-- dump date   	20140620_032624
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
258594000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
258594000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
258594000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594000004	Walker A motif; other site
258594000005	ATP binding site [chemical binding]; other site
258594000006	Walker B motif; other site
258594000007	arginine finger; other site
258594000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
258594000009	DnaA box-binding interface [nucleotide binding]; other site
258594000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
258594000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
258594000012	putative DNA binding surface [nucleotide binding]; other site
258594000013	dimer interface [polypeptide binding]; other site
258594000014	beta-clamp/clamp loader binding surface; other site
258594000015	beta-clamp/translesion DNA polymerase binding surface; other site
258594000016	recombination protein F; Reviewed; Region: recF; PRK00064
258594000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594000018	Walker A/P-loop; other site
258594000019	ATP binding site [chemical binding]; other site
258594000020	Q-loop/lid; other site
258594000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594000022	ABC transporter signature motif; other site
258594000023	Walker B; other site
258594000024	D-loop; other site
258594000025	H-loop/switch region; other site
258594000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
258594000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594000028	Mg2+ binding site [ion binding]; other site
258594000029	G-X-G motif; other site
258594000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
258594000031	anchoring element; other site
258594000032	dimer interface [polypeptide binding]; other site
258594000033	ATP binding site [chemical binding]; other site
258594000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
258594000035	active site
258594000036	putative metal-binding site [ion binding]; other site
258594000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
258594000038	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
258594000039	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
258594000040	dimer interface [polypeptide binding]; other site
258594000041	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
258594000042	active site
258594000043	Fe binding site [ion binding]; other site
258594000044	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
258594000045	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594000046	putative DNA binding site [nucleotide binding]; other site
258594000047	putative Zn2+ binding site [ion binding]; other site
258594000048	AsnC family; Region: AsnC_trans_reg; pfam01037
258594000049	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
258594000050	PAS domain; Region: PAS_9; pfam13426
258594000051	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
258594000052	HWE histidine kinase; Region: HWE_HK; pfam07536
258594000053	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
258594000054	tetramer interface [polypeptide binding]; other site
258594000055	dimer interface [polypeptide binding]; other site
258594000056	circadian clock protein KaiC; Reviewed; Region: PRK09302
258594000057	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
258594000058	Walker A motif; other site
258594000059	ATP binding site [chemical binding]; other site
258594000060	Walker B motif; other site
258594000061	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
258594000062	Walker A motif; other site
258594000063	ATP binding site [chemical binding]; other site
258594000064	Walker B motif; other site
258594000065	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
258594000066	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594000067	putative DNA binding site [nucleotide binding]; other site
258594000068	putative Zn2+ binding site [ion binding]; other site
258594000069	AsnC family; Region: AsnC_trans_reg; pfam01037
258594000070	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
258594000071	1 probable transmembrane helix predicted byTMHMM2.0
258594000072	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
258594000073	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
258594000074	metal-binding site [ion binding]
258594000075	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
258594000076	Soluble P-type ATPase [General function prediction only]; Region: COG4087
258594000077	8 probable transmembrane helices predicted byTMHMM2.0
258594000078	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
258594000079	Region: FixH; pfam05751
258594000080	1 probable transmembrane helix predicted byTMHMM2.0
258594000081	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
258594000082	4Fe-4S binding domain; Region: Fer4_5; pfam12801
258594000083	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
258594000084	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
258594000085	5 probable transmembrane helices predicted byTMHMM2.0
258594000086	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
258594000087	Cytochrome c; Region: Cytochrom_C; pfam00034
258594000088	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
258594000089	1 probable transmembrane helix predicted byTMHMM2.0
258594000090	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
258594000091	1 probable transmembrane helix predicted byTMHMM2.0
258594000092	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
258594000093	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
258594000094	1 probable transmembrane helix predicted byTMHMM2.0
258594000095	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
258594000096	Low-spin heme binding site [chemical binding]; other site
258594000097	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
258594000098	Putative water exit pathway; other site
258594000099	Binuclear center (active site) [active]
258594000100	Putative proton exit pathway; other site
258594000101	14 probable transmembrane helices predicted byTMHMM2.0
258594000102	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
258594000103	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
258594000104	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
258594000105	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
258594000106	classical (c) SDR, subgroup  10; Region: SDR_c10; cd05373
258594000107	putative NAD(P) binding site [chemical binding]; other site
258594000108	active site
258594000109	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
258594000110	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
258594000111	putative catalytic residue [active]
258594000112	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
258594000113	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
258594000114	putative C-terminal domain interface [polypeptide binding]; other site
258594000115	putative GSH binding site (G-site) [chemical binding]; other site
258594000116	putative dimer interface [polypeptide binding]; other site
258594000117	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
258594000118	putative N-terminal domain interface [polypeptide binding]; other site
258594000119	putative dimer interface [polypeptide binding]; other site
258594000120	putative substrate binding pocket (H-site) [chemical binding]; other site
258594000121	short chain dehydrogenase; Provisional; Region: PRK08278
258594000122	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
258594000123	NAD(P) binding site [chemical binding]; other site
258594000124	homodimer interface [polypeptide binding]; other site
258594000125	active site
258594000126	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
258594000127	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
258594000128	1 probable transmembrane helix predicted byTMHMM2.0
258594000129	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
258594000130	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594000131	11 probable transmembrane helices predicted byTMHMM2.0
258594000132	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
258594000133	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
258594000134	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
258594000135	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
258594000136	purine monophosphate binding site [chemical binding]; other site
258594000137	dimer interface [polypeptide binding]; other site
258594000138	putative catalytic residues [active]
258594000139	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
258594000140	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
258594000141	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
258594000142	NusB family; Region: NusB; pfam01029
258594000143	putative RNA binding site [nucleotide binding]; other site
258594000144	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
258594000145	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594000146	S-adenosylmethionine binding site [chemical binding]; other site
258594000147	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
258594000148	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
258594000149	1 probable transmembrane helix predicted byTMHMM2.0
258594000150	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
258594000151	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
258594000152	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
258594000153	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
258594000154	putative tRNA-binding site [nucleotide binding]; other site
258594000155	B3/4 domain; Region: B3_4; pfam03483
258594000156	tRNA synthetase B5 domain; Region: B5; smart00874
258594000157	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
258594000158	dimer interface [polypeptide binding]; other site
258594000159	motif 1; other site
258594000160	motif 3; other site
258594000161	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
258594000162	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
258594000163	putative active site [active]
258594000164	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
258594000165	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
258594000166	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
258594000167	dimer interface [polypeptide binding]; other site
258594000168	motif 1; other site
258594000169	active site
258594000170	motif 2; other site
258594000171	motif 3; other site
258594000172	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
258594000173	23S rRNA binding site [nucleotide binding]; other site
258594000174	L21 binding site [polypeptide binding]; other site
258594000175	L13 binding site [polypeptide binding]; other site
258594000176	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
258594000177	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
258594000178	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
258594000179	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
258594000180	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
258594000181	epoxyqueuosine reductase; Region: TIGR00276
258594000182	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
258594000183	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
258594000184	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
258594000185	C-terminal domain interface [polypeptide binding]; other site
258594000186	GSH binding site (G-site) [chemical binding]; other site
258594000187	dimer interface [polypeptide binding]; other site
258594000188	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
258594000189	N-terminal domain interface [polypeptide binding]; other site
258594000190	dimer interface [polypeptide binding]; other site
258594000191	substrate binding pocket (H-site) [chemical binding]; other site
258594000192	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
258594000193	7 probable transmembrane helices predicted byTMHMM2.0
258594000194	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
258594000195	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
258594000196	putative NAD(P) binding site [chemical binding]; other site
258594000197	active site
258594000198	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
258594000199	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
258594000200	catalytic site [active]
258594000201	putative active site [active]
258594000202	putative substrate binding site [chemical binding]; other site
258594000203	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
258594000204	1 probable transmembrane helix predicted byTMHMM2.0
258594000205	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
258594000206	OstA-like protein; Region: OstA; pfam03968
258594000207	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
258594000208	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
258594000209	Walker A/P-loop; other site
258594000210	ATP binding site [chemical binding]; other site
258594000211	Q-loop/lid; other site
258594000212	ABC transporter signature motif; other site
258594000213	Walker B; other site
258594000214	D-loop; other site
258594000215	H-loop/switch region; other site
258594000216	RNA polymerase factor sigma-54; Provisional; Region: PRK12469
258594000217	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
258594000218	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
258594000219	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
258594000220	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
258594000221	30S subunit binding site; other site
258594000222	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
258594000223	active site
258594000224	phosphorylation site [posttranslational modification]
258594000225	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
258594000226	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
258594000227	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
258594000228	putative dimer interface [polypeptide binding]; other site
258594000229	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
258594000230	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
258594000231	Walker A/P-loop; other site
258594000232	ATP binding site [chemical binding]; other site
258594000233	Q-loop/lid; other site
258594000234	ABC transporter signature motif; other site
258594000235	Walker B; other site
258594000236	D-loop; other site
258594000237	H-loop/switch region; other site
258594000238	TOBE domain; Region: TOBE_2; pfam08402
258594000239	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
258594000240	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594000241	dimer interface [polypeptide binding]; other site
258594000242	conserved gate region; other site
258594000243	putative PBP binding loops; other site
258594000244	ABC-ATPase subunit interface; other site
258594000245	6 probable transmembrane helices predicted byTMHMM2.0
258594000246	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594000247	putative PBP binding loops; other site
258594000248	dimer interface [polypeptide binding]; other site
258594000249	ABC-ATPase subunit interface; other site
258594000250	6 probable transmembrane helices predicted byTMHMM2.0
258594000251	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
258594000252	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
258594000253	1 probable transmembrane helix predicted byTMHMM2.0
258594000254	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
258594000255	CoA-transferase family III; Region: CoA_transf_3; pfam02515
258594000256	TIGR02300 family protein; Region: FYDLN_acid
258594000257	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
258594000258	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
258594000259	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
258594000260	hinge; other site
258594000261	active site
258594000262	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
258594000263	putative acyl-acceptor binding pocket; other site
258594000264	cytidylate kinase; Provisional; Region: cmk; PRK00023
258594000265	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
258594000266	CMP-binding site; other site
258594000267	The sites determining sugar specificity; other site
258594000268	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
258594000269	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
258594000270	RNA binding site [nucleotide binding]; other site
258594000271	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
258594000272	RNA binding site [nucleotide binding]; other site
258594000273	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
258594000274	RNA binding site [nucleotide binding]; other site
258594000275	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
258594000276	RNA binding site [nucleotide binding]; other site
258594000277	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
258594000278	RNA binding site [nucleotide binding]; other site
258594000279	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
258594000280	RNA binding site [nucleotide binding]; other site
258594000281	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
258594000282	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
258594000283	tandem repeat interface [polypeptide binding]; other site
258594000284	oligomer interface [polypeptide binding]; other site
258594000285	active site residues [active]
258594000286	1 probable transmembrane helix predicted byTMHMM2.0
258594000287	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
258594000288	IHF dimer interface [polypeptide binding]; other site
258594000289	IHF - DNA interface [nucleotide binding]; other site
258594000290	2 probable transmembrane helices predicted byTMHMM2.0
258594000291	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
258594000292	active site
258594000293	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
258594000294	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
258594000295	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594000296	catalytic residue [active]
258594000297	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
258594000298	substrate binding site [chemical binding]; other site
258594000299	active site
258594000300	catalytic residues [active]
258594000301	heterodimer interface [polypeptide binding]; other site
258594000302	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
258594000303	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
258594000304	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
258594000305	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
258594000306	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
258594000307	catalytic residues [active]
258594000308	Part of AAA domain; Region: AAA_19; pfam13245
258594000309	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
258594000310	Family description; Region: UvrD_C_2; pfam13538
258594000311	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
258594000312	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
258594000313	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
258594000314	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
258594000315	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
258594000316	Substrate binding site; other site
258594000317	metal-binding site
258594000318	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
258594000319	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
258594000320	Phosphotransferase enzyme family; Region: APH; pfam01636
258594000321	PAS fold; Region: PAS_7; pfam12860
258594000322	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
258594000323	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594000324	dimer interface [polypeptide binding]; other site
258594000325	phosphorylation site [posttranslational modification]
258594000326	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594000327	ATP binding site [chemical binding]; other site
258594000328	Mg2+ binding site [ion binding]; other site
258594000329	G-X-G motif; other site
258594000330	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
258594000331	trimer interface [polypeptide binding]; other site
258594000332	active site
258594000333	bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982
258594000334	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
258594000335	Flavoprotein; Region: Flavoprotein; pfam02441
258594000336	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
258594000337	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
258594000338	ABC1 family; Region: ABC1; cl17513
258594000339	1 probable transmembrane helix predicted byTMHMM2.0
258594000340	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
258594000341	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594000342	S-adenosylmethionine binding site [chemical binding]; other site
258594000343	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
258594000344	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
258594000345	DNA binding site [nucleotide binding]
258594000346	catalytic residue [active]
258594000347	H2TH interface [polypeptide binding]; other site
258594000348	putative catalytic residues [active]
258594000349	turnover-facilitating residue; other site
258594000350	intercalation triad [nucleotide binding]; other site
258594000351	8OG recognition residue [nucleotide binding]; other site
258594000352	putative reading head residues; other site
258594000353	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
258594000354	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
258594000355	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
258594000356	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
258594000357	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
258594000358	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
258594000359	ATP binding site [chemical binding]; other site
258594000360	substrate interface [chemical binding]; other site
258594000361	Transmembrane secretion effector; Region: MFS_3; pfam05977
258594000362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594000363	putative substrate translocation pore; other site
258594000364	10 probable transmembrane helices predicted byTMHMM2.0
258594000365	Phasin protein; Region: Phasin_2; cl11491
258594000366	2 probable transmembrane helices predicted byTMHMM2.0
258594000367	1 probable transmembrane helix predicted byTMHMM2.0
258594000368	Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977
258594000369	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594000370	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594000371	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
258594000372	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
258594000373	4 probable transmembrane helices predicted byTMHMM2.0
258594000374	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594000375	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594000376	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594000377	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
258594000378	12 probable transmembrane helices predicted byTMHMM2.0
258594000379	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
258594000380	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
258594000381	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
258594000382	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594000383	Walker A/P-loop; other site
258594000384	ATP binding site [chemical binding]; other site
258594000385	Q-loop/lid; other site
258594000386	ABC transporter signature motif; other site
258594000387	Walker B; other site
258594000388	D-loop; other site
258594000389	H-loop/switch region; other site
258594000390	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
258594000391	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
258594000392	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594000393	Walker A/P-loop; other site
258594000394	ATP binding site [chemical binding]; other site
258594000395	Q-loop/lid; other site
258594000396	ABC transporter signature motif; other site
258594000397	Walker B; other site
258594000398	D-loop; other site
258594000399	H-loop/switch region; other site
258594000400	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
258594000401	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
258594000402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594000403	dimer interface [polypeptide binding]; other site
258594000404	conserved gate region; other site
258594000405	putative PBP binding loops; other site
258594000406	ABC-ATPase subunit interface; other site
258594000407	5 probable transmembrane helices predicted byTMHMM2.0
258594000408	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
258594000409	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594000410	dimer interface [polypeptide binding]; other site
258594000411	conserved gate region; other site
258594000412	putative PBP binding loops; other site
258594000413	ABC-ATPase subunit interface; other site
258594000414	6 probable transmembrane helices predicted byTMHMM2.0
258594000415	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
258594000416	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
258594000417	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
258594000418	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
258594000419	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
258594000420	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
258594000421	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
258594000422	active site
258594000423	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
258594000424	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
258594000425	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
258594000426	DNA-binding site [nucleotide binding]; DNA binding site
258594000427	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
258594000428	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594000429	homodimer interface [polypeptide binding]; other site
258594000430	catalytic residue [active]
258594000431	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
258594000432	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594000433	putative ligand binding site [chemical binding]; other site
258594000434	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
258594000435	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
258594000436	putative NAD(P) binding site [chemical binding]; other site
258594000437	catalytic Zn binding site [ion binding]; other site
258594000438	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
258594000439	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
258594000440	PYR/PP interface [polypeptide binding]; other site
258594000441	dimer interface [polypeptide binding]; other site
258594000442	TPP binding site [chemical binding]; other site
258594000443	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
258594000444	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
258594000445	TPP-binding site; other site
258594000446	dimer interface [polypeptide binding]; other site
258594000447	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
258594000448	classical (c) SDRs; Region: SDR_c; cd05233
258594000449	NAD(P) binding site [chemical binding]; other site
258594000450	active site
258594000451	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594000452	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594000453	7 probable transmembrane helices predicted byTMHMM2.0
258594000454	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
258594000455	Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; Region: ALDH_MGR_2402; cd07108
258594000456	NAD(P) binding site [chemical binding]; other site
258594000457	catalytic residues [active]
258594000458	catalytic residues [active]
258594000459	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
258594000460	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
258594000461	2 probable transmembrane helices predicted byTMHMM2.0
258594000462	pseudogene, disrupted by an internal inversion
258594000463	pseudogene, N-terminal portion of a gene disrupted by an inversion;dTDP-D-glucose 4,6-dehydratase
258594000464	pseudogene, this segment is inverted with respect to the N- and C-terminal ends of the original gene.;possible dTDP-D-glucose-4,6-dehydratase
258594000465	pseudogene, C-terminal portion of gene disrupted by an inversion;dTDP-D-glucose 4,6-dehydratase
258594000466	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
258594000467	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
258594000468	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
258594000469	NADP binding site [chemical binding]; other site
258594000470	active site
258594000471	putative substrate binding site [chemical binding]; other site
258594000472	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
258594000473	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
258594000474	substrate binding site; other site
258594000475	tetramer interface; other site
258594000476	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
258594000477	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
258594000478	Phytochrome region; Region: PHY; pfam00360
258594000479	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
258594000480	dimer interface [polypeptide binding]; other site
258594000481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594000482	ATP binding site [chemical binding]; other site
258594000483	Mg2+ binding site [ion binding]; other site
258594000484	G-X-G motif; other site
258594000485	Ion channel; Region: Ion_trans_2; pfam07885
258594000486	TrkA-N domain; Region: TrkA_N; pfam02254
258594000487	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
258594000488	TrkA-N domain; Region: TrkA_N; pfam02254
258594000489	3 probable transmembrane helices predicted byTMHMM2.0
258594000490	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
258594000491	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
258594000492	active site
258594000493	metal binding site [ion binding]; metal-binding site
258594000494	hexamer interface [polypeptide binding]; other site
258594000495	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
258594000496	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
258594000497	active site
258594000498	metal binding site [ion binding]; metal-binding site
258594000499	hexamer interface [polypeptide binding]; other site
258594000500	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
258594000501	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
258594000502	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
258594000503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594000504	dimer interface [polypeptide binding]; other site
258594000505	conserved gate region; other site
258594000506	putative PBP binding loops; other site
258594000507	ABC-ATPase subunit interface; other site
258594000508	6 probable transmembrane helices predicted byTMHMM2.0
258594000509	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594000510	dimer interface [polypeptide binding]; other site
258594000511	conserved gate region; other site
258594000512	putative PBP binding loops; other site
258594000513	ABC-ATPase subunit interface; other site
258594000514	6 probable transmembrane helices predicted byTMHMM2.0
258594000515	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
258594000516	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594000517	Walker A/P-loop; other site
258594000518	ATP binding site [chemical binding]; other site
258594000519	Q-loop/lid; other site
258594000520	ABC transporter signature motif; other site
258594000521	Walker B; other site
258594000522	D-loop; other site
258594000523	H-loop/switch region; other site
258594000524	TOBE domain; Region: TOBE_2; pfam08402
258594000525	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
258594000526	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594000527	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
258594000528	dimerization interface [polypeptide binding]; other site
258594000529	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
258594000530	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594000531	Walker A/P-loop; other site
258594000532	ATP binding site [chemical binding]; other site
258594000533	Q-loop/lid; other site
258594000534	ABC transporter signature motif; other site
258594000535	Walker B; other site
258594000536	D-loop; other site
258594000537	H-loop/switch region; other site
258594000538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
258594000539	6 probable transmembrane helices predicted byTMHMM2.0
258594000540	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
258594000541	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
258594000542	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
258594000543	catalytic loop [active]
258594000544	iron binding site [ion binding]; other site
258594000545	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
258594000546	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
258594000547	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
258594000548	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
258594000549	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
258594000550	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
258594000551	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
258594000552	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
258594000553	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
258594000554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594000555	active site
258594000556	phosphorylation site [posttranslational modification]
258594000557	intermolecular recognition site; other site
258594000558	dimerization interface [polypeptide binding]; other site
258594000559	CheB methylesterase; Region: CheB_methylest; pfam01339
258594000560	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
258594000561	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
258594000562	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
258594000563	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
258594000564	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
258594000565	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594000566	dimer interface [polypeptide binding]; other site
258594000567	putative CheW interface [polypeptide binding]; other site
258594000568	2 probable transmembrane helices predicted byTMHMM2.0
258594000569	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
258594000570	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
258594000571	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
258594000572	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
258594000573	putative binding surface; other site
258594000574	active site
258594000575	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
258594000576	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594000577	ATP binding site [chemical binding]; other site
258594000578	Mg2+ binding site [ion binding]; other site
258594000579	G-X-G motif; other site
258594000580	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
258594000581	Response regulator receiver domain; Region: Response_reg; pfam00072
258594000582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594000583	active site
258594000584	phosphorylation site [posttranslational modification]
258594000585	intermolecular recognition site; other site
258594000586	dimerization interface [polypeptide binding]; other site
258594000587	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
258594000588	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
258594000589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594000590	active site
258594000591	phosphorylation site [posttranslational modification]
258594000592	intermolecular recognition site; other site
258594000593	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
258594000594	Zn2+ binding site [ion binding]; other site
258594000595	Mg2+ binding site [ion binding]; other site
258594000596	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
258594000597	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
258594000598	TOBE domain; Region: TOBE; cl01440
258594000599	TOBE domain; Region: TOBE; cl01440
258594000600	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
258594000601	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
258594000602	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
258594000603	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
258594000604	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
258594000605	ABC-ATPase subunit  interface; other site
258594000606	dimer interface [polypeptide binding]; other site
258594000607	putative PBP binding regions; other site
258594000608	8 probable transmembrane helices predicted byTMHMM2.0
258594000609	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
258594000610	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
258594000611	putative metal binding site [ion binding]; other site
258594000612	2 probable transmembrane helices predicted byTMHMM2.0
258594000613	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
258594000614	homodimer interaction site [polypeptide binding]; other site
258594000615	cofactor binding site; other site
258594000616	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
258594000617	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594000618	N-terminal plug; other site
258594000619	ligand-binding site [chemical binding]; other site
258594000620	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
258594000621	3 probable transmembrane helices predicted byTMHMM2.0
258594000622	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
258594000623	TolR protein; Region: tolR; TIGR02801
258594000624	1 probable transmembrane helix predicted byTMHMM2.0
258594000625	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
258594000626	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
258594000627	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
258594000628	nucleotide binding site [chemical binding]; other site
258594000629	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
258594000630	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
258594000631	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
258594000632	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
258594000633	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
258594000634	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
258594000635	EamA-like transporter family; Region: EamA; cl17759
258594000636	10 probable transmembrane helices predicted byTMHMM2.0
258594000637	GTPase CgtA; Reviewed; Region: obgE; PRK12299
258594000638	GTP1/OBG; Region: GTP1_OBG; pfam01018
258594000639	Obg GTPase; Region: Obg; cd01898
258594000640	G1 box; other site
258594000641	GTP/Mg2+ binding site [chemical binding]; other site
258594000642	Switch I region; other site
258594000643	G2 box; other site
258594000644	G3 box; other site
258594000645	Switch II region; other site
258594000646	G4 box; other site
258594000647	G5 box; other site
258594000648	gamma-glutamyl kinase; Provisional; Region: PRK05429
258594000649	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
258594000650	nucleotide binding site [chemical binding]; other site
258594000651	homotetrameric interface [polypeptide binding]; other site
258594000652	putative phosphate binding site [ion binding]; other site
258594000653	putative allosteric binding site; other site
258594000654	PUA domain; Region: PUA; pfam01472
258594000655	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
258594000656	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
258594000657	putative catalytic cysteine [active]
258594000658	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
258594000659	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
258594000660	active site
258594000661	(T/H)XGH motif; other site
258594000662	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
258594000663	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
258594000664	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
258594000665	Peptidase family M23; Region: Peptidase_M23; pfam01551
258594000666	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
258594000667	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
258594000668	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
258594000669	protein binding site [polypeptide binding]; other site
258594000670	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
258594000671	Catalytic dyad [active]
258594000672	1 probable transmembrane helix predicted byTMHMM2.0
258594000673	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
258594000674	putative active site [active]
258594000675	NodB motif; other site
258594000676	1 probable transmembrane helix predicted byTMHMM2.0
258594000677	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
258594000678	putative active site [active]
258594000679	Ap4A binding site [chemical binding]; other site
258594000680	nudix motif; other site
258594000681	putative metal binding site [ion binding]; other site
258594000682	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
258594000683	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
258594000684	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
258594000685	NAD binding site [chemical binding]; other site
258594000686	putative substrate binding site 2 [chemical binding]; other site
258594000687	putative substrate binding site 1 [chemical binding]; other site
258594000688	active site
258594000689	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
258594000690	putative active site [active]
258594000691	Ap4A binding site [chemical binding]; other site
258594000692	nudix motif; other site
258594000693	putative metal binding site [ion binding]; other site
258594000694	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13448
258594000695	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
258594000696	gamma subunit interface [polypeptide binding]; other site
258594000697	epsilon subunit interface [polypeptide binding]; other site
258594000698	LBP interface [polypeptide binding]; other site
258594000699	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
258594000700	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
258594000701	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
258594000702	alpha subunit interaction interface [polypeptide binding]; other site
258594000703	Walker A motif; other site
258594000704	ATP binding site [chemical binding]; other site
258594000705	Walker B motif; other site
258594000706	inhibitor binding site; inhibition site
258594000707	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
258594000708	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
258594000709	core domain interface [polypeptide binding]; other site
258594000710	delta subunit interface [polypeptide binding]; other site
258594000711	epsilon subunit interface [polypeptide binding]; other site
258594000712	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
258594000713	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
258594000714	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
258594000715	beta subunit interaction interface [polypeptide binding]; other site
258594000716	Walker A motif; other site
258594000717	ATP binding site [chemical binding]; other site
258594000718	Walker B motif; other site
258594000719	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
258594000720	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
258594000721	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
258594000722	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
258594000723	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
258594000724	1 probable transmembrane helix predicted byTMHMM2.0
258594000725	primosome assembly protein PriA; Validated; Region: PRK05580
258594000726	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
258594000727	ATP binding site [chemical binding]; other site
258594000728	putative Mg++ binding site [ion binding]; other site
258594000729	helicase superfamily c-terminal domain; Region: HELICc; smart00490
258594000730	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
258594000731	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
258594000732	active site
258594000733	DNA binding site [nucleotide binding]
258594000734	Int/Topo IB signature motif; other site
258594000735	IS element
258594000736	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
258594000737	3 probable transmembrane helices predicted byTMHMM2.0
258594000738	3 probable transmembrane helices predicted byTMHMM2.0
258594000739	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115
258594000740	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
258594000741	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
258594000742	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
258594000743	short chain dehydrogenase; Provisional; Region: PRK06123
258594000744	classical (c) SDRs; Region: SDR_c; cd05233
258594000745	NAD(P) binding site [chemical binding]; other site
258594000746	active site
258594000747	MAPEG family; Region: MAPEG; cl09190
258594000748	4 probable transmembrane helices predicted byTMHMM2.0
258594000749	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
258594000750	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
258594000751	E3 interaction surface; other site
258594000752	lipoyl attachment site [posttranslational modification]; other site
258594000753	e3 binding domain; Region: E3_binding; pfam02817
258594000754	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
258594000755	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
258594000756	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
258594000757	TPP-binding site [chemical binding]; other site
258594000758	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
258594000759	dimer interface [polypeptide binding]; other site
258594000760	PYR/PP interface [polypeptide binding]; other site
258594000761	TPP binding site [chemical binding]; other site
258594000762	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
258594000763	CoA binding domain; Region: CoA_binding; smart00881
258594000764	CoA-ligase; Region: Ligase_CoA; pfam00549
258594000765	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
258594000766	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
258594000767	CoA-ligase; Region: Ligase_CoA; pfam00549
258594000768	malate dehydrogenase; Reviewed; Region: PRK06223
258594000769	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
258594000770	NAD(P) binding site [chemical binding]; other site
258594000771	dimer interface [polypeptide binding]; other site
258594000772	tetramer (dimer of dimers) interface [polypeptide binding]; other site
258594000773	substrate binding site [chemical binding]; other site
258594000774	Predicted ATPase [General function prediction only]; Region: COG1485
258594000775	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
258594000776	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
258594000777	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
258594000778	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
258594000779	active site
258594000780	catalytic triad [active]
258594000781	oxyanion hole [active]
258594000782	switch loop; other site
258594000783	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
258594000784	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
258594000785	Walker A/P-loop; other site
258594000786	ATP binding site [chemical binding]; other site
258594000787	Q-loop/lid; other site
258594000788	ABC transporter signature motif; other site
258594000789	Walker B; other site
258594000790	D-loop; other site
258594000791	H-loop/switch region; other site
258594000792	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
258594000793	FtsX-like permease family; Region: FtsX; pfam02687
258594000794	10 probable transmembrane helices predicted byTMHMM2.0
258594000795	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
258594000796	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
258594000797	7 probable transmembrane helices predicted byTMHMM2.0
258594000798	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
258594000799	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594000800	Coenzyme A binding pocket [chemical binding]; other site
258594000801	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
258594000802	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
258594000803	aconitate hydratase; Validated; Region: PRK09277
258594000804	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
258594000805	substrate binding site [chemical binding]; other site
258594000806	ligand binding site [chemical binding]; other site
258594000807	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
258594000808	substrate binding site [chemical binding]; other site
258594000809	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
258594000810	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594000811	Walker A/P-loop; other site
258594000812	ATP binding site [chemical binding]; other site
258594000813	Q-loop/lid; other site
258594000814	ABC transporter signature motif; other site
258594000815	Walker B; other site
258594000816	D-loop; other site
258594000817	H-loop/switch region; other site
258594000818	heme exporter protein CcmB; Region: ccmB; TIGR01190
258594000819	6 probable transmembrane helices predicted byTMHMM2.0
258594000820	heme exporter protein CcmC; Region: ccmC; TIGR01191
258594000821	6 probable transmembrane helices predicted byTMHMM2.0
258594000822	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
258594000823	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
258594000824	catalytic residues [active]
258594000825	central insert; other site
258594000826	1 probable transmembrane helix predicted byTMHMM2.0
258594000827	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
258594000828	intracellular septation protein A; Reviewed; Region: PRK00259
258594000829	5 probable transmembrane helices predicted byTMHMM2.0
258594000830	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
258594000831	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
258594000832	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
258594000833	P loop; other site
258594000834	GTP binding site [chemical binding]; other site
258594000835	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
258594000836	active site
258594000837	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
258594000838	acetyl-CoA synthetase; Provisional; Region: PRK00174
258594000839	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
258594000840	active site
258594000841	CoA binding site [chemical binding]; other site
258594000842	acyl-activating enzyme (AAE) consensus motif; other site
258594000843	AMP binding site [chemical binding]; other site
258594000844	acetate binding site [chemical binding]; other site
258594000845	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
258594000846	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
258594000847	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
258594000848	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
258594000849	ligand binding site [chemical binding]; other site
258594000850	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
258594000851	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
258594000852	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
258594000853	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
258594000854	catalytic loop [active]
258594000855	iron binding site [ion binding]; other site
258594000856	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
258594000857	L-aspartate oxidase; Provisional; Region: PRK06175
258594000858	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
258594000859	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
258594000860	putative SdhC subunit interface [polypeptide binding]; other site
258594000861	putative proximal heme binding site [chemical binding]; other site
258594000862	putative Iron-sulfur protein interface [polypeptide binding]; other site
258594000863	putative proximal quinone binding site; other site
258594000864	3 probable transmembrane helices predicted byTMHMM2.0
258594000865	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
258594000866	Iron-sulfur protein interface; other site
258594000867	proximal quinone binding site [chemical binding]; other site
258594000868	SdhD (CybS) interface [polypeptide binding]; other site
258594000869	proximal heme binding site [chemical binding]; other site
258594000870	3 probable transmembrane helices predicted byTMHMM2.0
258594000871	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
258594000872	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
258594000873	5 probable transmembrane helices predicted byTMHMM2.0
258594000874	malonyl-CoA synthase; Validated; Region: PRK07514
258594000875	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
258594000876	acyl-activating enzyme (AAE) consensus motif; other site
258594000877	active site
258594000878	AMP binding site [chemical binding]; other site
258594000879	CoA binding site [chemical binding]; other site
258594000880	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
258594000881	Fasciclin domain; Region: Fasciclin; pfam02469
258594000882	1 probable transmembrane helix predicted byTMHMM2.0
258594000883	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
258594000884	4 probable transmembrane helices predicted byTMHMM2.0
258594000885	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
258594000886	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
258594000887	Moco binding site; other site
258594000888	metal coordination site [ion binding]; other site
258594000889	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
258594000890	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
258594000891	E-class dimer interface [polypeptide binding]; other site
258594000892	P-class dimer interface [polypeptide binding]; other site
258594000893	active site
258594000894	Cu2+ binding site [ion binding]; other site
258594000895	Zn2+ binding site [ion binding]; other site
258594000896	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
258594000897	12 probable transmembrane helices predicted byTMHMM2.0
258594000898	tartrate dehydrogenase; Region: TTC; TIGR02089
258594000899	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
258594000900	1 probable transmembrane helix predicted byTMHMM2.0
258594000901	1 probable transmembrane helix predicted byTMHMM2.0
258594000902	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
258594000903	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
258594000904	hypothetical protein; Provisional; Region: PRK05208
258594000905	3 probable transmembrane helices predicted byTMHMM2.0
258594000906	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
258594000907	active site clefts [active]
258594000908	zinc binding site [ion binding]; other site
258594000909	dimer interface [polypeptide binding]; other site
258594000910	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
258594000911	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
258594000912	dimerization interface [polypeptide binding]; other site
258594000913	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594000914	dimer interface [polypeptide binding]; other site
258594000915	putative CheW interface [polypeptide binding]; other site
258594000916	2 probable transmembrane helices predicted byTMHMM2.0
258594000917	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
258594000918	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
258594000919	substrate binding site [chemical binding]; other site
258594000920	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
258594000921	1 probable transmembrane helix predicted byTMHMM2.0
258594000922	1 probable transmembrane helix predicted byTMHMM2.0
258594000923	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
258594000924	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
258594000925	substrate binding site [chemical binding]; other site
258594000926	ligand binding site [chemical binding]; other site
258594000927	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
258594000928	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
258594000929	RimM N-terminal domain; Region: RimM; pfam01782
258594000930	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
258594000931	PRC-barrel domain; Region: PRC; pfam05239
258594000932	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
258594000933	signal recognition particle protein; Provisional; Region: PRK10867
258594000934	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
258594000935	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
258594000936	P loop; other site
258594000937	GTP binding site [chemical binding]; other site
258594000938	Signal peptide binding domain; Region: SRP_SPB; pfam02978
258594000939	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
258594000940	putative active site [active]
258594000941	homotetrameric interface [polypeptide binding]; other site
258594000942	metal binding site [ion binding]; metal-binding site
258594000943	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
258594000944	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
258594000945	Uncharacterized conserved protein [Function unknown]; Region: COG2968
258594000946	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
258594000947	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
258594000948	1 probable transmembrane helix predicted byTMHMM2.0
258594000949	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
258594000950	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
258594000951	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
258594000952	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
258594000953	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
258594000954	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594000955	FeS/SAM binding site; other site
258594000956	Predicted methyltransferase [General function prediction only]; Region: COG3897
258594000957	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594000958	S-adenosylmethionine binding site [chemical binding]; other site
258594000959	EVE domain; Region: EVE; pfam01878
258594000960	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
258594000961	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
258594000962	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
258594000963	UGMP family protein; Validated; Region: PRK09604
258594000964	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
258594000965	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
258594000966	active site
258594000967	1 probable transmembrane helix predicted byTMHMM2.0
258594000968	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
258594000969	HemY protein N-terminus; Region: HemY_N; pfam07219
258594000970	2 probable transmembrane helices predicted byTMHMM2.0
258594000971	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
258594000972	dimerization interface [polypeptide binding]; other site
258594000973	2 probable transmembrane helices predicted byTMHMM2.0
258594000974	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
258594000975	Ribulose bisphosphate carboxylase like proteins from phototrophic bacteria; Region: RLP_Photo; cd08208
258594000976	dimer interface [polypeptide binding]; other site
258594000977	active site
258594000978	catalytic residue [active]
258594000979	metal binding site [ion binding]; metal-binding site
258594000980	Uncharacterized conserved protein [Function unknown]; Region: COG0432
258594000981	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
258594000982	11 probable transmembrane helices predicted byTMHMM2.0
258594000983	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
258594000984	10 probable transmembrane helices predicted byTMHMM2.0
258594000985	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
258594000986	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
258594000987	catalytic residues [active]
258594000988	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
258594000989	Uncharacterized conserved protein [Function unknown]; Region: COG2835
258594000990	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
258594000991	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
258594000992	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
258594000993	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
258594000994	active site
258594000995	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
258594000996	catalytic triad [active]
258594000997	dimer interface [polypeptide binding]; other site
258594000998	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
258594000999	Nitrogen regulatory protein P-II; Region: P-II; smart00938
258594001000	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
258594001001	12 probable transmembrane helices predicted byTMHMM2.0
258594001002	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
258594001003	Nitrogen regulatory protein P-II; Region: P-II; smart00938
258594001004	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
258594001005	12 probable transmembrane helices predicted byTMHMM2.0
258594001006	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
258594001007	active site
258594001008	NTP binding site [chemical binding]; other site
258594001009	metal binding triad [ion binding]; metal-binding site
258594001010	antibiotic binding site [chemical binding]; other site
258594001011	Protein of unknown function DUF86; Region: DUF86; cl01031
258594001012	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
258594001013	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
258594001014	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594001015	homodimer interface [polypeptide binding]; other site
258594001016	catalytic residue [active]
258594001017	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
258594001018	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
258594001019	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
258594001020	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
258594001021	5 probable transmembrane helices predicted byTMHMM2.0
258594001022	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
258594001023	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
258594001024	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
258594001025	putative catalytic site [active]
258594001026	putative phosphate binding site [ion binding]; other site
258594001027	active site
258594001028	metal binding site A [ion binding]; metal-binding site
258594001029	DNA binding site [nucleotide binding]
258594001030	putative AP binding site [nucleotide binding]; other site
258594001031	putative metal binding site B [ion binding]; other site
258594001032	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594001033	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594001034	ligand binding site [chemical binding]; other site
258594001035	flexible hinge region; other site
258594001036	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
258594001037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594001038	active site
258594001039	phosphorylation site [posttranslational modification]
258594001040	intermolecular recognition site; other site
258594001041	dimerization interface [polypeptide binding]; other site
258594001042	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
258594001043	DNA binding site [nucleotide binding]
258594001044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
258594001045	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
258594001046	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
258594001047	catalytic residue [active]
258594001048	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
258594001049	dimerization interface [polypeptide binding]; other site
258594001050	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594001051	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594001052	metal binding site [ion binding]; metal-binding site
258594001053	active site
258594001054	I-site; other site
258594001055	1 probable transmembrane helix predicted byTMHMM2.0
258594001056	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
258594001057	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
258594001058	HIGH motif; other site
258594001059	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
258594001060	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
258594001061	active site
258594001062	KMSKS motif; other site
258594001063	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
258594001064	tRNA binding surface [nucleotide binding]; other site
258594001065	Lipopolysaccharide-assembly; Region: LptE; cl01125
258594001066	1 probable transmembrane helix predicted byTMHMM2.0
258594001067	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
258594001068	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
258594001069	1 probable transmembrane helix predicted byTMHMM2.0
258594001070	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
258594001071	ParB-like nuclease domain; Region: ParB; smart00470
258594001072	KorB domain; Region: KorB; pfam08535
258594001073	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
258594001074	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
258594001075	P-loop; other site
258594001076	Magnesium ion binding site [ion binding]; other site
258594001077	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
258594001078	Magnesium ion binding site [ion binding]; other site
258594001079	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
258594001080	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
258594001081	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
258594001082	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
258594001083	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
258594001084	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
258594001085	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
258594001086	trmE is a tRNA modification GTPase; Region: trmE; cd04164
258594001087	G1 box; other site
258594001088	GTP/Mg2+ binding site [chemical binding]; other site
258594001089	Switch I region; other site
258594001090	G2 box; other site
258594001091	Switch II region; other site
258594001092	G3 box; other site
258594001093	G4 box; other site
258594001094	G5 box; other site
258594001095	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
258594001096	transcription termination factor Rho; Provisional; Region: rho; PRK09376
258594001097	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
258594001098	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
258594001099	RNA binding site [nucleotide binding]; other site
258594001100	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
258594001101	multimer interface [polypeptide binding]; other site
258594001102	Walker A motif; other site
258594001103	ATP binding site [chemical binding]; other site
258594001104	Walker B motif; other site
258594001105	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
258594001106	4 probable transmembrane helices predicted byTMHMM2.0
258594001107	PEP synthetase regulatory protein; Provisional; Region: PRK05339
258594001108	Maf-like protein; Region: Maf; pfam02545
258594001109	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
258594001110	active site
258594001111	dimer interface [polypeptide binding]; other site
258594001112	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
258594001113	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
258594001114	CoA-binding site [chemical binding]; other site
258594001115	ATP-binding [chemical binding]; other site
258594001116	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
258594001117	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
258594001118	active site
258594001119	catalytic site [active]
258594001120	substrate binding site [chemical binding]; other site
258594001121	preprotein translocase subunit SecB; Validated; Region: PRK05751
258594001122	SecA binding site; other site
258594001123	Preprotein binding site; other site
258594001124	Tim44-like domain; Region: Tim44; pfam04280
258594001125	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
258594001126	MltA specific insert domain; Region: MltA; smart00925
258594001127	3D domain; Region: 3D; pfam06725
258594001128	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
258594001129	Smr domain; Region: Smr; pfam01713
258594001130	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
258594001131	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594001132	Walker A motif; other site
258594001133	ATP binding site [chemical binding]; other site
258594001134	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594001135	Walker B motif; other site
258594001136	arginine finger; other site
258594001137	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
258594001138	hypothetical protein; Provisional; Region: PRK00944
258594001139	3 probable transmembrane helices predicted byTMHMM2.0
258594001140	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
258594001141	active site
258594001142	HslU subunit interaction site [polypeptide binding]; other site
258594001143	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
258594001144	putative active site pocket [active]
258594001145	4-fold oligomerization interface [polypeptide binding]; other site
258594001146	metal binding residues [ion binding]; metal-binding site
258594001147	3-fold/trimer interface [polypeptide binding]; other site
258594001148	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
258594001149	2 probable transmembrane helices predicted byTMHMM2.0
258594001150	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
258594001151	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
258594001152	putative active site [active]
258594001153	oxyanion strand; other site
258594001154	catalytic triad [active]
258594001155	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
258594001156	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
258594001157	catalytic residues [active]
258594001158	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
258594001159	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
258594001160	substrate binding site [chemical binding]; other site
258594001161	glutamase interaction surface [polypeptide binding]; other site
258594001162	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
258594001163	metal binding site [ion binding]; metal-binding site
258594001164	pantothenate kinase; Provisional; Region: PRK05439
258594001165	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
258594001166	ATP-binding site [chemical binding]; other site
258594001167	CoA-binding site [chemical binding]; other site
258594001168	Mg2+-binding site [ion binding]; other site
258594001169	Putative hemolysin [General function prediction only]; Region: COG3176
258594001170	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594001171	dimer interface [polypeptide binding]; other site
258594001172	phosphorylation site [posttranslational modification]
258594001173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594001174	ATP binding site [chemical binding]; other site
258594001175	Mg2+ binding site [ion binding]; other site
258594001176	G-X-G motif; other site
258594001177	Response regulator receiver domain; Region: Response_reg; pfam00072
258594001178	Response regulator receiver domain; Region: Response_reg; pfam00072
258594001179	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594001180	active site
258594001181	phosphorylation site [posttranslational modification]
258594001182	intermolecular recognition site; other site
258594001183	dimerization interface [polypeptide binding]; other site
258594001184	2 probable transmembrane helices predicted byTMHMM2.0
258594001185	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
258594001186	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
258594001187	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594001188	Walker A motif; other site
258594001189	ATP binding site [chemical binding]; other site
258594001190	Walker B motif; other site
258594001191	arginine finger; other site
258594001192	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
258594001193	Autoinducer synthetase; Region: Autoind_synth; cl17404
258594001194	Autoinducer binding domain; Region: Autoind_bind; pfam03472
258594001195	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
258594001196	DNA binding residues [nucleotide binding]
258594001197	dimerization interface [polypeptide binding]; other site
258594001198	glutathione synthetase; Provisional; Region: PRK05246
258594001199	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
258594001200	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
258594001201	hypothetical protein; Reviewed; Region: PRK12497
258594001202	Predicted methyltransferases [General function prediction only]; Region: COG0313
258594001203	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
258594001204	putative SAM binding site [chemical binding]; other site
258594001205	putative homodimer interface [polypeptide binding]; other site
258594001206	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594001207	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
258594001208	putative ligand binding site [chemical binding]; other site
258594001209	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
258594001210	Predicted transcriptional regulators [Transcription]; Region: COG1733
258594001211	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
258594001212	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
258594001213	HemN C-terminal domain; Region: HemN_C; pfam06969
258594001214	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
258594001215	active site
258594001216	dimerization interface [polypeptide binding]; other site
258594001217	ribonuclease PH; Reviewed; Region: rph; PRK00173
258594001218	Ribonuclease PH; Region: RNase_PH_bact; cd11362
258594001219	hexamer interface [polypeptide binding]; other site
258594001220	active site
258594001221	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
258594001222	heat shock protein GrpE; Provisional; Region: PRK14141
258594001223	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
258594001224	dimer interface [polypeptide binding]; other site
258594001225	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
258594001226	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
258594001227	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
258594001228	nucleotide binding site [chemical binding]; other site
258594001229	NEF interaction site [polypeptide binding]; other site
258594001230	SBD interface [polypeptide binding]; other site
258594001231	chaperone protein DnaJ; Provisional; Region: PRK10767
258594001232	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
258594001233	HSP70 interaction site [polypeptide binding]; other site
258594001234	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
258594001235	substrate binding site [polypeptide binding]; other site
258594001236	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
258594001237	Zn binding sites [ion binding]; other site
258594001238	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
258594001239	dimer interface [polypeptide binding]; other site
258594001240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594001241	S-adenosylmethionine binding site [chemical binding]; other site
258594001242	Predicted flavoprotein [General function prediction only]; Region: COG0431
258594001243	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
258594001244	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
258594001245	active site
258594001246	dimer interface [polypeptide binding]; other site
258594001247	Uncharacterized conserved protein [Function unknown]; Region: COG5470
258594001248	dihydrodipicolinate reductase; Provisional; Region: PRK00048
258594001249	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
258594001250	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
258594001251	phosphoglyceromutase; Provisional; Region: PRK05434
258594001252	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
258594001253	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
258594001254	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
258594001255	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
258594001256	DNA binding site [nucleotide binding]
258594001257	active site
258594001258	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
258594001259	2 probable transmembrane helices predicted byTMHMM2.0
258594001260	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
258594001261	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
258594001262	minor groove reading motif; other site
258594001263	helix-hairpin-helix signature motif; other site
258594001264	substrate binding pocket [chemical binding]; other site
258594001265	active site
258594001266	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
258594001267	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
258594001268	putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056
258594001269	CysZ-like protein; Reviewed; Region: PRK12768
258594001270	4 probable transmembrane helices predicted byTMHMM2.0
258594001271	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
258594001272	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
258594001273	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
258594001274	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
258594001275	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
258594001276	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
258594001277	cofactor binding site; other site
258594001278	DNA binding site [nucleotide binding]
258594001279	substrate interaction site [chemical binding]; other site
258594001280	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
258594001281	additional DNA contacts [nucleotide binding]; other site
258594001282	mismatch recognition site; other site
258594001283	active site
258594001284	zinc binding site [ion binding]; other site
258594001285	DNA intercalation site [nucleotide binding]; other site
258594001286	GTP-binding protein LepA; Provisional; Region: PRK05433
258594001287	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
258594001288	G1 box; other site
258594001289	putative GEF interaction site [polypeptide binding]; other site
258594001290	GTP/Mg2+ binding site [chemical binding]; other site
258594001291	Switch I region; other site
258594001292	G2 box; other site
258594001293	G3 box; other site
258594001294	Switch II region; other site
258594001295	G4 box; other site
258594001296	G5 box; other site
258594001297	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
258594001298	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
258594001299	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
258594001300	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
258594001301	9 probable transmembrane helices predicted byTMHMM2.0
258594001302	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
258594001303	dimerization domain swap beta strand [polypeptide binding]; other site
258594001304	regulatory protein interface [polypeptide binding]; other site
258594001305	active site
258594001306	regulatory phosphorylation site [posttranslational modification]; other site
258594001307	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
258594001308	active pocket/dimerization site; other site
258594001309	active site
258594001310	phosphorylation site [posttranslational modification]
258594001311	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
258594001312	Hpr binding site; other site
258594001313	active site
258594001314	homohexamer subunit interaction site [polypeptide binding]; other site
258594001315	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
258594001316	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
258594001317	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594001318	HAMP domain; Region: HAMP; pfam00672
258594001319	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594001320	dimer interface [polypeptide binding]; other site
258594001321	phosphorylation site [posttranslational modification]
258594001322	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594001323	ATP binding site [chemical binding]; other site
258594001324	Mg2+ binding site [ion binding]; other site
258594001325	G-X-G motif; other site
258594001326	2 probable transmembrane helices predicted byTMHMM2.0
258594001327	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
258594001328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594001329	active site
258594001330	phosphorylation site [posttranslational modification]
258594001331	intermolecular recognition site; other site
258594001332	dimerization interface [polypeptide binding]; other site
258594001333	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
258594001334	DNA binding site [nucleotide binding]
258594001335	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
258594001336	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
258594001337	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
258594001338	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
258594001339	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
258594001340	active site
258594001341	substrate-binding site [chemical binding]; other site
258594001342	metal-binding site [ion binding]
258594001343	ATP binding site [chemical binding]; other site
258594001344	1 probable transmembrane helix predicted byTMHMM2.0
258594001345	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
258594001346	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
258594001347	putative active site [active]
258594001348	putative catalytic site [active]
258594001349	putative Mg binding site IVb [ion binding]; other site
