion hole (OAH) forming residues; other site
316056006314	trimer interface [polypeptide binding]; other site
316056006315	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056006316	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056006317	ligand binding site [chemical binding]; other site
316056006318	flexible hinge region; other site
316056006319	putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312
316056006320	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
316056006321	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
316056006322	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
316056006323	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
316056006324	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056006325	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056006326	metal binding site [ion binding]; metal-binding site
316056006327	active site
316056006328	I-site; other site
316056006329	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
316056006330	Autoinducer binding domain; Region: Autoind_bind; pfam03472
316056006331	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316056006332	DNA binding residues [nucleotide binding]
316056006333	dimerization interface [polypeptide binding]; other site
316056006334	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
316056006335	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
316056006336	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
316056006337	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056006338	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056006339	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
316056006340	putative effector binding pocket; other site
316056006341	putative dimerization interface [polypeptide binding]; other site
316056006342	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
316056006343	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
316056006344	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
316056006345	P-loop; other site
316056006346	Magnesium ion binding site [ion binding]; other site
316056006347	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
316056006348	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
316056006349	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056006350	dimer interface [polypeptide binding]; other site
316056006351	phosphorylation site [posttranslational modification]
316056006352	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056006353	ATP binding site [chemical binding]; other site
316056006354	Mg2+ binding site [ion binding]; other site
316056006355	G-X-G motif; other site
316056006356	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
316056006357	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056006358	active site
316056006359	phosphorylation site [posttranslational modification]
316056006360	intermolecular recognition site; other site
316056006361	dimerization interface [polypeptide binding]; other site
316056006362	Transcriptional regulator [Transcription]; Region: IclR; COG1414
316056006363	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
316056006364	Bacterial transcriptional regulator; Region: IclR; pfam01614
316056006365	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056006366	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
316056006367	substrate binding site [chemical binding]; other site
316056006368	oxyanion hole (OAH) forming residues; other site
316056006369	trimer interface [polypeptide binding]; other site
316056006370	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
316056006371	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
316056006372	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
316056006373	dicarboxylate--CoA ligase PimA; Region: pimA; TIGR03205
316056006374	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
316056006375	acyl-activating enzyme (AAE) consensus motif; other site
316056006376	putative AMP binding site [chemical binding]; other site
316056006377	putative active site [active]
316056006378	putative CoA binding site [chemical binding]; other site
316056006379	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
316056006380	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
316056006381	dimer interface [polypeptide binding]; other site
316056006382	active site
316056006383	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
316056006384	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
316056006385	active site
316056006386	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
316056006387	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
316056006388	active site
316056006389	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
316056006390	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
316056006391	N- and C-terminal domain interface [polypeptide binding]; other site
316056006392	active site
316056006393	MgATP binding site [chemical binding]; other site
316056006394	catalytic site [active]
316056006395	metal binding site [ion binding]; metal-binding site
316056006396	glycerol binding site [chemical binding]; other site
316056006397	homotetramer interface [polypeptide binding]; other site
316056006398	homodimer interface [polypeptide binding]; other site
316056006399	FBP binding site [chemical binding]; other site
316056006400	protein IIAGlc interface [polypeptide binding]; other site
316056006401	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
316056006402	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
316056006403	nudix motif; other site
316056006404	hypothetical protein; Provisional; Region: PRK05978
316056006405	ribonuclease R; Region: RNase_R; TIGR02063
316056006406	RNB domain; Region: RNB; pfam00773
316056006407	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
316056006408	RNA binding site [nucleotide binding]; other site
316056006409	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
316056006410	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
316056006411	active site
316056006412	interdomain interaction site; other site
316056006413	putative metal-binding site [ion binding]; other site
316056006414	nucleotide binding site [chemical binding]; other site
316056006415	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
316056006416	domain I; other site
316056006417	DNA binding groove [nucleotide binding]
316056006418	phosphate binding site [ion binding]; other site
316056006419	domain II; other site
316056006420	domain III; other site
316056006421	nucleotide binding site [chemical binding]; other site
316056006422	catalytic site [active]
316056006423	domain IV; other site
316056006424	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
316056006425	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
316056006426	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
316056006427	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
316056006428	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
316056006429	Predicted transcriptional regulators [Transcription]; Region: COG1733
316056006430	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
316056006431	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
316056006432	DNA protecting protein DprA; Region: dprA; TIGR00732
316056006433	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
316056006434	dihydroorotase; Validated; Region: PRK09059
316056006435	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
316056006436	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
316056006437	active site
316056006438	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
316056006439	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
316056006440	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
316056006441	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
316056006442	Protein of unknown function (DUF497); Region: DUF497; pfam04365
316056006443	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
316056006444	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_20; cd04679
316056006445	nudix motif; other site
316056006446	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
316056006447	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
316056006448	active site
316056006449	Protein required for attachment to host cells; Region: Host_attach; cl02398
316056006450	Predicted permeases [General function prediction only]; Region: COG0679
316056006451	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
316056006452	myosin-cross-reactive antigen; Provisional; Region: PRK13977
316056006453	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056006454	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056006455	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
316056006456	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
316056006457	FMN binding site [chemical binding]; other site
316056006458	substrate binding site [chemical binding]; other site
316056006459	putative catalytic residue [active]
316056006460	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
316056006461	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
316056006462	Protein of unknown function (DUF497); Region: DUF497; pfam04365
316056006463	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
316056006464	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
316056006465	PAS fold; Region: PAS_4; pfam08448
316056006466	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
316056006467	putative active site [active]
316056006468	heme pocket [chemical binding]; other site
316056006469	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
316056006470	Histidine kinase; Region: HisKA_2; pfam07568
316056006471	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056006472	ATP binding site [chemical binding]; other site
316056006473	Mg2+ binding site [ion binding]; other site
316056006474	G-X-G motif; other site
316056006475	Patatin-like phospholipase; Region: Patatin; pfam01734
316056006476	active site
316056006477	nucleophile elbow; other site
316056006478	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
316056006479	putative active site [active]
316056006480	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
316056006481	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
316056006482	GatB domain; Region: GatB_Yqey; smart00845
316056006483	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
316056006484	Sel1 repeat; Region: Sel1; cl02723
316056006485	Cache domain; Region: Cache_2; cl07034
316056006486	NnrU protein; Region: NnrU; pfam07298
316056006487	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
316056006488	oligomerization interface [polypeptide binding]; other site
316056006489	active site
316056006490	metal binding site [ion binding]; metal-binding site
316056006491	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
316056006492	GTP-binding protein Der; Reviewed; Region: PRK00093
316056006493	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
316056006494	G1 box; other site
316056006495	GTP/Mg2+ binding site [chemical binding]; other site
316056006496	Switch I region; other site
316056006497	G2 box; other site
316056006498	Switch II region; other site
316056006499	G3 box; other site
316056006500	G4 box; other site
316056006501	G5 box; other site
316056006502	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
316056006503	G1 box; other site
316056006504	GTP/Mg2+ binding site [chemical binding]; other site
316056006505	Switch I region; other site
316056006506	G2 box; other site
316056006507	G3 box; other site
316056006508	Switch II region; other site
316056006509	G4 box; other site
316056006510	G5 box; other site
316056006511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056006512	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316056006513	putative substrate translocation pore; other site
316056006514	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
316056006515	classical (c) SDRs; Region: SDR_c; cd05233
316056006516	NAD(P) binding site [chemical binding]; other site
316056006517	active site
316056006518	amidophosphoribosyltransferase; Provisional; Region: PRK09123
316056006519	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
316056006520	active site
316056006521	tetramer interface [polypeptide binding]; other site
316056006522	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
316056006523	active site
316056006524	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
316056006525	Colicin V production protein; Region: Colicin_V; pfam02674
316056006526	DNA repair protein RadA; Provisional; Region: PRK11823
316056006527	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
316056006528	Walker A motif; other site
316056006529	ATP binding site [chemical binding]; other site
316056006530	Walker B motif; other site
316056006531	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
316056006532	Uncharacterized conserved protein [Function unknown]; Region: COG5470
316056006533	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
316056006534	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
316056006535	GAF domain; Region: GAF_3; pfam13492
316056006536	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
316056006537	Histidine kinase; Region: HisKA_2; pfam07568
316056006538	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056006539	ATP binding site [chemical binding]; other site
316056006540	Mg2+ binding site [ion binding]; other site
316056006541	G-X-G motif; other site
316056006542	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
316056006543	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
316056006544	active site
316056006545	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
316056006546	dimer interface [polypeptide binding]; other site
316056006547	substrate binding site [chemical binding]; other site
316056006548	catalytic residues [active]
316056006549	replicative DNA helicase; Provisional; Region: PRK09165
316056006550	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
316056006551	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
316056006552	Walker A motif; other site
316056006553	ATP binding site [chemical binding]; other site
316056006554	Walker B motif; other site
316056006555	DNA binding loops [nucleotide binding]
316056006556	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
316056006557	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056006558	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
316056006559	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
316056006560	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
316056006561	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
316056006562	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
316056006563	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
316056006564	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
316056006565	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
316056006566	ethanolamine permease; Region: 2A0305; TIGR00908
316056006567	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
316056006568	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056006569	NAD(P) binding site [chemical binding]; other site
316056006570	active site
316056006571	acyl carrier protein; Provisional; Region: acpP; PRK00982
316056006572	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
316056006573	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
316056006574	dimer interface [polypeptide binding]; other site
316056006575	active site
316056006576	YceG-like family; Region: YceG; pfam02618
316056006577	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
316056006578	dimerization interface [polypeptide binding]; other site
316056006579	hypothetical protein; Provisional; Region: PRK11820
316056006580	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
316056006581	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
316056006582	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
316056006583	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
316056006584	catalytic site [active]
316056006585	G-X2-G-X-G-K; other site
316056006586	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
316056006587	6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240
316056006588	putative NAD(P) binding site [chemical binding]; other site
316056006589	catalytic Zn binding site [ion binding]; other site
316056006590	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
316056006591	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
316056006592	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
316056006593	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
316056006594	SurA N-terminal domain; Region: SurA_N; pfam09312
316056006595	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
316056006596	OstA-like protein; Region: OstA; cl00844
316056006597	Organic solvent tolerance protein; Region: OstA_C; pfam04453
316056006598	Predicted permeases [General function prediction only]; Region: COG0795
316056006599	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
316056006600	Predicted permeases [General function prediction only]; Region: COG0795
316056006601	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
316056006602	multifunctional aminopeptidase A; Provisional; Region: PRK00913
316056006603	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
316056006604	interface (dimer of trimers) [polypeptide binding]; other site
316056006605	Substrate-binding/catalytic site; other site
316056006606	Zn-binding sites [ion binding]; other site
316056006607	DNA polymerase III subunit chi; Validated; Region: PRK05728
316056006608	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
316056006609	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316056006610	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316056006611	ABC transporter; Region: ABC_tran_2; pfam12848
316056006612	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316056006613	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
316056006614	active site
316056006615	multimer interface [polypeptide binding]; other site
316056006616	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
316056006617	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
316056006618	DNA-binding site [nucleotide binding]; DNA binding site
316056006619	RNA-binding motif; other site
316056006620	Uncharacterized conserved protein [Function unknown]; Region: COG2353
316056006621	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
316056006622	Uncharacterized conserved protein [Function unknown]; Region: COG2353
316056006623	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056006624	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056006625	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316056006626	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
316056006627	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
316056006628	active site
316056006629	substrate binding site [chemical binding]; other site
316056006630	cosubstrate binding site; other site
316056006631	catalytic site [active]
316056006632	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
316056006633	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
316056006634	dimerization interface [polypeptide binding]; other site
316056006635	putative ATP binding site [chemical binding]; other site
316056006636	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
316056006637	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
316056006638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
316056006639	polyphosphate kinase; Provisional; Region: PRK05443
316056006640	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
316056006641	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
316056006642	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
316056006643	putative domain interface [polypeptide binding]; other site
316056006644	putative active site [active]
316056006645	catalytic site [active]
316056006646	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
316056006647	putative domain interface [polypeptide binding]; other site
316056006648	putative active site [active]
316056006649	catalytic site [active]
316056006650	exopolyphosphatase; Region: exo_poly_only; TIGR03706
316056006651	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
316056006652	Predicted transcriptional regulator [Transcription]; Region: COG3905
316056006653	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
316056006654	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
316056006655	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
316056006656	catalytic site [active]
316056006657	putative active site [active]
316056006658	putative substrate binding site [chemical binding]; other site
316056006659	HRDC domain; Region: HRDC; pfam00570
316056006660	hypothetical protein; Validated; Region: PRK00029
316056006661	Uncharacterized conserved protein [Function unknown]; Region: COG0397
316056006662	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
316056006663	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
316056006664	dimer interface [polypeptide binding]; other site
316056006665	anticodon binding site; other site
316056006666	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
316056006667	motif 1; other site
316056006668	dimer interface [polypeptide binding]; other site
316056006669	active site
316056006670	motif 2; other site
316056006671	GAD domain; Region: GAD; pfam02938
316056006672	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
316056006673	active site
316056006674	motif 3; other site
316056006675	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
316056006676	Malic enzyme, N-terminal domain; Region: malic; pfam00390
316056006677	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
316056006678	putative NAD(P) binding site [chemical binding]; other site
316056006679	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
316056006680	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
316056006681	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056006682	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316056006683	dimerization interface [polypeptide binding]; other site
316056006684	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
316056006685	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
316056006686	PBP superfamily domain; Region: PBP_like_2; cl17296
316056006687	Predicted membrane protein [Function unknown]; Region: COG2259
316056006688	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
316056006689	folate binding site [chemical binding]; other site
316056006690	NADP+ binding site [chemical binding]; other site
316056006691	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
316056006692	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
316056006693	NodB motif; other site
316056006694	active site
316056006695	catalytic site [active]
316056006696	metal binding site [ion binding]; metal-binding site
316056006697	hypothetical protein; Provisional; Region: PRK06132
316056006698	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316056006699	CreA protein; Region: CreA; pfam05981
316056006700	Histidine kinase; Region: HisKA_2; pfam07568
316056006701	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
316056006702	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056006703	ATP binding site [chemical binding]; other site
316056006704	Mg2+ binding site [ion binding]; other site
316056006705	G-X-G motif; other site
316056006706	acetylornithine deacetylase; Provisional; Region: PRK06837
316056006707	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
316056006708	metal binding site [ion binding]; metal-binding site
316056006709	dimer interface [polypeptide binding]; other site
316056006710	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
316056006711	CoenzymeA binding site [chemical binding]; other site
316056006712	subunit interaction site [polypeptide binding]; other site
316056006713	PHB binding site; other site
316056006714	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056006715	Coenzyme A binding pocket [chemical binding]; other site
316056006716	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
316056006717	Sel1-like repeats; Region: SEL1; smart00671
316056006718	Sel1-like repeats; Region: SEL1; smart00671
316056006719	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
316056006720	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
316056006721	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
316056006722	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
316056006723	CAAX protease self-immunity; Region: Abi; pfam02517
316056006724	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
316056006725	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
316056006726	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316056006727	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
316056006728	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316056006729	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
316056006730	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
316056006731	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316056006732	Walker A/P-loop; other site
316056006733	ATP binding site [chemical binding]; other site
316056006734	Q-loop/lid; other site
316056006735	ABC transporter signature motif; other site
316056006736	Walker B; other site
316056006737	D-loop; other site
316056006738	H-loop/switch region; other site
316056006739	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
316056006740	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316056006741	Walker A/P-loop; other site
316056006742	ATP binding site [chemical binding]; other site
316056006743	Q-loop/lid; other site
316056006744	ABC transporter signature motif; other site
316056006745	Walker B; other site
316056006746	D-loop; other site
316056006747	H-loop/switch region; other site
316056006748	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
316056006749	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056006750	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056006751	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056006752	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056006753	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
316056006754	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
316056006755	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
316056006756	Restriction endonuclease; Region: Mrr_cat; pfam04471
316056006757	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
316056006758	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
316056006759	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
316056006760	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
316056006761	active site
316056006762	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
316056006763	TSCPD domain; Region: TSCPD; pfam12637
316056006764	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
316056006765	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
316056006766	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
316056006767	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
316056006768	EamA-like transporter family; Region: EamA; pfam00892
316056006769	EamA-like transporter family; Region: EamA; pfam00892
316056006770	glutamine synthetase; Provisional; Region: glnA; PRK09469
316056006771	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
316056006772	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
316056006773	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
316056006774	Nitrogen regulatory protein P-II; Region: P-II; smart00938
316056006775	Uncharacterized conserved protein [Function unknown]; Region: COG0062
316056006776	putative carbohydrate kinase; Provisional; Region: PRK10565
316056006777	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
316056006778	putative substrate binding site [chemical binding]; other site
316056006779	putative ATP binding site [chemical binding]; other site
316056006780	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
316056006781	Multicopper oxidase; Region: Cu-oxidase; pfam00394
316056006782	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
316056006783	trigger factor; Provisional; Region: tig; PRK01490
316056006784	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
316056006785	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
316056006786	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
316056006787	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
316056006788	oligomer interface [polypeptide binding]; other site
316056006789	active site residues [active]
316056006790	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
316056006791	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
316056006792	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056006793	Walker A motif; other site
316056006794	ATP binding site [chemical binding]; other site
316056006795	Walker B motif; other site
316056006796	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
316056006797	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
316056006798	Found in ATP-dependent protease La (LON); Region: LON; smart00464
316056006799	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056006800	Walker A motif; other site
316056006801	ATP binding site [chemical binding]; other site
316056006802	Walker B motif; other site
316056006803	arginine finger; other site
316056006804	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
316056006805	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
316056006806	peptidase T; Region: peptidase-T; TIGR01882
316056006807	metal binding site [ion binding]; metal-binding site
316056006808	dimer interface [polypeptide binding]; other site
316056006809	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
316056006810	IHF - DNA interface [nucleotide binding]; other site
316056006811	IHF dimer interface [polypeptide binding]; other site
316056006812	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
316056006813	NADH dehydrogenase subunit B; Validated; Region: PRK06411
316056006814	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
316056006815	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
316056006816	hypothetical protein; Reviewed; Region: PRK12275
316056006817	four helix bundle protein; Region: TIGR02436
316056006818	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
316056006819	NADH dehydrogenase subunit D; Validated; Region: PRK06075
316056006820	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
316056006821	NADH dehydrogenase subunit E; Validated; Region: PRK07539
316056006822	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
316056006823	putative dimer interface [polypeptide binding]; other site
316056006824	[2Fe-2S] cluster binding site [ion binding]; other site
316056006825	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
316056006826	SLBB domain; Region: SLBB; pfam10531
316056006827	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
316056006828	NADH dehydrogenase subunit G; Validated; Region: PRK09130
316056006829	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316056006830	catalytic loop [active]
316056006831	iron binding site [ion binding]; other site
316056006832	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
316056006833	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
316056006834	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
316056006835	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
316056006836	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
316056006837	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
316056006838	4Fe-4S binding domain; Region: Fer4; pfam00037
316056006839	4Fe-4S binding domain; Region: Fer4; pfam00037
316056006840	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
316056006841	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
316056006842	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
316056006843	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
316056006844	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
316056006845	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056006846	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
316056006847	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056006848	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
316056006849	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056006850	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
316056006851	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
316056006852	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
316056006853	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
316056006854	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
316056006855	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
316056006856	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
316056006857	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
316056006858	dimer interface [polypeptide binding]; other site
316056006859	substrate binding site [chemical binding]; other site
316056006860	metal binding site [ion binding]; metal-binding site
316056006861	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
316056006862	Protein of unknown function (DUF461); Region: DUF461; pfam04314
316056006863	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
316056006864	CopC domain; Region: CopC; pfam04234
316056006865	Copper resistance protein D; Region: CopD; cl00563
316056006866	prolyl-tRNA synthetase; Provisional; Region: PRK12325
316056006867	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
316056006868	dimer interface [polypeptide binding]; other site
316056006869	motif 1; other site
316056006870	active site
316056006871	motif 2; other site
316056006872	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
316056006873	active site
316056006874	motif 3; other site
316056006875	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
316056006876	anticodon binding site; other site
316056006877	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
316056006878	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
316056006879	FtsX-like permease family; Region: FtsX; pfam02687
316056006880	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
316056006881	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
316056006882	Walker A/P-loop; other site
316056006883	ATP binding site [chemical binding]; other site
316056006884	Q-loop/lid; other site
316056006885	ABC transporter signature motif; other site
316056006886	Walker B; other site
316056006887	D-loop; other site
316056006888	H-loop/switch region; other site
316056006889	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
316056006890	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
316056006891	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
316056006892	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
316056006893	putative active site [active]
316056006894	putative PHP Thumb interface [polypeptide binding]; other site
316056006895	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
316056006896	generic binding surface I; other site
316056006897	generic binding surface II; other site
316056006898	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
316056006899	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
316056006900	putative active site [active]
316056006901	30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311
316056006902	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
316056006903	rRNA interaction site [nucleotide binding]; other site
316056006904	S8 interaction site; other site
316056006905	putative laminin-1 binding site; other site
316056006906	Uncharacterized conserved protein [Function unknown]; Region: COG3743
316056006907	elongation factor Ts; Provisional; Region: tsf; PRK09377
316056006908	UBA/TS-N domain; Region: UBA; pfam00627
316056006909	Elongation factor TS; Region: EF_TS; pfam00889
316056006910	Elongation factor TS; Region: EF_TS; pfam00889
316056006911	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
316056006912	putative nucleotide binding site [chemical binding]; other site
316056006913	uridine monophosphate binding site [chemical binding]; other site
316056006914	homohexameric interface [polypeptide binding]; other site
316056006915	ribosome recycling factor; Reviewed; Region: frr; PRK00083
316056006916	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
316056006917	hinge region; other site
316056006918	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
316056006919	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
316056006920	catalytic residue [active]
316056006921	putative FPP diphosphate  binding site; other site
316056006922	putative FPP binding hydrophobic cleft; other site
316056006923	dimer interface [polypeptide binding]; other site
316056006924	putative IPP diphosphate binding site; other site
316056006925	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
316056006926	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
316056006927	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
316056006928	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
316056006929	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
316056006930	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
316056006931	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
316056006932	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
316056006933	active site
316056006934	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
316056006935	protein binding site [polypeptide binding]; other site
316056006936	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
316056006937	putative substrate binding region [chemical binding]; other site
316056006938	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
316056006939	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
316056006940	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
316056006941	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
316056006942	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
316056006943	Surface antigen; Region: Bac_surface_Ag; pfam01103
316056006944	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
316056006945	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
316056006946	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
316056006947	trimer interface [polypeptide binding]; other site
316056006948	active site
316056006949	UDP-GlcNAc binding site [chemical binding]; other site
316056006950	lipid binding site [chemical binding]; lipid-binding site
316056006951	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
316056006952	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
316056006953	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
316056006954	active site
316056006955	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
316056006956	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
316056006957	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
316056006958	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
316056006959	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
316056006960	dimer interface [polypeptide binding]; other site
316056006961	active site
316056006962	citrylCoA binding site [chemical binding]; other site
316056006963	NADH binding [chemical binding]; other site
316056006964	cationic pore residues; other site
316056006965	oxalacetate/citrate binding site [chemical binding]; other site
316056006966	coenzyme A binding site [chemical binding]; other site
316056006967	catalytic triad [active]
316056006968	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
316056006969	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
316056006970	active site
316056006971	HIGH motif; other site
316056006972	nucleotide binding site [chemical binding]; other site
316056006973	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
316056006974	active site
316056006975	KMSKS motif; other site
316056006976	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
316056006977	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
316056006978	active site
316056006979	HIGH motif; other site
316056006980	nucleotide binding site [chemical binding]; other site
316056006981	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
316056006982	KMSKS motif; other site
316056006983	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
316056006984	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
316056006985	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
316056006986	Competence protein; Region: Competence; pfam03772
316056006987	LexA repressor; Validated; Region: PRK00215
316056006988	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
316056006989	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
316056006990	Catalytic site [active]
316056006991	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
316056006992	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
316056006993	dimer interface [polypeptide binding]; other site
316056006994	putative functional site; other site
316056006995	putative MPT binding site; other site
316056006996	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056006997	dimerization interface [polypeptide binding]; other site
316056006998	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056006999	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056007000	dimer interface [polypeptide binding]; other site
316056007001	putative CheW interface [polypeptide binding]; other site
316056007002	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
316056007003	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
316056007004	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
316056007005	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
316056007006	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
316056007007	ligand binding site [chemical binding]; other site
316056007008	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
316056007009	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
316056007010	putative ligand binding site [chemical binding]; other site
316056007011	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
316056007012	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
316056007013	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
316056007014	Soluble P-type ATPase [General function prediction only]; Region: COG4087
316056007015	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
316056007016	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
316056007017	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
316056007018	putative dimer interface [polypeptide binding]; other site
316056007019	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
316056007020	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
316056007021	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
316056007022	trimer interface [polypeptide binding]; other site
316056007023	active site
316056007024	UDP-GlcNAc binding site [chemical binding]; other site
316056007025	lipid binding site [chemical binding]; lipid-binding site
316056007026	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
316056007027	trimer interface [polypeptide binding]; other site
316056007028	dimer interface [polypeptide binding]; other site
316056007029	putative active site [active]
316056007030	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
316056007031	active site
316056007032	ribulose/triose binding site [chemical binding]; other site
316056007033	phosphate binding site [ion binding]; other site
316056007034	substrate (anthranilate) binding pocket [chemical binding]; other site
316056007035	product (indole) binding pocket [chemical binding]; other site
316056007036	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
316056007037	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
316056007038	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
316056007039	SurA N-terminal domain; Region: SurA_N_3; cl07813
316056007040	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
316056007041	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
316056007042	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
316056007043	triosephosphate isomerase; Provisional; Region: PRK14565
316056007044	substrate binding site [chemical binding]; other site
316056007045	dimer interface [polypeptide binding]; other site
316056007046	catalytic triad [active]
316056007047	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
316056007048	CTP synthetase; Validated; Region: pyrG; PRK05380
316056007049	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
316056007050	Catalytic site [active]
316056007051	active site
316056007052	UTP binding site [chemical binding]; other site
316056007053	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
316056007054	active site
316056007055	putative oxyanion hole; other site
316056007056	catalytic triad [active]
316056007057	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
316056007058	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
316056007059	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
316056007060	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
316056007061	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
316056007062	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
316056007063	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
316056007064	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
316056007065	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
316056007066	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
316056007067	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056007068	putative substrate translocation pore; other site
316056007069	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
316056007070	DNA binding residues [nucleotide binding]
316056007071	GAF domain; Region: GAF; pfam01590
316056007072	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
316056007073	choline dehydrogenase; Validated; Region: PRK02106
316056007074	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
316056007075	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
316056007076	enolase; Provisional; Region: eno; PRK00077
316056007077	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
316056007078	dimer interface [polypeptide binding]; other site
316056007079	metal binding site [ion binding]; metal-binding site
316056007080	substrate binding pocket [chemical binding]; other site
316056007081	2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291
316056007082	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
316056007083	NADP binding site [chemical binding]; other site
316056007084	dimer interface [polypeptide binding]; other site
316056007085	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
316056007086	metallophosphoesterase, RPA4764 family; Region: RPA4764; TIGR03768
316056007087	Predicted flavoprotein [General function prediction only]; Region: COG0431
316056007088	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
316056007089	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
316056007090	Septum formation initiator; Region: DivIC; pfam04977
316056007091	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
316056007092	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
316056007093	tetramer interface [polypeptide binding]; other site
316056007094	TPP-binding site [chemical binding]; other site
316056007095	heterodimer interface [polypeptide binding]; other site
316056007096	phosphorylation loop region [posttranslational modification]
316056007097	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
316056007098	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
316056007099	E3 interaction surface; other site
316056007100	lipoyl attachment site [posttranslational modification]; other site
316056007101	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
316056007102	alpha subunit interface [polypeptide binding]; other site
316056007103	TPP binding site [chemical binding]; other site
316056007104	heterodimer interface [polypeptide binding]; other site
316056007105	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
316056007106	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
316056007107	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
316056007108	E3 interaction surface; other site
316056007109	lipoyl attachment site [posttranslational modification]; other site
316056007110	e3 binding domain; Region: E3_binding; pfam02817
316056007111	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
316056007112	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
316056007113	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
316056007114	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316056007115	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
316056007116	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
316056007117	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
316056007118	Sel1-like repeats; Region: SEL1; smart00671
316056007119	Sel1-like repeats; Region: SEL1; smart00671
316056007120	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
316056007121	putative catalytic site [active]
316056007122	putative phosphate binding site [ion binding]; other site
316056007123	active site
316056007124	metal binding site A [ion binding]; metal-binding site
316056007125	DNA binding site [nucleotide binding]
316056007126	putative AP binding site [nucleotide binding]; other site
316056007127	putative metal binding site B [ion binding]; other site
316056007128	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056007129	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056007130	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056007131	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
316056007132	Protein of unknown function (DUF433); Region: DUF433; pfam04255
316056007133	Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931
316056007134	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
316056007135	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
316056007136	catalytic core [active]
316056007137	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
316056007138	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
316056007139	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
316056007140	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
316056007141	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
316056007142	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
316056007143	active site
316056007144	HIGH motif; other site
316056007145	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
316056007146	KMSK motif region; other site
316056007147	tRNA binding surface [nucleotide binding]; other site
316056007148	DALR anticodon binding domain; Region: DALR_1; smart00836
316056007149	anticodon binding site; other site
316056007150	Sporulation related domain; Region: SPOR; pfam05036
316056007151	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
316056007152	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
316056007153	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
316056007154	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
316056007155	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
316056007156	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
316056007157	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
316056007158	seryl-tRNA synthetase; Provisional; Region: PRK05431
316056007159	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
316056007160	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
316056007161	dimer interface [polypeptide binding]; other site
316056007162	active site
316056007163	motif 1; other site
316056007164	motif 2; other site
316056007165	motif 3; other site
316056007166	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
316056007167	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
316056007168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056007169	active site
316056007170	phosphorylation site [posttranslational modification]
316056007171	intermolecular recognition site; other site
316056007172	dimerization interface [polypeptide binding]; other site
316056007173	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
316056007174	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056007175	S-adenosylmethionine binding site [chemical binding]; other site
316056007176	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
316056007177	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
316056007178	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
316056007179	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
316056007180	Peptidase family M23; Region: Peptidase_M23; pfam01551
316056007181	Uncharacterized conserved protein [Function unknown]; Region: COG3339
316056007182	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
316056007183	aromatic arch; other site
316056007184	DCoH dimer interaction site [polypeptide binding]; other site
316056007185	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
316056007186	DCoH tetramer interaction site [polypeptide binding]; other site
316056007187	substrate binding site [chemical binding]; other site
316056007188	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
316056007189	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
316056007190	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
316056007191	G1 box; other site
316056007192	putative GEF interaction site [polypeptide binding]; other site
316056007193	GTP/Mg2+ binding site [chemical binding]; other site
316056007194	Switch I region; other site
316056007195	G2 box; other site
316056007196	G3 box; other site
316056007197	Switch II region; other site
316056007198	G4 box; other site
316056007199	G5 box; other site
316056007200	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
316056007201	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
316056007202	DctM-like transporters; Region: DctM; pfam06808
316056007203	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
316056007204	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
316056007205	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
316056007206	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
316056007207	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
316056007208	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
316056007209	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056007210	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056007211	ligand binding site [chemical binding]; other site
316056007212	flexible hinge region; other site
316056007213	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
316056007214	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
316056007215	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
316056007216	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
316056007217	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056007218	Coenzyme A binding pocket [chemical binding]; other site
316056007219	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
316056007220	MG2 domain; Region: A2M_N; pfam01835
316056007221	Alpha-2-macroglobulin family; Region: A2M; pfam00207
316056007222	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
316056007223	surface patch; other site
316056007224	thioester region; other site
316056007225	specificity defining residues; other site
316056007226	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
316056007227	Transglycosylase; Region: Transgly; pfam00912
316056007228	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
316056007229	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
316056007230	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
316056007231	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
316056007232	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
316056007233	active site
316056007234	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
316056007235	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
316056007236	Ligand binding site; other site
316056007237	Putative Catalytic site; other site
316056007238	DXD motif; other site
316056007239	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
316056007240	cystathionine beta-lyase; Provisional; Region: PRK05967
316056007241	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
316056007242	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316056007243	catalytic residue [active]
316056007244	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
316056007245	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316056007246	substrate binding pocket [chemical binding]; other site
316056007247	membrane-bound complex binding site; other site
316056007248	hinge residues; other site
316056007249	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
316056007250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
316056007251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
316056007252	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056007253	dimer interface [polypeptide binding]; other site
316056007254	conserved gate region; other site
316056007255	putative PBP binding loops; other site
316056007256	ABC-ATPase subunit interface; other site
316056007257	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
316056007258	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
316056007259	Walker A/P-loop; other site
316056007260	ATP binding site [chemical binding]; other site
316056007261	Q-loop/lid; other site
316056007262	ABC transporter signature motif; other site
316056007263	Walker B; other site
316056007264	D-loop; other site
316056007265	H-loop/switch region; other site
316056007266	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
316056007267	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
316056007268	dimer interface [polypeptide binding]; other site
316056007269	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056007270	catalytic residue [active]
316056007271	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
316056007272	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
316056007273	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056007274	S-adenosylmethionine binding site [chemical binding]; other site
316056007275	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
316056007276	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
316056007277	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
316056007278	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
316056007279	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056007280	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056007281	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056007282	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
316056007283	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
316056007284	Protein export membrane protein; Region: SecD_SecF; cl14618
316056007285	DTW domain; Region: DTW; cl01221
316056007286	Sensors of blue-light using FAD; Region: BLUF; pfam04940
316056007287	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
316056007288	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056007289	S-adenosylmethionine binding site [chemical binding]; other site
316056007290	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
316056007291	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
316056007292	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
316056007293	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
316056007294	HIGH motif; other site
316056007295	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
316056007296	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
316056007297	active site
316056007298	KMSKS motif; other site
316056007299	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
316056007300	tRNA binding surface [nucleotide binding]; other site
316056007301	anticodon binding site; other site
316056007302	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
316056007303	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
316056007304	DNA binding site [nucleotide binding]
316056007305	active site
316056007306	lipoyl synthase; Provisional; Region: PRK05481
316056007307	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056007308	FeS/SAM binding site; other site
316056007309	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
316056007310	putative coenzyme Q binding site [chemical binding]; other site
316056007311	Competence-damaged protein; Region: CinA; pfam02464
316056007312	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
316056007313	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
316056007314	substrate binding site; other site
316056007315	dimer interface; other site
316056007316	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
316056007317	homotrimer interaction site [polypeptide binding]; other site
316056007318	zinc binding site [ion binding]; other site
316056007319	CDP-binding sites; other site
316056007320	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
316056007321	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
316056007322	FMN binding site [chemical binding]; other site
316056007323	active site
316056007324	catalytic residues [active]
316056007325	substrate binding site [chemical binding]; other site
316056007326	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
316056007327	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056007328	putative active site [active]
316056007329	heme pocket [chemical binding]; other site
316056007330	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056007331	dimer interface [polypeptide binding]; other site
316056007332	phosphorylation site [posttranslational modification]
316056007333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056007334	ATP binding site [chemical binding]; other site
316056007335	Mg2+ binding site [ion binding]; other site
316056007336	G-X-G motif; other site
316056007337	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
316056007338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056007339	active site
316056007340	phosphorylation site [posttranslational modification]
316056007341	intermolecular recognition site; other site
316056007342	dimerization interface [polypeptide binding]; other site
316056007343	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056007344	Walker A motif; other site
316056007345	ATP binding site [chemical binding]; other site
316056007346	Walker B motif; other site
316056007347	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
316056007348	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
316056007349	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056007350	dimerization interface [polypeptide binding]; other site
316056007351	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056007352	putative active site [active]
316056007353	heme pocket [chemical binding]; other site
316056007354	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056007355	dimer interface [polypeptide binding]; other site
316056007356	phosphorylation site [posttranslational modification]
316056007357	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056007358	ATP binding site [chemical binding]; other site
316056007359	Mg2+ binding site [ion binding]; other site
316056007360	G-X-G motif; other site
316056007361	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
316056007362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056007363	active site
316056007364	phosphorylation site [posttranslational modification]
316056007365	intermolecular recognition site; other site
316056007366	dimerization interface [polypeptide binding]; other site
316056007367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056007368	Walker A motif; other site
316056007369	ATP binding site [chemical binding]; other site
316056007370	Walker B motif; other site
316056007371	arginine finger; other site
316056007372	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316056007373	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
316056007374	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
316056007375	homodimer interface [polypeptide binding]; other site
316056007376	substrate-cofactor binding pocket; other site
316056007377	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056007378	catalytic residue [active]
316056007379	bacterial Hfq-like; Region: Hfq; cd01716
316056007380	hexamer interface [polypeptide binding]; other site
316056007381	Sm1 motif; other site
316056007382	RNA binding site [nucleotide binding]; other site
316056007383	Sm2 motif; other site
316056007384	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
316056007385	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
316056007386	HflX GTPase family; Region: HflX; cd01878
316056007387	G1 box; other site
316056007388	GTP/Mg2+ binding site [chemical binding]; other site
316056007389	Switch I region; other site
316056007390	G2 box; other site
316056007391	G3 box; other site
316056007392	Switch II region; other site
316056007393	G4 box; other site
316056007394	G5 box; other site
316056007395	DNA gyrase, A subunit; Region: gyrA; TIGR01063
316056007396	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
316056007397	CAP-like domain; other site
316056007398	active site
316056007399	primary dimer interface [polypeptide binding]; other site
316056007400	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
316056007401	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
316056007402	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
316056007403	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
316056007404	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
316056007405	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
316056007406	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316056007407	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
316056007408	catalytic triad [active]
316056007409	putative active site [active]
316056007410	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
316056007411	Autotransporter beta-domain; Region: Autotransporter; smart00869
316056007412	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
316056007413	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
316056007414	active site
316056007415	(T/H)XGH motif; other site
316056007416	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
316056007417	active site
316056007418	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
316056007419	active site
316056007420	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
316056007421	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
316056007422	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
316056007423	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
316056007424	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
316056007425	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
316056007426	dimer interface [polypeptide binding]; other site
316056007427	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056007428	catalytic residue [active]
316056007429	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
316056007430	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
316056007431	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
316056007432	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
316056007433	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
316056007434	active site
316056007435	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
316056007436	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
316056007437	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
316056007438	Substrate binding site; other site
316056007439	Mg++ binding site; other site
316056007440	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
316056007441	active site
316056007442	substrate binding site [chemical binding]; other site
316056007443	CoA binding site [chemical binding]; other site
316056007444	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
316056007445	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
316056007446	glutaminase active site [active]
316056007447	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
316056007448	dimer interface [polypeptide binding]; other site
316056007449	active site
316056007450	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
316056007451	dimer interface [polypeptide binding]; other site
316056007452	active site
316056007453	Uncharacterized conserved protein [Function unknown]; Region: COG2928
316056007454	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
316056007455	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
316056007456	generic binding surface II; other site
316056007457	ssDNA binding site; other site
316056007458	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316056007459	ATP binding site [chemical binding]; other site
316056007460	putative Mg++ binding site [ion binding]; other site
316056007461	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316056007462	nucleotide binding region [chemical binding]; other site
316056007463	ATP-binding site [chemical binding]; other site
316056007464	Uncharacterized conserved protein [Function unknown]; Region: COG2938
316056007465	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
316056007466	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
316056007467	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316056007468	ATP binding site [chemical binding]; other site
316056007469	putative Mg++ binding site [ion binding]; other site
316056007470	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316056007471	nucleotide binding region [chemical binding]; other site
316056007472	ATP-binding site [chemical binding]; other site
316056007473	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
316056007474	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056007475	metal binding site [ion binding]; metal-binding site
316056007476	I-site; other site
316056007477	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
316056007478	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056007479	acyl-activating enzyme (AAE) consensus motif; other site
316056007480	active site
316056007481	CoA binding site [chemical binding]; other site
316056007482	AMP binding site [chemical binding]; other site
316056007483	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
316056007484	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
316056007485	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
316056007486	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
316056007487	Predicted permeases [General function prediction only]; Region: COG0679
316056007488	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
316056007489	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
316056007490	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
316056007491	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
316056007492	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
316056007493	NADP binding site [chemical binding]; other site
316056007494	dimer interface [polypeptide binding]; other site
316056007495	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
316056007496	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
316056007497	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056007498	FeS/SAM binding site; other site
316056007499	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
316056007500	putative active site [active]
316056007501	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
316056007502	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
316056007503	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
316056007504	hypothetical protein; Validated; Region: PRK08245
316056007505	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
316056007506	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056007507	Predicted transcriptional regulator [Transcription]; Region: COG1959
316056007508	Transcriptional regulator; Region: Rrf2; pfam02082
316056007509	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
316056007510	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
316056007511	dimer interface [polypeptide binding]; other site
316056007512	active site
316056007513	catalytic residue [active]
316056007514	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
316056007515	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
316056007516	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
316056007517	SmpB-tmRNA interface; other site
316056007518	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
316056007519	Fe-S cluster binding site [ion binding]; other site
316056007520	DNA binding site [nucleotide binding]
316056007521	active site
316056007522	Uncharacterized conserved protein [Function unknown]; Region: COG1432
316056007523	LabA_like proteins; Region: LabA; cd10911
316056007524	putative metal binding site [ion binding]; other site
316056007525	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
316056007526	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
316056007527	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
316056007528	Zn2+ binding site [ion binding]; other site
316056007529	Mg2+ binding site [ion binding]; other site
316056007530	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
316056007531	synthetase active site [active]
316056007532	NTP binding site [chemical binding]; other site
316056007533	metal binding site [ion binding]; metal-binding site
316056007534	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
316056007535	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
316056007536	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
316056007537	active site
316056007538	hydrophilic channel; other site
316056007539	dimerization interface [polypeptide binding]; other site
316056007540	catalytic residues [active]
316056007541	active site lid [active]
316056007542	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
316056007543	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
316056007544	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
316056007545	Catalytic site [active]
316056007546	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
316056007547	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
316056007548	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
316056007549	dimerization interface [polypeptide binding]; other site
316056007550	active site
316056007551	metal binding site [ion binding]; metal-binding site
316056007552	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
316056007553	dsRNA binding site [nucleotide binding]; other site
316056007554	GTPase Era; Reviewed; Region: era; PRK00089
316056007555	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
316056007556	G1 box; other site
316056007557	GTP/Mg2+ binding site [chemical binding]; other site
316056007558	Switch I region; other site
316056007559	G2 box; other site
316056007560	Switch II region; other site
316056007561	G3 box; other site
316056007562	G4 box; other site
316056007563	G5 box; other site
316056007564	KH domain; Region: KH_2; pfam07650
316056007565	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
316056007566	Recombination protein O N terminal; Region: RecO_N; pfam11967
316056007567	Recombination protein O C terminal; Region: RecO_C; pfam02565
316056007568	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
316056007569	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
316056007570	CAP-like domain; other site
316056007571	active site
316056007572	primary dimer interface [polypeptide binding]; other site
316056007573	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056007574	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056007575	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316056007576	dimerization interface [polypeptide binding]; other site
316056007577	manganese transport protein MntH; Reviewed; Region: PRK00701
316056007578	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
316056007579	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
316056007580	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
316056007581	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
316056007582	RDD family; Region: RDD; pfam06271
316056007583	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
316056007584	dimer interface [polypeptide binding]; other site
316056007585	allosteric magnesium binding site [ion binding]; other site
316056007586	active site
316056007587	aspartate-rich active site metal binding site; other site
316056007588	Schiff base residues; other site
316056007589	Transcriptional regulators [Transcription]; Region: MarR; COG1846
316056007590	MarR family; Region: MarR_2; cl17246
316056007591	tRNA synthetases class I (K); Region: tRNA-synt_1f; pfam01921
316056007592	TIR domain; Region: TIR_2; pfam13676
316056007593	TIR domain; Region: TIR_2; cl17458
316056007594	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
316056007595	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
316056007596	dimer interface [polypeptide binding]; other site
316056007597	active site
316056007598	glycine-pyridoxal phosphate binding site [chemical binding]; other site
316056007599	folate binding site [chemical binding]; other site
316056007600	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
316056007601	ATP cone domain; Region: ATP-cone; pfam03477
316056007602	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
316056007603	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
316056007604	catalytic motif [active]
316056007605	Zn binding site [ion binding]; other site
316056007606	RibD C-terminal domain; Region: RibD_C; cl17279
316056007607	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
316056007608	Lumazine binding domain; Region: Lum_binding; pfam00677
316056007609	Lumazine binding domain; Region: Lum_binding; pfam00677
316056007610	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
316056007611	homopentamer interface [polypeptide binding]; other site
316056007612	active site
316056007613	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
316056007614	putative RNA binding site [nucleotide binding]; other site
316056007615	thiamine monophosphate kinase; Provisional; Region: PRK05731
316056007616	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
316056007617	ATP binding site [chemical binding]; other site
316056007618	dimerization interface [polypeptide binding]; other site
316056007619	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
316056007620	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
316056007621	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
316056007622	trimer interface [polypeptide binding]; other site
316056007623	active site
316056007624	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
316056007625	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
316056007626	DNA interaction; other site
316056007627	Metal-binding active site; metal-binding site
316056007628	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
316056007629	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
316056007630	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981
316056007631	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
316056007632	putative phosphate acyltransferase; Provisional; Region: PRK05331
316056007633	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
316056007634	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
316056007635	dimer interface [polypeptide binding]; other site
316056007636	active site
316056007637	CoA binding pocket [chemical binding]; other site
316056007638	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
316056007639	IHF dimer interface [polypeptide binding]; other site
316056007640	IHF - DNA interface [nucleotide binding]; other site
316056007641	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
316056007642	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
316056007643	DNA binding residues [nucleotide binding]
316056007644	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
316056007645	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
316056007646	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
316056007647	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
316056007648	Chain length determinant protein; Region: Wzz; pfam02706
316056007649	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
316056007650	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
316056007651	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
316056007652	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
316056007653	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
316056007654	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
316056007655	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
316056007656	CrcB-like protein; Region: CRCB; cl09114
316056007657	camphor resistance protein CrcB; Provisional; Region: PRK14203
316056007658	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
316056007659	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
316056007660	homodimer interface [polypeptide binding]; other site
316056007661	substrate-cofactor binding pocket; other site
316056007662	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056007663	catalytic residue [active]
316056007664	Iron permease FTR1 family; Region: FTR1; cl00475
316056007665	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
316056007666	enoyl-CoA hydratase; Validated; Region: PRK08139
316056007667	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056007668	substrate binding site [chemical binding]; other site
316056007669	oxyanion hole (OAH) forming residues; other site
316056007670	trimer interface [polypeptide binding]; other site
316056007671	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
316056007672	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
316056007673	CoenzymeA binding site [chemical binding]; other site
316056007674	subunit interaction site [polypeptide binding]; other site
316056007675	PHB binding site; other site
316056007676	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
316056007677	23S rRNA interface [nucleotide binding]; other site
316056007678	L3 interface [polypeptide binding]; other site
316056007679	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
316056007680	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056007681	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056007682	metal binding site [ion binding]; metal-binding site
316056007683	active site
316056007684	I-site; other site
316056007685	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
316056007686	Domain of unknown function DUF20; Region: UPF0118; pfam01594
316056007687	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
316056007688	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
316056007689	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
316056007690	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
316056007691	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
316056007692	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
316056007693	thymidylate kinase; Region: DTMP_kinase; TIGR00041
316056007694	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
316056007695	TMP-binding site; other site
316056007696	ATP-binding site [chemical binding]; other site
316056007697	DNA polymerase III subunit delta'; Validated; Region: PRK07471
316056007698	DNA polymerase III subunit delta'; Validated; Region: PRK08485
316056007699	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
316056007700	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
316056007701	active site
316056007702	HIGH motif; other site
316056007703	KMSKS motif; other site
316056007704	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
316056007705	tRNA binding surface [nucleotide binding]; other site
316056007706	anticodon binding site; other site
316056007707	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
316056007708	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
316056007709	active site
316056007710	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
316056007711	putative hydrolase; Provisional; Region: PRK02113
316056007712	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
316056007713	Autotransporter beta-domain; Region: Autotransporter; smart00869
316056007714	acyl-CoA synthetase; Validated; Region: PRK08162
316056007715	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
316056007716	acyl-activating enzyme (AAE) consensus motif; other site
316056007717	putative active site [active]
316056007718	AMP binding site [chemical binding]; other site
316056007719	putative CoA binding site [chemical binding]; other site
316056007720	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
316056007721	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
316056007722	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056007723	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056007724	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
316056007725	putative effector binding pocket; other site
316056007726	dimerization interface [polypeptide binding]; other site
316056007727	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
316056007728	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
316056007729	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
316056007730	N-terminal domain interface [polypeptide binding]; other site
316056007731	dimer interface [polypeptide binding]; other site
316056007732	substrate binding pocket (H-site) [chemical binding]; other site
316056007733	hypothetical protein; Validated; Region: PRK06201
316056007734	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
316056007735	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
316056007736	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
316056007737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056007738	putative substrate translocation pore; other site
316056007739	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
316056007740	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
316056007741	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
316056007742	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
316056007743	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056007744	putative substrate translocation pore; other site
316056007745	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
316056007746	FAD binding domain; Region: FAD_binding_4; pfam01565
316056007747	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
316056007748	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
316056007749	Strictosidine synthase; Region: Str_synth; pfam03088
316056007750	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
316056007751	Transcriptional regulator [Transcription]; Region: IclR; COG1414
316056007752	Bacterial transcriptional regulator; Region: IclR; pfam01614
316056007753	Propionate catabolism activator; Region: PrpR_N; pfam06506
316056007754	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
316056007755	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056007756	Walker A motif; other site
316056007757	ATP binding site [chemical binding]; other site
316056007758	Walker B motif; other site
316056007759	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316056007760	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
316056007761	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
316056007762	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
316056007763	active site
316056007764	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
316056007765	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
316056007766	transmembrane helices; other site
316056007767	hypothetical protein; Validated; Region: PRK06201
316056007768	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
316056007769	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
316056007770	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
316056007771	ligand binding site [chemical binding]; other site
316056007772	NAD binding site [chemical binding]; other site
316056007773	dimerization interface [polypeptide binding]; other site
316056007774	catalytic site [active]
316056007775	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
316056007776	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
316056007777	Protein export membrane protein; Region: SecD_SecF; cl14618
316056007778	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
316056007779	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056007780	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056007781	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
316056007782	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056007783	Coenzyme A binding pocket [chemical binding]; other site
316056007784	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
316056007785	Bacterial SH3 domain; Region: SH3_3; pfam08239
316056007786	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
316056007787	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316056007788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056007789	active site
316056007790	phosphorylation site [posttranslational modification]
316056007791	intermolecular recognition site; other site
316056007792	dimerization interface [polypeptide binding]; other site
316056007793	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056007794	DNA binding site [nucleotide binding]
316056007795	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056007796	dimerization interface [polypeptide binding]; other site
316056007797	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056007798	dimer interface [polypeptide binding]; other site
316056007799	phosphorylation site [posttranslational modification]
316056007800	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056007801	Mg2+ binding site [ion binding]; other site
316056007802	G-X-G motif; other site
316056007803	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
316056007804	Sulfatase; Region: Sulfatase; cl17466
316056007805	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
316056007806	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
316056007807	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
316056007808	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056007809	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
316056007810	dimerization interface [polypeptide binding]; other site
316056007811	substrate binding pocket [chemical binding]; other site
316056007812	metabolite-proton symporter; Region: 2A0106; TIGR00883
316056007813	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056007814	putative substrate translocation pore; other site
316056007815	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
316056007816	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
316056007817	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056007818	dimer interface [polypeptide binding]; other site
316056007819	putative CheW interface [polypeptide binding]; other site
316056007820	HAMP domain; Region: HAMP; pfam00672
316056007821	dimerization interface [polypeptide binding]; other site
316056007822	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056007823	dimer interface [polypeptide binding]; other site
316056007824	putative CheW interface [polypeptide binding]; other site
316056007825	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056007826	dimerization interface [polypeptide binding]; other site
316056007827	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056007828	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
316056007829	dimer interface [polypeptide binding]; other site
316056007830	putative CheW interface [polypeptide binding]; other site
316056007831	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
316056007832	Part of AAA domain; Region: AAA_19; pfam13245
316056007833	Family description; Region: UvrD_C_2; pfam13538
316056007834	Putative mono-oxygenase ydhR; Region: ydhR; cl07420
316056007835	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
316056007836	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
316056007837	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
316056007838	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
316056007839	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
316056007840	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
316056007841	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
316056007842	Ligand Binding Site [chemical binding]; other site
316056007843	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
316056007844	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
316056007845	homodimer interface [polypeptide binding]; other site
316056007846	metal binding site [ion binding]; metal-binding site
316056007847	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
316056007848	homodimer interface [polypeptide binding]; other site
316056007849	active site
316056007850	putative chemical substrate binding site [chemical binding]; other site
316056007851	metal binding site [ion binding]; metal-binding site
316056007852	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
316056007853	Domain of unknown function DUF21; Region: DUF21; pfam01595
316056007854	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
316056007855	Transporter associated domain; Region: CorC_HlyC; smart01091
316056007856	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
316056007857	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
316056007858	dimer interface [polypeptide binding]; other site
316056007859	ssDNA binding site [nucleotide binding]; other site
316056007860	tetramer (dimer of dimers) interface [polypeptide binding]; other site
316056007861	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
316056007862	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
316056007863	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
316056007864	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056007865	ABC transporter signature motif; other site
316056007866	Walker B; other site
316056007867	D-loop; other site
316056007868	H-loop/switch region; other site
316056007869	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
316056007870	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
316056007871	Protein of unknown function (DUF433); Region: DUF433; pfam04255
316056007872	Protein of unknown function (DUF433); Region: DUF433; pfam04255
316056007873	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
316056007874	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
316056007875	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
316056007876	FAD binding pocket [chemical binding]; other site
316056007877	FAD binding motif [chemical binding]; other site
316056007878	phosphate binding motif [ion binding]; other site
316056007879	beta-alpha-beta structure motif; other site
316056007880	NAD binding pocket [chemical binding]; other site
316056007881	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
316056007882	Ion channel; Region: Ion_trans_2; pfam07885
316056007883	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
316056007884	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
316056007885	Predicted acetyltransferase [General function prediction only]; Region: COG2388
316056007886	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
316056007887	Predicted integral membrane protein [Function unknown]; Region: COG5473
316056007888	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
316056007889	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
316056007890	Glucose inhibited division protein A; Region: GIDA; pfam01134
316056007891	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
316056007892	substrate binding pocket [chemical binding]; other site
316056007893	substrate-Mg2+ binding site; other site
316056007894	aspartate-rich region 1; other site
316056007895	aspartate-rich region 2; other site
316056007896	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
316056007897	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
316056007898	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
316056007899	Protein export membrane protein; Region: SecD_SecF; pfam02355
316056007900	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
316056007901	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
316056007902	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
316056007903	Preprotein translocase subunit; Region: YajC; pfam02699
316056007904	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
316056007905	Protein of unknown function (DUF815); Region: DUF815; pfam05673
316056007906	Walker A motif; other site
316056007907	ATP binding site [chemical binding]; other site
316056007908	Walker B motif; other site
316056007909	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
316056007910	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
316056007911	active site
316056007912	catalytic residues [active]
316056007913	metal binding site [ion binding]; metal-binding site
316056007914	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
316056007915	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
316056007916	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
316056007917	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
316056007918	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
316056007919	carboxyltransferase (CT) interaction site; other site
316056007920	biotinylation site [posttranslational modification]; other site
316056007921	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
316056007922	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
316056007923	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
316056007924	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
316056007925	OpgC protein; Region: OpgC_C; pfam10129
316056007926	Acyltransferase family; Region: Acyl_transf_3; pfam01757
316056007927	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
316056007928	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
316056007929	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316056007930	catalytic residue [active]
316056007931	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
316056007932	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
316056007933	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
316056007934	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
316056007935	DNA-binding site [nucleotide binding]; DNA binding site
316056007936	RNA-binding motif; other site
316056007937	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
316056007938	DNA-binding site [nucleotide binding]; DNA binding site
316056007939	RNA-binding motif; other site
316056007940	NAD-dependent deacetylase; Provisional; Region: PRK00481
316056007941	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
316056007942	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
316056007943	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
316056007944	dimer interface [polypeptide binding]; other site
316056007945	active site
316056007946	metal binding site [ion binding]; metal-binding site
316056007947	glutathione binding site [chemical binding]; other site
316056007948	PilZ domain; Region: PilZ; pfam07238
316056007949	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
316056007950	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056007951	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056007952	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056007953	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056007954	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
316056007955	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
316056007956	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
316056007957	dimer interface [polypeptide binding]; other site
316056007958	active site
316056007959	CoA binding pocket [chemical binding]; other site
316056007960	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
316056007961	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
316056007962	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
316056007963	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
316056007964	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056007965	FeS/SAM binding site; other site
316056007966	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
316056007967	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
316056007968	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
316056007969	motif 1; other site
316056007970	dimer interface [polypeptide binding]; other site
316056007971	active site
316056007972	motif 2; other site
316056007973	motif 3; other site
316056007974	elongation factor P; Validated; Region: PRK00529
316056007975	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
316056007976	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
316056007977	RNA binding site [nucleotide binding]; other site
316056007978	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
316056007979	RNA binding site [nucleotide binding]; other site
316056007980	Peptidase family M23; Region: Peptidase_M23; pfam01551
316056007981	lytic murein transglycosylase; Region: MltB_2; TIGR02283
316056007982	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316056007983	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316056007984	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
316056007985	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
316056007986	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
316056007987	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
316056007988	DHH family; Region: DHH; pfam01368
316056007989	DHHA1 domain; Region: DHHA1; pfam02272
316056007990	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
316056007991	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316056007992	motif II; other site
316056007993	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
316056007994	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
316056007995	putative active site [active]
316056007996	homoserine dehydrogenase; Provisional; Region: PRK06349
316056007997	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
316056007998	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
316056007999	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
316056008000	aminotransferase; Validated; Region: PRK09148
316056008001	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316056008002	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056008003	homodimer interface [polypeptide binding]; other site
316056008004	catalytic residue [active]
316056008005	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
316056008006	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
316056008007	MAPEG family; Region: MAPEG; pfam01124
316056008008	Methyltransferase domain; Region: Methyltransf_23; pfam13489
316056008009	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056008010	S-adenosylmethionine binding site [chemical binding]; other site
316056008011	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
316056008012	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
316056008013	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
316056008014	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
316056008015	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
316056008016	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
316056008017	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
316056008018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056008019	Mg2+ binding site [ion binding]; other site
316056008020	G-X-G motif; other site
316056008021	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
316056008022	anchoring element; other site
316056008023	dimer interface [polypeptide binding]; other site
316056008024	ATP binding site [chemical binding]; other site
316056008025	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
316056008026	active site
316056008027	metal binding site [ion binding]; metal-binding site
316056008028	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
316056008029	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
316056008030	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056008031	non-specific DNA binding site [nucleotide binding]; other site
316056008032	salt bridge; other site
316056008033	sequence-specific DNA binding site [nucleotide binding]; other site
316056008034	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
316056008035	helicase 45; Provisional; Region: PTZ00424
316056008036	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
316056008037	ATP binding site [chemical binding]; other site
316056008038	Mg++ binding site [ion binding]; other site
316056008039	motif III; other site
316056008040	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316056008041	nucleotide binding region [chemical binding]; other site
316056008042	ATP-binding site [chemical binding]; other site
316056008043	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056008044	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056008045	metal binding site [ion binding]; metal-binding site
316056008046	active site
316056008047	I-site; other site
316056008048	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
316056008049	Domain of unknown function DUF59; Region: DUF59; cl00941
316056008050	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
316056008051	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
316056008052	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316056008053	catalytic residue [active]
316056008054	FeS assembly protein SufD; Region: sufD; TIGR01981
316056008055	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
316056008056	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
316056008057	FeS assembly ATPase SufC; Region: sufC; TIGR01978
316056008058	Walker A/P-loop; other site
316056008059	ATP binding site [chemical binding]; other site
316056008060	Q-loop/lid; other site
316056008061	ABC transporter signature motif; other site
316056008062	Walker B; other site
316056008063	D-loop; other site
316056008064	H-loop/switch region; other site
316056008065	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
316056008066	putative active site [active]
316056008067	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
316056008068	putative ABC transporter; Region: ycf24; CHL00085
316056008069	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
316056008070	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
316056008071	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316056008072	catalytic residue [active]
316056008073	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
316056008074	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
316056008075	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
316056008076	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
316056008077	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
316056008078	active site
316056008079	HIGH motif; other site
316056008080	dimer interface [polypeptide binding]; other site
316056008081	KMSKS motif; other site
316056008082	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
316056008083	RNA binding surface [nucleotide binding]; other site
316056008084	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
316056008085	HAMP domain; Region: HAMP; pfam00672
316056008086	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056008087	dimer interface [polypeptide binding]; other site
316056008088	putative CheW interface [polypeptide binding]; other site
316056008089	Protein of unknown function; Region: DUF3971; pfam13116
316056008090	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
316056008091	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
316056008092	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
316056008093	catalytic triad [active]
316056008094	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
316056008095	Peptidase family M23; Region: Peptidase_M23; pfam01551
316056008096	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
316056008097	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
316056008098	peptide chain release factor 2; Provisional; Region: PRK07342
316056008099	This domain is found in peptide chain release factors; Region: PCRF; smart00937
316056008100	RF-1 domain; Region: RF-1; pfam00472
316056008101	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
316056008102	Transglycosylase; Region: Transgly; pfam00912
316056008103	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
316056008104	AMIN domain; Region: AMIN; pfam11741
316056008105	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
316056008106	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
316056008107	active site
316056008108	metal binding site [ion binding]; metal-binding site
316056008109	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
316056008110	RNA binding site [nucleotide binding]; other site
316056008111	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
316056008112	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
316056008113	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
316056008114	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
316056008115	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
316056008116	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
316056008117	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316056008118	N-terminal plug; other site
316056008119	ligand-binding site [chemical binding]; other site
316056008120	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
316056008121	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
316056008122	aspartate aminotransferase; Provisional; Region: PRK05764
316056008123	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316056008124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056008125	homodimer interface [polypeptide binding]; other site
316056008126	catalytic residue [active]
316056008127	Peptidase family M48; Region: Peptidase_M48; cl12018
316056008128	Tetratricopeptide repeat; Region: TPR_16; pfam13432
316056008129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
316056008130	binding surface
316056008131	TPR motif; other site
316056008132	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
316056008133	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
316056008134	catalytic residues [active]
316056008135	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
316056008136	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
316056008137	Dehydroquinase class II; Region: DHquinase_II; pfam01220
316056008138	trimer interface [polypeptide binding]; other site
316056008139	active site
316056008140	dimer interface [polypeptide binding]; other site
316056008141	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
316056008142	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
316056008143	carboxyltransferase (CT) interaction site; other site
316056008144	biotinylation site [posttranslational modification]; other site
316056008145	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
316056008146	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
316056008147	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
316056008148	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
316056008149	CHASE3 domain; Region: CHASE3; pfam05227
316056008150	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056008151	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056008152	ATP binding site [chemical binding]; other site
316056008153	Mg2+ binding site [ion binding]; other site
316056008154	G-X-G motif; other site
316056008155	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
316056008156	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056008157	active site
316056008158	phosphorylation site [posttranslational modification]
316056008159	intermolecular recognition site; other site
316056008160	dimerization interface [polypeptide binding]; other site
316056008161	Response regulator receiver domain; Region: Response_reg; pfam00072
316056008162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056008163	active site
316056008164	phosphorylation site [posttranslational modification]
316056008165	intermolecular recognition site; other site
316056008166	dimerization interface [polypeptide binding]; other site
316056008167	Histidine kinase; Region: HisKA_2; pfam07568
316056008168	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
316056008169	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056008170	ATP binding site [chemical binding]; other site
316056008171	Mg2+ binding site [ion binding]; other site
316056008172	G-X-G motif; other site
316056008173	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
316056008174	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
316056008175	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056008176	FeS/SAM binding site; other site
316056008177	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
316056008178	putative outer membrane lipoprotein; Provisional; Region: PRK10510
316056008179	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
316056008180	ligand binding site [chemical binding]; other site
316056008181	multidrug resistance protein (mdr1); Provisional; Region: PTZ00265
316056008182	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
316056008183	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923
316056008184	GAF domain; Region: GAF_3; pfam13492
316056008185	PAS domain S-box; Region: sensory_box; TIGR00229
316056008186	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056008187	putative active site [active]
316056008188	heme pocket [chemical binding]; other site
316056008189	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056008190	dimer interface [polypeptide binding]; other site
316056008191	phosphorylation site [posttranslational modification]
316056008192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056008193	ATP binding site [chemical binding]; other site
316056008194	G-X-G motif; other site
316056008195	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
316056008196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056008197	active site
316056008198	phosphorylation site [posttranslational modification]
316056008199	intermolecular recognition site; other site
316056008200	dimerization interface [polypeptide binding]; other site
316056008201	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
316056008202	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
316056008203	conserved cys residue [active]
316056008204	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
316056008205	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
316056008206	conserved cys residue [active]
316056008207	NADH dehydrogenase; Validated; Region: PRK08183
316056008208	BA14K-like protein; Region: BA14K; pfam07886
316056008209	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
316056008210	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316056008211	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316056008212	catalytic residue [active]
316056008213	Porin subfamily; Region: Porin_2; pfam02530
316056008214	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
316056008215	Uncharacterized conserved protein [Function unknown]; Region: COG2966
316056008216	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
316056008217	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
316056008218	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316056008219	ribulose bisphosphate carboxylase; Provisional; Region: PRK13475
316056008220	Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211
316056008221	dimer interface [polypeptide binding]; other site
316056008222	active site
316056008223	catalytic residue [active]
316056008224	metal binding site [ion binding]; metal-binding site
316056008225	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
316056008226	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
316056008227	intersubunit interface [polypeptide binding]; other site
316056008228	active site
316056008229	zinc binding site [ion binding]; other site
316056008230	Na+ binding site [ion binding]; other site
316056008231	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
316056008232	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
316056008233	TPP-binding site [chemical binding]; other site
316056008234	dimer interface [polypeptide binding]; other site
316056008235	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
316056008236	PYR/PP interface [polypeptide binding]; other site
316056008237	dimer interface [polypeptide binding]; other site
316056008238	TPP binding site [chemical binding]; other site
316056008239	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
316056008240	phosphoribulokinase; Provisional; Region: PRK15453
316056008241	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
316056008242	metal binding site [ion binding]; metal-binding site
316056008243	active site
316056008244	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
316056008245	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
316056008246	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
316056008247	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
316056008248	FecR protein; Region: FecR; pfam04773
316056008249	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
316056008250	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316056008251	DNA binding residues [nucleotide binding]
316056008252	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
316056008253	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
316056008254	Secretin and TonB N terminus short domain; Region: STN; smart00965
316056008255	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
316056008256	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316056008257	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316056008258	catalytic residue [active]
316056008259	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
316056008260	Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545
316056008261	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
316056008262	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
316056008263	TonB C terminal; Region: TonB_2; pfam13103
316056008264	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
316056008265	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
316056008266	Domain of unknown function (DUF2341); Region: DUF2341; pfam10102
316056008267	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
316056008268	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
316056008269	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
316056008270	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
316056008271	Transposase; Region: HTH_Tnp_1; pfam01527
316056008272	Arginase family; Region: Arginase; cd09989
316056008273	active site
316056008274	Mn binding site [ion binding]; other site
316056008275	oligomer interface [polypeptide binding]; other site
316056008276	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
316056008277	oligomeric interface; other site
316056008278	putative active site [active]
316056008279	homodimer interface [polypeptide binding]; other site
316056008280	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
316056008281	Protein of unknown function (DUF3222); Region: DUF3222; pfam11519
316056008282	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