258594001350	putative phosphate binding site [ion binding]; other site
258594001351	putative DNA binding site [nucleotide binding]; other site
258594001352	putative Mg binding site IVa [ion binding]; other site
258594001353	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
258594001354	8 probable transmembrane helices predicted byTMHMM2.0
258594001355	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
258594001356	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
258594001357	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
258594001358	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594001359	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
258594001360	DNA binding residues [nucleotide binding]
258594001361	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
258594001362	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
258594001363	RNA binding surface [nucleotide binding]; other site
258594001364	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
258594001365	active site
258594001366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594001367	ATP binding site [chemical binding]; other site
258594001368	Mg2+ binding site [ion binding]; other site
258594001369	G-X-G motif; other site
258594001370	PAS domain; Region: PAS_9; pfam13426
258594001371	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
258594001372	PAS domain; Region: PAS_9; pfam13426
258594001373	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
258594001374	PAS fold; Region: PAS_3; pfam08447
258594001375	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594001376	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594001377	metal binding site [ion binding]; metal-binding site
258594001378	active site
258594001379	I-site; other site
258594001380	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594001381	methionine gamma-lyase; Provisional; Region: PRK07503
258594001382	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
258594001383	homodimer interface [polypeptide binding]; other site
258594001384	substrate-cofactor binding pocket; other site
258594001385	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594001386	catalytic residue [active]
258594001387	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
258594001388	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594001389	putative DNA binding site [nucleotide binding]; other site
258594001390	putative Zn2+ binding site [ion binding]; other site
258594001391	AsnC family; Region: AsnC_trans_reg; pfam01037
258594001392	thioredoxin 2; Provisional; Region: PRK10996
258594001393	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
258594001394	catalytic residues [active]
258594001395	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
258594001396	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
258594001397	putative NAD(P) binding site [chemical binding]; other site
258594001398	putative substrate binding site [chemical binding]; other site
258594001399	catalytic Zn binding site [ion binding]; other site
258594001400	structural Zn binding site [ion binding]; other site
258594001401	ChaB; Region: ChaB; pfam06150
258594001402	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
258594001403	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
258594001404	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
258594001405	Ligand Binding Site [chemical binding]; other site
258594001406	1 probable transmembrane helix predicted byTMHMM2.0
258594001407	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
258594001408	alpha-galactosidase; Provisional; Region: PRK15076
258594001409	NAD binding site [chemical binding]; other site
258594001410	sugar binding site [chemical binding]; other site
258594001411	divalent metal binding site [ion binding]; other site
258594001412	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
258594001413	dimer interface [polypeptide binding]; other site
258594001414	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
258594001415	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
258594001416	putative substrate binding site [chemical binding]; other site
258594001417	putative ATP binding site [chemical binding]; other site
258594001418	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
258594001419	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
258594001420	putative molybdopterin cofactor binding site [chemical binding]; other site
258594001421	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
258594001422	putative molybdopterin cofactor binding site; other site
258594001423	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
258594001424	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
258594001425	ligand binding site; other site
258594001426	oligomer interface; other site
258594001427	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
258594001428	dimer interface [polypeptide binding]; other site
258594001429	N-terminal domain interface [polypeptide binding]; other site
258594001430	sulfate 1 binding site; other site
258594001431	glycogen synthase; Provisional; Region: PRK14099
258594001432	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
258594001433	ADP-binding pocket [chemical binding]; other site
258594001434	homodimer interface [polypeptide binding]; other site
258594001435	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
258594001436	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594001437	substrate binding site [chemical binding]; other site
258594001438	oxyanion hole (OAH) forming residues; other site
258594001439	trimer interface [polypeptide binding]; other site
258594001440	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
258594001441	1 probable transmembrane helix predicted byTMHMM2.0
258594001442	hypothetical protein; Reviewed; Region: PRK00024
258594001443	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
258594001444	MPN+ (JAMM) motif; other site
258594001445	Zinc-binding site [ion binding]; other site
258594001446	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
258594001447	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
258594001448	putative DNA binding site [nucleotide binding]; other site
258594001449	putative homodimer interface [polypeptide binding]; other site
258594001450	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
258594001451	active site
258594001452	potassium/proton antiporter; Reviewed; Region: PRK05326
258594001453	Transporter associated domain; Region: CorC_HlyC; smart01091
258594001454	11 probable transmembrane helices predicted byTMHMM2.0
258594001455	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
258594001456	1 probable transmembrane helix predicted byTMHMM2.0
258594001457	PAS fold; Region: PAS_7; pfam12860
258594001458	PAS domain S-box; Region: sensory_box; TIGR00229
258594001459	PAS domain; Region: PAS; smart00091
258594001460	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594001461	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594001462	metal binding site [ion binding]; metal-binding site
258594001463	active site
258594001464	I-site; other site
258594001465	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594001466	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
258594001467	Alkaline phosphatase homologues; Region: alkPPc; smart00098
258594001468	active site
258594001469	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
258594001470	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
258594001471	argininosuccinate synthase; Provisional; Region: PRK13820
258594001472	ANP binding site [chemical binding]; other site
258594001473	Substrate Binding Site II [chemical binding]; other site
258594001474	Substrate Binding Site I [chemical binding]; other site
258594001475	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
258594001476	active site
258594001477	4 probable transmembrane helices predicted byTMHMM2.0
258594001478	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
258594001479	4 probable transmembrane helices predicted byTMHMM2.0
258594001480	HD domain; Region: HD_3; pfam13023
258594001481	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
258594001482	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594001483	FeS/SAM binding site; other site
258594001484	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
258594001485	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594001486	short chain dehydrogenase; Provisional; Region: PRK07677
258594001487	NAD(P) binding site [chemical binding]; other site
258594001488	active site
258594001489	Helix-turn-helix domain; Region: HTH_28; pfam13518
258594001490	Winged helix-turn helix; Region: HTH_29; pfam13551
258594001491	Homeodomain-like domain; Region: HTH_32; pfam13565
258594001492	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
258594001493	Integrase core domain; Region: rve; pfam00665
258594001494	Integrase core domain; Region: rve_3; pfam13683
258594001495	IS element
258594001496	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
258594001497	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
258594001498	NAD(P) binding site [chemical binding]; other site
258594001499	carotene isomerase; Region: carot_isom; TIGR02730
258594001500	hydroxyglutarate oxidase; Provisional; Region: PRK11728
258594001501	5 probable transmembrane helices predicted byTMHMM2.0
258594001502	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594001503	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594001504	1 probable transmembrane helix predicted byTMHMM2.0
258594001505	Uncharacterized conserved protein [Function unknown]; Region: COG3339
258594001506	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
258594001507	aromatic arch; other site
258594001508	DCoH dimer interaction site [polypeptide binding]; other site
258594001509	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
258594001510	DCoH tetramer interaction site [polypeptide binding]; other site
258594001511	substrate binding site [chemical binding]; other site
258594001512	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
258594001513	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
258594001514	2 probable transmembrane helices predicted byTMHMM2.0
258594001515	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
258594001516	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
258594001517	4 probable transmembrane helices predicted byTMHMM2.0
258594001518	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
258594001519	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594001520	N-terminal plug; other site
258594001521	ligand-binding site [chemical binding]; other site
258594001522	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
258594001523	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
258594001524	G1 box; other site
258594001525	putative GEF interaction site [polypeptide binding]; other site
258594001526	GTP/Mg2+ binding site [chemical binding]; other site
258594001527	Switch I region; other site
258594001528	G2 box; other site
258594001529	G3 box; other site
258594001530	Switch II region; other site
258594001531	G4 box; other site
258594001532	G5 box; other site
258594001533	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
258594001534	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
258594001535	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
258594001536	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
258594001537	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
258594001538	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
258594001539	dimer interface [polypeptide binding]; other site
258594001540	substrate binding site [chemical binding]; other site
258594001541	metal binding sites [ion binding]; metal-binding site
258594001542	hypothetical protein; Provisional; Region: PRK08262
258594001543	M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674
258594001544	metal binding site [ion binding]; metal-binding site
258594001545	1 probable transmembrane helix predicted byTMHMM2.0
258594001546	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
258594001547	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
258594001548	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
258594001549	homodimer interface [polypeptide binding]; other site
258594001550	NADP binding site [chemical binding]; other site
258594001551	substrate binding site [chemical binding]; other site
258594001552	hypothetical protein; Validated; Region: PRK01310
258594001553	YGGT family; Region: YGGT; pfam02325
258594001554	2 probable transmembrane helices predicted byTMHMM2.0
258594001555	enoyl-CoA hydratase; Provisional; Region: PRK06210
258594001556	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594001557	substrate binding site [chemical binding]; other site
258594001558	oxyanion hole (OAH) forming residues; other site
258594001559	trimer interface [polypeptide binding]; other site
258594001560	SnoaL-like domain; Region: SnoaL_2; pfam12680
258594001561	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
258594001562	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
258594001563	catalytic triad [active]
258594001564	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
258594001565	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594001566	NAD(P) binding site [chemical binding]; other site
258594001567	active site
258594001568	2 probable transmembrane helices predicted byTMHMM2.0
258594001569	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
258594001570	putative metal binding site [ion binding]; other site
258594001571	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
258594001572	Cytochrome P450; Region: p450; cl12078
258594001573	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
258594001574	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
258594001575	dimerization interface [polypeptide binding]; other site
258594001576	ligand binding site [chemical binding]; other site
258594001577	NADP binding site [chemical binding]; other site
258594001578	catalytic site [active]
258594001579	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
258594001580	Bacterial SH3 domain; Region: SH3_4; pfam06347
258594001581	Bacterial SH3 domain; Region: SH3_4; pfam06347
258594001582	1 probable transmembrane helix predicted byTMHMM2.0
258594001583	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
258594001584	metal binding site 2 [ion binding]; metal-binding site
258594001585	putative DNA binding helix; other site
258594001586	metal binding site 1 [ion binding]; metal-binding site
258594001587	dimer interface [polypeptide binding]; other site
258594001588	structural Zn2+ binding site [ion binding]; other site
258594001589	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
258594001590	active site 1 [active]
258594001591	dimer interface [polypeptide binding]; other site
258594001592	active site 2 [active]
258594001593	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
258594001594	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
258594001595	dimer interface [polypeptide binding]; other site
258594001596	active site
258594001597	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
258594001598	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
258594001599	NAD binding site [chemical binding]; other site
258594001600	homotetramer interface [polypeptide binding]; other site
258594001601	homodimer interface [polypeptide binding]; other site
258594001602	substrate binding site [chemical binding]; other site
258594001603	active site
258594001604	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
258594001605	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
258594001606	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
258594001607	dimer interface [polypeptide binding]; other site
258594001608	active site
258594001609	heme binding site [chemical binding]; other site
258594001610	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
258594001611	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
258594001612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594001613	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
258594001614	dimerization interface [polypeptide binding]; other site
258594001615	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594001616	PAS domain; Region: PAS_9; pfam13426
258594001617	putative active site [active]
258594001618	heme pocket [chemical binding]; other site
258594001619	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
258594001620	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594001621	putative active site [active]
258594001622	heme pocket [chemical binding]; other site
258594001623	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594001624	putative active site [active]
258594001625	heme pocket [chemical binding]; other site
258594001626	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
258594001627	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594001628	dimer interface [polypeptide binding]; other site
258594001629	putative CheW interface [polypeptide binding]; other site
258594001630	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
258594001631	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
258594001632	RNase E interface [polypeptide binding]; other site
258594001633	trimer interface [polypeptide binding]; other site
258594001634	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
258594001635	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
258594001636	RNase E interface [polypeptide binding]; other site
258594001637	trimer interface [polypeptide binding]; other site
258594001638	active site
258594001639	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
258594001640	putative nucleic acid binding region [nucleotide binding]; other site
258594001641	G-X-X-G motif; other site
258594001642	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
258594001643	RNA binding site [nucleotide binding]; other site
258594001644	domain interface; other site
258594001645	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
258594001646	16S/18S rRNA binding site [nucleotide binding]; other site
258594001647	S13e-L30e interaction site [polypeptide binding]; other site
258594001648	25S rRNA binding site [nucleotide binding]; other site
258594001649	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
258594001650	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
258594001651	RNA binding site [nucleotide binding]; other site
258594001652	active site
258594001653	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
258594001654	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
258594001655	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
258594001656	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
258594001657	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
258594001658	G1 box; other site
258594001659	putative GEF interaction site [polypeptide binding]; other site
258594001660	GTP/Mg2+ binding site [chemical binding]; other site
258594001661	Switch I region; other site
258594001662	G2 box; other site
258594001663	G3 box; other site
258594001664	Switch II region; other site
258594001665	G4 box; other site
258594001666	G5 box; other site
258594001667	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
258594001668	Translation-initiation factor 2; Region: IF-2; pfam11987
258594001669	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
258594001670	hypothetical protein; Provisional; Region: PRK09190
258594001671	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
258594001672	putative RNA binding cleft [nucleotide binding]; other site
258594001673	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
258594001674	NusA N-terminal domain; Region: NusA_N; pfam08529
258594001675	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
258594001676	RNA binding site [nucleotide binding]; other site
258594001677	homodimer interface [polypeptide binding]; other site
258594001678	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
258594001679	G-X-X-G motif; other site
258594001680	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
258594001681	G-X-X-G motif; other site
258594001682	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
258594001683	ribosome maturation protein RimP; Reviewed; Region: PRK00092
258594001684	Sm and related proteins; Region: Sm_like; cl00259
258594001685	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
258594001686	putative oligomer interface [polypeptide binding]; other site
258594001687	putative RNA binding site [nucleotide binding]; other site
258594001688	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
258594001689	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
258594001690	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
258594001691	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
258594001692	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594001693	non-specific DNA binding site [nucleotide binding]; other site
258594001694	salt bridge; other site
258594001695	sequence-specific DNA binding site [nucleotide binding]; other site
258594001696	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
258594001697	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
258594001698	putative active site [active]
258594001699	catalytic triad [active]
258594001700	putative dimer interface [polypeptide binding]; other site
258594001701	8 probable transmembrane helices predicted byTMHMM2.0
258594001702	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
258594001703	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
258594001704	Transporter associated domain; Region: CorC_HlyC; smart01091
258594001705	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
258594001706	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
258594001707	PhoH-like protein; Region: PhoH; pfam02562
258594001708	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
258594001709	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
258594001710	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594001711	FeS/SAM binding site; other site
258594001712	TRAM domain; Region: TRAM; cl01282
258594001713	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
258594001714	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594001715	motif II; other site
258594001716	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
258594001717	metal binding site 2 [ion binding]; metal-binding site
258594001718	putative DNA binding helix; other site
258594001719	metal binding site 1 [ion binding]; metal-binding site
258594001720	dimer interface [polypeptide binding]; other site
258594001721	structural Zn2+ binding site [ion binding]; other site
258594001722	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
258594001723	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594001724	Coenzyme A binding pocket [chemical binding]; other site
258594001725	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
258594001726	Glycoprotease family; Region: Peptidase_M22; pfam00814
258594001727	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
258594001728	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
258594001729	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
258594001730	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
258594001731	active site
258594001732	HIGH motif; other site
258594001733	dimer interface [polypeptide binding]; other site
258594001734	KMSKS motif; other site
258594001735	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
258594001736	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
258594001737	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
258594001738	13 probable transmembrane helices predicted byTMHMM2.0
258594001739	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
258594001740	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
258594001741	substrate binding site [chemical binding]; other site
258594001742	ATP binding site [chemical binding]; other site
258594001743	AMP-binding domain protein; Validated; Region: PRK08315
258594001744	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
258594001745	acyl-activating enzyme (AAE) consensus motif; other site
258594001746	putative AMP binding site [chemical binding]; other site
258594001747	putative active site [active]
258594001748	putative CoA binding site [chemical binding]; other site
258594001749	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594001750	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
258594001751	Beta-lactamase; Region: Beta-lactamase; pfam00144
258594001752	succinic semialdehyde dehydrogenase; Region: PLN02278
258594001753	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
258594001754	tetramerization interface [polypeptide binding]; other site
258594001755	NAD(P) binding site [chemical binding]; other site
258594001756	catalytic residues [active]
258594001757	enoyl-CoA hydratase; Provisional; Region: PRK12478
258594001758	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594001759	substrate binding site [chemical binding]; other site
258594001760	oxyanion hole (OAH) forming residues; other site
258594001761	trimer interface [polypeptide binding]; other site
258594001762	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594001763	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594001764	AMP-binding domain protein; Validated; Region: PRK08315
258594001765	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594001766	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
258594001767	acyl-activating enzyme (AAE) consensus motif; other site
258594001768	acyl-activating enzyme (AAE) consensus motif; other site
258594001769	putative AMP binding site [chemical binding]; other site
258594001770	putative active site [active]
258594001771	putative CoA binding site [chemical binding]; other site
258594001772	Uncharacterized conserved protein [Function unknown]; Region: COG5361
258594001773	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
258594001774	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
258594001775	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
258594001776	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
258594001777	putative ligand binding site [chemical binding]; other site
258594001778	NAD binding site [chemical binding]; other site
258594001779	catalytic site [active]
258594001780	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
258594001781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
258594001782	7 probable transmembrane helices predicted byTMHMM2.0
258594001783	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
258594001784	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
258594001785	Walker A/P-loop; other site
258594001786	ATP binding site [chemical binding]; other site
258594001787	Q-loop/lid; other site
258594001788	ABC transporter signature motif; other site
258594001789	Walker B; other site
258594001790	D-loop; other site
258594001791	H-loop/switch region; other site
258594001792	NMT1/THI5 like; Region: NMT1; pfam09084
258594001793	Creatinine amidohydrolase; Region: Creatininase; pfam02633
258594001794	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
258594001795	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
258594001796	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
258594001797	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
258594001798	active site
258594001799	FMN binding site [chemical binding]; other site
258594001800	substrate binding site [chemical binding]; other site
258594001801	3Fe-4S cluster binding site [ion binding]; other site
258594001802	2 probable transmembrane helices predicted byTMHMM2.0
258594001803	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
258594001804	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
258594001805	Prostaglandin dehydrogenases; Region: PGDH; cd05288
258594001806	NAD(P) binding site [chemical binding]; other site
258594001807	substrate binding site [chemical binding]; other site
258594001808	dimer interface [polypeptide binding]; other site
258594001809	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
258594001810	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
258594001811	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
258594001812	1 probable transmembrane helix predicted byTMHMM2.0
258594001813	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
258594001814	Predicted membrane protein [Function unknown]; Region: COG2261
258594001815	3 probable transmembrane helices predicted byTMHMM2.0
258594001816	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
258594001817	classical (c) SDRs; Region: SDR_c; cd05233
258594001818	NAD(P) binding site [chemical binding]; other site
258594001819	active site
258594001820	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594001821	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
258594001822	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594001823	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594001824	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594001825	active site
258594001826	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
258594001827	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594001828	substrate binding site [chemical binding]; other site
258594001829	oxyanion hole (OAH) forming residues; other site
258594001830	trimer interface [polypeptide binding]; other site
258594001831	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
258594001832	active site
258594001833	metal binding site [ion binding]; metal-binding site
258594001834	enoyl-CoA hydratase; Provisional; Region: PRK06688
258594001835	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594001836	substrate binding site [chemical binding]; other site
258594001837	oxyanion hole (OAH) forming residues; other site
258594001838	trimer interface [polypeptide binding]; other site
258594001839	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594001840	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
258594001841	putative ligand binding site [chemical binding]; other site
258594001842	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
258594001843	Peptidase family M48; Region: Peptidase_M48; cl12018
258594001844	1 probable transmembrane helix predicted byTMHMM2.0
258594001845	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
258594001846	Ferredoxin [Energy production and conversion]; Region: COG1146
258594001847	4Fe-4S binding domain; Region: Fer4; pfam00037
258594001848	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
258594001849	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
258594001850	RNA binding surface [nucleotide binding]; other site
258594001851	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
258594001852	DEAD/DEAH box helicase; Region: DEAD; pfam00270
258594001853	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
258594001854	nucleotide binding region [chemical binding]; other site
258594001855	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
258594001856	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
258594001857	HAMP domain; Region: HAMP; pfam00672
258594001858	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
258594001859	PAS domain; Region: PAS_9; pfam13426
258594001860	putative active site [active]
258594001861	heme pocket [chemical binding]; other site
258594001862	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
258594001863	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594001864	putative active site [active]
258594001865	heme pocket [chemical binding]; other site
258594001866	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594001867	dimer interface [polypeptide binding]; other site
258594001868	phosphorylation site [posttranslational modification]
258594001869	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594001870	ATP binding site [chemical binding]; other site
258594001871	Mg2+ binding site [ion binding]; other site
258594001872	G-X-G motif; other site
258594001873	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594001874	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594001875	active site
258594001876	phosphorylation site [posttranslational modification]
258594001877	intermolecular recognition site; other site
258594001878	dimerization interface [polypeptide binding]; other site
258594001879	1 probable transmembrane helix predicted byTMHMM2.0
258594001880	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
258594001881	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
258594001882	1 probable transmembrane helix predicted byTMHMM2.0
258594001883	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
258594001884	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
258594001885	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
258594001886	metal ion-dependent adhesion site (MIDAS); other site
258594001887	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594001888	Coenzyme A binding pocket [chemical binding]; other site
258594001889	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
258594001890	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
258594001891	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
258594001892	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
258594001893	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
258594001894	5 probable transmembrane helices predicted byTMHMM2.0
258594001895	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
258594001896	HSP70 interaction site [polypeptide binding]; other site
258594001897	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
258594001898	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
258594001899	Domain of unknown function DUF21; Region: DUF21; pfam01595
258594001900	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
258594001901	Transporter associated domain; Region: CorC_HlyC; smart01091
258594001902	3 probable transmembrane helices predicted byTMHMM2.0
258594001903	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
258594001904	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
258594001905	active site
258594001906	dimer interface [polypeptide binding]; other site
258594001907	metal binding site [ion binding]; metal-binding site
258594001908	shikimate kinase; Provisional; Region: PRK13946
258594001909	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
258594001910	ADP binding site [chemical binding]; other site
258594001911	magnesium binding site [ion binding]; other site
258594001912	putative shikimate binding site; other site
258594001913	1 probable transmembrane helix predicted byTMHMM2.0
258594001914	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
258594001915	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
258594001916	active site
258594001917	DNA binding site [nucleotide binding]
258594001918	Int/Topo IB signature motif; other site
258594001919	IS element
258594001920	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
258594001921	4 probable transmembrane helices predicted byTMHMM2.0
258594001922	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
258594001923	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
258594001924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
258594001925	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
258594001926	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
258594001927	SEC-C motif; Region: SEC-C; pfam02810
258594001928	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
258594001929	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
258594001930	1 probable transmembrane helix predicted byTMHMM2.0
258594001931	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
258594001932	MutS domain I; Region: MutS_I; pfam01624
258594001933	MutS domain II; Region: MutS_II; pfam05188
258594001934	MutS domain III; Region: MutS_III; pfam05192
258594001935	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
258594001936	Walker A/P-loop; other site
258594001937	ATP binding site [chemical binding]; other site
258594001938	Q-loop/lid; other site
258594001939	ABC transporter signature motif; other site
258594001940	Walker B; other site
258594001941	D-loop; other site
258594001942	H-loop/switch region; other site
258594001943	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
258594001944	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
258594001945	dimer interface [polypeptide binding]; other site
258594001946	active site
258594001947	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
258594001948	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594001949	putative substrate translocation pore; other site
258594001950	14 probable transmembrane helices predicted byTMHMM2.0
258594001951	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
258594001952	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594001953	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594001954	1 probable transmembrane helix predicted byTMHMM2.0
258594001955	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
258594001956	MarR family; Region: MarR; pfam01047
258594001957	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
258594001958	metal binding site 2 [ion binding]; metal-binding site
258594001959	putative DNA binding helix; other site
258594001960	metal binding site 1 [ion binding]; metal-binding site
258594001961	dimer interface [polypeptide binding]; other site
258594001962	structural Zn2+ binding site [ion binding]; other site
258594001963	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
258594001964	EamA-like transporter family; Region: EamA; pfam00892
258594001965	EamA-like transporter family; Region: EamA; pfam00892
258594001966	10 probable transmembrane helices predicted byTMHMM2.0
258594001967	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
258594001968	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
258594001969	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
258594001970	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
258594001971	11 probable transmembrane helices predicted byTMHMM2.0
258594001972	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594001973	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594001974	metal binding site [ion binding]; metal-binding site
258594001975	active site
258594001976	I-site; other site
258594001977	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594001978	Sensors of blue-light using FAD; Region: BLUF; pfam04940
258594001979	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
258594001980	5 probable transmembrane helices predicted byTMHMM2.0
258594001981	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
258594001982	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
258594001983	substrate binding pocket [chemical binding]; other site
258594001984	chain length determination region; other site
258594001985	substrate-Mg2+ binding site; other site
258594001986	catalytic residues [active]
258594001987	aspartate-rich region 1; other site
258594001988	active site lid residues [active]
258594001989	aspartate-rich region 2; other site
258594001990	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
258594001991	Transglycosylase; Region: Transgly; cl17702
258594001992	1 probable transmembrane helix predicted byTMHMM2.0
258594001993	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
258594001994	4 probable transmembrane helices predicted byTMHMM2.0
258594001995	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594001996	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594001997	metal binding site [ion binding]; metal-binding site
258594001998	active site
258594001999	I-site; other site
258594002000	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594002001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
258594002002	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
258594002003	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
258594002004	putative acyltransferase; Provisional; Region: PRK05790
258594002005	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
258594002006	dimer interface [polypeptide binding]; other site
258594002007	active site
258594002008	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
258594002009	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
258594002010	NAD(P) binding site [chemical binding]; other site
258594002011	homotetramer interface [polypeptide binding]; other site
258594002012	homodimer interface [polypeptide binding]; other site
258594002013	active site
258594002014	EamA-like transporter family; Region: EamA; pfam00892
258594002015	10 probable transmembrane helices predicted byTMHMM2.0
258594002016	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
258594002017	catalytic motif [active]
258594002018	Catalytic residue [active]
258594002019	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
258594002020	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
258594002021	ATP binding site [chemical binding]; other site
258594002022	putative Mg++ binding site [ion binding]; other site
258594002023	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
258594002024	nucleotide binding region [chemical binding]; other site
258594002025	ATP-binding site [chemical binding]; other site
258594002026	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
258594002027	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
258594002028	Predicted membrane protein [Function unknown]; Region: COG4763
258594002029	Acyltransferase family; Region: Acyl_transf_3; pfam01757
258594002030	10 probable transmembrane helices predicted byTMHMM2.0
258594002031	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
258594002032	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
258594002033	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
258594002034	Porin subfamily; Region: Porin_2; pfam02530
258594002035	Transcriptional regulators [Transcription]; Region: MarR; COG1846
258594002036	MarR family; Region: MarR_2; pfam12802
258594002037	MarR family; Region: MarR_2; cl17246
258594002038	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
258594002039	4 probable transmembrane helices predicted byTMHMM2.0
258594002040	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
258594002041	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
258594002042	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
258594002043	10 probable transmembrane helices predicted byTMHMM2.0
258594002044	LrgA family; Region: LrgA; pfam03788
258594002045	3 probable transmembrane helices predicted byTMHMM2.0
258594002046	LrgB-like family; Region: LrgB; pfam04172
258594002047	7 probable transmembrane helices predicted byTMHMM2.0
258594002048	4 probable transmembrane helices predicted byTMHMM2.0
258594002049	Predicted esterase [General function prediction only]; Region: COG0400
258594002050	putative hydrolase; Provisional; Region: PRK11460
258594002051	Domain of unknown function DUF20; Region: UPF0118; pfam01594
258594002052	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
258594002053	8 probable transmembrane helices predicted byTMHMM2.0
258594002054	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
258594002055	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
258594002056	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
258594002057	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594002058	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
258594002059	DNA binding residues [nucleotide binding]
258594002060	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
258594002061	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594002062	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
258594002063	putative dimerization interface [polypeptide binding]; other site
258594002064	putative substrate binding pocket [chemical binding]; other site
258594002065	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
258594002066	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
258594002067	10 probable transmembrane helices predicted byTMHMM2.0
258594002068	hypothetical protein; Provisional; Region: PRK11171
258594002069	Cupin domain; Region: Cupin_2; pfam07883
258594002070	Cupin domain; Region: Cupin_2; pfam07883
258594002071	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
258594002072	ureidoglycolate hydrolase; Provisional; Region: PRK03606
258594002073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594002074	S-adenosylmethionine binding site [chemical binding]; other site
258594002075	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
258594002076	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
258594002077	active site
258594002078	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
258594002079	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
258594002080	dimer interface [polypeptide binding]; other site
258594002081	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594002082	catalytic residue [active]
258594002083	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
258594002084	ATP binding site [chemical binding]; other site
258594002085	active site
258594002086	substrate binding site [chemical binding]; other site
258594002087	Pirin-related protein [General function prediction only]; Region: COG1741
258594002088	Pirin; Region: Pirin; pfam02678
258594002089	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
258594002090	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
258594002091	PAS domain; Region: PAS_9; pfam13426
258594002092	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
258594002093	putative active site [active]
258594002094	heme pocket [chemical binding]; other site
258594002095	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
258594002096	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
258594002097	5 probable transmembrane helices predicted byTMHMM2.0
258594002098	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
258594002099	4 probable transmembrane helices predicted byTMHMM2.0
258594002100	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
258594002101	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
258594002102	2 probable transmembrane helices predicted byTMHMM2.0
258594002103	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
258594002104	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594002105	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
258594002106	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
258594002107	metal ion-dependent adhesion site (MIDAS); other site
258594002108	Protein of unknown function (DUF1052); Region: DUF1052; pfam06319
258594002109	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
258594002110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594002111	active site
258594002112	phosphorylation site [posttranslational modification]
258594002113	intermolecular recognition site; other site
258594002114	dimerization interface [polypeptide binding]; other site
258594002115	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
258594002116	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594002117	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594002118	dimer interface [polypeptide binding]; other site
258594002119	phosphorylation site [posttranslational modification]
258594002120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594002121	ATP binding site [chemical binding]; other site
258594002122	Mg2+ binding site [ion binding]; other site
258594002123	G-X-G motif; other site
258594002124	5 probable transmembrane helices predicted byTMHMM2.0
258594002125	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
258594002126	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
258594002127	Walker A/P-loop; other site
258594002128	ATP binding site [chemical binding]; other site
258594002129	Q-loop/lid; other site
258594002130	ABC transporter signature motif; other site
258594002131	Walker B; other site
258594002132	D-loop; other site
258594002133	H-loop/switch region; other site
258594002134	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
258594002135	6 probable transmembrane helices predicted byTMHMM2.0
258594002136	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
258594002137	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
258594002138	Protein of unknown function DUF45; Region: DUF45; pfam01863
258594002139	Transglycosylase; Region: Transgly; pfam00912
258594002140	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
258594002141	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
258594002142	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
258594002143	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594002144	putative ligand binding site [chemical binding]; other site
258594002145	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
258594002146	4 probable transmembrane helices predicted byTMHMM2.0
258594002147	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
258594002148	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
258594002149	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
258594002150	putative active site [active]
258594002151	heme pocket [chemical binding]; other site
258594002152	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594002153	dimer interface [polypeptide binding]; other site
258594002154	phosphorylation site [posttranslational modification]
258594002155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594002156	ATP binding site [chemical binding]; other site
258594002157	Mg2+ binding site [ion binding]; other site
258594002158	G-X-G motif; other site
258594002159	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594002160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594002161	active site
258594002162	phosphorylation site [posttranslational modification]
258594002163	intermolecular recognition site; other site
258594002164	dimerization interface [polypeptide binding]; other site
258594002165	1 probable transmembrane helix predicted byTMHMM2.0
258594002166	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
258594002167	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
258594002168	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
258594002169	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
258594002170	RNA binding site [nucleotide binding]; other site
258594002171	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
258594002172	Chromate transporter; Region: Chromate_transp; pfam02417
258594002173	9 probable transmembrane helices predicted byTMHMM2.0
258594002174	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
258594002175	short chain dehydrogenase; Provisional; Region: PRK06197
258594002176	putative NAD(P) binding site [chemical binding]; other site
258594002177	active site
258594002178	amino acid transporter; Region: 2A0306; TIGR00909
258594002179	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
258594002180	13 probable transmembrane helices predicted byTMHMM2.0
258594002181	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594002182	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594002183	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
258594002184	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594002185	active site
258594002186	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
258594002187	C-terminal peptidase (prc); Region: prc; TIGR00225
258594002188	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
258594002189	protein binding site [polypeptide binding]; other site
258594002190	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
258594002191	Catalytic dyad [active]
258594002192	PII uridylyl-transferase; Provisional; Region: PRK05092
258594002193	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
258594002194	metal binding triad; other site
258594002195	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
258594002196	HD domain; Region: HD; pfam01966
258594002197	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
258594002198	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
258594002199	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
258594002200	heterotetramer interface [polypeptide binding]; other site
258594002201	active site pocket [active]
258594002202	cleavage site
258594002203	1 probable transmembrane helix predicted byTMHMM2.0
258594002204	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
258594002205	active site
258594002206	8-oxo-dGMP binding site [chemical binding]; other site
258594002207	nudix motif; other site
258594002208	metal binding site [ion binding]; metal-binding site
258594002209	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
258594002210	Methyltransferase domain; Region: Methyltransf_11; pfam08241
258594002211	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
258594002212	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
258594002213	active site
258594002214	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
258594002215	GSH binding site [chemical binding]; other site
258594002216	catalytic residues [active]
258594002217	nitrilase; Region: PLN02798
258594002218	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
258594002219	putative active site [active]
258594002220	catalytic triad [active]
258594002221	dimer interface [polypeptide binding]; other site
258594002222	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
258594002223	Predicted membrane protein [Function unknown]; Region: COG2510
258594002224	5 probable transmembrane helices predicted byTMHMM2.0
258594002225	10 probable transmembrane helices predicted byTMHMM2.0
258594002226	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
258594002227	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594002228	S-adenosylmethionine binding site [chemical binding]; other site
258594002229	aspartate kinase; Reviewed; Region: PRK06635
258594002230	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
258594002231	putative nucleotide binding site [chemical binding]; other site
258594002232	putative catalytic residues [active]
258594002233	putative Mg ion binding site [ion binding]; other site
258594002234	putative aspartate binding site [chemical binding]; other site
258594002235	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
258594002236	putative allosteric regulatory site; other site
258594002237	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
258594002238	putative allosteric regulatory residue; other site
258594002239	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
258594002240	GAF domain; Region: GAF; pfam01590
258594002241	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
258594002242	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
258594002243	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
258594002244	peptide chain release factor 1; Validated; Region: prfA; PRK00591
258594002245	This domain is found in peptide chain release factors; Region: PCRF; smart00937
258594002246	RF-1 domain; Region: RF-1; pfam00472
258594002247	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
258594002248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594002249	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
258594002250	Methyltransferase domain; Region: Methyltransf_23; pfam13489
258594002251	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594002252	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
258594002253	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
258594002254	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
258594002255	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
258594002256	substrate binding site [chemical binding]; other site
258594002257	ATP binding site [chemical binding]; other site
258594002258	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
258594002259	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
258594002260	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
258594002261	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
258594002262	putative NADH binding site [chemical binding]; other site
258594002263	putative active site [active]
258594002264	nudix motif; other site
258594002265	putative metal binding site [ion binding]; other site
258594002266	HIT domain; Region: HIT; pfam01230
258594002267	nucleotide binding site/active site [active]
258594002268	HIT family signature motif; other site
258594002269	catalytic residue [active]
258594002270	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
258594002271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594002272	Walker A motif; other site
258594002273	ATP binding site [chemical binding]; other site
258594002274	Walker B motif; other site
258594002275	arginine finger; other site
258594002276	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
258594002277	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
258594002278	hypothetical protein; Validated; Region: PRK00153
258594002279	recombination protein RecR; Reviewed; Region: recR; PRK00076
258594002280	RecR protein; Region: RecR; pfam02132
258594002281	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
258594002282	tetramer interface [polypeptide binding]; other site
258594002283	putative active site [active]
258594002284	putative metal-binding site [ion binding]; other site
258594002285	muropeptide transporter; Validated; Region: ampG; cl17669
258594002286	muropeptide transporter; Reviewed; Region: ampG; PRK11902
258594002287	12 probable transmembrane helices predicted byTMHMM2.0
258594002288	RmuC family; Region: RmuC; pfam02646
258594002289	1 probable transmembrane helix predicted byTMHMM2.0
258594002290	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
258594002291	active site
258594002292	catalytic residues [active]
258594002293	metal binding site [ion binding]; metal-binding site
258594002294	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
258594002295	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
258594002296	putative active site [active]
258594002297	substrate binding site [chemical binding]; other site
258594002298	putative cosubstrate binding site; other site
258594002299	catalytic site [active]
258594002300	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
258594002301	substrate binding site [chemical binding]; other site
258594002302	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
258594002303	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
258594002304	dimerization interface 3.5A [polypeptide binding]; other site
258594002305	active site
258594002306	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
258594002307	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
258594002308	metal binding site [ion binding]; metal-binding site
258594002309	dimer interface [polypeptide binding]; other site
258594002310	Predicted membrane protein [Function unknown]; Region: COG3152
258594002311	4 probable transmembrane helices predicted byTMHMM2.0
258594002312	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
258594002313	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
258594002314	trimer interface [polypeptide binding]; other site
258594002315	active site
258594002316	substrate binding site [chemical binding]; other site
258594002317	CoA binding site [chemical binding]; other site
258594002318	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
258594002319	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594002320	motif II; other site
258594002321	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
258594002322	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
258594002323	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
258594002324	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
258594002325	feedback inhibition sensing region; other site
258594002326	homohexameric interface [polypeptide binding]; other site
258594002327	nucleotide binding site [chemical binding]; other site
258594002328	N-acetyl-L-glutamate binding site [chemical binding]; other site
258594002329	4 probable transmembrane helices predicted byTMHMM2.0
258594002330	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
258594002331	G1 box; other site
258594002332	GTP/Mg2+ binding site [chemical binding]; other site
258594002333	Switch I region; other site
258594002334	G2 box; other site
258594002335	G3 box; other site
258594002336	Switch II region; other site
258594002337	G4 box; other site
258594002338	G5 box; other site
258594002339	membrane protein insertase; Provisional; Region: PRK01318
258594002340	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
258594002341	4 probable transmembrane helices predicted byTMHMM2.0
258594002342	Ribonuclease P; Region: Ribonuclease_P; cl00457
258594002343	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
258594002344	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594002345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594002346	ATP binding site [chemical binding]; other site
258594002347	Mg2+ binding site [ion binding]; other site
258594002348	G-X-G motif; other site
258594002349	2 probable transmembrane helices predicted byTMHMM2.0
258594002350	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
258594002351	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
258594002352	RNA polymerase sigma factor; Provisional; Region: PRK12538
258594002353	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594002354	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
258594002355	DNA binding residues [nucleotide binding]
258594002356	flagellin; Provisional; Region: PRK12802
258594002357	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
258594002358	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
258594002359	flagellar capping protein; Reviewed; Region: fliD; PRK08032
258594002360	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
258594002361	Flagellar protein FliS; Region: FliS; cl00654
258594002362	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
258594002363	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
258594002364	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
258594002365	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
258594002366	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
258594002367	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
258594002368	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471
258594002369	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913
258594002370	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
258594002371	enoyl-CoA hydratase; Provisional; Region: PRK05862
258594002372	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594002373	substrate binding site [chemical binding]; other site
258594002374	oxyanion hole (OAH) forming residues; other site
258594002375	trimer interface [polypeptide binding]; other site
258594002376	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
258594002377	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
258594002378	acyl-activating enzyme (AAE) consensus motif; other site
258594002379	putative AMP binding site [chemical binding]; other site
258594002380	putative active site [active]
258594002381	putative CoA binding site [chemical binding]; other site
258594002382	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
258594002383	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594002384	active site
258594002385	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594002386	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
258594002387	substrate binding site [chemical binding]; other site
258594002388	oxyanion hole (OAH) forming residues; other site
258594002389	trimer interface [polypeptide binding]; other site
258594002390	2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206
258594002391	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594002392	NAD(P) binding site [chemical binding]; other site
258594002393	active site
258594002394	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
258594002395	MarR family; Region: MarR_2; pfam12802
258594002396	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
258594002397	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
258594002398	putative NAD(P) binding site [chemical binding]; other site
258594002399	structural Zn binding site [ion binding]; other site
258594002400	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
258594002401	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
258594002402	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
258594002403	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
258594002404	benzoyl-CoA reductase, bcr type, subunit A; Region: benz_CoA_red_A; TIGR02259
258594002405	benzoyl-CoA reductase, bcr type, subunit D; Region: benz_CoA_red_D; TIGR02261
258594002406	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
258594002407	Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959
258594002408	dimer interface [polypeptide binding]; other site
258594002409	acyl-activating enzyme (AAE) consensus motif; other site
258594002410	putative active site [active]
258594002411	putative AMP binding site [chemical binding]; other site
258594002412	putative CoA binding site [chemical binding]; other site
258594002413	chemical substrate binding site [chemical binding]; other site
258594002414	2 probable transmembrane helices predicted byTMHMM2.0
258594002415	archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700
258594002416	Rrf2 family protein; Region: rrf2_super; TIGR00738
258594002417	Transcriptional regulator; Region: Rrf2; pfam02082
258594002418	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594002419	Coenzyme A binding pocket [chemical binding]; other site
258594002420	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594002421	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594002422	Walker A/P-loop; other site
258594002423	ATP binding site [chemical binding]; other site
258594002424	Q-loop/lid; other site
258594002425	ABC transporter signature motif; other site
258594002426	Walker B; other site
258594002427	D-loop; other site
258594002428	H-loop/switch region; other site
258594002429	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594002430	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594002431	TM-ABC transporter signature motif; other site
258594002432	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594002433	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594002434	Walker A/P-loop; other site
258594002435	ATP binding site [chemical binding]; other site
258594002436	Q-loop/lid; other site
258594002437	ABC transporter signature motif; other site
258594002438	Walker B; other site
258594002439	D-loop; other site
258594002440	H-loop/switch region; other site
258594002441	8 probable transmembrane helices predicted byTMHMM2.0
258594002442	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594002443	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594002444	TM-ABC transporter signature motif; other site
258594002445	7 probable transmembrane helices predicted byTMHMM2.0
258594002446	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594002447	Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360
258594002448	putative ligand binding site [chemical binding]; other site
258594002449	1 probable transmembrane helix predicted byTMHMM2.0
258594002450	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
258594002451	Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959
258594002452	dimer interface [polypeptide binding]; other site
258594002453	acyl-activating enzyme (AAE) consensus motif; other site
258594002454	putative active site [active]
258594002455	putative AMP binding site [chemical binding]; other site
258594002456	putative CoA binding site [chemical binding]; other site
258594002457	chemical substrate binding site [chemical binding]; other site
258594002458	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
258594002459	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
258594002460	catalytic loop [active]
258594002461	iron binding site [ion binding]; other site
258594002462	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
258594002463	4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194
258594002464	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
258594002465	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
258594002466	4-hydroxybenzoyl-CoA reductase, beta subunit; Region: 4hydrxCoA_B; TIGR03195
258594002467	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
258594002468	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594002469	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594002470	ligand binding site [chemical binding]; other site
258594002471	flexible hinge region; other site
258594002472	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
258594002473	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
258594002474	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
258594002475	NAD binding site [chemical binding]; other site
258594002476	catalytic Zn binding site [ion binding]; other site
258594002477	substrate binding site [chemical binding]; other site
258594002478	structural Zn binding site [ion binding]; other site
258594002479	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
258594002480	benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184
258594002481	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594002482	substrate binding site [chemical binding]; other site
258594002483	oxyanion hole (OAH) forming residues; other site
258594002484	trimer interface [polypeptide binding]; other site
258594002485	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
258594002486	substrate binding site [chemical binding]; other site
258594002487	trimer interface [polypeptide binding]; other site
258594002488	oxyanion hole (OAH) forming residues; other site
258594002489	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
258594002490	1 probable transmembrane helix predicted byTMHMM2.0
258594002491	putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional; Region: PRK12775
258594002492	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
258594002493	FAD binding pocket [chemical binding]; other site
258594002494	FAD binding motif [chemical binding]; other site
258594002495	phosphate binding motif [ion binding]; other site
258594002496	beta-alpha-beta structure motif; other site
258594002497	NAD binding pocket [chemical binding]; other site
258594002498	Iron coordination center [ion binding]; other site
258594002499	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
258594002500	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
258594002501	diiron binding motif [ion binding]; other site
258594002502	hypothetical protein; Provisional; Region: PRK01254
258594002503	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
258594002504	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
258594002505	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594002506	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594002507	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594002508	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594002509	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
258594002510	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
258594002511	Walker A/P-loop; other site
258594002512	ATP binding site [chemical binding]; other site
258594002513	Q-loop/lid; other site
258594002514	ABC transporter signature motif; other site
258594002515	Walker B; other site
258594002516	D-loop; other site
258594002517	H-loop/switch region; other site
258594002518	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594002519	Walker A/P-loop; other site
258594002520	ATP binding site [chemical binding]; other site
258594002521	Q-loop/lid; other site
258594002522	ABC transporter signature motif; other site
258594002523	Walker B; other site
258594002524	D-loop; other site
258594002525	H-loop/switch region; other site
258594002526	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
258594002527	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
258594002528	6 probable transmembrane helices predicted byTMHMM2.0
258594002529	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
258594002530	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
258594002531	6 probable transmembrane helices predicted byTMHMM2.0
258594002532	Transcriptional regulator [Transcription]; Region: IclR; COG1414
258594002533	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
258594002534	Bacterial transcriptional regulator; Region: IclR; pfam01614
258594002535	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
258594002536	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
258594002537	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
258594002538	active site
258594002539	phosphonate metabolism protein PhnM; Region: phosphono_phnM; TIGR02318
258594002540	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
258594002541	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
258594002542	active site
258594002543	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594002544	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
258594002545	Walker A/P-loop; other site
258594002546	ATP binding site [chemical binding]; other site
258594002547	Q-loop/lid; other site
258594002548	ABC transporter signature motif; other site
258594002549	Walker B; other site
258594002550	D-loop; other site
258594002551	H-loop/switch region; other site
258594002552	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
258594002553	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594002554	Walker A/P-loop; other site
258594002555	ATP binding site [chemical binding]; other site
258594002556	Q-loop/lid; other site
258594002557	ABC transporter signature motif; other site
258594002558	Walker B; other site
258594002559	D-loop; other site
258594002560	H-loop/switch region; other site
258594002561	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
258594002562	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
258594002563	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
258594002564	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845
258594002565	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
258594002566	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
258594002567	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
258594002568	DNA-binding site [nucleotide binding]; DNA binding site
258594002569	UTRA domain; Region: UTRA; pfam07702
258594002570	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
258594002571	6 probable transmembrane helices predicted byTMHMM2.0
258594002572	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
258594002573	4 probable transmembrane helices predicted byTMHMM2.0
258594002574	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
258594002575	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
258594002576	membrane-bound complex binding site; other site
258594002577	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
258594002578	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
258594002579	Walker A/P-loop; other site
258594002580	ATP binding site [chemical binding]; other site
258594002581	Q-loop/lid; other site
258594002582	ABC transporter signature motif; other site
258594002583	Walker B; other site
258594002584	D-loop; other site
258594002585	H-loop/switch region; other site
258594002586	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
258594002587	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
258594002588	trimer interface [polypeptide binding]; other site
258594002589	active site
258594002590	substrate binding site [chemical binding]; other site
258594002591	CoA binding site [chemical binding]; other site
258594002592	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
258594002593	phosphonate metabolism protein PhnM; Region: phosphono_phnM; TIGR02318
258594002594	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
258594002595	active site
258594002596	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
258594002597	1 probable transmembrane helix predicted byTMHMM2.0
258594002598	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
258594002599	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
258594002600	GIY-YIG motif/motif A; other site
258594002601	putative active site [active]
258594002602	putative metal binding site [ion binding]; other site
258594002603	1 probable transmembrane helix predicted byTMHMM2.0
258594002604	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
258594002605	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
258594002606	substrate binding site [chemical binding]; other site
258594002607	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
258594002608	putative FMN binding site [chemical binding]; other site
258594002609	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
258594002610	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
258594002611	putative dimer interface [polypeptide binding]; other site
258594002612	active site pocket [active]
258594002613	putative cataytic base [active]
258594002614	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
258594002615	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
258594002616	homotrimer interface [polypeptide binding]; other site
258594002617	Walker A motif; other site
258594002618	GTP binding site [chemical binding]; other site
258594002619	Walker B motif; other site
258594002620	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
258594002621	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
258594002622	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
258594002623	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
258594002624	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
258594002625	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
258594002626	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
258594002627	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
258594002628	homodimer interface [polypeptide binding]; other site
258594002629	Walker A motif; other site
258594002630	ATP binding site [chemical binding]; other site
258594002631	hydroxycobalamin binding site [chemical binding]; other site
258594002632	Walker B motif; other site
258594002633	cobyric acid synthase; Provisional; Region: PRK00784
258594002634	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
258594002635	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
258594002636	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
258594002637	catalytic triad [active]
258594002638	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
258594002639	5 probable transmembrane helices predicted byTMHMM2.0
258594002640	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
258594002641	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
258594002642	intersubunit interface [polypeptide binding]; other site
258594002643	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
258594002644	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
258594002645	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594002646	homodimer interface [polypeptide binding]; other site
258594002647	catalytic residue [active]
258594002648	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
258594002649	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
258594002650	Walker A/P-loop; other site
258594002651	ATP binding site [chemical binding]; other site
258594002652	Q-loop/lid; other site
258594002653	ABC transporter signature motif; other site
258594002654	Walker B; other site
258594002655	D-loop; other site
258594002656	H-loop/switch region; other site
258594002657	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
258594002658	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
258594002659	ABC-ATPase subunit  interface; other site
258594002660	dimer interface [polypeptide binding]; other site
258594002661	putative PBP binding regions; other site
258594002662	9 probable transmembrane helices predicted byTMHMM2.0
258594002663	High-affinity nickel-transport protein; Region: NicO; cl00964
258594002664	8 probable transmembrane helices predicted byTMHMM2.0
258594002665	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
258594002666	4 probable transmembrane helices predicted byTMHMM2.0
258594002667	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594002668	S-adenosylmethionine binding site [chemical binding]; other site
258594002669	Protein of unknown function (DUF3419); Region: DUF3419; pfam11899
258594002670	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
258594002671	1 probable transmembrane helix predicted byTMHMM2.0
258594002672	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
258594002673	TadE-like protein; Region: TadE; pfam07811
258594002674	2 probable transmembrane helices predicted byTMHMM2.0
258594002675	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
258594002676	TadE-like protein; Region: TadE; pfam07811
258594002677	1 probable transmembrane helix predicted byTMHMM2.0
258594002678	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594002679	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594002680	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
258594002681	dimerization interface [polypeptide binding]; other site
258594002682	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
258594002683	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
258594002684	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
258594002685	putative dimer interface [polypeptide binding]; other site
258594002686	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
258594002687	SLBB domain; Region: SLBB; pfam10531
258594002688	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
258594002689	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
258594002690	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
258594002691	catalytic loop [active]
258594002692	iron binding site [ion binding]; other site
258594002693	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
258594002694	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
258594002695	[4Fe-4S] binding site [ion binding]; other site
258594002696	molybdopterin cofactor binding site; other site