316056008283	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
316056008284	Methyltransferase domain; Region: Methyltransf_23; pfam13489
316056008285	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056008286	S-adenosylmethionine binding site [chemical binding]; other site
316056008287	Protein of unknown function (DUF466); Region: DUF466; pfam04328
316056008288	carbon starvation protein A; Provisional; Region: PRK15015
316056008289	Carbon starvation protein CstA; Region: CstA; pfam02554
316056008290	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
316056008291	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
316056008292	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
316056008293	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
316056008294	G1 box; other site
316056008295	putative GEF interaction site [polypeptide binding]; other site
316056008296	GTP/Mg2+ binding site [chemical binding]; other site
316056008297	Switch I region; other site
316056008298	G2 box; other site
316056008299	G3 box; other site
316056008300	Switch II region; other site
316056008301	G4 box; other site
316056008302	G5 box; other site
316056008303	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
316056008304	multidrug efflux system protein; Provisional; Region: PRK11431
316056008305	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
316056008306	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
316056008307	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
316056008308	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316056008309	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316056008310	TM-ABC transporter signature motif; other site
316056008311	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316056008312	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316056008313	TM-ABC transporter signature motif; other site
316056008314	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
316056008315	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
316056008316	putative ligand binding site [chemical binding]; other site
316056008317	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
316056008318	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316056008319	Walker A/P-loop; other site
316056008320	ATP binding site [chemical binding]; other site
316056008321	Q-loop/lid; other site
316056008322	ABC transporter signature motif; other site
316056008323	Walker B; other site
316056008324	D-loop; other site
316056008325	H-loop/switch region; other site
316056008326	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
316056008327	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316056008328	Walker A/P-loop; other site
316056008329	ATP binding site [chemical binding]; other site
316056008330	Q-loop/lid; other site
316056008331	ABC transporter signature motif; other site
316056008332	Walker B; other site
316056008333	D-loop; other site
316056008334	H-loop/switch region; other site
316056008335	pyruvate kinase; Validated; Region: PRK08187
316056008336	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
316056008337	domain interfaces; other site
316056008338	active site
316056008339	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
316056008340	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
316056008341	ArsC family; Region: ArsC; pfam03960
316056008342	putative catalytic residues [active]
316056008343	Protein of unknown function (DUF3374); Region: DUF3374; cl11904
316056008344	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
316056008345	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
316056008346	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
316056008347	SnoaL-like domain; Region: SnoaL_2; pfam12680
316056008348	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
316056008349	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
316056008350	Transcriptional regulators [Transcription]; Region: MarR; COG1846
316056008351	MarR family; Region: MarR_2; pfam12802
316056008352	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
316056008353	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316056008354	putative DNA binding site [nucleotide binding]; other site
316056008355	putative Zn2+ binding site [ion binding]; other site
316056008356	AsnC family; Region: AsnC_trans_reg; pfam01037
316056008357	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
316056008358	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
316056008359	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056008360	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
316056008361	NAD(P) binding site [chemical binding]; other site
316056008362	active site
316056008363	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
316056008364	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056008365	acyl-activating enzyme (AAE) consensus motif; other site
316056008366	AMP binding site [chemical binding]; other site
316056008367	active site
316056008368	CoA binding site [chemical binding]; other site
316056008369	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
316056008370	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316056008371	Walker A/P-loop; other site
316056008372	ATP binding site [chemical binding]; other site
316056008373	Q-loop/lid; other site
316056008374	ABC transporter signature motif; other site
316056008375	Walker B; other site
316056008376	D-loop; other site
316056008377	H-loop/switch region; other site
316056008378	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
316056008379	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
316056008380	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316056008381	Walker A/P-loop; other site
316056008382	ATP binding site [chemical binding]; other site
316056008383	Q-loop/lid; other site
316056008384	ABC transporter signature motif; other site
316056008385	Walker B; other site
316056008386	D-loop; other site
316056008387	H-loop/switch region; other site
316056008388	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316056008389	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
316056008390	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056008391	dimer interface [polypeptide binding]; other site
316056008392	conserved gate region; other site
316056008393	putative PBP binding loops; other site
316056008394	ABC-ATPase subunit interface; other site
316056008395	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
316056008396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056008397	dimer interface [polypeptide binding]; other site
316056008398	conserved gate region; other site
316056008399	putative PBP binding loops; other site
316056008400	ABC-ATPase subunit interface; other site
316056008401	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
316056008402	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
316056008403	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
316056008404	CoenzymeA binding site [chemical binding]; other site
316056008405	subunit interaction site [polypeptide binding]; other site
316056008406	PHB binding site; other site
316056008407	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
316056008408	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
316056008409	NAD(P) binding site [chemical binding]; other site
316056008410	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233
316056008411	putative active site [active]
316056008412	Zn binding site [ion binding]; other site
316056008413	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
316056008414	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
316056008415	aspartate racemase; Region: asp_race; TIGR00035
316056008416	Domain of unknown function (DUF378); Region: DUF378; pfam04070
316056008417	Pyruvate formate lyase 1; Region: PFL1; cd01678
316056008418	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
316056008419	coenzyme A binding site [chemical binding]; other site
316056008420	active site
316056008421	catalytic residues [active]
316056008422	glycine loop; other site
316056008423	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
316056008424	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056008425	FeS/SAM binding site; other site
316056008426	Predicted membrane protein [Function unknown]; Region: COG2261
316056008427	short chain dehydrogenase; Provisional; Region: PRK06197
316056008428	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
316056008429	putative NAD(P) binding site [chemical binding]; other site
316056008430	active site
316056008431	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
316056008432	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316056008433	ATP binding site [chemical binding]; other site
316056008434	putative Mg++ binding site [ion binding]; other site
316056008435	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316056008436	nucleotide binding region [chemical binding]; other site
316056008437	ATP-binding site [chemical binding]; other site
316056008438	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
316056008439	HRDC domain; Region: HRDC; pfam00570
316056008440	Homeodomain-like domain; Region: HTH_23; pfam13384
316056008441	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
316056008442	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
316056008443	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
316056008444	Gram-negative bacterial tonB protein; Region: TonB; cl10048
316056008445	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
316056008446	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
316056008447	Domain of unknown function (DUF2341); Region: DUF2341; pfam10102
316056008448	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
316056008449	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
316056008450	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
316056008451	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
316056008452	C2 domain; Region: C2; cl14603
316056008453	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
316056008454	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316056008455	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316056008456	DNA binding residues [nucleotide binding]
316056008457	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
316056008458	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316056008459	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316056008460	catalytic residue [active]
316056008461	haemagglutination activity domain; Region: Haemagg_act; smart00912
316056008462	Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545
316056008463	PBP superfamily domain; Region: PBP_like_2; cl17296
316056008464	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
316056008465	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
316056008466	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
316056008467	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
316056008468	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
316056008469	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
316056008470	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
316056008471	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
316056008472	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
316056008473	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
316056008474	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
316056008475	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
316056008476	type II secretion system protein E; Region: type_II_gspE; TIGR02533
316056008477	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
316056008478	Walker A motif; other site
316056008479	ATP binding site [chemical binding]; other site
316056008480	Walker B motif; other site
316056008481	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
316056008482	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
316056008483	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
316056008484	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
316056008485	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
316056008486	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
316056008487	Sel1-like repeats; Region: SEL1; smart00671
316056008488	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
316056008489	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
316056008490	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
316056008491	classical (c) SDRs; Region: SDR_c; cd05233
316056008492	NAD(P) binding site [chemical binding]; other site
316056008493	active site
316056008494	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
316056008495	Predicted amidohydrolase [General function prediction only]; Region: COG0388
316056008496	active site
316056008497	catalytic triad [active]
316056008498	dimer interface [polypeptide binding]; other site
316056008499	Second nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R2; cd07579
316056008500	Predicted amidohydrolase [General function prediction only]; Region: COG0388
316056008501	putative active site [active]
316056008502	catalytic triad [active]
316056008503	putative dimer interface [polypeptide binding]; other site
316056008504	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
316056008505	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
316056008506	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316056008507	Walker A/P-loop; other site
316056008508	ATP binding site [chemical binding]; other site
316056008509	Q-loop/lid; other site
316056008510	ABC transporter signature motif; other site
316056008511	Walker B; other site
316056008512	D-loop; other site
316056008513	H-loop/switch region; other site
316056008514	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
316056008515	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316056008516	Walker A/P-loop; other site
316056008517	ATP binding site [chemical binding]; other site
316056008518	Q-loop/lid; other site
316056008519	ABC transporter signature motif; other site
316056008520	Walker B; other site
316056008521	D-loop; other site
316056008522	H-loop/switch region; other site
316056008523	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
316056008524	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316056008525	TM-ABC transporter signature motif; other site
316056008526	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316056008527	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316056008528	TM-ABC transporter signature motif; other site
316056008529	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
316056008530	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356
316056008531	putative ligand binding site [chemical binding]; other site
316056008532	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
316056008533	ANTAR domain; Region: ANTAR; cl04297
316056008534	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
316056008535	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
316056008536	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
316056008537	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056008538	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056008539	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056008540	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316056008541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056008542	active site
316056008543	phosphorylation site [posttranslational modification]
316056008544	intermolecular recognition site; other site
316056008545	dimerization interface [polypeptide binding]; other site
316056008546	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056008547	DNA binding site [nucleotide binding]
316056008548	HAMP domain; Region: HAMP; pfam00672
316056008549	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056008550	dimer interface [polypeptide binding]; other site
316056008551	phosphorylation site [posttranslational modification]
316056008552	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056008553	ATP binding site [chemical binding]; other site
316056008554	Mg2+ binding site [ion binding]; other site
316056008555	G-X-G motif; other site
316056008556	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
316056008557	nucleophile elbow; other site
316056008558	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
316056008559	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316056008560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056008561	active site
316056008562	phosphorylation site [posttranslational modification]
316056008563	intermolecular recognition site; other site
316056008564	dimerization interface [polypeptide binding]; other site
316056008565	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056008566	DNA binding site [nucleotide binding]
316056008567	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
316056008568	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
316056008569	Condensation domain; Region: Condensation; pfam00668
316056008570	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316056008571	Nonribosomal peptide synthase; Region: NRPS; pfam08415
316056008572	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
316056008573	acyl-activating enzyme (AAE) consensus motif; other site
316056008574	AMP binding site [chemical binding]; other site
316056008575	Methyltransferase domain; Region: Methyltransf_31; pfam13847
316056008576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056008577	S-adenosylmethionine binding site [chemical binding]; other site
316056008578	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056008579	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056008580	Thioesterase domain; Region: Thioesterase; pfam00975
316056008581	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056008582	S-adenosylmethionine binding site [chemical binding]; other site
316056008583	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
316056008584	Thioesterase domain; Region: Thioesterase; pfam00975
316056008585	Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693
316056008586	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
316056008587	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
316056008588	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
316056008589	active site
316056008590	Methyltransferase domain; Region: Methyltransf_12; pfam08242
316056008591	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
316056008592	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
316056008593	NADP binding site [chemical binding]; other site
316056008594	active site
316056008595	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056008596	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056008597	Condensation domain; Region: Condensation; pfam00668
316056008598	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316056008599	acyl-CoA synthetase; Validated; Region: PRK05850
316056008600	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
316056008601	acyl-activating enzyme (AAE) consensus motif; other site
316056008602	active site
316056008603	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
316056008604	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
316056008605	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
316056008606	active site
316056008607	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
316056008608	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
316056008609	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
316056008610	KR domain; Region: KR; pfam08659
316056008611	NADP binding site [chemical binding]; other site
316056008612	active site
316056008613	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056008614	Condensation domain; Region: Condensation; pfam00668
316056008615	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316056008616	Nonribosomal peptide synthase; Region: NRPS; pfam08415
316056008617	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
316056008618	acyl-activating enzyme (AAE) consensus motif; other site
316056008619	AMP binding site [chemical binding]; other site
316056008620	Methyltransferase domain; Region: Methyltransf_12; pfam08242
316056008621	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056008622	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056008623	Condensation domain; Region: Condensation; pfam00668
316056008624	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316056008625	Nonribosomal peptide synthase; Region: NRPS; pfam08415
316056008626	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056008627	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
316056008628	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056008629	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056008630	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
316056008631	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316056008632	Walker A/P-loop; other site
316056008633	ATP binding site [chemical binding]; other site
316056008634	Q-loop/lid; other site
316056008635	ABC transporter signature motif; other site
316056008636	Walker B; other site
316056008637	D-loop; other site
316056008638	H-loop/switch region; other site
316056008639	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056008640	Walker A/P-loop; other site
316056008641	ATP binding site [chemical binding]; other site
316056008642	Q-loop/lid; other site
316056008643	ABC transporter signature motif; other site
316056008644	Walker B; other site
316056008645	D-loop; other site
316056008646	H-loop/switch region; other site
316056008647	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316056008648	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
316056008649	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
316056008650	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316056008651	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
316056008652	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
316056008653	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316056008654	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
316056008655	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316056008656	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056008657	Walker A/P-loop; other site
316056008658	ATP binding site [chemical binding]; other site
316056008659	Q-loop/lid; other site
316056008660	ABC transporter signature motif; other site
316056008661	Walker B; other site
316056008662	D-loop; other site
316056008663	H-loop/switch region; other site
316056008664	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
316056008665	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316056008666	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056008667	Walker A/P-loop; other site
316056008668	ATP binding site [chemical binding]; other site
316056008669	Q-loop/lid; other site
316056008670	ABC transporter signature motif; other site
316056008671	Walker B; other site
316056008672	D-loop; other site
316056008673	H-loop/switch region; other site
316056008674	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
316056008675	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056008676	Walker A motif; other site
316056008677	ATP binding site [chemical binding]; other site
316056008678	Walker B motif; other site
316056008679	arginine finger; other site
316056008680	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
316056008681	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
316056008682	DNA binding residues [nucleotide binding]
316056008683	Integrase core domain; Region: rve; pfam00665
316056008684	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
316056008685	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316056008686	N-terminal plug; other site
316056008687	ligand-binding site [chemical binding]; other site
316056008688	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
316056008689	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
316056008690	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
316056008691	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
316056008692	Restriction endonuclease; Region: Mrr_cat; pfam04471
316056008693	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
316056008694	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
316056008695	Superfamily II helicase [General function prediction only]; Region: COG1204
316056008696	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316056008697	ATP binding site [chemical binding]; other site
316056008698	putative Mg++ binding site [ion binding]; other site
316056008699	helicase superfamily c-terminal domain; Region: HELICc; smart00490
316056008700	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
316056008701	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
316056008702	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
316056008703	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
316056008704	DNA binding residues [nucleotide binding]
316056008705	Integrase core domain; Region: rve; pfam00665
316056008706	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
316056008707	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056008708	Walker A motif; other site
316056008709	ATP binding site [chemical binding]; other site
316056008710	Walker B motif; other site
316056008711	arginine finger; other site
316056008712	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861
316056008713	transposase; Validated; Region: PRK08181
316056008714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056008715	Walker A motif; other site
316056008716	ATP binding site [chemical binding]; other site
316056008717	Integrase core domain; Region: rve; pfam00665
316056008718	integrase; Provisional; Region: PRK09692
316056008719	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
316056008720	active site
316056008721	Int/Topo IB signature motif; other site
316056008722	GMP synthase; Reviewed; Region: guaA; PRK00074
316056008723	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
316056008724	AMP/PPi binding site [chemical binding]; other site
316056008725	candidate oxyanion hole; other site
316056008726	catalytic triad [active]
316056008727	potential glutamine specificity residues [chemical binding]; other site
316056008728	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
316056008729	ATP Binding subdomain [chemical binding]; other site
316056008730	Ligand Binding sites [chemical binding]; other site
316056008731	Dimerization subdomain; other site
316056008732	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
316056008733	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
316056008734	MAPEG family; Region: MAPEG; cl09190
316056008735	PAN domain; Region: PAN_4; pfam14295
316056008736	putative binding site; other site
316056008737	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
316056008738	Prostaglandin dehydrogenases; Region: PGDH; cd05288
316056008739	NAD(P) binding site [chemical binding]; other site
316056008740	substrate binding site [chemical binding]; other site
316056008741	dimer interface [polypeptide binding]; other site
316056008742	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
316056008743	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
316056008744	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
316056008745	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
316056008746	active site
316056008747	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
316056008748	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056008749	non-specific DNA binding site [nucleotide binding]; other site
316056008750	salt bridge; other site
316056008751	sequence-specific DNA binding site [nucleotide binding]; other site
316056008752	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
316056008753	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056008754	putative transporter; Provisional; Region: PRK10504
316056008755	putative substrate translocation pore; other site
316056008756	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
316056008757	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
316056008758	putative ligand binding site [chemical binding]; other site
316056008759	putative NAD binding site [chemical binding]; other site
316056008760	catalytic site [active]
316056008761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056008762	D-galactonate transporter; Region: 2A0114; TIGR00893
316056008763	putative substrate translocation pore; other site
316056008764	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056008765	hypothetical protein; Validated; Region: PRK06201
316056008766	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
316056008767	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056008768	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056008769	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
316056008770	dimerization interface [polypeptide binding]; other site
316056008771	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
316056008772	Part of AAA domain; Region: AAA_19; pfam13245
316056008773	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
316056008774	AAA domain; Region: AAA_12; pfam13087
316056008775	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
316056008776	putative active site [active]
316056008777	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
316056008778	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
316056008779	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056008780	S-adenosylmethionine binding site [chemical binding]; other site
316056008781	exopolyphosphatase; Region: exo_poly_only; TIGR03706
316056008782	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
316056008783	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
316056008784	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
316056008785	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
316056008786	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
316056008787	active site 2 [active]
316056008788	active site 1 [active]
316056008789	hypothetical protein; Validated; Region: PRK00124
316056008790	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
316056008791	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316056008792	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
316056008793	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
316056008794	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
316056008795	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
316056008796	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056008797	NAD(P) binding site [chemical binding]; other site
316056008798	active site
316056008799	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
316056008800	putative active site [active]
316056008801	putative catalytic site [active]
316056008802	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
316056008803	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
316056008804	active site
316056008805	acyl-activating enzyme (AAE) consensus motif; other site
316056008806	putative CoA binding site [chemical binding]; other site
316056008807	AMP binding site [chemical binding]; other site
316056008808	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
316056008809	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
316056008810	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
316056008811	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056008812	substrate binding site [chemical binding]; other site
316056008813	oxyanion hole (OAH) forming residues; other site
316056008814	trimer interface [polypeptide binding]; other site
316056008815	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
316056008816	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
316056008817	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
316056008818	substrate binding pocket [chemical binding]; other site
316056008819	FAD binding site [chemical binding]; other site
316056008820	catalytic base [active]
316056008821	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
316056008822	putative active site [active]
316056008823	homotetrameric interface [polypeptide binding]; other site
316056008824	metal binding site [ion binding]; metal-binding site
316056008825	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
316056008826	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
316056008827	tetrameric interface [polypeptide binding]; other site
316056008828	NAD binding site [chemical binding]; other site
316056008829	catalytic residues [active]
316056008830	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056008831	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056008832	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
316056008833	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
316056008834	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
316056008835	Transcriptional regulator [Transcription]; Region: IclR; COG1414
316056008836	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
316056008837	Bacterial transcriptional regulator; Region: IclR; pfam01614
316056008838	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
316056008839	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
316056008840	active site
316056008841	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
316056008842	ATP-NAD kinase; Region: NAD_kinase; pfam01513
316056008843	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
316056008844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056008845	Response regulator receiver domain; Region: Response_reg; pfam00072
316056008846	active site
316056008847	phosphorylation site [posttranslational modification]
316056008848	intermolecular recognition site; other site
316056008849	dimerization interface [polypeptide binding]; other site
316056008850	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
316056008851	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
316056008852	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316056008853	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316056008854	catalytic residue [active]
316056008855	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
316056008856	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
316056008857	GTP cyclohydrolase I; Provisional; Region: PLN03044
316056008858	active site
316056008859	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
316056008860	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
316056008861	trimerization site [polypeptide binding]; other site
316056008862	active site
316056008863	Predicted periplasmic protein [Function unknown]; Region: COG3904
316056008864	hypothetical protein; Validated; Region: PRK00041
316056008865	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
316056008866	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
316056008867	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
316056008868	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056008869	TPR motif; other site
316056008870	binding surface
316056008871	TPR repeat; Region: TPR_11; pfam13414
316056008872	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056008873	TPR motif; other site
316056008874	binding surface
316056008875	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056008876	binding surface
316056008877	TPR repeat; Region: TPR_11; pfam13414
316056008878	TPR motif; other site
316056008879	TPR repeat; Region: TPR_11; pfam13414
316056008880	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056008881	TPR motif; other site
316056008882	binding surface
316056008883	TPR repeat; Region: TPR_11; pfam13414
316056008884	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056008885	binding surface
316056008886	TPR motif; other site
316056008887	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056008888	binding surface
316056008889	TPR motif; other site
316056008890	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
316056008891	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
316056008892	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
316056008893	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
316056008894	active site
316056008895	dimer interface [polypeptide binding]; other site
316056008896	motif 1; other site
316056008897	motif 2; other site
316056008898	motif 3; other site
316056008899	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
316056008900	anticodon binding site; other site
316056008901	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
316056008902	putative FMN binding site [chemical binding]; other site
316056008903	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
316056008904	Transposase; Region: DEDD_Tnp_IS110; pfam01548
316056008905	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
316056008906	PAS domain S-box; Region: sensory_box; TIGR00229
316056008907	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056008908	putative active site [active]
316056008909	heme pocket [chemical binding]; other site
316056008910	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056008911	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056008912	metal binding site [ion binding]; metal-binding site
316056008913	active site
316056008914	I-site; other site
316056008915	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056008916	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
316056008917	nucleophile elbow; other site
316056008918	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
316056008919	FOG: CBS domain [General function prediction only]; Region: COG0517
316056008920	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
316056008921	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
316056008922	PAS domain; Region: PAS_5; pfam07310
316056008923	Response regulator receiver domain; Region: Response_reg; pfam00072
316056008924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056008925	active site
316056008926	phosphorylation site [posttranslational modification]
316056008927	intermolecular recognition site; other site
316056008928	dimerization interface [polypeptide binding]; other site
316056008929	PAS domain S-box; Region: sensory_box; TIGR00229
316056008930	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056008931	putative active site [active]
316056008932	heme pocket [chemical binding]; other site
316056008933	PAS domain S-box; Region: sensory_box; TIGR00229
316056008934	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056008935	putative active site [active]
316056008936	heme pocket [chemical binding]; other site
316056008937	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
316056008938	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056008939	putative active site [active]
316056008940	heme pocket [chemical binding]; other site
316056008941	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056008942	dimer interface [polypeptide binding]; other site
316056008943	phosphorylation site [posttranslational modification]
316056008944	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056008945	ATP binding site [chemical binding]; other site
316056008946	Mg2+ binding site [ion binding]; other site
316056008947	G-X-G motif; other site
316056008948	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
316056008949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056008950	active site
316056008951	phosphorylation site [posttranslational modification]
316056008952	intermolecular recognition site; other site
316056008953	dimerization interface [polypeptide binding]; other site
316056008954	PilZ domain; Region: PilZ; pfam07238
316056008955	PilZ domain; Region: PilZ; pfam07238
316056008956	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
316056008957	Transcriptional regulators [Transcription]; Region: MarR; COG1846
316056008958	MarR family; Region: MarR_2; cl17246
316056008959	MarR family; Region: MarR_2; cl17246
316056008960	Porin subfamily; Region: Porin_2; pfam02530
316056008961	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
316056008962	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
316056008963	trimer interface [polypeptide binding]; other site
316056008964	putative metal binding site [ion binding]; other site
316056008965	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
316056008966	serine acetyltransferase; Provisional; Region: cysE; PRK11132
316056008967	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
316056008968	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
316056008969	trimer interface [polypeptide binding]; other site
316056008970	active site
316056008971	substrate binding site [chemical binding]; other site
316056008972	CoA binding site [chemical binding]; other site
316056008973	Chromate transporter; Region: Chromate_transp; cl17781
316056008974	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
316056008975	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
316056008976	salicylate hydroxylase; Provisional; Region: PRK08163
316056008977	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
316056008978	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
316056008979	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
316056008980	putative catalytic residue [active]
316056008981	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
316056008982	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
316056008983	C-terminal domain interface [polypeptide binding]; other site
316056008984	GSH binding site (G-site) [chemical binding]; other site
316056008985	dimer interface [polypeptide binding]; other site
316056008986	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
316056008987	N-terminal domain interface [polypeptide binding]; other site
316056008988	putative dimer interface [polypeptide binding]; other site
316056008989	active site
316056008990	methionine synthase; Provisional; Region: PRK01207
316056008991	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
316056008992	substrate binding site [chemical binding]; other site
316056008993	THF binding site; other site
316056008994	zinc-binding site [ion binding]; other site
316056008995	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
316056008996	active site
316056008997	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
316056008998	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
316056008999	putative MPT binding site; other site
316056009000	Uncharacterized conserved protein [Function unknown]; Region: COG2308
316056009001	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
316056009002	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
316056009003	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
316056009004	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
316056009005	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
316056009006	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
316056009007	Transposase; Region: DEDD_Tnp_IS110; pfam01548
316056009008	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
316056009009	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056009010	dimerization interface [polypeptide binding]; other site
316056009011	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056009012	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056009013	dimer interface [polypeptide binding]; other site
316056009014	putative CheW interface [polypeptide binding]; other site
316056009015	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
316056009016	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
316056009017	active site
316056009018	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
316056009019	classical (c) SDRs; Region: SDR_c; cd05233
316056009020	NAD(P) binding site [chemical binding]; other site
316056009021	active site
316056009022	enterobactin exporter EntS; Provisional; Region: PRK10489
316056009023	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
316056009024	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
316056009025	Nucleoside recognition; Region: Gate; pfam07670
316056009026	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
316056009027	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
316056009028	AAA domain; Region: AAA_33; pfam13671
316056009029	Usg-like family; Region: Usg; pfam06233
316056009030	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
316056009031	oligomerisation interface [polypeptide binding]; other site
316056009032	mobile loop; other site
316056009033	roof hairpin; other site
316056009034	chaperonin GroEL; Provisional; Region: PRK14104
316056009035	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
316056009036	ring oligomerisation interface [polypeptide binding]; other site
316056009037	ATP/Mg binding site [chemical binding]; other site
316056009038	stacking interactions; other site
316056009039	hinge regions; other site
316056009040	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056009041	non-specific DNA binding site [nucleotide binding]; other site
316056009042	salt bridge; other site
316056009043	sequence-specific DNA binding site [nucleotide binding]; other site
316056009044	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
316056009045	GIY-YIG motif/motif A; other site
316056009046	putative active site [active]
316056009047	putative metal binding site [ion binding]; other site
316056009048	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
316056009049	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
316056009050	nucleophilic elbow; other site
316056009051	catalytic triad; other site
316056009052	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
316056009053	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
316056009054	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
316056009055	MarR family; Region: MarR; pfam01047
316056009056	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
316056009057	GIY-YIG motif/motif A; other site
316056009058	putative active site [active]
316056009059	putative metal binding site [ion binding]; other site
316056009060	Caspase domain; Region: Peptidase_C14; pfam00656
316056009061	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316056009062	dimerization interface [polypeptide binding]; other site
316056009063	putative DNA binding site [nucleotide binding]; other site
316056009064	putative Zn2+ binding site [ion binding]; other site
316056009065	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
316056009066	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056009067	NAD(P) binding site [chemical binding]; other site
316056009068	active site
316056009069	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
316056009070	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
316056009071	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056009072	salt bridge; other site
316056009073	non-specific DNA binding site [nucleotide binding]; other site
316056009074	sequence-specific DNA binding site [nucleotide binding]; other site
316056009075	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
316056009076	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056009077	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056009078	ligand binding site [chemical binding]; other site
316056009079	flexible hinge region; other site
316056009080	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
316056009081	putative switch regulator; other site
316056009082	non-specific DNA interactions [nucleotide binding]; other site
316056009083	DNA binding site [nucleotide binding]
316056009084	sequence specific DNA binding site [nucleotide binding]; other site
316056009085	putative cAMP binding site [chemical binding]; other site
316056009086	dihydroxy-acid dehydratase; Validated; Region: PRK06131
316056009087	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
316056009088	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
316056009089	NAD binding site [chemical binding]; other site
316056009090	catalytic residues [active]
316056009091	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
316056009092	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316056009093	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316056009094	active site
316056009095	catalytic tetrad [active]
316056009096	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
316056009097	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
316056009098	dimer interface [polypeptide binding]; other site
316056009099	active site
316056009100	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
316056009101	Beta-lactamase; Region: Beta-lactamase; pfam00144
316056009102	enoyl-CoA hydratase; Provisional; Region: PRK05995
316056009103	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056009104	substrate binding site [chemical binding]; other site
316056009105	oxyanion hole (OAH) forming residues; other site
316056009106	trimer interface [polypeptide binding]; other site
316056009107	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
316056009108	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
316056009109	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
316056009110	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
316056009111	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
316056009112	carboxyltransferase (CT) interaction site; other site
316056009113	biotinylation site [posttranslational modification]; other site
316056009114	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
316056009115	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
316056009116	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
316056009117	acyl-CoA synthetase; Validated; Region: PRK08316
316056009118	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056009119	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
316056009120	acyl-activating enzyme (AAE) consensus motif; other site
316056009121	acyl-activating enzyme (AAE) consensus motif; other site
316056009122	putative AMP binding site [chemical binding]; other site
316056009123	putative active site [active]
316056009124	putative CoA binding site [chemical binding]; other site
316056009125	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
316056009126	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
316056009127	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
316056009128	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
316056009129	putative C-terminal domain interface [polypeptide binding]; other site
316056009130	putative GSH binding site (G-site) [chemical binding]; other site
316056009131	putative dimer interface [polypeptide binding]; other site
316056009132	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
316056009133	N-terminal domain interface [polypeptide binding]; other site
316056009134	dimer interface [polypeptide binding]; other site
316056009135	substrate binding pocket (H-site) [chemical binding]; other site
316056009136	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
316056009137	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
316056009138	active site
316056009139	Cytochrome c; Region: Cytochrom_C; cl11414
316056009140	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056009141	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056009142	dimer interface [polypeptide binding]; other site
316056009143	phosphorylation site [posttranslational modification]
316056009144	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056009145	ATP binding site [chemical binding]; other site
316056009146	G-X-G motif; other site
316056009147	Response regulator receiver domain; Region: Response_reg; pfam00072
316056009148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056009149	active site
316056009150	phosphorylation site [posttranslational modification]
316056009151	intermolecular recognition site; other site
316056009152	dimerization interface [polypeptide binding]; other site
316056009153	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
316056009154	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
316056009155	putative ADP-binding pocket [chemical binding]; other site
316056009156	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
316056009157	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316056009158	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056009159	Walker A/P-loop; other site
316056009160	ATP binding site [chemical binding]; other site
316056009161	Q-loop/lid; other site
316056009162	ABC transporter signature motif; other site
316056009163	Walker B; other site
316056009164	D-loop; other site
316056009165	H-loop/switch region; other site
316056009166	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
316056009167	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
316056009168	PRC-barrel domain; Region: PRC; pfam05239
316056009169	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316056009170	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056009171	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
316056009172	Predicted periplasmic protein [Function unknown]; Region: COG3904
316056009173	SOUL heme-binding protein; Region: SOUL; pfam04832
316056009174	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316056009175	putative DNA binding site [nucleotide binding]; other site
316056009176	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
316056009177	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056009178	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056009179	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056009180	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316056009181	dimerization interface [polypeptide binding]; other site
316056009182	putative DNA binding site [nucleotide binding]; other site
316056009183	putative Zn2+ binding site [ion binding]; other site
316056009184	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
316056009185	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
316056009186	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
316056009187	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
316056009188	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
316056009189	[2Fe-2S] cluster binding site [ion binding]; other site
316056009190	Predicted transcriptional regulators [Transcription]; Region: COG1695
316056009191	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
316056009192	Helix-turn-helix domain; Region: HTH_18; pfam12833
316056009193	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316056009194	Domain of unknown function (DUF4410); Region: DUF4410; pfam14366
316056009195	DctM-like transporters; Region: DctM; pfam06808
316056009196	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
316056009197	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
316056009198	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
316056009199	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
316056009200	2-isopropylmalate synthase; Validated; Region: PRK00915
316056009201	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
316056009202	active site
316056009203	catalytic residues [active]
316056009204	metal binding site [ion binding]; metal-binding site
316056009205	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
316056009206	biotin synthase; Region: bioB; TIGR00433
316056009207	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056009208	FeS/SAM binding site; other site
316056009209	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
316056009210	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
316056009211	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
316056009212	nudix motif; other site
316056009213	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056009214	FeS/SAM binding site; other site
316056009215	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
316056009216	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056009217	Walker A/P-loop; other site
316056009218	ATP binding site [chemical binding]; other site
316056009219	Q-loop/lid; other site
316056009220	ABC transporter signature motif; other site
316056009221	Walker B; other site
316056009222	D-loop; other site
316056009223	H-loop/switch region; other site
316056009224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056009225	putative PBP binding loops; other site
316056009226	ABC-ATPase subunit interface; other site
316056009227	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
316056009228	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
316056009229	Sulfatase; Region: Sulfatase; cl17466
316056009230	short chain dehydrogenase; Validated; Region: PRK06182
316056009231	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
316056009232	NADP binding site [chemical binding]; other site
316056009233	active site
316056009234	steroid binding site; other site
316056009235	ketol-acid reductoisomerase; Provisional; Region: PRK05479
316056009236	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
316056009237	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
316056009238	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
316056009239	EamA-like transporter family; Region: EamA; pfam00892
316056009240	PemK-like protein; Region: PemK; pfam02452
316056009241	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
316056009242	Protein required for attachment to host cells; Region: Host_attach; pfam10116
316056009243	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
316056009244	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
316056009245	putative valine binding site [chemical binding]; other site
316056009246	dimer interface [polypeptide binding]; other site
316056009247	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
316056009248	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
316056009249	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
316056009250	tetramer interface [polypeptide binding]; other site
316056009251	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056009252	catalytic residue [active]
316056009253	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
316056009254	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
316056009255	PYR/PP interface [polypeptide binding]; other site
316056009256	dimer interface [polypeptide binding]; other site
316056009257	TPP binding site [chemical binding]; other site
316056009258	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
316056009259	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
316056009260	TPP-binding site [chemical binding]; other site
316056009261	dimer interface [polypeptide binding]; other site
316056009262	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
316056009263	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
316056009264	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
316056009265	Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; Region: HAD-SF-IB; TIGR01488
316056009266	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
316056009267	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
316056009268	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
316056009269	protein binding site [polypeptide binding]; other site
316056009270	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
316056009271	protein binding site [polypeptide binding]; other site
316056009272	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
316056009273	HflC protein; Region: hflC; TIGR01932
316056009274	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
316056009275	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
316056009276	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
316056009277	HflK protein; Region: hflK; TIGR01933
316056009278	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
316056009279	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
316056009280	folate binding site [chemical binding]; other site
316056009281	NADP+ binding site [chemical binding]; other site
316056009282	thymidylate synthase; Reviewed; Region: thyA; PRK01827
316056009283	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
316056009284	dimerization interface [polypeptide binding]; other site
316056009285	active site
316056009286	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
316056009287	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
316056009288	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
316056009289	Stringent starvation protein B; Region: SspB; pfam04386
316056009290	fumarate hydratase; Reviewed; Region: fumC; PRK00485
316056009291	Class II fumarases; Region: Fumarase_classII; cd01362
316056009292	active site
316056009293	tetramer interface [polypeptide binding]; other site
316056009294	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
316056009295	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
316056009296	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
316056009297	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
316056009298	Transposase; Region: DEDD_Tnp_IS110; pfam01548
316056009299	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
316056009300	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
316056009301	FAD binding domain; Region: FAD_binding_4; pfam01565
316056009302	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
316056009303	active site
316056009304	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
316056009305	Part of AAA domain; Region: AAA_19; pfam13245
316056009306	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
316056009307	Family description; Region: UvrD_C_2; pfam13538
316056009308	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
316056009309	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
316056009310	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
316056009311	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316056009312	Walker A/P-loop; other site
316056009313	ATP binding site [chemical binding]; other site
316056009314	Q-loop/lid; other site
316056009315	ABC transporter signature motif; other site
316056009316	Walker B; other site
316056009317	D-loop; other site
316056009318	H-loop/switch region; other site
316056009319	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316056009320	ABC-2 type transporter; Region: ABC2_membrane; cl17235
316056009321	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316056009322	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056009323	S-adenosylmethionine binding site [chemical binding]; other site
316056009324	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
316056009325	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
316056009326	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
316056009327	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056009328	S-adenosylmethionine binding site [chemical binding]; other site
316056009329	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
316056009330	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
316056009331	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
316056009332	active site
316056009333	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056009334	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
316056009335	putative substrate translocation pore; other site
316056009336	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
316056009337	active site
316056009338	catalytic site [active]
316056009339	substrate binding site [chemical binding]; other site
316056009340	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
316056009341	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
316056009342	nucleotide binding pocket [chemical binding]; other site
316056009343	K-X-D-G motif; other site
316056009344	catalytic site [active]
316056009345	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
316056009346	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
316056009347	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
316056009348	Dimer interface [polypeptide binding]; other site
316056009349	BRCT sequence motif; other site
316056009350	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
316056009351	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
316056009352	Walker A/P-loop; other site
316056009353	ATP binding site [chemical binding]; other site
316056009354	Q-loop/lid; other site
316056009355	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
316056009356	ABC transporter signature motif; other site
316056009357	Walker B; other site
316056009358	D-loop; other site
316056009359	H-loop/switch region; other site
316056009360	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
316056009361	Tetratricopeptide repeat; Region: TPR_6; pfam13174
316056009362	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
316056009363	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
316056009364	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
316056009365	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
316056009366	nucleotide binding site [chemical binding]; other site
316056009367	SulA interaction site; other site
316056009368	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
316056009369	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
316056009370	Cell division protein FtsA; Region: FtsA; smart00842
316056009371	Cell division protein FtsA; Region: FtsA; pfam14450
316056009372	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
316056009373	Cell division protein FtsQ; Region: FtsQ; pfam03799
316056009374	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
316056009375	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
316056009376	ATP-grasp domain; Region: ATP-grasp_4; cl17255
316056009377	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316056009378	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
316056009379	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
316056009380	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
316056009381	FAD binding domain; Region: FAD_binding_4; pfam01565
316056009382	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
316056009383	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
316056009384	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
316056009385	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
316056009386	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
316056009387	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
316056009388	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
316056009389	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
316056009390	active site
316056009391	homodimer interface [polypeptide binding]; other site
316056009392	cell division protein FtsW; Region: ftsW; TIGR02614
316056009393	response regulator PleD; Reviewed; Region: pleD; PRK09581
316056009394	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056009395	active site
316056009396	phosphorylation site [posttranslational modification]
316056009397	intermolecular recognition site; other site
316056009398	dimerization interface [polypeptide binding]; other site
316056009399	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056009400	active site
316056009401	phosphorylation site [posttranslational modification]
316056009402	intermolecular recognition site; other site
316056009403	dimerization interface [polypeptide binding]; other site
316056009404	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056009405	metal binding site [ion binding]; metal-binding site
316056009406	active site
316056009407	I-site; other site
316056009408	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
316056009409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056009410	active site
316056009411	phosphorylation site [posttranslational modification]
316056009412	intermolecular recognition site; other site
316056009413	dimerization interface [polypeptide binding]; other site
316056009414	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
316056009415	DNA polymerase IV; Provisional; Region: PRK02794
316056009416	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
316056009417	active site
316056009418	DNA binding site [nucleotide binding]
316056009419	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
316056009420	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
316056009421	homotrimer interaction site [polypeptide binding]; other site
316056009422	putative active site [active]
316056009423	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
316056009424	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
316056009425	putative active site [active]
316056009426	catalytic site [active]
316056009427	putative metal binding site [ion binding]; other site
316056009428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
316056009429	Protein of unknown function, DUF482; Region: DUF482; pfam04339
316056009430	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
316056009431	HIT family signature motif; other site
316056009432	catalytic residue [active]
316056009433	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
316056009434	homodimer interaction site [polypeptide binding]; other site
316056009435	cofactor binding site; other site
316056009436	AzlC protein; Region: AzlC; pfam03591
316056009437	PilZ domain; Region: PilZ; pfam07238
316056009438	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
316056009439	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316056009440	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316056009441	catalytic residue [active]
316056009442	Sporulation related domain; Region: SPOR; pfam05036
316056009443	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
316056009444	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
316056009445	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
316056009446	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056009447	Walker A motif; other site
316056009448	ATP binding site [chemical binding]; other site
316056009449	Walker B motif; other site
316056009450	arginine finger; other site
316056009451	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056009452	Walker A motif; other site
316056009453	ATP binding site [chemical binding]; other site
316056009454	Walker B motif; other site
316056009455	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
316056009456	Uncharacterized conserved protein [Function unknown]; Region: COG2127
316056009457	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
316056009458	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
316056009459	Phasin protein; Region: Phasin_2; pfam09361
316056009460	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
316056009461	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
316056009462	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
316056009463	HSP70 interaction site [polypeptide binding]; other site
316056009464	von Willebrand factor type A domain; Region: VWA_2; pfam13519
316056009465	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
316056009466	pantoate--beta-alanine ligase; Region: panC; TIGR00018
316056009467	Pantoate-beta-alanine ligase; Region: PanC; cd00560
316056009468	active site
316056009469	ATP-binding site [chemical binding]; other site
316056009470	pantoate-binding site; other site
316056009471	HXXH motif; other site
316056009472	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
316056009473	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
316056009474	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
316056009475	putative C-terminal domain interface [polypeptide binding]; other site
316056009476	putative GSH binding site (G-site) [chemical binding]; other site
316056009477	putative dimer interface [polypeptide binding]; other site
316056009478	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
316056009479	putative N-terminal domain interface [polypeptide binding]; other site
316056009480	putative substrate binding pocket (H-site) [chemical binding]; other site
316056009481	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
316056009482	Uncharacterized conserved protein [Function unknown]; Region: COG1434
316056009483	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
316056009484	putative active site [active]
316056009485	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316056009486	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316056009487	active site
316056009488	catalytic tetrad [active]
316056009489	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
316056009490	MgtE intracellular N domain; Region: MgtE_N; smart00924
316056009491	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
316056009492	Divalent cation transporter; Region: MgtE; pfam01769
316056009493	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
316056009494	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
316056009495	NodB motif; other site
316056009496	active site
316056009497	catalytic site [active]
316056009498	metal binding site [ion binding]; metal-binding site
316056009499	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
316056009500	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
316056009501	NodB motif; other site
316056009502	active site
316056009503	catalytic site [active]
316056009504	metal binding site [ion binding]; metal-binding site
316056009505	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
316056009506	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
316056009507	oligomeric interface; other site
316056009508	putative active site [active]
316056009509	homodimer interface [polypeptide binding]; other site
316056009510	hypothetical protein; Validated; Region: PRK06033
316056009511	lipoate-protein ligase B; Provisional; Region: PRK14341
316056009512	acylphosphatase; Provisional; Region: PRK14421
316056009513	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
316056009514	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
316056009515	tetramer interface [polypeptide binding]; other site
316056009516	active site
316056009517	Mg2+/Mn2+ binding site [ion binding]; other site
316056009518	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
316056009519	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
316056009520	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
316056009521	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
316056009522	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
316056009523	carboxyltransferase (CT) interaction site; other site
316056009524	biotinylation site [posttranslational modification]; other site
316056009525	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
316056009526	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
316056009527	DNA photolyase; Region: DNA_photolyase; pfam00875
316056009528	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
316056009529	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
316056009530	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056009531	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056009532	metal binding site [ion binding]; metal-binding site
316056009533	active site
316056009534	I-site; other site
316056009535	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
316056009536	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
316056009537	active site
316056009538	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
316056009539	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
316056009540	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056009541	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
316056009542	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
316056009543	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316056009544	catalytic residue [active]
316056009545	Condensation domain; Region: Condensation; pfam00668
316056009546	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
316056009547	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
316056009548	acyl-activating enzyme (AAE) consensus motif; other site
316056009549	AMP binding site [chemical binding]; other site
316056009550	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056009551	Condensation domain; Region: Condensation; pfam00668
316056009552	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
316056009553	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
316056009554	AMP-binding enzyme; Region: AMP-binding; pfam00501
316056009555	acyl-activating enzyme (AAE) consensus motif; other site
316056009556	active site
316056009557	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
316056009558	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
316056009559	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316056009560	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056009561	Walker A/P-loop; other site
316056009562	ATP binding site [chemical binding]; other site
316056009563	Q-loop/lid; other site
316056009564	ABC transporter signature motif; other site
316056009565	Walker B; other site
316056009566	D-loop; other site
316056009567	H-loop/switch region; other site
316056009568	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056009569	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056009570	ligand binding site [chemical binding]; other site
316056009571	flexible hinge region; other site
316056009572	Thioesterase domain; Region: Thioesterase; pfam00975
316056009573	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
316056009574	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
316056009575	Condensation domain; Region: Condensation; pfam00668
316056009576	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
316056009577	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
316056009578	acyl-activating enzyme (AAE) consensus motif; other site
316056009579	AMP binding site [chemical binding]; other site
316056009580	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056009581	Condensation domain; Region: Condensation; pfam00668
316056009582	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316056009583	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
316056009584	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
316056009585	acyl-activating enzyme (AAE) consensus motif; other site
316056009586	AMP binding site [chemical binding]; other site
316056009587	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
316056009588	Condensation domain; Region: Condensation; pfam00668
316056009589	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
316056009590	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
316056009591	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
316056009592	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056009593	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056009594	multidrug efflux protein; Reviewed; Region: PRK09579
316056009595	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
316056009596	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
316056009597	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
316056009598	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056009599	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056009600	ligand binding site [chemical binding]; other site
316056009601	flexible hinge region; other site
316056009602	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
316056009603	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
316056009604	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
316056009605	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056009606	dimer interface [polypeptide binding]; other site
316056009607	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
316056009608	putative CheW interface [polypeptide binding]; other site
316056009609	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
316056009610	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056009611	dimer interface [polypeptide binding]; other site
316056009612	putative CheW interface [polypeptide binding]; other site
316056009613	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
316056009614	dimerization interface [polypeptide binding]; other site
316056009615	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056009616	dimer interface [polypeptide binding]; other site
316056009617	putative CheW interface [polypeptide binding]; other site
316056009618	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
316056009619	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056009620	dimerization interface [polypeptide binding]; other site
316056009621	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056009622	dimer interface [polypeptide binding]; other site
316056009623	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
316056009624	putative CheW interface [polypeptide binding]; other site
316056009625	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
316056009626	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
316056009627	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
316056009628	PAS domain S-box; Region: sensory_box; TIGR00229
316056009629	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056009630	putative active site [active]
316056009631	heme pocket [chemical binding]; other site
316056009632	PAS fold; Region: PAS_4; pfam08448
316056009633	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056009634	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056009635	ATP binding site [chemical binding]; other site
316056009636	Mg2+ binding site [ion binding]; other site
316056009637	G-X-G motif; other site
316056009638	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
316056009639	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
316056009640	inhibitor site; inhibition site
316056009641	active site
316056009642	dimer interface [polypeptide binding]; other site
316056009643	catalytic residue [active]
316056009644	enoyl-CoA hydratase; Region: PLN02864
316056009645	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
316056009646	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
316056009647	dimer interaction site [polypeptide binding]; other site
316056009648	substrate-binding tunnel; other site
316056009649	active site
316056009650	catalytic site [active]
316056009651	substrate binding site [chemical binding]; other site
316056009652	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
316056009653	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
316056009654	dimer interface [polypeptide binding]; other site
316056009655	PYR/PP interface [polypeptide binding]; other site
316056009656	TPP binding site [chemical binding]; other site
316056009657	substrate binding site [chemical binding]; other site
316056009658	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
316056009659	TPP-binding site [chemical binding]; other site
316056009660	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
316056009661	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
316056009662	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
316056009663	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
316056009664	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056009665	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056009666	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
316056009667	Methyltransferase domain; Region: Methyltransf_24; pfam13578
316056009668	Fic/DOC family; Region: Fic; pfam02661
316056009669	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
316056009670	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
316056009671	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
316056009672	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
316056009673	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
316056009674	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
316056009675	ATP12 chaperone protein; Region: ATP12; cl02228
316056009676	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
316056009677	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
316056009678	RNA binding surface [nucleotide binding]; other site
316056009679	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
316056009680	active site
316056009681	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
316056009682	Sensors of blue-light using FAD; Region: BLUF; pfam04940
316056009683	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056009684	S-adenosylmethionine binding site [chemical binding]; other site
316056009685	hypothetical protein; Provisional; Region: PRK12472
316056009686	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316056009687	Uncharacterized conserved protein [Function unknown]; Region: COG0432
316056009688	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
316056009689	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
316056009690	putative NAD(P) binding site [chemical binding]; other site
316056009691	putative substrate binding site [chemical binding]; other site
316056009692	catalytic Zn binding site [ion binding]; other site
316056009693	structural Zn binding site [ion binding]; other site
316056009694	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
316056009695	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
316056009696	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
316056009697	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
316056009698	putative active site [active]
316056009699	catalytic site [active]
316056009700	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128
316056009701	PLD-like domain; Region: PLDc_2; pfam13091
316056009702	putative active site [active]
316056009703	putative catalytic site [active]
316056009704	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
316056009705	recombination factor protein RarA; Reviewed; Region: PRK13342
316056009706	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056009707	Walker A motif; other site
316056009708	ATP binding site [chemical binding]; other site
316056009709	Walker B motif; other site
316056009710	arginine finger; other site
316056009711	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
316056009712	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
316056009713	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
316056009714	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
316056009715	protein binding site [polypeptide binding]; other site
316056009716	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
316056009717	protein binding site [polypeptide binding]; other site
316056009718	Predicted transcriptional regulators [Transcription]; Region: COG1733
316056009719	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
316056009720	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
316056009721	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
316056009722	putative NAD(P) binding site [chemical binding]; other site
316056009723	dimer interface [polypeptide binding]; other site
316056009724	Uncharacterized conserved protein [Function unknown]; Region: COG3791
316056009725	short chain dehydrogenase; Provisional; Region: PRK06523
316056009726	classical (c) SDRs; Region: SDR_c; cd05233
316056009727	NAD(P) binding site [chemical binding]; other site
316056009728	active site
316056009729	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
316056009730	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
316056009731	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
316056009732	alphaNTD - beta interaction site [polypeptide binding]; other site
316056009733	alphaNTD homodimer interface [polypeptide binding]; other site
316056009734	alphaNTD - beta' interaction site [polypeptide binding]; other site
316056009735	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
316056009736	30S ribosomal protein S11; Validated; Region: PRK05309
316056009737	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
316056009738	30S ribosomal protein S13; Region: bact_S13; TIGR03631
316056009739	adenylate kinase; Reviewed; Region: adk; PRK00279
316056009740	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
316056009741	AMP-binding site [chemical binding]; other site
316056009742	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
316056009743	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
316056009744	SecY translocase; Region: SecY; pfam00344
316056009745	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
316056009746	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
316056009747	23S rRNA binding site [nucleotide binding]; other site
316056009748	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
316056009749	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
316056009750	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
316056009751	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
316056009752	5S rRNA interface [nucleotide binding]; other site
316056009753	23S rRNA interface [nucleotide binding]; other site
316056009754	L5 interface [polypeptide binding]; other site
316056009755	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
316056009756	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
316056009757	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
316056009758	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
316056009759	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
316056009760	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
316056009761	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
316056009762	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
316056009763	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
316056009764	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
316056009765	RNA binding site [nucleotide binding]; other site
316056009766	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
316056009767	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
316056009768	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
316056009769	23S rRNA interface [nucleotide binding]; other site
316056009770	putative translocon interaction site; other site
316056009771	signal recognition particle (SRP54) interaction site; other site
316056009772	L23 interface [polypeptide binding]; other site
316056009773	trigger factor interaction site; other site
316056009774	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
316056009775	23S rRNA interface [nucleotide binding]; other site
316056009776	5S rRNA interface [nucleotide binding]; other site
316056009777	putative antibiotic binding site [chemical binding]; other site
316056009778	L25 interface [polypeptide binding]; other site
316056009779	L27 interface [polypeptide binding]; other site
316056009780	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
316056009781	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
316056009782	G-X-X-G motif; other site
316056009783	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
316056009784	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
316056009785	putative translocon binding site; other site
316056009786	protein-rRNA interface [nucleotide binding]; other site
316056009787	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
316056009788	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
316056009789	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
316056009790	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
316056009791	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
316056009792	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
316056009793	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
316056009794	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
316056009795	elongation factor Tu; Reviewed; Region: PRK00049
316056009796	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
316056009797	G1 box; other site
316056009798	GEF interaction site [polypeptide binding]; other site
316056009799	GTP/Mg2+ binding site [chemical binding]; other site
316056009800	Switch I region; other site
316056009801	G2 box; other site
316056009802	G3 box; other site
316056009803	Switch II region; other site
316056009804	G4 box; other site
316056009805	G5 box; other site
316056009806	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
316056009807	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
316056009808	Antibiotic Binding Site [chemical binding]; other site
316056009809	elongation factor G; Reviewed; Region: PRK00007
316056009810	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
316056009811	G1 box; other site
316056009812	putative GEF interaction site [polypeptide binding]; other site
316056009813	GTP/Mg2+ binding site [chemical binding]; other site
316056009814	Switch I region; other site
316056009815	G2 box; other site
316056009816	G3 box; other site
316056009817	Switch II region; other site
316056009818	G4 box; other site
316056009819	G5 box; other site
316056009820	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
316056009821	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
316056009822	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
316056009823	30S ribosomal protein S7; Validated; Region: PRK05302
316056009824	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
316056009825	S17 interaction site [polypeptide binding]; other site
316056009826	S8 interaction site; other site
316056009827	16S rRNA interaction site [nucleotide binding]; other site
316056009828	streptomycin interaction site [chemical binding]; other site
316056009829	23S rRNA interaction site [nucleotide binding]; other site
316056009830	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
316056009831	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
316056009832	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316056009833	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
316056009834	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056009835	Walker A/P-loop; other site
316056009836	ATP binding site [chemical binding]; other site
316056009837	Q-loop/lid; other site
316056009838	ABC transporter signature motif; other site
316056009839	Walker B; other site
316056009840	D-loop; other site
316056009841	H-loop/switch region; other site
316056009842	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
316056009843	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
316056009844	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056009845	S-adenosylmethionine binding site [chemical binding]; other site
316056009846	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
316056009847	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
316056009848	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
316056009849	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
316056009850	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
316056009851	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
316056009852	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
316056009853	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
316056009854	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
316056009855	DNA binding site [nucleotide binding]
316056009856	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
316056009857	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
316056009858	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
316056009859	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
316056009860	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
316056009861	RPB11 interaction site [polypeptide binding]; other site
316056009862	RPB12 interaction site [polypeptide binding]; other site
316056009863	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
316056009864	RPB3 interaction site [polypeptide binding]; other site
316056009865	RPB1 interaction site [polypeptide binding]; other site
316056009866	RPB11 interaction site [polypeptide binding]; other site
316056009867	RPB10 interaction site [polypeptide binding]; other site
316056009868	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
316056009869	L11 interface [polypeptide binding]; other site
316056009870	putative EF-Tu interaction site [polypeptide binding]; other site
316056009871	putative EF-G interaction site [polypeptide binding]; other site
316056009872	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
316056009873	23S rRNA interface [nucleotide binding]; other site
316056009874	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
316056009875	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
316056009876	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
316056009877	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
316056009878	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
316056009879	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
316056009880	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
316056009881	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316056009882	catalytic loop [active]
316056009883	iron binding site [ion binding]; other site
316056009884	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
316056009885	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
316056009886	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
316056009887	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056009888	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
316056009889	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
316056009890	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
316056009891	putative ligand binding site [chemical binding]; other site
316056009892	NAD binding site [chemical binding]; other site
316056009893	catalytic site [active]
316056009894	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
316056009895	mRNA/rRNA interface [nucleotide binding]; other site
316056009896	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
316056009897	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
316056009898	23S rRNA interface [nucleotide binding]; other site
316056009899	L7/L12 interface [polypeptide binding]; other site
316056009900	putative thiostrepton binding site; other site
316056009901	L25 interface [polypeptide binding]; other site
316056009902	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
316056009903	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
316056009904	putative homodimer interface [polypeptide binding]; other site
316056009905	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
316056009906	heterodimer interface [polypeptide binding]; other site
316056009907	homodimer interface [polypeptide binding]; other site
316056009908	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
316056009909	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056009910	dimerization interface [polypeptide binding]; other site
316056009911	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
316056009912	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056009913	dimer interface [polypeptide binding]; other site
316056009914	putative CheW interface [polypeptide binding]; other site
316056009915	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
316056009916	dimerization interface [polypeptide binding]; other site
316056009917	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056009918	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056009919	dimer interface [polypeptide binding]; other site
316056009920	putative CheW interface [polypeptide binding]; other site
316056009921	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
316056009922	Beta-lactamase; Region: Beta-lactamase; pfam00144
316056009923	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
316056009924	classical (c) SDRs; Region: SDR_c; cd05233
316056009925	NAD(P) binding site [chemical binding]; other site
316056009926	active site
316056009927	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
316056009928	catalytic core [active]
316056009929	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
316056009930	classical (c) SDRs; Region: SDR_c; cd05233
316056009931	NAD(P) binding site [chemical binding]; other site
316056009932	active site
316056009933	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
316056009934	Phosphotransferase enzyme family; Region: APH; pfam01636
316056009935	putative active site [active]
316056009936	putative substrate binding site [chemical binding]; other site
316056009937	ATP binding site [chemical binding]; other site
316056009938	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
316056009939	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
316056009940	active site
316056009941	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
316056009942	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056009943	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
316056009944	Beta-lactamase; Region: Beta-lactamase; pfam00144
316056009945	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
316056009946	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
316056009947	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316056009948	Walker A/P-loop; other site
316056009949	ATP binding site [chemical binding]; other site
316056009950	Q-loop/lid; other site
316056009951	ABC transporter signature motif; other site
316056009952	Walker B; other site
316056009953	D-loop; other site
316056009954	H-loop/switch region; other site
316056009955	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316056009956	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316056009957	Walker A/P-loop; other site
316056009958	ATP binding site [chemical binding]; other site
316056009959	Q-loop/lid; other site
316056009960	ABC transporter signature motif; other site
316056009961	Walker B; other site
316056009962	D-loop; other site
316056009963	H-loop/switch region; other site
316056009964	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316056009965	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
316056009966	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056009967	dimer interface [polypeptide binding]; other site
316056009968	conserved gate region; other site
316056009969	putative PBP binding loops; other site
316056009970	ABC-ATPase subunit interface; other site
316056009971	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
316056009972	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056009973	dimer interface [polypeptide binding]; other site
316056009974	conserved gate region; other site
316056009975	putative PBP binding loops; other site
316056009976	ABC-ATPase subunit interface; other site
316056009977	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
316056009978	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
316056009979	hypothetical protein; Provisional; Region: PRK12474
316056009980	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
316056009981	PYR/PP interface [polypeptide binding]; other site
316056009982	dimer interface [polypeptide binding]; other site
316056009983	TPP binding site [chemical binding]; other site
316056009984	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
316056009985	TPP-binding site [chemical binding]; other site
316056009986	dimer interface [polypeptide binding]; other site
316056009987	acetylornithine deacetylase; Provisional; Region: PRK06837
316056009988	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
316056009989	metal binding site [ion binding]; metal-binding site
316056009990	dimer interface [polypeptide binding]; other site
316056009991	succinic semialdehyde dehydrogenase; Region: PLN02278
316056009992	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
316056009993	tetramerization interface [polypeptide binding]; other site
316056009994	NAD(P) binding site [chemical binding]; other site
316056009995	catalytic residues [active]
316056009996	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
316056009997	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
316056009998	inhibitor-cofactor binding pocket; inhibition site
316056009999	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056010000	catalytic residue [active]
316056010001	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
316056010002	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056010003	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
316056010004	dimerization interface [polypeptide binding]; other site
316056010005	Protein of unknown function (DUF763); Region: DUF763; pfam05559
316056010006	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
316056010007	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056010008	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316056010009	putative substrate translocation pore; other site
316056010010	Methyltransferase domain; Region: Methyltransf_24; pfam13578
316056010011	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
316056010012	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
316056010013	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056010014	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056010015	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
316056010016	putative substrate binding pocket [chemical binding]; other site
316056010017	putative dimerization interface [polypeptide binding]; other site
316056010018	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
316056010019	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
316056010020	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
316056010021	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
316056010022	metal binding site 2 [ion binding]; metal-binding site
316056010023	putative DNA binding helix; other site
316056010024	metal binding site 1 [ion binding]; metal-binding site
316056010025	dimer interface [polypeptide binding]; other site
316056010026	structural Zn2+ binding site [ion binding]; other site
316056010027	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
316056010028	Fe2+ transport protein; Region: Iron_transport; pfam10634
316056010029	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
316056010030	NAD binding site [chemical binding]; other site
316056010031	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
316056010032	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
316056010033	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
316056010034	THF binding site; other site
316056010035	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
316056010036	substrate binding site [chemical binding]; other site
316056010037	THF binding site; other site
316056010038	zinc-binding site [ion binding]; other site
316056010039	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
316056010040	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
316056010041	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
316056010042	tetramer interface [polypeptide binding]; other site
316056010043	active site
316056010044	Mg2+/Mn2+ binding site [ion binding]; other site
316056010045	methylcitrate synthase; Provisional; Region: PRK12351
316056010046	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
316056010047	oxalacetate binding site [chemical binding]; other site
316056010048	citrylCoA binding site [chemical binding]; other site
316056010049	coenzyme A binding site [chemical binding]; other site
316056010050	catalytic triad [active]
316056010051	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
316056010052	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
316056010053	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
316056010054	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056010055	non-specific DNA binding site [nucleotide binding]; other site
316056010056	salt bridge; other site
316056010057	sequence-specific DNA binding site [nucleotide binding]; other site
316056010058	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
316056010059	Domain of unknown function (DUF955); Region: DUF955; pfam06114
316056010060	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
316056010061	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056010062	FeS/SAM binding site; other site
316056010063	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
316056010064	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
316056010065	ATP cone domain; Region: ATP-cone; pfam03477
316056010066	Class III ribonucleotide reductase; Region: RNR_III; cd01675
316056010067	effector binding site; other site
316056010068	active site
316056010069	Zn binding site [ion binding]; other site
316056010070	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
316056010071	dimer interface [polypeptide binding]; other site
316056010072	putative radical transfer pathway; other site
316056010073	diiron center [ion binding]; other site
316056010074	tyrosyl radical; other site
316056010075	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
316056010076	ATP cone domain; Region: ATP-cone; pfam03477
316056010077	ATP cone domain; Region: ATP-cone; pfam03477
316056010078	Class I ribonucleotide reductase; Region: RNR_I; cd01679
316056010079	active site
316056010080	dimer interface [polypeptide binding]; other site
316056010081	catalytic residues [active]
316056010082	effector binding site; other site
316056010083	R2 peptide binding site; other site
316056010084	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
316056010085	active site 2 [active]
316056010086	active site 1 [active]
316056010087	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
316056010088	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
316056010089	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056010090	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056010091	metal binding site [ion binding]; metal-binding site
316056010092	active site
316056010093	I-site; other site
316056010094	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056010095	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056010096	metal binding site [ion binding]; metal-binding site
316056010097	active site
316056010098	I-site; other site
316056010099	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056010100	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
316056010101	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056010102	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
316056010103	dimerization interface [polypeptide binding]; other site
316056010104	substrate binding pocket [chemical binding]; other site
316056010105	PRC-barrel domain; Region: PRC; pfam05239
316056010106	GAF domain; Region: GAF; cl17456
316056010107	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
316056010108	Histidine kinase; Region: HisKA_2; pfam07568
316056010109	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056010110	ATP binding site [chemical binding]; other site
316056010111	Mg2+ binding site [ion binding]; other site
316056010112	G-X-G motif; other site
316056010113	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
316056010114	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
316056010115	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
316056010116	VirB7 interaction site; other site
316056010117	conjugal transfer protein TrbF; Provisional; Region: PRK13872
316056010118	conjugal transfer protein TrbL; Provisional; Region: PRK13875
316056010119	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
316056010120	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
316056010121	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
316056010122	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
316056010123	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
316056010124	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056010125	Walker A/P-loop; other site
316056010126	ATP binding site [chemical binding]; other site
316056010127	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056010128	Walker B; other site
316056010129	D-loop; other site
316056010130	H-loop/switch region; other site
316056010131	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
316056010132	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
316056010133	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
316056010134	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
316056010135	ATP binding site [chemical binding]; other site
316056010136	Walker A motif; other site
316056010137	hexamer interface [polypeptide binding]; other site
316056010138	Walker B motif; other site
316056010139	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
316056010140	Part of AAA domain; Region: AAA_19; pfam13245
316056010141	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
316056010142	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
316056010143	Walker B; other site
316056010144	D-loop; other site
316056010145	H-loop/switch region; other site
316056010146	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
316056010147	putative active site [active]
316056010148	putative metal-binding site [ion binding]; other site
316056010149	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
316056010150	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
316056010151	synthetase active site [active]
316056010152	NTP binding site [chemical binding]; other site
316056010153	metal binding site [ion binding]; metal-binding site
316056010154	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
316056010155	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
316056010156	Walker A motif; other site
316056010157	ATP binding site [chemical binding]; other site
316056010158	Walker B motif; other site
316056010159	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
316056010160	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056010161	non-specific DNA binding site [nucleotide binding]; other site
316056010162	salt bridge; other site
316056010163	sequence-specific DNA binding site [nucleotide binding]; other site
316056010164	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
316056010165	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
316056010166	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
316056010167	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
316056010168	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316056010169	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316056010170	catalytic residue [active]
316056010171	Protein of unknown function (DUF736); Region: DUF736; pfam05284
316056010172	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
316056010173	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
316056010174	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
316056010175	Replication initiator protein A; Region: RPA; pfam10134
316056010176	Helix-turn-helix domain; Region: HTH_17; pfam12728
316056010177	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
316056010178	Uncharacterized conserved protein [Function unknown]; Region: COG5489
316056010179	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
316056010180	Toprim domain; Region: Toprim_3; pfam13362
316056010181	Methyltransferase domain; Region: Methyltransf_26; pfam13659
316056010182	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
316056010183	Helicase_C-like; Region: Helicase_C_4; pfam13871
316056010184	ParB-like nuclease domain; Region: ParBc; pfam02195
316056010185	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
316056010186	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
316056010187	SEC-C motif; Region: SEC-C; pfam02810
316056010188	6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873
316056010189	Cell division protein 48 (CDC48), domain 2; Region: CDC48_2; pfam02933
316056010190	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056010191	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
316056010192	Walker A motif; other site
316056010193	ATP binding site [chemical binding]; other site
316056010194	Walker B motif; other site
316056010195	arginine finger; other site
316056010196	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056010197	Walker B motif; other site
316056010198	arginine finger; other site
316056010199	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056010200	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056010201	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316056010202	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
316056010203	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316056010204	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
316056010205	Walker A/P-loop; other site
316056010206	ATP binding site [chemical binding]; other site
316056010207	Q-loop/lid; other site
316056010208	ABC transporter signature motif; other site
316056010209	Walker B; other site
316056010210	D-loop; other site
316056010211	H-loop/switch region; other site
316056010212	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316056010213	Walker A/P-loop; other site
316056010214	ATP binding site [chemical binding]; other site
316056010215	Q-loop/lid; other site
316056010216	ABC transporter signature motif; other site
316056010217	Walker B; other site
316056010218	D-loop; other site
316056010219	H-loop/switch region; other site
316056010220	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316056010221	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
316056010222	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
316056010223	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056010224	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056010225	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
316056010226	active site
316056010227	nucleophile elbow; other site
316056010228	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
316056010229	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056010230	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056010231	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316056010232	Ligand Binding Site [chemical binding]; other site
316056010233	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316056010234	Ligand Binding Site [chemical binding]; other site
316056010235	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
316056010236	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
316056010237	Protein export membrane protein; Region: SecD_SecF; cl14618
316056010238	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056010239	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056010240	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056010241	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056010242	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056010243	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
316056010244	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
316056010245	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
316056010246	MarR family; Region: MarR; pfam01047
316056010247	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
316056010248	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
316056010249	putative C-terminal domain interface [polypeptide binding]; other site
316056010250	putative GSH binding site (G-site) [chemical binding]; other site
316056010251	putative dimer interface [polypeptide binding]; other site
316056010252	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
316056010253	putative N-terminal domain interface [polypeptide binding]; other site
316056010254	putative dimer interface [polypeptide binding]; other site
316056010255	putative substrate binding pocket (H-site) [chemical binding]; other site
316056010256	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
316056010257	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056010258	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056010259	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
316056010260	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056010261	putative substrate translocation pore; other site
316056010262	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056010263	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