258594002697	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
258594002698	molybdopterin cofactor binding site; other site
258594002699	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
258594002700	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
258594002701	Major Facilitator Superfamily; Region: MFS_1; pfam07690
258594002702	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594002703	13 probable transmembrane helices predicted byTMHMM2.0
258594002704	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
258594002705	Cytochrome c553 [Energy production and conversion]; Region: COG2863
258594002706	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
258594002707	Cytochrome c; Region: Cytochrom_C; cl11414
258594002708	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594002709	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
258594002710	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594002711	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
258594002712	Walker A motif; other site
258594002713	ATP binding site [chemical binding]; other site
258594002714	Walker B motif; other site
258594002715	arginine finger; other site
258594002716	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
258594002717	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
258594002718	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594002719	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
258594002720	acyl-activating enzyme (AAE) consensus motif; other site
258594002721	acyl-activating enzyme (AAE) consensus motif; other site
258594002722	putative AMP binding site [chemical binding]; other site
258594002723	putative active site [active]
258594002724	putative CoA binding site [chemical binding]; other site
258594002725	1 probable transmembrane helix predicted byTMHMM2.0
258594002726	decaheme-associated outer membrane protein, MtrB/PioB family; Region: OMP_MtrB_PioB; TIGR03509
258594002727	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
258594002728	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
258594002729	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
258594002730	1 probable transmembrane helix predicted byTMHMM2.0
258594002731	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
258594002732	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
258594002733	Walker A/P-loop; other site
258594002734	ATP binding site [chemical binding]; other site
258594002735	Q-loop/lid; other site
258594002736	ABC transporter signature motif; other site
258594002737	Walker B; other site
258594002738	D-loop; other site
258594002739	H-loop/switch region; other site
258594002740	TOBE-like domain; Region: TOBE_3; pfam12857
258594002741	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594002742	dimer interface [polypeptide binding]; other site
258594002743	conserved gate region; other site
258594002744	putative PBP binding loops; other site
258594002745	ABC-ATPase subunit interface; other site
258594002746	6 probable transmembrane helices predicted byTMHMM2.0
258594002747	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
258594002748	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594002749	dimer interface [polypeptide binding]; other site
258594002750	conserved gate region; other site
258594002751	putative PBP binding loops; other site
258594002752	ABC-ATPase subunit interface; other site
258594002753	6 probable transmembrane helices predicted byTMHMM2.0
258594002754	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
258594002755	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
258594002756	substrate binding pocket [chemical binding]; other site
258594002757	membrane-bound complex binding site; other site
258594002758	hinge residues; other site
258594002759	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
258594002760	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
258594002761	Active Sites [active]
258594002762	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
258594002763	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
258594002764	Active Sites [active]
258594002765	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
258594002766	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
258594002767	CysD dimerization site [polypeptide binding]; other site
258594002768	G1 box; other site
258594002769	putative GEF interaction site [polypeptide binding]; other site
258594002770	GTP/Mg2+ binding site [chemical binding]; other site
258594002771	Switch I region; other site
258594002772	G2 box; other site
258594002773	G3 box; other site
258594002774	Switch II region; other site
258594002775	G4 box; other site
258594002776	G5 box; other site
258594002777	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
258594002778	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
258594002779	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
258594002780	ligand-binding site [chemical binding]; other site
258594002781	PAS domain S-box; Region: sensory_box; TIGR00229
258594002782	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594002783	putative active site [active]
258594002784	heme pocket [chemical binding]; other site
258594002785	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594002786	PAS fold; Region: PAS_3; pfam08447
258594002787	putative active site [active]
258594002788	heme pocket [chemical binding]; other site
258594002789	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
258594002790	HWE histidine kinase; Region: HWE_HK; smart00911
258594002791	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
258594002792	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594002793	Walker A/P-loop; other site
258594002794	ATP binding site [chemical binding]; other site
258594002795	Q-loop/lid; other site
258594002796	ABC transporter signature motif; other site
258594002797	Walker B; other site
258594002798	D-loop; other site
258594002799	H-loop/switch region; other site
258594002800	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
258594002801	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
258594002802	Amidase; Region: Amidase; pfam01425
258594002803	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
258594002804	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594002805	Walker A/P-loop; other site
258594002806	ATP binding site [chemical binding]; other site
258594002807	Q-loop/lid; other site
258594002808	ABC transporter signature motif; other site
258594002809	Walker B; other site
258594002810	D-loop; other site
258594002811	H-loop/switch region; other site
258594002812	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
258594002813	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
258594002814	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594002815	dimer interface [polypeptide binding]; other site
258594002816	conserved gate region; other site
258594002817	putative PBP binding loops; other site
258594002818	ABC-ATPase subunit interface; other site
258594002819	5 probable transmembrane helices predicted byTMHMM2.0
258594002820	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
258594002821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594002822	dimer interface [polypeptide binding]; other site
258594002823	conserved gate region; other site
258594002824	putative PBP binding loops; other site
258594002825	ABC-ATPase subunit interface; other site
258594002826	6 probable transmembrane helices predicted byTMHMM2.0
258594002827	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
258594002828	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
258594002829	1 probable transmembrane helix predicted byTMHMM2.0
258594002830	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
258594002831	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
258594002832	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594002833	S-adenosylmethionine binding site [chemical binding]; other site
258594002834	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
258594002835	EF-hand domain pair; Region: EF_hand_5; pfam13499
258594002836	Ca2+ binding site [ion binding]; other site
258594002837	1 probable transmembrane helix predicted byTMHMM2.0
258594002838	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
258594002839	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594002840	N-terminal plug; other site
258594002841	ligand-binding site [chemical binding]; other site
258594002842	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594002843	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594002844	ligand binding site [chemical binding]; other site
258594002845	flexible hinge region; other site
258594002846	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
258594002847	putative switch regulator; other site
258594002848	non-specific DNA interactions [nucleotide binding]; other site
258594002849	DNA binding site [nucleotide binding]
258594002850	sequence specific DNA binding site [nucleotide binding]; other site
258594002851	putative cAMP binding site [chemical binding]; other site
258594002852	PAS fold; Region: PAS_3; pfam08447
258594002853	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
258594002854	G4 box; other site
258594002855	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594002856	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594002857	metal binding site [ion binding]; metal-binding site
258594002858	active site
258594002859	I-site; other site
258594002860	Integrase core domain; Region: rve; pfam00665
258594002861	Integrase core domain; Region: rve_3; pfam13683
258594002862	IS element
258594002863	5 probable transmembrane helices predicted byTMHMM2.0
258594002864	ISR1-like IS element
258594002865	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
258594002866	HTH-like domain; Region: HTH_21; pfam13276
258594002867	Integrase core domain; Region: rve; pfam00665
258594002868	Integrase core domain; Region: rve_3; pfam13683
258594002869	Transposase; Region: HTH_Tnp_1; pfam01527
258594002870	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
258594002871	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
258594002872	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
258594002873	1 probable transmembrane helix predicted byTMHMM2.0
258594002874	hypothetical protein; Provisional; Region: PRK11770
258594002875	Domain of unknown function (DUF307); Region: DUF307; pfam03733
258594002876	Domain of unknown function (DUF307); Region: DUF307; pfam03733
258594002877	4 probable transmembrane helices predicted byTMHMM2.0
258594002878	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
258594002879	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
258594002880	PAS fold; Region: PAS_7; pfam12860
258594002881	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594002882	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594002883	metal binding site [ion binding]; metal-binding site
258594002884	active site
258594002885	I-site; other site
258594002886	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594002887	2 probable transmembrane helices predicted byTMHMM2.0
258594002888	2 probable transmembrane helices predicted byTMHMM2.0
258594002889	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594002890	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594002891	active site
258594002892	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
258594002893	Cytochrome c; Region: Cytochrom_C; pfam00034
258594002894	PAS fold; Region: PAS_4; pfam08448
258594002895	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594002896	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594002897	metal binding site [ion binding]; metal-binding site
258594002898	active site
258594002899	I-site; other site
258594002900	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594002901	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594002902	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
258594002903	NAD(P) binding site [chemical binding]; other site
258594002904	active site
258594002905	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
258594002906	Cytochrome P450; Region: p450; cl12078
258594002907	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
258594002908	cyclase homology domain; Region: CHD; cd07302
258594002909	nucleotidyl binding site; other site
258594002910	metal binding site [ion binding]; metal-binding site
258594002911	dimer interface [polypeptide binding]; other site
258594002912	heat shock protein HtpX; Provisional; Region: PRK01345
258594002913	4 probable transmembrane helices predicted byTMHMM2.0
258594002914	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
258594002915	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594002916	14 probable transmembrane helices predicted byTMHMM2.0
258594002917	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
258594002918	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594002919	catalytic residue [active]
258594002920	LssY C-terminus; Region: LssY_C; pfam14067
258594002921	1 probable transmembrane helix predicted byTMHMM2.0
258594002922	Staphylococcal nuclease homologues; Region: SNc; smart00318
258594002923	Catalytic site; other site
258594002924	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
258594002925	Caspase domain; Region: Peptidase_C14; pfam00656
258594002926	1 probable transmembrane helix predicted byTMHMM2.0
258594002927	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
258594002928	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
258594002929	active site
258594002930	zinc binding site [ion binding]; other site
258594002931	Predicted transcriptional regulator [Transcription]; Region: COG2932
258594002932	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
258594002933	Catalytic site [active]
258594002934	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
258594002935	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
258594002936	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
258594002937	quinone interaction residues [chemical binding]; other site
258594002938	active site
258594002939	catalytic residues [active]
258594002940	FMN binding site [chemical binding]; other site
258594002941	substrate binding site [chemical binding]; other site
258594002942	putative hydrolase; Provisional; Region: PRK02113
258594002943	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
258594002944	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
258594002945	active site clefts [active]
258594002946	zinc binding site [ion binding]; other site
258594002947	dimer interface [polypeptide binding]; other site
258594002948	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
258594002949	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
258594002950	11 probable transmembrane helices predicted byTMHMM2.0
258594002951	2 probable transmembrane helices predicted byTMHMM2.0
258594002952	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
258594002953	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
258594002954	active site
258594002955	DNA binding site [nucleotide binding]
258594002956	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
258594002957	DNA binding site [nucleotide binding]
258594002958	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
258594002959	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
258594002960	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
258594002961	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594002962	S-adenosylmethionine binding site [chemical binding]; other site
258594002963	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
258594002964	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
258594002965	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
258594002966	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594002967	putative ligand binding site [chemical binding]; other site
258594002968	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
258594002969	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
258594002970	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
258594002971	putative Mg++ binding site [ion binding]; other site
258594002972	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
258594002973	nucleotide binding region [chemical binding]; other site
258594002974	ATP-binding site [chemical binding]; other site
258594002975	DEAD/H associated; Region: DEAD_assoc; pfam08494
258594002976	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
258594002977	active site
258594002978	metal binding site [ion binding]; metal-binding site
258594002979	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594002980	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594002981	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
258594002982	dimerization interface [polypeptide binding]; other site
258594002983	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
258594002984	EamA-like transporter family; Region: EamA; pfam00892
258594002985	10 probable transmembrane helices predicted byTMHMM2.0
258594002986	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
258594002987	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
258594002988	10 probable transmembrane helices predicted byTMHMM2.0
258594002989	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
258594002990	1 probable transmembrane helix predicted byTMHMM2.0
258594002991	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
258594002992	8 probable transmembrane helices predicted byTMHMM2.0
258594002993	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
258594002994	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594002995	TPR motif; other site
258594002996	binding surface
258594002997	Sel1-like repeats; Region: SEL1; smart00671
258594002998	SnoaL-like domain; Region: SnoaL_2; pfam12680
258594002999	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
258594003000	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
258594003001	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
258594003002	FAD binding site [chemical binding]; other site
258594003003	substrate binding site [chemical binding]; other site
258594003004	catalytic residues [active]
258594003005	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
258594003006	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
258594003007	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
258594003008	dimer interface [polypeptide binding]; other site
258594003009	active site
258594003010	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
258594003011	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594003012	substrate binding site [chemical binding]; other site
258594003013	oxyanion hole (OAH) forming residues; other site
258594003014	trimer interface [polypeptide binding]; other site
258594003015	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
258594003016	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
258594003017	Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406
258594003018	Fanconi anemia ID complex proteins FANCI and FANCD2; Region: FANC; cl17018
258594003019	glutathionine S-transferase; Provisional; Region: PRK10542
258594003020	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
258594003021	C-terminal domain interface [polypeptide binding]; other site
258594003022	GSH binding site (G-site) [chemical binding]; other site
258594003023	dimer interface [polypeptide binding]; other site
258594003024	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
258594003025	dimer interface [polypeptide binding]; other site
258594003026	N-terminal domain interface [polypeptide binding]; other site
258594003027	substrate binding pocket (H-site) [chemical binding]; other site
258594003028	MarR family; Region: MarR_2; pfam12802
258594003029	Transcriptional regulators [Transcription]; Region: MarR; COG1846
258594003030	glutamate--cysteine ligase; Region: PLN02611
258594003031	PAN domain; Region: PAN_4; pfam14295
258594003032	putative binding site; other site
258594003033	PAN domain; Region: PAN_4; pfam14295
258594003034	putative binding site; other site
258594003035	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
258594003036	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
258594003037	Catalytic site [active]
258594003038	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
258594003039	1 probable transmembrane helix predicted byTMHMM2.0
258594003040	protease TldD; Provisional; Region: tldD; PRK10735
258594003041	Protein of unknown function (DUF433); Region: DUF433; pfam04255
258594003042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
258594003043	Transcriptional regulators [Transcription]; Region: MarR; COG1846
258594003044	MarR family; Region: MarR_2; cl17246
258594003045	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
258594003046	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
258594003047	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
258594003048	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
258594003049	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
258594003050	3 probable transmembrane helices predicted byTMHMM2.0
258594003051	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
258594003052	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
258594003053	Subunit I/III interface [polypeptide binding]; other site
258594003054	D-pathway; other site
258594003055	Subunit I/VIIc interface [polypeptide binding]; other site
258594003056	Subunit I/IV interface [polypeptide binding]; other site
258594003057	Subunit I/II interface [polypeptide binding]; other site
258594003058	Low-spin heme (heme a) binding site [chemical binding]; other site
258594003059	Subunit I/VIIa interface [polypeptide binding]; other site
258594003060	Subunit I/VIa interface [polypeptide binding]; other site
258594003061	Dimer interface; other site
258594003062	Putative water exit pathway; other site
258594003063	Binuclear center (heme a3/CuB) [ion binding]; other site
258594003064	K-pathway; other site
258594003065	Subunit I/Vb interface [polypeptide binding]; other site
258594003066	Putative proton exit pathway; other site
258594003067	Subunit I/VIb interface; other site
258594003068	Subunit I/VIc interface [polypeptide binding]; other site
258594003069	Electron transfer pathway; other site
258594003070	Subunit I/VIIIb interface [polypeptide binding]; other site
258594003071	Subunit I/VIIb interface [polypeptide binding]; other site
258594003072	12 probable transmembrane helices predicted byTMHMM2.0
258594003073	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
258594003074	UbiA prenyltransferase family; Region: UbiA; pfam01040
258594003075	9 probable transmembrane helices predicted byTMHMM2.0
258594003076	1 probable transmembrane helix predicted byTMHMM2.0
258594003077	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
258594003078	1 probable transmembrane helix predicted byTMHMM2.0
258594003079	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
258594003080	Subunit III/VIIa interface [polypeptide binding]; other site
258594003081	Phospholipid binding site [chemical binding]; other site
258594003082	Subunit I/III interface [polypeptide binding]; other site
258594003083	Subunit III/VIb interface [polypeptide binding]; other site
258594003084	Subunit III/VIa interface; other site
258594003085	Subunit III/Vb interface [polypeptide binding]; other site
258594003086	7 probable transmembrane helices predicted byTMHMM2.0
258594003087	Protein of unknown function (DUF983); Region: DUF983; cl02211
258594003088	2 probable transmembrane helices predicted byTMHMM2.0
258594003089	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
258594003090	2 probable transmembrane helices predicted byTMHMM2.0
258594003091	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
258594003092	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
258594003093	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594003094	catalytic residue [active]
258594003095	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
258594003096	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
258594003097	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
258594003098	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
258594003099	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
258594003100	1 probable transmembrane helix predicted byTMHMM2.0
258594003101	F0F1 ATP synthase subunit B; Provisional; Region: PRK14475
258594003102	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
258594003103	1 probable transmembrane helix predicted byTMHMM2.0
258594003104	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
258594003105	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
258594003106	1 probable transmembrane helix predicted byTMHMM2.0
258594003107	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
258594003108	2 probable transmembrane helices predicted byTMHMM2.0
258594003109	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
258594003110	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
258594003111	6 probable transmembrane helices predicted byTMHMM2.0
258594003112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
258594003113	2 probable transmembrane helices predicted byTMHMM2.0
258594003114	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
258594003115	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
258594003116	putative catalytic residue [active]
258594003117	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
258594003118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594003119	putative substrate translocation pore; other site
258594003120	12 probable transmembrane helices predicted byTMHMM2.0
258594003121	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
258594003122	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594003123	active site
258594003124	phosphorylation site [posttranslational modification]
258594003125	intermolecular recognition site; other site
258594003126	dimerization interface [polypeptide binding]; other site
258594003127	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
258594003128	DNA binding residues [nucleotide binding]
258594003129	dimerization interface [polypeptide binding]; other site
258594003130	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
258594003131	Na binding site [ion binding]; other site
258594003132	PAS fold; Region: PAS_7; pfam12860
258594003133	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594003134	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594003135	dimer interface [polypeptide binding]; other site
258594003136	phosphorylation site [posttranslational modification]
258594003137	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594003138	ATP binding site [chemical binding]; other site
258594003139	Mg2+ binding site [ion binding]; other site
258594003140	G-X-G motif; other site
258594003141	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594003142	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594003143	active site
258594003144	phosphorylation site [posttranslational modification]
258594003145	intermolecular recognition site; other site
258594003146	dimerization interface [polypeptide binding]; other site
258594003147	12 probable transmembrane helices predicted byTMHMM2.0
258594003148	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
258594003149	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
258594003150	substrate-cofactor binding pocket; other site
258594003151	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594003152	catalytic residue [active]
258594003153	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
258594003154	HAMP domain; Region: HAMP; pfam00672
258594003155	dimerization interface [polypeptide binding]; other site
258594003156	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
258594003157	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594003158	dimer interface [polypeptide binding]; other site
258594003159	putative CheW interface [polypeptide binding]; other site
258594003160	1 probable transmembrane helix predicted byTMHMM2.0
258594003161	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
258594003162	1 probable transmembrane helix predicted byTMHMM2.0
258594003163	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
258594003164	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
258594003165	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
258594003166	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
258594003167	ABC-ATPase subunit  interface; other site
258594003168	dimer interface [polypeptide binding]; other site
258594003169	putative PBP binding regions; other site
258594003170	8 probable transmembrane helices predicted byTMHMM2.0
258594003171	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
258594003172	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
258594003173	metal binding site [ion binding]; metal-binding site
258594003174	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
258594003175	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
258594003176	P-loop, Walker A motif; other site
258594003177	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
258594003178	Base recognition motif; other site
258594003179	G4 box; other site
258594003180	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
258594003181	FOG: WD40 repeat [General function prediction only]; Region: COG2319
258594003182	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
258594003183	structural tetrad; other site
258594003184	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
258594003185	MgtC family; Region: MgtC; pfam02308
258594003186	4 probable transmembrane helices predicted byTMHMM2.0
258594003187	1 probable transmembrane helix predicted byTMHMM2.0
258594003188	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
258594003189	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
258594003190	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
258594003191	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
258594003192	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
258594003193	homotrimer interaction site [polypeptide binding]; other site
258594003194	putative active site [active]
258594003195	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594003196	Coenzyme A binding pocket [chemical binding]; other site
258594003197	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
258594003198	dimer interface [polypeptide binding]; other site
258594003199	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
258594003200	active site
258594003201	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
258594003202	catalytic residues [active]
258594003203	substrate binding site [chemical binding]; other site
258594003204	2 probable transmembrane helices predicted byTMHMM2.0
258594003205	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
258594003206	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
258594003207	active site
258594003208	Zn binding site [ion binding]; other site
258594003209	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
258594003210	High-affinity nickel-transport protein; Region: NicO; cl00964
258594003211	High-affinity nickel-transport protein; Region: NicO; cl00964
258594003212	7 probable transmembrane helices predicted byTMHMM2.0
258594003213	ferrochelatase; Reviewed; Region: hemH; PRK00035
258594003214	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
258594003215	C-terminal domain interface [polypeptide binding]; other site
258594003216	active site
258594003217	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
258594003218	active site
258594003219	N-terminal domain interface [polypeptide binding]; other site
258594003220	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
258594003221	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
258594003222	1 probable transmembrane helix predicted byTMHMM2.0
258594003223	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
258594003224	3 probable transmembrane helices predicted byTMHMM2.0
258594003225	Helix-turn-helix domain; Region: HTH_18; pfam12833
258594003226	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594003227	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
258594003228	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
258594003229	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
258594003230	putative active site [active]
258594003231	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
258594003232	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
258594003233	8 probable transmembrane helices predicted byTMHMM2.0
258594003234	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
258594003235	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594003236	dimer interface [polypeptide binding]; other site
258594003237	conserved gate region; other site
258594003238	putative PBP binding loops; other site
258594003239	ABC-ATPase subunit interface; other site
258594003240	5 probable transmembrane helices predicted byTMHMM2.0
258594003241	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
258594003242	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
258594003243	Walker A/P-loop; other site
258594003244	ATP binding site [chemical binding]; other site
258594003245	Q-loop/lid; other site
258594003246	ABC transporter signature motif; other site
258594003247	Walker B; other site
258594003248	D-loop; other site
258594003249	H-loop/switch region; other site
258594003250	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
258594003251	NMT1/THI5 like; Region: NMT1; pfam09084
258594003252	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594003253	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594003254	metal binding site [ion binding]; metal-binding site
258594003255	active site
258594003256	I-site; other site
258594003257	2 probable transmembrane helices predicted byTMHMM2.0
258594003258	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
258594003259	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
258594003260	active site
258594003261	tetramer interface; other site
258594003262	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
258594003263	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
258594003264	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
258594003265	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
258594003266	putative dimer interface [polypeptide binding]; other site
258594003267	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
258594003268	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
258594003269	active site
258594003270	dimer interface [polypeptide binding]; other site
258594003271	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
258594003272	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
258594003273	active site
258594003274	FMN binding site [chemical binding]; other site
258594003275	substrate binding site [chemical binding]; other site
258594003276	3Fe-4S cluster binding site [ion binding]; other site
258594003277	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
258594003278	domain interface; other site
258594003279	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
258594003280	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
258594003281	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
258594003282	putative active site [active]
258594003283	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
258594003284	Transposase; Region: DEDD_Tnp_IS110; pfam01548
258594003285	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
258594003286	IS element
258594003287	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
258594003288	classical (c) SDRs; Region: SDR_c; cd05233
258594003289	NAD(P) binding site [chemical binding]; other site
258594003290	active site
258594003291	classical (c) SDRs; Region: SDR_c; cd05233
258594003292	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
258594003293	NAD(P) binding site [chemical binding]; other site
258594003294	active site
258594003295	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
258594003296	active site
258594003297	oxyanion hole [active]
258594003298	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
258594003299	catalytic triad [active]
258594003300	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
258594003301	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
258594003302	dimer interface [polypeptide binding]; other site
258594003303	active site
258594003304	catalytic residue [active]
258594003305	Transglycosylase SLT domain; Region: SLT_2; pfam13406
258594003306	murein hydrolase B; Provisional; Region: PRK10760; cl17906
258594003307	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
258594003308	1 probable transmembrane helix predicted byTMHMM2.0
258594003309	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
258594003310	6 probable transmembrane helices predicted byTMHMM2.0
258594003311	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
258594003312	8 probable transmembrane helices predicted byTMHMM2.0
258594003313	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
258594003314	putative dimer interface [polypeptide binding]; other site
258594003315	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
258594003316	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594003317	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
258594003318	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
258594003319	active site
258594003320	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
258594003321	1 probable transmembrane helix predicted byTMHMM2.0
258594003322	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
258594003323	Response regulator receiver domain; Region: Response_reg; pfam00072
258594003324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594003325	active site
258594003326	phosphorylation site [posttranslational modification]
258594003327	intermolecular recognition site; other site
258594003328	dimerization interface [polypeptide binding]; other site
258594003329	1 probable transmembrane helix predicted byTMHMM2.0
258594003330	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
258594003331	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
258594003332	Pirin-related protein [General function prediction only]; Region: COG1741
258594003333	Pirin; Region: Pirin; pfam02678
258594003334	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594003335	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594003336	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
258594003337	putative effector binding pocket; other site
258594003338	dimerization interface [polypeptide binding]; other site
258594003339	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
258594003340	hypothetical protein; Validated; Region: PRK00228
258594003341	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
258594003342	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
258594003343	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
258594003344	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594003345	PAS fold; Region: PAS_3; pfam08447
258594003346	putative active site [active]
258594003347	heme pocket [chemical binding]; other site
258594003348	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594003349	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594003350	metal binding site [ion binding]; metal-binding site
258594003351	active site
258594003352	I-site; other site
258594003353	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594003354	7 probable transmembrane helices predicted byTMHMM2.0
258594003355	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
258594003356	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
258594003357	NAD(P) binding site [chemical binding]; other site
258594003358	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
258594003359	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
258594003360	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
258594003361	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
258594003362	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
258594003363	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594003364	Walker A/P-loop; other site
258594003365	ATP binding site [chemical binding]; other site
258594003366	Q-loop/lid; other site
258594003367	ABC transporter signature motif; other site
258594003368	Walker B; other site
258594003369	D-loop; other site
258594003370	H-loop/switch region; other site
258594003371	5 probable transmembrane helices predicted byTMHMM2.0
258594003372	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
258594003373	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594003374	Coenzyme A binding pocket [chemical binding]; other site
258594003375	hypothetical protein; Validated; Region: PRK09039
258594003376	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
258594003377	ligand binding site [chemical binding]; other site
258594003378	1 probable transmembrane helix predicted byTMHMM2.0
258594003379	4 probable transmembrane helices predicted byTMHMM2.0
258594003380	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
258594003381	6 probable transmembrane helices predicted byTMHMM2.0
258594003382	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
258594003383	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594003384	S-adenosylmethionine binding site [chemical binding]; other site
258594003385	1 probable transmembrane helix predicted byTMHMM2.0
258594003386	1 probable transmembrane helix predicted byTMHMM2.0
258594003387	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594003388	salt bridge; other site
258594003389	non-specific DNA binding site [nucleotide binding]; other site
258594003390	sequence-specific DNA binding site [nucleotide binding]; other site
258594003391	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
258594003392	4 probable transmembrane helices predicted byTMHMM2.0
258594003393	1 probable transmembrane helix predicted byTMHMM2.0
258594003394	Flavoprotein; Region: Flavoprotein; pfam02441
258594003395	polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421
258594003396	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
258594003397	SCP-2 sterol transfer family; Region: SCP2; cl01225
258594003398	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
258594003399	Peptidase family U32; Region: Peptidase_U32; pfam01136
258594003400	putative protease; Provisional; Region: PRK15447
258594003401	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
258594003402	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
258594003403	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
258594003404	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594003405	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594003406	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
258594003407	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
258594003408	active site
258594003409	dimerization interface [polypeptide binding]; other site
258594003410	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
258594003411	Sel1-like repeats; Region: SEL1; smart00671
258594003412	Sel1-like repeats; Region: SEL1; smart00671
258594003413	Sel1-like repeats; Region: SEL1; smart00671
258594003414	1 probable transmembrane helix predicted byTMHMM2.0
258594003415	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
258594003416	active site
258594003417	thiamine phosphate binding site [chemical binding]; other site
258594003418	pyrophosphate binding site [ion binding]; other site
258594003419	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
258594003420	active site
258594003421	intersubunit interface [polypeptide binding]; other site
258594003422	catalytic residue [active]
258594003423	PemK-like protein; Region: PemK; pfam02452
258594003424	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
258594003425	Phosphoglycerate kinase; Region: PGK; pfam00162
258594003426	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
258594003427	substrate binding site [chemical binding]; other site
258594003428	hinge regions; other site
258594003429	ADP binding site [chemical binding]; other site
258594003430	catalytic site [active]
258594003431	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
258594003432	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
258594003433	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
258594003434	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
258594003435	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
258594003436	TPP-binding site [chemical binding]; other site
258594003437	dimer interface [polypeptide binding]; other site
258594003438	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
258594003439	PYR/PP interface [polypeptide binding]; other site
258594003440	dimer interface [polypeptide binding]; other site
258594003441	TPP binding site [chemical binding]; other site
258594003442	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
258594003443	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
258594003444	Cell division protein ZapA; Region: ZapA; pfam05164
258594003445	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
258594003446	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594003447	S-adenosylmethionine binding site [chemical binding]; other site
258594003448	multidrug efflux protein; Reviewed; Region: PRK01766
258594003449	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
258594003450	cation binding site [ion binding]; other site
258594003451	12 probable transmembrane helices predicted byTMHMM2.0
258594003452	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
258594003453	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
258594003454	RNA binding surface [nucleotide binding]; other site
258594003455	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
258594003456	Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613
258594003457	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
258594003458	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
258594003459	TPP-binding site; other site
258594003460	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
258594003461	PYR/PP interface [polypeptide binding]; other site
258594003462	dimer interface [polypeptide binding]; other site
258594003463	TPP binding site [chemical binding]; other site
258594003464	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
258594003465	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
258594003466	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
258594003467	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
258594003468	putative active site [active]
258594003469	Zn binding site [ion binding]; other site
258594003470	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
258594003471	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
258594003472	putative active site [active]
258594003473	putative metal binding site [ion binding]; other site
258594003474	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
258594003475	1 probable transmembrane helix predicted byTMHMM2.0
258594003476	enoyl-CoA hydratase; Provisional; Region: PRK06688
258594003477	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594003478	substrate binding site [chemical binding]; other site
258594003479	oxyanion hole (OAH) forming residues; other site
258594003480	trimer interface [polypeptide binding]; other site
258594003481	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594003482	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594003483	active site
258594003484	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
258594003485	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
258594003486	uptake hydrogenase regulatory protein hupV pseudogene, frameshifted
258594003487	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
258594003488	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
258594003489	1 probable transmembrane helix predicted byTMHMM2.0
258594003490	hydrogenase 1 large subunit; Provisional; Region: PRK10170
258594003491	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
258594003492	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
258594003493	4 probable transmembrane helices predicted byTMHMM2.0
258594003494	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
258594003495	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
258594003496	putative substrate-binding site; other site
258594003497	nickel binding site [ion binding]; other site
258594003498	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
258594003499	7 probable transmembrane helices predicted byTMHMM2.0
258594003500	HupF/HypC family; Region: HupF_HypC; pfam01455
258594003501	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
258594003502	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
258594003503	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
258594003504	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
258594003505	Rubredoxin; Region: Rubredoxin; pfam00301
258594003506	iron binding site [ion binding]; other site
258594003507	Protein of unknown function (DUF3457); Region: DUF3457; pfam11939
258594003508	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
258594003509	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
258594003510	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
258594003511	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
258594003512	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
258594003513	Acylphosphatase; Region: Acylphosphatase; pfam00708
258594003514	HypF finger; Region: zf-HYPF; pfam07503
258594003515	HypF finger; Region: zf-HYPF; pfam07503
258594003516	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
258594003517	HupF/HypC family; Region: HupF_HypC; pfam01455
258594003518	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
258594003519	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
258594003520	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
258594003521	dimerization interface [polypeptide binding]; other site
258594003522	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
258594003523	ATP binding site [chemical binding]; other site
258594003524	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
258594003525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594003526	active site
258594003527	phosphorylation site [posttranslational modification]
258594003528	intermolecular recognition site; other site
258594003529	dimerization interface [polypeptide binding]; other site
258594003530	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594003531	Walker A motif; other site
258594003532	ATP binding site [chemical binding]; other site
258594003533	Walker B motif; other site
258594003534	arginine finger; other site
258594003535	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
258594003536	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
258594003537	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594003538	putative active site [active]
258594003539	heme pocket [chemical binding]; other site
258594003540	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594003541	dimer interface [polypeptide binding]; other site
258594003542	phosphorylation site [posttranslational modification]
258594003543	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594003544	ATP binding site [chemical binding]; other site
258594003545	Mg2+ binding site [ion binding]; other site
258594003546	G-X-G motif; other site
258594003547	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594003548	PAS fold; Region: PAS_3; pfam08447
258594003549	putative active site [active]
258594003550	heme pocket [chemical binding]; other site
258594003551	PAS domain S-box; Region: sensory_box; TIGR00229
258594003552	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594003553	putative active site [active]
258594003554	heme pocket [chemical binding]; other site
258594003555	PAS domain S-box; Region: sensory_box; TIGR00229
258594003556	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594003557	dimer interface [polypeptide binding]; other site
258594003558	phosphorylation site [posttranslational modification]
258594003559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594003560	ATP binding site [chemical binding]; other site
258594003561	Mg2+ binding site [ion binding]; other site
258594003562	G-X-G motif; other site
258594003563	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594003564	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594003565	active site
258594003566	phosphorylation site [posttranslational modification]
258594003567	intermolecular recognition site; other site
258594003568	dimerization interface [polypeptide binding]; other site
258594003569	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
258594003570	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
258594003571	Bacterial transcriptional regulator; Region: IclR; pfam01614
258594003572	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
258594003573	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
258594003574	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
258594003575	alpha subunit interface [polypeptide binding]; other site
258594003576	active site
258594003577	substrate binding site [chemical binding]; other site
258594003578	Fe binding site [ion binding]; other site
258594003579	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
258594003580	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
258594003581	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
258594003582	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594003583	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
258594003584	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594003585	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594003586	TM-ABC transporter signature motif; other site
258594003587	8 probable transmembrane helices predicted byTMHMM2.0
258594003588	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594003589	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594003590	TM-ABC transporter signature motif; other site
258594003591	8 probable transmembrane helices predicted byTMHMM2.0
258594003592	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594003593	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594003594	Walker A/P-loop; other site
258594003595	ATP binding site [chemical binding]; other site
258594003596	Q-loop/lid; other site
258594003597	ABC transporter signature motif; other site
258594003598	Walker B; other site
258594003599	D-loop; other site
258594003600	H-loop/switch region; other site
258594003601	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594003602	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594003603	Walker A/P-loop; other site
258594003604	ATP binding site [chemical binding]; other site
258594003605	Q-loop/lid; other site
258594003606	ABC transporter signature motif; other site
258594003607	Walker B; other site
258594003608	D-loop; other site
258594003609	H-loop/switch region; other site
258594003610	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
258594003611	GAF domain; Region: GAF; pfam01590
258594003612	Phytochrome region; Region: PHY; pfam00360
258594003613	HWE histidine kinase; Region: HWE_HK; pfam07536
258594003614	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594003615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594003616	active site
258594003617	phosphorylation site [posttranslational modification]
258594003618	intermolecular recognition site; other site
258594003619	dimerization interface [polypeptide binding]; other site
258594003620	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594003621	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
258594003622	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
258594003623	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594003624	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594003625	ligand binding site [chemical binding]; other site
258594003626	flexible hinge region; other site
258594003627	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
258594003628	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
258594003629	catalytic core [active]
258594003630	Cysteine-rich small domain; Region: zf-like; cl00946
258594003631	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594003632	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594003633	active site
258594003634	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
258594003635	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
258594003636	PGAP1-like protein; Region: PGAP1; pfam07819
258594003637	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594003638	dimerization interface [polypeptide binding]; other site
258594003639	putative DNA binding site [nucleotide binding]; other site
258594003640	putative Zn2+ binding site [ion binding]; other site
258594003641	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
258594003642	active site residue [active]
258594003643	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594003644	S-adenosylmethionine binding site [chemical binding]; other site
258594003645	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
258594003646	putative catalytic residues [active]
258594003647	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
258594003648	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
258594003649	molybdenum transport protein ModD; Provisional; Region: PRK06096
258594003650	dimerization interface [polypeptide binding]; other site
258594003651	active site
258594003652	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
258594003653	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594003654	acyl-activating enzyme (AAE) consensus motif; other site
258594003655	AMP binding site [chemical binding]; other site
258594003656	active site
258594003657	CoA binding site [chemical binding]; other site
258594003658	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
258594003659	active site
258594003660	Ap6A binding site [chemical binding]; other site
258594003661	nudix motif; other site
258594003662	metal binding site [ion binding]; metal-binding site
258594003663	The A subunit of Uncharacterized proteins with similarity to Protocatechuate 4,5-dioxygenase (LigAB); Region: LigA_like_1; cd07925
258594003664	putative dimer interface [polypeptide binding]; other site
258594003665	putative tetramer interface [polypeptide binding]; other site
258594003666	putative active site [active]
258594003667	The B subunit of unknown Class III extradiol dioxygenases with similarity to Protocatechuate 4,5-dioxygenase; Region: PCA_45_Doxase_B_like_1; cd07949
258594003668	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
258594003669	putative active site [active]
258594003670	Fe(II) binding site [ion binding]; other site
258594003671	putative dimer interface [polypeptide binding]; other site
258594003672	putative tetramer interface [polypeptide binding]; other site
258594003673	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
258594003674	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594003675	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
258594003676	Cytochrome P450; Region: p450; cl12078
258594003677	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
258594003678	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
258594003679	SCP-2 sterol transfer family; Region: SCP2; pfam02036
258594003680	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
258594003681	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
258594003682	putative catalytic residue [active]
258594003683	Predicted permeases [General function prediction only]; Region: COG0730
258594003684	8 probable transmembrane helices predicted byTMHMM2.0
258594003685	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
258594003686	4Fe-4S binding domain; Region: Fer4_5; pfam12801
258594003687	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
258594003688	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
258594003689	5 probable transmembrane helices predicted byTMHMM2.0
258594003690	2 probable transmembrane helices predicted byTMHMM2.0
258594003691	Predicted transcriptional regulators [Transcription]; Region: COG1695
258594003692	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
258594003693	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
258594003694	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
258594003695	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
258594003696	[2Fe-2S] cluster binding site [ion binding]; other site
258594003697	1 probable transmembrane helix predicted byTMHMM2.0
258594003698	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cd00562
258594003699	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
258594003700	2 probable transmembrane helices predicted byTMHMM2.0
258594003701	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594003702	dimerization interface [polypeptide binding]; other site
258594003703	putative DNA binding site [nucleotide binding]; other site
258594003704	putative Zn2+ binding site [ion binding]; other site
258594003705	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594003706	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
258594003707	E3 interaction surface; other site
258594003708	lipoyl attachment site [posttranslational modification]; other site
258594003709	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594003710	1 probable transmembrane helix predicted byTMHMM2.0
258594003711	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
258594003712	Protein export membrane protein; Region: SecD_SecF; cl14618
258594003713	12 probable transmembrane helices predicted byTMHMM2.0
258594003714	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
258594003715	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
258594003716	catalytic residues [active]
258594003717	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
258594003718	FAD binding pocket [chemical binding]; other site
258594003719	FAD binding motif [chemical binding]; other site
258594003720	phosphate binding motif [ion binding]; other site
258594003721	beta-alpha-beta structure motif; other site
258594003722	NAD binding pocket [chemical binding]; other site
258594003723	7 probable transmembrane helices predicted byTMHMM2.0
258594003724	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173
258594003725	1 probable transmembrane helix predicted byTMHMM2.0
258594003726	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
258594003727	DNA methylase; Region: N6_N4_Mtase; pfam01555
258594003728	Predicted metalloprotease [General function prediction only]; Region: COG2321
258594003729	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
258594003730	1 probable transmembrane helix predicted byTMHMM2.0
258594003731	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
258594003732	MPT binding site; other site
258594003733	trimer interface [polypeptide binding]; other site
258594003734	Coenzyme A transferase; Region: CoA_trans; smart00882
258594003735	Coenzyme A transferase; Region: CoA_trans; cl17247
258594003736	Transcriptional regulators [Transcription]; Region: MarR; COG1846
258594003737	MarR family; Region: MarR; pfam01047
258594003738	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594003739	Coenzyme A binding pocket [chemical binding]; other site
258594003740	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
258594003741	active site
258594003742	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
258594003743	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594003744	FeS/SAM binding site; other site
258594003745	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
258594003746	RNA/DNA hybrid binding site [nucleotide binding]; other site
258594003747	active site
258594003748	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
258594003749	9 probable transmembrane helices predicted byTMHMM2.0
258594003750	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
258594003751	Fe-S cluster binding site [ion binding]; other site
258594003752	active site
258594003753	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
258594003754	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
258594003755	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
258594003756	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
258594003757	binding surface
258594003758	TPR motif; other site
258594003759	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594003760	binding surface
258594003761	TPR motif; other site
258594003762	TPR repeat; Region: TPR_11; pfam13414
258594003763	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594003764	binding surface
258594003765	TPR motif; other site
258594003766	TPR repeat; Region: TPR_11; pfam13414
258594003767	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
258594003768	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
258594003769	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
258594003770	substrate binding pocket [chemical binding]; other site
258594003771	chain length determination region; other site
258594003772	substrate-Mg2+ binding site; other site
258594003773	catalytic residues [active]
258594003774	aspartate-rich region 1; other site
258594003775	active site lid residues [active]
258594003776	aspartate-rich region 2; other site
258594003777	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
258594003778	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
258594003779	Methyltransferase domain; Region: Methyltransf_26; pfam13659
258594003780	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
258594003781	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
258594003782	tandem repeat interface [polypeptide binding]; other site
258594003783	oligomer interface [polypeptide binding]; other site
258594003784	active site residues [active]
258594003785	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
258594003786	dimer interface [polypeptide binding]; other site
258594003787	motif 1; other site
258594003788	active site
258594003789	motif 2; other site
258594003790	motif 3; other site
258594003791	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
258594003792	putative active site [active]
258594003793	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
258594003794	Predicted membrane protein [Function unknown]; Region: COG3174
258594003795	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
258594003796	14 probable transmembrane helices predicted byTMHMM2.0
258594003797	2 probable transmembrane helices predicted byTMHMM2.0
258594003798	pyruvate phosphate dikinase; Provisional; Region: PRK09279
258594003799	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
258594003800	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
258594003801	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
258594003802	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
258594003803	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
258594003804	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
258594003805	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
258594003806	dimerization interface [polypeptide binding]; other site
258594003807	active site
258594003808	L-aspartate oxidase; Provisional; Region: PRK07512
258594003809	L-aspartate oxidase; Provisional; Region: PRK06175
258594003810	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
258594003811	quinolinate synthetase; Provisional; Region: PRK09375
258594003812	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
258594003813	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
258594003814	NADP binding site [chemical binding]; other site
258594003815	dimer interface [polypeptide binding]; other site
258594003816	1 probable transmembrane helix predicted byTMHMM2.0
258594003817	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
258594003818	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594003819	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
258594003820	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594003821	N-terminal plug; other site
258594003822	ligand-binding site [chemical binding]; other site
258594003823	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
258594003824	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
258594003825	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
258594003826	25 probable transmembrane helices predicted byTMHMM2.0
258594003827	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
258594003828	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
258594003829	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
258594003830	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
258594003831	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
258594003832	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
258594003833	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
258594003834	dihydroorotase; Validated; Region: PRK09060
258594003835	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
258594003836	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
258594003837	active site
258594003838	Protein of unknown function (DUF2385); Region: DUF2385; pfam09539
258594003839	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
258594003840	nudix motif; other site
258594003841	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
258594003842	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
258594003843	FAD binding domain; Region: FAD_binding_4; pfam01565
258594003844	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
258594003845	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
258594003846	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594003847	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
258594003848	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594003849	benzoate transport; Region: 2A0115; TIGR00895
258594003850	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594003851	putative substrate translocation pore; other site
258594003852	12 probable transmembrane helices predicted byTMHMM2.0
258594003853	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
258594003854	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
258594003855	active site
258594003856	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
258594003857	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
258594003858	1 probable transmembrane helix predicted byTMHMM2.0
258594003859	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; pfam10614
258594003860	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
258594003861	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
258594003862	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
258594003863	N-acetyl-D-glucosamine binding site [chemical binding]; other site
258594003864	catalytic residue [active]
258594003865	1 probable transmembrane helix predicted byTMHMM2.0
258594003866	2 probable transmembrane helices predicted byTMHMM2.0
258594003867	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
258594003868	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594003869	ligand binding site [chemical binding]; other site
258594003870	flexible hinge region; other site
258594003871	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
258594003872	non-specific DNA interactions [nucleotide binding]; other site
258594003873	DNA binding site [nucleotide binding]
258594003874	sequence specific DNA binding site [nucleotide binding]; other site
258594003875	putative cAMP binding site [chemical binding]; other site
258594003876	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
258594003877	2 probable transmembrane helices predicted byTMHMM2.0
258594003878	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
258594003879	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
258594003880	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
258594003881	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
258594003882	dimerization interface [polypeptide binding]; other site
258594003883	active site
258594003884	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
258594003885	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594003886	FAD binding site [chemical binding]; other site
258594003887	substrate binding pocket [chemical binding]; other site
258594003888	catalytic base [active]
258594003889	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
258594003890	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594003891	dimer interface [polypeptide binding]; other site
258594003892	putative CheW interface [polypeptide binding]; other site
258594003893	hypothetical protein; Validated; Region: PRK00110
258594003894	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
258594003895	active site
258594003896	putative DNA-binding cleft [nucleotide binding]; other site
258594003897	dimer interface [polypeptide binding]; other site
258594003898	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
258594003899	RuvA N terminal domain; Region: RuvA_N; pfam01330
258594003900	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
258594003901	active site
258594003902	catalytic motif [active]
258594003903	Zn binding site [ion binding]; other site
258594003904	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
258594003905	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594003906	Walker A motif; other site
258594003907	ATP binding site [chemical binding]; other site
258594003908	Walker B motif; other site
258594003909	arginine finger; other site
258594003910	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
258594003911	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
258594003912	active site
258594003913	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
258594003914	OpgC protein; Region: OpgC_C; pfam10129
258594003915	Acyltransferase family; Region: Acyl_transf_3; pfam01757
258594003916	10 probable transmembrane helices predicted byTMHMM2.0
258594003917	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
258594003918	SnoaL-like domain; Region: SnoaL_2; pfam12680
258594003919	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594003920	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594003921	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
258594003922	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
258594003923	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594003924	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
258594003925	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
258594003926	classical (c) SDRs; Region: SDR_c; cd05233
258594003927	NAD(P) binding site [chemical binding]; other site
258594003928	active site
258594003929	1 probable transmembrane helix predicted byTMHMM2.0
258594003930	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
258594003931	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594003932	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594003933	WHG domain; Region: WHG; pfam13305
258594003934	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
258594003935	1 probable transmembrane helix predicted byTMHMM2.0
258594003936	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
258594003937	Uncharacterized conserved protein [Function unknown]; Region: COG2128
258594003938	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
258594003939	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594003940	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
258594003941	TolQ protein; Region: tolQ; TIGR02796
258594003942	3 probable transmembrane helices predicted byTMHMM2.0
258594003943	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
258594003944	TolR protein; Region: tolR; TIGR02801
258594003945	1 probable transmembrane helix predicted byTMHMM2.0
258594003946	1 probable transmembrane helix predicted byTMHMM2.0
258594003947	translocation protein TolB; Provisional; Region: tolB; PRK05137
258594003948	TolB amino-terminal domain; Region: TolB_N; pfam04052
258594003949	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
258594003950	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
258594003951	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
258594003952	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
258594003953	PAS fold; Region: PAS_7; pfam12860
258594003954	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594003955	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594003956	metal binding site [ion binding]; metal-binding site
258594003957	active site
258594003958	I-site; other site
258594003959	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594003960	5 probable transmembrane helices predicted byTMHMM2.0
258594003961	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
258594003962	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
258594003963	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
258594003964	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
258594003965	ligand binding site [chemical binding]; other site
258594003966	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
258594003967	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
258594003968	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
258594003969	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
258594003970	Ligand Binding Site [chemical binding]; other site
258594003971	FtsH Extracellular; Region: FtsH_ext; pfam06480
258594003972	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
258594003973	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594003974	Walker A motif; other site
258594003975	ATP binding site [chemical binding]; other site
258594003976	Walker B motif; other site
258594003977	arginine finger; other site
258594003978	Peptidase family M41; Region: Peptidase_M41; pfam01434
258594003979	2 probable transmembrane helices predicted byTMHMM2.0
258594003980	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
258594003981	6 probable transmembrane helices predicted byTMHMM2.0
258594003982	Predicted membrane protein [Function unknown]; Region: COG4541
258594003983	3 probable transmembrane helices predicted byTMHMM2.0
258594003984	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
258594003985	FAD binding domain; Region: FAD_binding_4; pfam01565
258594003986	FAD binding domain; Region: FAD_binding_4; pfam01565
258594003987	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
258594003988	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
258594003989	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
258594003990	Cysteine-rich domain; Region: CCG; pfam02754
258594003991	Cysteine-rich domain; Region: CCG; pfam02754
258594003992	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
258594003993	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
258594003994	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
258594003995	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
258594003996	5 probable transmembrane helices predicted byTMHMM2.0
258594003997	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
258594003998	L-lactate permease; Region: Lactate_perm; cl00701
258594003999	14 probable transmembrane helices predicted byTMHMM2.0
258594004000	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
258594004001	chaperonin GroEL; Reviewed; Region: groEL; PRK12852
258594004002	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
258594004003	ring oligomerisation interface [polypeptide binding]; other site
258594004004	ATP/Mg binding site [chemical binding]; other site
258594004005	stacking interactions; other site
258594004006	hinge regions; other site
258594004007	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
258594004008	oligomerisation interface [polypeptide binding]; other site
258594004009	mobile loop; other site
258594004010	roof hairpin; other site
258594004011	1 probable transmembrane helix predicted byTMHMM2.0
258594004012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594004013	putative substrate translocation pore; other site
258594004014	Major Facilitator Superfamily; Region: MFS_1; pfam07690
258594004015	12 probable transmembrane helices predicted byTMHMM2.0
258594004016	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
258594004017	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
258594004018	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
258594004019	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
258594004020	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
258594004021	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
258594004022	putative active site [active]
258594004023	YdjC motif; other site
258594004024	Mg binding site [ion binding]; other site
258594004025	putative homodimer interface [polypeptide binding]; other site
258594004026	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
258594004027	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
258594004028	Ligand binding site; other site
258594004029	Putative Catalytic site; other site
258594004030	DXD motif; other site
258594004031	2 probable transmembrane helices predicted byTMHMM2.0
258594004032	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
258594004033	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
258594004034	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
258594004035	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
258594004036	motif 1; other site
258594004037	dimer interface [polypeptide binding]; other site
258594004038	active site
258594004039	motif 2; other site
258594004040	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
258594004041	motif 3; other site
258594004042	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
258594004043	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
258594004044	UbiA prenyltransferase family; Region: UbiA; pfam01040
258594004045	7 probable transmembrane helices predicted byTMHMM2.0
258594004046	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
258594004047	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
258594004048	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
258594004049	active site
258594004050	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
258594004051	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