316056010264	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056010265	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056010266	myosin-cross-reactive antigen; Provisional; Region: PRK13977
316056010267	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
316056010268	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
316056010269	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
316056010270	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
316056010271	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
316056010272	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
316056010273	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
316056010274	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
316056010275	GAF domain; Region: GAF; pfam01590
316056010276	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056010277	Walker A motif; other site
316056010278	ATP binding site [chemical binding]; other site
316056010279	Walker B motif; other site
316056010280	arginine finger; other site
316056010281	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316056010282	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316056010283	Ligand Binding Site [chemical binding]; other site
316056010284	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
316056010285	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
316056010286	Walker A/P-loop; other site
316056010287	ATP binding site [chemical binding]; other site
316056010288	Q-loop/lid; other site
316056010289	ABC transporter signature motif; other site
316056010290	Walker B; other site
316056010291	D-loop; other site
316056010292	H-loop/switch region; other site
316056010293	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
316056010294	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
316056010295	ABC-ATPase subunit  interface; other site
316056010296	dimer interface [polypeptide binding]; other site
316056010297	putative PBP binding regions; other site
316056010298	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
316056010299	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
316056010300	intersubunit interface [polypeptide binding]; other site
316056010301	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
316056010302	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
316056010303	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316056010304	N-terminal plug; other site
316056010305	ligand-binding site [chemical binding]; other site
316056010306	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
316056010307	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
316056010308	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
316056010309	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
316056010310	Soluble P-type ATPase [General function prediction only]; Region: COG4087
316056010311	Uncharacterized conserved protein [Function unknown]; Region: COG4095
316056010312	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
316056010313	dimerization interface [polypeptide binding]; other site
316056010314	metal binding site [ion binding]; metal-binding site
316056010315	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
316056010316	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
316056010317	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
316056010318	heme binding pocket [chemical binding]; other site
316056010319	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
316056010320	domain interactions; other site
316056010321	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
316056010322	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
316056010323	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
316056010324	active site
316056010325	catalytic site [active]
316056010326	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
316056010327	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
316056010328	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
316056010329	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
316056010330	4Fe-4S binding domain; Region: Fer4_5; pfam12801
316056010331	Iron permease FTR1 family; Region: FTR1; cl00475
316056010332	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
316056010333	Fe2+ transport protein; Region: Iron_transport; pfam10634
316056010334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056010335	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316056010336	putative substrate translocation pore; other site
316056010337	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316056010338	Ligand Binding Site [chemical binding]; other site
316056010339	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
316056010340	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316056010341	putative DNA binding site [nucleotide binding]; other site
316056010342	putative Zn2+ binding site [ion binding]; other site
316056010343	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
316056010344	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
316056010345	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316056010346	catalytic residue [active]
316056010347	serine O-acetyltransferase; Region: cysE; TIGR01172
316056010348	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
316056010349	trimer interface [polypeptide binding]; other site
316056010350	active site
316056010351	substrate binding site [chemical binding]; other site
316056010352	CoA binding site [chemical binding]; other site
316056010353	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
316056010354	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
316056010355	dimer interface [polypeptide binding]; other site
316056010356	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056010357	catalytic residue [active]
316056010358	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
316056010359	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
316056010360	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
316056010361	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
316056010362	Transposase; Region: DEDD_Tnp_IS110; pfam01548
316056010363	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
316056010364	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
316056010365	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
316056010366	putative NAD(P) binding site [chemical binding]; other site
316056010367	active site
316056010368	putative substrate binding site [chemical binding]; other site
316056010369	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
316056010370	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056010371	dimer interface [polypeptide binding]; other site
316056010372	conserved gate region; other site
316056010373	putative PBP binding loops; other site
316056010374	ABC-ATPase subunit interface; other site
316056010375	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056010376	dimer interface [polypeptide binding]; other site
316056010377	conserved gate region; other site
316056010378	putative PBP binding loops; other site
316056010379	ABC-ATPase subunit interface; other site
316056010380	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
316056010381	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
316056010382	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
316056010383	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
316056010384	Walker A/P-loop; other site
316056010385	ATP binding site [chemical binding]; other site
316056010386	Q-loop/lid; other site
316056010387	ABC transporter signature motif; other site
316056010388	Walker B; other site
316056010389	D-loop; other site
316056010390	H-loop/switch region; other site
316056010391	TOBE domain; Region: TOBE_2; pfam08402
316056010392	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
316056010393	short chain dehydrogenase; Provisional; Region: PRK06138
316056010394	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056010395	NAD(P) binding site [chemical binding]; other site
316056010396	active site
316056010397	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
316056010398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056010399	NAD(P) binding site [chemical binding]; other site
316056010400	active site
316056010401	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
316056010402	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
316056010403	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316056010404	ATP binding site [chemical binding]; other site
316056010405	putative Mg++ binding site [ion binding]; other site
316056010406	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316056010407	nucleotide binding region [chemical binding]; other site
316056010408	ATP-binding site [chemical binding]; other site
316056010409	HsdM N-terminal domain; Region: HsdM_N; pfam12161
316056010410	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
316056010411	Methyltransferase domain; Region: Methyltransf_26; pfam13659
316056010412	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
316056010413	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
316056010414	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
316056010415	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
316056010416	catalytic residues [active]
316056010417	catalytic nucleophile [active]
316056010418	Predicted periplasmic protein [Function unknown]; Region: COG3904
316056010419	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
316056010420	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
316056010421	active site
316056010422	DNA binding site [nucleotide binding]
316056010423	Int/Topo IB signature motif; other site
316056010424	Protein of unknown function (DUF3138); Region: DUF3138; pfam11336
316056010425	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
316056010426	GIY-YIG motif/motif A; other site
316056010427	putative active site [active]
316056010428	putative metal binding site [ion binding]; other site
316056010429	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
316056010430	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
316056010431	catalytic residues [active]
316056010432	dimer interface [polypeptide binding]; other site
316056010433	amidase; Provisional; Region: PRK07487
316056010434	Amidase; Region: Amidase; cl11426
316056010435	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
316056010436	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
316056010437	TAP-like protein; Region: Abhydrolase_4; pfam08386
316056010438	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
316056010439	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
316056010440	putative active site [active]
316056010441	catalytic residue [active]
316056010442	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
316056010443	active site
316056010444	dimer interface [polypeptide binding]; other site
316056010445	SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798
316056010446	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
316056010447	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
316056010448	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
316056010449	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
316056010450	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
316056010451	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
316056010452	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
316056010453	putative active site [active]
316056010454	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
316056010455	ATP-binding site [chemical binding]; other site
316056010456	Gluconate-6-phosphate binding site [chemical binding]; other site
316056010457	Shikimate kinase; Region: SKI; pfam01202
316056010458	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316056010459	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
316056010460	active site
316056010461	motif I; other site
316056010462	motif II; other site
316056010463	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
316056010464	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
316056010465	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
316056010466	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
316056010467	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
316056010468	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
316056010469	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
316056010470	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
316056010471	active site
316056010472	homodimer interface [polypeptide binding]; other site
316056010473	catalytic site [active]
316056010474	acceptor binding site [chemical binding]; other site
316056010475	trehalose synthase; Region: treS_nterm; TIGR02456
316056010476	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
316056010477	active site
316056010478	catalytic site [active]
316056010479	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
316056010480	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
316056010481	glycogen branching enzyme; Provisional; Region: PRK05402
316056010482	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
316056010483	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
316056010484	active site
316056010485	catalytic site [active]
316056010486	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
316056010487	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
316056010488	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
316056010489	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
316056010490	active site
316056010491	catalytic site [active]
316056010492	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
316056010493	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
316056010494	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
316056010495	active site
316056010496	catalytic site [active]
316056010497	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
316056010498	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
316056010499	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
316056010500	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
316056010501	active site
316056010502	DNA binding site [nucleotide binding]
316056010503	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
316056010504	DNA binding site [nucleotide binding]
316056010505	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
316056010506	nucleotide binding site [chemical binding]; other site
316056010507	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
316056010508	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
316056010509	putative DNA binding site [nucleotide binding]; other site
316056010510	putative homodimer interface [polypeptide binding]; other site
316056010511	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
316056010512	CPxP  motif; other site
316056010513	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
316056010514	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
316056010515	GTP binding site; other site
316056010516	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
316056010517	UreF; Region: UreF; pfam01730
316056010518	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
316056010519	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
316056010520	dimer interface [polypeptide binding]; other site
316056010521	catalytic residues [active]
316056010522	urease subunit alpha; Reviewed; Region: ureC; PRK13207
316056010523	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
316056010524	subunit interactions [polypeptide binding]; other site
316056010525	active site
316056010526	flap region; other site
316056010527	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
316056010528	putative active site [active]
316056010529	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
316056010530	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
316056010531	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
316056010532	gamma-beta subunit interface [polypeptide binding]; other site
316056010533	alpha-beta subunit interface [polypeptide binding]; other site
316056010534	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
316056010535	alpha-gamma subunit interface [polypeptide binding]; other site
316056010536	beta-gamma subunit interface [polypeptide binding]; other site
316056010537	UreD urease accessory protein; Region: UreD; pfam01774
316056010538	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
316056010539	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316056010540	Walker A/P-loop; other site
316056010541	ATP binding site [chemical binding]; other site
316056010542	Q-loop/lid; other site
316056010543	ABC transporter signature motif; other site
316056010544	Walker B; other site
316056010545	D-loop; other site
316056010546	H-loop/switch region; other site
316056010547	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
316056010548	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316056010549	Walker A/P-loop; other site
316056010550	ATP binding site [chemical binding]; other site
316056010551	Q-loop/lid; other site
316056010552	ABC transporter signature motif; other site
316056010553	Walker B; other site
316056010554	D-loop; other site
316056010555	H-loop/switch region; other site
316056010556	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
316056010557	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316056010558	TM-ABC transporter signature motif; other site
316056010559	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316056010560	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316056010561	TM-ABC transporter signature motif; other site
316056010562	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
316056010563	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
316056010564	putative ligand binding site [chemical binding]; other site
316056010565	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
316056010566	DEAD-like helicases superfamily; Region: DEXDc; smart00487
316056010567	ATP binding site [chemical binding]; other site
316056010568	Mg++ binding site [ion binding]; other site
316056010569	motif III; other site
316056010570	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316056010571	nucleotide binding region [chemical binding]; other site
316056010572	ATP-binding site [chemical binding]; other site
316056010573	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
316056010574	rRNA binding site [nucleotide binding]; other site
316056010575	predicted 30S ribosome binding site; other site
316056010576	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
316056010577	DNA-binding site [nucleotide binding]; DNA binding site
316056010578	RNA-binding motif; other site
316056010579	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
316056010580	TadE-like protein; Region: TadE; pfam07811
316056010581	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
316056010582	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
316056010583	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
316056010584	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
316056010585	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
316056010586	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
316056010587	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
316056010588	BON domain; Region: BON; pfam04972
316056010589	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
316056010590	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
316056010591	Type IV pili component [Cell motility and secretion]; Region: COG5461
316056010592	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
316056010593	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
316056010594	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
316056010595	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
316056010596	ATP binding site [chemical binding]; other site
316056010597	Walker A motif; other site
316056010598	hexamer interface [polypeptide binding]; other site
316056010599	Walker B motif; other site
316056010600	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
316056010601	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
316056010602	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
316056010603	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
316056010604	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056010605	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
316056010606	TPR motif; other site
316056010607	binding surface
316056010608	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056010609	binding surface
316056010610	TPR motif; other site
316056010611	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
316056010612	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
316056010613	interface (dimer of trimers) [polypeptide binding]; other site
316056010614	Substrate-binding/catalytic site; other site
316056010615	Zn-binding sites [ion binding]; other site
316056010616	Src Homology 3 domain superfamily; Region: SH3; cl17036
316056010617	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
316056010618	NlpC/P60 family; Region: NLPC_P60; cl17555
316056010619	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
316056010620	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
316056010621	dimer interface [polypeptide binding]; other site
316056010622	active site
316056010623	ADP-ribose binding site [chemical binding]; other site
316056010624	nudix motif; other site
316056010625	metal binding site [ion binding]; metal-binding site
316056010626	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
316056010627	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316056010628	Walker A/P-loop; other site
316056010629	ATP binding site [chemical binding]; other site
316056010630	Q-loop/lid; other site
316056010631	ABC transporter signature motif; other site
316056010632	Walker B; other site
316056010633	D-loop; other site
316056010634	H-loop/switch region; other site
316056010635	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316056010636	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
316056010637	Walker A/P-loop; other site
316056010638	ATP binding site [chemical binding]; other site
316056010639	Q-loop/lid; other site
316056010640	ABC transporter signature motif; other site
316056010641	Walker B; other site
316056010642	D-loop; other site
316056010643	H-loop/switch region; other site
316056010644	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
316056010645	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
316056010646	putative active site [active]
316056010647	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
316056010648	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056010649	dimer interface [polypeptide binding]; other site
316056010650	conserved gate region; other site
316056010651	putative PBP binding loops; other site
316056010652	ABC-ATPase subunit interface; other site
316056010653	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
316056010654	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056010655	dimer interface [polypeptide binding]; other site
316056010656	conserved gate region; other site
316056010657	putative PBP binding loops; other site
316056010658	ABC-ATPase subunit interface; other site
316056010659	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
316056010660	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
316056010661	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
316056010662	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
316056010663	Cytochrome c2 [Energy production and conversion]; Region: COG3474
316056010664	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
316056010665	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
316056010666	Ligand binding site; other site
316056010667	oligomer interface; other site
316056010668	prephenate dehydratase; Provisional; Region: PRK11899
316056010669	Prephenate dehydratase; Region: PDT; pfam00800
316056010670	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
316056010671	putative L-Phe binding site [chemical binding]; other site
316056010672	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
316056010673	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
316056010674	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
316056010675	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
316056010676	FAD binding site [chemical binding]; other site
316056010677	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
316056010678	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
316056010679	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
316056010680	substrate binding pocket [chemical binding]; other site
316056010681	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
316056010682	B12 binding site [chemical binding]; other site
316056010683	cobalt ligand [ion binding]; other site
316056010684	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
316056010685	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
316056010686	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056010687	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
316056010688	dimerization interface [polypeptide binding]; other site
316056010689	substrate binding pocket [chemical binding]; other site
316056010690	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
316056010691	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
316056010692	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
316056010693	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056010694	putative substrate translocation pore; other site
316056010695	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316056010696	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
316056010697	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
316056010698	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
316056010699	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
316056010700	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316056010701	catalytic residue [active]
316056010702	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
316056010703	cobyric acid synthase; Provisional; Region: PRK00784
316056010704	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
316056010705	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
316056010706	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
316056010707	catalytic triad [active]
316056010708	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
316056010709	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
316056010710	homodimer interface [polypeptide binding]; other site
316056010711	Walker A motif; other site
316056010712	ATP binding site [chemical binding]; other site
316056010713	hydroxycobalamin binding site [chemical binding]; other site
316056010714	Walker B motif; other site
316056010715	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
316056010716	homotrimer interface [polypeptide binding]; other site
316056010717	Walker A motif; other site
316056010718	GTP binding site [chemical binding]; other site
316056010719	Walker B motif; other site
316056010720	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
316056010721	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
316056010722	active site pocket [active]
316056010723	putative dimer interface [polypeptide binding]; other site
316056010724	putative cataytic base [active]
316056010725	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
316056010726	putative FMN binding site [chemical binding]; other site
316056010727	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
316056010728	IHF dimer interface [polypeptide binding]; other site
316056010729	IHF - DNA interface [nucleotide binding]; other site
316056010730	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
316056010731	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
316056010732	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
316056010733	putative active site pocket [active]
316056010734	dimerization interface [polypeptide binding]; other site
316056010735	putative catalytic residue [active]
316056010736	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
316056010737	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056010738	putative active site [active]
316056010739	heme pocket [chemical binding]; other site
316056010740	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056010741	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056010742	dimer interface [polypeptide binding]; other site
316056010743	phosphorylation site [posttranslational modification]
316056010744	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056010745	ATP binding site [chemical binding]; other site
316056010746	Mg2+ binding site [ion binding]; other site
316056010747	G-X-G motif; other site
316056010748	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
316056010749	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056010750	active site
316056010751	phosphorylation site [posttranslational modification]
316056010752	intermolecular recognition site; other site
316056010753	dimerization interface [polypeptide binding]; other site
316056010754	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056010755	Walker A motif; other site
316056010756	ATP binding site [chemical binding]; other site
316056010757	Walker B motif; other site
316056010758	arginine finger; other site
316056010759	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316056010760	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
316056010761	dimerization interface [polypeptide binding]; other site
316056010762	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
316056010763	ATP binding site [chemical binding]; other site
316056010764	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
316056010765	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
316056010766	HupF/HypC family; Region: HupF_HypC; pfam01455
316056010767	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
316056010768	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
316056010769	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
316056010770	hydrogenase 2 large subunit; Provisional; Region: PRK10467
316056010771	Protein of unknown function (DUF3457); Region: DUF3457; pfam11939
316056010772	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
316056010773	Rubredoxin; Region: Rubredoxin; pfam00301
316056010774	iron binding site [ion binding]; other site
316056010775	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
316056010776	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
316056010777	HupF/HypC family; Region: HupF_HypC; pfam01455
316056010778	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
316056010779	putative substrate-binding site; other site
316056010780	nickel binding site [ion binding]; other site
316056010781	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
316056010782	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
316056010783	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
316056010784	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
316056010785	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
316056010786	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
316056010787	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
316056010788	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
316056010789	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
316056010790	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
316056010791	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
316056010792	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
316056010793	GAF domain; Region: GAF; pfam01590
316056010794	Phytochrome region; Region: PHY; pfam00360
316056010795	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056010796	dimer interface [polypeptide binding]; other site
316056010797	phosphorylation site [posttranslational modification]
316056010798	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056010799	ATP binding site [chemical binding]; other site
316056010800	Mg2+ binding site [ion binding]; other site
316056010801	G-X-G motif; other site
316056010802	Response regulator receiver domain; Region: Response_reg; pfam00072
316056010803	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056010804	active site
316056010805	phosphorylation site [posttranslational modification]
316056010806	intermolecular recognition site; other site
316056010807	dimerization interface [polypeptide binding]; other site
316056010808	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
316056010809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056010810	active site
316056010811	phosphorylation site [posttranslational modification]
316056010812	intermolecular recognition site; other site
316056010813	dimerization interface [polypeptide binding]; other site
316056010814	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
316056010815	Histidine kinase; Region: HisKA_3; pfam07730
316056010816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056010817	ATP binding site [chemical binding]; other site
316056010818	Mg2+ binding site [ion binding]; other site
316056010819	G-X-G motif; other site
316056010820	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
316056010821	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
316056010822	PUCC protein; Region: PUCC; pfam03209
316056010823	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
316056010824	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
316056010825	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
316056010826	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056010827	active site
316056010828	phosphorylation site [posttranslational modification]
316056010829	intermolecular recognition site; other site
316056010830	dimerization interface [polypeptide binding]; other site
316056010831	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316056010832	DNA binding residues [nucleotide binding]
316056010833	dimerization interface [polypeptide binding]; other site
316056010834	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
316056010835	NAD(P) binding site [chemical binding]; other site
316056010836	catalytic residues [active]
316056010837	choline dehydrogenase; Validated; Region: PRK02106
316056010838	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
316056010839	short chain dehydrogenase; Provisional; Region: PRK06949
316056010840	classical (c) SDRs; Region: SDR_c; cd05233
316056010841	NAD(P) binding site [chemical binding]; other site
316056010842	active site
316056010843	Colicin V production protein; Region: Colicin_V; pfam02674
316056010844	short chain dehydrogenase; Provisional; Region: PRK08339
316056010845	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
316056010846	putative NAD(P) binding site [chemical binding]; other site
316056010847	putative active site [active]
316056010848	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
316056010849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056010850	active site
316056010851	phosphorylation site [posttranslational modification]
316056010852	intermolecular recognition site; other site
316056010853	dimerization interface [polypeptide binding]; other site
316056010854	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316056010855	DNA binding residues [nucleotide binding]
316056010856	dimerization interface [polypeptide binding]; other site
316056010857	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
316056010858	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056010859	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056010860	dimer interface [polypeptide binding]; other site
316056010861	phosphorylation site [posttranslational modification]
316056010862	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056010863	ATP binding site [chemical binding]; other site
316056010864	Mg2+ binding site [ion binding]; other site
316056010865	G-X-G motif; other site
316056010866	Response regulator receiver domain; Region: Response_reg; pfam00072
316056010867	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056010868	active site
316056010869	phosphorylation site [posttranslational modification]
316056010870	intermolecular recognition site; other site
316056010871	dimerization interface [polypeptide binding]; other site
316056010872	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
316056010873	putative binding surface; other site
316056010874	active site
316056010875	Response regulator receiver domain; Region: Response_reg; pfam00072
316056010876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056010877	active site
316056010878	phosphorylation site [posttranslational modification]
316056010879	intermolecular recognition site; other site
316056010880	dimerization interface [polypeptide binding]; other site
316056010881	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056010882	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
316056010883	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
316056010884	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
316056010885	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
316056010886	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
316056010887	putative binding surface; other site
316056010888	active site
316056010889	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
316056010890	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
316056010891	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056010892	ATP binding site [chemical binding]; other site
316056010893	Mg2+ binding site [ion binding]; other site
316056010894	G-X-G motif; other site
316056010895	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
316056010896	Response regulator receiver domain; Region: Response_reg; pfam00072
316056010897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056010898	active site
316056010899	phosphorylation site [posttranslational modification]
316056010900	intermolecular recognition site; other site
316056010901	dimerization interface [polypeptide binding]; other site
316056010902	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
316056010903	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056010904	dimerization interface [polypeptide binding]; other site
316056010905	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056010906	dimer interface [polypeptide binding]; other site
316056010907	putative CheW interface [polypeptide binding]; other site
316056010908	Response regulator receiver domain; Region: Response_reg; pfam00072
316056010909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056010910	phosphorylation site [posttranslational modification]
316056010911	intermolecular recognition site; other site
316056010912	Acetokinase family; Region: Acetate_kinase; cl17229
316056010913	propionate/acetate kinase; Provisional; Region: PRK12379
316056010914	putative phosphoketolase; Provisional; Region: PRK05261
316056010915	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
316056010916	TPP-binding site; other site
316056010917	XFP C-terminal domain; Region: XFP_C; pfam09363
316056010918	BON domain; Region: BON; pfam04972
316056010919	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
316056010920	BON domain; Region: BON; pfam04972
316056010921	BON domain; Region: BON; pfam04972
316056010922	Protein kinase domain; Region: Pkinase; pfam00069
316056010923	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
316056010924	active site
316056010925	ATP binding site [chemical binding]; other site
316056010926	substrate binding site [chemical binding]; other site
316056010927	activation loop (A-loop); other site
316056010928	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316056010929	Ligand Binding Site [chemical binding]; other site
316056010930	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
316056010931	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
316056010932	active site
316056010933	metal binding site [ion binding]; metal-binding site
316056010934	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
316056010935	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
316056010936	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056010937	FeS/SAM binding site; other site
316056010938	V4R domain; Region: V4R; cl15268
316056010939	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
316056010940	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056010941	FeS/SAM binding site; other site
316056010942	HemN C-terminal domain; Region: HemN_C; pfam06969
316056010943	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
316056010944	putative homodimer interface [polypeptide binding]; other site
316056010945	putative homotetramer interface [polypeptide binding]; other site
316056010946	putative allosteric switch controlling residues; other site
316056010947	putative metal binding site [ion binding]; other site
316056010948	putative homodimer-homodimer interface [polypeptide binding]; other site
316056010949	YHS domain; Region: YHS; pfam04945
316056010950	YHS domain; Region: YHS; pfam04945
316056010951	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
316056010952	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
316056010953	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316056010954	motif II; other site
316056010955	Hemerythrin-like domain; Region: Hr-like; cd12108
316056010956	Fe binding site [ion binding]; other site
316056010957	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
316056010958	active site
316056010959	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056010960	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056010961	metal binding site [ion binding]; metal-binding site
316056010962	active site
316056010963	I-site; other site
316056010964	Domain of unknown function (DUF336); Region: DUF336; cl01249
316056010965	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316056010966	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316056010967	active site
316056010968	catalytic tetrad [active]
316056010969	eRF1 domain 2; Region: eRF1_2; pfam03464
316056010970	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
316056010971	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
316056010972	Walker A/P-loop; other site
316056010973	ATP binding site [chemical binding]; other site
316056010974	Q-loop/lid; other site
316056010975	ABC transporter signature motif; other site
316056010976	Walker B; other site
316056010977	D-loop; other site
316056010978	H-loop/switch region; other site
316056010979	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
316056010980	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
316056010981	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056010982	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056010983	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
316056010984	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
316056010985	catalytic site [active]
316056010986	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
316056010987	methionine sulfoxide reductase B; Provisional; Region: PRK00222
316056010988	SelR domain; Region: SelR; pfam01641
316056010989	methionine sulfoxide reductase A; Provisional; Region: PRK13014
316056010990	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
316056010991	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
316056010992	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
316056010993	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
316056010994	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
316056010995	ATP-grasp domain; Region: ATP-grasp_4; cl17255
316056010996	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
316056010997	IMP binding site; other site
316056010998	dimer interface [polypeptide binding]; other site
316056010999	interdomain contacts; other site
316056011000	partial ornithine binding site; other site
316056011001	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
316056011002	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
316056011003	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
316056011004	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
316056011005	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
316056011006	putative DNA binding site [nucleotide binding]; other site
316056011007	putative Zn2+ binding site [ion binding]; other site
316056011008	AsnC family; Region: AsnC_trans_reg; pfam01037
316056011009	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
316056011010	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
316056011011	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316056011012	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056011013	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056011014	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
316056011015	putative effector binding pocket; other site
316056011016	dimerization interface [polypeptide binding]; other site
316056011017	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
316056011018	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
316056011019	P-loop; other site
316056011020	Magnesium ion binding site [ion binding]; other site
316056011021	IPP transferase; Region: IPPT; pfam01715
316056011022	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
316056011023	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
316056011024	Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990
316056011025	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
316056011026	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
316056011027	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
316056011028	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
316056011029	D-pathway; other site
316056011030	Putative ubiquinol binding site [chemical binding]; other site
316056011031	Low-spin heme (heme b) binding site [chemical binding]; other site
316056011032	Putative water exit pathway; other site
316056011033	Binuclear center (heme o3/CuB) [ion binding]; other site
316056011034	K-pathway; other site
316056011035	Putative proton exit pathway; other site
316056011036	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
316056011037	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
316056011038	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
316056011039	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
316056011040	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056011041	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056011042	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
316056011043	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
316056011044	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056011045	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
316056011046	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
316056011047	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
316056011048	universal stress protein UspE; Provisional; Region: PRK11175
316056011049	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316056011050	Ligand Binding Site [chemical binding]; other site
316056011051	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316056011052	Ligand Binding Site [chemical binding]; other site
316056011053	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
316056011054	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
316056011055	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
316056011056	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
316056011057	Soluble P-type ATPase [General function prediction only]; Region: COG4087
316056011058	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
316056011059	Cache domain; Region: Cache_1; pfam02743
316056011060	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
316056011061	Histidine kinase; Region: HisKA_2; pfam07568
316056011062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056011063	ATP binding site [chemical binding]; other site
316056011064	Mg2+ binding site [ion binding]; other site
316056011065	G-X-G motif; other site
316056011066	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
316056011067	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056011068	dimer interface [polypeptide binding]; other site
316056011069	conserved gate region; other site
316056011070	ABC-ATPase subunit interface; other site
316056011071	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
316056011072	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056011073	dimer interface [polypeptide binding]; other site
316056011074	conserved gate region; other site
316056011075	ABC-ATPase subunit interface; other site
316056011076	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
316056011077	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
316056011078	Walker A/P-loop; other site
316056011079	ATP binding site [chemical binding]; other site
316056011080	Q-loop/lid; other site
316056011081	ABC transporter signature motif; other site
316056011082	Walker B; other site
316056011083	D-loop; other site
316056011084	H-loop/switch region; other site
316056011085	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
316056011086	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
316056011087	active site
316056011088	DNA binding site [nucleotide binding]
316056011089	Int/Topo IB signature motif; other site
316056011090	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
316056011091	putative metal binding site [ion binding]; other site
316056011092	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
316056011093	putative catalytic site [active]
316056011094	putative phosphate binding site [ion binding]; other site
316056011095	putative metal binding site [ion binding]; other site
316056011096	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
316056011097	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
316056011098	tetramer interface [polypeptide binding]; other site
316056011099	active site
316056011100	Mg2+/Mn2+ binding site [ion binding]; other site
316056011101	2-aminoethylphosphonate aminotransferase; Region: PhnW-AepZ; TIGR03301
316056011102	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316056011103	catalytic residue [active]
316056011104	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
316056011105	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
316056011106	active site
316056011107	metal-binding site
316056011108	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
316056011109	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
316056011110	active site
316056011111	dimer interface [polypeptide binding]; other site
316056011112	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
316056011113	Ligand Binding Site [chemical binding]; other site
316056011114	Molecular Tunnel; other site
316056011115	HprK-related kinase B; Region: HprK_rel_B; TIGR04355
316056011116	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
316056011117	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
316056011118	active site
316056011119	metal binding site [ion binding]; metal-binding site
316056011120	hexamer interface [polypeptide binding]; other site
316056011121	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
316056011122	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
316056011123	PYR/PP interface [polypeptide binding]; other site
316056011124	dimer interface [polypeptide binding]; other site
316056011125	TPP binding site [chemical binding]; other site
316056011126	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
316056011127	transketolase; Reviewed; Region: PRK05899
316056011128	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
316056011129	TPP-binding site [chemical binding]; other site
316056011130	dimer interface [polypeptide binding]; other site
316056011131	Cupin domain; Region: Cupin_2; cl17218
316056011132	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
316056011133	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
316056011134	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
316056011135	HTH-like domain; Region: HTH_21; pfam13276
316056011136	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
316056011137	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
316056011138	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
316056011139	VirB7 interaction site; other site
316056011140	conjugal transfer protein TrbF; Provisional; Region: PRK13872
316056011141	conjugal transfer protein TrbL; Provisional; Region: PRK13875
316056011142	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
316056011143	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
316056011144	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
316056011145	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314
316056011146	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
316056011147	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
316056011148	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056011149	Walker A/P-loop; other site
316056011150	ATP binding site [chemical binding]; other site
316056011151	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
316056011152	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
316056011153	TrbC/VIRB2 family; Region: TrbC; pfam04956
316056011154	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
316056011155	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
316056011156	Walker A motif; other site
316056011157	ATP binding site [chemical binding]; other site
316056011158	Walker B motif; other site
316056011159	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
316056011160	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
316056011161	Walker A motif; other site
316056011162	ATP binding site [chemical binding]; other site
316056011163	Walker B motif; other site
316056011164	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
316056011165	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
316056011166	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
316056011167	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
316056011168	N-acetyl-D-glucosamine binding site [chemical binding]; other site
316056011169	catalytic residue [active]
316056011170	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
316056011171	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
316056011172	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
316056011173	Replication initiator protein A; Region: RPA; pfam10134
316056011174	Helix-turn-helix domain; Region: HTH_17; pfam12728
316056011175	Transposase, Mutator family; Region: Transposase_mut; pfam00872
316056011176	MULE transposase domain; Region: MULE; pfam10551
316056011177	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
316056011178	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
316056011179	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056011180	non-specific DNA binding site [nucleotide binding]; other site
316056011181	salt bridge; other site
316056011182	sequence-specific DNA binding site [nucleotide binding]; other site
316056011183	Uncharacterized conserved protein [Function unknown]; Region: COG5489
316056011184	OPT oligopeptide transporter protein; Region: OPT; cl14607
316056011185	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
316056011186	Toprim domain; Region: Toprim_3; pfam13362
316056011187	Methyltransferase domain; Region: Methyltransf_26; pfam13659
316056011188	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
316056011189	Helicase_C-like; Region: Helicase_C_4; pfam13871
316056011190	ParB-like nuclease domain; Region: ParBc; pfam02195
316056011191	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
316056011192	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
316056011193	RES domain; Region: RES; smart00953
316056011194	AAA domain; Region: AAA_11; pfam13086
316056011195	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
316056011196	AAA domain; Region: AAA_12; pfam13087
316056011197	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133
316056011198	PLD-like domain; Region: PLDc_2; pfam13091
316056011199	putative active site [active]
316056011200	putative catalytic site [active]
316056011201	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
316056011202	PLD-like domain; Region: PLDc_2; pfam13091
316056011203	putative active site [active]
316056011204	catalytic site [active]
316056011205	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056011206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056011207	ATP binding site [chemical binding]; other site
316056011208	Mg2+ binding site [ion binding]; other site
316056011209	G-X-G motif; other site
316056011210	GAF domain; Region: GAF; pfam01590
316056011211	GAF domain; Region: GAF_2; pfam13185
316056011212	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056011213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056011214	ATP binding site [chemical binding]; other site
316056011215	Mg2+ binding site [ion binding]; other site
316056011216	G-X-G motif; other site
316056011217	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
316056011218	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
316056011219	putative homodimer interface [polypeptide binding]; other site
316056011220	PLD-like domain; Region: PLDc_2; pfam13091
316056011221	putative active site [active]
316056011222	catalytic site [active]
316056011223	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316056011224	ATP-binding site [chemical binding]; other site
316056011225	Nuclease-related domain; Region: NERD; pfam08378
316056011226	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
316056011227	active site
316056011228	ATP binding site [chemical binding]; other site
316056011229	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
316056011230	substrate binding site [chemical binding]; other site
316056011231	activation loop (A-loop); other site
316056011232	AAA domain; Region: AAA_12; pfam13087
316056011233	Transposase, Mutator family; Region: Transposase_mut; pfam00872
316056011234	MULE transposase domain; Region: MULE; pfam10551
316056011235	phasin; Region: phasin_2; TIGR01985
316056011236	Phasin protein; Region: Phasin_2; cl11491
316056011237	PAS domain; Region: PAS_9; pfam13426
316056011238	PAS domain S-box; Region: sensory_box; TIGR00229
316056011239	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056011240	putative active site [active]
316056011241	heme pocket [chemical binding]; other site
316056011242	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056011243	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056011244	dimer interface [polypeptide binding]; other site
316056011245	phosphorylation site [posttranslational modification]
316056011246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056011247	ATP binding site [chemical binding]; other site
316056011248	Mg2+ binding site [ion binding]; other site
316056011249	G-X-G motif; other site
316056011250	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
316056011251	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
316056011252	putative active site [active]
316056011253	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056011254	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056011255	ligand binding site [chemical binding]; other site
316056011256	flexible hinge region; other site
316056011257	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
316056011258	putative switch regulator; other site
316056011259	non-specific DNA interactions [nucleotide binding]; other site
316056011260	DNA binding site [nucleotide binding]
316056011261	sequence specific DNA binding site [nucleotide binding]; other site
316056011262	putative cAMP binding site [chemical binding]; other site
316056011263	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