258594004052	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
258594004053	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
258594004054	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
258594004055	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
258594004056	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
258594004057	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
258594004058	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
258594004059	generic binding surface II; other site
258594004060	generic binding surface I; other site
258594004061	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
258594004062	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
258594004063	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
258594004064	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
258594004065	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
258594004066	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
258594004067	nucleoside/Zn binding site; other site
258594004068	dimer interface [polypeptide binding]; other site
258594004069	catalytic motif [active]
258594004070	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
258594004071	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
258594004072	RNA binding surface [nucleotide binding]; other site
258594004073	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
258594004074	active site
258594004075	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
258594004076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594004077	S-adenosylmethionine binding site [chemical binding]; other site
258594004078	HemK family putative methylases; Region: hemK_fam; TIGR00536
258594004079	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594004080	S-adenosylmethionine binding site [chemical binding]; other site
258594004081	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
258594004082	MoaE homodimer interface [polypeptide binding]; other site
258594004083	MoaD interaction [polypeptide binding]; other site
258594004084	active site residues [active]
258594004085	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
258594004086	MoaE interaction surface [polypeptide binding]; other site
258594004087	MoeB interaction surface [polypeptide binding]; other site
258594004088	thiocarboxylated glycine; other site
258594004089	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
258594004090	3 probable transmembrane helices predicted byTMHMM2.0
258594004091	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
258594004092	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
258594004093	GIY-YIG motif/motif A; other site
258594004094	active site
258594004095	catalytic site [active]
258594004096	putative DNA binding site [nucleotide binding]; other site
258594004097	metal binding site [ion binding]; metal-binding site
258594004098	UvrB/uvrC motif; Region: UVR; pfam02151
258594004099	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
258594004100	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
258594004101	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
258594004102	DNA-binding site [nucleotide binding]; DNA binding site
258594004103	RNA-binding motif; other site
258594004104	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
258594004105	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594004106	Response regulator receiver domain; Region: Response_reg; pfam00072
258594004107	active site
258594004108	phosphorylation site [posttranslational modification]
258594004109	intermolecular recognition site; other site
258594004110	dimerization interface [polypeptide binding]; other site
258594004111	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
258594004112	active site 1 [active]
258594004113	active site 2 [active]
258594004114	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
258594004115	active site 1 [active]
258594004116	dimer interface [polypeptide binding]; other site
258594004117	hexamer interface [polypeptide binding]; other site
258594004118	active site 2 [active]
258594004119	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
258594004120	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
258594004121	dimer interface [polypeptide binding]; other site
258594004122	motif 1; other site
258594004123	motif 2; other site
258594004124	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
258594004125	active site
258594004126	motif 3; other site
258594004127	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
258594004128	anticodon binding site; other site
258594004129	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
258594004130	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
258594004131	inhibitor-cofactor binding pocket; inhibition site
258594004132	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594004133	catalytic residue [active]
258594004134	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594004135	1 probable transmembrane helix predicted byTMHMM2.0
258594004136	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
258594004137	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594004138	active site
258594004139	motif I; other site
258594004140	motif II; other site
258594004141	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
258594004142	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
258594004143	3 probable transmembrane helices predicted byTMHMM2.0
258594004144	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
258594004145	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
258594004146	4 probable transmembrane helices predicted byTMHMM2.0
258594004147	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
258594004148	Protein of unknown function DUF58; Region: DUF58; pfam01882
258594004149	MoxR-like ATPases [General function prediction only]; Region: COG0714
258594004150	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594004151	Walker A motif; other site
258594004152	ATP binding site [chemical binding]; other site
258594004153	Walker B motif; other site
258594004154	arginine finger; other site
258594004155	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
258594004156	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
258594004157	putative active site [active]
258594004158	putative CoA binding site [chemical binding]; other site
258594004159	nudix motif; other site
258594004160	metal binding site [ion binding]; metal-binding site
258594004161	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
258594004162	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
258594004163	active site
258594004164	NTP binding site [chemical binding]; other site
258594004165	metal binding triad [ion binding]; metal-binding site
258594004166	1 probable transmembrane helix predicted byTMHMM2.0
258594004167	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
258594004168	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
258594004169	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594004170	FeS/SAM binding site; other site
258594004171	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
258594004172	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
258594004173	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
258594004174	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
258594004175	[2Fe-2S] cluster binding site [ion binding]; other site
258594004176	1 probable transmembrane helix predicted byTMHMM2.0
258594004177	cytochrome b; Provisional; Region: CYTB; MTH00191
258594004178	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
258594004179	Qi binding site; other site
258594004180	intrachain domain interface; other site
258594004181	interchain domain interface [polypeptide binding]; other site
258594004182	heme bH binding site [chemical binding]; other site
258594004183	heme bL binding site [chemical binding]; other site
258594004184	Qo binding site; other site
258594004185	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
258594004186	interchain domain interface [polypeptide binding]; other site
258594004187	intrachain domain interface; other site
258594004188	Qi binding site; other site
258594004189	Qo binding site; other site
258594004190	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
258594004191	11 probable transmembrane helices predicted byTMHMM2.0
258594004192	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
258594004193	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
258594004194	classical (c) SDRs; Region: SDR_c; cd05233
258594004195	NAD(P) binding site [chemical binding]; other site
258594004196	active site
258594004197	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
258594004198	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
258594004199	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
258594004200	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
258594004201	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
258594004202	HSP70 interaction site [polypeptide binding]; other site
258594004203	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
258594004204	substrate binding site [polypeptide binding]; other site
258594004205	dimer interface [polypeptide binding]; other site
258594004206	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
258594004207	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
258594004208	NAD binding site [chemical binding]; other site
258594004209	homotetramer interface [polypeptide binding]; other site
258594004210	homodimer interface [polypeptide binding]; other site
258594004211	substrate binding site [chemical binding]; other site
258594004212	active site
258594004213	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
258594004214	catalytic core [active]
258594004215	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
258594004216	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
258594004217	Tetramer interface [polypeptide binding]; other site
258594004218	active site
258594004219	FMN-binding site [chemical binding]; other site
258594004220	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
258594004221	cyclase homology domain; Region: CHD; cd07302
258594004222	nucleotidyl binding site; other site
258594004223	metal binding site [ion binding]; metal-binding site
258594004224	dimer interface [polypeptide binding]; other site
258594004225	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
258594004226	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
258594004227	metal ion-dependent adhesion site (MIDAS); other site
258594004228	1 probable transmembrane helix predicted byTMHMM2.0
258594004229	putative alcohol dehydrogenase; Provisional; Region: PRK09860
258594004230	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
258594004231	dimer interface [polypeptide binding]; other site
258594004232	active site
258594004233	metal binding site [ion binding]; metal-binding site
258594004234	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
258594004235	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
258594004236	NAD(P) binding site [chemical binding]; other site
258594004237	catalytic residues [active]
258594004238	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
258594004239	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594004240	Walker A motif; other site
258594004241	ATP binding site [chemical binding]; other site
258594004242	Walker B motif; other site
258594004243	arginine finger; other site
258594004244	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
258594004245	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
258594004246	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
258594004247	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
258594004248	VWA-like domain (DUF2201); Region: DUF2201; pfam09967
258594004249	metal ion-dependent adhesion site (MIDAS); other site
258594004250	AAA domain; Region: AAA_14; pfam13173
258594004251	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
258594004252	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
258594004253	Uncharacterized conserved protein [Function unknown]; Region: COG5476
258594004254	MlrC C-terminus; Region: MlrC_C; pfam07171
258594004255	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
258594004256	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594004257	Walker A/P-loop; other site
258594004258	ATP binding site [chemical binding]; other site
258594004259	Q-loop/lid; other site
258594004260	ABC transporter signature motif; other site
258594004261	Walker B; other site
258594004262	D-loop; other site
258594004263	H-loop/switch region; other site
258594004264	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
258594004265	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594004266	Walker A/P-loop; other site
258594004267	ATP binding site [chemical binding]; other site
258594004268	Q-loop/lid; other site
258594004269	ABC transporter signature motif; other site
258594004270	Walker B; other site
258594004271	D-loop; other site
258594004272	H-loop/switch region; other site
258594004273	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
258594004274	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
258594004275	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
258594004276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594004277	dimer interface [polypeptide binding]; other site
258594004278	conserved gate region; other site
258594004279	putative PBP binding loops; other site
258594004280	ABC-ATPase subunit interface; other site
258594004281	4 probable transmembrane helices predicted byTMHMM2.0
258594004282	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
258594004283	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594004284	dimer interface [polypeptide binding]; other site
258594004285	conserved gate region; other site
258594004286	putative PBP binding loops; other site
258594004287	ABC-ATPase subunit interface; other site
258594004288	6 probable transmembrane helices predicted byTMHMM2.0
258594004289	hypothetical protein; Provisional; Region: PRK07338
258594004290	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
258594004291	metal binding site [ion binding]; metal-binding site
258594004292	dimer interface [polypeptide binding]; other site
258594004293	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
258594004294	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
258594004295	2 probable transmembrane helices predicted byTMHMM2.0
258594004296	FOG: CBS domain [General function prediction only]; Region: COG0517
258594004297	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
258594004298	3 probable transmembrane helices predicted byTMHMM2.0
258594004299	CHAD domain; Region: CHAD; pfam05235
258594004300	2 probable transmembrane helices predicted byTMHMM2.0
258594004301	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
258594004302	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
258594004303	dimer interface [polypeptide binding]; other site
258594004304	PYR/PP interface [polypeptide binding]; other site
258594004305	TPP binding site [chemical binding]; other site
258594004306	substrate binding site [chemical binding]; other site
258594004307	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
258594004308	TPP-binding site; other site
258594004309	4Fe-4S binding domain; Region: Fer4; pfam00037
258594004310	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
258594004311	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
258594004312	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
258594004313	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
258594004314	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
258594004315	dimer interface [polypeptide binding]; other site
258594004316	PYR/PP interface [polypeptide binding]; other site
258594004317	TPP binding site [chemical binding]; other site
258594004318	substrate binding site [chemical binding]; other site
258594004319	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
258594004320	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
258594004321	TPP-binding site [chemical binding]; other site
258594004322	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
258594004323	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
258594004324	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594004325	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
258594004326	acyl-activating enzyme (AAE) consensus motif; other site
258594004327	AMP binding site [chemical binding]; other site
258594004328	active site
258594004329	CoA binding site [chemical binding]; other site
258594004330	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594004331	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594004332	TM-ABC transporter signature motif; other site
258594004333	8 probable transmembrane helices predicted byTMHMM2.0
258594004334	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594004335	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594004336	TM-ABC transporter signature motif; other site
258594004337	9 probable transmembrane helices predicted byTMHMM2.0
258594004338	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594004339	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594004340	Walker A/P-loop; other site
258594004341	ATP binding site [chemical binding]; other site
258594004342	Q-loop/lid; other site
258594004343	ABC transporter signature motif; other site
258594004344	Walker B; other site
258594004345	D-loop; other site
258594004346	H-loop/switch region; other site
258594004347	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594004348	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594004349	Walker A/P-loop; other site
258594004350	ATP binding site [chemical binding]; other site
258594004351	Q-loop/lid; other site
258594004352	ABC transporter signature motif; other site
258594004353	Walker B; other site
258594004354	D-loop; other site
258594004355	H-loop/switch region; other site
258594004356	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
258594004357	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
258594004358	acyl-activating enzyme (AAE) consensus motif; other site
258594004359	putative AMP binding site [chemical binding]; other site
258594004360	putative active site [active]
258594004361	putative CoA binding site [chemical binding]; other site
258594004362	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
258594004363	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594004364	putative ligand binding site [chemical binding]; other site
258594004365	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
258594004366	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594004367	active site
258594004368	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
258594004369	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
258594004370	active site
258594004371	enoyl-CoA hydratase; Provisional; Region: PRK08290
258594004372	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594004373	substrate binding site [chemical binding]; other site
258594004374	oxyanion hole (OAH) forming residues; other site
258594004375	trimer interface [polypeptide binding]; other site
258594004376	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
258594004377	4 probable transmembrane helices predicted byTMHMM2.0
258594004378	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
258594004379	TonB system transport protein ExbD, group 1; Region: ExbD_1; TIGR02803
258594004380	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
258594004381	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
258594004382	1 probable transmembrane helix predicted byTMHMM2.0
258594004383	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
258594004384	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594004385	acyl-activating enzyme (AAE) consensus motif; other site
258594004386	AMP binding site [chemical binding]; other site
258594004387	active site
258594004388	CoA binding site [chemical binding]; other site
258594004389	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
258594004390	2 probable transmembrane helices predicted byTMHMM2.0
258594004391	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
258594004392	6 probable transmembrane helices predicted byTMHMM2.0
258594004393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594004394	Response regulator receiver domain; Region: Response_reg; pfam00072
258594004395	active site
258594004396	phosphorylation site [posttranslational modification]
258594004397	intermolecular recognition site; other site
258594004398	dimerization interface [polypeptide binding]; other site
258594004399	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
258594004400	DNA binding residues [nucleotide binding]
258594004401	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
258594004402	Na binding site [ion binding]; other site
258594004403	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594004404	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594004405	dimer interface [polypeptide binding]; other site
258594004406	phosphorylation site [posttranslational modification]
258594004407	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594004408	ATP binding site [chemical binding]; other site
258594004409	Mg2+ binding site [ion binding]; other site
258594004410	G-X-G motif; other site
258594004411	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594004412	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594004413	active site
258594004414	phosphorylation site [posttranslational modification]
258594004415	intermolecular recognition site; other site
258594004416	dimerization interface [polypeptide binding]; other site
258594004417	14 probable transmembrane helices predicted byTMHMM2.0
258594004418	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594004419	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
258594004420	putative ligand binding site [chemical binding]; other site
258594004421	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594004422	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594004423	TM-ABC transporter signature motif; other site
258594004424	7 probable transmembrane helices predicted byTMHMM2.0
258594004425	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594004426	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594004427	TM-ABC transporter signature motif; other site
258594004428	8 probable transmembrane helices predicted byTMHMM2.0
258594004429	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
258594004430	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594004431	Walker A/P-loop; other site
258594004432	ATP binding site [chemical binding]; other site
258594004433	Q-loop/lid; other site
258594004434	ABC transporter signature motif; other site
258594004435	Walker B; other site
258594004436	D-loop; other site
258594004437	H-loop/switch region; other site
258594004438	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
258594004439	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594004440	Walker A/P-loop; other site
258594004441	ATP binding site [chemical binding]; other site
258594004442	Q-loop/lid; other site
258594004443	ABC transporter signature motif; other site
258594004444	Walker B; other site
258594004445	D-loop; other site
258594004446	H-loop/switch region; other site
258594004447	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
258594004448	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
258594004449	cobalamin synthase; Reviewed; Region: cobS; PRK00235
258594004450	5 probable transmembrane helices predicted byTMHMM2.0
258594004451	1 probable transmembrane helix predicted byTMHMM2.0
258594004452	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
258594004453	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
258594004454	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
258594004455	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
258594004456	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594004457	motif II; other site
258594004458	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
258594004459	10 probable transmembrane helices predicted byTMHMM2.0
258594004460	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
258594004461	Ligand Binding Site [chemical binding]; other site
258594004462	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
258594004463	Ligand Binding Site [chemical binding]; other site
258594004464	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
258594004465	FAD binding domain; Region: FAD_binding_4; pfam01565
258594004466	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
258594004467	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
258594004468	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
258594004469	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
258594004470	2 probable transmembrane helices predicted byTMHMM2.0
258594004471	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
258594004472	MgtE intracellular N domain; Region: MgtE_N; cl15244
258594004473	FliG C-terminal domain; Region: FliG_C; pfam01706
258594004474	flagellar assembly protein H; Validated; Region: fliH; PRK06032
258594004475	Flagellar assembly protein FliH; Region: FliH; pfam02108
258594004476	flagellar motor switch protein; Reviewed; Region: PRK08916
258594004477	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
258594004478	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594004479	Walker A motif; other site
258594004480	ATP binding site [chemical binding]; other site
258594004481	Walker B motif; other site
258594004482	arginine finger; other site
258594004483	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
258594004484	1 probable transmembrane helix predicted byTMHMM2.0
258594004485	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
258594004486	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
258594004487	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
258594004488	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
258594004489	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
258594004490	AAA domain; Region: AAA_30; pfam13604
258594004491	Walker A motif; other site
258594004492	ATP binding site [chemical binding]; other site
258594004493	Family description; Region: UvrD_C_2; pfam13538
258594004494	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
258594004495	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
258594004496	dimerization interface [polypeptide binding]; other site
258594004497	DPS ferroxidase diiron center [ion binding]; other site
258594004498	ion pore; other site
258594004499	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
258594004500	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
258594004501	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
258594004502	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
258594004503	catalytic site [active]
258594004504	subunit interface [polypeptide binding]; other site
258594004505	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
258594004506	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
258594004507	catalytic site [active]
258594004508	Yqey-like protein; Region: YqeY; pfam09424
258594004509	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
258594004510	6 probable transmembrane helices predicted byTMHMM2.0
258594004511	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
258594004512	putative hydrophobic ligand binding site [chemical binding]; other site
258594004513	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594004514	dimerization interface [polypeptide binding]; other site
258594004515	putative DNA binding site [nucleotide binding]; other site
258594004516	putative Zn2+ binding site [ion binding]; other site
258594004517	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
258594004518	6 probable transmembrane helices predicted byTMHMM2.0
258594004519	N-formylglutamate amidohydrolase; Region: FGase; cl01522
258594004520	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
258594004521	putative active site pocket [active]
258594004522	dimerization interface [polypeptide binding]; other site
258594004523	putative catalytic residue [active]
258594004524	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475
258594004525	Zn binding site [ion binding]; other site
258594004526	DNA primase, catalytic core; Region: dnaG; TIGR01391
258594004527	CHC2 zinc finger; Region: zf-CHC2; cl17510
258594004528	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
258594004529	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
258594004530	active site
258594004531	metal binding site [ion binding]; metal-binding site
258594004532	interdomain interaction site; other site
258594004533	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
258594004534	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
258594004535	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
258594004536	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
258594004537	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
258594004538	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594004539	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
258594004540	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
258594004541	DNA binding residues [nucleotide binding]
258594004542	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
258594004543	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594004544	sequence-specific DNA binding site [nucleotide binding]; other site
258594004545	salt bridge; other site
258594004546	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
258594004547	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
258594004548	Transposase domain (DUF772); Region: DUF772; pfam05598
258594004549	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
258594004550	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
258594004551	IS element
258594004552	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
258594004553	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
258594004554	Histidine kinase; Region: HisKA_2; pfam07568
258594004555	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594004556	ATP binding site [chemical binding]; other site
258594004557	Mg2+ binding site [ion binding]; other site
258594004558	G-X-G motif; other site
258594004559	4 probable transmembrane helices predicted byTMHMM2.0
258594004560	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
258594004561	dimerization interface [polypeptide binding]; other site
258594004562	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594004563	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594004564	metal binding site [ion binding]; metal-binding site
258594004565	active site
258594004566	I-site; other site
258594004567	2 probable transmembrane helices predicted byTMHMM2.0
258594004568	hypothetical protein; Provisional; Region: PRK06194
258594004569	classical (c) SDRs; Region: SDR_c; cd05233
258594004570	NAD(P) binding site [chemical binding]; other site
258594004571	active site
258594004572	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
258594004573	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
258594004574	dimer interface [polypeptide binding]; other site
258594004575	active site
258594004576	CoA binding pocket [chemical binding]; other site
258594004577	Cupin domain; Region: Cupin_2; cl17218
258594004578	Restriction endonuclease; Region: Mrr_cat; pfam04471
258594004579	2 probable transmembrane helices predicted byTMHMM2.0
258594004580	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
258594004581	intracellular protease, PfpI family; Region: PfpI; TIGR01382
258594004582	proposed catalytic triad [active]
258594004583	conserved cys residue [active]
258594004584	2 probable transmembrane helices predicted byTMHMM2.0
258594004585	Transglycosylase SLT domain; Region: SLT_2; pfam13406
258594004586	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
258594004587	N-acetyl-D-glucosamine binding site [chemical binding]; other site
258594004588	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
258594004589	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
258594004590	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
258594004591	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
258594004592	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
258594004593	Ligand Binding Site [chemical binding]; other site
258594004594	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594004595	S-adenosylmethionine binding site [chemical binding]; other site
258594004596	IS element
258594004597	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
258594004598	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
258594004599	active site
258594004600	FMN binding site [chemical binding]; other site
258594004601	substrate binding site [chemical binding]; other site
258594004602	homotetramer interface [polypeptide binding]; other site
258594004603	catalytic residue [active]
258594004604	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
258594004605	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594004606	PAS domain; Region: PAS_9; pfam13426
258594004607	putative active site [active]
258594004608	heme pocket [chemical binding]; other site
258594004609	PAS domain; Region: PAS_9; pfam13426
258594004610	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
258594004611	putative active site [active]
258594004612	heme pocket [chemical binding]; other site
258594004613	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594004614	dimer interface [polypeptide binding]; other site
258594004615	phosphorylation site [posttranslational modification]
258594004616	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594004617	ATP binding site [chemical binding]; other site
258594004618	Mg2+ binding site [ion binding]; other site
258594004619	G-X-G motif; other site
258594004620	3 probable transmembrane helices predicted byTMHMM2.0
258594004621	Response regulator receiver domain; Region: Response_reg; pfam00072
258594004622	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594004623	active site
258594004624	phosphorylation site [posttranslational modification]
258594004625	intermolecular recognition site; other site
258594004626	dimerization interface [polypeptide binding]; other site
258594004627	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
258594004628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594004629	active site
258594004630	phosphorylation site [posttranslational modification]
258594004631	intermolecular recognition site; other site
258594004632	dimerization interface [polypeptide binding]; other site
258594004633	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
258594004634	DNA binding residues [nucleotide binding]
258594004635	dimerization interface [polypeptide binding]; other site
258594004636	possible cytochrome bd-I oxidase subunit I [EC:1.10.3.-]; authentic frameshift
258594004637	3 probable transmembrane helices predicted byTMHMM2.0
258594004638	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
258594004639	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
258594004640	8 probable transmembrane helices predicted byTMHMM2.0
258594004641	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
258594004642	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594004643	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
258594004644	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594004645	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
258594004646	Histidine kinase; Region: HisKA_2; pfam07568
258594004647	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
258594004648	ATP binding site [chemical binding]; other site
258594004649	Mg2+ binding site [ion binding]; other site
258594004650	G-X-G motif; other site
258594004651	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
258594004652	Fusaric acid resistance protein family; Region: FUSC; pfam04632
258594004653	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
258594004654	11 probable transmembrane helices predicted byTMHMM2.0
258594004655	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
258594004656	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
258594004657	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594004658	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594004659	1 probable transmembrane helix predicted byTMHMM2.0
258594004660	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
258594004661	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594004662	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
258594004663	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
258594004664	substrate binding site [chemical binding]; other site
258594004665	activation loop (A-loop); other site
258594004666	Predicted ATPase [General function prediction only]; Region: COG3899
258594004667	AAA ATPase domain; Region: AAA_16; pfam13191
258594004668	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
258594004669	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
258594004670	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594004671	dimer interface [polypeptide binding]; other site
258594004672	phosphorylation site [posttranslational modification]
258594004673	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594004674	ATP binding site [chemical binding]; other site
258594004675	Mg2+ binding site [ion binding]; other site
258594004676	G-X-G motif; other site
258594004677	fumarate hydratase; Reviewed; Region: fumC; PRK00485
258594004678	Class II fumarases; Region: Fumarase_classII; cd01362
258594004679	active site
258594004680	tetramer interface [polypeptide binding]; other site
258594004681	Uncharacterized conserved protein [Function unknown]; Region: COG2966
258594004682	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
258594004683	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
258594004684	8 probable transmembrane helices predicted byTMHMM2.0
258594004685	malate:quinone oxidoreductase; Validated; Region: PRK05257
258594004686	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
258594004687	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
258594004688	active site
258594004689	DNA binding site [nucleotide binding]
258594004690	Int/Topo IB signature motif; other site
258594004691	IS element
258594004692	Secretin and TonB N terminus short domain; Region: STN; smart00965
258594004693	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
258594004694	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594004695	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
258594004696	DNA binding residues [nucleotide binding]
258594004697	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
258594004698	FecR protein; Region: FecR; pfam04773
258594004699	1 probable transmembrane helix predicted byTMHMM2.0
258594004700	haemagglutination activity domain; Region: Haemagg_act; cl05436
258594004701	Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545
258594004702	Secretin and TonB N terminus short domain; Region: STN; smart00965
258594004703	TonB C terminal; Region: TonB_2; pfam13103
258594004704	RNA polymerase sigma factor; Reviewed; Region: PRK12527
258594004705	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
258594004706	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
258594004707	FecR protein; Region: FecR; pfam04773
258594004708	haemagglutination activity domain; Region: Haemagg_act; pfam05860
258594004709	Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545
258594004710	1 probable transmembrane helix predicted byTMHMM2.0
258594004711	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
258594004712	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
258594004713	1 probable transmembrane helix predicted byTMHMM2.0
258594004714	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
258594004715	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
258594004716	1 probable transmembrane helix predicted byTMHMM2.0
258594004717	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
258594004718	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
258594004719	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
258594004720	FecR protein; Region: FecR; pfam04773
258594004721	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
258594004722	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
258594004723	Domain of unknown function (DUF2341); Region: DUF2341; pfam10102
258594004724	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
258594004725	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
258594004726	3 probable transmembrane helices predicted byTMHMM2.0
258594004727	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
258594004728	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
258594004729	1 probable transmembrane helix predicted byTMHMM2.0
258594004730	TonB C terminal; Region: TonB_2; pfam13103
258594004731	1 probable transmembrane helix predicted byTMHMM2.0
258594004732	1 probable transmembrane helix predicted byTMHMM2.0
258594004733	peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925
258594004734	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
258594004735	1 probable transmembrane helix predicted byTMHMM2.0
258594004736	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
258594004737	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
258594004738	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
258594004739	N-acetyl-D-glucosamine binding site [chemical binding]; other site
258594004740	catalytic residue [active]
258594004741	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
258594004742	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
258594004743	substrate binding pocket [chemical binding]; other site
258594004744	1 probable transmembrane helix predicted byTMHMM2.0
258594004745	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
258594004746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
258594004747	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
258594004748	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594004749	dimer interface [polypeptide binding]; other site
258594004750	conserved gate region; other site
258594004751	putative PBP binding loops; other site
258594004752	ABC-ATPase subunit interface; other site
258594004753	12 probable transmembrane helices predicted byTMHMM2.0
258594004754	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
258594004755	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
258594004756	Walker A/P-loop; other site
258594004757	ATP binding site [chemical binding]; other site
258594004758	Q-loop/lid; other site
258594004759	ABC transporter signature motif; other site
258594004760	Walker B; other site
258594004761	D-loop; other site
258594004762	H-loop/switch region; other site
258594004763	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
258594004764	Sulfatase; Region: Sulfatase; cl17466
258594004765	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
258594004766	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
258594004767	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
258594004768	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594004769	CoA binding site [chemical binding]; other site
258594004770	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
258594004771	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
258594004772	FMN binding site [chemical binding]; other site
258594004773	substrate binding site [chemical binding]; other site
258594004774	putative catalytic residue [active]
258594004775	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
258594004776	NifU-like domain; Region: NifU; cl00484
258594004777	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
258594004778	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
258594004779	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
258594004780	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
258594004781	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
258594004782	Nif-specific regulatory protein; Region: nifA; TIGR01817
258594004783	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
258594004784	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594004785	Walker A motif; other site
258594004786	ATP binding site [chemical binding]; other site
258594004787	Walker B motif; other site
258594004788	arginine finger; other site
258594004789	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
258594004790	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
258594004791	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
258594004792	Nucleotide-binding sites [chemical binding]; other site
258594004793	Walker A motif; other site
258594004794	Switch I region of nucleotide binding site; other site
258594004795	Fe4S4 binding sites [ion binding]; other site
258594004796	Switch II region of nucleotide binding site; other site
258594004797	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
258594004798	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
258594004799	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
258594004800	dimer interface [polypeptide binding]; other site
258594004801	active site
258594004802	metal binding site [ion binding]; metal-binding site
258594004803	glutathione binding site [chemical binding]; other site
258594004804	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
258594004805	Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of,  the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977
258594004806	V-containing nitrogenase, delta subunit; Region: vnfG_nitrog; TIGR02930
258594004807	Nitrogenase_VFe_beta -like: Nitrogenase VFe protein, beta subunit like. This group contains proteins similar to the beta subunits of  the VFe protein of the vanadium-dependent (V-) nitrogenase.  Nitrogenase catalyzes the ATP-dependent reduction of...; Region: Nitrogenase_VFe_beta_like; cd01973
258594004808	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
258594004809	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
258594004810	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
258594004811	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
258594004812	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594004813	dimer interface [polypeptide binding]; other site
258594004814	conserved gate region; other site
258594004815	ABC-ATPase subunit interface; other site
258594004816	5 probable transmembrane helices predicted byTMHMM2.0
258594004817	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
258594004818	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
258594004819	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
258594004820	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
258594004821	Walker A/P-loop; other site
258594004822	ATP binding site [chemical binding]; other site
258594004823	Q-loop/lid; other site
258594004824	ABC transporter signature motif; other site
258594004825	Walker B; other site
258594004826	D-loop; other site
258594004827	H-loop/switch region; other site
258594004828	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
258594004829	Domain of unknown function (DUF4213); Region: DUF4213; pfam13938
258594004830	Domain of unknown function (DUF364); Region: DUF364; pfam04016
258594004831	ATP-grasp domain; Region: ATP-grasp_4; cl17255
258594004832	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
258594004833	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
258594004834	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594004835	Walker A/P-loop; other site
258594004836	ATP binding site [chemical binding]; other site
258594004837	ABC transporter; Region: ABC_tran; pfam00005
258594004838	Q-loop/lid; other site
258594004839	ABC transporter signature motif; other site
258594004840	Walker B; other site
258594004841	H-loop/switch region; other site
258594004842	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
258594004843	putative FMN binding site [chemical binding]; other site
258594004844	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
258594004845	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
258594004846	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
258594004847	DNA-binding site [nucleotide binding]; DNA binding site
258594004848	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
258594004849	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594004850	homodimer interface [polypeptide binding]; other site
258594004851	catalytic residue [active]
258594004852	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
258594004853	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
258594004854	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594004855	putative PBP binding loops; other site
258594004856	ABC-ATPase subunit interface; other site
258594004857	6 probable transmembrane helices predicted byTMHMM2.0
258594004858	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
258594004859	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594004860	dimer interface [polypeptide binding]; other site
258594004861	conserved gate region; other site
258594004862	putative PBP binding loops; other site
258594004863	ABC-ATPase subunit interface; other site
258594004864	6 probable transmembrane helices predicted byTMHMM2.0
258594004865	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
258594004866	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
258594004867	Walker A/P-loop; other site
258594004868	ATP binding site [chemical binding]; other site
258594004869	Q-loop/lid; other site
258594004870	ABC transporter signature motif; other site
258594004871	Walker B; other site
258594004872	D-loop; other site
258594004873	H-loop/switch region; other site
258594004874	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
258594004875	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
258594004876	Walker A/P-loop; other site
258594004877	ATP binding site [chemical binding]; other site
258594004878	Q-loop/lid; other site
258594004879	ABC transporter signature motif; other site
258594004880	Walker B; other site
258594004881	D-loop; other site
258594004882	H-loop/switch region; other site
258594004883	TOBE domain; Region: TOBE_2; pfam08402
258594004884	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
258594004885	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
258594004886	catalytic triad [active]
258594004887	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
258594004888	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
258594004889	putative amidase; Provisional; Region: PRK06169
258594004890	Amidase; Region: Amidase; pfam01425
258594004891	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
258594004892	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
258594004893	catalytic triad [active]
258594004894	allophanate hydrolase; Provisional; Region: PRK08186
258594004895	Amidase; Region: Amidase; cl11426
258594004896	urea carboxylase; Region: urea_carbox; TIGR02712
258594004897	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
258594004898	ATP-grasp domain; Region: ATP-grasp_4; cl17255
258594004899	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
258594004900	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
258594004901	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
258594004902	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
258594004903	carboxyltransferase (CT) interaction site; other site
258594004904	biotinylation site [posttranslational modification]; other site
258594004905	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
258594004906	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
258594004907	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
258594004908	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
258594004909	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
258594004910	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
258594004911	Walker A/P-loop; other site
258594004912	ATP binding site [chemical binding]; other site
258594004913	Q-loop/lid; other site
258594004914	ABC transporter signature motif; other site
258594004915	Walker B; other site
258594004916	D-loop; other site
258594004917	H-loop/switch region; other site
258594004918	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
258594004919	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594004920	dimer interface [polypeptide binding]; other site
258594004921	conserved gate region; other site
258594004922	putative PBP binding loops; other site
258594004923	ABC-ATPase subunit interface; other site
258594004924	5 probable transmembrane helices predicted byTMHMM2.0
258594004925	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
258594004926	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
258594004927	1 probable transmembrane helix predicted byTMHMM2.0
258594004928	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594004929	enoyl-CoA hydratase; Provisional; Region: PRK06688
258594004930	substrate binding site [chemical binding]; other site
258594004931	oxyanion hole (OAH) forming residues; other site
258594004932	trimer interface [polypeptide binding]; other site
258594004933	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
258594004934	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594004935	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
258594004936	acyl-activating enzyme (AAE) consensus motif; other site
258594004937	putative AMP binding site [chemical binding]; other site
258594004938	putative active site [active]
258594004939	putative CoA binding site [chemical binding]; other site
258594004940	Transcriptional regulator [Transcription]; Region: IclR; COG1414
258594004941	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
258594004942	Bacterial transcriptional regulator; Region: IclR; pfam01614
258594004943	enoyl-CoA hydratase; Region: PLN02864
258594004944	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
258594004945	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
258594004946	dimer interaction site [polypeptide binding]; other site
258594004947	substrate-binding tunnel; other site
258594004948	active site
258594004949	catalytic site [active]
258594004950	substrate binding site [chemical binding]; other site
258594004951	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594004952	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
258594004953	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594004954	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594004955	Walker A/P-loop; other site
258594004956	ATP binding site [chemical binding]; other site
258594004957	Q-loop/lid; other site
258594004958	ABC transporter signature motif; other site
258594004959	Walker B; other site
258594004960	D-loop; other site
258594004961	H-loop/switch region; other site
258594004962	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594004963	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594004964	Walker A/P-loop; other site
258594004965	ATP binding site [chemical binding]; other site
258594004966	Q-loop/lid; other site
258594004967	ABC transporter signature motif; other site
258594004968	Walker B; other site
258594004969	D-loop; other site
258594004970	H-loop/switch region; other site
258594004971	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594004972	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594004973	TM-ABC transporter signature motif; other site
258594004974	8 probable transmembrane helices predicted byTMHMM2.0
258594004975	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594004976	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594004977	TM-ABC transporter signature motif; other site
258594004978	8 probable transmembrane helices predicted byTMHMM2.0
258594004979	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
258594004980	12 probable transmembrane helices predicted byTMHMM2.0
258594004981	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
258594004982	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
258594004983	E3 interaction surface; other site
258594004984	lipoyl attachment site [posttranslational modification]; other site
258594004985	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594004986	YtkA-like; Region: YtkA; pfam13115
258594004987	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
258594004988	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
258594004989	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594004990	catalytic residue [active]
258594004991	serine O-acetyltransferase; Region: cysE; TIGR01172
258594004992	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
258594004993	trimer interface [polypeptide binding]; other site
258594004994	active site
258594004995	substrate binding site [chemical binding]; other site
258594004996	CoA binding site [chemical binding]; other site
258594004997	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
258594004998	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
258594004999	Walker A/P-loop; other site
258594005000	ATP binding site [chemical binding]; other site
258594005001	Q-loop/lid; other site
258594005002	ABC transporter signature motif; other site
258594005003	Walker B; other site
258594005004	D-loop; other site
258594005005	H-loop/switch region; other site
258594005006	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
258594005007	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
258594005008	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594005009	dimer interface [polypeptide binding]; other site
258594005010	conserved gate region; other site
258594005011	ABC-ATPase subunit interface; other site
258594005012	4 probable transmembrane helices predicted byTMHMM2.0
258594005013	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
258594005014	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
258594005015	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
258594005016	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594005017	acyl-activating enzyme (AAE) consensus motif; other site
258594005018	AMP binding site [chemical binding]; other site
258594005019	active site
258594005020	CoA binding site [chemical binding]; other site
258594005021	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
258594005022	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
258594005023	1 probable transmembrane helix predicted byTMHMM2.0
258594005024	Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357
258594005025	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
258594005026	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
258594005027	putative active site pocket [active]
258594005028	dimerization interface [polypeptide binding]; other site
258594005029	putative catalytic residue [active]
258594005030	Fe-only nitrogenase accessory protein AnfO; Region: anfO_nitrog; TIGR02940
258594005031	Fe-only nitrogenase, beta subunit; Region: anfK_nitrog; TIGR02931
258594005032	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
258594005033	Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; pfam03139
258594005034	nitrogenase iron-iron protein, alpha chain; Region: ANFD; TIGR01861
258594005035	Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of,  the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977
258594005036	nitrogenase iron protein; Region: nifH; TIGR01287
258594005037	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
258594005038	Nucleotide-binding sites [chemical binding]; other site
258594005039	Walker A motif; other site
258594005040	Switch I region of nucleotide binding site; other site
258594005041	Fe4S4 binding sites [ion binding]; other site
258594005042	Switch II region of nucleotide binding site; other site
258594005043	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
258594005044	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
258594005045	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594005046	Walker A motif; other site
258594005047	ATP binding site [chemical binding]; other site
258594005048	Walker B motif; other site
258594005049	arginine finger; other site
258594005050	AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255
258594005051	putative nucleotide binding site [chemical binding]; other site
258594005052	putative substrate binding site [chemical binding]; other site
258594005053	AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255
258594005054	putative nucleotide binding site [chemical binding]; other site
258594005055	putative substrate binding site [chemical binding]; other site
258594005056	Transcriptional regulators [Transcription]; Region: GntR; COG1802
258594005057	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
258594005058	DNA-binding site [nucleotide binding]; DNA binding site
258594005059	FCD domain; Region: FCD; pfam07729
258594005060	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
258594005061	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594005062	Walker A/P-loop; other site
258594005063	ATP binding site [chemical binding]; other site
258594005064	Q-loop/lid; other site
258594005065	ABC transporter signature motif; other site
258594005066	Walker B; other site
258594005067	D-loop; other site
258594005068	H-loop/switch region; other site
258594005069	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
258594005070	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
258594005071	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594005072	Walker A/P-loop; other site
258594005073	ATP binding site [chemical binding]; other site
258594005074	Q-loop/lid; other site
258594005075	ABC transporter signature motif; other site
258594005076	Walker B; other site
258594005077	D-loop; other site
258594005078	H-loop/switch region; other site
258594005079	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
258594005080	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
258594005081	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496
258594005082	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
258594005083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594005084	dimer interface [polypeptide binding]; other site
258594005085	conserved gate region; other site
258594005086	putative PBP binding loops; other site
258594005087	ABC-ATPase subunit interface; other site
258594005088	6 probable transmembrane helices predicted byTMHMM2.0
258594005089	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
258594005090	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594005091	dimer interface [polypeptide binding]; other site
258594005092	conserved gate region; other site
258594005093	ABC-ATPase subunit interface; other site
258594005094	3 probable transmembrane helices predicted byTMHMM2.0
258594005095	acyl-CoA synthetase; Validated; Region: PRK06178
258594005096	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594005097	Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935
258594005098	putative AMP binding site [chemical binding]; other site
258594005099	putative active site [active]
258594005100	acyl-activating enzyme (AAE) consensus motif; other site
258594005101	putative CoA binding site [chemical binding]; other site
258594005102	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
258594005103	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
258594005104	ATP-grasp domain; Region: ATP-grasp_4; cl17255
258594005105	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
258594005106	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
258594005107	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
258594005108	carboxyltransferase (CT) interaction site; other site
258594005109	biotinylation site [posttranslational modification]; other site
258594005110	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
258594005111	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
258594005112	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
258594005113	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
258594005114	active site 1 [active]
258594005115	active site 2 [active]
258594005116	2 probable transmembrane helices predicted byTMHMM2.0
258594005117	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
258594005118	Subunit I/III interface [polypeptide binding]; other site
258594005119	5 probable transmembrane helices predicted byTMHMM2.0
258594005120	2 probable transmembrane helices predicted byTMHMM2.0
258594005121	Cytochrome c; Region: Cytochrom_C; pfam00034
258594005122	1 probable transmembrane helix predicted byTMHMM2.0
258594005123	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
258594005124	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
258594005125	K-pathway; other site
258594005126	Binuclear center (active site) [active]
258594005127	Putative proton exit pathway; other site
258594005128	12 probable transmembrane helices predicted byTMHMM2.0
258594005129	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594005130	MoxR-like ATPases [General function prediction only]; Region: COG0714
258594005131	Walker A motif; other site
258594005132	ATP binding site [chemical binding]; other site
258594005133	Walker B motif; other site
258594005134	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
258594005135	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
258594005136	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
258594005137	metal ion-dependent adhesion site (MIDAS); other site
258594005138	possible transporter, possible approximate 180bp deletion associated with frameshift;conserved hypothetical protein
258594005139	2 probable transmembrane helices predicted byTMHMM2.0
258594005140	2 probable transmembrane helices predicted byTMHMM2.0
258594005141	Domain of unknown function (DUF4424); Region: DUF4424; pfam14415
258594005142	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
258594005143	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
258594005144	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
258594005145	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
258594005146	Peptidase C26; Region: Peptidase_C26; pfam07722
258594005147	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
258594005148	catalytic triad [active]
258594005149	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
258594005150	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
258594005151	Cl- selectivity filter; other site
258594005152	Cl- binding residues [ion binding]; other site
258594005153	pore gating glutamate residue; other site
258594005154	dimer interface [polypeptide binding]; other site
258594005155	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
258594005156	9 probable transmembrane helices predicted byTMHMM2.0
258594005157	allophanate hydrolase; Provisional; Region: PRK08186
258594005158	Amidase; Region: Amidase; cl11426
258594005159	Transcriptional regulators [Transcription]; Region: GntR; COG1802
258594005160	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
258594005161	DNA-binding site [nucleotide binding]; DNA binding site
258594005162	FCD domain; Region: FCD; pfam07729
258594005163	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
258594005164	SnoaL-like domain; Region: SnoaL_3; pfam13474
258594005165	amidase; Provisional; Region: PRK09201
258594005166	Amidase; Region: Amidase; pfam01425
258594005167	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
258594005168	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594005169	Walker A/P-loop; other site
258594005170	ATP binding site [chemical binding]; other site
258594005171	Q-loop/lid; other site
258594005172	ABC transporter signature motif; other site
258594005173	Walker B; other site
258594005174	D-loop; other site
258594005175	H-loop/switch region; other site
258594005176	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
258594005177	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594005178	Walker A/P-loop; other site
258594005179	ATP binding site [chemical binding]; other site
258594005180	Q-loop/lid; other site
258594005181	ABC transporter signature motif; other site
258594005182	Walker B; other site
258594005183	D-loop; other site
258594005184	H-loop/switch region; other site
258594005185	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
258594005186	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
258594005187	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
258594005188	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594005189	dimer interface [polypeptide binding]; other site
258594005190	conserved gate region; other site
258594005191	putative PBP binding loops; other site
258594005192	ABC-ATPase subunit interface; other site
258594005193	6 probable transmembrane helices predicted byTMHMM2.0
258594005194	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
258594005195	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594005196	dimer interface [polypeptide binding]; other site
258594005197	conserved gate region; other site
258594005198	putative PBP binding loops; other site
258594005199	ABC-ATPase subunit interface; other site
258594005200	6 probable transmembrane helices predicted byTMHMM2.0
258594005201	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
258594005202	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
258594005203	2 probable transmembrane helices predicted byTMHMM2.0
258594005204	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
258594005205	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
258594005206	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
258594005207	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594005208	dimer interface [polypeptide binding]; other site
258594005209	conserved gate region; other site
258594005210	ABC-ATPase subunit interface; other site
258594005211	6 probable transmembrane helices predicted byTMHMM2.0
258594005212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594005213	putative PBP binding loops; other site
258594005214	dimer interface [polypeptide binding]; other site
258594005215	ABC-ATPase subunit interface; other site
258594005216	6 probable transmembrane helices predicted byTMHMM2.0
258594005217	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
258594005218	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594005219	Walker A/P-loop; other site
258594005220	ATP binding site [chemical binding]; other site
258594005221	Q-loop/lid; other site
258594005222	ABC transporter signature motif; other site
258594005223	Walker B; other site
258594005224	D-loop; other site
258594005225	H-loop/switch region; other site
258594005226	TOBE domain; Region: TOBE_2; pfam08402
258594005227	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
258594005228	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
258594005229	active site
258594005230	metal binding site [ion binding]; metal-binding site
258594005231	hexamer interface [polypeptide binding]; other site
258594005232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005233	Response regulator receiver domain; Region: Response_reg; pfam00072
258594005234	active site
258594005235	phosphorylation site [posttranslational modification]
258594005236	intermolecular recognition site; other site
258594005237	dimerization interface [polypeptide binding]; other site
258594005238	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
258594005239	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
258594005240	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
258594005241	1 probable transmembrane helix predicted byTMHMM2.0
258594005242	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
258594005243	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
258594005244	phosphoglucomutase; Validated; Region: PRK07564
258594005245	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
258594005246	active site
258594005247	substrate binding site [chemical binding]; other site
258594005248	metal binding site [ion binding]; metal-binding site
258594005249	NnrU protein; Region: NnrU; pfam07298
258594005250	5 probable transmembrane helices predicted byTMHMM2.0
258594005251	NnrS protein; Region: NnrS; pfam05940
258594005252	12 probable transmembrane helices predicted byTMHMM2.0
258594005253	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
258594005254	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
258594005255	CoA-transferase family III; Region: CoA_transf_3; pfam02515
258594005256	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
258594005257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005258	active site
258594005259	phosphorylation site [posttranslational modification]
258594005260	intermolecular recognition site; other site
258594005261	dimerization interface [polypeptide binding]; other site
258594005262	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
258594005263	DNA binding residues [nucleotide binding]
258594005264	dimerization interface [polypeptide binding]; other site
258594005265	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
258594005266	GAF domain; Region: GAF; cl17456
258594005267	Phytochrome region; Region: PHY; pfam00360
258594005268	Histidine kinase; Region: HisKA_3; pfam07730
258594005269	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594005270	ATP binding site [chemical binding]; other site
258594005271	Mg2+ binding site [ion binding]; other site
258594005272	G-X-G motif; other site
258594005273	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
258594005274	1 probable transmembrane helix predicted byTMHMM2.0
258594005275	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
258594005276	1 probable transmembrane helix predicted byTMHMM2.0
258594005277	PUCC protein; Region: PUCC; pfam03209
258594005278	12 probable transmembrane helices predicted byTMHMM2.0
258594005279	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
258594005280	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
258594005281	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
258594005282	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594005283	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594005284	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
258594005285	Protein export membrane protein; Region: SecD_SecF; cl14618
258594005286	11 probable transmembrane helices predicted byTMHMM2.0
258594005287	2 probable transmembrane helices predicted byTMHMM2.0
258594005288	Domain of unknown function (DUF2383); Region: DUF2383; pfam09537
258594005289	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
258594005290	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
258594005291	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
258594005292	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
258594005293	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
258594005294	9 probable transmembrane helices predicted byTMHMM2.0
258594005295	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
258594005296	2 probable transmembrane helices predicted byTMHMM2.0
258594005297	Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181
258594005298	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
258594005299	domain interfaces; other site
258594005300	active site
258594005301	magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407
258594005302	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594005303	Walker A motif; other site
258594005304	ATP binding site [chemical binding]; other site
258594005305	Walker B motif; other site
258594005306	arginine finger; other site
258594005307	magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406
258594005308	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
258594005309	metal ion-dependent adhesion site (MIDAS); other site
258594005310	PilZ domain; Region: PilZ; pfam07238
258594005311	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
258594005312	substrate binding site [chemical binding]; other site
258594005313	active site
258594005314	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
258594005315	putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056
258594005316	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
258594005317	phytoene desaturase; Region: crtI_fam; TIGR02734
258594005318	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
258594005319	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
258594005320	active site lid residues [active]
258594005321	substrate binding pocket [chemical binding]; other site
258594005322	catalytic residues [active]
258594005323	substrate-Mg2+ binding site; other site
258594005324	aspartate-rich region 1; other site
258594005325	aspartate-rich region 2; other site
258594005326	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
258594005327	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
258594005328	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
258594005329	Ligand Binding Site [chemical binding]; other site
258594005330	1 probable transmembrane helix predicted byTMHMM2.0
258594005331	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
258594005332	phytoene desaturase; Region: crtI_fam; TIGR02734
258594005333	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
258594005334	1 probable transmembrane helix predicted byTMHMM2.0
258594005335	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
258594005336	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
258594005337	substrate binding pocket [chemical binding]; other site
258594005338	chain length determination region; other site
258594005339	substrate-Mg2+ binding site; other site
258594005340	catalytic residues [active]
258594005341	aspartate-rich region 1; other site
258594005342	active site lid residues [active]
258594005343	aspartate-rich region 2; other site
258594005344	O-methyltransferase; Region: Methyltransf_2; pfam00891
258594005345	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
258594005346	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
258594005347	putative NAD(P) binding site [chemical binding]; other site
258594005348	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
258594005349	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
258594005350	Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY).  Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980
258594005351	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
258594005352	1 probable transmembrane helix predicted byTMHMM2.0
258594005353	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
258594005354	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
258594005355	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
258594005356	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
258594005357	1 probable transmembrane helix predicted byTMHMM2.0
258594005358	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
258594005359	1 probable transmembrane helix predicted byTMHMM2.0
258594005360	Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290
258594005361	subunit M interface; other site
258594005362	subunit H interface; other site
258594005363	quinone binding site; other site
258594005364	bacteriopheophytin binding site; other site
258594005365	bacteriochlorophyll binding site; other site
258594005366	cytochrome C subunit interface; other site
258594005367	Fe binding site [ion binding]; other site
258594005368	5 probable transmembrane helices predicted byTMHMM2.0
258594005369	Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291
258594005370	subunit H interface; other site
258594005371	subunit L interface; other site
258594005372	bacteriopheophytin binding site; other site
258594005373	carotenoid binding site; other site
258594005374	bacteriochlorophyll binding site; other site
258594005375	cytochrome C interface; other site
258594005376	quinone binding site; other site
258594005377	Fe binding site [ion binding]; other site
258594005378	5 probable transmembrane helices predicted byTMHMM2.0
258594005379	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
258594005380	PAS domain; Region: PAS; smart00091
258594005381	putative active site [active]
258594005382	heme pocket [chemical binding]; other site
258594005383	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
258594005384	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
258594005385	UbiA prenyltransferase family; Region: UbiA; pfam01040
258594005386	8 probable transmembrane helices predicted byTMHMM2.0
258594005387	PUCC protein; Region: PUCC; pfam03209
258594005388	12 probable transmembrane helices predicted byTMHMM2.0
258594005389	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
258594005390	TspO/MBR family; Region: TspO_MBR; pfam03073
258594005391	5 probable transmembrane helices predicted byTMHMM2.0
258594005392	2 probable transmembrane helices predicted byTMHMM2.0
258594005393	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
258594005394	Cytochrome c; Region: Cytochrom_C; cl11414
258594005395	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
258594005396	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
258594005397	High identity to bacteriophytochrome from a photosynthetic Bradyrhizobium (strain ORS278) that controls photosystem synthesis.; Citation: Giraud E, Fardoux J, Fourrier N, Hannibal L, Genty B, Bouyer P, Dreyfus B, Vermeglio A. Bacteriophytochrome controls photosystem synthesis in anoxygenic bacteria. Nature. 2002 May 9;417(6885):202-5;Bacteriophytochrome, apparent pseudogene, frameshifted
258594005398	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
258594005399	heme binding pocket [chemical binding]; other site
258594005400	heme ligand [chemical binding]; other site
258594005401	B12 binding domain; Region: B12-binding_2; pfam02607
258594005402	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
258594005403	B12 binding site [chemical binding]; other site
258594005404	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
258594005405	4 probable transmembrane helices predicted byTMHMM2.0
258594005406	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
258594005407	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
258594005408	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
258594005409	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
258594005410	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
258594005411	magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405
258594005412	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
258594005413	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
258594005414	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
258594005415	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
258594005416	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
258594005417	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594005418	S-adenosylmethionine binding site [chemical binding]; other site
258594005419	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
258594005420	PUCC protein; Region: PUCC; pfam03209
258594005421	12 probable transmembrane helices predicted byTMHMM2.0
258594005422	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581
258594005423	photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150
258594005424	subunit M interaction residues [polypeptide binding]; other site
258594005425	subunit L interaction residues [polypeptide binding]; other site
258594005426	putative proton transfer pathway, P1; other site
258594005427	putative proton transfer pathway, P2; other site
258594005428	1 probable transmembrane helix predicted byTMHMM2.0
258594005429	Bacterial PH domain; Region: DUF304; pfam03703
258594005430	3 probable transmembrane helices predicted byTMHMM2.0
258594005431	putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054
258594005432	1 probable transmembrane helix predicted byTMHMM2.0
258594005433	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
258594005434	diiron binding motif [ion binding]; other site
258594005435	putative photosynthetic complex assembly protein 2; Region: photo_alph_chp2; TIGR03055
258594005436	6 probable transmembrane helices predicted byTMHMM2.0
258594005437	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
258594005438	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
258594005439	substrate-cofactor binding pocket; other site
258594005440	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594005441	catalytic residue [active]
258594005442	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594005443	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594005444	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
258594005445	putative dimerization interface [polypeptide binding]; other site
258594005446	Response regulator receiver domain; Region: Response_reg; pfam00072
258594005447	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005448	active site
258594005449	phosphorylation site [posttranslational modification]
258594005450	intermolecular recognition site; other site
258594005451	dimerization interface [polypeptide binding]; other site
258594005452	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
258594005453	putative binding surface; other site
258594005454	active site
258594005455	Response regulator receiver domain; Region: Response_reg; pfam00072
258594005456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005457	active site
258594005458	phosphorylation site [posttranslational modification]
258594005459	intermolecular recognition site; other site
258594005460	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594005461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005462	active site
258594005463	phosphorylation site [posttranslational modification]
258594005464	intermolecular recognition site; other site
258594005465	dimerization interface [polypeptide binding]; other site
258594005466	PAS domain S-box; Region: sensory_box; TIGR00229
258594005467	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594005468	putative active site [active]
258594005469	heme pocket [chemical binding]; other site
258594005470	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
258594005471	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594005472	putative active site [active]
258594005473	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594005474	dimer interface [polypeptide binding]; other site
258594005475	phosphorylation site [posttranslational modification]
258594005476	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594005477	ATP binding site [chemical binding]; other site
258594005478	Mg2+ binding site [ion binding]; other site
258594005479	G-X-G motif; other site
258594005480	Response regulator receiver domain; Region: Response_reg; pfam00072
258594005481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005482	active site
258594005483	phosphorylation site [posttranslational modification]
258594005484	intermolecular recognition site; other site
258594005485	dimerization interface [polypeptide binding]; other site
258594005486	3 probable transmembrane helices predicted byTMHMM2.0
258594005487	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
258594005488	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
258594005489	homodimer interface [polypeptide binding]; other site
258594005490	active site
258594005491	heterodimer interface [polypeptide binding]; other site
258594005492	catalytic residue [active]
258594005493	metal binding site [ion binding]; metal-binding site
258594005494	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
258594005495	multimerization interface [polypeptide binding]; other site
258594005496	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
258594005497	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594005498	Walker A motif; other site
258594005499	ATP binding site [chemical binding]; other site
258594005500	Walker B motif; other site
258594005501	arginine finger; other site
258594005502	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594005503	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594005504	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
258594005505	dimerization interface [polypeptide binding]; other site
258594005506	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
258594005507	Predicted amidohydrolase [General function prediction only]; Region: COG0388
258594005508	putative active site [active]
258594005509	catalytic triad [active]
258594005510	putative dimer interface [polypeptide binding]; other site
258594005511	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594005512	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
258594005513	putative ligand binding site [chemical binding]; other site
258594005514	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594005515	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594005516	TM-ABC transporter signature motif; other site
258594005517	8 probable transmembrane helices predicted byTMHMM2.0
258594005518	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594005519	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594005520	TM-ABC transporter signature motif; other site
258594005521	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594005522	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594005523	Walker A/P-loop; other site
258594005524	ATP binding site [chemical binding]; other site
258594005525	Q-loop/lid; other site
258594005526	ABC transporter signature motif; other site
258594005527	Walker B; other site
258594005528	D-loop; other site
258594005529	H-loop/switch region; other site
258594005530	8 probable transmembrane helices predicted byTMHMM2.0
258594005531	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594005532	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594005533	Walker A/P-loop; other site
258594005534	ATP binding site [chemical binding]; other site
258594005535	Q-loop/lid; other site
258594005536	ABC transporter signature motif; other site
258594005537	Walker B; other site
258594005538	D-loop; other site
258594005539	H-loop/switch region; other site
258594005540	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
258594005541	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
258594005542	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
258594005543	catalytic site [active]
258594005544	TAP-like protein; Region: Abhydrolase_4; pfam08386
258594005545	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
258594005546	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
258594005547	homodimer interface [polypeptide binding]; other site
258594005548	substrate-cofactor binding pocket; other site
258594005549	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594005550	catalytic residue [active]
258594005551	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
258594005552	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
258594005553	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
258594005554	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
258594005555	inhibitor site; inhibition site
258594005556	active site
258594005557	dimer interface [polypeptide binding]; other site
258594005558	catalytic residue [active]
258594005559	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
258594005560	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
258594005561	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
258594005562	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
258594005563	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
258594005564	Repair protein; Region: Repair_PSII; pfam04536
258594005565	4 probable transmembrane helices predicted byTMHMM2.0
258594005566	Repair protein; Region: Repair_PSII; pfam04536
258594005567	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
258594005568	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
258594005569	putative C-terminal domain interface [polypeptide binding]; other site
258594005570	putative GSH binding site (G-site) [chemical binding]; other site
258594005571	putative dimer interface [polypeptide binding]; other site
258594005572	C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182
258594005573	putative N-terminal domain interface [polypeptide binding]; other site
258594005574	putative dimer interface [polypeptide binding]; other site
258594005575	putative substrate binding pocket (H-site) [chemical binding]; other site
258594005576	1 probable transmembrane helix predicted byTMHMM2.0
258594005577	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
258594005578	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
258594005579	FAD binding pocket [chemical binding]; other site
258594005580	FAD binding motif [chemical binding]; other site
258594005581	phosphate binding motif [ion binding]; other site
258594005582	beta-alpha-beta structure motif; other site
258594005583	NAD binding pocket [chemical binding]; other site
258594005584	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
258594005585	CoA-transferase family III; Region: CoA_transf_3; pfam02515
258594005586	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
258594005587	Proline dehydrogenase; Region: Pro_dh; pfam01619
258594005588	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
258594005589	Glutamate binding site [chemical binding]; other site
258594005590	NAD binding site [chemical binding]; other site
258594005591	catalytic residues [active]
258594005592	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
258594005593	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
258594005594	catalytic loop [active]
258594005595	iron binding site [ion binding]; other site
258594005596	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
258594005597	cyclase homology domain; Region: CHD; cd07302
258594005598	nucleotidyl binding site; other site
258594005599	metal binding site [ion binding]; metal-binding site
258594005600	dimer interface [polypeptide binding]; other site
258594005601	6 probable transmembrane helices predicted byTMHMM2.0
258594005602	Domain of unknown function (DUF697); Region: DUF697; cl12064
258594005603	hypothetical protein; Provisional; Region: PRK05415
258594005604	3 probable transmembrane helices predicted byTMHMM2.0
258594005605	YcjX-like family, DUF463; Region: DUF463; pfam04317
258594005606	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
258594005607	7 probable transmembrane helices predicted byTMHMM2.0
258594005608	short chain dehydrogenase; Provisional; Region: PRK06181
258594005609	classical (c) SDRs; Region: SDR_c; cd05233
258594005610	NAD(P) binding site [chemical binding]; other site
258594005611	active site
258594005612	1 probable transmembrane helix predicted byTMHMM2.0
258594005613	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
258594005614	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
258594005615	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594005616	catalytic residue [active]
258594005617	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
258594005618	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
258594005619	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
258594005620	RNA binding surface [nucleotide binding]; other site
258594005621	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
258594005622	Cupin domain; Region: Cupin_2; pfam07883
258594005623	1 probable transmembrane helix predicted byTMHMM2.0
258594005624	glutamate racemase; Provisional; Region: PRK00865
258594005625	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
258594005626	CoenzymeA binding site [chemical binding]; other site
258594005627	subunit interaction site [polypeptide binding]; other site
258594005628	PHB binding site; other site
258594005629	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
258594005630	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
258594005631	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594005632	catalytic residue [active]
258594005633	TIR domain; Region: TIR_2; pfam13676
258594005634	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
258594005635	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
258594005636	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
258594005637	dimerization interface [polypeptide binding]; other site
258594005638	ATP binding site [chemical binding]; other site
258594005639	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
258594005640	dimerization interface [polypeptide binding]; other site
258594005641	ATP binding site [chemical binding]; other site
258594005642	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
258594005643	Acyltransferase family; Region: Acyl_transf_3; pfam01757
258594005644	9 probable transmembrane helices predicted byTMHMM2.0
258594005645	Domain of unknown function (DUF427); Region: DUF427; pfam04248
258594005646	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
258594005647	MarR family; Region: MarR_2; pfam12802
258594005648	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
258594005649	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
258594005650	putative di-iron ligands [ion binding]; other site
258594005651	5 probable transmembrane helices predicted byTMHMM2.0
258594005652	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
258594005653	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
258594005654	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
258594005655	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
258594005656	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
258594005657	putative GSH binding site [chemical binding]; other site
258594005658	catalytic residues [active]
258594005659	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
258594005660	putative ADP-ribose binding site [chemical binding]; other site
258594005661	putative active site [active]
258594005662	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
258594005663	Beta-lactamase; Region: Beta-lactamase; pfam00144
258594005664	benzoylformate decarboxylase; Reviewed; Region: PRK07092
258594005665	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
258594005666	PYR/PP interface [polypeptide binding]; other site
258594005667	dimer interface [polypeptide binding]; other site
258594005668	TPP binding site [chemical binding]; other site
258594005669	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
258594005670	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
258594005671	TPP-binding site [chemical binding]; other site
258594005672	dimer interface [polypeptide binding]; other site
258594005673	Uncharacterized conserved protein [Function unknown]; Region: COG3777
258594005674	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
258594005675	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
258594005676	active site 2 [active]
258594005677	active site 1 [active]
258594005678	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
258594005679	CoA-transferase family III; Region: CoA_transf_3; pfam02515
258594005680	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594005681	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594005682	active site
258594005683	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
258594005684	Cytochrome P450; Region: p450; cl12078
258594005685	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
258594005686	isovaleryl-CoA dehydrogenase; Region: PLN02519
258594005687	substrate binding site [chemical binding]; other site
258594005688	FAD binding site [chemical binding]; other site
258594005689	catalytic base [active]
258594005690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594005691	S-adenosylmethionine binding site [chemical binding]; other site
258594005692	Protein of unknown function (DUF2927); Region: DUF2927; pfam11150
258594005693	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
258594005694	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
258594005695	hypothetical protein; Validated; Region: PRK07586
258594005696	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
258594005697	PYR/PP interface [polypeptide binding]; other site
258594005698	dimer interface [polypeptide binding]; other site
258594005699	TPP binding site [chemical binding]; other site
258594005700	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
258594005701	TPP-binding site [chemical binding]; other site
258594005702	dimer interface [polypeptide binding]; other site
258594005703	4 probable transmembrane helices predicted byTMHMM2.0
258594005704	1 probable transmembrane helix predicted byTMHMM2.0
258594005705	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
258594005706	1 probable transmembrane helix predicted byTMHMM2.0
258594005707	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
258594005708	1 probable transmembrane helix predicted byTMHMM2.0
258594005709	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
258594005710	1 probable transmembrane helix predicted byTMHMM2.0
258594005711	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
258594005712	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
258594005713	active site
258594005714	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
258594005715	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
258594005716	putative binding surface; other site
258594005717	active site
258594005718	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
258594005719	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
258594005720	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594005721	ATP binding site [chemical binding]; other site
258594005722	Mg2+ binding site [ion binding]; other site
258594005723	G-X-G motif; other site
258594005724	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
258594005725	CheW-like domain; Region: CheW; pfam01584
258594005726	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594005727	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005728	active site
258594005729	phosphorylation site [posttranslational modification]
258594005730	intermolecular recognition site; other site
258594005731	dimerization interface [polypeptide binding]; other site
258594005732	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
258594005733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005734	Response regulator receiver domain; Region: Response_reg; pfam00072
258594005735	active site
258594005736	phosphorylation site [posttranslational modification]
258594005737	intermolecular recognition site; other site
258594005738	dimerization interface [polypeptide binding]; other site
258594005739	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
258594005740	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005741	active site
258594005742	phosphorylation site [posttranslational modification]
258594005743	intermolecular recognition site; other site
258594005744	dimerization interface [polypeptide binding]; other site
258594005745	CheB methylesterase; Region: CheB_methylest; pfam01339
258594005746	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
258594005747	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
258594005748	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
258594005749	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
258594005750	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005751	active site
258594005752	phosphorylation site [posttranslational modification]
258594005753	intermolecular recognition site; other site
258594005754	dimerization interface [polypeptide binding]; other site
258594005755	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
258594005756	DNA binding site [nucleotide binding]
258594005757	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
258594005758	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
258594005759	Walker A motif/ATP binding site; other site
258594005760	Walker B motif; other site
258594005761	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
258594005762	RNA polymerase sigma factor; Provisional; Region: PRK12514
258594005763	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594005764	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
258594005765	DNA binding residues [nucleotide binding]
258594005766	Anti-sigma-K factor rskA; Region: RskA; pfam10099
258594005767	1 probable transmembrane helix predicted byTMHMM2.0
258594005768	1 probable transmembrane helix predicted byTMHMM2.0
258594005769	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
258594005770	FHIPEP family; Region: FHIPEP; pfam00771
258594005771	6 probable transmembrane helices predicted byTMHMM2.0
258594005772	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594005773	Major Facilitator Superfamily; Region: MFS_1; pfam07690
258594005774	putative substrate translocation pore; other site
258594005775	12 probable transmembrane helices predicted byTMHMM2.0
258594005776	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
258594005777	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594005778	dimer interface [polypeptide binding]; other site
258594005779	putative CheW interface [polypeptide binding]; other site
258594005780	2 probable transmembrane helices predicted byTMHMM2.0
258594005781	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
258594005782	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594005783	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594005784	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594005785	metal binding site [ion binding]; metal-binding site
258594005786	active site
258594005787	I-site; other site
258594005788	Hemerythrin; Region: Hemerythrin; cd12107
258594005789	Fe binding site [ion binding]; other site
258594005790	Iron permease FTR1 family; Region: FTR1; cl00475
258594005791	7 probable transmembrane helices predicted byTMHMM2.0
258594005792	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
258594005793	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
258594005794	Protein of unknown function (DUF3222); Region: DUF3222; pfam11519
258594005795	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
258594005796	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
258594005797	catalytic site [active]
258594005798	1 probable transmembrane helix predicted byTMHMM2.0
258594005799	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594005800	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
258594005801	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594005802	1 probable transmembrane helix predicted byTMHMM2.0
258594005803	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
258594005804	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
258594005805	FtsX-like permease family; Region: FtsX; pfam02687
258594005806	4 probable transmembrane helices predicted byTMHMM2.0
258594005807	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
258594005808	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
258594005809	Walker A/P-loop; other site
258594005810	ATP binding site [chemical binding]; other site
258594005811	Q-loop/lid; other site
258594005812	ABC transporter signature motif; other site
258594005813	Walker B; other site
258594005814	D-loop; other site
258594005815	H-loop/switch region; other site
258594005816	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
258594005817	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594005818	putative ligand binding site [chemical binding]; other site
258594005819	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
258594005820	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
258594005821	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
258594005822	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
258594005823	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
258594005824	active site
258594005825	catalytic tetrad [active]
258594005826	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594005827	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
258594005828	putative ligand binding site [chemical binding]; other site
258594005829	5 probable transmembrane helices predicted byTMHMM2.0
258594005830	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594005831	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594005832	metal binding site [ion binding]; metal-binding site
258594005833	active site
258594005834	I-site; other site
258594005835	7 probable transmembrane helices predicted byTMHMM2.0
258594005836	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
258594005837	active site
258594005838	Hemerythrin-like domain; Region: Hr-like; cd12108
258594005839	Fe binding site [ion binding]; other site
258594005840	YHS domain; Region: YHS; pfam04945
258594005841	YHS domain; Region: YHS; pfam04945
258594005842	Uncharacterized conserved protein [Function unknown]; Region: COG3350
258594005843	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
258594005844	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
258594005845	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594005846	motif II; other site
258594005847	8 probable transmembrane helices predicted byTMHMM2.0
258594005848	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
258594005849	putative homodimer interface [polypeptide binding]; other site
258594005850	putative homotetramer interface [polypeptide binding]; other site
258594005851	putative allosteric switch controlling residues; other site
258594005852	putative metal binding site [ion binding]; other site
258594005853	putative homodimer-homodimer interface [polypeptide binding]; other site
258594005854	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
258594005855	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
258594005856	putative active site [active]
258594005857	putative metal binding site [ion binding]; other site
258594005858	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
258594005859	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
258594005860	Zn binding site [ion binding]; other site
258594005861	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
258594005862	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594005863	FeS/SAM binding site; other site
258594005864	HemN C-terminal domain; Region: HemN_C; pfam06969
258594005865	V4R domain; Region: V4R; cl15268
258594005866	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
258594005867	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
258594005868	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594005869	FeS/SAM binding site; other site
258594005870	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
258594005871	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
258594005872	active site
258594005873	metal binding site [ion binding]; metal-binding site
258594005874	Protein kinase domain; Region: Pkinase; pfam00069
258594005875	Catalytic domain of Protein Kinases; Region: PKc; cd00180
258594005876	active site
258594005877	ATP binding site [chemical binding]; other site
258594005878	substrate binding site [chemical binding]; other site
258594005879	activation loop (A-loop); other site
258594005880	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
258594005881	Ligand Binding Site [chemical binding]; other site
258594005882	BON domain; Region: BON; pfam04972
258594005883	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
258594005884	BON domain; Region: BON; pfam04972
258594005885	BON domain; Region: BON; pfam04972
258594005886	putative phosphoketolase; Provisional; Region: PRK05261
258594005887	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
258594005888	TPP-binding site; other site
258594005889	XFP C-terminal domain; Region: XFP_C; pfam09363
258594005890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005891	Response regulator receiver domain; Region: Response_reg; pfam00072
258594005892	active site
258594005893	phosphorylation site [posttranslational modification]
258594005894	intermolecular recognition site; other site
258594005895	dimerization interface [polypeptide binding]; other site
258594005896	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594005897	PAS domain; Region: PAS_9; pfam13426
258594005898	putative active site [active]
258594005899	heme pocket [chemical binding]; other site
258594005900	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
258594005901	Tar ligand binding domain homologue; Region: TarH; pfam02203
258594005902	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
258594005903	dimerization interface [polypeptide binding]; other site
258594005904	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594005905	dimer interface [polypeptide binding]; other site
258594005906	putative CheW interface [polypeptide binding]; other site
258594005907	2 probable transmembrane helices predicted byTMHMM2.0
258594005908	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
258594005909	putative binding surface; other site
258594005910	active site
258594005911	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
258594005912	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
258594005913	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594005914	ATP binding site [chemical binding]; other site
258594005915	Mg2+ binding site [ion binding]; other site
258594005916	G-X-G motif; other site
258594005917	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
258594005918	CheW-like domain; Region: CheW; pfam01584
258594005919	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594005920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005921	active site
258594005922	phosphorylation site [posttranslational modification]
258594005923	intermolecular recognition site; other site
258594005924	dimerization interface [polypeptide binding]; other site
258594005925	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
258594005926	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
258594005927	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
258594005928	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
258594005929	Response regulator receiver domain; Region: Response_reg; pfam00072
258594005930	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005931	active site
258594005932	phosphorylation site [posttranslational modification]
258594005933	intermolecular recognition site; other site
258594005934	dimerization interface [polypeptide binding]; other site
258594005935	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594005936	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594005937	dimer interface [polypeptide binding]; other site
258594005938	phosphorylation site [posttranslational modification]
258594005939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594005940	ATP binding site [chemical binding]; other site
258594005941	Mg2+ binding site [ion binding]; other site
258594005942	G-X-G motif; other site
258594005943	Response regulator receiver domain; Region: Response_reg; pfam00072
258594005944	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005945	active site
258594005946	phosphorylation site [posttranslational modification]
258594005947	intermolecular recognition site; other site
258594005948	dimerization interface [polypeptide binding]; other site
258594005949	Hpt domain; Region: Hpt; pfam01627
258594005950	putative binding surface; other site
258594005951	active site
258594005952	2 probable transmembrane helices predicted byTMHMM2.0
258594005953	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
258594005954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594005955	active site
258594005956	phosphorylation site [posttranslational modification]
258594005957	intermolecular recognition site; other site
258594005958	dimerization interface [polypeptide binding]; other site
258594005959	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
258594005960	DNA binding residues [nucleotide binding]
258594005961	dimerization interface [polypeptide binding]; other site
258594005962	short chain dehydrogenase; Provisional; Region: PRK08339
258594005963	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
258594005964	putative NAD(P) binding site [chemical binding]; other site
258594005965	putative active site [active]
258594005966	short chain dehydrogenase; Provisional; Region: PRK06949
258594005967	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594005968	NAD(P) binding site [chemical binding]; other site
258594005969	active site
258594005970	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
258594005971	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
258594005972	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
258594005973	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
258594005974	Autotransporter beta-domain; Region: Autotransporter; smart00869
258594005975	choline dehydrogenase; Validated; Region: PRK02106
258594005976	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
258594005977	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
258594005978	NAD(P) binding site [chemical binding]; other site
258594005979	catalytic residues [active]
258594005980	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
258594005981	Coenzyme A binding pocket [chemical binding]; other site
258594005982	Protein of unknown function (DUF3095); Region: DUF3095; pfam11294
258594005983	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
258594005984	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
258594005985	putative efflux protein, MATE family; Region: matE; TIGR00797
258594005986	12 probable transmembrane helices predicted byTMHMM2.0
258594005987	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594005988	Major Facilitator Superfamily; Region: MFS_1; pfam07690
258594005989	putative substrate translocation pore; other site
258594005990	12 probable transmembrane helices predicted byTMHMM2.0
258594005991	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
258594005992	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
258594005993	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
258594005994	camphor resistance protein CrcB; Provisional; Region: PRK14198
258594005995	4 probable transmembrane helices predicted byTMHMM2.0
258594005996	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
258594005997	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
258594005998	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594005999	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
258594006000	Competence-damaged protein; Region: CinA; pfam02464
258594006001	1 probable transmembrane helix predicted byTMHMM2.0
258594006002	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
258594006003	8 probable transmembrane helices predicted byTMHMM2.0
258594006004	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594006005	active site
258594006006	amidase; Provisional; Region: PRK06170
258594006007	Amidase; Region: Amidase; cl11426
258594006008	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594006009	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
258594006010	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
258594006011	acyl-activating enzyme (AAE) consensus motif; other site
258594006012	putative AMP binding site [chemical binding]; other site
258594006013	putative active site [active]
258594006014	acyl-activating enzyme (AAE) consensus motif; other site
258594006015	putative CoA binding site [chemical binding]; other site
258594006016	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
258594006017	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
258594006018	dimer interface [polypeptide binding]; other site
258594006019	active site
258594006020	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594006021	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594006022	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
258594006023	NAD binding site [chemical binding]; other site
258594006024	homodimer interface [polypeptide binding]; other site
258594006025	homotetramer interface [polypeptide binding]; other site
258594006026	active site
258594006027	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
258594006028	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594006029	substrate binding site [chemical binding]; other site
258594006030	oxyanion hole (OAH) forming residues; other site
258594006031	trimer interface [polypeptide binding]; other site
258594006032	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
258594006033	acyl-CoA synthetase; Provisional; Region: PRK12582
258594006034	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
258594006035	acyl-activating enzyme (AAE) consensus motif; other site
258594006036	putative AMP binding site [chemical binding]; other site
258594006037	putative active site [active]
258594006038	putative CoA binding site [chemical binding]; other site
258594006039	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594006040	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594006041	active site
258594006042	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594006043	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
258594006044	FAD binding site [chemical binding]; other site
258594006045	substrate binding site [chemical binding]; other site
258594006046	catalytic base [active]
258594006047	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594006048	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
258594006049	FAD binding site [chemical binding]; other site
258594006050	substrate binding site [chemical binding]; other site
258594006051	catalytic base [active]
258594006052	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
258594006053	putative FMN binding site [chemical binding]; other site
258594006054	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594006055	enoyl-CoA hydratase; Provisional; Region: PRK05995
258594006056	substrate binding site [chemical binding]; other site
258594006057	oxyanion hole (OAH) forming residues; other site
258594006058	trimer interface [polypeptide binding]; other site
258594006059	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594006060	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594006061	ligand binding site [chemical binding]; other site
258594006062	flexible hinge region; other site
258594006063	2 probable transmembrane helices predicted byTMHMM2.0
258594006064	putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312
258594006065	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
258594006066	2 probable transmembrane helices predicted byTMHMM2.0
258594006067	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
258594006068	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594006069	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594006070	metal binding site [ion binding]; metal-binding site
258594006071	active site
258594006072	I-site; other site
258594006073	9 probable transmembrane helices predicted byTMHMM2.0
258594006074	Flagellin N-methylase; Region: FliB; cl00497
258594006075	Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576
258594006076	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594006077	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594006078	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
258594006079	putative effector binding pocket; other site
258594006080	putative dimerization interface [polypeptide binding]; other site
258594006081	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
258594006082	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594006083	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
258594006084	acyl-activating enzyme (AAE) consensus motif; other site
258594006085	AMP binding site [chemical binding]; other site
258594006086	active site
258594006087	CoA binding site [chemical binding]; other site
258594006088	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
258594006089	CoenzymeA binding site [chemical binding]; other site
258594006090	subunit interaction site [polypeptide binding]; other site
258594006091	PHB binding site; other site
258594006092	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
258594006093	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
258594006094	substrate binding site [chemical binding]; other site
258594006095	dimer interface [polypeptide binding]; other site
258594006096	NADP binding site [chemical binding]; other site
258594006097	catalytic residues [active]
258594006098	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
258594006099	substrate binding site [chemical binding]; other site
258594006100	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
258594006101	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
258594006102	NAD(P) binding site [chemical binding]; other site
258594006103	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
258594006104	Fatty acid desaturase; Region: FA_desaturase; pfam00487
258594006105	putative di-iron ligands [ion binding]; other site
258594006106	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
258594006107	3 probable transmembrane helices predicted byTMHMM2.0
258594006108	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
258594006109	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
258594006110	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
258594006111	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
258594006112	Moco binding site; other site
258594006113	metal coordination site [ion binding]; other site
258594006114	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
258594006115	Cytochrome P450; Region: p450; cl12078
258594006116	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
258594006117	amidase; Provisional; Region: PRK07486
258594006118	Amidase; Region: Amidase; pfam01425
258594006119	pseudogene of fused ABC transporter ATPase and permease domains
258594006120	4 probable transmembrane helices predicted byTMHMM2.0
258594006121	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
258594006122	beta-galactosidase; Region: BGL; TIGR03356
258594006123	short chain dehydrogenase; Provisional; Region: PRK06125
258594006124	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594006125	NAD(P) binding site [chemical binding]; other site
258594006126	active site
258594006127	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594006128	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594006129	Walker A/P-loop; other site
258594006130	ATP binding site [chemical binding]; other site
258594006131	Q-loop/lid; other site
258594006132	ABC transporter signature motif; other site
258594006133	Walker B; other site
258594006134	D-loop; other site
258594006135	H-loop/switch region; other site
258594006136	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594006137	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594006138	Walker A/P-loop; other site
258594006139	ATP binding site [chemical binding]; other site
258594006140	Q-loop/lid; other site
258594006141	ABC transporter signature motif; other site
258594006142	Walker B; other site
258594006143	D-loop; other site
258594006144	H-loop/switch region; other site
258594006145	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594006146	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594006147	TM-ABC transporter signature motif; other site
258594006148	9 probable transmembrane helices predicted byTMHMM2.0
258594006149	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594006150	TM-ABC transporter signature motif; other site
258594006151	8 probable transmembrane helices predicted byTMHMM2.0
258594006152	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594006153	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_10; cd06345
258594006154	putative ligand binding site [chemical binding]; other site
258594006155	tartrate dehydrogenase; Region: TTC; TIGR02089
258594006156	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
258594006157	2 probable transmembrane helices predicted byTMHMM2.0
258594006158	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
258594006159	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
258594006160	NAD binding site [chemical binding]; other site
258594006161	allantoate amidohydrolase; Reviewed; Region: PRK09290
258594006162	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
258594006163	active site
258594006164	metal binding site [ion binding]; metal-binding site
258594006165	dimer interface [polypeptide binding]; other site
258594006166	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594006167	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594006168	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
258594006169	dimerization interface [polypeptide binding]; other site
258594006170	hypothetical protein; Provisional; Region: PRK05463
258594006171	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
258594006172	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340
258594006173	putative ligand binding site [chemical binding]; other site
258594006174	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594006175	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594006176	TM-ABC transporter signature motif; other site
258594006177	8 probable transmembrane helices predicted byTMHMM2.0
258594006178	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594006179	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594006180	TM-ABC transporter signature motif; other site
258594006181	9 probable transmembrane helices predicted byTMHMM2.0
258594006182	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594006183	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594006184	Walker A/P-loop; other site
258594006185	ATP binding site [chemical binding]; other site
258594006186	Q-loop/lid; other site
258594006187	ABC transporter signature motif; other site
258594006188	Walker B; other site
258594006189	D-loop; other site
258594006190	H-loop/switch region; other site
258594006191	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594006192	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594006193	Walker A/P-loop; other site
258594006194	ATP binding site [chemical binding]; other site
258594006195	Q-loop/lid; other site
258594006196	ABC transporter signature motif; other site
258594006197	Walker B; other site
258594006198	D-loop; other site
258594006199	H-loop/switch region; other site
258594006200	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
258594006201	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
258594006202	12 probable transmembrane helices predicted byTMHMM2.0
258594006203	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594006204	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594006205	1 probable transmembrane helix predicted byTMHMM2.0
258594006206	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
258594006207	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
258594006208	active site
258594006209	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
258594006210	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594006211	NAD(P) binding site [chemical binding]; other site
258594006212	active site
258594006213	enoyl-CoA hydratase; Provisional; Region: PRK05981
258594006214	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594006215	substrate binding site [chemical binding]; other site
258594006216	oxyanion hole (OAH) forming residues; other site
258594006217	trimer interface [polypeptide binding]; other site
258594006218	Phosphotransferase enzyme family; Region: APH; pfam01636
258594006219	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
258594006220	putative active site [active]
258594006221	putative substrate binding site [chemical binding]; other site
258594006222	ATP binding site [chemical binding]; other site
258594006223	alpha-amylase/limit dextrinase; Region: PLN02877
258594006224	enoyl-CoA hydratase; Provisional; Region: PRK06494
258594006225	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594006226	substrate binding site [chemical binding]; other site
258594006227	oxyanion hole (OAH) forming residues; other site
258594006228	trimer interface [polypeptide binding]; other site
258594006229	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594006230	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
258594006231	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
258594006232	active site
258594006233	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
258594006234	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594006235	acyl-activating enzyme (AAE) consensus motif; other site
258594006236	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
258594006237	acyl-activating enzyme (AAE) consensus motif; other site
258594006238	putative AMP binding site [chemical binding]; other site
258594006239	putative active site [active]
258594006240	putative CoA binding site [chemical binding]; other site
258594006241	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
258594006242	short chain dehydrogenase; Provisional; Region: PRK07677
258594006243	NAD(P) binding site [chemical binding]; other site
258594006244	substrate binding site [chemical binding]; other site
258594006245	homotetramer interface [polypeptide binding]; other site
258594006246	active site
258594006247	homodimer interface [polypeptide binding]; other site
258594006248	enoyl-CoA hydratase; Provisional; Region: PRK07509
258594006249	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594006250	substrate binding site [chemical binding]; other site
258594006251	oxyanion hole (OAH) forming residues; other site
258594006252	trimer interface [polypeptide binding]; other site
258594006253	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406
258594006254	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594006255	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
258594006256	acyl-activating enzyme (AAE) consensus motif; other site
258594006257	acyl-activating enzyme (AAE) consensus motif; other site
258594006258	putative AMP binding site [chemical binding]; other site
258594006259	putative active site [active]
258594006260	putative CoA binding site [chemical binding]; other site
258594006261	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
258594006262	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594006263	dimer interface [polypeptide binding]; other site
258594006264	phosphorylation site [posttranslational modification]
258594006265	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594006266	ATP binding site [chemical binding]; other site
258594006267	G-X-G motif; other site
258594006268	Response regulator receiver domain; Region: Response_reg; pfam00072
258594006269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594006270	active site
258594006271	phosphorylation site [posttranslational modification]
258594006272	intermolecular recognition site; other site
258594006273	dimerization interface [polypeptide binding]; other site
258594006274	1 probable transmembrane helix predicted byTMHMM2.0
258594006275	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
258594006276	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594006277	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
258594006278	putative dimerization interface [polypeptide binding]; other site
258594006279	Predicted membrane protein [Function unknown]; Region: COG2855
258594006280	10 probable transmembrane helices predicted byTMHMM2.0
258594006281	6 probable transmembrane helices predicted byTMHMM2.0
258594006282	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
258594006283	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
258594006284	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
258594006285	3 probable transmembrane helices predicted byTMHMM2.0
258594006286	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
258594006287	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
258594006288	ligand binding site [chemical binding]; other site
258594006289	4 probable transmembrane helices predicted byTMHMM2.0
258594006290	short chain dehydrogenase; Provisional; Region: PRK07791
258594006291	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594006292	NAD(P) binding site [chemical binding]; other site
258594006293	active site
258594006294	thiolase; Provisional; Region: PRK06158
258594006295	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
258594006296	active site
258594006297	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
258594006298	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
258594006299	DUF35 OB-fold domain; Region: DUF35; pfam01796
258594006300	amidase; Provisional; Region: PRK07056
258594006301	Amidase; Region: Amidase; cl11426
258594006302	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
258594006303	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
258594006304	CoenzymeA binding site [chemical binding]; other site
258594006305	subunit interaction site [polypeptide binding]; other site
258594006306	PHB binding site; other site
258594006307	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
258594006308	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
258594006309	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
258594006310	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
258594006311	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
258594006312	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
258594006313	4 probable transmembrane helices predicted byTMHMM2.0
258594006314	DctM-like transporters; Region: DctM; pfam06808
258594006315	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
258594006316	11 probable transmembrane helices predicted byTMHMM2.0
258594006317	hypothetical protein; Provisional; Region: PRK00872
258594006318	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
258594006319	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594006320	substrate binding site [chemical binding]; other site
258594006321	oxyanion hole (OAH) forming residues; other site
258594006322	trimer interface [polypeptide binding]; other site
258594006323	feruloyl-CoA synthase; Reviewed; Region: PRK08180
258594006324	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
258594006325	acyl-activating enzyme (AAE) consensus motif; other site
258594006326	putative AMP binding site [chemical binding]; other site
258594006327	putative active site [active]
258594006328	putative CoA binding site [chemical binding]; other site
258594006329	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
258594006330	active site
258594006331	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
258594006332	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
258594006333	putative ligand binding site [chemical binding]; other site
258594006334	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594006335	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594006336	metal binding site [ion binding]; metal-binding site
258594006337	active site
258594006338	I-site; other site
258594006339	2 probable transmembrane helices predicted byTMHMM2.0
258594006340	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594006341	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594006342	Walker A/P-loop; other site
258594006343	ATP binding site [chemical binding]; other site
258594006344	Q-loop/lid; other site
258594006345	ABC transporter signature motif; other site
258594006346	Walker B; other site
258594006347	D-loop; other site
258594006348	H-loop/switch region; other site
258594006349	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594006350	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594006351	TM-ABC transporter signature motif; other site
258594006352	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594006353	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594006354	Walker A/P-loop; other site
258594006355	ATP binding site [chemical binding]; other site
258594006356	Q-loop/lid; other site
258594006357	ABC transporter signature motif; other site
258594006358	Walker B; other site
258594006359	D-loop; other site
258594006360	H-loop/switch region; other site
258594006361	9 probable transmembrane helices predicted byTMHMM2.0
258594006362	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594006363	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594006364	TM-ABC transporter signature motif; other site
258594006365	9 probable transmembrane helices predicted byTMHMM2.0
258594006366	Transcriptional regulators [Transcription]; Region: MarR; COG1846
258594006367	MarR family; Region: MarR; pfam01047
258594006368	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
258594006369	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
258594006370	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
258594006371	TrkA-N domain; Region: TrkA_N; pfam02254
258594006372	9 probable transmembrane helices predicted byTMHMM2.0
258594006373	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
258594006374	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
258594006375	cyclase homology domain; Region: CHD; cd07302
258594006376	nucleotidyl binding site; other site
258594006377	metal binding site [ion binding]; metal-binding site
258594006378	dimer interface [polypeptide binding]; other site
258594006379	2 probable transmembrane helices predicted byTMHMM2.0
258594006380	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
258594006381	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
258594006382	MOFRL family; Region: MOFRL; pfam05161
258594006383	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
258594006384	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594006385	putative ligand binding site [chemical binding]; other site
258594006386	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
258594006387	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
258594006388	Fe-S cluster binding site [ion binding]; other site
258594006389	active site
258594006390	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
258594006391	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594006392	FeS/SAM binding site; other site
258594006393	Uncharacterized conserved protein [Function unknown]; Region: COG4544
258594006394	DNA Polymerase Y-family; Region: PolY_like; cd03468
258594006395	active site
258594006396	DNA binding site [nucleotide binding]
258594006397	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
258594006398	active site
258594006399	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
258594006400	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
258594006401	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
258594006402	generic binding surface I; other site
258594006403	generic binding surface II; other site
258594006404	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594006405	NAD(P) binding site [chemical binding]; other site
258594006406	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
258594006407	active site
258594006408	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594006409	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594006410	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
258594006411	substrate binding pocket [chemical binding]; other site
258594006412	dimerization interface [polypeptide binding]; other site
258594006413	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
258594006414	CoA-transferase family III; Region: CoA_transf_3; pfam02515
258594006415	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
258594006416	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
258594006417	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594006418	1 probable transmembrane helix predicted byTMHMM2.0
258594006419	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
258594006420	12 probable transmembrane helices predicted byTMHMM2.0
258594006421	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
258594006422	enoyl-CoA hydratase; Provisional; Region: PRK05862
258594006423	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594006424	substrate binding site [chemical binding]; other site
258594006425	oxyanion hole (OAH) forming residues; other site
258594006426	trimer interface [polypeptide binding]; other site
258594006427	2 probable transmembrane helices predicted byTMHMM2.0
258594006428	RNA polymerase sigma factor; Provisional; Region: PRK12512
258594006429	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594006430	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
258594006431	DNA binding residues [nucleotide binding]
258594006432	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
258594006433	6 probable transmembrane helices predicted byTMHMM2.0
258594006434	1 probable transmembrane helix predicted byTMHMM2.0
258594006435	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
258594006436	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594006437	N-terminal plug; other site
258594006438	ligand-binding site [chemical binding]; other site
258594006439	1 probable transmembrane helix predicted byTMHMM2.0
258594006440	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
258594006441	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594006442	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594006443	metal binding site [ion binding]; metal-binding site
258594006444	active site
258594006445	I-site; other site
258594006446	6 probable transmembrane helices predicted byTMHMM2.0
258594006447	RNA polymerase sigma factor; Provisional; Region: PRK12515
258594006448	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594006449	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
258594006450	DNA binding residues [nucleotide binding]
258594006451	TIGR03809 family protein; Region: TIGR03809
258594006452	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
258594006453	HAMP domain; Region: HAMP; pfam00672
258594006454	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594006455	dimer interface [polypeptide binding]; other site
258594006456	putative CheW interface [polypeptide binding]; other site
258594006457	2 probable transmembrane helices predicted byTMHMM2.0
258594006458	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
258594006459	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
258594006460	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
258594006461	dimerization interface [polypeptide binding]; other site
258594006462	PilZ domain; Region: PilZ; pfam07238
258594006463	twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808
258594006464	putative cofactor-binding repeat; Region: RR_fam_repeat; TIGR03807
258594006465	putative cofactor-binding repeat; Region: RR_fam_repeat; TIGR03807
258594006466	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
258594006467	putative substrate binding pocket [chemical binding]; other site
258594006468	AC domain interface; other site
258594006469	catalytic triad [active]
258594006470	AB domain interface; other site
258594006471	interchain disulfide; other site
258594006472	membrane ATPase/protein kinase; Provisional; Region: PRK09435
258594006473	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
258594006474	Walker A; other site
258594006475	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
258594006476	G4 box; other site
258594006477	G5 box; other site
258594006478	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
258594006479	zinc binding site [ion binding]; other site
258594006480	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
258594006481	active site clefts [active]
258594006482	zinc binding site [ion binding]; other site
258594006483	dimer interface [polypeptide binding]; other site
258594006484	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
258594006485	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
258594006486	putative active site [active]
258594006487	homotetrameric interface [polypeptide binding]; other site
258594006488	metal binding site [ion binding]; metal-binding site
258594006489	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
258594006490	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
258594006491	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
258594006492	active site
258594006493	substrate binding site [chemical binding]; other site
258594006494	coenzyme B12 binding site [chemical binding]; other site
258594006495	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
258594006496	B12 binding site [chemical binding]; other site
258594006497	cobalt ligand [ion binding]; other site
258594006498	Uncharacterized conserved protein [Function unknown]; Region: COG3791
258594006499	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
258594006500	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
258594006501	heterodimer interface [polypeptide binding]; other site
258594006502	substrate interaction site [chemical binding]; other site
258594006503	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
258594006504	catalytic center binding site [active]
258594006505	ATP binding site [chemical binding]; other site
258594006506	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
258594006507	homooctamer interface [polypeptide binding]; other site
258594006508	active site
258594006509	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
258594006510	dihydropteroate synthase; Region: DHPS; TIGR01496
258594006511	substrate binding pocket [chemical binding]; other site
258594006512	dimer interface [polypeptide binding]; other site
258594006513	inhibitor binding site; inhibition site
258594006514	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
258594006515	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
258594006516	Zonular occludens toxin (Zot); Region: Zot; cl17485
258594006517	hypothetical protein; Validated; Region: PRK09104
258594006518	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
258594006519	metal binding site [ion binding]; metal-binding site
258594006520	putative dimer interface [polypeptide binding]; other site
258594006521	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
258594006522	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594006523	N-terminal plug; other site
258594006524	ligand-binding site [chemical binding]; other site
258594006525	1 probable transmembrane helix predicted byTMHMM2.0
258594006526	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
258594006527	3 probable transmembrane helices predicted byTMHMM2.0
258594006528	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
258594006529	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
258594006530	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
258594006531	7 probable transmembrane helices predicted byTMHMM2.0
258594006532	3 probable transmembrane helices predicted byTMHMM2.0
258594006533	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
258594006534	dimerization interface [polypeptide binding]; other site
258594006535	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
258594006536	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594006537	dimer interface [polypeptide binding]; other site
258594006538	putative CheW interface [polypeptide binding]; other site
258594006539	1 probable transmembrane helix predicted byTMHMM2.0
258594006540	aldolase II superfamily protein; Provisional; Region: PRK07044
258594006541	intersubunit interface [polypeptide binding]; other site
258594006542	active site
258594006543	Zn2+ binding site [ion binding]; other site
258594006544	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
258594006545	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
258594006546	classical (c) SDRs; Region: SDR_c; cd05233
258594006547	NAD(P) binding site [chemical binding]; other site
258594006548	active site
258594006549	1 probable transmembrane helix predicted byTMHMM2.0
258594006550	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594006551	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594006552	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
258594006553	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
258594006554	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594006555	putative active site [active]
258594006556	heme pocket [chemical binding]; other site
258594006557	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594006558	dimer interface [polypeptide binding]; other site
258594006559	phosphorylation site [posttranslational modification]
258594006560	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594006561	ATP binding site [chemical binding]; other site
258594006562	Mg2+ binding site [ion binding]; other site
258594006563	G-X-G motif; other site
258594006564	5 probable transmembrane helices predicted byTMHMM2.0
258594006565	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
258594006566	1 probable transmembrane helix predicted byTMHMM2.0
258594006567	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
258594006568	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
258594006569	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
258594006570	NodB motif; other site
258594006571	active site
258594006572	catalytic site [active]
258594006573	metal binding site [ion binding]; metal-binding site
258594006574	1 probable transmembrane helix predicted byTMHMM2.0
258594006575	1 probable transmembrane helix predicted byTMHMM2.0
258594006576	Predicted integral membrane protein [Function unknown]; Region: COG5436
258594006577	1 probable transmembrane helix predicted byTMHMM2.0
258594006578	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
258594006579	1 probable transmembrane helix predicted byTMHMM2.0
258594006580	Transglycosylase; Region: Transgly; pfam00912
258594006581	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
258594006582	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
258594006583	hypothetical protein; Provisional; Region: PRK05170
258594006584	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
258594006585	8 probable transmembrane helices predicted byTMHMM2.0
258594006586	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
258594006587	MarR family; Region: MarR_2; pfam12802
258594006588	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
258594006589	Cytochrome P450; Region: p450; cl12078
258594006590	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
258594006591	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
258594006592	catalytic loop [active]
258594006593	iron binding site [ion binding]; other site
258594006594	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594006595	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
258594006596	putative ligand binding site [chemical binding]; other site
258594006597	2 probable transmembrane helices predicted byTMHMM2.0
258594006598	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
258594006599	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
258594006600	4 probable transmembrane helices predicted byTMHMM2.0
258594006601	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
258594006602	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594006603	N-terminal plug; other site
258594006604	ligand-binding site [chemical binding]; other site
258594006605	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
258594006606	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
258594006607	Beta-lactamase; Region: Beta-lactamase; pfam00144
258594006608	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
258594006609	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
258594006610	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
258594006611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594006612	putative substrate translocation pore; other site
258594006613	14 probable transmembrane helices predicted byTMHMM2.0
258594006614	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
258594006615	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
258594006616	2 probable transmembrane helices predicted byTMHMM2.0
258594006617	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
258594006618	1 probable transmembrane helix predicted byTMHMM2.0
258594006619	13 probable transmembrane helices predicted byTMHMM2.0
258594006620	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
258594006621	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594006622	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
258594006623	putative active site [active]
258594006624	heme pocket [chemical binding]; other site
258594006625	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594006626	putative active site [active]
258594006627	heme pocket [chemical binding]; other site
258594006628	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
258594006629	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594006630	dimer interface [polypeptide binding]; other site
258594006631	putative CheW interface [polypeptide binding]; other site
258594006632	Phage-related protein [Function unknown]; Region: COG4695
258594006633	Phage portal protein; Region: Phage_portal; pfam04860
258594006634	1 probable transmembrane helix predicted byTMHMM2.0
258594006635	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
258594006636	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
258594006637	Phage capsid family; Region: Phage_capsid; pfam05065
258594006638	Domain of unknown function (DUF2019); Region: DUF2019; pfam09450
258594006639	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
258594006640	Uncharacterized conserved protein [Function unknown]; Region: COG5323
258594006641	Terminase-like family; Region: Terminase_6; pfam03237
258594006642	1 probable transmembrane helix predicted byTMHMM2.0
258594006643	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
258594006644	active site
258594006645	substrate binding sites [chemical binding]; other site
258594006646	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
258594006647	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
258594006648	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
258594006649	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
258594006650	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
258594006651	Phage major tail protein 2; Region: Phage_tail_2; cl11463
258594006652	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
258594006653	phage conserved hypothetical protein; Region: phage_TIGR02216
258594006654	Phage-related minor tail protein [Function unknown]; Region: COG5281
258594006655	TIGR02217 family protein; Region: chp_TIGR02217
258594006656	Uncharacterized conserved protein [Function unknown]; Region: COG1479
258594006657	Protein of unknown function DUF262; Region: DUF262; pfam03235
258594006658	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
258594006659	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
258594006660	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
258594006661	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
258594006662	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
258594006663	putative phage cell wall peptidase, NlpC/P60 family; Region: phage_NlpC_fam; TIGR02219
258594006664	Uncharacterized conserved protein [Function unknown]; Region: COG3791
258594006665	1 probable transmembrane helix predicted byTMHMM2.0
258594006666	Transcriptional regulators [Transcription]; Region: MarR; COG1846
258594006667	MarR family; Region: MarR_2; pfam12802
258594006668	4 probable transmembrane helices predicted byTMHMM2.0
258594006669	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
258594006670	4 probable transmembrane helices predicted byTMHMM2.0
258594006671	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
258594006672	Putative phage tail protein; Region: Phage-tail_3; pfam13550
258594006673	1 probable transmembrane helix predicted byTMHMM2.0
258594006674	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
258594006675	Predicted chitinase [General function prediction only]; Region: COG3179
258594006676	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
258594006677	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594006678	active site
258594006679	phosphorylation site [posttranslational modification]
258594006680	intermolecular recognition site; other site
258594006681	dimerization interface [polypeptide binding]; other site
258594006682	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
258594006683	DNA binding site [nucleotide binding]
258594006684	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594006685	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
258594006686	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594006687	ATP binding site [chemical binding]; other site
258594006688	Mg2+ binding site [ion binding]; other site
258594006689	G-X-G motif; other site
258594006690	2 probable transmembrane helices predicted byTMHMM2.0
258594006691	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
258594006692	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
258594006693	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
258594006694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
258594006695	binding surface
258594006696	TPR motif; other site
258594006697	2 probable transmembrane helices predicted byTMHMM2.0
258594006698	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
258594006699	1 probable transmembrane helix predicted byTMHMM2.0
258594006700	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
258594006701	14 probable transmembrane helices predicted byTMHMM2.0
258594006702	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
258594006703	2 probable transmembrane helices predicted byTMHMM2.0
258594006704	formamidase; Provisional; Region: amiF; PRK13287
258594006705	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
258594006706	multimer interface [polypeptide binding]; other site
258594006707	active site
258594006708	catalytic triad [active]
258594006709	dimer interface [polypeptide binding]; other site
258594006710	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
258594006711	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
258594006712	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594006713	putative substrate translocation pore; other site
258594006714	14 probable transmembrane helices predicted byTMHMM2.0
258594006715	Helix-turn-helix domain; Region: HTH_31; pfam13560
258594006716	salt bridge; other site
258594006717	non-specific DNA binding site [nucleotide binding]; other site
258594006718	sequence-specific DNA binding site [nucleotide binding]; other site
258594006719	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
258594006720	diiron binding motif [ion binding]; other site
258594006721	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
258594006722	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
258594006723	catalytic loop [active]
258594006724	iron binding site [ion binding]; other site
258594006725	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
258594006726	diiron binding motif [ion binding]; other site
258594006727	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
258594006728	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
258594006729	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
258594006730	protein binding site [polypeptide binding]; other site
258594006731	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
258594006732	protein binding site [polypeptide binding]; other site
258594006733	1 probable transmembrane helix predicted byTMHMM2.0
258594006734	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
258594006735	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594006736	active site
258594006737	phosphorylation site [posttranslational modification]
258594006738	intermolecular recognition site; other site
258594006739	dimerization interface [polypeptide binding]; other site
258594006740	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
258594006741	DNA binding site [nucleotide binding]
258594006742	PAS fold; Region: PAS_3; pfam08447
258594006743	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594006744	putative active site [active]
258594006745	heme pocket [chemical binding]; other site
258594006746	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
258594006747	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594006748	dimer interface [polypeptide binding]; other site
258594006749	putative CheW interface [polypeptide binding]; other site
258594006750	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594006751	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
258594006752	dimerization interface [polypeptide binding]; other site
258594006753	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594006754	dimer interface [polypeptide binding]; other site
258594006755	phosphorylation site [posttranslational modification]