316056011264	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
316056011265	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
316056011266	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
316056011267	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056011268	ABC-ATPase subunit interface; other site
316056011269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056011270	ABC-ATPase subunit interface; other site
316056011271	putative PBP binding loops; other site
316056011272	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
316056011273	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
316056011274	AsmA family; Region: AsmA; pfam05170
316056011275	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
316056011276	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
316056011277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056011278	dimer interface [polypeptide binding]; other site
316056011279	conserved gate region; other site
316056011280	putative PBP binding loops; other site
316056011281	ABC-ATPase subunit interface; other site
316056011282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056011283	dimer interface [polypeptide binding]; other site
316056011284	conserved gate region; other site
316056011285	putative PBP binding loops; other site
316056011286	ABC-ATPase subunit interface; other site
316056011287	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
316056011288	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056011289	Walker A/P-loop; other site
316056011290	ATP binding site [chemical binding]; other site
316056011291	Q-loop/lid; other site
316056011292	ABC transporter signature motif; other site
316056011293	Walker B; other site
316056011294	D-loop; other site
316056011295	H-loop/switch region; other site
316056011296	TOBE domain; Region: TOBE_2; pfam08402
316056011297	PAS domain; Region: PAS; smart00091
316056011298	PAS fold; Region: PAS_7; pfam12860
316056011299	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
316056011300	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056011301	putative active site [active]
316056011302	heme pocket [chemical binding]; other site
316056011303	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056011304	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056011305	metal binding site [ion binding]; metal-binding site
316056011306	active site
316056011307	I-site; other site
316056011308	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056011309	Predicted dehydrogenase [General function prediction only]; Region: COG0579
316056011310	hydroxyglutarate oxidase; Provisional; Region: PRK11728
316056011311	Uncharacterized small protein [Function unknown]; Region: COG5570
316056011312	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
316056011313	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056011314	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056011315	metal binding site [ion binding]; metal-binding site
316056011316	active site
316056011317	I-site; other site
316056011318	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
316056011319	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
316056011320	ATP-grasp domain; Region: ATP-grasp; pfam02222
316056011321	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
316056011322	Cupin domain; Region: Cupin_2; cl17218
316056011323	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
316056011324	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
316056011325	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
316056011326	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
316056011327	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
316056011328	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
316056011329	ligand binding site [chemical binding]; other site
316056011330	homodimer interface [polypeptide binding]; other site
316056011331	NAD(P) binding site [chemical binding]; other site
316056011332	trimer interface B [polypeptide binding]; other site
316056011333	trimer interface A [polypeptide binding]; other site
316056011334	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
316056011335	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
316056011336	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
316056011337	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
316056011338	active site
316056011339	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
316056011340	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
316056011341	active site
316056011342	Zn binding site [ion binding]; other site
316056011343	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
316056011344	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
316056011345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056011346	active site
316056011347	phosphorylation site [posttranslational modification]
316056011348	intermolecular recognition site; other site
316056011349	dimerization interface [polypeptide binding]; other site
316056011350	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056011351	Walker A motif; other site
316056011352	ATP binding site [chemical binding]; other site
316056011353	Walker B motif; other site
316056011354	arginine finger; other site
316056011355	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316056011356	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
316056011357	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
316056011358	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316056011359	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316056011360	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
316056011361	Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951
316056011362	hypothetical protein; Provisional; Region: PRK13694
316056011363	Protein of unknown function (DUF1036); Region: DUF1036; pfam06282
316056011364	pyruvate kinase; Provisional; Region: PRK06247
316056011365	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
316056011366	domain interfaces; other site
316056011367	active site
316056011368	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
316056011369	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
316056011370	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
316056011371	putative NAD(P) binding site [chemical binding]; other site
316056011372	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056011373	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
316056011374	sequence-specific DNA binding site [nucleotide binding]; other site
316056011375	salt bridge; other site
316056011376	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
316056011377	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
316056011378	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056011379	binding surface
316056011380	TPR repeat; Region: TPR_11; pfam13414
316056011381	TPR motif; other site
316056011382	TPR repeat; Region: TPR_11; pfam13414
316056011383	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
316056011384	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
316056011385	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
316056011386	active site
316056011387	catalytic site [active]
316056011388	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
316056011389	active site
316056011390	catalytic site [active]
316056011391	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
316056011392	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
316056011393	Bacterial transcriptional regulator; Region: IclR; pfam01614
316056011394	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
316056011395	putative deacylase active site [active]
316056011396	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
316056011397	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
316056011398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056011399	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
316056011400	NAD(P) binding site [chemical binding]; other site
316056011401	active site
316056011402	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
316056011403	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
316056011404	active site
316056011405	nucleophile elbow; other site
316056011406	Patatin phospholipase; Region: DUF3734; pfam12536
316056011407	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
316056011408	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
316056011409	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
316056011410	Walker A/P-loop; other site
316056011411	ATP binding site [chemical binding]; other site
316056011412	Q-loop/lid; other site
316056011413	ABC transporter signature motif; other site
316056011414	Walker B; other site
316056011415	D-loop; other site
316056011416	H-loop/switch region; other site
316056011417	TOBE-like domain; Region: TOBE_3; pfam12857
316056011418	sulfate transport protein; Provisional; Region: cysT; CHL00187
316056011419	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056011420	dimer interface [polypeptide binding]; other site
316056011421	conserved gate region; other site
316056011422	putative PBP binding loops; other site
316056011423	ABC-ATPase subunit interface; other site
316056011424	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
316056011425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056011426	dimer interface [polypeptide binding]; other site
316056011427	conserved gate region; other site
316056011428	putative PBP binding loops; other site
316056011429	ABC-ATPase subunit interface; other site
316056011430	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316056011431	substrate binding pocket [chemical binding]; other site
316056011432	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
316056011433	membrane-bound complex binding site; other site
316056011434	hinge residues; other site
316056011435	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
316056011436	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
316056011437	Active Sites [active]
316056011438	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
316056011439	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
316056011440	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
316056011441	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
316056011442	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
316056011443	siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470
316056011444	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
316056011445	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
316056011446	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
316056011447	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
316056011448	active site
316056011449	SAM binding site [chemical binding]; other site
316056011450	homodimer interface [polypeptide binding]; other site
316056011451	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
316056011452	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
316056011453	Active Sites [active]
316056011454	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
316056011455	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
316056011456	CysD dimerization site [polypeptide binding]; other site
316056011457	G1 box; other site
316056011458	putative GEF interaction site [polypeptide binding]; other site
316056011459	GTP/Mg2+ binding site [chemical binding]; other site
316056011460	Switch I region; other site
316056011461	G2 box; other site
316056011462	G3 box; other site
316056011463	Switch II region; other site
316056011464	G4 box; other site
316056011465	G5 box; other site
316056011466	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
316056011467	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
316056011468	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
316056011469	ligand-binding site [chemical binding]; other site
316056011470	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
316056011471	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
316056011472	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
316056011473	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056011474	dimer interface [polypeptide binding]; other site
316056011475	conserved gate region; other site
316056011476	putative PBP binding loops; other site
316056011477	ABC-ATPase subunit interface; other site
316056011478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056011479	dimer interface [polypeptide binding]; other site
316056011480	conserved gate region; other site
316056011481	putative PBP binding loops; other site
316056011482	ABC-ATPase subunit interface; other site
316056011483	malate synthase G; Provisional; Region: PRK02999
316056011484	active site
316056011485	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
316056011486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
316056011487	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316056011488	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
316056011489	Domain of unknown function DUF20; Region: UPF0118; pfam01594
316056011490	two-component response regulator; Provisional; Region: PRK09191
316056011491	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056011492	active site
316056011493	phosphorylation site [posttranslational modification]
316056011494	intermolecular recognition site; other site
316056011495	dimerization interface [polypeptide binding]; other site
316056011496	RNA polymerase sigma factor; Provisional; Region: PRK12540
316056011497	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316056011498	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316056011499	DNA binding residues [nucleotide binding]
316056011500	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
316056011501	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
316056011502	HWE histidine kinase; Region: HWE_HK; pfam07536
316056011503	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
316056011504	G1 box; other site
316056011505	GTP/Mg2+ binding site [chemical binding]; other site
316056011506	G2 box; other site
316056011507	Switch I region; other site
316056011508	G3 box; other site
316056011509	Switch II region; other site
316056011510	G4 box; other site
316056011511	G5 box; other site
316056011512	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
316056011513	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
316056011514	putative [4Fe-4S] binding site [ion binding]; other site
316056011515	putative molybdopterin cofactor binding site [chemical binding]; other site
316056011516	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
316056011517	putative molybdopterin cofactor binding site; other site
316056011518	Ion transport protein; Region: Ion_trans; pfam00520
316056011519	Ion channel; Region: Ion_trans_2; pfam07885
316056011520	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056011521	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056011522	ligand binding site [chemical binding]; other site
316056011523	flexible hinge region; other site
316056011524	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056011525	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056011526	ligand binding site [chemical binding]; other site
316056011527	flexible hinge region; other site
316056011528	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
316056011529	putative switch regulator; other site
316056011530	non-specific DNA interactions [nucleotide binding]; other site
316056011531	DNA binding site [nucleotide binding]
316056011532	sequence specific DNA binding site [nucleotide binding]; other site
316056011533	putative cAMP binding site [chemical binding]; other site
316056011534	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
316056011535	Cytochrome c; Region: Cytochrom_C; pfam00034
316056011536	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
316056011537	mce related protein; Region: MCE; pfam02470
316056011538	Protein of unknown function (DUF330); Region: DUF330; cl01135
316056011539	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
316056011540	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
316056011541	Walker A/P-loop; other site
316056011542	ATP binding site [chemical binding]; other site
316056011543	Q-loop/lid; other site
316056011544	ABC transporter signature motif; other site
316056011545	Walker B; other site
316056011546	D-loop; other site
316056011547	H-loop/switch region; other site
316056011548	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
316056011549	anti sigma factor interaction site; other site
316056011550	regulatory phosphorylation site [posttranslational modification]; other site
316056011551	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
316056011552	Permease; Region: Permease; pfam02405
316056011553	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
316056011554	CoA binding domain; Region: CoA_binding_2; pfam13380
316056011555	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
316056011556	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
316056011557	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
316056011558	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
316056011559	FOG: CBS domain [General function prediction only]; Region: COG0517
316056011560	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
316056011561	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
316056011562	substrate binding site [chemical binding]; other site
316056011563	Predicted kinase [General function prediction only]; Region: COG0645
316056011564	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
316056011565	active site
316056011566	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
316056011567	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
316056011568	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
316056011569	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316056011570	Ligand Binding Site [chemical binding]; other site
316056011571	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
316056011572	Ligand Binding Site [chemical binding]; other site
316056011573	FOG: CBS domain [General function prediction only]; Region: COG0517
316056011574	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
316056011575	BON domain; Region: BON; pfam04972
316056011576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056011577	PAS fold; Region: PAS_3; pfam08447
316056011578	putative active site [active]
316056011579	heme pocket [chemical binding]; other site
316056011580	PAS domain S-box; Region: sensory_box; TIGR00229
316056011581	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056011582	putative active site [active]
316056011583	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056011584	dimer interface [polypeptide binding]; other site
316056011585	phosphorylation site [posttranslational modification]
316056011586	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056011587	ATP binding site [chemical binding]; other site
316056011588	Mg2+ binding site [ion binding]; other site
316056011589	G-X-G motif; other site
316056011590	response regulator FixJ; Provisional; Region: fixJ; PRK09390
316056011591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056011592	active site
316056011593	phosphorylation site [posttranslational modification]
316056011594	intermolecular recognition site; other site
316056011595	dimerization interface [polypeptide binding]; other site
316056011596	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316056011597	DNA binding residues [nucleotide binding]
316056011598	dimerization interface [polypeptide binding]; other site
316056011599	Response regulator receiver domain; Region: Response_reg; pfam00072
316056011600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056011601	active site
316056011602	phosphorylation site [posttranslational modification]
316056011603	intermolecular recognition site; other site
316056011604	dimerization interface [polypeptide binding]; other site
316056011605	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
316056011606	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056011607	ligand binding site [chemical binding]; other site
316056011608	flexible hinge region; other site
316056011609	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
316056011610	putative switch regulator; other site
316056011611	non-specific DNA interactions [nucleotide binding]; other site
316056011612	DNA binding site [nucleotide binding]
316056011613	sequence specific DNA binding site [nucleotide binding]; other site
316056011614	putative cAMP binding site [chemical binding]; other site
316056011615	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
316056011616	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
316056011617	homodimer interface [polypeptide binding]; other site
316056011618	substrate-cofactor binding pocket; other site
316056011619	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056011620	catalytic residue [active]
316056011621	DDE superfamily endonuclease; Region: DDE_3; pfam13358
316056011622	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
316056011623	Homeodomain-like domain; Region: HTH_23; pfam13384
316056011624	Winged helix-turn helix; Region: HTH_29; pfam13551
316056011625	Winged helix-turn helix; Region: HTH_33; pfam13592
316056011626	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056011627	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
316056011628	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056011629	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056011630	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
316056011631	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
316056011632	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
316056011633	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
316056011634	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
316056011635	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
316056011636	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316056011637	NADH dehydrogenase subunit G; Validated; Region: PRK08166
316056011638	catalytic loop [active]
316056011639	iron binding site [ion binding]; other site
316056011640	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
316056011641	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
316056011642	[4Fe-4S] binding site [ion binding]; other site
316056011643	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
316056011644	SLBB domain; Region: SLBB; pfam10531
316056011645	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
316056011646	NADH dehydrogenase subunit E; Validated; Region: PRK07539
316056011647	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
316056011648	putative dimer interface [polypeptide binding]; other site
316056011649	[2Fe-2S] cluster binding site [ion binding]; other site
316056011650	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
316056011651	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
316056011652	NADH dehydrogenase subunit D; Validated; Region: PRK06075
316056011653	NADH dehydrogenase subunit B; Validated; Region: PRK06411
316056011654	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
316056011655	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
316056011656	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316056011657	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
316056011658	Walker A/P-loop; other site
316056011659	ATP binding site [chemical binding]; other site
316056011660	Q-loop/lid; other site
316056011661	ABC transporter signature motif; other site
316056011662	Walker B; other site
316056011663	D-loop; other site
316056011664	H-loop/switch region; other site
316056011665	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
316056011666	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
316056011667	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
316056011668	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
316056011669	acyl-activating enzyme (AAE) consensus motif; other site
316056011670	putative AMP binding site [chemical binding]; other site
316056011671	putative active site [active]
316056011672	putative CoA binding site [chemical binding]; other site
316056011673	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
316056011674	catalytic triad [active]
316056011675	dimer interface [polypeptide binding]; other site
316056011676	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
316056011677	RNA/DNA hybrid binding site [nucleotide binding]; other site
316056011678	active site
316056011679	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
316056011680	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
316056011681	putative active site [active]
316056011682	putative substrate binding site [chemical binding]; other site
316056011683	ATP binding site [chemical binding]; other site
316056011684	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
316056011685	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
316056011686	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
316056011687	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
316056011688	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
316056011689	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
316056011690	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
316056011691	GDP-binding site [chemical binding]; other site
316056011692	ACT binding site; other site
316056011693	IMP binding site; other site
316056011694	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316056011695	DNA binding residues [nucleotide binding]
316056011696	dimerization interface [polypeptide binding]; other site
316056011697	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
316056011698	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
316056011699	Beta-Casp domain; Region: Beta-Casp; smart01027
316056011700	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
316056011701	thymidine phosphorylase; Provisional; Region: PRK04350
316056011702	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
316056011703	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
316056011704	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
316056011705	Transcriptional regulators [Transcription]; Region: MarR; COG1846
316056011706	MarR family; Region: MarR; pfam01047
316056011707	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
316056011708	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
316056011709	putative NAD(P) binding site [chemical binding]; other site
316056011710	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
316056011711	putative deacylase active site [active]
316056011712	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
316056011713	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056011714	Coenzyme A binding pocket [chemical binding]; other site
316056011715	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
316056011716	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
316056011717	EamA-like transporter family; Region: EamA; pfam00892
316056011718	EamA-like transporter family; Region: EamA; pfam00892
316056011719	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
316056011720	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316056011721	N-terminal plug; other site
316056011722	ligand-binding site [chemical binding]; other site
316056011723	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056011724	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
316056011725	putative active site [active]
316056011726	heme pocket [chemical binding]; other site
316056011727	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
316056011728	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056011729	putative active site [active]
316056011730	heme pocket [chemical binding]; other site
316056011731	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056011732	putative active site [active]
316056011733	heme pocket [chemical binding]; other site
316056011734	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056011735	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056011736	dimer interface [polypeptide binding]; other site
316056011737	putative CheW interface [polypeptide binding]; other site
316056011738	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056011739	PAS domain; Region: PAS_9; pfam13426
316056011740	putative active site [active]
316056011741	heme pocket [chemical binding]; other site
316056011742	PAS domain; Region: PAS_9; pfam13426
316056011743	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056011744	putative active site [active]
316056011745	heme pocket [chemical binding]; other site
316056011746	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056011747	PAS fold; Region: PAS_3; pfam08447
316056011748	putative active site [active]
316056011749	heme pocket [chemical binding]; other site
316056011750	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056011751	dimer interface [polypeptide binding]; other site
316056011752	putative CheW interface [polypeptide binding]; other site
316056011753	Nitrate and nitrite sensing; Region: NIT; pfam08376
316056011754	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056011755	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056011756	dimer interface [polypeptide binding]; other site
316056011757	putative CheW interface [polypeptide binding]; other site
316056011758	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
316056011759	diiron binding motif [ion binding]; other site
316056011760	Uncharacterized conserved protein [Function unknown]; Region: COG1633
316056011761	CCC1-related family of proteins; Region: CCC1_like; cl00278
316056011762	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
316056011763	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
316056011764	HAMP domain; Region: HAMP; pfam00672
316056011765	dimerization interface [polypeptide binding]; other site
316056011766	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
316056011767	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056011768	dimer interface [polypeptide binding]; other site
316056011769	putative CheW interface [polypeptide binding]; other site
316056011770	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
316056011771	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056011772	dimerization interface [polypeptide binding]; other site
316056011773	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056011774	dimer interface [polypeptide binding]; other site
316056011775	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
316056011776	putative CheW interface [polypeptide binding]; other site
316056011777	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
316056011778	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
316056011779	ligand binding site [chemical binding]; other site
316056011780	NAD binding site [chemical binding]; other site
316056011781	dimerization interface [polypeptide binding]; other site
316056011782	catalytic site [active]
316056011783	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
316056011784	putative L-serine binding site [chemical binding]; other site
316056011785	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
316056011786	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316056011787	catalytic residue [active]
316056011788	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
316056011789	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056011790	Coenzyme A binding pocket [chemical binding]; other site
316056011791	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
316056011792	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
316056011793	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056011794	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316056011795	putative substrate translocation pore; other site
316056011796	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
316056011797	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
316056011798	active site
316056011799	substrate binding site [chemical binding]; other site
316056011800	metal binding site [ion binding]; metal-binding site
316056011801	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
316056011802	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
316056011803	phosphate binding site [ion binding]; other site
316056011804	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
316056011805	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
316056011806	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
316056011807	shikimate binding site; other site
316056011808	NAD(P) binding site [chemical binding]; other site
316056011809	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056011810	non-specific DNA binding site [nucleotide binding]; other site
316056011811	salt bridge; other site
316056011812	sequence-specific DNA binding site [nucleotide binding]; other site
316056011813	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
316056011814	elongation factor G; Reviewed; Region: PRK12740
316056011815	G1 box; other site
316056011816	putative GEF interaction site [polypeptide binding]; other site
316056011817	GTP/Mg2+ binding site [chemical binding]; other site
316056011818	Switch I region; other site
316056011819	G2 box; other site
316056011820	G3 box; other site
316056011821	Switch II region; other site
316056011822	G4 box; other site
316056011823	G5 box; other site
316056011824	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
316056011825	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
316056011826	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
316056011827	Protein of unknown function (DUF992); Region: DUF992; pfam06186
316056011828	Protein of unknown function (DUF992); Region: DUF992; pfam06186
316056011829	aspartate aminotransferase; Provisional; Region: PRK05764
316056011830	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316056011831	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056011832	homodimer interface [polypeptide binding]; other site
316056011833	catalytic residue [active]
316056011834	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
316056011835	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
316056011836	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
316056011837	putative C-terminal domain interface [polypeptide binding]; other site
316056011838	putative GSH binding site (G-site) [chemical binding]; other site
316056011839	putative dimer interface [polypeptide binding]; other site
316056011840	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
316056011841	N-terminal domain interface [polypeptide binding]; other site
316056011842	dimer interface [polypeptide binding]; other site
316056011843	substrate binding pocket (H-site) [chemical binding]; other site
316056011844	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
316056011845	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
316056011846	Protein of unknown function, DUF486; Region: DUF486; cl01236
316056011847	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
316056011848	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
316056011849	putative acyl-acceptor binding pocket; other site
316056011850	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316056011851	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316056011852	active site
316056011853	catalytic tetrad [active]
316056011854	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
316056011855	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
316056011856	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
316056011857	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
316056011858	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
316056011859	motif II; other site
316056011860	GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038
316056011861	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
316056011862	putative C-terminal domain interface [polypeptide binding]; other site
316056011863	putative GSH binding site (G-site) [chemical binding]; other site
316056011864	putative dimer interface [polypeptide binding]; other site
316056011865	C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202
316056011866	putative N-terminal domain interface [polypeptide binding]; other site
316056011867	putative dimer interface [polypeptide binding]; other site
316056011868	putative substrate binding pocket (H-site) [chemical binding]; other site
316056011869	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
316056011870	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
316056011871	C-terminal domain interface [polypeptide binding]; other site
316056011872	GSH binding site (G-site) [chemical binding]; other site
316056011873	dimer interface [polypeptide binding]; other site
316056011874	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
316056011875	N-terminal domain interface [polypeptide binding]; other site
316056011876	putative dimer interface [polypeptide binding]; other site
316056011877	active site
316056011878	excinuclease ABC subunit B; Provisional; Region: PRK05298
316056011879	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316056011880	ATP binding site [chemical binding]; other site
316056011881	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316056011882	nucleotide binding region [chemical binding]; other site
316056011883	ATP-binding site [chemical binding]; other site
316056011884	Ultra-violet resistance protein B; Region: UvrB; pfam12344
316056011885	UvrB/uvrC motif; Region: UVR; pfam02151
316056011886	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
316056011887	ATP binding site [chemical binding]; other site
316056011888	Mg2+ binding site [ion binding]; other site
316056011889	G-X-G motif; other site
316056011890	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
316056011891	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
316056011892	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056011893	non-specific DNA binding site [nucleotide binding]; other site
316056011894	salt bridge; other site
316056011895	sequence-specific DNA binding site [nucleotide binding]; other site
316056011896	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
316056011897	YcfA-like protein; Region: YcfA; pfam07927
316056011898	HipA N-terminal domain; Region: Couple_hipA; cl11853
316056011899	HipA-like N-terminal domain; Region: HipA_N; pfam07805
316056011900	HipA-like C-terminal domain; Region: HipA_C; pfam07804
316056011901	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
316056011902	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056011903	dimer interface [polypeptide binding]; other site
316056011904	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
316056011905	putative CheW interface [polypeptide binding]; other site
316056011906	NADH(P)-binding; Region: NAD_binding_10; pfam13460
316056011907	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
316056011908	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056011909	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
316056011910	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
316056011911	oligomeric interface; other site
316056011912	putative active site [active]
316056011913	homodimer interface [polypeptide binding]; other site
316056011914	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
316056011915	DNA methylase; Region: N6_N4_Mtase; pfam01555
316056011916	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
316056011917	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
316056011918	homotetramer interface [polypeptide binding]; other site
316056011919	ligand binding site [chemical binding]; other site
316056011920	catalytic site [active]
316056011921	NAD binding site [chemical binding]; other site
316056011922	S-adenosylmethionine synthetase; Validated; Region: PRK05250
316056011923	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
316056011924	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
316056011925	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
316056011926	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
316056011927	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
316056011928	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
316056011929	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
316056011930	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
316056011931	substrate binding site [chemical binding]; other site
316056011932	THF binding site; other site
316056011933	zinc-binding site [ion binding]; other site
316056011934	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
316056011935	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
316056011936	putative catalytic motif [active]
316056011937	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
316056011938	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
316056011939	NAD(P) binding site [chemical binding]; other site
316056011940	homodimer interface [polypeptide binding]; other site
316056011941	substrate binding site [chemical binding]; other site
316056011942	active site
316056011943	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
316056011944	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
316056011945	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
316056011946	putative active site [active]
316056011947	putative substrate binding site [chemical binding]; other site
316056011948	putative cosubstrate binding site; other site
316056011949	catalytic site [active]
316056011950	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
316056011951	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
316056011952	active site
316056011953	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
316056011954	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
316056011955	NAD binding site [chemical binding]; other site
316056011956	putative substrate binding site 2 [chemical binding]; other site
316056011957	putative substrate binding site 1 [chemical binding]; other site
316056011958	active site
316056011959	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
316056011960	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
316056011961	putative ligand binding site [chemical binding]; other site
316056011962	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316056011963	TM-ABC transporter signature motif; other site
316056011964	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
316056011965	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316056011966	TM-ABC transporter signature motif; other site
316056011967	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316056011968	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
316056011969	Walker A/P-loop; other site
316056011970	ATP binding site [chemical binding]; other site
316056011971	Q-loop/lid; other site
316056011972	ABC transporter signature motif; other site
316056011973	Walker B; other site
316056011974	D-loop; other site
316056011975	H-loop/switch region; other site
316056011976	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
316056011977	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316056011978	Walker A/P-loop; other site
316056011979	ATP binding site [chemical binding]; other site
316056011980	Q-loop/lid; other site
316056011981	ABC transporter signature motif; other site
316056011982	Walker B; other site
316056011983	D-loop; other site
316056011984	H-loop/switch region; other site
316056011985	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
316056011986	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
316056011987	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056011988	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
316056011989	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
316056011990	Walker A/P-loop; other site
316056011991	ATP binding site [chemical binding]; other site
316056011992	Q-loop/lid; other site
316056011993	ABC transporter signature motif; other site
316056011994	Walker B; other site
316056011995	D-loop; other site
316056011996	H-loop/switch region; other site
316056011997	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
316056011998	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
316056011999	acyl-activating enzyme (AAE) consensus motif; other site
316056012000	putative AMP binding site [chemical binding]; other site
316056012001	putative active site [active]
316056012002	putative CoA binding site [chemical binding]; other site
316056012003	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
316056012004	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
316056012005	TM-ABC transporter signature motif; other site
316056012006	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
316056012007	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
316056012008	TM-ABC transporter signature motif; other site
316056012009	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
316056012010	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
316056012011	putative ligand binding site [chemical binding]; other site
316056012012	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
316056012013	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
316056012014	Walker A/P-loop; other site
316056012015	ATP binding site [chemical binding]; other site
316056012016	Q-loop/lid; other site
316056012017	ABC transporter signature motif; other site
316056012018	Walker B; other site
316056012019	D-loop; other site
316056012020	H-loop/switch region; other site
316056012021	Methyltransferase domain; Region: Methyltransf_23; pfam13489
316056012022	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056012023	S-adenosylmethionine binding site [chemical binding]; other site
316056012024	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
316056012025	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
316056012026	Ligand binding site; other site
316056012027	Putative Catalytic site; other site
316056012028	DXD motif; other site
316056012029	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
316056012030	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316056012031	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
316056012032	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
316056012033	substrate binding site; other site
316056012034	tetramer interface; other site
316056012035	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
316056012036	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
316056012037	NAD binding site [chemical binding]; other site
316056012038	substrate binding site [chemical binding]; other site
316056012039	homodimer interface [polypeptide binding]; other site
316056012040	active site
316056012041	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
316056012042	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
316056012043	NADP binding site [chemical binding]; other site
316056012044	active site
316056012045	putative substrate binding site [chemical binding]; other site
316056012046	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
316056012047	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
316056012048	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
316056012049	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
316056012050	Walker A/P-loop; other site
316056012051	ATP binding site [chemical binding]; other site
316056012052	Q-loop/lid; other site
316056012053	ABC transporter signature motif; other site
316056012054	Walker B; other site
316056012055	D-loop; other site
316056012056	H-loop/switch region; other site
316056012057	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
316056012058	classical (c) SDRs; Region: SDR_c; cd05233
316056012059	NAD(P) binding site [chemical binding]; other site
316056012060	active site
316056012061	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
316056012062	active site
316056012063	NAD binding site [chemical binding]; other site
316056012064	metal binding site [ion binding]; metal-binding site
316056012065	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316056012066	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
316056012067	Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754
316056012068	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316056012069	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
316056012070	Rhamnan synthesis protein F; Region: RgpF; pfam05045
316056012071	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
316056012072	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056012073	NAD(P) binding site [chemical binding]; other site
316056012074	active site
316056012075	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
316056012076	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316056012077	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
316056012078	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316056012079	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
316056012080	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056012081	acyl-activating enzyme (AAE) consensus motif; other site
316056012082	active site
316056012083	AMP binding site [chemical binding]; other site
316056012084	CoA binding site [chemical binding]; other site
316056012085	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
316056012086	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
316056012087	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
316056012088	active site
316056012089	homodimer interface [polypeptide binding]; other site
316056012090	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
316056012091	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316056012092	putative homodimer interface [polypeptide binding]; other site
316056012093	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
316056012094	putative ADP-binding pocket [chemical binding]; other site
316056012095	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
316056012096	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
316056012097	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
316056012098	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
316056012099	classical (c) SDRs; Region: SDR_c; cd05233
316056012100	NAD(P) binding site [chemical binding]; other site
316056012101	active site
316056012102	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
316056012103	FAD binding domain; Region: FAD_binding_4; pfam01565
316056012104	hypothetical protein; Validated; Region: PRK08238
316056012105	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
316056012106	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
316056012107	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
316056012108	Ligand binding site; other site
316056012109	Putative Catalytic site; other site
316056012110	DXD motif; other site
316056012111	FAD binding domain; Region: FAD_binding_4; pfam01565
316056012112	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
316056012113	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
316056012114	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
316056012115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056012116	NAD(P) binding site [chemical binding]; other site
316056012117	active site
316056012118	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
316056012119	extended (e) SDRs; Region: SDR_e; cd08946
316056012120	NAD(P) binding site [chemical binding]; other site
316056012121	active site
316056012122	substrate binding site [chemical binding]; other site
316056012123	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
316056012124	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
316056012125	substrate binding site; other site
316056012126	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
316056012127	Methyltransferase domain; Region: Methyltransf_23; pfam13489
316056012128	Methyltransferase domain; Region: Methyltransf_12; pfam08242
316056012129	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
316056012130	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
316056012131	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056012132	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
316056012133	NAD(P) binding site [chemical binding]; other site
316056012134	active site
316056012135	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
316056012136	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056012137	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316056012138	putative substrate translocation pore; other site
316056012139	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
316056012140	FHIPEP family; Region: FHIPEP; pfam00771
316056012141	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
316056012142	Anti-sigma-K factor rskA; Region: RskA; pfam10099
316056012143	RNA polymerase sigma factor; Provisional; Region: PRK12514
316056012144	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
316056012145	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
316056012146	DNA binding residues [nucleotide binding]
316056012147	AAA domain; Region: AAA_13; pfam13166
316056012148	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
316056012149	adenosine deaminase; Provisional; Region: PRK09358
316056012150	active site
316056012151	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
316056012152	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
316056012153	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
316056012154	Walker A motif/ATP binding site; other site
316056012155	Walker B motif; other site
316056012156	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316056012157	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056012158	active site
316056012159	phosphorylation site [posttranslational modification]
316056012160	intermolecular recognition site; other site
316056012161	dimerization interface [polypeptide binding]; other site
316056012162	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056012163	DNA binding site [nucleotide binding]
316056012164	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
316056012165	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
316056012166	Substrate binding site; other site
316056012167	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
316056012168	Predicted membrane protein [Function unknown]; Region: COG2246
316056012169	GtrA-like protein; Region: GtrA; pfam04138
316056012170	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
316056012171	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
316056012172	Ligand binding site; other site
316056012173	Putative Catalytic site; other site
316056012174	DXD motif; other site
316056012175	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
316056012176	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
316056012177	active site
316056012178	substrate binding site [chemical binding]; other site
316056012179	metal binding site [ion binding]; metal-binding site
316056012180	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
316056012181	dimerization interface [polypeptide binding]; other site
316056012182	putative active cleft [active]
316056012183	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
316056012184	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
316056012185	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
316056012186	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
316056012187	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
316056012188	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
316056012189	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056012190	active site
316056012191	phosphorylation site [posttranslational modification]
316056012192	intermolecular recognition site; other site
316056012193	dimerization interface [polypeptide binding]; other site
316056012194	CheB methylesterase; Region: CheB_methylest; pfam01339
316056012195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056012196	Response regulator receiver domain; Region: Response_reg; pfam00072
316056012197	active site
316056012198	phosphorylation site [posttranslational modification]
316056012199	intermolecular recognition site; other site
316056012200	dimerization interface [polypeptide binding]; other site
316056012201	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
316056012202	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
316056012203	putative binding surface; other site
316056012204	active site
316056012205	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
316056012206	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
316056012207	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056012208	ATP binding site [chemical binding]; other site
316056012209	Mg2+ binding site [ion binding]; other site
316056012210	G-X-G motif; other site
316056012211	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
316056012212	Response regulator receiver domain; Region: Response_reg; pfam00072
316056012213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056012214	active site
316056012215	phosphorylation site [posttranslational modification]
316056012216	intermolecular recognition site; other site
316056012217	dimerization interface [polypeptide binding]; other site
316056012218	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
316056012219	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
316056012220	active site
316056012221	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
316056012222	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
316056012223	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
316056012224	ABC-ATPase subunit  interface; other site
316056012225	dimer interface [polypeptide binding]; other site
316056012226	putative PBP binding regions; other site
316056012227	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
316056012228	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
316056012229	Walker A/P-loop; other site
316056012230	ATP binding site [chemical binding]; other site
316056012231	Q-loop/lid; other site
316056012232	ABC transporter signature motif; other site
316056012233	Walker B; other site
316056012234	D-loop; other site
316056012235	H-loop/switch region; other site
316056012236	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
316056012237	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cd00636
316056012238	intersubunit interface [polypeptide binding]; other site
316056012239	cobyric acid synthase; Provisional; Region: PRK00784
316056012240	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
316056012241	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
316056012242	catalytic triad [active]
316056012243	Cysteine-rich small domain; Region: zf-like; cl00946
316056012244	hypothetical protein; Validated; Region: PRK07586
316056012245	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
316056012246	PYR/PP interface [polypeptide binding]; other site
316056012247	dimer interface [polypeptide binding]; other site
316056012248	TPP binding site [chemical binding]; other site
316056012249	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
316056012250	TPP-binding site [chemical binding]; other site
316056012251	dimer interface [polypeptide binding]; other site
316056012252	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
316056012253	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316056012254	Protein of unknown function (DUF2927); Region: DUF2927; pfam11150
316056012255	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
316056012256	isovaleryl-CoA dehydrogenase; Region: PLN02519
316056012257	substrate binding site [chemical binding]; other site
316056012258	FAD binding site [chemical binding]; other site
316056012259	catalytic base [active]
316056012260	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
316056012261	Cytochrome P450; Region: p450; cl12078
316056012262	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
316056012263	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
316056012264	active site
316056012265	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
316056012266	CoA-transferase family III; Region: CoA_transf_3; pfam02515
316056012267	Uncharacterized conserved protein [Function unknown]; Region: COG3777
316056012268	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
316056012269	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
316056012270	active site 2 [active]
316056012271	active site 1 [active]
316056012272	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
316056012273	classical (c) SDRs; Region: SDR_c; cd05233
316056012274	NAD(P) binding site [chemical binding]; other site
316056012275	active site
316056012276	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
316056012277	YcjX-like family, DUF463; Region: DUF463; pfam04317
316056012278	hypothetical protein; Provisional; Region: PRK05415
316056012279	Domain of unknown function (DUF697); Region: DUF697; cl12064
316056012280	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
316056012281	DNA-binding site [nucleotide binding]; DNA binding site
316056012282	RNA-binding motif; other site
316056012283	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
316056012284	Proline dehydrogenase; Region: Pro_dh; pfam01619
316056012285	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
316056012286	Glutamate binding site [chemical binding]; other site
316056012287	NAD binding site [chemical binding]; other site
316056012288	catalytic residues [active]
316056012289	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
316056012290	Peptidase family M23; Region: Peptidase_M23; pfam01551
316056012291	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
316056012292	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
316056012293	PQQ-like domain; Region: PQQ_2; pfam13360
316056012294	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
316056012295	Clp amino terminal domain; Region: Clp_N; pfam02861
316056012296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056012297	Walker A motif; other site
316056012298	ATP binding site [chemical binding]; other site
316056012299	Walker B motif; other site
316056012300	arginine finger; other site
316056012301	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056012302	Walker A motif; other site
316056012303	ATP binding site [chemical binding]; other site
316056012304	Walker B motif; other site
316056012305	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
316056012306	TIGR02594 family protein; Region: TIGR02594
316056012307	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
316056012308	Methyltransferase domain; Region: Methyltransf_23; pfam13489
316056012309	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056012310	S-adenosylmethionine binding site [chemical binding]; other site
316056012311	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
316056012312	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
316056012313	hypothetical protein; Provisional; Region: PRK06034
316056012314	Chorismate mutase type II; Region: CM_2; pfam01817
316056012315	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
316056012316	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316056012317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056012318	homodimer interface [polypeptide binding]; other site
316056012319	catalytic residue [active]
316056012320	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
316056012321	prephenate dehydrogenase; Validated; Region: PRK08507
316056012322	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
316056012323	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
316056012324	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056012325	NAD(P) binding site [chemical binding]; other site
316056012326	active site
316056012327	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
316056012328	putative active site [active]
316056012329	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
316056012330	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
316056012331	Cl binding site [ion binding]; other site
316056012332	oligomer interface [polypeptide binding]; other site
316056012333	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
316056012334	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316056012335	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
316056012336	putative acyl-CoA synthetase; Provisional; Region: PRK06018
316056012337	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
316056012338	dimer interface [polypeptide binding]; other site
316056012339	acyl-activating enzyme (AAE) consensus motif; other site
316056012340	putative active site [active]
316056012341	AMP binding site [chemical binding]; other site
316056012342	putative CoA binding site [chemical binding]; other site
316056012343	Acyltransferase family; Region: Acyl_transf_3; pfam01757
316056012344	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
316056012345	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
316056012346	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
316056012347	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
316056012348	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
316056012349	FAD binding site [chemical binding]; other site
316056012350	substrate binding pocket [chemical binding]; other site
316056012351	catalytic base [active]
316056012352	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
316056012353	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
316056012354	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
316056012355	dimerization interface [polypeptide binding]; other site
316056012356	active site
316056012357	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
316056012358	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
316056012359	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
316056012360	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
316056012361	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056012362	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056012363	ligand binding site [chemical binding]; other site
316056012364	flexible hinge region; other site
316056012365	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
316056012366	non-specific DNA interactions [nucleotide binding]; other site
316056012367	DNA binding site [nucleotide binding]
316056012368	sequence specific DNA binding site [nucleotide binding]; other site
316056012369	putative cAMP binding site [chemical binding]; other site
316056012370	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
316056012371	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
316056012372	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
316056012373	protein binding site [polypeptide binding]; other site
316056012374	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
316056012375	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
316056012376	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
316056012377	additional DNA contacts [nucleotide binding]; other site
316056012378	mismatch recognition site; other site
316056012379	active site
316056012380	zinc binding site [ion binding]; other site
316056012381	DNA intercalation site [nucleotide binding]; other site
316056012382	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
316056012383	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
316056012384	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
316056012385	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
316056012386	cofactor binding site; other site
316056012387	DNA binding site [nucleotide binding]
316056012388	substrate interaction site [chemical binding]; other site
316056012389	sensor protein PhoQ; Provisional; Region: PRK10815
316056012390	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056012391	ATP binding site [chemical binding]; other site
316056012392	Mg2+ binding site [ion binding]; other site
316056012393	G-X-G motif; other site
316056012394	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316056012395	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056012396	active site
316056012397	phosphorylation site [posttranslational modification]
316056012398	intermolecular recognition site; other site
316056012399	dimerization interface [polypeptide binding]; other site
316056012400	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056012401	DNA binding site [nucleotide binding]
316056012402	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
316056012403	ArsC family; Region: ArsC; pfam03960
316056012404	putative catalytic residues [active]
316056012405	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
316056012406	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
316056012407	molybdenum transport protein ModD; Provisional; Region: PRK06096
316056012408	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
316056012409	active site
316056012410	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
316056012411	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
316056012412	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
316056012413	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
316056012414	FAD binding domain; Region: FAD_binding_4; pfam01565
316056012415	putative acetyltransferase; Provisional; Region: PRK03624
316056012416	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056012417	Coenzyme A binding pocket [chemical binding]; other site
316056012418	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
316056012419	Uncharacterized conserved protein [Function unknown]; Region: COG2135
316056012420	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
316056012421	nudix motif; other site
316056012422	TIGR02301 family protein; Region: TIGR02301
316056012423	dihydroorotase; Validated; Region: PRK09060
316056012424	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
316056012425	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
316056012426	active site
316056012427	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
316056012428	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
316056012429	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
316056012430	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
316056012431	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
316056012432	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
316056012433	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
316056012434	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
316056012435	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
316056012436	NADP binding site [chemical binding]; other site
316056012437	dimer interface [polypeptide binding]; other site
316056012438	quinolinate synthetase; Provisional; Region: PRK09375
316056012439	L-aspartate oxidase; Provisional; Region: PRK07512
316056012440	L-aspartate oxidase; Provisional; Region: PRK06175
316056012441	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
316056012442	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
316056012443	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
316056012444	dimerization interface [polypeptide binding]; other site
316056012445	active site
316056012446	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
316056012447	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
316056012448	pyruvate phosphate dikinase; Provisional; Region: PRK09279
316056012449	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
316056012450	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
316056012451	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
316056012452	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
316056012453	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
316056012454	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
316056012455	dimer interface [polypeptide binding]; other site
316056012456	motif 1; other site
316056012457	active site
316056012458	motif 2; other site
316056012459	motif 3; other site
316056012460	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
316056012461	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
316056012462	tandem repeat interface [polypeptide binding]; other site
316056012463	oligomer interface [polypeptide binding]; other site
316056012464	active site residues [active]
316056012465	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
316056012466	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
316056012467	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
316056012468	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
316056012469	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
316056012470	substrate binding pocket [chemical binding]; other site
316056012471	chain length determination region; other site
316056012472	substrate-Mg2+ binding site; other site
316056012473	catalytic residues [active]
316056012474	aspartate-rich region 1; other site
316056012475	active site lid residues [active]
316056012476	aspartate-rich region 2; other site
316056012477	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
316056012478	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056012479	binding surface
316056012480	TPR motif; other site
316056012481	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
316056012482	binding surface
316056012483	TPR motif; other site
316056012484	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056012485	binding surface
316056012486	TPR motif; other site
316056012487	TPR repeat; Region: TPR_11; pfam13414
316056012488	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056012489	binding surface
316056012490	TPR motif; other site
316056012491	TPR repeat; Region: TPR_11; pfam13414
316056012492	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
316056012493	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
316056012494	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
316056012495	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
316056012496	Fe-S cluster binding site [ion binding]; other site
316056012497	active site
316056012498	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
316056012499	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
316056012500	RNA/DNA hybrid binding site [nucleotide binding]; other site
316056012501	active site
316056012502	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
316056012503	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056012504	FeS/SAM binding site; other site
316056012505	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
316056012506	active site
316056012507	Transcriptional regulators [Transcription]; Region: MarR; COG1846
316056012508	MarR family; Region: MarR_2; pfam12802
316056012509	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056012510	Coenzyme A binding pocket [chemical binding]; other site
316056012511	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
316056012512	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
316056012513	DNA methylase; Region: N6_N4_Mtase; pfam01555
316056012514	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
316056012515	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
316056012516	minor groove reading motif; other site
316056012517	helix-hairpin-helix signature motif; other site
316056012518	substrate binding pocket [chemical binding]; other site
316056012519	active site
316056012520	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
316056012521	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
316056012522	DNA binding and oxoG recognition site [nucleotide binding]
316056012523	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
316056012524	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
316056012525	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056012526	non-specific DNA binding site [nucleotide binding]; other site
316056012527	salt bridge; other site
316056012528	sequence-specific DNA binding site [nucleotide binding]; other site
316056012529	Protein of unknown function (DUF721); Region: DUF721; cl02324
316056012530	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
316056012531	Thioredoxin; Region: Thioredoxin_4; pfam13462
316056012532	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
316056012533	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
316056012534	AAA domain; Region: AAA_23; pfam13476
316056012535	Walker A/P-loop; other site
316056012536	ATP binding site [chemical binding]; other site
316056012537	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
316056012538	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
316056012539	ABC transporter signature motif; other site
316056012540	Walker B; other site
316056012541	D-loop; other site
316056012542	H-loop/switch region; other site
316056012543	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
316056012544	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
316056012545	Peptidase family M48; Region: Peptidase_M48; cl12018
316056012546	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
316056012547	Dehydratase family; Region: ILVD_EDD; pfam00920
316056012548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056012549	D-galactonate transporter; Region: 2A0114; TIGR00893
316056012550	putative substrate translocation pore; other site
316056012551	dihydrodipicolinate synthase; Region: dapA; TIGR00674
316056012552	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
316056012553	inhibitor site; inhibition site
316056012554	active site
316056012555	dimer interface [polypeptide binding]; other site
316056012556	catalytic residue [active]
316056012557	Transcriptional regulator [Transcription]; Region: IclR; COG1414
316056012558	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
316056012559	Bacterial transcriptional regulator; Region: IclR; pfam01614
316056012560	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
316056012561	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
316056012562	active site
316056012563	anthranilate synthase; Provisional; Region: PRK13566
316056012564	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
316056012565	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
316056012566	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
316056012567	glutamine binding [chemical binding]; other site
316056012568	catalytic triad [active]
316056012569	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
316056012570	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
316056012571	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
316056012572	PhnA protein; Region: PhnA; pfam03831
316056012573	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
316056012574	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
316056012575	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
316056012576	acyl-activating enzyme (AAE) consensus motif; other site
316056012577	putative AMP binding site [chemical binding]; other site
316056012578	putative active site [active]
316056012579	putative CoA binding site [chemical binding]; other site
316056012580	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
316056012581	TPR repeat; Region: TPR_11; pfam13414
316056012582	binding surface
316056012583	TPR motif; other site
316056012584	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
316056012585	Domain of unknown function (DUF1850); Region: DUF1850; pfam08905
316056012586	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
316056012587	DctM-like transporters; Region: DctM; pfam06808
316056012588	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
316056012589	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
316056012590	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316056012591	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056012592	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
316056012593	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056012594	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056012595	dimerization interface [polypeptide binding]; other site
316056012596	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056012597	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056012598	dimer interface [polypeptide binding]; other site
316056012599	putative CheW interface [polypeptide binding]; other site
316056012600	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056012601	dimerization interface [polypeptide binding]; other site
316056012602	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056012603	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056012604	dimer interface [polypeptide binding]; other site
316056012605	putative CheW interface [polypeptide binding]; other site
316056012606	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
316056012607	Histidine kinase; Region: HisKA_2; pfam07568
316056012608	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056012609	ATP binding site [chemical binding]; other site
316056012610	Mg2+ binding site [ion binding]; other site
316056012611	G-X-G motif; other site
316056012612	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
316056012613	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056012614	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
316056012615	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056012616	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056012617	ligand binding site [chemical binding]; other site
316056012618	flexible hinge region; other site
316056012619	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
316056012620	non-specific DNA interactions [nucleotide binding]; other site
316056012621	DNA binding site [nucleotide binding]
316056012622	sequence specific DNA binding site [nucleotide binding]; other site
316056012623	putative cAMP binding site [chemical binding]; other site
316056012624	EamA-like transporter family; Region: EamA; pfam00892
316056012625	zinc-binding protein; Provisional; Region: PRK01343
316056012626	Maf-like protein; Region: Maf; pfam02545
316056012627	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
316056012628	active site
316056012629	dimer interface [polypeptide binding]; other site
316056012630	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
316056012631	Low molecular weight phosphatase family; Region: LMWPc; cd00115
316056012632	active site
316056012633	hypothetical protein; Provisional; Region: PRK02853
316056012634	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
316056012635	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
316056012636	NAD binding site [chemical binding]; other site
316056012637	dimerization interface [polypeptide binding]; other site
316056012638	product binding site; other site
316056012639	substrate binding site [chemical binding]; other site
316056012640	zinc binding site [ion binding]; other site
316056012641	catalytic residues [active]
316056012642	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
316056012643	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
316056012644	hinge; other site
316056012645	active site
316056012646	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056012647	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
316056012648	NAD(P) binding site [chemical binding]; other site
316056012649	active site
316056012650	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
316056012651	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
316056012652	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056012653	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056012654	ligand binding site [chemical binding]; other site
316056012655	flexible hinge region; other site
316056012656	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
316056012657	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
316056012658	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
316056012659	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
316056012660	PIN domain; Region: PIN_3; pfam13470
316056012661	Helix-turn-helix domain; Region: HTH_17; cl17695
316056012662	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
316056012663	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
316056012664	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
316056012665	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
316056012666	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
316056012667	Protein of unknown function, DUF1537; Region: DUF1537; pfam07005
316056012668	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
316056012669	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
316056012670	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
316056012671	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
316056012672	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056012673	dimer interface [polypeptide binding]; other site
316056012674	conserved gate region; other site
316056012675	putative PBP binding loops; other site
316056012676	ABC-ATPase subunit interface; other site
316056012677	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
316056012678	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
316056012679	substrate binding pocket [chemical binding]; other site
316056012680	membrane-bound complex binding site; other site
316056012681	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
316056012682	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
316056012683	Walker A/P-loop; other site
316056012684	ATP binding site [chemical binding]; other site
316056012685	Q-loop/lid; other site
316056012686	ABC transporter signature motif; other site
316056012687	Walker B; other site
316056012688	D-loop; other site
316056012689	H-loop/switch region; other site
316056012690	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
316056012691	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
316056012692	trimer interface [polypeptide binding]; other site
316056012693	active site
316056012694	substrate binding site [chemical binding]; other site
316056012695	CoA binding site [chemical binding]; other site
316056012696	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
316056012697	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
316056012698	active site
316056012699	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
316056012700	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
316056012701	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
316056012702	active site
316056012703	Ap6A binding site [chemical binding]; other site
316056012704	nudix motif; other site
316056012705	metal binding site [ion binding]; metal-binding site
316056012706	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
316056012707	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
316056012708	NAD binding site [chemical binding]; other site
316056012709	homodimer interface [polypeptide binding]; other site
316056012710	active site
316056012711	substrate binding site [chemical binding]; other site
316056012712	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
316056012713	Transposase; Region: DEDD_Tnp_IS110; pfam01548
316056012714	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
316056012715	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
316056012716	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
316056012717	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
316056012718	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
316056012719	dimer interface [polypeptide binding]; other site
316056012720	decamer (pentamer of dimers) interface [polypeptide binding]; other site
316056012721	catalytic triad [active]
316056012722	peroxidatic and resolving cysteines [active]
316056012723	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
316056012724	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
316056012725	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
316056012726	oxidoreductase; Provisional; Region: PRK10015
316056012727	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
316056012728	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
316056012729	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
316056012730	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
316056012731	Ligand binding site [chemical binding]; other site
316056012732	Electron transfer flavoprotein domain; Region: ETF; pfam01012
316056012733	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810
316056012734	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
316056012735	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
316056012736	active site
316056012737	catalytic residues [active]
316056012738	metal binding site [ion binding]; metal-binding site
316056012739	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
316056012740	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
316056012741	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316056012742	catalytic residue [active]
316056012743	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
316056012744	trimerization site [polypeptide binding]; other site
316056012745	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
316056012746	active site
316056012747	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
316056012748	NifU-like domain; Region: NifU; pfam01106
316056012749	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
316056012750	NifQ; Region: NifQ; pfam04891
316056012751	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
316056012752	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
316056012753	Rop-like; Region: Rop-like; pfam05082
316056012754	probable nitrogen fixation protein; Region: TIGR02935
316056012755	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
316056012756	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
316056012757	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
316056012758	nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478
316056012759	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
316056012760	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
316056012761	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
316056012762	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
316056012763	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
316056012764	MoFe protein beta/alpha subunit interactions; other site
316056012765	Beta subunit P cluster binding residues; other site
316056012766	MoFe protein beta subunit/Fe protein contacts; other site
316056012767	MoFe protein dimer/ dimer interactions; other site
316056012768	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
316056012769	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
316056012770	MoFe protein alpha/beta subunit interactions; other site
316056012771	Alpha subunit P cluster binding residues; other site
316056012772	FeMoco binding residues [chemical binding]; other site
316056012773	MoFe protein alpha subunit/Fe protein contacts; other site
316056012774	MoFe protein dimer/ dimer interactions; other site
316056012775	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
316056012776	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
316056012777	Nucleotide-binding sites [chemical binding]; other site
316056012778	Walker A motif; other site
316056012779	Switch I region of nucleotide binding site; other site
316056012780	Fe4S4 binding sites [ion binding]; other site
316056012781	Switch II region of nucleotide binding site; other site
316056012782	SIR2-like domain; Region: SIR2_2; pfam13289
316056012783	NifT/FixU protein; Region: NifT; pfam06988
316056012784	NifZ domain; Region: NifZ; pfam04319
316056012785	NifZ domain; Region: NifZ; pfam04319
316056012786	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
316056012787	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
316056012788	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
316056012789	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056012790	FeS/SAM binding site; other site
316056012791	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
316056012792	archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700
316056012793	Nif-specific regulatory protein; Region: nifA; TIGR01817
316056012794	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
316056012795	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056012796	Walker A motif; other site
316056012797	ATP binding site [chemical binding]; other site
316056012798	Walker B motif; other site
316056012799	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
316056012800	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
316056012801	classical (c) SDRs; Region: SDR_c; cd05233
316056012802	NAD(P) binding site [chemical binding]; other site
316056012803	active site
316056012804	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
316056012805	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
316056012806	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
316056012807	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
316056012808	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056012809	FeS/SAM binding site; other site
316056012810	enoyl-CoA hydratase; Provisional; Region: PRK06494
316056012811	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
316056012812	substrate binding site [chemical binding]; other site
316056012813	oxyanion hole (OAH) forming residues; other site
316056012814	trimer interface [polypeptide binding]; other site
316056012815	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
316056012816	cyclase homology domain; Region: CHD; cd07302
316056012817	nucleotidyl binding site; other site
316056012818	metal binding site [ion binding]; metal-binding site
316056012819	dimer interface [polypeptide binding]; other site
316056012820	AAA ATPase domain; Region: AAA_16; pfam13191
316056012821	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
316056012822	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
316056012823	putative catalytic cysteine [active]
316056012824	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
316056012825	putative active site [active]
316056012826	metal binding site [ion binding]; metal-binding site
316056012827	HerA helicase [Replication, recombination, and repair]; Region: COG0433
316056012828	Predicted methyltransferase [General function prediction only]; Region: COG4798
316056012829	Methyltransferase domain; Region: Methyltransf_23; pfam13489
316056012830	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
316056012831	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
316056012832	N-terminal plug; other site
316056012833	ligand-binding site [chemical binding]; other site
316056012834	Suppression of tumorigenicity 7; Region: ST7; cd11557
316056012835	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
316056012836	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
316056012837	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
316056012838	Integrase core domain; Region: rve; pfam00665
316056012839	transposase; Validated; Region: PRK08181
316056012840	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056012841	Walker A motif; other site
316056012842	ATP binding site [chemical binding]; other site
316056012843	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
316056012844	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056012845	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056012846	ligand binding site [chemical binding]; other site
316056012847	flexible hinge region; other site
316056012848	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
316056012849	putative switch regulator; other site
316056012850	non-specific DNA interactions [nucleotide binding]; other site
316056012851	DNA binding site [nucleotide binding]
316056012852	sequence specific DNA binding site [nucleotide binding]; other site
316056012853	putative cAMP binding site [chemical binding]; other site
316056012854	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
316056012855	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
316056012856	P-loop; other site
316056012857	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
316056012858	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
316056012859	ACS interaction site; other site
316056012860	CODH interaction site; other site
316056012861	cubane metal cluster (B-cluster) [ion binding]; other site
316056012862	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
316056012863	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
316056012864	4Fe-4S binding domain; Region: Fer4; pfam00037
316056012865	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
316056012866	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
316056012867	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
316056012868	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
316056012869	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
316056012870	hydrogenase 4 subunit H; Validated; Region: PRK08222
316056012871	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
316056012872	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
316056012873	NADH dehydrogenase; Region: NADHdh; cl00469
316056012874	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
316056012875	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056012876	NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00196
316056012877	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056012878	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056012879	Transposase IS200 like; Region: Y1_Tnp; pfam01797
316056012880	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
316056012881	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056012882	dimer interface [polypeptide binding]; other site
316056012883	phosphorylation site [posttranslational modification]
316056012884	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056012885	ATP binding site [chemical binding]; other site
316056012886	Mg2+ binding site [ion binding]; other site
316056012887	G-X-G motif; other site
316056012888	Response regulator receiver domain; Region: Response_reg; pfam00072
316056012889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056012890	active site
316056012891	phosphorylation site [posttranslational modification]
316056012892	intermolecular recognition site; other site
316056012893	dimerization interface [polypeptide binding]; other site
316056012894	Response regulator receiver domain; Region: Response_reg; pfam00072
316056012895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056012896	active site
316056012897	phosphorylation site [posttranslational modification]
316056012898	intermolecular recognition site; other site
316056012899	dimerization interface [polypeptide binding]; other site
316056012900	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
316056012901	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
316056012902	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056012903	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056012904	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
316056012905	Walker A/P-loop; other site
316056012906	ATP binding site [chemical binding]; other site
316056012907	Q-loop/lid; other site
316056012908	ABC transporter signature motif; other site
316056012909	Walker B; other site
316056012910	D-loop; other site
316056012911	H-loop/switch region; other site
316056012912	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
316056012913	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
316056012914	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056012915	Walker A/P-loop; other site
316056012916	ATP binding site [chemical binding]; other site
316056012917	Q-loop/lid; other site
316056012918	ABC transporter signature motif; other site
316056012919	Walker B; other site
316056012920	D-loop; other site
316056012921	H-loop/switch region; other site
316056012922	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056012923	PAS domain; Region: PAS_9; pfam13426
316056012924	putative active site [active]
316056012925	heme pocket [chemical binding]; other site
316056012926	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056012927	PAS domain; Region: PAS_9; pfam13426
316056012928	putative active site [active]
316056012929	heme pocket [chemical binding]; other site
316056012930	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056012931	PAS domain; Region: PAS_9; pfam13426
316056012932	putative active site [active]
316056012933	heme pocket [chemical binding]; other site
316056012934	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056012935	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056012936	dimer interface [polypeptide binding]; other site
316056012937	putative CheW interface [polypeptide binding]; other site
316056012938	Conjugal transfer protein TraD; Region: TraD; pfam06412
316056012939	Conjugal transfer protein TraD; Region: TraD; pfam06412
316056012940	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
316056012941	MobA/MobL family; Region: MobA_MobL; pfam03389
316056012942	AAA domain; Region: AAA_30; pfam13604
316056012943	Family description; Region: UvrD_C_2; pfam13538
316056012944	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
316056012945	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
316056012946	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
316056012947	active site
316056012948	Int/Topo IB signature motif; other site
316056012949	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
316056012950	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
316056012951	active site
316056012952	homotetramer interface [polypeptide binding]; other site
316056012953	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
316056012954	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
316056012955	benzoate transport; Region: 2A0115; TIGR00895
316056012956	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056012957	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
316056012958	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
316056012959	dimerization interface [polypeptide binding]; other site
316056012960	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056012961	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056012962	dimer interface [polypeptide binding]; other site
316056012963	putative CheW interface [polypeptide binding]; other site
316056012964	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
316056012965	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316056012966	catalytic loop [active]
316056012967	iron binding site [ion binding]; other site
316056012968	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
316056012969	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
316056012970	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
316056012971	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
316056012972	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
316056012973	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
316056012974	FAD binding domain; Region: FAD_binding_4; pfam01565
316056012975	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
316056012976	urea carboxylase; Region: urea_carbox; TIGR02712
316056012977	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
316056012978	ATP-grasp domain; Region: ATP-grasp_4; cl17255
316056012979	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
316056012980	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
316056012981	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
316056012982	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
316056012983	carboxyltransferase (CT) interaction site; other site
316056012984	biotinylation site [posttranslational modification]; other site
316056012985	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
316056012986	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
316056012987	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
316056012988	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
316056012989	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
316056012990	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
316056012991	Walker A/P-loop; other site
316056012992	ATP binding site [chemical binding]; other site
316056012993	Q-loop/lid; other site
316056012994	ABC transporter signature motif; other site
316056012995	Walker B; other site
316056012996	D-loop; other site
316056012997	H-loop/switch region; other site
316056012998	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
316056012999	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056013000	dimer interface [polypeptide binding]; other site
316056013001	conserved gate region; other site
316056013002	putative PBP binding loops; other site
316056013003	ABC-ATPase subunit interface; other site
316056013004	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
316056013005	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
316056013006	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
316056013007	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
316056013008	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
316056013009	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
316056013010	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
316056013011	SecA DEAD-like domain; Region: SecA_DEAD; smart00957
316056013012	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
316056013013	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
316056013014	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316056013015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056013016	active site
316056013017	phosphorylation site [posttranslational modification]
316056013018	intermolecular recognition site; other site
316056013019	dimerization interface [polypeptide binding]; other site
316056013020	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056013021	DNA binding site [nucleotide binding]
316056013022	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
316056013023	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
316056013024	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
316056013025	Ligand Binding Site [chemical binding]; other site
316056013026	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
316056013027	GAF domain; Region: GAF_3; pfam13492
316056013028	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056013029	dimer interface [polypeptide binding]; other site
316056013030	phosphorylation site [posttranslational modification]
316056013031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056013032	ATP binding site [chemical binding]; other site
316056013033	Mg2+ binding site [ion binding]; other site
316056013034	G-X-G motif; other site
316056013035	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
316056013036	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
316056013037	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
316056013038	Soluble P-type ATPase [General function prediction only]; Region: COG4087
316056013039	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
316056013040	hypothetical protein; Provisional; Region: PRK04233
316056013041	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
316056013042	MPT binding site; other site
316056013043	trimer interface [polypeptide binding]; other site
316056013044	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
316056013045	Acylphosphatase; Region: Acylphosphatase; pfam00708
316056013046	HypF finger; Region: zf-HYPF; pfam07503
316056013047	HypF finger; Region: zf-HYPF; pfam07503
316056013048	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
316056013049	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
316056013050	dimerization interface [polypeptide binding]; other site
316056013051	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
316056013052	ATP binding site [chemical binding]; other site
316056013053	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
316056013054	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
316056013055	HupF/HypC family; Region: HupF_HypC; pfam01455
316056013056	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
316056013057	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056013058	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056013059	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
316056013060	dimerization interface [polypeptide binding]; other site
316056013061	HupF/HypC family; Region: HupF_HypC; pfam01455
316056013062	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
316056013063	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
316056013064	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
316056013065	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056013066	FeS/SAM binding site; other site
316056013067	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
316056013068	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
316056013069	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
316056013070	nickel binding site [ion binding]; other site
316056013071	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
316056013072	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
316056013073	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
316056013074	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
316056013075	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
316056013076	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
316056013077	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
316056013078	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
316056013079	hydrogenase 4 subunit F; Validated; Region: PRK06458
316056013080	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056013081	hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492
316056013082	hydrogenase 4 subunit D; Validated; Region: PRK06525
316056013083	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056013084	NADH dehydrogenase; Region: NADHdh; cl00469
316056013085	hydrogenase 4 subunit B; Validated; Region: PRK06521
316056013086	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
316056013087	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
316056013088	4Fe-4S binding domain; Region: Fer4; cl02805
316056013089	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
316056013090	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
316056013091	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
316056013092	[4Fe-4S] binding site [ion binding]; other site
316056013093	molybdopterin cofactor binding site; other site
316056013094	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
316056013095	molybdopterin cofactor binding site; other site
316056013096	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
316056013097	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
316056013098	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
316056013099	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056013100	dimer interface [polypeptide binding]; other site
316056013101	putative CheW interface [polypeptide binding]; other site
316056013102	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056013103	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056013104	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
316056013105	putative effector binding pocket; other site
316056013106	dimerization interface [polypeptide binding]; other site
316056013107	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
316056013108	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
316056013109	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
316056013110	MgtE intracellular N domain; Region: MgtE_N; pfam03448
316056013111	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
316056013112	malate dehydrogenase; Reviewed; Region: PRK06223
316056013113	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
316056013114	NAD(P) binding site [chemical binding]; other site
316056013115	dimer interface [polypeptide binding]; other site
316056013116	tetramer (dimer of dimers) interface [polypeptide binding]; other site
316056013117	substrate binding site [chemical binding]; other site
316056013118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056013119	D-galactonate transporter; Region: 2A0114; TIGR00893
316056013120	putative substrate translocation pore; other site
316056013121	Membrane transport protein; Region: Mem_trans; pfam03547
316056013122	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
316056013123	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
316056013124	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
316056013125	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
316056013126	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
316056013127	malonate decarboxylase, beta subunit; Region: malonate_beta; TIGR03133
316056013128	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
316056013129	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
316056013130	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
316056013131	Coenzyme A transferase; Region: CoA_trans; cl17247
316056013132	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
316056013133	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056013134	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
316056013135	dimerization interface [polypeptide binding]; other site
316056013136	substrate binding pocket [chemical binding]; other site
316056013137	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056013138	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
316056013139	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
316056013140	dimerization interface [polypeptide binding]; other site
316056013141	substrate binding pocket [chemical binding]; other site
316056013142	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
316056013143	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
316056013144	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
316056013145	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
316056013146	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
316056013147	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
316056013148	acyl-activating enzyme (AAE) consensus motif; other site
316056013149	AMP binding site [chemical binding]; other site
316056013150	active site
316056013151	CoA binding site [chemical binding]; other site
316056013152	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056013153	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
316056013154	putative active site [active]
316056013155	heme pocket [chemical binding]; other site
316056013156	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056013157	putative active site [active]
316056013158	heme pocket [chemical binding]; other site
316056013159	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056013160	dimer interface [polypeptide binding]; other site
316056013161	phosphorylation site [posttranslational modification]
316056013162	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056013163	ATP binding site [chemical binding]; other site
316056013164	Mg2+ binding site [ion binding]; other site
316056013165	G-X-G motif; other site
316056013166	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
316056013167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056013168	active site
316056013169	phosphorylation site [posttranslational modification]
316056013170	intermolecular recognition site; other site
316056013171	dimerization interface [polypeptide binding]; other site
316056013172	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
316056013173	Chemotaxis phosphatase CheX; Region: CheX; cl15816
316056013174	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
316056013175	Response regulator receiver domain; Region: Response_reg; pfam00072
316056013176	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056013177	active site
316056013178	phosphorylation site [posttranslational modification]
316056013179	intermolecular recognition site; other site
316056013180	dimerization interface [polypeptide binding]; other site
316056013181	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
316056013182	putative binding surface; other site
316056013183	active site
316056013184	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
316056013185	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056013186	ATP binding site [chemical binding]; other site
316056013187	Mg2+ binding site [ion binding]; other site
316056013188	G-X-G motif; other site
316056013189	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
316056013190	Response regulator receiver domain; Region: Response_reg; pfam00072
316056013191	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056013192	active site
316056013193	phosphorylation site [posttranslational modification]
316056013194	intermolecular recognition site; other site
316056013195	dimerization interface [polypeptide binding]; other site
316056013196	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
316056013197	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
316056013198	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
316056013199	HEAT repeats; Region: HEAT_2; pfam13646
316056013200	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
316056013201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056013202	active site
316056013203	phosphorylation site [posttranslational modification]
316056013204	intermolecular recognition site; other site
316056013205	dimerization interface [polypeptide binding]; other site
316056013206	CheB methylesterase; Region: CheB_methylest; pfam01339
316056013207	CheW-like domain; Region: CheW; pfam01584
316056013208	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
316056013209	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
316056013210	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056013211	dimer interface [polypeptide binding]; other site
316056013212	putative CheW interface [polypeptide binding]; other site
316056013213	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056013214	dimer interface [polypeptide binding]; other site
316056013215	putative CheW interface [polypeptide binding]; other site
316056013216	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
316056013217	Chemotaxis phosphatase CheX; Region: CheX; cl15816
316056013218	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
316056013219	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
316056013220	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056013221	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056013222	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
316056013223	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
316056013224	DNA-binding site [nucleotide binding]; DNA binding site
316056013225	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
316056013226	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056013227	homodimer interface [polypeptide binding]; other site
316056013228	catalytic residue [active]
316056013229	EamA-like transporter family; Region: EamA; pfam00892
316056013230	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
316056013231	EamA-like transporter family; Region: EamA; pfam00892
316056013232	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
316056013233	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
316056013234	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
316056013235	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
316056013236	Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891
316056013237	putative hydrophobic ligand binding site [chemical binding]; other site
316056013238	CLM binding site; other site
316056013239	L1 loop; other site
316056013240	DNA binding site [nucleotide binding]
316056013241	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