258594006756	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594006757	ATP binding site [chemical binding]; other site
258594006758	Mg2+ binding site [ion binding]; other site
258594006759	G-X-G motif; other site
258594006760	2 probable transmembrane helices predicted byTMHMM2.0
258594006761	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
258594006762	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
258594006763	metal binding triad; other site
258594006764	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
258594006765	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
258594006766	metal binding triad; other site
258594006767	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
258594006768	1 probable transmembrane helix predicted byTMHMM2.0
258594006769	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
258594006770	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594006771	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
258594006772	catalytic triad [active]
258594006773	putative active site [active]
258594006774	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
258594006775	Autotransporter beta-domain; Region: Autotransporter; smart00869
258594006776	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
258594006777	Transposase; Region: DEDD_Tnp_IS110; pfam01548
258594006778	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
258594006779	IS element
258594006780	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594006781	PAS fold; Region: PAS_3; pfam08447
258594006782	putative active site [active]
258594006783	heme pocket [chemical binding]; other site
258594006784	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
258594006785	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594006786	dimer interface [polypeptide binding]; other site
258594006787	phosphorylation site [posttranslational modification]
258594006788	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594006789	ATP binding site [chemical binding]; other site
258594006790	Mg2+ binding site [ion binding]; other site
258594006791	G-X-G motif; other site
258594006792	2 probable transmembrane helices predicted byTMHMM2.0
258594006793	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
258594006794	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
258594006795	Cation efflux family; Region: Cation_efflux; cl00316
258594006796	Cation efflux family; Region: Cation_efflux; cl00316
258594006797	6 probable transmembrane helices predicted byTMHMM2.0
258594006798	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
258594006799	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
258594006800	NAD(P) binding site [chemical binding]; other site
258594006801	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
258594006802	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
258594006803	FMN binding site [chemical binding]; other site
258594006804	substrate binding site [chemical binding]; other site
258594006805	putative catalytic residue [active]
258594006806	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
258594006807	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
258594006808	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
258594006809	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
258594006810	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
258594006811	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
258594006812	1 probable transmembrane helix predicted byTMHMM2.0
258594006813	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
258594006814	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594006815	putative substrate translocation pore; other site
258594006816	12 probable transmembrane helices predicted byTMHMM2.0
258594006817	formyl-coenzyme A transferase; Provisional; Region: PRK05398
258594006818	CoA-transferase family III; Region: CoA_transf_3; pfam02515
258594006819	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
258594006820	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
258594006821	DNA-binding site [nucleotide binding]; DNA binding site
258594006822	FCD domain; Region: FCD; pfam07729
258594006823	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
258594006824	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
258594006825	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
258594006826	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
258594006827	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
258594006828	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594006829	FeS/SAM binding site; other site
258594006830	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
258594006831	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
258594006832	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594006833	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594006834	1 probable transmembrane helix predicted byTMHMM2.0
258594006835	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
258594006836	2 probable transmembrane helices predicted byTMHMM2.0
258594006837	Fusaric acid resistance protein family; Region: FUSC; pfam04632
258594006838	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
258594006839	10 probable transmembrane helices predicted byTMHMM2.0
258594006840	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594006841	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594006842	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
258594006843	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
258594006844	substrate binding site [chemical binding]; other site
258594006845	catalytic Zn binding site [ion binding]; other site
258594006846	NAD binding site [chemical binding]; other site
258594006847	structural Zn binding site [ion binding]; other site
258594006848	dimer interface [polypeptide binding]; other site
258594006849	HerA helicase [Replication, recombination, and repair]; Region: COG0433
258594006850	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
258594006851	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
258594006852	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594006853	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594006854	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594006855	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594006856	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594006857	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594006858	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594006859	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
258594006860	11 probable transmembrane helices predicted byTMHMM2.0
258594006861	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
258594006862	nucleophile elbow; other site
258594006863	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
258594006864	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
258594006865	cyclase homology domain; Region: CHD; cd07302
258594006866	nucleotidyl binding site; other site
258594006867	metal binding site [ion binding]; metal-binding site
258594006868	dimer interface [polypeptide binding]; other site
258594006869	1 probable transmembrane helix predicted byTMHMM2.0
258594006870	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594006871	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594006872	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
258594006873	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594006874	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594006875	SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057
258594006876	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594006877	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
258594006878	11 probable transmembrane helices predicted byTMHMM2.0
258594006879	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
258594006880	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
258594006881	FMN binding site [chemical binding]; other site
258594006882	active site
258594006883	catalytic residues [active]
258594006884	substrate binding site [chemical binding]; other site
258594006885	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
258594006886	catalytic motif [active]
258594006887	Catalytic residue [active]
258594006888	1 probable transmembrane helix predicted byTMHMM2.0
258594006889	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
258594006890	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594006891	dimer interface [polypeptide binding]; other site
258594006892	phosphorylation site [posttranslational modification]
258594006893	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594006894	ATP binding site [chemical binding]; other site
258594006895	Mg2+ binding site [ion binding]; other site
258594006896	G-X-G motif; other site
258594006897	5 probable transmembrane helices predicted byTMHMM2.0
258594006898	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
258594006899	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
258594006900	Domain of unknown function DUF59; Region: DUF59; pfam01883
258594006901	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
258594006902	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
258594006903	Walker A motif; other site
258594006904	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
258594006905	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
258594006906	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
258594006907	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
258594006908	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
258594006909	17 probable transmembrane helices predicted byTMHMM2.0
258594006910	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
258594006911	4 probable transmembrane helices predicted byTMHMM2.0
258594006912	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
258594006913	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594006914	FeS/SAM binding site; other site
258594006915	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
258594006916	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
258594006917	phosphoglycolate phosphatase; Provisional; Region: PRK13222
258594006918	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594006919	motif II; other site
258594006920	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
258594006921	tetramer (dimer of dimers) interface [polypeptide binding]; other site
258594006922	active site
258594006923	dimer interface [polypeptide binding]; other site
258594006924	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
258594006925	1 probable transmembrane helix predicted byTMHMM2.0
258594006926	glutathione reductase; Validated; Region: PRK06116
258594006927	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
258594006928	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
258594006929	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
258594006930	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
258594006931	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
258594006932	3 probable transmembrane helices predicted byTMHMM2.0
258594006933	NAD synthetase; Provisional; Region: PRK13981
258594006934	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
258594006935	multimer interface [polypeptide binding]; other site
258594006936	active site
258594006937	catalytic triad [active]
258594006938	protein interface 1 [polypeptide binding]; other site
258594006939	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
258594006940	homodimer interface [polypeptide binding]; other site
258594006941	NAD binding pocket [chemical binding]; other site
258594006942	ATP binding pocket [chemical binding]; other site
258594006943	Mg binding site [ion binding]; other site
258594006944	active-site loop [active]
258594006945	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
258594006946	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594006947	2 probable transmembrane helices predicted byTMHMM2.0
258594006948	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
258594006949	Sulfatase; Region: Sulfatase; cl17466
258594006950	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
258594006951	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
258594006952	oligomeric interface; other site
258594006953	putative active site [active]
258594006954	homodimer interface [polypeptide binding]; other site
258594006955	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
258594006956	Cupin domain; Region: Cupin_2; pfam07883
258594006957	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
258594006958	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
258594006959	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
258594006960	active site
258594006961	HIGH motif; other site
258594006962	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
258594006963	KMSKS motif; other site
258594006964	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
258594006965	1 probable transmembrane helix predicted byTMHMM2.0
258594006966	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
258594006967	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594006968	Coenzyme A binding pocket [chemical binding]; other site
258594006969	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
258594006970	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
258594006971	active site
258594006972	catalytic residues [active]
258594006973	metal binding site [ion binding]; metal-binding site
258594006974	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
258594006975	hypothetical protein; Provisional; Region: PRK12474
258594006976	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
258594006977	PYR/PP interface [polypeptide binding]; other site
258594006978	dimer interface [polypeptide binding]; other site
258594006979	TPP binding site [chemical binding]; other site
258594006980	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
258594006981	TPP-binding site [chemical binding]; other site
258594006982	dimer interface [polypeptide binding]; other site
258594006983	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
258594006984	FAD binding domain; Region: FAD_binding_4; pfam01565
258594006985	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
258594006986	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
258594006987	Cytochrome c; Region: Cytochrom_C; pfam00034
258594006988	Cytochrome c [Energy production and conversion]; Region: COG3258
258594006989	Cytochrome c; Region: Cytochrom_C; pfam00034
258594006990	1 probable transmembrane helix predicted byTMHMM2.0
258594006991	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
258594006992	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
258594006993	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
258594006994	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
258594006995	Walker A/P-loop; other site
258594006996	ATP binding site [chemical binding]; other site
258594006997	Q-loop/lid; other site
258594006998	ABC transporter signature motif; other site
258594006999	Walker B; other site
258594007000	D-loop; other site
258594007001	H-loop/switch region; other site
258594007002	5 probable transmembrane helices predicted byTMHMM2.0
258594007003	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
258594007004	1 probable transmembrane helix predicted byTMHMM2.0
258594007005	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
258594007006	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
258594007007	CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009
258594007008	5 probable transmembrane helices predicted byTMHMM2.0
258594007009	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
258594007010	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
258594007011	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
258594007012	4 probable transmembrane helices predicted byTMHMM2.0
258594007013	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
258594007014	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
258594007015	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
258594007016	ligand binding site [chemical binding]; other site
258594007017	1 probable transmembrane helix predicted byTMHMM2.0
258594007018	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
258594007019	12 probable transmembrane helices predicted byTMHMM2.0
258594007020	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
258594007021	active site residue [active]
258594007022	hypothetical protein; Provisional; Region: PRK08912
258594007023	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
258594007024	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594007025	homodimer interface [polypeptide binding]; other site
258594007026	catalytic residue [active]
258594007027	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
258594007028	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
258594007029	Protein of unknown function (DUF1551); Region: DUF1551; pfam07585
258594007030	1 probable transmembrane helix predicted byTMHMM2.0
258594007031	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
258594007032	B12 binding site [chemical binding]; other site
258594007033	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
258594007034	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594007035	FeS/SAM binding site; other site
258594007036	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
258594007037	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
258594007038	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
258594007039	putative acyl-acceptor binding pocket; other site
258594007040	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
258594007041	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
258594007042	NAD(P) binding site [chemical binding]; other site
258594007043	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
258594007044	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
258594007045	dimer interface [polypeptide binding]; other site
258594007046	active site
258594007047	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
258594007048	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
258594007049	active site
258594007050	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
258594007051	acyl carrier protein; Provisional; Region: PRK06508
258594007052	1 probable transmembrane helix predicted byTMHMM2.0
258594007053	Putative ParB-like nuclease; Region: ParBc_2; cl17538
258594007054	MgtC family; Region: MgtC; pfam02308
258594007055	4 probable transmembrane helices predicted byTMHMM2.0
258594007056	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
258594007057	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594007058	N-terminal plug; other site
258594007059	ligand-binding site [chemical binding]; other site
258594007060	HerA helicase [Replication, recombination, and repair]; Region: COG0433
258594007061	Domain of unknown function DUF87; Region: DUF87; pfam01935
258594007062	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
258594007063	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
258594007064	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594007065	motif II; other site
258594007066	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
258594007067	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
258594007068	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
258594007069	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
258594007070	PYR/PP interface [polypeptide binding]; other site
258594007071	dimer interface [polypeptide binding]; other site
258594007072	TPP binding site [chemical binding]; other site
258594007073	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
258594007074	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
258594007075	TPP-binding site [chemical binding]; other site
258594007076	dimer interface [polypeptide binding]; other site
258594007077	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
258594007078	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
258594007079	putative valine binding site [chemical binding]; other site
258594007080	dimer interface [polypeptide binding]; other site
258594007081	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
258594007082	Protein required for attachment to host cells; Region: Host_attach; pfam10116
258594007083	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
258594007084	EamA-like transporter family; Region: EamA; pfam00892
258594007085	EamA-like transporter family; Region: EamA; pfam00892
258594007086	10 probable transmembrane helices predicted byTMHMM2.0
258594007087	ketol-acid reductoisomerase; Provisional; Region: PRK05479
258594007088	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
258594007089	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
258594007090	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
258594007091	Transcriptional regulators [Transcription]; Region: FadR; COG2186
258594007092	DNA-binding site [nucleotide binding]; DNA binding site
258594007093	FCD domain; Region: FCD; pfam07729
258594007094	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
258594007095	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594007096	putative ligand binding site [chemical binding]; other site
258594007097	1 probable transmembrane helix predicted byTMHMM2.0
258594007098	short chain dehydrogenase; Provisional; Region: PRK06914
258594007099	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
258594007100	NADP binding site [chemical binding]; other site
258594007101	active site
258594007102	steroid binding site; other site
258594007103	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594007104	dimer interface [polypeptide binding]; other site
258594007105	conserved gate region; other site
258594007106	ABC-ATPase subunit interface; other site
258594007107	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
258594007108	6 probable transmembrane helices predicted byTMHMM2.0
258594007109	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594007110	ABC transporter signature motif; other site
258594007111	Walker B; other site
258594007112	D-loop; other site
258594007113	H-loop/switch region; other site
258594007114	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
258594007115	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
258594007116	Walker A/P-loop; other site
258594007117	ATP binding site [chemical binding]; other site
258594007118	Q-loop/lid; other site
258594007119	ABC transporter signature motif; other site
258594007120	Walker B; other site
258594007121	D-loop; other site
258594007122	H-loop/switch region; other site
258594007123	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
258594007124	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594007125	dimer interface [polypeptide binding]; other site
258594007126	conserved gate region; other site
258594007127	ABC-ATPase subunit interface; other site
258594007128	6 probable transmembrane helices predicted byTMHMM2.0
258594007129	NMT1-like family; Region: NMT1_2; pfam13379
258594007130	NMT1/THI5 like; Region: NMT1; pfam09084
258594007131	NUDIX domain; Region: NUDIX; pfam00293
258594007132	nudix motif; other site
258594007133	biotin synthase; Region: bioB; TIGR00433
258594007134	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594007135	FeS/SAM binding site; other site
258594007136	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
258594007137	2-isopropylmalate synthase; Validated; Region: PRK00915
258594007138	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
258594007139	active site
258594007140	catalytic residues [active]
258594007141	metal binding site [ion binding]; metal-binding site
258594007142	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
258594007143	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
258594007144	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
258594007145	1 probable transmembrane helix predicted byTMHMM2.0
258594007146	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
258594007147	4 probable transmembrane helices predicted byTMHMM2.0
258594007148	DctM-like transporters; Region: DctM; pfam06808
258594007149	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
258594007150	13 probable transmembrane helices predicted byTMHMM2.0
258594007151	1 probable transmembrane helix predicted byTMHMM2.0
258594007152	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
258594007153	ornithine decarboxylase; Provisional; Region: PRK13578
258594007154	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
258594007155	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594007156	catalytic residue [active]
258594007157	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
258594007158	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
258594007159	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594007160	Coenzyme A binding pocket [chemical binding]; other site
258594007161	1 probable transmembrane helix predicted byTMHMM2.0
258594007162	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
258594007163	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
258594007164	E3 interaction surface; other site
258594007165	lipoyl attachment site [posttranslational modification]; other site
258594007166	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594007167	1 probable transmembrane helix predicted byTMHMM2.0
258594007168	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
258594007169	11 probable transmembrane helices predicted byTMHMM2.0
258594007170	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
258594007171	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
258594007172	dinuclear metal binding motif [ion binding]; other site
258594007173	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
258594007174	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
258594007175	4Fe-4S binding domain; Region: Fer4_5; pfam12801
258594007176	4Fe-4S binding domain; Region: Fer4_5; pfam12801
258594007177	5 probable transmembrane helices predicted byTMHMM2.0
258594007178	nitrous-oxide reductase; Validated; Region: PRK02888
258594007179	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
258594007180	1 probable transmembrane helix predicted byTMHMM2.0
258594007181	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
258594007182	1 probable transmembrane helix predicted byTMHMM2.0
258594007183	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
258594007184	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
258594007185	Walker A/P-loop; other site
258594007186	ATP binding site [chemical binding]; other site
258594007187	Q-loop/lid; other site
258594007188	ABC transporter signature motif; other site
258594007189	Walker B; other site
258594007190	D-loop; other site
258594007191	H-loop/switch region; other site
258594007192	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
258594007193	6 probable transmembrane helices predicted byTMHMM2.0
258594007194	NosL; Region: NosL; pfam05573
258594007195	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
258594007196	ApbE family; Region: ApbE; pfam02424
258594007197	Predicted integral membrane protein [Function unknown]; Region: COG5615
258594007198	4 probable transmembrane helices predicted byTMHMM2.0
258594007199	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
258594007200	12 probable transmembrane helices predicted byTMHMM2.0
258594007201	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
258594007202	Domain of unknown function (DUF378); Region: DUF378; cl00943
258594007203	2 probable transmembrane helices predicted byTMHMM2.0
258594007204	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594007205	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594007206	NAD(P) binding site [chemical binding]; other site
258594007207	active site
258594007208	response regulator; Provisional; Region: PRK13435
258594007209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
258594007210	active site
258594007211	phosphorylation site [posttranslational modification]
258594007212	intermolecular recognition site; other site
258594007213	dimerization interface [polypeptide binding]; other site
258594007214	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
258594007215	GAF domain; Region: GAF; pfam01590
258594007216	PAS domain S-box; Region: sensory_box; TIGR00229
258594007217	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594007218	putative active site [active]
258594007219	heme pocket [chemical binding]; other site
258594007220	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594007221	putative active site [active]
258594007222	PAS fold; Region: PAS_3; pfam08447
258594007223	heme pocket [chemical binding]; other site
258594007224	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
258594007225	HWE histidine kinase; Region: HWE_HK; smart00911
258594007226	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
258594007227	HWE histidine kinase; Region: HWE_HK; smart00911
258594007228	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594007229	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594007230	flexible hinge region; other site
258594007231	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
258594007232	putative switch regulator; other site
258594007233	non-specific DNA interactions [nucleotide binding]; other site
258594007234	DNA binding site [nucleotide binding]
258594007235	sequence specific DNA binding site [nucleotide binding]; other site
258594007236	putative cAMP binding site [chemical binding]; other site
258594007237	1 probable transmembrane helix predicted byTMHMM2.0
258594007238	Domain of unknown function (DUF892); Region: DUF892; cl17410
258594007239	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
258594007240	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
258594007241	NAD binding site [chemical binding]; other site
258594007242	catalytic Zn binding site [ion binding]; other site
258594007243	structural Zn binding site [ion binding]; other site
258594007244	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
258594007245	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
258594007246	intersubunit interface [polypeptide binding]; other site
258594007247	1 probable transmembrane helix predicted byTMHMM2.0
258594007248	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
258594007249	active site
258594007250	SAM binding site [chemical binding]; other site
258594007251	homodimer interface [polypeptide binding]; other site
258594007252	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
258594007253	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
258594007254	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
258594007255	active site
258594007256	SAM binding site [chemical binding]; other site
258594007257	homodimer interface [polypeptide binding]; other site
258594007258	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
258594007259	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
258594007260	active site
258594007261	putative homodimer interface [polypeptide binding]; other site
258594007262	SAM binding site [chemical binding]; other site
258594007263	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
258594007264	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
258594007265	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
258594007266	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
258594007267	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
258594007268	active site
258594007269	SAM binding site [chemical binding]; other site
258594007270	homodimer interface [polypeptide binding]; other site
258594007271	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
258594007272	active site
258594007273	SAM binding site [chemical binding]; other site
258594007274	homodimer interface [polypeptide binding]; other site
258594007275	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
258594007276	Precorrin-8X methylmutase; Region: CbiC; pfam02570
258594007277	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
258594007278	CitB domain protein; Region: CitB; TIGR02484
258594007279	6 probable transmembrane helices predicted byTMHMM2.0
258594007280	precorrin 3B synthase CobZ; Region: CobZ_N-term; TIGR02485
258594007281	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
258594007282	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
258594007283	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
258594007284	putative dimer interface [polypeptide binding]; other site
258594007285	active site pocket [active]
258594007286	putative cataytic base [active]
258594007287	cobalamin synthase; Reviewed; Region: cobS; PRK00235
258594007288	6 probable transmembrane helices predicted byTMHMM2.0
258594007289	cobyric acid synthase; Provisional; Region: PRK00784
258594007290	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
258594007291	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
258594007292	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
258594007293	catalytic triad [active]
258594007294	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
258594007295	homodimer interface [polypeptide binding]; other site
258594007296	active site
258594007297	SAM binding site [chemical binding]; other site
258594007298	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
258594007299	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
258594007300	catalytic triad [active]
258594007301	Transmembrane secretion effector; Region: MFS_3; pfam05977
258594007302	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594007303	putative substrate translocation pore; other site
258594007304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594007305	11 probable transmembrane helices predicted byTMHMM2.0
258594007306	Isochorismatase family; Region: Isochorismatase; pfam00857
258594007307	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
258594007308	catalytic triad [active]
258594007309	dimer interface [polypeptide binding]; other site
258594007310	conserved cis-peptide bond; other site
258594007311	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
258594007312	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
258594007313	active site
258594007314	Predicted membrane protein [Function unknown]; Region: COG2259
258594007315	4 probable transmembrane helices predicted byTMHMM2.0
258594007316	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
258594007317	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
258594007318	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
258594007319	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
258594007320	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
258594007321	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
258594007322	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
258594007323	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
258594007324	Catalytic domain of Protein Kinases; Region: PKc; cd00180
258594007325	active site
258594007326	ATP binding site [chemical binding]; other site
258594007327	substrate binding site [chemical binding]; other site
258594007328	activation loop (A-loop); other site
258594007329	AAA ATPase domain; Region: AAA_16; pfam13191
258594007330	Predicted ATPase [General function prediction only]; Region: COG3899
258594007331	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
258594007332	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
258594007333	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594007334	dimer interface [polypeptide binding]; other site
258594007335	phosphorylation site [posttranslational modification]
258594007336	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594007337	ATP binding site [chemical binding]; other site
258594007338	Mg2+ binding site [ion binding]; other site
258594007339	G-X-G motif; other site
258594007340	Response regulator receiver domain; Region: Response_reg; pfam00072
258594007341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594007342	active site
258594007343	phosphorylation site [posttranslational modification]
258594007344	intermolecular recognition site; other site
258594007345	dimerization interface [polypeptide binding]; other site
258594007346	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
258594007347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594007348	active site
258594007349	phosphorylation site [posttranslational modification]
258594007350	intermolecular recognition site; other site
258594007351	dimerization interface [polypeptide binding]; other site
258594007352	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
258594007353	DNA binding residues [nucleotide binding]
258594007354	dimerization interface [polypeptide binding]; other site
258594007355	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594007356	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
258594007357	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594007358	PAS domain S-box; Region: sensory_box; TIGR00229
258594007359	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594007360	putative active site [active]
258594007361	heme pocket [chemical binding]; other site
258594007362	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
258594007363	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594007364	Walker A motif; other site
258594007365	ATP binding site [chemical binding]; other site
258594007366	Walker B motif; other site
258594007367	arginine finger; other site
258594007368	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
258594007369	NMT1-like family; Region: NMT1_2; pfam13379
258594007370	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
258594007371	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594007372	dimer interface [polypeptide binding]; other site
258594007373	conserved gate region; other site
258594007374	putative PBP binding loops; other site
258594007375	ABC-ATPase subunit interface; other site
258594007376	6 probable transmembrane helices predicted byTMHMM2.0
258594007377	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
258594007378	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
258594007379	Walker A/P-loop; other site
258594007380	ATP binding site [chemical binding]; other site
258594007381	Q-loop/lid; other site
258594007382	ABC transporter signature motif; other site
258594007383	Walker B; other site
258594007384	D-loop; other site
258594007385	H-loop/switch region; other site
258594007386	cyanate hydratase; Validated; Region: PRK02866
258594007387	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
258594007388	oligomer interface [polypeptide binding]; other site
258594007389	active site
258594007390	Protein of unknown function (DUF2023); Region: DUF2023; pfam09633
258594007391	flavodoxin FldA; Validated; Region: PRK09267
258594007392	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
258594007393	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
258594007394	Walker A/P-loop; other site
258594007395	ATP binding site [chemical binding]; other site
258594007396	Q-loop/lid; other site
258594007397	ABC transporter signature motif; other site
258594007398	Walker B; other site
258594007399	D-loop; other site
258594007400	H-loop/switch region; other site
258594007401	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
258594007402	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
258594007403	dimer interface [polypeptide binding]; other site
258594007404	putative PBP binding regions; other site
258594007405	ABC-ATPase subunit  interface; other site
258594007406	9 probable transmembrane helices predicted byTMHMM2.0
258594007407	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
258594007408	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
258594007409	putative hemin binding site; other site
258594007410	1 probable transmembrane helix predicted byTMHMM2.0
258594007411	Hemin uptake protein hemP; Region: hemP; pfam10636
258594007412	coproporphyrinogen III oxidase; Provisional; Region: PRK09058
258594007413	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594007414	FeS/SAM binding site; other site
258594007415	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
258594007416	NADH(P)-binding; Region: NAD_binding_10; pfam13460
258594007417	NAD(P) binding site [chemical binding]; other site
258594007418	putative active site [active]
258594007419	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
258594007420	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594007421	N-terminal plug; other site
258594007422	ligand-binding site [chemical binding]; other site
258594007423	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
258594007424	putative heme utilization carrier protein HutX; Region: HutX; TIGR04108
258594007425	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
258594007426	4 probable transmembrane helices predicted byTMHMM2.0
258594007427	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
258594007428	TonB system transport protein ExbD, group 1; Region: ExbD_1; TIGR02803
258594007429	1 probable transmembrane helix predicted byTMHMM2.0
258594007430	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
258594007431	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
258594007432	1 probable transmembrane helix predicted byTMHMM2.0
258594007433	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
258594007434	7 probable transmembrane helices predicted byTMHMM2.0
258594007435	3 probable transmembrane helices predicted byTMHMM2.0
258594007436	Predicted periplasmic protein [Function unknown]; Region: COG3904
258594007437	3 probable transmembrane helices predicted byTMHMM2.0
258594007438	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594007439	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594007440	dimer interface [polypeptide binding]; other site
258594007441	phosphorylation site [posttranslational modification]
258594007442	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594007443	ATP binding site [chemical binding]; other site
258594007444	G-X-G motif; other site
258594007445	Response regulator receiver domain; Region: Response_reg; pfam00072
258594007446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594007447	active site
258594007448	phosphorylation site [posttranslational modification]
258594007449	intermolecular recognition site; other site
258594007450	dimerization interface [polypeptide binding]; other site
258594007451	2 probable transmembrane helices predicted byTMHMM2.0
258594007452	Cytochrome c; Region: Cytochrom_C; cl11414
258594007453	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594007454	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594007455	active site
258594007456	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594007457	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594007458	active site
258594007459	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
258594007460	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
258594007461	putative C-terminal domain interface [polypeptide binding]; other site
258594007462	putative GSH binding site (G-site) [chemical binding]; other site
258594007463	putative dimer interface [polypeptide binding]; other site
258594007464	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
258594007465	N-terminal domain interface [polypeptide binding]; other site
258594007466	dimer interface [polypeptide binding]; other site
258594007467	substrate binding pocket (H-site) [chemical binding]; other site
258594007468	Helix-turn-helix domain; Region: HTH_18; pfam12833
258594007469	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
258594007470	acyl-CoA synthetase; Validated; Region: PRK08316
258594007471	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594007472	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
258594007473	acyl-activating enzyme (AAE) consensus motif; other site
258594007474	putative AMP binding site [chemical binding]; other site
258594007475	putative active site [active]
258594007476	putative CoA binding site [chemical binding]; other site
258594007477	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
258594007478	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
258594007479	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
258594007480	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
258594007481	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
258594007482	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
258594007483	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
258594007484	carboxyltransferase (CT) interaction site; other site
258594007485	biotinylation site [posttranslational modification]; other site
258594007486	enoyl-CoA hydratase; Provisional; Region: PRK05995
258594007487	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594007488	substrate binding site [chemical binding]; other site
258594007489	oxyanion hole (OAH) forming residues; other site
258594007490	trimer interface [polypeptide binding]; other site
258594007491	acyl-CoA synthetase; Validated; Region: PRK06188
258594007492	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
258594007493	acyl-activating enzyme (AAE) consensus motif; other site
258594007494	putative AMP binding site [chemical binding]; other site
258594007495	putative active site [active]
258594007496	putative CoA binding site [chemical binding]; other site
258594007497	8 probable transmembrane helices predicted byTMHMM2.0
258594007498	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
258594007499	Beta-lactamase; Region: Beta-lactamase; pfam00144
258594007500	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
258594007501	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
258594007502	dimer interface [polypeptide binding]; other site
258594007503	active site
258594007504	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
258594007505	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
258594007506	active site
258594007507	catalytic tetrad [active]
258594007508	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
258594007509	EamA-like transporter family; Region: EamA; pfam00892
258594007510	10 probable transmembrane helices predicted byTMHMM2.0
258594007511	PAS fold; Region: PAS_7; pfam12860
258594007512	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594007513	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594007514	metal binding site [ion binding]; metal-binding site
258594007515	active site
258594007516	I-site; other site
258594007517	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594007518	3 probable transmembrane helices predicted byTMHMM2.0
258594007519	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
258594007520	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
258594007521	NAD binding site [chemical binding]; other site
258594007522	catalytic residues [active]
258594007523	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
258594007524	8 probable transmembrane helices predicted byTMHMM2.0
258594007525	dihydroxy-acid dehydratase; Validated; Region: PRK06131
258594007526	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
258594007527	1 probable transmembrane helix predicted byTMHMM2.0
258594007528	1 probable transmembrane helix predicted byTMHMM2.0
258594007529	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
258594007530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594007531	NAD(P) binding site [chemical binding]; other site
258594007532	active site
258594007533	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594007534	dimerization interface [polypeptide binding]; other site
258594007535	putative DNA binding site [nucleotide binding]; other site
258594007536	putative Zn2+ binding site [ion binding]; other site
258594007537	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
258594007538	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
258594007539	Autotransporter beta-domain; Region: Autotransporter; pfam03797
258594007540	hypothetical protein; Provisional; Region: PRK10396
258594007541	yecA family protein; Region: ygfB_yecA; TIGR02292
258594007542	SEC-C motif; Region: SEC-C; pfam02810
258594007543	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
258594007544	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
258594007545	ring oligomerisation interface [polypeptide binding]; other site
258594007546	ATP/Mg binding site [chemical binding]; other site
258594007547	stacking interactions; other site
258594007548	hinge regions; other site
258594007549	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
258594007550	oligomerisation interface [polypeptide binding]; other site
258594007551	mobile loop; other site
258594007552	roof hairpin; other site
258594007553	Usg-like family; Region: Usg; pfam06233
258594007554	8 probable transmembrane helices predicted byTMHMM2.0
258594007555	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
258594007556	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
258594007557	Nucleoside recognition; Region: Gate; pfam07670
258594007558	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
258594007559	10 probable transmembrane helices predicted byTMHMM2.0
258594007560	Ribulose bisphosphate carboxylase like proteins (RLPs) similar to R.rubrum RLP; Region: RLP_RrRLP; cd08210
258594007561	dimer interface [polypeptide binding]; other site
258594007562	active site
258594007563	catalytic residue [active]
258594007564	metal binding site [ion binding]; metal-binding site
258594007565	Cupin domain; Region: Cupin_2; pfam07883
258594007566	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
258594007567	classical (c) SDRs; Region: SDR_c; cd05233
258594007568	NAD(P) binding site [chemical binding]; other site
258594007569	active site
258594007570	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
258594007571	Coenzyme A binding pocket [chemical binding]; other site
258594007572	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
258594007573	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
258594007574	active site
258594007575	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
258594007576	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
258594007577	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
258594007578	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
258594007579	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
258594007580	Uncharacterized conserved protein [Function unknown]; Region: COG2308
258594007581	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
258594007582	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
258594007583	putative MPT binding site; other site
258594007584	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
258594007585	active site
258594007586	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
258594007587	substrate binding site [chemical binding]; other site
258594007588	methionine synthase; Provisional; Region: PRK01207
258594007589	THF binding site; other site
258594007590	zinc-binding site [ion binding]; other site
258594007591	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
258594007592	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
258594007593	C-terminal domain interface [polypeptide binding]; other site
258594007594	GSH binding site (G-site) [chemical binding]; other site
258594007595	dimer interface [polypeptide binding]; other site
258594007596	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
258594007597	N-terminal domain interface [polypeptide binding]; other site
258594007598	putative dimer interface [polypeptide binding]; other site
258594007599	active site
258594007600	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
258594007601	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
258594007602	putative catalytic residue [active]
258594007603	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
258594007604	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
258594007605	NAD(P) binding site [chemical binding]; other site
258594007606	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
258594007607	putative active site [active]
258594007608	putative catalytic site [active]
258594007609	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
258594007610	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594007611	NAD(P) binding site [chemical binding]; other site
258594007612	active site
258594007613	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
258594007614	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
258594007615	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594007616	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594007617	ABC transporter ATPase component; Reviewed; Region: PRK11147
258594007618	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
258594007619	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
258594007620	hypothetical protein; Validated; Region: PRK00124
258594007621	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
258594007622	active site 2 [active]
258594007623	active site 1 [active]
258594007624	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594007625	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
258594007626	putative ligand binding site [chemical binding]; other site
258594007627	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
258594007628	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
258594007629	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
258594007630	exopolyphosphatase; Region: exo_poly_only; TIGR03706
258594007631	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
258594007632	LysE type translocator; Region: LysE; cl00565
258594007633	5 probable transmembrane helices predicted byTMHMM2.0
258594007634	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
258594007635	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594007636	S-adenosylmethionine binding site [chemical binding]; other site
258594007637	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594007638	putative transporter; Provisional; Region: PRK10504
258594007639	putative substrate translocation pore; other site
258594007640	12 probable transmembrane helices predicted byTMHMM2.0
258594007641	1 probable transmembrane helix predicted byTMHMM2.0
258594007642	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
258594007643	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
258594007644	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
258594007645	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
258594007646	active site
258594007647	Prostaglandin dehydrogenases; Region: PGDH; cd05288
258594007648	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
258594007649	NAD(P) binding site [chemical binding]; other site
258594007650	substrate binding site [chemical binding]; other site
258594007651	dimer interface [polypeptide binding]; other site
258594007652	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
258594007653	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594007654	GMP synthase; Reviewed; Region: guaA; PRK00074
258594007655	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
258594007656	AMP/PPi binding site [chemical binding]; other site
258594007657	candidate oxyanion hole; other site
258594007658	catalytic triad [active]
258594007659	potential glutamine specificity residues [chemical binding]; other site
258594007660	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
258594007661	ATP Binding subdomain [chemical binding]; other site
258594007662	Ligand Binding sites [chemical binding]; other site
258594007663	Dimerization subdomain; other site
258594007664	integrase; Provisional; Region: PRK09692
258594007665	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
258594007666	active site
258594007667	Int/Topo IB signature motif; other site
258594007668	IS element
258594007669	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
258594007670	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
258594007671	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
258594007672	catalytic residues [active]
258594007673	catalytic nucleophile [active]
258594007674	Recombinase; Region: Recombinase; pfam07508
258594007675	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
258594007676	ParB-like nuclease domain; Region: ParB; smart00470
258594007677	RepB plasmid partitioning protein; Region: RepB; pfam07506
258594007678	ParB-like nuclease domain; Region: ParB; smart00470
258594007679	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
258594007680	RepB plasmid partitioning protein; Region: RepB; pfam07506
258594007681	HipA N-terminal domain; Region: Couple_hipA; cl11853
258594007682	HipA-like N-terminal domain; Region: HipA_N; pfam07805
258594007683	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
258594007684	HipA-like C-terminal domain; Region: HipA_C; pfam07804
258594007685	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
258594007686	ATP-binding site [chemical binding]; other site
258594007687	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
258594007688	putative homodimer interface [polypeptide binding]; other site
258594007689	putative active site [active]
258594007690	catalytic site [active]
258594007691	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
258594007692	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
258594007693	ATP binding site [chemical binding]; other site
258594007694	putative Mg++ binding site [ion binding]; other site
258594007695	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
258594007696	nucleotide binding region [chemical binding]; other site
258594007697	ATP-binding site [chemical binding]; other site
258594007698	Part of AAA domain; Region: AAA_19; pfam13245
258594007699	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
258594007700	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
258594007701	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
258594007702	WYL domain; Region: WYL; pfam13280
258594007703	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
258594007704	ATP binding site [chemical binding]; other site
258594007705	putative Mg++ binding site [ion binding]; other site
258594007706	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
258594007707	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
258594007708	nucleotide binding region [chemical binding]; other site
258594007709	ATP-binding site [chemical binding]; other site
258594007710	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
258594007711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594007712	ATP binding site [chemical binding]; other site
258594007713	Mg2+ binding site [ion binding]; other site
258594007714	G-X-G motif; other site
258594007715	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
258594007716	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
258594007717	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
258594007718	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
258594007719	Protein of unknown function (DUF499); Region: DUF499; pfam04465
258594007720	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594007721	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594007722	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
258594007723	dimerization interface [polypeptide binding]; other site
258594007724	substrate binding pocket [chemical binding]; other site
258594007725	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
258594007726	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
258594007727	1 probable transmembrane helix predicted byTMHMM2.0
258594007728	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
258594007729	VirB7 interaction site; other site
258594007730	conjugal transfer protein TrbF; Provisional; Region: PRK13872
258594007731	1 probable transmembrane helix predicted byTMHMM2.0
258594007732	conjugal transfer protein TrbL; Provisional; Region: PRK13875
258594007733	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
258594007734	7 probable transmembrane helices predicted byTMHMM2.0
258594007735	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
258594007736	1 probable transmembrane helix predicted byTMHMM2.0
258594007737	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
258594007738	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
258594007739	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
258594007740	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594007741	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
258594007742	Walker A motif; other site
258594007743	Walker A/P-loop; other site
258594007744	ATP binding site [chemical binding]; other site
258594007745	ATP binding site [chemical binding]; other site
258594007746	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
258594007747	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
258594007748	1 probable transmembrane helix predicted byTMHMM2.0
258594007749	TrbC/VIRB2 family; Region: TrbC; cl01583
258594007750	3 probable transmembrane helices predicted byTMHMM2.0
258594007751	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
258594007752	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
258594007753	ATP binding site [chemical binding]; other site
258594007754	Walker A motif; other site
258594007755	hexamer interface [polypeptide binding]; other site
258594007756	Walker B motif; other site
258594007757	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
258594007758	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
258594007759	Walker A motif; other site
258594007760	ATP binding site [chemical binding]; other site
258594007761	Walker B motif; other site
258594007762	3 probable transmembrane helices predicted byTMHMM2.0
258594007763	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
258594007764	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
258594007765	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
258594007766	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
258594007767	N-acetyl-D-glucosamine binding site [chemical binding]; other site
258594007768	catalytic residue [active]
258594007769	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
258594007770	ParA-like protein; Provisional; Region: PHA02518
258594007771	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
258594007772	P-loop; other site
258594007773	Magnesium ion binding site [ion binding]; other site
258594007774	Replication initiator protein A; Region: RPA; pfam10134
258594007775	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
258594007776	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
258594007777	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594007778	non-specific DNA binding site [nucleotide binding]; other site
258594007779	salt bridge; other site
258594007780	sequence-specific DNA binding site [nucleotide binding]; other site
258594007781	Uncharacterized conserved protein [Function unknown]; Region: COG5489
258594007782	5 probable transmembrane helices predicted byTMHMM2.0
258594007783	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
258594007784	Toprim domain; Region: Toprim_3; pfam13362
258594007785	active site
258594007786	metal binding site [ion binding]; metal-binding site
258594007787	Methyltransferase domain; Region: Methyltransf_26; pfam13659
258594007788	DEAD-like helicases superfamily; Region: DEXDc; smart00487
258594007789	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
258594007790	ATP binding site [chemical binding]; other site
258594007791	putative Mg++ binding site [ion binding]; other site
258594007792	Helicase_C-like; Region: Helicase_C_4; pfam13871
258594007793	ParB-like nuclease domain; Region: ParBc; pfam02195
258594007794	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
258594007795	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
258594007796	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594007797	putative DNA binding site [nucleotide binding]; other site
258594007798	putative Zn2+ binding site [ion binding]; other site
258594007799	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
258594007800	ArsC family; Region: ArsC; pfam03960
258594007801	catalytic residues [active]
258594007802	arsenical pump membrane protein; Provisional; Region: PRK15445
258594007803	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
258594007804	transmembrane helices; other site
258594007805	11 probable transmembrane helices predicted byTMHMM2.0
258594007806	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
258594007807	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
258594007808	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
258594007809	AAA domain; Region: AAA_22; pfam13401
258594007810	Walker A/P-loop; other site
258594007811	ATP binding site [chemical binding]; other site
258594007812	Family description; Region: UvrD_C_2; pfam13538
258594007813	GMP synthase C terminal domain; Region: GMP_synt_C; pfam00958
258594007814	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
258594007815	12 probable transmembrane helices predicted byTMHMM2.0
258594007816	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
258594007817	oligomeric interface; other site
258594007818	putative active site [active]
258594007819	homodimer interface [polypeptide binding]; other site
258594007820	Predicted transcriptional regulator [Transcription]; Region: COG2378
258594007821	HTH domain; Region: HTH_11; pfam08279
258594007822	WYL domain; Region: WYL; pfam13280
258594007823	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
258594007824	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
258594007825	putative C-terminal domain interface [polypeptide binding]; other site
258594007826	putative GSH binding site (G-site) [chemical binding]; other site
258594007827	putative dimer interface [polypeptide binding]; other site
258594007828	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
258594007829	dimer interface [polypeptide binding]; other site
258594007830	N-terminal domain interface [polypeptide binding]; other site
258594007831	putative substrate binding pocket (H-site) [chemical binding]; other site
258594007832	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
258594007833	SnoaL-like domain; Region: SnoaL_2; pfam12680
258594007834	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
258594007835	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
258594007836	pyruvate kinase; Validated; Region: PRK08187
258594007837	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
258594007838	active site
258594007839	domain interfaces; other site
258594007840	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
258594007841	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
258594007842	ArsC family; Region: ArsC; pfam03960
258594007843	putative catalytic residues [active]
258594007844	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594007845	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594007846	Walker A/P-loop; other site
258594007847	ATP binding site [chemical binding]; other site
258594007848	Q-loop/lid; other site
258594007849	ABC transporter signature motif; other site
258594007850	Walker B; other site
258594007851	D-loop; other site
258594007852	H-loop/switch region; other site
258594007853	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594007854	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594007855	Walker A/P-loop; other site
258594007856	ATP binding site [chemical binding]; other site
258594007857	Q-loop/lid; other site
258594007858	ABC transporter signature motif; other site
258594007859	Walker B; other site
258594007860	D-loop; other site
258594007861	H-loop/switch region; other site
258594007862	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594007863	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594007864	TM-ABC transporter signature motif; other site
258594007865	8 probable transmembrane helices predicted byTMHMM2.0
258594007866	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594007867	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594007868	TM-ABC transporter signature motif; other site
258594007869	8 probable transmembrane helices predicted byTMHMM2.0
258594007870	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
258594007871	3 probable transmembrane helices predicted byTMHMM2.0
258594007872	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
258594007873	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
258594007874	8 probable transmembrane helices predicted byTMHMM2.0
258594007875	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
258594007876	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594007877	sequence-specific DNA binding site [nucleotide binding]; other site
258594007878	salt bridge; other site
258594007879	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
258594007880	multidrug efflux system protein; Provisional; Region: PRK11431
258594007881	4 probable transmembrane helices predicted byTMHMM2.0
258594007882	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
258594007883	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
258594007884	G1 box; other site
258594007885	putative GEF interaction site [polypeptide binding]; other site
258594007886	GTP/Mg2+ binding site [chemical binding]; other site
258594007887	Switch I region; other site
258594007888	G2 box; other site
258594007889	G3 box; other site
258594007890	Switch II region; other site
258594007891	G4 box; other site
258594007892	G5 box; other site
258594007893	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
258594007894	Restriction endonuclease; Region: Mrr_cat; pfam04471
258594007895	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
258594007896	hydrophobic ligand binding site; other site
258594007897	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594007898	TPR motif; other site
258594007899	binding surface
258594007900	Tetratricopeptide repeat; Region: TPR_9; pfam13371
258594007901	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
258594007902	FecR protein; Region: FecR; pfam04773
258594007903	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
258594007904	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
258594007905	cyclase homology domain; Region: CHD; cd07302
258594007906	nucleotidyl binding site; other site
258594007907	metal binding site [ion binding]; metal-binding site
258594007908	dimer interface [polypeptide binding]; other site
258594007909	2 probable transmembrane helices predicted byTMHMM2.0
258594007910	CHASE3 domain; Region: CHASE3; pfam05227
258594007911	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
258594007912	dimer interface [polypeptide binding]; other site
258594007913	phosphorylation site [posttranslational modification]
258594007914	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594007915	ATP binding site [chemical binding]; other site
258594007916	Mg2+ binding site [ion binding]; other site
258594007917	G-X-G motif; other site
258594007918	2 probable transmembrane helices predicted byTMHMM2.0
258594007919	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594007920	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594007921	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
258594007922	1 probable transmembrane helix predicted byTMHMM2.0
258594007923	flagellin; Provisional; Region: PRK14708
258594007924	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
258594007925	Domain of Unknown Function (DUF1522); Region: DUF1522; pfam07482
258594007926	Domain of Unknown Function (DUF1522); Region: DUF1522; pfam07482
258594007927	Flagellar protein FlbT; Region: FlbT; cl11455
258594007928	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
258594007929	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
258594007930	DNA binding residues [nucleotide binding]
258594007931	dimerization interface [polypeptide binding]; other site
258594007932	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
258594007933	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
258594007934	DNA binding residues [nucleotide binding]
258594007935	dimerization interface [polypeptide binding]; other site
258594007936	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
258594007937	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
258594007938	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594007939	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
258594007940	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594007941	acyl-activating enzyme (AAE) consensus motif; other site
258594007942	AMP binding site [chemical binding]; other site
258594007943	active site
258594007944	CoA binding site [chemical binding]; other site
258594007945	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
258594007946	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
258594007947	NAD binding site [chemical binding]; other site
258594007948	homodimer interface [polypeptide binding]; other site
258594007949	homotetramer interface [polypeptide binding]; other site
258594007950	active site
258594007951	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
258594007952	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
258594007953	dimer interface [polypeptide binding]; other site
258594007954	active site
258594007955	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594007956	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594007957	active site
258594007958	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
258594007959	4 probable transmembrane helices predicted byTMHMM2.0
258594007960	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
258594007961	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594007962	N-terminal plug; other site
258594007963	ligand-binding site [chemical binding]; other site
258594007964	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
258594007965	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
258594007966	putative ligand binding residues [chemical binding]; other site
258594007967	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
258594007968	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
258594007969	dimer interface [polypeptide binding]; other site
258594007970	putative PBP binding regions; other site
258594007971	ABC-ATPase subunit  interface; other site
258594007972	7 probable transmembrane helices predicted byTMHMM2.0
258594007973	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
258594007974	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594007975	Walker A/P-loop; other site
258594007976	ATP binding site [chemical binding]; other site
258594007977	Q-loop/lid; other site
258594007978	ABC transporter signature motif; other site
258594007979	Walker B; other site
258594007980	D-loop; other site
258594007981	H-loop/switch region; other site
258594007982	Cytochrome C' Region: Cytochrom_C_2; pfam01322
258594007983	1 probable transmembrane helix predicted byTMHMM2.0
258594007984	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
258594007985	5 probable transmembrane helices predicted byTMHMM2.0
258594007986	enoyl-CoA hydratase; Validated; Region: PRK08139
258594007987	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594007988	substrate binding site [chemical binding]; other site
258594007989	oxyanion hole (OAH) forming residues; other site
258594007990	trimer interface [polypeptide binding]; other site
258594007991	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
258594007992	Coenzyme A transferase; Region: CoA_trans; cl17247
258594007993	Coenzyme A transferase; Region: CoA_trans; smart00882
258594007994	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
258594007995	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
258594007996	10 probable transmembrane helices predicted byTMHMM2.0
258594007997	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
258594007998	4 probable transmembrane helices predicted byTMHMM2.0
258594007999	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
258594008000	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594008001	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
258594008002	dimerization interface [polypeptide binding]; other site
258594008003	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
258594008004	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
258594008005	inhibitor-cofactor binding pocket; inhibition site
258594008006	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594008007	catalytic residue [active]
258594008008	succinic semialdehyde dehydrogenase; Region: PLN02278
258594008009	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
258594008010	tetramerization interface [polypeptide binding]; other site
258594008011	NAD(P) binding site [chemical binding]; other site
258594008012	catalytic residues [active]
258594008013	acetylornithine deacetylase; Provisional; Region: PRK06837
258594008014	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
258594008015	metal binding site [ion binding]; metal-binding site
258594008016	dimer interface [polypeptide binding]; other site
258594008017	hypothetical protein; Provisional; Region: PRK12474
258594008018	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
258594008019	PYR/PP interface [polypeptide binding]; other site
258594008020	dimer interface [polypeptide binding]; other site
258594008021	TPP binding site [chemical binding]; other site
258594008022	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
258594008023	TPP-binding site [chemical binding]; other site
258594008024	dimer interface [polypeptide binding]; other site
258594008025	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
258594008026	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
258594008027	1 probable transmembrane helix predicted byTMHMM2.0
258594008028	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
258594008029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594008030	dimer interface [polypeptide binding]; other site
258594008031	conserved gate region; other site
258594008032	putative PBP binding loops; other site
258594008033	ABC-ATPase subunit interface; other site
258594008034	6 probable transmembrane helices predicted byTMHMM2.0
258594008035	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
258594008036	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594008037	dimer interface [polypeptide binding]; other site
258594008038	conserved gate region; other site
258594008039	putative PBP binding loops; other site
258594008040	ABC-ATPase subunit interface; other site
258594008041	5 probable transmembrane helices predicted byTMHMM2.0
258594008042	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
258594008043	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594008044	Walker A/P-loop; other site
258594008045	ATP binding site [chemical binding]; other site
258594008046	Q-loop/lid; other site
258594008047	ABC transporter signature motif; other site
258594008048	Walker B; other site
258594008049	D-loop; other site
258594008050	H-loop/switch region; other site
258594008051	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
258594008052	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594008053	Walker A/P-loop; other site
258594008054	ATP binding site [chemical binding]; other site
258594008055	Q-loop/lid; other site
258594008056	ABC transporter signature motif; other site
258594008057	Walker B; other site
258594008058	D-loop; other site
258594008059	H-loop/switch region; other site
258594008060	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
258594008061	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
258594008062	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
258594008063	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
258594008064	Staphylococcal nuclease homologues; Region: SNc; smart00318
258594008065	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
258594008066	Catalytic site; other site
258594008067	1 probable transmembrane helix predicted byTMHMM2.0
258594008068	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
258594008069	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
258594008070	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594008071	motif II; other site
258594008072	1 probable transmembrane helix predicted byTMHMM2.0
258594008073	Heavy-metal-associated domain; Region: HMA; pfam00403
258594008074	2 probable transmembrane helices predicted byTMHMM2.0
258594008075	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
258594008076	metal binding site 2 [ion binding]; metal-binding site
258594008077	putative DNA binding helix; other site
258594008078	metal binding site 1 [ion binding]; metal-binding site
258594008079	dimer interface [polypeptide binding]; other site
258594008080	structural Zn2+ binding site [ion binding]; other site
258594008081	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
258594008082	Dehydratase family; Region: ILVD_EDD; pfam00920
258594008083	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594008084	metabolite-proton symporter; Region: 2A0106; TIGR00883
258594008085	putative substrate translocation pore; other site
258594008086	12 probable transmembrane helices predicted byTMHMM2.0
258594008087	Transcriptional regulators [Transcription]; Region: FadR; COG2186
258594008088	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
258594008089	DNA-binding site [nucleotide binding]; DNA binding site
258594008090	FCD domain; Region: FCD; pfam07729
258594008091	Cupin domain; Region: Cupin_2; cl17218
258594008092	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
258594008093	Nitrogenase_vnfN_like: VnfN subunit of the VnfEN complex-like.  This group in addition to VnfN contains a subset of the beta subunit of the nitrogenase MoFe protein and NifN-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfN_like; cd01971
258594008094	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
258594008095	Nitrogenase_VnfE_like: VnfE subunit of the VnfEN complex_like. This group in addition to VnfE contains a subset of the alpha subunit of the nitrogenase MoFe protein and NifE-like proteins.  The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfE_like; cd01972
258594008096	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
258594008097	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
258594008098	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
258594008099	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594008100	catalytic residue [active]
258594008101	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
258594008102	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594008103	catalytic residue [active]
258594008104	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
258594008105	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594008106	putative DNA binding site [nucleotide binding]; other site
258594008107	putative Zn2+ binding site [ion binding]; other site
258594008108	AsnC family; Region: AsnC_trans_reg; pfam01037
258594008109	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
258594008110	Cupin domain; Region: Cupin_2; pfam07883
258594008111	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
258594008112	nitrogenase iron protein; Region: nifH; TIGR01287
258594008113	Nucleotide-binding sites [chemical binding]; other site
258594008114	Walker A motif; other site
258594008115	Switch I region of nucleotide binding site; other site
258594008116	Fe4S4 binding sites [ion binding]; other site
258594008117	Switch II region of nucleotide binding site; other site
258594008118	Radical SAM superfamily; Region: Radical_SAM; pfam04055
258594008119	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594008120	FeS/SAM binding site; other site
258594008121	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
258594008122	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
258594008123	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
258594008124	dimer interface [polypeptide binding]; other site
258594008125	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594008126	catalytic residue [active]
258594008127	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
258594008128	FOG: CBS domain [General function prediction only]; Region: COG0517
258594008129	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
258594008130	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
258594008131	homodimer interface [polypeptide binding]; other site
258594008132	substrate-cofactor binding pocket; other site
258594008133	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594008134	catalytic residue [active]
258594008135	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
258594008136	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
258594008137	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
258594008138	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
258594008139	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
258594008140	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
258594008141	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
258594008142	Walker A/P-loop; other site
258594008143	ATP binding site [chemical binding]; other site
258594008144	Q-loop/lid; other site
258594008145	ABC transporter signature motif; other site
258594008146	Walker B; other site
258594008147	D-loop; other site
258594008148	H-loop/switch region; other site
258594008149	NIL domain; Region: NIL; pfam09383
258594008150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594008151	dimer interface [polypeptide binding]; other site
258594008152	conserved gate region; other site
258594008153	ABC-ATPase subunit interface; other site
258594008154	5 probable transmembrane helices predicted byTMHMM2.0
258594008155	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
258594008156	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
258594008157	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594008158	catalytic residue [active]
258594008159	Nitrogenase_VnfE_like: VnfE subunit of the VnfEN complex_like. This group in addition to VnfE contains a subset of the alpha subunit of the nitrogenase MoFe protein and NifE-like proteins.  The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfE_like; cd01972
258594008160	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
258594008161	Nitrogenase_vnfN_like: VnfN subunit of the VnfEN complex-like.  This group in addition to VnfN contains a subset of the beta subunit of the nitrogenase MoFe protein and NifN-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfN_like; cd01971
258594008162	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
258594008163	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
258594008164	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
258594008165	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594008166	catalytic residue [active]
258594008167	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
258594008168	dimerization interface [polypeptide binding]; other site
258594008169	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594008170	dimer interface [polypeptide binding]; other site
258594008171	phosphorylation site [posttranslational modification]
258594008172	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594008173	ATP binding site [chemical binding]; other site
258594008174	Mg2+ binding site [ion binding]; other site
258594008175	G-X-G motif; other site
258594008176	2 probable transmembrane helices predicted byTMHMM2.0
258594008177	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
258594008178	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
258594008179	DNA binding site [nucleotide binding]
258594008180	Response regulator receiver domain; Region: Response_reg; pfam00072
258594008181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594008182	active site
258594008183	phosphorylation site [posttranslational modification]
258594008184	intermolecular recognition site; other site
258594008185	dimerization interface [polypeptide binding]; other site
258594008186	1 probable transmembrane helix predicted byTMHMM2.0
258594008187	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
258594008188	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594008189	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594008190	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
258594008191	Protein export membrane protein; Region: SecD_SecF; cl14618
258594008192	12 probable transmembrane helices predicted byTMHMM2.0
258594008193	Outer membrane efflux protein; Region: OEP; pfam02321
258594008194	Outer membrane efflux protein; Region: OEP; pfam02321
258594008195	2 probable transmembrane helices predicted byTMHMM2.0
258594008196	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
258594008197	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
258594008198	9 probable transmembrane helices predicted byTMHMM2.0
258594008199	conserved hypothetical protein
258594008200	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
258594008201	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
258594008202	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594008203	N-terminal plug; other site
258594008204	ligand-binding site [chemical binding]; other site
258594008205	putative acetyltransferase YhhY; Provisional; Region: PRK10140
258594008206	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594008207	Coenzyme A binding pocket [chemical binding]; other site
258594008208	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
258594008209	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
258594008210	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
258594008211	FecR protein; Region: FecR; pfam04773
258594008212	1 probable transmembrane helix predicted byTMHMM2.0
258594008213	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
258594008214	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
258594008215	Walker A/P-loop; other site
258594008216	ATP binding site [chemical binding]; other site
258594008217	Q-loop/lid; other site
258594008218	ABC transporter signature motif; other site
258594008219	Walker B; other site
258594008220	D-loop; other site
258594008221	H-loop/switch region; other site
258594008222	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
258594008223	ABC-ATPase subunit  interface; other site
258594008224	putative PBP binding regions; other site
258594008225	8 probable transmembrane helices predicted byTMHMM2.0
258594008226	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
258594008227	ABC-ATPase subunit  interface; other site
258594008228	dimer interface [polypeptide binding]; other site
258594008229	putative PBP binding regions; other site
258594008230	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
258594008231	9 probable transmembrane helices predicted byTMHMM2.0
258594008232	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
258594008233	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
258594008234	putative ligand binding residues [chemical binding]; other site
258594008235	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
258594008236	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
258594008237	acyl-CoA synthetase; Validated; Region: PRK08308
258594008238	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594008239	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594008240	active site
258594008241	CoA binding site [chemical binding]; other site
258594008242	AMP binding site [chemical binding]; other site
258594008243	IucA / IucC family; Region: IucA_IucC; pfam04183
258594008244	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
258594008245	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
258594008246	IucA / IucC family; Region: IucA_IucC; pfam04183
258594008247	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
258594008248	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
258594008249	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594008250	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
258594008251	DNA binding residues [nucleotide binding]
258594008252	pseudo gene with part of ABC ATPase and transcriptional regulator
258594008253	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
258594008254	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
258594008255	oxalacetate binding site [chemical binding]; other site
258594008256	citrylCoA binding site [chemical binding]; other site
258594008257	coenzyme A binding site [chemical binding]; other site
258594008258	catalytic triad [active]
258594008259	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
258594008260	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
258594008261	tetramer interface [polypeptide binding]; other site
258594008262	active site
258594008263	Mg2+/Mn2+ binding site [ion binding]; other site
258594008264	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
258594008265	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
258594008266	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
258594008267	THF binding site; other site
258594008268	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
258594008269	substrate binding site [chemical binding]; other site
258594008270	THF binding site; other site
258594008271	zinc-binding site [ion binding]; other site
258594008272	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
258594008273	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594008274	N-terminal plug; other site
258594008275	ligand-binding site [chemical binding]; other site
258594008276	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
258594008277	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
258594008278	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
258594008279	1 probable transmembrane helix predicted byTMHMM2.0
258594008280	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
258594008281	3 probable transmembrane helices predicted byTMHMM2.0
258594008282	Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919
258594008283	1 probable transmembrane helix predicted byTMHMM2.0
258594008284	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
258594008285	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
258594008286	FAD binding pocket [chemical binding]; other site
258594008287	phosphate binding motif [ion binding]; other site
258594008288	NAD binding pocket [chemical binding]; other site
258594008289	Helix-turn-helix domain; Region: HTH_18; pfam12833
258594008290	Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357
258594008291	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
258594008292	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594008293	Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357
258594008294	ligand binding site [chemical binding]; other site
258594008295	regulator interaction site; other site
258594008296	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
258594008297	ANTAR domain; Region: ANTAR; cl04297
258594008298	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594008299	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356
258594008300	putative ligand binding site [chemical binding]; other site
258594008301	1 probable transmembrane helix predicted byTMHMM2.0
258594008302	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594008303	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594008304	TM-ABC transporter signature motif; other site
258594008305	8 probable transmembrane helices predicted byTMHMM2.0
258594008306	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594008307	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594008308	TM-ABC transporter signature motif; other site
258594008309	10 probable transmembrane helices predicted byTMHMM2.0
258594008310	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
258594008311	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594008312	Walker A/P-loop; other site
258594008313	ATP binding site [chemical binding]; other site
258594008314	Q-loop/lid; other site
258594008315	ABC transporter signature motif; other site
258594008316	Walker B; other site
258594008317	D-loop; other site
258594008318	H-loop/switch region; other site
258594008319	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594008320	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594008321	Walker A/P-loop; other site
258594008322	ATP binding site [chemical binding]; other site
258594008323	Q-loop/lid; other site
258594008324	ABC transporter signature motif; other site
258594008325	Walker B; other site
258594008326	D-loop; other site
258594008327	H-loop/switch region; other site
258594008328	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
258594008329	Predicted amidohydrolase [General function prediction only]; Region: COG0388
258594008330	First nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R1; cd07578
258594008331	putative active site [active]
258594008332	catalytic triad [active]
258594008333	putative dimer interface [polypeptide binding]; other site
258594008334	Second nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R2; cd07579
258594008335	Predicted amidohydrolase [General function prediction only]; Region: COG0388
258594008336	putative active site [active]
258594008337	catalytic triad [active]
258594008338	putative dimer interface [polypeptide binding]; other site
258594008339	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
258594008340	classical (c) SDRs; Region: SDR_c; cd05233
258594008341	NAD(P) binding site [chemical binding]; other site
258594008342	active site
258594008343	pseudogene of ABC transporter, ATPase subunit
258594008344	Porin subfamily; Region: Porin_2; pfam02530
258594008345	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
258594008346	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
258594008347	N-acetyl-D-glucosamine binding site [chemical binding]; other site
258594008348	catalytic residue [active]
258594008349	NADH dehydrogenase; Validated; Region: PRK08183
258594008350	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
258594008351	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
258594008352	conserved cys residue [active]
258594008353	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
258594008354	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
258594008355	conserved cys residue [active]
258594008356	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594008357	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
258594008358	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
258594008359	substrate binding pocket [chemical binding]; other site
258594008360	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
258594008361	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923
258594008362	1 probable transmembrane helix predicted byTMHMM2.0
258594008363	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
258594008364	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
258594008365	2 probable transmembrane helices predicted byTMHMM2.0
258594008366	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
258594008367	12 probable transmembrane helices predicted byTMHMM2.0
258594008368	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
258594008369	Response regulator receiver domain; Region: Response_reg; pfam00072
258594008370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594008371	active site
258594008372	phosphorylation site [posttranslational modification]
258594008373	intermolecular recognition site; other site
258594008374	dimerization interface [polypeptide binding]; other site
258594008375	Histidine kinase; Region: HisKA_2; pfam07568
258594008376	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
258594008377	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594008378	ATP binding site [chemical binding]; other site
258594008379	Mg2+ binding site [ion binding]; other site
258594008380	G-X-G motif; other site
258594008381	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594008382	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594008383	active site
258594008384	phosphorylation site [posttranslational modification]
258594008385	intermolecular recognition site; other site
258594008386	dimerization interface [polypeptide binding]; other site
258594008387	CHASE3 domain; Region: CHASE3; pfam05227
258594008388	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594008389	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
258594008390	dimer interface [polypeptide binding]; other site
258594008391	phosphorylation site [posttranslational modification]
258594008392	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594008393	ATP binding site [chemical binding]; other site
258594008394	Mg2+ binding site [ion binding]; other site
258594008395	G-X-G motif; other site
258594008396	2 probable transmembrane helices predicted byTMHMM2.0
258594008397	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
258594008398	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
258594008399	ATP-grasp domain; Region: ATP-grasp_4; cl17255
258594008400	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
258594008401	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
258594008402	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
258594008403	carboxyltransferase (CT) interaction site; other site
258594008404	biotinylation site [posttranslational modification]; other site
258594008405	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
258594008406	Dehydroquinase class II; Region: DHquinase_II; pfam01220
258594008407	trimer interface [polypeptide binding]; other site
258594008408	active site
258594008409	dimer interface [polypeptide binding]; other site
258594008410	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
258594008411	Cation efflux family; Region: Cation_efflux; cl00316
258594008412	6 probable transmembrane helices predicted byTMHMM2.0
258594008413	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594008414	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594008415	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
258594008416	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
258594008417	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
258594008418	catalytic residues [active]
258594008419	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
258594008420	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
258594008421	dimer interface [polypeptide binding]; other site
258594008422	decamer (pentamer of dimers) interface [polypeptide binding]; other site
258594008423	catalytic triad [active]
258594008424	BA14K-like protein; Region: BA14K; pfam07886
258594008425	2 probable transmembrane helices predicted byTMHMM2.0
258594008426	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
258594008427	Peptidase family M48; Region: Peptidase_M48; cl12018
258594008428	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
258594008429	binding surface
258594008430	TPR motif; other site
258594008431	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594008432	binding surface
258594008433	TPR motif; other site
258594008434	1 probable transmembrane helix predicted byTMHMM2.0
258594008435	aspartate aminotransferase; Provisional; Region: PRK05764
258594008436	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
258594008437	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594008438	homodimer interface [polypeptide binding]; other site
258594008439	catalytic residue [active]
258594008440	BioY family; Region: BioY; pfam02632
258594008441	5 probable transmembrane helices predicted byTMHMM2.0
258594008442	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
258594008443	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
258594008444	8 probable transmembrane helices predicted byTMHMM2.0
258594008445	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
258594008446	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
258594008447	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
258594008448	AMIN domain; Region: AMIN; pfam11741
258594008449	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
258594008450	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
258594008451	active site
258594008452	metal binding site [ion binding]; metal-binding site
258594008453	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
258594008454	Transglycosylase; Region: Transgly; pfam00912
258594008455	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
258594008456	1 probable transmembrane helix predicted byTMHMM2.0
258594008457	peptide chain release factor 2; Provisional; Region: PRK07342
258594008458	This domain is found in peptide chain release factors; Region: PCRF; smart00937
258594008459	RF-1 domain; Region: RF-1; pfam00472
258594008460	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
258594008461	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
258594008462	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
258594008463	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
258594008464	Peptidase family M23; Region: Peptidase_M23; pfam01551
258594008465	1 probable transmembrane helix predicted byTMHMM2.0
258594008466	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
258594008467	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
258594008468	catalytic triad [active]
258594008469	Protein of unknown function; Region: DUF3971; pfam13116
258594008470	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
258594008471	1 probable transmembrane helix predicted byTMHMM2.0
258594008472	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
258594008473	4 probable transmembrane helices predicted byTMHMM2.0
258594008474	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594008475	Major Facilitator Superfamily; Region: MFS_1; pfam07690
258594008476	putative substrate translocation pore; other site
258594008477	12 probable transmembrane helices predicted byTMHMM2.0
258594008478	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
258594008479	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
258594008480	active site
258594008481	HIGH motif; other site
258594008482	dimer interface [polypeptide binding]; other site
258594008483	KMSKS motif; other site
258594008484	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
258594008485	RNA binding surface [nucleotide binding]; other site
258594008486	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
258594008487	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
258594008488	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
258594008489	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
258594008490	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594008491	catalytic residue [active]
258594008492	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
258594008493	putative ABC transporter; Region: ycf24; CHL00085
258594008494	FeS assembly ATPase SufC; Region: sufC; TIGR01978
258594008495	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
258594008496	Walker A/P-loop; other site
258594008497	ATP binding site [chemical binding]; other site
258594008498	Q-loop/lid; other site
258594008499	ABC transporter signature motif; other site
258594008500	Walker B; other site
258594008501	D-loop; other site
258594008502	H-loop/switch region; other site
258594008503	FeS assembly protein SufD; Region: sufD; TIGR01981
258594008504	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
258594008505	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
258594008506	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
258594008507	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594008508	catalytic residue [active]
258594008509	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
258594008510	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
258594008511	putative metal binding site [ion binding]; other site
258594008512	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
258594008513	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
258594008514	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
258594008515	homotrimer interaction site [polypeptide binding]; other site
258594008516	putative active site [active]
258594008517	1 probable transmembrane helix predicted byTMHMM2.0
258594008518	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594008519	TPR repeat; Region: TPR_11; pfam13414
258594008520	binding surface
258594008521	TPR motif; other site
258594008522	TPR repeat; Region: TPR_11; pfam13414
258594008523	TPR repeat; Region: TPR_11; pfam13414
258594008524	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594008525	binding surface
258594008526	TPR motif; other site
258594008527	TPR repeat; Region: TPR_11; pfam13414
258594008528	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594008529	TPR repeat; Region: TPR_11; pfam13414
258594008530	binding surface
258594008531	TPR motif; other site
258594008532	TPR repeat; Region: TPR_11; pfam13414
258594008533	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594008534	binding surface
258594008535	TPR motif; other site
258594008536	TPR repeat; Region: TPR_11; pfam13414
258594008537	TfoX N-terminal domain; Region: TfoX_N; pfam04993
258594008538	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594008539	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594008540	metal binding site [ion binding]; metal-binding site
258594008541	active site
258594008542	I-site; other site
258594008543	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
258594008544	DEAD-like helicases superfamily; Region: DEXDc; smart00487
258594008545	ATP binding site [chemical binding]; other site
258594008546	Mg++ binding site [ion binding]; other site
258594008547	motif III; other site
258594008548	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
258594008549	nucleotide binding region [chemical binding]; other site
258594008550	ATP-binding site [chemical binding]; other site
258594008551	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594008552	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
258594008553	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594008554	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
258594008555	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594008556	dimer interface [polypeptide binding]; other site
258594008557	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
258594008558	putative CheW interface [polypeptide binding]; other site
258594008559	2 probable transmembrane helices predicted byTMHMM2.0
258594008560	Caspase domain; Region: Peptidase_C14; pfam00656
258594008561	1 probable transmembrane helix predicted byTMHMM2.0
258594008562	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594008563	salt bridge; other site
258594008564	non-specific DNA binding site [nucleotide binding]; other site
258594008565	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
258594008566	sequence-specific DNA binding site [nucleotide binding]; other site
258594008567	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
258594008568	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
258594008569	putative NAD(P) binding site [chemical binding]; other site
258594008570	2 probable transmembrane helices predicted byTMHMM2.0
258594008571	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
258594008572	amphipathic channel; other site
258594008573	Asn-Pro-Ala signature motifs; other site
258594008574	6 probable transmembrane helices predicted byTMHMM2.0
258594008575	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
258594008576	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594008577	Mg2+ binding site [ion binding]; other site
258594008578	G-X-G motif; other site
258594008579	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
258594008580	anchoring element; other site
258594008581	dimer interface [polypeptide binding]; other site
258594008582	ATP binding site [chemical binding]; other site
258594008583	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
258594008584	active site
258594008585	metal binding site [ion binding]; metal-binding site
258594008586	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
258594008587	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
258594008588	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
258594008589	4 probable transmembrane helices predicted byTMHMM2.0
258594008590	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
258594008591	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
258594008592	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
258594008593	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
258594008594	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
258594008595	Methyltransferase domain; Region: Methyltransf_23; pfam13489
258594008596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594008597	S-adenosylmethionine binding site [chemical binding]; other site
258594008598	B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013
258594008599	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594008600	Radical SAM superfamily; Region: Radical_SAM; pfam04055
258594008601	FeS/SAM binding site; other site
258594008602	4 probable transmembrane helices predicted byTMHMM2.0
258594008603	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
258594008604	homotrimer interaction site [polypeptide binding]; other site
258594008605	putative active site [active]
258594008606	Transcriptional regulators [Transcription]; Region: GntR; COG1802
258594008607	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
258594008608	DNA-binding site [nucleotide binding]; DNA binding site
258594008609	FCD domain; Region: FCD; pfam07729
258594008610	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
258594008611	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
258594008612	Walker A/P-loop; other site
258594008613	ATP binding site [chemical binding]; other site
258594008614	Q-loop/lid; other site
258594008615	ABC transporter signature motif; other site
258594008616	Walker B; other site
258594008617	D-loop; other site
258594008618	H-loop/switch region; other site
258594008619	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
258594008620	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594008621	dimer interface [polypeptide binding]; other site
258594008622	conserved gate region; other site
258594008623	putative PBP binding loops; other site
258594008624	ABC-ATPase subunit interface; other site
258594008625	6 probable transmembrane helices predicted byTMHMM2.0
258594008626	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
258594008627	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
258594008628	1 probable transmembrane helix predicted byTMHMM2.0
258594008629	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
258594008630	Amidase; Region: Amidase; cl11426
258594008631	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
258594008632	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
258594008633	1 probable transmembrane helix predicted byTMHMM2.0
258594008634	aminotransferase; Validated; Region: PRK09148
258594008635	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
258594008636	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594008637	homodimer interface [polypeptide binding]; other site
258594008638	catalytic residue [active]
258594008639	homoserine dehydrogenase; Provisional; Region: PRK06349
258594008640	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
258594008641	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
258594008642	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
258594008643	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
258594008644	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
258594008645	putative active site [active]
258594008646	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
258594008647	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594008648	Coenzyme A binding pocket [chemical binding]; other site
258594008649	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
258594008650	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594008651	motif II; other site
258594008652	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
258594008653	DHH family; Region: DHH; pfam01368
258594008654	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
258594008655	10 probable transmembrane helices predicted byTMHMM2.0
258594008656	lytic murein transglycosylase; Region: MltB_2; TIGR02283
258594008657	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
258594008658	N-acetyl-D-glucosamine binding site [chemical binding]; other site
258594008659	catalytic residue [active]
258594008660	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
258594008661	putative lipid kinase; Reviewed; Region: PRK13057
258594008662	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
258594008663	elongation factor P; Validated; Region: PRK00529
258594008664	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
258594008665	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
258594008666	RNA binding site [nucleotide binding]; other site
258594008667	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
258594008668	RNA binding site [nucleotide binding]; other site
258594008669	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
258594008670	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
258594008671	motif 1; other site
258594008672	dimer interface [polypeptide binding]; other site
258594008673	active site
258594008674	motif 2; other site
258594008675	motif 3; other site
258594008676	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
258594008677	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594008678	FeS/SAM binding site; other site
258594008679	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
258594008680	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
258594008681	6 probable transmembrane helices predicted byTMHMM2.0
258594008682	1 probable transmembrane helix predicted byTMHMM2.0
258594008683	PilZ domain; Region: PilZ; pfam07238
258594008684	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
258594008685	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
258594008686	dimer interface [polypeptide binding]; other site
258594008687	active site
258594008688	metal binding site [ion binding]; metal-binding site
258594008689	glutathione binding site [chemical binding]; other site
258594008690	NAD-dependent deacetylase; Provisional; Region: PRK00481
258594008691	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
258594008692	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
258594008693	DNA-binding site [nucleotide binding]; DNA binding site
258594008694	RNA-binding motif; other site
258594008695	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
258594008696	DNA-binding site [nucleotide binding]; DNA binding site
258594008697	RNA-binding motif; other site
258594008698	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
258594008699	1 probable transmembrane helix predicted byTMHMM2.0
258594008700	single-stranded DNA-binding protein; Region: PHA00458
258594008701	3 probable transmembrane helices predicted byTMHMM2.0
258594008702	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
258594008703	DNA binding site [nucleotide binding]
258594008704	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
258594008705	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
258594008706	OpgC protein; Region: OpgC_C; pfam10129
258594008707	Acyltransferase family; Region: Acyl_transf_3; pfam01757
258594008708	9 probable transmembrane helices predicted byTMHMM2.0
258594008709	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
258594008710	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
258594008711	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
258594008712	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
258594008713	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
258594008714	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
258594008715	ATP-grasp domain; Region: ATP-grasp_4; cl17255
258594008716	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
258594008717	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
258594008718	carboxyltransferase (CT) interaction site; other site
258594008719	biotinylation site [posttranslational modification]; other site
258594008720	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
258594008721	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
258594008722	active site
258594008723	catalytic residues [active]
258594008724	metal binding site [ion binding]; metal-binding site
258594008725	DctM-like transporters; Region: DctM; pfam06808
258594008726	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
258594008727	11 probable transmembrane helices predicted byTMHMM2.0
258594008728	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
258594008729	4 probable transmembrane helices predicted byTMHMM2.0
258594008730	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
258594008731	1 probable transmembrane helix predicted byTMHMM2.0
258594008732	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
258594008733	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
258594008734	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
258594008735	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
258594008736	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
258594008737	Uncharacterized conserved protein [Function unknown]; Region: COG2966
258594008738	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
258594008739	2 probable transmembrane helices predicted byTMHMM2.0
258594008740	5 probable transmembrane helices predicted byTMHMM2.0
258594008741	PEGA domain; Region: PEGA; pfam08308
258594008742	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
258594008743	MG2 domain; Region: A2M_N; pfam01835
258594008744	Alpha-2-macroglobulin family; Region: A2M; pfam00207
258594008745	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
258594008746	surface patch; other site
258594008747	thioester region; other site
258594008748	specificity defining residues; other site
258594008749	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
258594008750	Transglycosylase; Region: Transgly; pfam00912
258594008751	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
258594008752	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
258594008753	1 probable transmembrane helix predicted byTMHMM2.0
258594008754	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
258594008755	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
258594008756	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
258594008757	12 probable transmembrane helices predicted byTMHMM2.0
258594008758	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
258594008759	active site
258594008760	6 probable transmembrane helices predicted byTMHMM2.0
258594008761	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
258594008762	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
258594008763	Ligand binding site; other site
258594008764	Putative Catalytic site; other site
258594008765	DXD motif; other site
258594008766	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
258594008767	3 probable transmembrane helices predicted byTMHMM2.0
258594008768	cystathionine beta-lyase; Provisional; Region: PRK05967
258594008769	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
258594008770	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594008771	catalytic residue [active]
258594008772	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
258594008773	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
258594008774	substrate binding pocket [chemical binding]; other site
258594008775	membrane-bound complex binding site; other site
258594008776	hinge residues; other site
258594008777	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
258594008778	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594008779	conserved gate region; other site
258594008780	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594008781	dimer interface [polypeptide binding]; other site
258594008782	ABC-ATPase subunit interface; other site
258594008783	putative PBP binding loops; other site
258594008784	9 probable transmembrane helices predicted byTMHMM2.0
258594008785	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594008786	dimer interface [polypeptide binding]; other site
258594008787	conserved gate region; other site
258594008788	putative PBP binding loops; other site
258594008789	ABC-ATPase subunit interface; other site
258594008790	11 probable transmembrane helices predicted byTMHMM2.0
258594008791	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
258594008792	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
258594008793	Walker A/P-loop; other site
258594008794	ATP binding site [chemical binding]; other site
258594008795	Q-loop/lid; other site
258594008796	ABC transporter signature motif; other site
258594008797	Walker B; other site
258594008798	D-loop; other site
258594008799	H-loop/switch region; other site
258594008800	1 probable transmembrane helix predicted byTMHMM2.0
258594008801	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
258594008802	AAA domain; Region: AAA_21; pfam13304
258594008803	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594008804	Q-loop/lid; other site
258594008805	ABC transporter signature motif; other site
258594008806	Walker B; other site
258594008807	D-loop; other site
258594008808	H-loop/switch region; other site
258594008809	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
258594008810	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
258594008811	dimer interface [polypeptide binding]; other site
258594008812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594008813	catalytic residue [active]
258594008814	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
258594008815	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594008816	S-adenosylmethionine binding site [chemical binding]; other site
258594008817	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
258594008818	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
258594008819	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
258594008820	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
258594008821	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594008822	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594008823	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594008824	1 probable transmembrane helix predicted byTMHMM2.0
258594008825	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
258594008826	Protein export membrane protein; Region: SecD_SecF; cl14618
258594008827	10 probable transmembrane helices predicted byTMHMM2.0
258594008828	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
258594008829	12 probable transmembrane helices predicted byTMHMM2.0
258594008830	DTW domain; Region: DTW; cl01221
258594008831	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
258594008832	9 probable transmembrane helices predicted byTMHMM2.0
258594008833	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
258594008834	1 probable transmembrane helix predicted byTMHMM2.0
258594008835	2 probable transmembrane helices predicted byTMHMM2.0
258594008836	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
258594008837	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594008838	S-adenosylmethionine binding site [chemical binding]; other site
258594008839	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
258594008840	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
258594008841	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
258594008842	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
258594008843	HIGH motif; other site
258594008844	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
258594008845	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
258594008846	active site
258594008847	KMSKS motif; other site
258594008848	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
258594008849	tRNA binding surface [nucleotide binding]; other site
258594008850	anticodon binding site; other site
258594008851	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
258594008852	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
258594008853	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
258594008854	6 probable transmembrane helices predicted byTMHMM2.0
258594008855	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
258594008856	active site
258594008857	DNA binding site [nucleotide binding]
258594008858	lipoyl synthase; Provisional; Region: PRK05481
258594008859	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594008860	FeS/SAM binding site; other site
258594008861	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
258594008862	putative coenzyme Q binding site [chemical binding]; other site
258594008863	Competence-damaged protein; Region: CinA; pfam02464
258594008864	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
258594008865	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
258594008866	substrate binding site; other site
258594008867	dimer interface; other site
258594008868	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
258594008869	homotrimer interaction site [polypeptide binding]; other site
258594008870	zinc binding site [ion binding]; other site
258594008871	CDP-binding sites; other site
258594008872	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
258594008873	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
258594008874	FMN binding site [chemical binding]; other site
258594008875	active site
258594008876	catalytic residues [active]
258594008877	substrate binding site [chemical binding]; other site
258594008878	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
258594008879	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594008880	putative active site [active]
258594008881	heme pocket [chemical binding]; other site
258594008882	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594008883	dimer interface [polypeptide binding]; other site
258594008884	phosphorylation site [posttranslational modification]
258594008885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594008886	ATP binding site [chemical binding]; other site
258594008887	Mg2+ binding site [ion binding]; other site
258594008888	G-X-G motif; other site
258594008889	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
258594008890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594008891	active site
258594008892	phosphorylation site [posttranslational modification]
258594008893	intermolecular recognition site; other site
258594008894	dimerization interface [polypeptide binding]; other site
258594008895	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594008896	Walker A motif; other site
258594008897	ATP binding site [chemical binding]; other site
258594008898	Walker B motif; other site
258594008899	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
258594008900	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
258594008901	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
258594008902	dimerization interface [polypeptide binding]; other site
258594008903	PAS domain; Region: PAS; smart00091
258594008904	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594008905	dimer interface [polypeptide binding]; other site
258594008906	phosphorylation site [posttranslational modification]
258594008907	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594008908	ATP binding site [chemical binding]; other site
258594008909	Mg2+ binding site [ion binding]; other site
258594008910	G-X-G motif; other site
258594008911	5 probable transmembrane helices predicted byTMHMM2.0
258594008912	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
258594008913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594008914	active site
258594008915	phosphorylation site [posttranslational modification]
258594008916	intermolecular recognition site; other site
258594008917	dimerization interface [polypeptide binding]; other site
258594008918	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594008919	Walker A motif; other site
258594008920	ATP binding site [chemical binding]; other site
258594008921	Walker B motif; other site
258594008922	arginine finger; other site
258594008923	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
258594008924	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
258594008925	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
258594008926	homodimer interface [polypeptide binding]; other site
258594008927	substrate-cofactor binding pocket; other site
258594008928	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594008929	catalytic residue [active]
258594008930	bacterial Hfq-like; Region: Hfq; cd01716
258594008931	hexamer interface [polypeptide binding]; other site
258594008932	Sm1 motif; other site
258594008933	RNA binding site [nucleotide binding]; other site
258594008934	Sm2 motif; other site
258594008935	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
258594008936	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
258594008937	HflX GTPase family; Region: HflX; cd01878
258594008938	G1 box; other site
258594008939	GTP/Mg2+ binding site [chemical binding]; other site
258594008940	Switch I region; other site
258594008941	G2 box; other site
258594008942	G3 box; other site
258594008943	Switch II region; other site
258594008944	G4 box; other site
258594008945	G5 box; other site
258594008946	DNA gyrase subunit A; Validated; Region: PRK05560
258594008947	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
258594008948	CAP-like domain; other site
258594008949	active site
258594008950	primary dimer interface [polypeptide binding]; other site
258594008951	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
258594008952	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
258594008953	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
258594008954	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
258594008955	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
258594008956	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
258594008957	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
258594008958	active site
258594008959	(T/H)XGH motif; other site
258594008960	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
258594008961	active site
258594008962	Gram-negative bacterial tonB protein; Region: TonB; cl10048
258594008963	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
258594008964	active site
258594008965	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
258594008966	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
258594008967	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
258594008968	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
258594008969	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
258594008970	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594008971	non-specific DNA binding site [nucleotide binding]; other site
258594008972	salt bridge; other site
258594008973	sequence-specific DNA binding site [nucleotide binding]; other site
258594008974	Cupin domain; Region: Cupin_2; pfam07883
258594008975	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
258594008976	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
258594008977	substrate binding pocket [chemical binding]; other site
258594008978	membrane-bound complex binding site; other site
258594008979	hinge residues; other site
258594008980	1 probable transmembrane helix predicted byTMHMM2.0
258594008981	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
258594008982	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
258594008983	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
258594008984	Walker A/P-loop; other site
258594008985	ATP binding site [chemical binding]; other site
258594008986	Q-loop/lid; other site
258594008987	ABC transporter signature motif; other site
258594008988	Walker B; other site
258594008989	D-loop; other site
258594008990	H-loop/switch region; other site
258594008991	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
258594008992	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594008993	dimer interface [polypeptide binding]; other site
258594008994	conserved gate region; other site
258594008995	putative PBP binding loops; other site
258594008996	ABC-ATPase subunit interface; other site
258594008997	7 probable transmembrane helices predicted byTMHMM2.0
258594008998	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
258594008999	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
258594009000	active site
258594009001	dimer interface [polypeptide binding]; other site
258594009002	non-prolyl cis peptide bond; other site
258594009003	insertion regions; other site
258594009004	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
258594009005	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
258594009006	membrane-bound complex binding site; other site
258594009007	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
258594009008	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
258594009009	nitrogenase iron protein; Region: nifH; TIGR01287
258594009010	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
258594009011	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
258594009012	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
258594009013	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
258594009014	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
258594009015	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
258594009016	substrate binding pocket [chemical binding]; other site
258594009017	membrane-bound complex binding site; other site
258594009018	choline dehydrogenase; Validated; Region: PRK02106
258594009019	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
258594009020	Putative mono-oxygenase ydhR; Region: ydhR; cl07420
258594009021	OsmC-like protein; Region: OsmC; pfam02566
258594009022	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
258594009023	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
258594009024	Walker A/P-loop; other site
258594009025	ATP binding site [chemical binding]; other site
258594009026	Q-loop/lid; other site
258594009027	ABC transporter signature motif; other site
258594009028	Walker B; other site
258594009029	D-loop; other site
258594009030	H-loop/switch region; other site
258594009031	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
258594009032	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594009033	dimer interface [polypeptide binding]; other site
258594009034	conserved gate region; other site
258594009035	putative PBP binding loops; other site
258594009036	ABC-ATPase subunit interface; other site
258594009037	5 probable transmembrane helices predicted byTMHMM2.0
258594009038	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
258594009039	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
258594009040	substrate binding pocket [chemical binding]; other site
258594009041	membrane-bound complex binding site; other site
258594009042	hinge residues; other site
258594009043	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
258594009044	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
258594009045	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594009046	catalytic residue [active]
258594009047	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
258594009048	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
258594009049	catalytic site [active]
258594009050	1 probable transmembrane helix predicted byTMHMM2.0
258594009051	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
258594009052	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
258594009053	substrate binding pocket [chemical binding]; other site
258594009054	catalytic triad [active]
258594009055	1 probable transmembrane helix predicted byTMHMM2.0
258594009056	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
258594009057	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
258594009058	substrate binding pocket [chemical binding]; other site
258594009059	membrane-bound complex binding site; other site
258594009060	hinge residues; other site
258594009061	1 probable transmembrane helix predicted byTMHMM2.0
258594009062	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
258594009063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
258594009064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594009065	dimer interface [polypeptide binding]; other site
258594009066	putative PBP binding loops; other site
258594009067	ABC-ATPase subunit interface; other site
258594009068	7 probable transmembrane helices predicted byTMHMM2.0
258594009069	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
258594009070	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594009071	dimer interface [polypeptide binding]; other site
258594009072	conserved gate region; other site
258594009073	putative PBP binding loops; other site
258594009074	ABC-ATPase subunit interface; other site
258594009075	9 probable transmembrane helices predicted byTMHMM2.0
258594009076	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
258594009077	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
258594009078	1 probable transmembrane helix predicted byTMHMM2.0
258594009079	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
258594009080	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594009081	dimer interface [polypeptide binding]; other site
258594009082	conserved gate region; other site
258594009083	putative PBP binding loops; other site
258594009084	ABC-ATPase subunit interface; other site
258594009085	8 probable transmembrane helices predicted byTMHMM2.0
258594009086	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
258594009087	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
258594009088	Walker A/P-loop; other site
258594009089	ATP binding site [chemical binding]; other site
258594009090	Q-loop/lid; other site
258594009091	ABC transporter signature motif; other site
258594009092	Walker B; other site
258594009093	D-loop; other site
258594009094	H-loop/switch region; other site
258594009095	Radical SAM superfamily; Region: Radical_SAM; pfam04055
258594009096	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594009097	FeS/SAM binding site; other site
258594009098	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
258594009099	nitrogenase iron protein; Region: nifH; TIGR01287
258594009100	Nucleotide-binding sites [chemical binding]; other site
258594009101	Walker A motif; other site
258594009102	Switch I region of nucleotide binding site; other site
258594009103	Fe4S4 binding sites [ion binding]; other site
258594009104	Switch II region of nucleotide binding site; other site
258594009105	Nitrogenase_VnfE_like: VnfE subunit of the VnfEN complex_like. This group in addition to VnfE contains a subset of the alpha subunit of the nitrogenase MoFe protein and NifE-like proteins.  The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfE_like; cd01972
258594009106	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
258594009107	Nitrogenase_vnfN_like: VnfN subunit of the VnfEN complex-like.  This group in addition to VnfN contains a subset of the beta subunit of the nitrogenase MoFe protein and NifN-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfN_like; cd01971
258594009108	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
258594009109	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
258594009110	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
258594009111	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
258594009112	Isochorismatase family; Region: Isochorismatase; pfam00857
258594009113	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
258594009114	catalytic triad [active]
258594009115	conserved cis-peptide bond; other site
258594009116	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
258594009117	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
258594009118	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
258594009119	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594009120	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
258594009121	dimerization interface [polypeptide binding]; other site
258594009122	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
258594009123	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594009124	Walker A/P-loop; other site
258594009125	ATP binding site [chemical binding]; other site
258594009126	Q-loop/lid; other site
258594009127	ABC transporter signature motif; other site
258594009128	Walker B; other site
258594009129	D-loop; other site
258594009130	H-loop/switch region; other site
258594009131	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
258594009132	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594009133	Walker A/P-loop; other site
258594009134	ATP binding site [chemical binding]; other site
258594009135	Q-loop/lid; other site
258594009136	ABC transporter signature motif; other site
258594009137	Walker B; other site
258594009138	D-loop; other site
258594009139	H-loop/switch region; other site
258594009140	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
258594009141	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
258594009142	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594009143	dimer interface [polypeptide binding]; other site
258594009144	conserved gate region; other site
258594009145	putative PBP binding loops; other site
258594009146	ABC-ATPase subunit interface; other site
258594009147	5 probable transmembrane helices predicted byTMHMM2.0
258594009148	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
258594009149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594009150	dimer interface [polypeptide binding]; other site
258594009151	conserved gate region; other site
258594009152	putative PBP binding loops; other site
258594009153	ABC-ATPase subunit interface; other site
258594009154	6 probable transmembrane helices predicted byTMHMM2.0
258594009155	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
258594009156	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
258594009157	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
258594009158	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
258594009159	metal binding site [ion binding]; metal-binding site
258594009160	putative dimer interface [polypeptide binding]; other site
258594009161	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
258594009162	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
258594009163	active site
258594009164	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
258594009165	EamA-like transporter family; Region: EamA; pfam00892
258594009166	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
258594009167	EamA-like transporter family; Region: EamA; pfam00892
258594009168	7 probable transmembrane helices predicted byTMHMM2.0
258594009169	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
258594009170	homotrimer interaction site [polypeptide binding]; other site
258594009171	putative active site [active]
258594009172	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
258594009173	1 probable transmembrane helix predicted byTMHMM2.0
258594009174	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
258594009175	1 probable transmembrane helix predicted byTMHMM2.0
258594009176	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
258594009177	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
258594009178	NdvC_like  proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435
258594009179	Ligand binding site; other site
258594009180	DXD motif; other site
258594009181	8 probable transmembrane helices predicted byTMHMM2.0
258594009182	1 probable transmembrane helix predicted byTMHMM2.0
258594009183	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
258594009184	8 probable transmembrane helices predicted byTMHMM2.0
258594009185	1 probable transmembrane helix predicted byTMHMM2.0
258594009186	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
258594009187	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
258594009188	Substrate binding site; other site
258594009189	Mg++ binding site; other site
258594009190	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
258594009191	active site
258594009192	substrate binding site [chemical binding]; other site
258594009193	CoA binding site [chemical binding]; other site
258594009194	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
258594009195	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
258594009196	glutaminase active site [active]
258594009197	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
258594009198	dimer interface [polypeptide binding]; other site
258594009199	active site
258594009200	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
258594009201	dimer interface [polypeptide binding]; other site
258594009202	active site
258594009203	Uncharacterized conserved protein [Function unknown]; Region: COG2928
258594009204	2 probable transmembrane helices predicted byTMHMM2.0
258594009205	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
258594009206	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
258594009207	generic binding surface II; other site
258594009208	ssDNA binding site; other site
258594009209	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
258594009210	ATP binding site [chemical binding]; other site
258594009211	putative Mg++ binding site [ion binding]; other site
258594009212	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
258594009213	nucleotide binding region [chemical binding]; other site
258594009214	ATP-binding site [chemical binding]; other site
258594009215	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
258594009216	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
258594009217	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
258594009218	ATP binding site [chemical binding]; other site
258594009219	putative Mg++ binding site [ion binding]; other site
258594009220	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
258594009221	nucleotide binding region [chemical binding]; other site
258594009222	ATP-binding site [chemical binding]; other site
258594009223	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
258594009224	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
258594009225	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594009226	acyl-activating enzyme (AAE) consensus motif; other site
258594009227	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
258594009228	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
258594009229	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
258594009230	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
258594009231	Predicted permeases [General function prediction only]; Region: COG0679
258594009232	10 probable transmembrane helices predicted byTMHMM2.0
258594009233	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
258594009234	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
258594009235	1 probable transmembrane helix predicted byTMHMM2.0
258594009236	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
258594009237	7 probable transmembrane helices predicted byTMHMM2.0
258594009238	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
258594009239	7 probable transmembrane helices predicted byTMHMM2.0
258594009240	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
258594009241	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
258594009242	NADP binding site [chemical binding]; other site
258594009243	dimer interface [polypeptide binding]; other site
258594009244	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
258594009245	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
258594009246	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594009247	FeS/SAM binding site; other site
258594009248	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594009249	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594009250	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
258594009251	dimerization interface [polypeptide binding]; other site
258594009252	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
258594009253	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
258594009254	membrane-bound complex binding site; other site
258594009255	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
258594009256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594009257	dimer interface [polypeptide binding]; other site
258594009258	conserved gate region; other site
258594009259	putative PBP binding loops; other site
258594009260	ABC-ATPase subunit interface; other site
258594009261	6 probable transmembrane helices predicted byTMHMM2.0
258594009262	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
258594009263	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
258594009264	Walker A/P-loop; other site
258594009265	ATP binding site [chemical binding]; other site
258594009266	Q-loop/lid; other site
258594009267	ABC transporter signature motif; other site
258594009268	Walker B; other site
258594009269	D-loop; other site
258594009270	H-loop/switch region; other site
258594009271	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
258594009272	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
258594009273	putative active site [active]
258594009274	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
258594009275	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
258594009276	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
258594009277	hypothetical protein; Validated; Region: PRK08245
258594009278	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
258594009279	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
258594009280	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
258594009281	dimer interface [polypeptide binding]; other site
258594009282	active site
258594009283	catalytic residue [active]
258594009284	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
258594009285	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
258594009286	2 probable transmembrane helices predicted byTMHMM2.0
258594009287	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
258594009288	SmpB-tmRNA interface; other site
258594009289	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
258594009290	catalytic triad [active]
258594009291	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
258594009292	Fe-S cluster binding site [ion binding]; other site
258594009293	DNA binding site [nucleotide binding]
258594009294	active site
258594009295	LabA_like proteins; Region: LabA; cd10911
258594009296	Uncharacterized conserved protein [Function unknown]; Region: COG1432
258594009297	putative metal binding site [ion binding]; other site
258594009298	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
258594009299	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
258594009300	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
258594009301	Zn2+ binding site [ion binding]; other site
258594009302	Mg2+ binding site [ion binding]; other site
258594009303	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
258594009304	synthetase active site [active]
258594009305	NTP binding site [chemical binding]; other site
258594009306	metal binding site [ion binding]; metal-binding site
258594009307	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
258594009308	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
258594009309	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
258594009310	active site
258594009311	hydrophilic channel; other site
258594009312	dimerization interface [polypeptide binding]; other site
258594009313	catalytic residues [active]
258594009314	active site lid [active]
258594009315	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
258594009316	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
258594009317	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
258594009318	Catalytic site [active]
258594009319	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
258594009320	1 probable transmembrane helix predicted byTMHMM2.0
258594009321	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
258594009322	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
258594009323	dimerization interface [polypeptide binding]; other site
258594009324	active site
258594009325	metal binding site [ion binding]; metal-binding site
258594009326	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
258594009327	dsRNA binding site [nucleotide binding]; other site
258594009328	GTPase Era; Reviewed; Region: era; PRK00089
258594009329	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
258594009330	G1 box; other site
258594009331	GTP/Mg2+ binding site [chemical binding]; other site
258594009332	Switch I region; other site
258594009333	G2 box; other site
258594009334	Switch II region; other site
258594009335	G3 box; other site
258594009336	G4 box; other site
258594009337	G5 box; other site
258594009338	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
258594009339	4 probable transmembrane helices predicted byTMHMM2.0
258594009340	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
258594009341	Recombination protein O N terminal; Region: RecO_N; pfam11967
258594009342	Recombination protein O C terminal; Region: RecO_C; pfam02565
258594009343	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594009344	NmrA-like family; Region: NmrA; pfam05368
258594009345	NAD(P) binding site [chemical binding]; other site
258594009346	active site
258594009347	Predicted transcriptional regulators [Transcription]; Region: COG1733
258594009348	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
258594009349	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
258594009350	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
258594009351	CAP-like domain; other site
258594009352	active site
258594009353	primary dimer interface [polypeptide binding]; other site
258594009354	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
258594009355	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
258594009356	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
258594009357	transmembrane helices; other site
258594009358	11 probable transmembrane helices predicted byTMHMM2.0
258594009359	1 probable transmembrane helix predicted byTMHMM2.0
258594009360	manganese transport protein MntH; Reviewed; Region: PRK00701
258594009361	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
258594009362	11 probable transmembrane helices predicted byTMHMM2.0
258594009363	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
258594009364	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
258594009365	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594009366	Fusaric acid resistance protein family; Region: FUSC; pfam04632
258594009367	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
258594009368	9 probable transmembrane helices predicted byTMHMM2.0
258594009369	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
258594009370	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
258594009371	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594009372	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594009373	1 probable transmembrane helix predicted byTMHMM2.0
258594009374	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
258594009375	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
258594009376	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
258594009377	Predicted membrane protein/domain [Function unknown]; Region: COG1714
258594009378	3 probable transmembrane helices predicted byTMHMM2.0
258594009379	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
258594009380	dimer interface [polypeptide binding]; other site
258594009381	allosteric magnesium binding site [ion binding]; other site
258594009382	active site
258594009383	aspartate-rich active site metal binding site; other site
258594009384	Schiff base residues; other site
258594009385	4 probable transmembrane helices predicted byTMHMM2.0
258594009386	acyl-CoA synthetase; Validated; Region: PRK06188
258594009387	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
258594009388	acyl-activating enzyme (AAE) consensus motif; other site
258594009389	putative AMP binding site [chemical binding]; other site
258594009390	putative active site [active]
258594009391	putative CoA binding site [chemical binding]; other site
258594009392	Transcriptional regulators [Transcription]; Region: MarR; COG1846
258594009393	MarR family; Region: MarR_2; cl17246
258594009394	Domain of unknown function (DUF4142); Region: DUF4142; cl17876
258594009395	1 probable transmembrane helix predicted byTMHMM2.0
258594009396	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
258594009397	apolar tunnel; other site
258594009398	heme binding site [chemical binding]; other site
258594009399	dimerization interface [polypeptide binding]; other site
258594009400	putative S-transferase; Provisional; Region: PRK11752
258594009401	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
258594009402	C-terminal domain interface [polypeptide binding]; other site
258594009403	GSH binding site (G-site) [chemical binding]; other site
258594009404	dimer interface [polypeptide binding]; other site
258594009405	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
258594009406	dimer interface [polypeptide binding]; other site
258594009407	N-terminal domain interface [polypeptide binding]; other site
258594009408	active site
258594009409	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
258594009410	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
258594009411	nudix motif; other site
258594009412	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
258594009413	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
258594009414	dimer interface [polypeptide binding]; other site
258594009415	active site
258594009416	glycine-pyridoxal phosphate binding site [chemical binding]; other site
258594009417	folate binding site [chemical binding]; other site
258594009418	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
258594009419	ATP cone domain; Region: ATP-cone; pfam03477
258594009420	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
258594009421	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
258594009422	catalytic motif [active]
258594009423	Zn binding site [ion binding]; other site
258594009424	RibD C-terminal domain; Region: RibD_C; cl17279
258594009425	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
258594009426	Lumazine binding domain; Region: Lum_binding; pfam00677
258594009427	Lumazine binding domain; Region: Lum_binding; pfam00677
258594009428	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
258594009429	homopentamer interface [polypeptide binding]; other site
258594009430	active site
258594009431	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
258594009432	putative RNA binding site [nucleotide binding]; other site
258594009433	thiamine monophosphate kinase; Provisional; Region: PRK05731
258594009434	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
258594009435	ATP binding site [chemical binding]; other site
258594009436	dimerization interface [polypeptide binding]; other site
258594009437	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
258594009438	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
258594009439	15 probable transmembrane helices predicted byTMHMM2.0
258594009440	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
258594009441	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
258594009442	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
258594009443	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
258594009444	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594009445	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594009446	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
258594009447	Protein export membrane protein; Region: SecD_SecF; cl14618
258594009448	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
258594009449	11 probable transmembrane helices predicted byTMHMM2.0
258594009450	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
258594009451	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
258594009452	1 probable transmembrane helix predicted byTMHMM2.0
258594009453	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981
258594009454	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
258594009455	putative phosphate acyltransferase; Provisional; Region: PRK05331
258594009456	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
258594009457	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