316056013242	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
316056013243	generic binding surface II; other site
316056013244	generic binding surface I; other site
316056013245	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
316056013246	Transposase; Region: DEDD_Tnp_IS110; pfam01548
316056013247	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
316056013248	Glucokinase; Region: Glucokinase; pfam02685
316056013249	glucokinase, proteobacterial type; Region: glk; TIGR00749
316056013250	PAS fold; Region: PAS_7; pfam12860
316056013251	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056013252	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056013253	metal binding site [ion binding]; metal-binding site
316056013254	active site
316056013255	I-site; other site
316056013256	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056013257	CHASE3 domain; Region: CHASE3; pfam05227
316056013258	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056013259	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056013260	dimer interface [polypeptide binding]; other site
316056013261	phosphorylation site [posttranslational modification]
316056013262	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056013263	ATP binding site [chemical binding]; other site
316056013264	G-X-G motif; other site
316056013265	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
316056013266	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
316056013267	MOFRL family; Region: MOFRL; pfam05161
316056013268	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
316056013269	tartrate dehydrogenase; Region: TTC; TIGR02089
316056013270	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056013271	D-galactonate transporter; Region: 2A0114; TIGR00893
316056013272	putative substrate translocation pore; other site
316056013273	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
316056013274	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056013275	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
316056013276	dimerization interface [polypeptide binding]; other site
316056013277	substrate binding pocket [chemical binding]; other site
316056013278	hypothetical protein; Provisional; Region: PRK11770
316056013279	Domain of unknown function (DUF307); Region: DUF307; pfam03733
316056013280	Domain of unknown function (DUF307); Region: DUF307; pfam03733
316056013281	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
316056013282	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
316056013283	putative ligand binding site [chemical binding]; other site
316056013284	putative NAD binding site [chemical binding]; other site
316056013285	catalytic site [active]
316056013286	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
316056013287	Protein export membrane protein; Region: SecD_SecF; cl14618
316056013288	Protein export membrane protein; Region: SecD_SecF; cl14618
316056013289	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056013290	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
316056013291	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056013292	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
316056013293	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316056013294	catalytic loop [active]
316056013295	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
316056013296	iron binding site [ion binding]; other site
316056013297	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
316056013298	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
316056013299	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
316056013300	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
316056013301	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
316056013302	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
316056013303	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
316056013304	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
316056013305	S-adenosylmethionine binding site [chemical binding]; other site
316056013306	Major Facilitator Superfamily; Region: MFS_1; pfam07690
316056013307	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056013308	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
316056013309	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
316056013310	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
316056013311	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
316056013312	catalytic loop [active]
316056013313	iron binding site [ion binding]; other site
316056013314	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
316056013315	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
316056013316	[4Fe-4S] binding site [ion binding]; other site
316056013317	molybdopterin cofactor binding site; other site
316056013318	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
316056013319	molybdopterin cofactor binding site; other site
316056013320	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
316056013321	putative dimer interface [polypeptide binding]; other site
316056013322	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
316056013323	SLBB domain; Region: SLBB; pfam10531
316056013324	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
316056013325	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
316056013326	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
316056013327	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056013328	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056013329	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
316056013330	dimerization interface [polypeptide binding]; other site
316056013331	CHAD domain; Region: CHAD; pfam05235
316056013332	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
316056013333	active site
316056013334	catalytic triad [active]
316056013335	oxyanion hole [active]
316056013336	Autotransporter beta-domain; Region: Autotransporter; smart00869
316056013337	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056013338	dimerization interface [polypeptide binding]; other site
316056013339	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056013340	dimer interface [polypeptide binding]; other site
316056013341	phosphorylation site [posttranslational modification]
316056013342	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056013343	ATP binding site [chemical binding]; other site
316056013344	Mg2+ binding site [ion binding]; other site
316056013345	G-X-G motif; other site
316056013346	osmolarity response regulator; Provisional; Region: ompR; PRK09468
316056013347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056013348	active site
316056013349	phosphorylation site [posttranslational modification]
316056013350	intermolecular recognition site; other site
316056013351	dimerization interface [polypeptide binding]; other site
316056013352	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056013353	DNA binding site [nucleotide binding]
316056013354	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
316056013355	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
316056013356	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
316056013357	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056013358	YtkA-like; Region: YtkA; pfam13115
316056013359	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056013360	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056013361	dimer interface [polypeptide binding]; other site
316056013362	putative CheW interface [polypeptide binding]; other site
316056013363	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
316056013364	PAS fold; Region: PAS_3; pfam08447
316056013365	putative active site [active]
316056013366	heme pocket [chemical binding]; other site
316056013367	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316056013368	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
316056013369	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
316056013370	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316056013371	Walker A/P-loop; other site
316056013372	ATP binding site [chemical binding]; other site
316056013373	Q-loop/lid; other site
316056013374	ABC transporter signature motif; other site
316056013375	Walker B; other site
316056013376	D-loop; other site
316056013377	H-loop/switch region; other site
316056013378	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
316056013379	Walker A/P-loop; other site
316056013380	ATP binding site [chemical binding]; other site
316056013381	Q-loop/lid; other site
316056013382	ABC transporter signature motif; other site
316056013383	Walker B; other site
316056013384	D-loop; other site
316056013385	H-loop/switch region; other site
316056013386	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
316056013387	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
316056013388	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
316056013389	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056013390	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056013391	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056013392	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056013393	dimer interface [polypeptide binding]; other site
316056013394	putative CheW interface [polypeptide binding]; other site
316056013395	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
316056013396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056013397	active site
316056013398	phosphorylation site [posttranslational modification]
316056013399	intermolecular recognition site; other site
316056013400	dimerization interface [polypeptide binding]; other site
316056013401	CheB methylesterase; Region: CheB_methylest; pfam01339
316056013402	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
316056013403	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
316056013404	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
316056013405	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
316056013406	putative CheA interaction surface; other site
316056013407	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056013408	dimerization interface [polypeptide binding]; other site
316056013409	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056013410	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056013411	dimer interface [polypeptide binding]; other site
316056013412	putative CheW interface [polypeptide binding]; other site
316056013413	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056013414	dimerization interface [polypeptide binding]; other site
316056013415	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056013416	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056013417	dimer interface [polypeptide binding]; other site
316056013418	putative CheW interface [polypeptide binding]; other site
316056013419	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
316056013420	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056013421	dimerization interface [polypeptide binding]; other site
316056013422	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056013423	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056013424	dimer interface [polypeptide binding]; other site
316056013425	putative CheW interface [polypeptide binding]; other site
316056013426	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
316056013427	dimerization interface [polypeptide binding]; other site
316056013428	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056013429	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056013430	dimer interface [polypeptide binding]; other site
316056013431	putative CheW interface [polypeptide binding]; other site
316056013432	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
316056013433	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
316056013434	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
316056013435	putative binding surface; other site
316056013436	active site
316056013437	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
316056013438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056013439	ATP binding site [chemical binding]; other site
316056013440	Mg2+ binding site [ion binding]; other site
316056013441	G-X-G motif; other site
316056013442	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
316056013443	Response regulator receiver domain; Region: Response_reg; pfam00072
316056013444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056013445	active site
316056013446	phosphorylation site [posttranslational modification]
316056013447	intermolecular recognition site; other site
316056013448	dimerization interface [polypeptide binding]; other site
316056013449	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
316056013450	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
316056013451	putative active site pocket [active]
316056013452	dimerization interface [polypeptide binding]; other site
316056013453	putative catalytic residue [active]
316056013454	Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; pfam09582
316056013455	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
316056013456	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
316056013457	Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; pfam03139
316056013458	nitrogenase iron-iron protein, alpha chain; Region: ANFD; TIGR01861
316056013459	Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of,  the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977
316056013460	nitrogenase iron protein; Region: nifH; TIGR01287
316056013461	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
316056013462	Nucleotide-binding sites [chemical binding]; other site
316056013463	Switch I region of nucleotide binding site; other site
316056013464	Fe4S4 binding sites [ion binding]; other site
316056013465	Switch II region of nucleotide binding site; other site
316056013466	HlyD family secretion protein; Region: HlyD_3; pfam13437
316056013467	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
316056013468	Caspase domain; Region: Peptidase_C14; pfam00656
316056013469	Staphylococcal nuclease homologues; Region: SNc; smart00318
316056013470	Catalytic site; other site
316056013471	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
316056013472	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
316056013473	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316056013474	catalytic residue [active]
316056013475	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
316056013476	heat shock protein HtpX; Provisional; Region: PRK01345
316056013477	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
316056013478	Cytochrome P450; Region: p450; cl12078
316056013479	cyclase homology domain; Region: CHD; cd07302
316056013480	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
316056013481	nucleotidyl binding site; other site
316056013482	metal binding site [ion binding]; metal-binding site
316056013483	dimer interface [polypeptide binding]; other site
316056013484	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
316056013485	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
316056013486	NAD(P) binding site [chemical binding]; other site
316056013487	active site
316056013488	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056013489	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056013490	metal binding site [ion binding]; metal-binding site
316056013491	active site
316056013492	I-site; other site
316056013493	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056013494	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
316056013495	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
316056013496	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
316056013497	active site
316056013498	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
316056013499	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
316056013500	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
316056013501	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
316056013502	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
316056013503	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
316056013504	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
316056013505	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
316056013506	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
316056013507	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
316056013508	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
316056013509	active site
316056013510	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
316056013511	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
316056013512	UbiA prenyltransferase family; Region: UbiA; pfam01040
316056013513	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
316056013514	MarR family; Region: MarR_2; cl17246
316056013515	Isochorismatase family; Region: Isochorismatase; pfam00857
316056013516	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
316056013517	catalytic triad [active]
316056013518	conserved cis-peptide bond; other site
316056013519	H+ Antiporter protein; Region: 2A0121; TIGR00900
316056013520	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
316056013521	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
316056013522	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
316056013523	motif 1; other site
316056013524	dimer interface [polypeptide binding]; other site
316056013525	active site
316056013526	motif 2; other site
316056013527	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
316056013528	motif 3; other site
316056013529	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
316056013530	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
316056013531	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
316056013532	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
316056013533	Ligand binding site; other site
316056013534	Putative Catalytic site; other site
316056013535	DXD motif; other site
316056013536	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
316056013537	putative active site [active]
316056013538	YdjC motif; other site
316056013539	Mg binding site [ion binding]; other site
316056013540	putative homodimer interface [polypeptide binding]; other site
316056013541	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
316056013542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
316056013543	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316056013544	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
316056013545	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
316056013546	oligomerisation interface [polypeptide binding]; other site
316056013547	mobile loop; other site
316056013548	roof hairpin; other site
316056013549	chaperonin GroEL; Reviewed; Region: groEL; PRK12852
316056013550	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
316056013551	ring oligomerisation interface [polypeptide binding]; other site
316056013552	ATP/Mg binding site [chemical binding]; other site
316056013553	stacking interactions; other site
316056013554	hinge regions; other site
316056013555	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
316056013556	L-lactate permease; Region: Lactate_perm; cl00701
316056013557	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
316056013558	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
316056013559	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
316056013560	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
316056013561	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
316056013562	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
316056013563	Cysteine-rich domain; Region: CCG; pfam02754
316056013564	Cysteine-rich domain; Region: CCG; pfam02754
316056013565	FAD binding domain; Region: FAD_binding_4; pfam01565
316056013566	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
316056013567	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
316056013568	FAD binding domain; Region: FAD_binding_4; pfam01565
316056013569	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
316056013570	AzlC protein; Region: AzlC; cl00570
316056013571	Protein of unknown function (DUF511); Region: DUF511; cl01114
316056013572	AAA domain; Region: AAA_31; pfam13614
316056013573	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
316056013574	P-loop; other site
316056013575	Magnesium ion binding site [ion binding]; other site
316056013576	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
316056013577	Magnesium ion binding site [ion binding]; other site
316056013578	FtsH Extracellular; Region: FtsH_ext; pfam06480
316056013579	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
316056013580	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056013581	Walker A motif; other site
316056013582	ATP binding site [chemical binding]; other site
316056013583	Walker B motif; other site
316056013584	arginine finger; other site
316056013585	Peptidase family M41; Region: Peptidase_M41; pfam01434
316056013586	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
316056013587	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
316056013588	Ligand Binding Site [chemical binding]; other site
316056013589	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
316056013590	sequence-specific DNA binding site [nucleotide binding]; other site
316056013591	salt bridge; other site
316056013592	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
316056013593	Septum formation initiator; Region: DivIC; cl17659
316056013594	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
316056013595	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
316056013596	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
316056013597	ligand binding site [chemical binding]; other site
316056013598	Autoinducer synthetase; Region: Autoind_synth; cl17404
316056013599	PAS fold; Region: PAS_7; pfam12860
316056013600	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
316056013601	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
316056013602	metal binding site [ion binding]; metal-binding site
316056013603	active site
316056013604	I-site; other site
316056013605	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
316056013606	translocation protein TolB; Provisional; Region: tolB; PRK05137
316056013607	TolB amino-terminal domain; Region: TolB_N; pfam04052
316056013608	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
316056013609	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
316056013610	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
316056013611	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
316056013612	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
316056013613	TolR protein; Region: tolR; TIGR02801
316056013614	TolQ protein; Region: tolQ; TIGR02796
316056013615	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
316056013616	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
316056013617	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
316056013618	non-specific DNA binding site [nucleotide binding]; other site
316056013619	salt bridge; other site
316056013620	sequence-specific DNA binding site [nucleotide binding]; other site
316056013621	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
316056013622	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
316056013623	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
316056013624	WHG domain; Region: WHG; pfam13305
316056013625	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
316056013626	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
316056013627	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056013628	putative substrate translocation pore; other site
316056013629	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
316056013630	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
316056013631	dimer interface [polypeptide binding]; other site
316056013632	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
316056013633	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
316056013634	ligand binding site [chemical binding]; other site
316056013635	flexible hinge region; other site
316056013636	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
316056013637	Cell division protein ZapA; Region: ZapA; pfam05164
316056013638	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
316056013639	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
316056013640	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
316056013641	TPP-binding site [chemical binding]; other site
316056013642	dimer interface [polypeptide binding]; other site
316056013643	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
316056013644	PYR/PP interface [polypeptide binding]; other site
316056013645	dimer interface [polypeptide binding]; other site
316056013646	TPP binding site [chemical binding]; other site
316056013647	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
316056013648	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
316056013649	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
316056013650	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
316056013651	Phosphoglycerate kinase; Region: PGK; pfam00162
316056013652	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
316056013653	substrate binding site [chemical binding]; other site
316056013654	hinge regions; other site
316056013655	ADP binding site [chemical binding]; other site
316056013656	catalytic site [active]
316056013657	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
316056013658	PemK-like protein; Region: PemK; pfam02452
316056013659	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
316056013660	active site
316056013661	intersubunit interface [polypeptide binding]; other site
316056013662	catalytic residue [active]
316056013663	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
316056013664	thiamine phosphate binding site [chemical binding]; other site
316056013665	active site
316056013666	pyrophosphate binding site [ion binding]; other site
316056013667	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
316056013668	Sel1-like repeats; Region: SEL1; smart00671
316056013669	Sel1-like repeats; Region: SEL1; smart00671
316056013670	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
316056013671	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
316056013672	active site
316056013673	dimerization interface [polypeptide binding]; other site
316056013674	putative protease; Provisional; Region: PRK15447
316056013675	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
316056013676	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
316056013677	Peptidase family U32; Region: Peptidase_U32; pfam01136
316056013678	SCP-2 sterol transfer family; Region: SCP2; cl01225
316056013679	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
316056013680	Flavoprotein; Region: Flavoprotein; pfam02441
316056013681	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
316056013682	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
316056013683	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
316056013684	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
316056013685	Catalytic site [active]
316056013686	PilZ domain; Region: PilZ; cl01260
316056013687	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
316056013688	protease TldD; Provisional; Region: tldD; PRK10735
316056013689	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
316056013690	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
316056013691	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
316056013692	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
316056013693	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
316056013694	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
316056013695	Subunit I/III interface [polypeptide binding]; other site
316056013696	D-pathway; other site
316056013697	Subunit I/VIIc interface [polypeptide binding]; other site
316056013698	Subunit I/IV interface [polypeptide binding]; other site
316056013699	Subunit I/II interface [polypeptide binding]; other site
316056013700	Low-spin heme (heme a) binding site [chemical binding]; other site
316056013701	Subunit I/VIIa interface [polypeptide binding]; other site
316056013702	Subunit I/VIa interface [polypeptide binding]; other site
316056013703	Dimer interface; other site
316056013704	Putative water exit pathway; other site
316056013705	Binuclear center (heme a3/CuB) [ion binding]; other site
316056013706	K-pathway; other site
316056013707	Subunit I/Vb interface [polypeptide binding]; other site
316056013708	Putative proton exit pathway; other site
316056013709	Subunit I/VIb interface; other site
316056013710	Subunit I/VIc interface [polypeptide binding]; other site
316056013711	Electron transfer pathway; other site
316056013712	Subunit I/VIIIb interface [polypeptide binding]; other site
316056013713	Subunit I/VIIb interface [polypeptide binding]; other site
316056013714	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
316056013715	UbiA prenyltransferase family; Region: UbiA; pfam01040
316056013716	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
316056013717	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
316056013718	Subunit III/VIIa interface [polypeptide binding]; other site
316056013719	Phospholipid binding site [chemical binding]; other site
316056013720	Subunit I/III interface [polypeptide binding]; other site
316056013721	Subunit III/VIb interface [polypeptide binding]; other site
316056013722	Subunit III/VIa interface; other site
316056013723	Subunit III/Vb interface [polypeptide binding]; other site
316056013724	Protein of unknown function (DUF983); Region: DUF983; cl02211
316056013725	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
316056013726	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
316056013727	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
316056013728	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056013729	catalytic residue [active]
316056013730	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
316056013731	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
316056013732	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
316056013733	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
316056013734	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
316056013735	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
316056013736	active site
316056013737	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
316056013738	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
316056013739	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
316056013740	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056013741	Walker A motif; other site
316056013742	ATP binding site [chemical binding]; other site
316056013743	Walker B motif; other site
316056013744	arginine finger; other site
316056013745	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
316056013746	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
316056013747	active site
316056013748	catalytic motif [active]
316056013749	Zn binding site [ion binding]; other site
316056013750	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
316056013751	RuvA N terminal domain; Region: RuvA_N; pfam01330
316056013752	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
316056013753	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
316056013754	active site
316056013755	putative DNA-binding cleft [nucleotide binding]; other site
316056013756	dimer interface [polypeptide binding]; other site
316056013757	hypothetical protein; Validated; Region: PRK00110
316056013758	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
316056013759	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056013760	dimer interface [polypeptide binding]; other site
316056013761	putative CheW interface [polypeptide binding]; other site
316056013762	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
316056013763	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056013764	dimer interface [polypeptide binding]; other site
316056013765	putative CheW interface [polypeptide binding]; other site
316056013766	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
316056013767	Radical SAM superfamily; Region: Radical_SAM; pfam04055
316056013768	FeS/SAM binding site; other site
316056013769	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
316056013770	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
316056013771	putative active site [active]
316056013772	metal binding site [ion binding]; metal-binding site
316056013773	homodimer binding site [polypeptide binding]; other site
316056013774	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
316056013775	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
316056013776	F0F1 ATP synthase subunit B; Provisional; Region: PRK14475
316056013777	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
316056013778	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
316056013779	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
316056013780	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
316056013781	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
316056013782	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
316056013783	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
316056013784	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
316056013785	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
316056013786	putative catalytic residue [active]
316056013787	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
316056013788	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
316056013789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
316056013790	putative substrate translocation pore; other site
316056013791	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
316056013792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056013793	active site
316056013794	phosphorylation site [posttranslational modification]
316056013795	intermolecular recognition site; other site
316056013796	dimerization interface [polypeptide binding]; other site
316056013797	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
316056013798	DNA binding residues [nucleotide binding]
316056013799	dimerization interface [polypeptide binding]; other site
316056013800	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
316056013801	Na binding site [ion binding]; other site
316056013802	PAS fold; Region: PAS_7; pfam12860
316056013803	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056013804	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056013805	dimer interface [polypeptide binding]; other site
316056013806	phosphorylation site [posttranslational modification]
316056013807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056013808	ATP binding site [chemical binding]; other site
316056013809	Mg2+ binding site [ion binding]; other site
316056013810	G-X-G motif; other site
316056013811	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
316056013812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056013813	active site
316056013814	phosphorylation site [posttranslational modification]
316056013815	intermolecular recognition site; other site
316056013816	dimerization interface [polypeptide binding]; other site
316056013817	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
316056013818	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
316056013819	substrate-cofactor binding pocket; other site
316056013820	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056013821	catalytic residue [active]
316056013822	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
316056013823	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
316056013824	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
316056013825	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
316056013826	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
316056013827	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
316056013828	ABC-ATPase subunit  interface; other site
316056013829	dimer interface [polypeptide binding]; other site
316056013830	putative PBP binding regions; other site
316056013831	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
316056013832	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
316056013833	metal binding site [ion binding]; metal-binding site
316056013834	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
316056013835	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
316056013836	P-loop, Walker A motif; other site
316056013837	Base recognition motif; other site
316056013838	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
316056013839	FOG: WD40 repeat [General function prediction only]; Region: COG2319
316056013840	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
316056013841	structural tetrad; other site
316056013842	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
316056013843	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
316056013844	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
316056013845	homotrimer interaction site [polypeptide binding]; other site
316056013846	putative active site [active]
316056013847	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
316056013848	Coenzyme A binding pocket [chemical binding]; other site
316056013849	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
316056013850	dimer interface [polypeptide binding]; other site
316056013851	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
316056013852	active site
316056013853	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
316056013854	catalytic residues [active]
316056013855	substrate binding site [chemical binding]; other site
316056013856	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
316056013857	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
316056013858	active site
316056013859	Zn binding site [ion binding]; other site
316056013860	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
316056013861	High-affinity nickel-transport protein; Region: NicO; cl00964
316056013862	High-affinity nickel-transport protein; Region: NicO; cl00964
316056013863	ferrochelatase; Reviewed; Region: hemH; PRK00035
316056013864	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
316056013865	C-terminal domain interface [polypeptide binding]; other site
316056013866	active site
316056013867	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
316056013868	active site
316056013869	N-terminal domain interface [polypeptide binding]; other site
316056013870	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
316056013871	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
316056013872	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
316056013873	recombination protein RecR; Reviewed; Region: recR; PRK00076
316056013874	RecR protein; Region: RecR; pfam02132
316056013875	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
316056013876	tetramer interface [polypeptide binding]; other site
316056013877	putative active site [active]
316056013878	putative metal-binding site [ion binding]; other site
316056013879	hypothetical protein; Validated; Region: PRK00153
316056013880	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
316056013881	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
316056013882	Walker A motif; other site
316056013883	ATP binding site [chemical binding]; other site
316056013884	Walker B motif; other site
316056013885	arginine finger; other site
316056013886	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
316056013887	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
316056013888	HIT domain; Region: HIT; pfam01230
316056013889	nucleotide binding site/active site [active]
316056013890	HIT family signature motif; other site
316056013891	catalytic residue [active]
316056013892	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
316056013893	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
316056013894	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
316056013895	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
316056013896	putative NADH binding site [chemical binding]; other site
316056013897	putative active site [active]
316056013898	nudix motif; other site
316056013899	putative metal binding site [ion binding]; other site
316056013900	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
316056013901	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
316056013902	substrate binding site [chemical binding]; other site
316056013903	ATP binding site [chemical binding]; other site
316056013904	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
316056013905	catalytic motif [active]
316056013906	Catalytic residue [active]
316056013907	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
316056013908	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
316056013909	putative Mg++ binding site [ion binding]; other site
316056013910	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
316056013911	nucleotide binding region [chemical binding]; other site
316056013912	ATP-binding site [chemical binding]; other site
316056013913	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
316056013914	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
316056013915	Predicted membrane protein [Function unknown]; Region: COG4763
316056013916	Acyltransferase family; Region: Acyl_transf_3; pfam01757
316056013917	5'-3' exonuclease; Region: 53EXOc; smart00475
316056013918	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
316056013919	active site
316056013920	metal binding site 1 [ion binding]; metal-binding site
316056013921	putative 5' ssDNA interaction site; other site
316056013922	metal binding site 3; metal-binding site
316056013923	metal binding site 2 [ion binding]; metal-binding site
316056013924	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
316056013925	putative DNA binding site [nucleotide binding]; other site
316056013926	putative metal binding site [ion binding]; other site
316056013927	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
316056013928	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
316056013929	active site
316056013930	catalytic site [active]
316056013931	substrate binding site [chemical binding]; other site
316056013932	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
316056013933	active site
316056013934	DNA binding site [nucleotide binding]
316056013935	catalytic site [active]
316056013936	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
316056013937	active site
316056013938	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
316056013939	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
316056013940	homodimer interface [polypeptide binding]; other site
316056013941	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
316056013942	active site pocket [active]
316056013943	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
316056013944	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
316056013945	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
316056013946	putative active site pocket [active]
316056013947	dimerization interface [polypeptide binding]; other site
316056013948	putative catalytic residue [active]
316056013949	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
316056013950	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
316056013951	putative acyl-acceptor binding pocket; other site
316056013952	Uncharacterized conserved protein [Function unknown]; Region: COG1434
316056013953	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
316056013954	putative active site [active]
316056013955	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
316056013956	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
316056013957	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
316056013958	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
316056013959	Walker A/P-loop; other site
316056013960	ATP binding site [chemical binding]; other site
316056013961	Q-loop/lid; other site
316056013962	ABC transporter signature motif; other site
316056013963	Walker B; other site
316056013964	D-loop; other site
316056013965	H-loop/switch region; other site
316056013966	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
316056013967	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
316056013968	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
316056013969	Response regulator receiver domain; Region: Response_reg; pfam00072
316056013970	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056013971	active site
316056013972	phosphorylation site [posttranslational modification]
316056013973	intermolecular recognition site; other site
316056013974	dimerization interface [polypeptide binding]; other site
316056013975	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
316056013976	tyrosine decarboxylase; Region: PLN02880
316056013977	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
316056013978	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056013979	catalytic residue [active]
316056013980	TIGR02302 family protein; Region: aProt_lowcomp
316056013981	Protein of unknown function (DUF964); Region: DUF964; cl01483
316056013982	diaminopimelate decarboxylase; Region: lysA; TIGR01048
316056013983	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
316056013984	active site
316056013985	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
316056013986	substrate binding site [chemical binding]; other site
316056013987	catalytic residues [active]
316056013988	dimer interface [polypeptide binding]; other site
316056013989	argininosuccinate lyase; Provisional; Region: PRK00855
316056013990	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
316056013991	active sites [active]
316056013992	tetramer interface [polypeptide binding]; other site
316056013993	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
316056013994	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
316056013995	catalytic residues [active]
316056013996	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
316056013997	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
316056013998	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
316056013999	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
316056014000	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
316056014001	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
316056014002	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
316056014003	Ligand binding site [chemical binding]; other site
316056014004	Electron transfer flavoprotein domain; Region: ETF; pfam01012
316056014005	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
316056014006	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
316056014007	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
316056014008	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056014009	dimer interface [polypeptide binding]; other site
316056014010	phosphorylation site [posttranslational modification]
316056014011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056014012	ATP binding site [chemical binding]; other site
316056014013	Mg2+ binding site [ion binding]; other site
316056014014	G-X-G motif; other site
316056014015	Response regulator receiver domain; Region: Response_reg; pfam00072
316056014016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056014017	active site
316056014018	phosphorylation site [posttranslational modification]
316056014019	intermolecular recognition site; other site
316056014020	dimerization interface [polypeptide binding]; other site
316056014021	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
316056014022	active site
316056014023	HIGH motif; other site
316056014024	nucleotide binding site [chemical binding]; other site
316056014025	active site
316056014026	KMSKS motif; other site
316056014027	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
316056014028	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
316056014029	minor groove reading motif; other site
316056014030	helix-hairpin-helix signature motif; other site
316056014031	active site
316056014032	Uncharacterized conserved protein [Function unknown]; Region: COG4748
316056014033	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
316056014034	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
316056014035	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
316056014036	putative active site [active]
316056014037	PAS fold; Region: PAS_4; pfam08448
316056014038	PAS fold; Region: PAS_4; pfam08448
316056014039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056014040	ATP binding site [chemical binding]; other site
316056014041	Mg2+ binding site [ion binding]; other site
316056014042	G-X-G motif; other site
316056014043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056014044	active site
316056014045	phosphorylation site [posttranslational modification]
316056014046	intermolecular recognition site; other site
316056014047	dimerization interface [polypeptide binding]; other site
316056014048	PRC-barrel domain; Region: PRC; pfam05239
316056014049	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
316056014050	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
316056014051	active site
316056014052	catalytic site [active]
316056014053	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
316056014054	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
316056014055	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
316056014056	putative NAD(P) binding site [chemical binding]; other site
316056014057	putative substrate binding site [chemical binding]; other site
316056014058	catalytic Zn binding site [ion binding]; other site
316056014059	structural Zn binding site [ion binding]; other site
316056014060	dimer interface [polypeptide binding]; other site
316056014061	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
316056014062	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
316056014063	active site
316056014064	catalytic tetrad [active]
316056014065	Transcriptional regulator [Transcription]; Region: LysR; COG0583
316056014066	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
316056014067	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
316056014068	putative effector binding pocket; other site
316056014069	putative dimerization interface [polypeptide binding]; other site
316056014070	AAA ATPase domain; Region: AAA_16; pfam13191
316056014071	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
316056014072	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
316056014073	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
316056014074	DNA binding site [nucleotide binding]
316056014075	active site
316056014076	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
316056014077	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
316056014078	active site
316056014079	NTP binding site [chemical binding]; other site
316056014080	metal binding triad [ion binding]; metal-binding site
316056014081	antibiotic binding site [chemical binding]; other site
316056014082	HEPN domain; Region: HEPN; pfam05168
316056014083	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
316056014084	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
316056014085	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
316056014086	trimer interface [polypeptide binding]; other site
316056014087	active site
316056014088	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
316056014089	trimer interface [polypeptide binding]; other site
316056014090	active site
316056014091	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
316056014092	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
316056014093	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
316056014094	catalytic residue [active]
316056014095	sensor protein QseC; Provisional; Region: PRK10337
316056014096	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056014097	dimer interface [polypeptide binding]; other site
316056014098	phosphorylation site [posttranslational modification]
316056014099	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056014100	ATP binding site [chemical binding]; other site
316056014101	Mg2+ binding site [ion binding]; other site
316056014102	G-X-G motif; other site
316056014103	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316056014104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056014105	active site
316056014106	phosphorylation site [posttranslational modification]
316056014107	intermolecular recognition site; other site
316056014108	dimerization interface [polypeptide binding]; other site
316056014109	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056014110	DNA binding site [nucleotide binding]
316056014111	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
316056014112	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
316056014113	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
316056014114	DsbD alpha interface [polypeptide binding]; other site
316056014115	catalytic residues [active]
316056014116	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
316056014117	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
316056014118	catalytic residues [active]
316056014119	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
316056014120	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
316056014121	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
316056014122	active site
316056014123	oxyanion hole [active]
316056014124	catalytic triad [active]
316056014125	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
316056014126	oxyanion hole [active]
316056014127	OpgC protein; Region: OpgC_C; pfam10129
316056014128	Acyltransferase family; Region: Acyl_transf_3; pfam01757
316056014129	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
316056014130	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
316056014131	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
316056014132	dimerization interface [polypeptide binding]; other site
316056014133	domain crossover interface; other site
316056014134	redox-dependent activation switch; other site
316056014135	ornithine carbamoyltransferase; Provisional; Region: PRK00779
316056014136	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
316056014137	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
316056014138	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
316056014139	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
316056014140	inhibitor-cofactor binding pocket; inhibition site
316056014141	pyridoxal 5'-phosphate binding site [chemical binding]; other site
316056014142	catalytic residue [active]
316056014143	GcrA cell cycle regulator; Region: GcrA; pfam07750
316056014144	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
316056014145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056014146	active site
316056014147	phosphorylation site [posttranslational modification]
316056014148	intermolecular recognition site; other site
316056014149	dimerization interface [polypeptide binding]; other site
316056014150	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056014151	DNA binding site [nucleotide binding]
316056014152	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
316056014153	PhoU domain; Region: PhoU; pfam01895
316056014154	PhoU domain; Region: PhoU; pfam01895
316056014155	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
316056014156	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
316056014157	Walker A/P-loop; other site
316056014158	ATP binding site [chemical binding]; other site
316056014159	Q-loop/lid; other site
316056014160	ABC transporter signature motif; other site
316056014161	Walker B; other site
316056014162	D-loop; other site
316056014163	H-loop/switch region; other site
316056014164	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
316056014165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056014166	dimer interface [polypeptide binding]; other site
316056014167	conserved gate region; other site
316056014168	putative PBP binding loops; other site
316056014169	ABC-ATPase subunit interface; other site
316056014170	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
316056014171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
316056014172	dimer interface [polypeptide binding]; other site
316056014173	conserved gate region; other site
316056014174	putative PBP binding loops; other site
316056014175	ABC-ATPase subunit interface; other site
316056014176	PBP superfamily domain; Region: PBP_like_2; cl17296
316056014177	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
316056014178	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
316056014179	dimer interface [polypeptide binding]; other site
316056014180	phosphorylation site [posttranslational modification]
316056014181	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056014182	ATP binding site [chemical binding]; other site
316056014183	Mg2+ binding site [ion binding]; other site
316056014184	G-X-G motif; other site
316056014185	Predicted integral membrane protein [Function unknown]; Region: COG0392
316056014186	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
316056014187	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
316056014188	ligand binding site [chemical binding]; other site
316056014189	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
316056014190	putative active site [active]
316056014191	putative metal binding site [ion binding]; other site
316056014192	heat shock protein 90; Provisional; Region: PRK05218
316056014193	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056014194	ATP binding site [chemical binding]; other site
316056014195	Mg2+ binding site [ion binding]; other site
316056014196	G-X-G motif; other site
316056014197	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
316056014198	dimer interface [polypeptide binding]; other site
316056014199	putative CheW interface [polypeptide binding]; other site
316056014200	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
316056014201	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
316056014202	ATP binding site [chemical binding]; other site
316056014203	Mg2+ binding site [ion binding]; other site
316056014204	G-X-G motif; other site
316056014205	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
316056014206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
316056014207	active site
316056014208	phosphorylation site [posttranslational modification]
316056014209	intermolecular recognition site; other site
316056014210	dimerization interface [polypeptide binding]; other site
316056014211	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
316056014212	DNA binding site [nucleotide binding]
316056014213	Predicted membrane protein [Function unknown]; Region: COG3212
316056014214	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
316056014215	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
316056014216	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
316056014217	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
316056014218	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
316056014219	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
316056014220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
316056014221	active site
316056014222	phosphorylation site [posttranslational modification]
316056014223	intermolecular recognition site; other site
316056014224	dimerization interface [polypeptide binding]; other site
316056014225	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
316056014226	Zn2+ binding site [ion binding]; other site
316056014227	Mg2+ binding site [ion binding]; other site
316056014228	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
316056014229	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
316056014230	SLBB domain; Region: SLBB; pfam10531
316056014231	methionine sulfoxide reductase A; Provisional; Region: PRK00058
316056014232	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239