258594009458	dimer interface [polypeptide binding]; other site
258594009459	active site
258594009460	CoA binding pocket [chemical binding]; other site
258594009461	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
258594009462	IHF dimer interface [polypeptide binding]; other site
258594009463	IHF - DNA interface [nucleotide binding]; other site
258594009464	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
258594009465	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
258594009466	DNA binding residues [nucleotide binding]
258594009467	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
258594009468	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594009469	N-terminal plug; other site
258594009470	ligand-binding site [chemical binding]; other site
258594009471	3 probable transmembrane helices predicted byTMHMM2.0
258594009472	3 probable transmembrane helices predicted byTMHMM2.0
258594009473	classical (c) SDRs; Region: SDR_c; cd05233
258594009474	short chain dehydrogenase; Provisional; Region: PRK05650
258594009475	NAD(P) binding site [chemical binding]; other site
258594009476	active site
258594009477	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
258594009478	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
258594009479	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
258594009480	5 probable transmembrane helices predicted byTMHMM2.0
258594009481	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
258594009482	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
258594009483	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
258594009484	Chain length determinant protein; Region: Wzz; pfam02706
258594009485	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
258594009486	1 probable transmembrane helix predicted byTMHMM2.0
258594009487	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
258594009488	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
258594009489	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
258594009490	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
258594009491	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
258594009492	putative active site [active]
258594009493	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
258594009494	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
258594009495	dimerization interface [polypeptide binding]; other site
258594009496	DPS ferroxidase diiron center [ion binding]; other site
258594009497	ion pore; other site
258594009498	1 probable transmembrane helix predicted byTMHMM2.0
258594009499	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
258594009500	2 probable transmembrane helices predicted byTMHMM2.0
258594009501	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
258594009502	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
258594009503	8 probable transmembrane helices predicted byTMHMM2.0
258594009504	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594009505	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594009506	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
258594009507	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
258594009508	PYR/PP interface [polypeptide binding]; other site
258594009509	dimer interface [polypeptide binding]; other site
258594009510	TPP binding site [chemical binding]; other site
258594009511	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
258594009512	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
258594009513	TPP-binding site; other site
258594009514	dimer interface [polypeptide binding]; other site
258594009515	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594009516	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
258594009517	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
258594009518	5 probable transmembrane helices predicted byTMHMM2.0
258594009519	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
258594009520	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
258594009521	homodimer interface [polypeptide binding]; other site
258594009522	substrate-cofactor binding pocket; other site
258594009523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594009524	catalytic residue [active]
258594009525	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
258594009526	enoyl-CoA hydratase; Validated; Region: PRK08139
258594009527	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594009528	substrate binding site [chemical binding]; other site
258594009529	oxyanion hole (OAH) forming residues; other site
258594009530	trimer interface [polypeptide binding]; other site
258594009531	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
258594009532	CoenzymeA binding site [chemical binding]; other site
258594009533	subunit interaction site [polypeptide binding]; other site
258594009534	PHB binding site; other site
258594009535	1 probable transmembrane helix predicted byTMHMM2.0
258594009536	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
258594009537	23S rRNA interface [nucleotide binding]; other site
258594009538	L3 interface [polypeptide binding]; other site
258594009539	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
258594009540	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594009541	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594009542	metal binding site [ion binding]; metal-binding site
258594009543	active site
258594009544	I-site; other site
258594009545	7 probable transmembrane helices predicted byTMHMM2.0
258594009546	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
258594009547	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
258594009548	Domain of unknown function DUF20; Region: UPF0118; pfam01594
258594009549	8 probable transmembrane helices predicted byTMHMM2.0
258594009550	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
258594009551	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
258594009552	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
258594009553	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
258594009554	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
258594009555	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
258594009556	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
258594009557	1 probable transmembrane helix predicted byTMHMM2.0
258594009558	thymidylate kinase; Validated; Region: tmk; PRK00698
258594009559	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
258594009560	TMP-binding site; other site
258594009561	ATP-binding site [chemical binding]; other site
258594009562	DNA polymerase III subunit delta'; Validated; Region: PRK07471
258594009563	AAA ATPase domain; Region: AAA_16; pfam13191
258594009564	DNA polymerase III subunit delta'; Validated; Region: PRK08485
258594009565	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
258594009566	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
258594009567	active site
258594009568	HIGH motif; other site
258594009569	KMSKS motif; other site
258594009570	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
258594009571	tRNA binding surface [nucleotide binding]; other site
258594009572	anticodon binding site; other site
258594009573	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
258594009574	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
258594009575	active site
258594009576	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
258594009577	putative hydrolase; Provisional; Region: PRK02113
258594009578	acyl-CoA synthetase; Validated; Region: PRK08162
258594009579	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
258594009580	acyl-activating enzyme (AAE) consensus motif; other site
258594009581	putative active site [active]
258594009582	AMP binding site [chemical binding]; other site
258594009583	putative CoA binding site [chemical binding]; other site
258594009584	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
258594009585	DctM-like transporters; Region: DctM; pfam06808
258594009586	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
258594009587	17 probable transmembrane helices predicted byTMHMM2.0
258594009588	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
258594009589	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
258594009590	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
258594009591	5 probable transmembrane helices predicted byTMHMM2.0
258594009592	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
258594009593	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
258594009594	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
258594009595	FAD binding pocket [chemical binding]; other site
258594009596	FAD binding motif [chemical binding]; other site
258594009597	phosphate binding motif [ion binding]; other site
258594009598	beta-alpha-beta structure motif; other site
258594009599	NAD binding pocket [chemical binding]; other site
258594009600	6 probable transmembrane helices predicted byTMHMM2.0
258594009601	PAS domain; Region: PAS_9; pfam13426
258594009602	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594009603	putative active site [active]
258594009604	heme pocket [chemical binding]; other site
258594009605	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
258594009606	HWE histidine kinase; Region: HWE_HK; smart00911
258594009607	Methyltransferase domain; Region: Methyltransf_31; pfam13847
258594009608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594009609	S-adenosylmethionine binding site [chemical binding]; other site
258594009610	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
258594009611	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
258594009612	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
258594009613	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
258594009614	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
258594009615	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
258594009616	25 probable transmembrane helices predicted byTMHMM2.0
258594009617	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
258594009618	3 probable transmembrane helices predicted byTMHMM2.0
258594009619	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
258594009620	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
258594009621	14 probable transmembrane helices predicted byTMHMM2.0
258594009622	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
258594009623	2 probable transmembrane helices predicted byTMHMM2.0
258594009624	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
258594009625	3 probable transmembrane helices predicted byTMHMM2.0
258594009626	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
258594009627	3 probable transmembrane helices predicted byTMHMM2.0
258594009628	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
258594009629	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
258594009630	catalytic residue [active]
258594009631	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
258594009632	dimer interface [polypeptide binding]; other site
258594009633	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
258594009634	active site
258594009635	glycine-pyridoxal phosphate binding site [chemical binding]; other site
258594009636	folate binding site [chemical binding]; other site
258594009637	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
258594009638	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
258594009639	DNA-binding site [nucleotide binding]; DNA binding site
258594009640	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
258594009641	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594009642	homodimer interface [polypeptide binding]; other site
258594009643	catalytic residue [active]
258594009644	benzoate transporter; Region: benE; TIGR00843
258594009645	Benzoate membrane transport protein; Region: BenE; pfam03594
258594009646	11 probable transmembrane helices predicted byTMHMM2.0
258594009647	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
258594009648	dimer interface [polypeptide binding]; other site
258594009649	pyridoxamine kinase; Validated; Region: PRK05756
258594009650	pyridoxal binding site [chemical binding]; other site
258594009651	ATP binding site [chemical binding]; other site
258594009652	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
258594009653	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
258594009654	Part of AAA domain; Region: AAA_19; pfam13245
258594009655	Family description; Region: UvrD_C_2; pfam13538
258594009656	Putative mono-oxygenase ydhR; Region: ydhR; cl07420
258594009657	Protein of unknown function (DUF3187); Region: DUF3187; pfam11383
258594009658	1 probable transmembrane helix predicted byTMHMM2.0
258594009659	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
258594009660	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
258594009661	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
258594009662	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
258594009663	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
258594009664	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
258594009665	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
258594009666	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
258594009667	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
258594009668	Beta-lactamase; Region: Beta-lactamase; pfam00144
258594009669	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
258594009670	Ligand Binding Site [chemical binding]; other site
258594009671	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
258594009672	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
258594009673	homodimer interface [polypeptide binding]; other site
258594009674	metal binding site [ion binding]; metal-binding site
258594009675	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
258594009676	homodimer interface [polypeptide binding]; other site
258594009677	active site
258594009678	putative chemical substrate binding site [chemical binding]; other site
258594009679	metal binding site [ion binding]; metal-binding site
258594009680	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
258594009681	Domain of unknown function DUF21; Region: DUF21; pfam01595
258594009682	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
258594009683	Transporter associated domain; Region: CorC_HlyC; smart01091
258594009684	4 probable transmembrane helices predicted byTMHMM2.0
258594009685	2 probable transmembrane helices predicted byTMHMM2.0
258594009686	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
258594009687	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
258594009688	dimer interface [polypeptide binding]; other site
258594009689	ssDNA binding site [nucleotide binding]; other site
258594009690	tetramer (dimer of dimers) interface [polypeptide binding]; other site
258594009691	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
258594009692	1 probable transmembrane helix predicted byTMHMM2.0
258594009693	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
258594009694	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
258594009695	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
258594009696	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
258594009697	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
258594009698	1 probable transmembrane helix predicted byTMHMM2.0
258594009699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
258594009700	Protein of unknown function (DUF433); Region: DUF433; pfam04255
258594009701	Ion transport protein; Region: Ion_trans; pfam00520
258594009702	Ion channel; Region: Ion_trans_2; pfam07885
258594009703	4 probable transmembrane helices predicted byTMHMM2.0
258594009704	1 probable transmembrane helix predicted byTMHMM2.0
258594009705	Predicted acetyltransferase [General function prediction only]; Region: COG2388
258594009706	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
258594009707	CoenzymeA binding site [chemical binding]; other site
258594009708	subunit interaction site [polypeptide binding]; other site
258594009709	PHB binding site; other site
258594009710	1 probable transmembrane helix predicted byTMHMM2.0
258594009711	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
258594009712	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
258594009713	7 probable transmembrane helices predicted byTMHMM2.0
258594009714	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
258594009715	Glucose inhibited division protein A; Region: GIDA; pfam01134
258594009716	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
258594009717	substrate binding pocket [chemical binding]; other site
258594009718	substrate-Mg2+ binding site; other site
258594009719	aspartate-rich region 1; other site
258594009720	aspartate-rich region 2; other site
258594009721	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
258594009722	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
258594009723	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
258594009724	Protein export membrane protein; Region: SecD_SecF; pfam02355
258594009725	7 probable transmembrane helices predicted byTMHMM2.0
258594009726	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
258594009727	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
258594009728	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
258594009729	6 probable transmembrane helices predicted byTMHMM2.0
258594009730	Preprotein translocase subunit; Region: YajC; pfam02699
258594009731	1 probable transmembrane helix predicted byTMHMM2.0
258594009732	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
258594009733	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594009734	Walker A motif; other site
258594009735	ATP binding site [chemical binding]; other site
258594009736	Walker B motif; other site
258594009737	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
258594009738	Phospholipid methyltransferase; Region: PEMT; cl17370
258594009739	6 probable transmembrane helices predicted byTMHMM2.0
258594009740	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
258594009741	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
258594009742	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
258594009743	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
258594009744	Peptidase family M23; Region: Peptidase_M23; pfam01551
258594009745	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
258594009746	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594009747	S-adenosylmethionine binding site [chemical binding]; other site
258594009748	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594009749	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594009750	active site
258594009751	phosphorylation site [posttranslational modification]
258594009752	intermolecular recognition site; other site
258594009753	dimerization interface [polypeptide binding]; other site
258594009754	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
258594009755	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
258594009756	pseudo gene of Fe+3 siderophore transport receptor
258594009757	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
258594009758	1 probable transmembrane helix predicted byTMHMM2.0
258594009759	seryl-tRNA synthetase; Provisional; Region: PRK05431
258594009760	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
258594009761	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
258594009762	dimer interface [polypeptide binding]; other site
258594009763	active site
258594009764	motif 1; other site
258594009765	motif 2; other site
258594009766	motif 3; other site
258594009767	Autotransporter beta-domain; Region: Autotransporter; cl17461
258594009768	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
258594009769	6 probable transmembrane helices predicted byTMHMM2.0
258594009770	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
258594009771	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
258594009772	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
258594009773	1 probable transmembrane helix predicted byTMHMM2.0
258594009774	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
258594009775	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
258594009776	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
258594009777	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
258594009778	Sporulation related domain; Region: SPOR; pfam05036
258594009779	1 probable transmembrane helix predicted byTMHMM2.0
258594009780	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
258594009781	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
258594009782	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
258594009783	active site
258594009784	HIGH motif; other site
258594009785	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
258594009786	KMSK motif region; other site
258594009787	tRNA binding surface [nucleotide binding]; other site
258594009788	DALR anticodon binding domain; Region: DALR_1; smart00836
258594009789	anticodon binding site; other site
258594009790	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
258594009791	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
258594009792	Zn2+ binding site [ion binding]; other site
258594009793	Mg2+ binding site [ion binding]; other site
258594009794	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
258594009795	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
258594009796	2 probable transmembrane helices predicted byTMHMM2.0
258594009797	Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931
258594009798	4 probable transmembrane helices predicted byTMHMM2.0
258594009799	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
258594009800	putative catalytic site [active]
258594009801	putative phosphate binding site [ion binding]; other site
258594009802	active site
258594009803	metal binding site A [ion binding]; metal-binding site
258594009804	DNA binding site [nucleotide binding]
258594009805	putative AP binding site [nucleotide binding]; other site
258594009806	putative metal binding site B [ion binding]; other site
258594009807	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
258594009808	Sel1-like repeats; Region: SEL1; smart00671
258594009809	Sel1-like repeats; Region: SEL1; smart00671
258594009810	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
258594009811	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
258594009812	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
258594009813	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
258594009814	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
258594009815	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
258594009816	E3 interaction surface; other site
258594009817	lipoyl attachment site [posttranslational modification]; other site
258594009818	e3 binding domain; Region: E3_binding; pfam02817
258594009819	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
258594009820	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
258594009821	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
258594009822	E3 interaction surface; other site
258594009823	lipoyl attachment site [posttranslational modification]; other site
258594009824	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
258594009825	alpha subunit interface [polypeptide binding]; other site
258594009826	TPP binding site [chemical binding]; other site
258594009827	heterodimer interface [polypeptide binding]; other site
258594009828	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
258594009829	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
258594009830	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
258594009831	tetramer interface [polypeptide binding]; other site
258594009832	TPP-binding site [chemical binding]; other site
258594009833	heterodimer interface [polypeptide binding]; other site
258594009834	phosphorylation loop region [posttranslational modification]
258594009835	Septum formation initiator; Region: DivIC; pfam04977
258594009836	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
258594009837	1 probable transmembrane helix predicted byTMHMM2.0
258594009838	Predicted flavoprotein [General function prediction only]; Region: COG0431
258594009839	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
258594009840	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
258594009841	CoA-transferase family III; Region: CoA_transf_3; pfam02515
258594009842	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
258594009843	5 probable transmembrane helices predicted byTMHMM2.0
258594009844	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
258594009845	2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291
258594009846	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
258594009847	NADP binding site [chemical binding]; other site
258594009848	dimer interface [polypeptide binding]; other site
258594009849	enolase; Provisional; Region: eno; PRK00077
258594009850	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
258594009851	dimer interface [polypeptide binding]; other site
258594009852	metal binding site [ion binding]; metal-binding site
258594009853	substrate binding pocket [chemical binding]; other site
258594009854	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
258594009855	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
258594009856	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
258594009857	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
258594009858	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
258594009859	Ligand binding site; other site
258594009860	DXD motif; other site
258594009861	6 probable transmembrane helices predicted byTMHMM2.0
258594009862	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594009863	putative substrate translocation pore; other site
258594009864	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
258594009865	12 probable transmembrane helices predicted byTMHMM2.0
258594009866	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
258594009867	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
258594009868	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
258594009869	NIPSNAP; Region: NIPSNAP; pfam07978
258594009870	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
258594009871	PAAR motif; Region: PAAR_motif; pfam05488
258594009872	1 probable transmembrane helix predicted byTMHMM2.0
258594009873	CTP synthetase; Validated; Region: pyrG; PRK05380
258594009874	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
258594009875	Catalytic site [active]
258594009876	active site
258594009877	UTP binding site [chemical binding]; other site
258594009878	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
258594009879	active site
258594009880	putative oxyanion hole; other site
258594009881	catalytic triad [active]
258594009882	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
258594009883	2 probable transmembrane helices predicted byTMHMM2.0
258594009884	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
258594009885	triosephosphate isomerase; Provisional; Region: PRK14565
258594009886	substrate binding site [chemical binding]; other site
258594009887	dimer interface [polypeptide binding]; other site
258594009888	catalytic triad [active]
258594009889	periplasmic folding chaperone; Provisional; Region: PRK10788
258594009890	SurA N-terminal domain; Region: SurA_N_3; cl07813
258594009891	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
258594009892	1 probable transmembrane helix predicted byTMHMM2.0
258594009893	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
258594009894	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
258594009895	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
258594009896	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
258594009897	active site
258594009898	ribulose/triose binding site [chemical binding]; other site
258594009899	phosphate binding site [ion binding]; other site
258594009900	substrate (anthranilate) binding pocket [chemical binding]; other site
258594009901	product (indole) binding pocket [chemical binding]; other site
258594009902	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
258594009903	trimer interface [polypeptide binding]; other site
258594009904	dimer interface [polypeptide binding]; other site
258594009905	putative active site [active]
258594009906	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
258594009907	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
258594009908	Soluble P-type ATPase [General function prediction only]; Region: COG4087
258594009909	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
258594009910	9 probable transmembrane helices predicted byTMHMM2.0
258594009911	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
258594009912	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
258594009913	putative dimer interface [polypeptide binding]; other site
258594009914	PilZ domain; Region: PilZ; pfam07238
258594009915	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
258594009916	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
258594009917	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
258594009918	ligand binding site [chemical binding]; other site
258594009919	1 probable transmembrane helix predicted byTMHMM2.0
258594009920	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
258594009921	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594009922	motif II; other site
258594009923	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
258594009924	active site
258594009925	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
258594009926	1 probable transmembrane helix predicted byTMHMM2.0
258594009927	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
258594009928	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
258594009929	dimer interface [polypeptide binding]; other site
258594009930	putative functional site; other site
258594009931	putative MPT binding site; other site
258594009932	LexA repressor; Validated; Region: PRK00215
258594009933	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
258594009934	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
258594009935	Catalytic site [active]
258594009936	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
258594009937	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
258594009938	Competence protein; Region: Competence; pfam03772
258594009939	11 probable transmembrane helices predicted byTMHMM2.0
258594009940	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
258594009941	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
258594009942	active site
258594009943	HIGH motif; other site
258594009944	nucleotide binding site [chemical binding]; other site
258594009945	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
258594009946	KMSKS motif; other site
258594009947	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
258594009948	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
258594009949	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
258594009950	HIGH motif; other site
258594009951	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
258594009952	active site
258594009953	KMSKS motif; other site
258594009954	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
258594009955	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
258594009956	dimer interface [polypeptide binding]; other site
258594009957	active site
258594009958	citrylCoA binding site [chemical binding]; other site
258594009959	NADH binding [chemical binding]; other site
258594009960	cationic pore residues; other site
258594009961	oxalacetate/citrate binding site [chemical binding]; other site
258594009962	coenzyme A binding site [chemical binding]; other site
258594009963	catalytic triad [active]
258594009964	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
258594009965	nucleoside/Zn binding site; other site
258594009966	dimer interface [polypeptide binding]; other site
258594009967	catalytic motif [active]
258594009968	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
258594009969	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
258594009970	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
258594009971	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
258594009972	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
258594009973	active site
258594009974	1 probable transmembrane helix predicted byTMHMM2.0
258594009975	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
258594009976	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
258594009977	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
258594009978	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
258594009979	trimer interface [polypeptide binding]; other site
258594009980	active site
258594009981	UDP-GlcNAc binding site [chemical binding]; other site
258594009982	lipid binding site [chemical binding]; lipid-binding site
258594009983	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
258594009984	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
258594009985	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
258594009986	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
258594009987	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
258594009988	Surface antigen; Region: Bac_surface_Ag; pfam01103
258594009989	1 probable transmembrane helix predicted byTMHMM2.0
258594009990	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
258594009991	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
258594009992	active site
258594009993	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
258594009994	protein binding site [polypeptide binding]; other site
258594009995	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
258594009996	putative substrate binding region [chemical binding]; other site
258594009997	5 probable transmembrane helices predicted byTMHMM2.0
258594009998	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
258594009999	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
258594010000	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
258594010001	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
258594010002	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
258594010003	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
258594010004	8 probable transmembrane helices predicted byTMHMM2.0
258594010005	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
258594010006	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
258594010007	catalytic residue [active]
258594010008	putative FPP diphosphate  binding site; other site
258594010009	putative FPP binding hydrophobic cleft; other site
258594010010	dimer interface [polypeptide binding]; other site
258594010011	putative IPP diphosphate binding site; other site
258594010012	ribosome recycling factor; Reviewed; Region: frr; PRK00083
258594010013	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
258594010014	hinge region; other site
258594010015	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
258594010016	putative nucleotide binding site [chemical binding]; other site
258594010017	uridine monophosphate binding site [chemical binding]; other site
258594010018	homohexameric interface [polypeptide binding]; other site
258594010019	elongation factor Ts; Provisional; Region: tsf; PRK09377
258594010020	UBA/TS-N domain; Region: UBA; pfam00627
258594010021	Elongation factor TS; Region: EF_TS; pfam00889
258594010022	Elongation factor TS; Region: EF_TS; pfam00889
258594010023	30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311
258594010024	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
258594010025	rRNA interaction site [nucleotide binding]; other site
258594010026	S8 interaction site; other site
258594010027	putative laminin-1 binding site; other site
258594010028	Uncharacterized conserved protein [Function unknown]; Region: COG3743
258594010029	Caspase domain; Region: Peptidase_C14; pfam00656
258594010030	1 probable transmembrane helix predicted byTMHMM2.0
258594010031	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
258594010032	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
258594010033	putative active site [active]
258594010034	putative PHP Thumb interface [polypeptide binding]; other site
258594010035	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
258594010036	generic binding surface I; other site
258594010037	generic binding surface II; other site
258594010038	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
258594010039	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
258594010040	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
258594010041	Walker A/P-loop; other site
258594010042	ATP binding site [chemical binding]; other site
258594010043	Q-loop/lid; other site
258594010044	ABC transporter signature motif; other site
258594010045	Walker B; other site
258594010046	D-loop; other site
258594010047	H-loop/switch region; other site
258594010048	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
258594010049	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
258594010050	FtsX-like permease family; Region: FtsX; pfam02687
258594010051	4 probable transmembrane helices predicted byTMHMM2.0
258594010052	prolyl-tRNA synthetase; Provisional; Region: PRK12325
258594010053	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
258594010054	dimer interface [polypeptide binding]; other site
258594010055	motif 1; other site
258594010056	active site
258594010057	motif 2; other site
258594010058	motif 3; other site
258594010059	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
258594010060	anticodon binding site; other site
258594010061	CopC domain; Region: CopC; pfam04234
258594010062	Copper resistance protein D; Region: CopD; cl00563
258594010063	9 probable transmembrane helices predicted byTMHMM2.0
258594010064	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
258594010065	Protein of unknown function (DUF461); Region: DUF461; pfam04314
258594010066	1 probable transmembrane helix predicted byTMHMM2.0
258594010067	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
258594010068	2 probable transmembrane helices predicted byTMHMM2.0
258594010069	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
258594010070	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
258594010071	dimer interface [polypeptide binding]; other site
258594010072	substrate binding site [chemical binding]; other site
258594010073	metal binding site [ion binding]; metal-binding site
258594010074	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
258594010075	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
258594010076	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
258594010077	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
258594010078	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
258594010079	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
258594010080	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
258594010081	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
258594010082	13 probable transmembrane helices predicted byTMHMM2.0
258594010083	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
258594010084	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
258594010085	14 probable transmembrane helices predicted byTMHMM2.0
258594010086	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
258594010087	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
258594010088	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
258594010089	16 probable transmembrane helices predicted byTMHMM2.0
258594010090	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
258594010091	3 probable transmembrane helices predicted byTMHMM2.0
258594010092	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
258594010093	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
258594010094	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
258594010095	5 probable transmembrane helices predicted byTMHMM2.0
258594010096	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
258594010097	4Fe-4S binding domain; Region: Fer4; pfam00037
258594010098	4Fe-4S binding domain; Region: Fer4; pfam00037
258594010099	1 probable transmembrane helix predicted byTMHMM2.0
258594010100	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
258594010101	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
258594010102	8 probable transmembrane helices predicted byTMHMM2.0
258594010103	NADH dehydrogenase subunit G; Validated; Region: PRK09130
258594010104	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
258594010105	catalytic loop [active]
258594010106	iron binding site [ion binding]; other site
258594010107	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
258594010108	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
258594010109	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
258594010110	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
258594010111	SLBB domain; Region: SLBB; pfam10531
258594010112	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
258594010113	2 probable transmembrane helices predicted byTMHMM2.0
258594010114	NADH dehydrogenase subunit E; Validated; Region: PRK07539
258594010115	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
258594010116	putative dimer interface [polypeptide binding]; other site
258594010117	[2Fe-2S] cluster binding site [ion binding]; other site
258594010118	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
258594010119	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
258594010120	NADH dehydrogenase subunit D; Validated; Region: PRK06075
258594010121	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
258594010122	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
258594010123	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
258594010124	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
258594010125	3 probable transmembrane helices predicted byTMHMM2.0
258594010126	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
258594010127	IHF - DNA interface [nucleotide binding]; other site
258594010128	IHF dimer interface [polypeptide binding]; other site
258594010129	peptidase T; Region: peptidase-T; TIGR01882
258594010130	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
258594010131	metal binding site [ion binding]; metal-binding site
258594010132	dimer interface [polypeptide binding]; other site
258594010133	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594010134	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594010135	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
258594010136	12 probable transmembrane helices predicted byTMHMM2.0
258594010137	PAS fold; Region: PAS_7; pfam12860
258594010138	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594010139	metal binding site [ion binding]; metal-binding site
258594010140	active site
258594010141	I-site; other site
258594010142	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594010143	1 probable transmembrane helix predicted byTMHMM2.0
258594010144	Virulence protein [General function prediction only]; Region: COG3943
258594010145	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
258594010146	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
258594010147	Found in ATP-dependent protease La (LON); Region: LON; smart00464
258594010148	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594010149	Walker A motif; other site
258594010150	ATP binding site [chemical binding]; other site
258594010151	Walker B motif; other site
258594010152	arginine finger; other site
258594010153	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
258594010154	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
258594010155	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
258594010156	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594010157	Walker A motif; other site
258594010158	ATP binding site [chemical binding]; other site
258594010159	Walker B motif; other site
258594010160	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
258594010161	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
258594010162	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
258594010163	oligomer interface [polypeptide binding]; other site
258594010164	active site residues [active]
258594010165	trigger factor; Provisional; Region: tig; PRK01490
258594010166	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
258594010167	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
258594010168	Transcriptional regulators [Transcription]; Region: MarR; COG1846
258594010169	MarR family; Region: MarR_2; pfam12802
258594010170	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
258594010171	Multicopper oxidase; Region: Cu-oxidase; pfam00394
258594010172	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
258594010173	Uncharacterized conserved protein [Function unknown]; Region: COG0062
258594010174	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
258594010175	putative substrate binding site [chemical binding]; other site
258594010176	putative ATP binding site [chemical binding]; other site
258594010177	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
258594010178	Nitrogen regulatory protein P-II; Region: P-II; smart00938
258594010179	glutamine synthetase; Provisional; Region: glnA; PRK09469
258594010180	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
258594010181	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
258594010182	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594010183	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594010184	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
258594010185	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
258594010186	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
258594010187	inhibitor-cofactor binding pocket; inhibition site
258594010188	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594010189	catalytic residue [active]
258594010190	AAA domain; Region: AAA_26; pfam13500
258594010191	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
258594010192	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
258594010193	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
258594010194	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594010195	catalytic residue [active]
258594010196	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
258594010197	Amidase; Region: Amidase; cl11426
258594010198	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
258594010199	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
258594010200	ligand binding site [chemical binding]; other site
258594010201	NAD binding site [chemical binding]; other site
258594010202	dimerization interface [polypeptide binding]; other site
258594010203	catalytic site [active]
258594010204	EamA-like transporter family; Region: EamA; pfam00892
258594010205	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
258594010206	EamA-like transporter family; Region: EamA; pfam00892
258594010207	10 probable transmembrane helices predicted byTMHMM2.0
258594010208	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
258594010209	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
258594010210	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
258594010211	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
258594010212	active site
258594010213	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
258594010214	TSCPD domain; Region: TSCPD; pfam12637
258594010215	PV-1 protein (PLVAP); Region: PV-1; pfam06637
258594010216	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
258594010217	ISR1-like IS element
258594010218	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
258594010219	Integrase core domain; Region: rve; pfam00665
258594010220	Integrase core domain; Region: rve_3; pfam13683
258594010221	HTH-like domain; Region: HTH_21; pfam13276
258594010222	Transposase; Region: HTH_Tnp_1; pfam01527
258594010223	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594010224	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594010225	metal binding site [ion binding]; metal-binding site
258594010226	active site
258594010227	I-site; other site
258594010228	7 probable transmembrane helices predicted byTMHMM2.0
258594010229	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
258594010230	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
258594010231	NAD binding site [chemical binding]; other site
258594010232	active site
258594010233	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
258594010234	putative substrate binding pocket [chemical binding]; other site
258594010235	trimer interface [polypeptide binding]; other site
258594010236	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
258594010237	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
258594010238	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
258594010239	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
258594010240	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
258594010241	NAD(P) binding site [chemical binding]; other site
258594010242	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
258594010243	1 probable transmembrane helix predicted byTMHMM2.0
258594010244	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
258594010245	UPF0126 domain; Region: UPF0126; pfam03458
258594010246	Predicted membrane protein [Function unknown]; Region: COG2860
258594010247	UPF0126 domain; Region: UPF0126; pfam03458
258594010248	7 probable transmembrane helices predicted byTMHMM2.0
258594010249	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594010250	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594010251	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
258594010252	dimerization interface [polypeptide binding]; other site
258594010253	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
258594010254	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
258594010255	12 probable transmembrane helices predicted byTMHMM2.0
258594010256	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
258594010257	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
258594010258	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
258594010259	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
258594010260	dimer interface [polypeptide binding]; other site
258594010261	active site
258594010262	catalytic residue [active]
258594010263	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
258594010264	active site
258594010265	phosphorylation site [posttranslational modification]
258594010266	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
258594010267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594010268	active site
258594010269	phosphorylation site [posttranslational modification]
258594010270	intermolecular recognition site; other site
258594010271	dimerization interface [polypeptide binding]; other site
258594010272	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
258594010273	DNA binding site [nucleotide binding]
258594010274	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
258594010275	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
258594010276	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
258594010277	Ligand Binding Site [chemical binding]; other site
258594010278	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
258594010279	GAF domain; Region: GAF_3; pfam13492
258594010280	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594010281	dimer interface [polypeptide binding]; other site
258594010282	phosphorylation site [posttranslational modification]
258594010283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594010284	ATP binding site [chemical binding]; other site
258594010285	Mg2+ binding site [ion binding]; other site
258594010286	G-X-G motif; other site
258594010287	4 probable transmembrane helices predicted byTMHMM2.0
258594010288	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
258594010289	1 probable transmembrane helix predicted byTMHMM2.0
258594010290	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
258594010291	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
258594010292	Soluble P-type ATPase [General function prediction only]; Region: COG4087
258594010293	7 probable transmembrane helices predicted byTMHMM2.0
258594010294	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
258594010295	12 probable transmembrane helices predicted byTMHMM2.0
258594010296	1 probable transmembrane helix predicted byTMHMM2.0
258594010297	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
258594010298	12 probable transmembrane helices predicted byTMHMM2.0
258594010299	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
258594010300	1 probable transmembrane helix predicted byTMHMM2.0
258594010302	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
258594010303	1 probable transmembrane helix predicted byTMHMM2.0
258594010304	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
258594010305	1 probable transmembrane helix predicted byTMHMM2.0
258594010306	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
258594010307	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594010308	active site
258594010309	phosphorylation site [posttranslational modification]
258594010310	intermolecular recognition site; other site
258594010311	dimerization interface [polypeptide binding]; other site
258594010312	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
258594010313	DNA binding residues [nucleotide binding]
258594010314	dimerization interface [polypeptide binding]; other site
258594010315	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
258594010316	GAF domain; Region: GAF; pfam01590
258594010317	Phytochrome region; Region: PHY; pfam00360
258594010318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594010319	dimer interface [polypeptide binding]; other site
258594010320	phosphorylation site [posttranslational modification]
258594010321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594010322	ATP binding site [chemical binding]; other site
258594010323	Mg2+ binding site [ion binding]; other site
258594010324	G-X-G motif; other site
258594010325	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
258594010326	GAF domain; Region: GAF; pfam01590
258594010327	Phytochrome region; Region: PHY; pfam00360
258594010328	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594010329	dimer interface [polypeptide binding]; other site
258594010330	phosphorylation site [posttranslational modification]
258594010331	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594010332	ATP binding site [chemical binding]; other site
258594010333	Mg2+ binding site [ion binding]; other site
258594010334	G-X-G motif; other site
258594010335	Response regulator receiver domain; Region: Response_reg; pfam00072
258594010336	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594010337	active site
258594010338	phosphorylation site [posttranslational modification]
258594010339	intermolecular recognition site; other site
258594010340	dimerization interface [polypeptide binding]; other site
258594010341	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594010342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594010343	active site
258594010344	phosphorylation site [posttranslational modification]
258594010345	intermolecular recognition site; other site
258594010346	dimerization interface [polypeptide binding]; other site
258594010347	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
258594010348	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
258594010349	Histidine kinase; Region: HisKA_3; pfam07730
258594010350	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594010351	ATP binding site [chemical binding]; other site
258594010352	Mg2+ binding site [ion binding]; other site
258594010353	G-X-G motif; other site
258594010354	pseudogene of RND multidrug efflux transporter MexF; AcrB/AcrD/AcrF family
258594010355	1 probable transmembrane helix predicted byTMHMM2.0
258594010356	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594010357	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594010358	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594010359	1 probable transmembrane helix predicted byTMHMM2.0
258594010360	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594010361	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594010362	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594010363	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594010364	metal binding site [ion binding]; metal-binding site
258594010365	active site
258594010366	I-site; other site
258594010367	5 probable transmembrane helices predicted byTMHMM2.0
258594010368	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
258594010369	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
258594010370	active site
258594010371	catalytic tetrad [active]
258594010372	CAAX protease self-immunity; Region: Abi; pfam02517
258594010373	6 probable transmembrane helices predicted byTMHMM2.0
258594010374	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
258594010375	potassium uptake protein; Region: kup; TIGR00794
258594010376	12 probable transmembrane helices predicted byTMHMM2.0
258594010377	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
258594010378	Sel1-like repeats; Region: SEL1; smart00671
258594010379	Sel1-like repeats; Region: SEL1; smart00671
258594010380	1 probable transmembrane helix predicted byTMHMM2.0
258594010381	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
258594010382	2 probable transmembrane helices predicted byTMHMM2.0
258594010383	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594010384	Coenzyme A binding pocket [chemical binding]; other site
258594010385	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
258594010386	CoenzymeA binding site [chemical binding]; other site
258594010387	subunit interaction site [polypeptide binding]; other site
258594010388	PHB binding site; other site
258594010389	acetylornithine deacetylase; Provisional; Region: PRK06837
258594010390	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
258594010391	metal binding site [ion binding]; metal-binding site
258594010392	dimer interface [polypeptide binding]; other site
258594010393	1 probable transmembrane helix predicted byTMHMM2.0
258594010394	1 probable transmembrane helix predicted byTMHMM2.0
258594010395	CreA protein; Region: CreA; pfam05981
258594010396	1 probable transmembrane helix predicted byTMHMM2.0
258594010397	hypothetical protein; Provisional; Region: PRK06132
258594010398	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
258594010399	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
258594010400	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
258594010401	NodB motif; other site
258594010402	active site
258594010403	catalytic site [active]
258594010404	metal binding site [ion binding]; metal-binding site
258594010405	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
258594010406	NADP+ binding site [chemical binding]; other site
258594010407	folate binding site [chemical binding]; other site
258594010408	Predicted membrane protein [Function unknown]; Region: COG2259
258594010409	4 probable transmembrane helices predicted byTMHMM2.0
258594010410	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
258594010411	Malic enzyme, N-terminal domain; Region: malic; pfam00390
258594010412	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
258594010413	putative NAD(P) binding site [chemical binding]; other site
258594010414	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
258594010415	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
258594010416	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
258594010417	dimer interface [polypeptide binding]; other site
258594010418	anticodon binding site; other site
258594010419	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
258594010420	homodimer interface [polypeptide binding]; other site
258594010421	motif 1; other site
258594010422	active site
258594010423	motif 2; other site
258594010424	GAD domain; Region: GAD; pfam02938
258594010425	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
258594010426	active site
258594010427	motif 3; other site
258594010428	hypothetical protein; Validated; Region: PRK00029
258594010429	Uncharacterized conserved protein [Function unknown]; Region: COG0397
258594010430	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
258594010431	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
258594010432	catalytic site [active]
258594010433	putative active site [active]
258594010434	putative substrate binding site [chemical binding]; other site
258594010435	HRDC domain; Region: HRDC; pfam00570
258594010436	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
258594010437	3 probable transmembrane helices predicted byTMHMM2.0
258594010438	exopolyphosphatase; Region: exo_poly_only; TIGR03706
258594010439	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
258594010440	polyphosphate kinase; Provisional; Region: PRK05443
258594010441	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
258594010442	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
258594010443	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
258594010444	putative domain interface [polypeptide binding]; other site
258594010445	putative active site [active]
258594010446	catalytic site [active]
258594010447	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
258594010448	putative domain interface [polypeptide binding]; other site
258594010449	putative active site [active]
258594010450	catalytic site [active]
258594010451	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
258594010452	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
258594010453	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
258594010454	4 probable transmembrane helices predicted byTMHMM2.0
258594010455	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
258594010456	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
258594010457	dimerization interface [polypeptide binding]; other site
258594010458	putative ATP binding site [chemical binding]; other site
258594010459	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
258594010460	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
258594010461	active site
258594010462	substrate binding site [chemical binding]; other site
258594010463	cosubstrate binding site; other site
258594010464	catalytic site [active]
258594010465	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
258594010466	DNA-binding site [nucleotide binding]; DNA binding site
258594010467	RNA-binding motif; other site
258594010468	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594010469	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594010470	ligand binding site [chemical binding]; other site
258594010471	flexible hinge region; other site
258594010472	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
258594010473	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
258594010474	5 probable transmembrane helices predicted byTMHMM2.0
258594010475	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
258594010476	active site
258594010477	multimer interface [polypeptide binding]; other site
258594010478	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
258594010479	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
258594010480	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
258594010481	ABC transporter; Region: ABC_tran_2; pfam12848
258594010482	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
258594010483	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
258594010484	DNA polymerase III subunit chi; Validated; Region: PRK05728
258594010485	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
258594010486	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
258594010487	interface (dimer of trimers) [polypeptide binding]; other site
258594010488	Substrate-binding/catalytic site; other site
258594010489	Zn-binding sites [ion binding]; other site
258594010490	Predicted permeases [General function prediction only]; Region: COG0795
258594010491	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
258594010492	6 probable transmembrane helices predicted byTMHMM2.0
258594010493	Predicted permeases [General function prediction only]; Region: COG0795
258594010494	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
258594010495	5 probable transmembrane helices predicted byTMHMM2.0
258594010496	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
258594010497	Organic solvent tolerance protein; Region: OstA_C; pfam04453
258594010498	1 probable transmembrane helix predicted byTMHMM2.0
258594010499	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
258594010500	SurA N-terminal domain; Region: SurA_N; pfam09312
258594010501	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
258594010502	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
258594010503	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
258594010504	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594010505	S-adenosylmethionine binding site [chemical binding]; other site
258594010506	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
258594010507	6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240
258594010508	putative NAD(P) binding site [chemical binding]; other site
258594010509	catalytic Zn binding site [ion binding]; other site
258594010510	1 probable transmembrane helix predicted byTMHMM2.0
258594010511	1 probable transmembrane helix predicted byTMHMM2.0
258594010512	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
258594010513	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
258594010514	catalytic site [active]
258594010515	G-X2-G-X-G-K; other site
258594010516	hypothetical protein; Provisional; Region: PRK11820
258594010517	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
258594010518	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
258594010519	YceG-like family; Region: YceG; pfam02618
258594010520	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
258594010521	dimerization interface [polypeptide binding]; other site
258594010522	1 probable transmembrane helix predicted byTMHMM2.0
258594010523	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
258594010524	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
258594010525	dimer interface [polypeptide binding]; other site
258594010526	active site
258594010527	acyl carrier protein; Provisional; Region: acpP; PRK00982
258594010528	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
258594010529	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594010530	NAD(P) binding site [chemical binding]; other site
258594010531	active site
258594010532	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
258594010533	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
258594010534	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594010535	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594010536	metal binding site [ion binding]; metal-binding site
258594010537	active site
258594010538	I-site; other site
258594010539	6 probable transmembrane helices predicted byTMHMM2.0
258594010540	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
258594010541	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
258594010542	8 probable transmembrane helices predicted byTMHMM2.0
258594010543	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
258594010544	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
258594010545	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
258594010546	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
258594010547	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594010548	S-adenosylmethionine binding site [chemical binding]; other site
258594010549	replicative DNA helicase; Provisional; Region: PRK09165
258594010550	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
258594010551	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
258594010552	Walker A motif; other site
258594010553	ATP binding site [chemical binding]; other site
258594010554	Walker B motif; other site
258594010555	DNA binding loops [nucleotide binding]
258594010556	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
258594010557	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
258594010558	active site
258594010559	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
258594010560	dimer interface [polypeptide binding]; other site
258594010561	substrate binding site [chemical binding]; other site
258594010562	catalytic residues [active]
258594010563	2 probable transmembrane helices predicted byTMHMM2.0
258594010564	9 probable transmembrane helices predicted byTMHMM2.0
258594010565	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
258594010566	DNA repair protein RadA; Provisional; Region: PRK11823
258594010567	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
258594010568	Walker A motif; other site
258594010569	ATP binding site [chemical binding]; other site
258594010570	Walker B motif; other site
258594010571	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
258594010572	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
258594010573	Colicin V production protein; Region: Colicin_V; pfam02674
258594010574	4 probable transmembrane helices predicted byTMHMM2.0
258594010575	amidophosphoribosyltransferase; Provisional; Region: PRK09123
258594010576	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
258594010577	active site
258594010578	tetramer interface [polypeptide binding]; other site
258594010579	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
258594010580	active site
258594010581	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594010582	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
258594010583	NAD(P) binding site [chemical binding]; other site
258594010584	active site
258594010585	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594010586	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
258594010587	putative ligand binding site [chemical binding]; other site
258594010588	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594010589	Major Facilitator Superfamily; Region: MFS_1; pfam07690
258594010590	putative substrate translocation pore; other site
258594010591	12 probable transmembrane helices predicted byTMHMM2.0
258594010592	GTP-binding protein Der; Reviewed; Region: PRK00093
258594010593	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
258594010594	G1 box; other site
258594010595	GTP/Mg2+ binding site [chemical binding]; other site
258594010596	Switch I region; other site
258594010597	G2 box; other site
258594010598	Switch II region; other site
258594010599	G3 box; other site
258594010600	G4 box; other site
258594010601	G5 box; other site
258594010602	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
258594010603	G1 box; other site
258594010604	GTP/Mg2+ binding site [chemical binding]; other site
258594010605	Switch I region; other site
258594010606	G2 box; other site
258594010607	G3 box; other site
258594010608	Switch II region; other site
258594010609	G4 box; other site
258594010610	G5 box; other site
258594010611	1 probable transmembrane helix predicted byTMHMM2.0
258594010612	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
258594010613	Uncharacterized protein family (UPF0253); Region: UPF0253; cl11640
258594010614	1 probable transmembrane helix predicted byTMHMM2.0
258594010615	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
258594010616	oligomerization interface [polypeptide binding]; other site
258594010617	active site
258594010618	metal binding site [ion binding]; metal-binding site
258594010619	NnrU protein; Region: NnrU; pfam07298
258594010620	5 probable transmembrane helices predicted byTMHMM2.0
258594010621	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
258594010622	Cache domain; Region: Cache_2; cl07034
258594010623	1 probable transmembrane helix predicted byTMHMM2.0
258594010624	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
258594010625	Sel1-like repeats; Region: SEL1; smart00671
258594010626	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
258594010627	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
258594010628	GatB domain; Region: GatB_Yqey; smart00845
258594010629	PAS domain; Region: PAS_8; pfam13188
258594010630	PAS domain; Region: PAS_9; pfam13426
258594010631	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
258594010632	Histidine kinase; Region: HisKA_2; pfam07568
258594010633	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594010634	ATP binding site [chemical binding]; other site
258594010635	Mg2+ binding site [ion binding]; other site
258594010636	G-X-G motif; other site
258594010637	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
258594010638	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
258594010639	Protein of unknown function (DUF497); Region: DUF497; pfam04365
258594010640	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
258594010641	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
258594010642	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
258594010643	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
258594010644	FMN binding site [chemical binding]; other site
258594010645	substrate binding site [chemical binding]; other site
258594010646	putative catalytic residue [active]
258594010647	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
258594010648	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
258594010649	SEC-C motif; Region: SEC-C; pfam02810
258594010650	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594010651	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594010652	active site
258594010653	indolepyruvate/phenylpyruvate decarboxylase, Azospirillum family; Region: indol_phenyl_DC; TIGR03394
258594010654	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
258594010655	dimer interface [polypeptide binding]; other site
258594010656	PYR/PP interface [polypeptide binding]; other site
258594010657	TPP binding site [chemical binding]; other site
258594010658	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
258594010659	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
258594010660	TPP-binding site [chemical binding]; other site
258594010661	dimer interface [polypeptide binding]; other site
258594010662	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
258594010663	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
258594010664	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
258594010665	dihydroorotase; Validated; Region: PRK09059
258594010666	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
258594010667	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
258594010668	active site
258594010669	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
258594010670	5 probable transmembrane helices predicted byTMHMM2.0
258594010671	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
258594010672	DNA protecting protein DprA; Region: dprA; TIGR00732
258594010673	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
258594010674	11 probable transmembrane helices predicted byTMHMM2.0
258594010675	1 probable transmembrane helix predicted byTMHMM2.0
258594010676	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
258594010677	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
258594010678	active site
258594010679	interdomain interaction site; other site
258594010680	putative metal-binding site [ion binding]; other site
258594010681	nucleotide binding site [chemical binding]; other site
258594010682	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
258594010683	domain I; other site
258594010684	DNA binding groove [nucleotide binding]
258594010685	phosphate binding site [ion binding]; other site
258594010686	domain II; other site
258594010687	domain III; other site
258594010688	nucleotide binding site [chemical binding]; other site
258594010689	catalytic site [active]
258594010690	domain IV; other site
258594010691	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
258594010692	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
258594010693	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
258594010694	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
258594010695	ribonuclease R; Region: RNase_R; TIGR02063
258594010696	RNB domain; Region: RNB; pfam00773
258594010697	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
258594010698	RNA binding site [nucleotide binding]; other site
258594010699	hypothetical protein; Provisional; Region: PRK05978
258594010700	2 probable transmembrane helices predicted byTMHMM2.0
258594010701	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
258594010702	12 probable transmembrane helices predicted byTMHMM2.0
258594010703	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
258594010704	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594010705	non-specific DNA binding site [nucleotide binding]; other site
258594010706	salt bridge; other site
258594010707	sequence-specific DNA binding site [nucleotide binding]; other site
258594010708	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
258594010709	response regulator PleD; Reviewed; Region: pleD; PRK09581
258594010710	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594010711	active site
258594010712	phosphorylation site [posttranslational modification]
258594010713	intermolecular recognition site; other site
258594010714	dimerization interface [polypeptide binding]; other site
258594010715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594010716	active site
258594010717	phosphorylation site [posttranslational modification]
258594010718	intermolecular recognition site; other site
258594010719	dimerization interface [polypeptide binding]; other site
258594010720	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594010721	metal binding site [ion binding]; metal-binding site
258594010722	active site
258594010723	I-site; other site
258594010724	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594010725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594010726	active site
258594010727	phosphorylation site [posttranslational modification]
258594010728	intermolecular recognition site; other site
258594010729	dimerization interface [polypeptide binding]; other site
258594010730	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
258594010731	DNA polymerase IV; Provisional; Region: PRK02794
258594010732	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
258594010733	active site
258594010734	DNA binding site [nucleotide binding]
258594010735	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
258594010736	1 probable transmembrane helix predicted byTMHMM2.0
258594010737	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
258594010738	homotrimer interaction site [polypeptide binding]; other site
258594010739	putative active site [active]
258594010740	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
258594010741	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
258594010742	putative active site [active]
258594010743	catalytic site [active]
258594010744	putative metal binding site [ion binding]; other site
258594010745	Protein of unknown function, DUF482; Region: DUF482; pfam04339
258594010746	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
258594010747	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
258594010748	HIT family signature motif; other site
258594010749	catalytic residue [active]
258594010750	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
258594010751	homodimer interaction site [polypeptide binding]; other site
258594010752	cofactor binding site; other site
258594010753	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
258594010754	4 probable transmembrane helices predicted byTMHMM2.0
258594010755	AzlC protein; Region: AzlC; pfam03591
258594010756	7 probable transmembrane helices predicted byTMHMM2.0
258594010757	PilZ domain; Region: PilZ; pfam07238
258594010758	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
258594010759	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
258594010760	N-acetyl-D-glucosamine binding site [chemical binding]; other site
258594010761	catalytic residue [active]
258594010762	Sporulation related domain; Region: SPOR; pfam05036
258594010763	9 probable transmembrane helices predicted byTMHMM2.0
258594010764	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
258594010765	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594010766	Walker A motif; other site
258594010767	ATP binding site [chemical binding]; other site
258594010768	Walker B motif; other site
258594010769	arginine finger; other site
258594010770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594010771	Walker A motif; other site
258594010772	ATP binding site [chemical binding]; other site
258594010773	Walker B motif; other site
258594010774	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
258594010775	Uncharacterized conserved protein [Function unknown]; Region: COG2127
258594010776	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
258594010777	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
258594010778	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
258594010779	1 probable transmembrane helix predicted byTMHMM2.0
258594010780	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
258594010781	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
258594010782	Sporulation related domain; Region: SPOR; pfam05036
258594010783	1 probable transmembrane helix predicted byTMHMM2.0
258594010784	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
258594010785	HSP70 interaction site [polypeptide binding]; other site
258594010786	2 probable transmembrane helices predicted byTMHMM2.0
258594010787	von Willebrand factor type A domain; Region: VWA_2; pfam13519
258594010788	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
258594010789	1 probable transmembrane helix predicted byTMHMM2.0
258594010790	ATPase MipZ; Region: MipZ; pfam09140
258594010791	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
258594010792	P-loop; other site
258594010793	Magnesium ion binding site [ion binding]; other site
258594010794	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
258594010795	Magnesium ion binding site [ion binding]; other site
258594010796	pantoate--beta-alanine ligase; Region: panC; TIGR00018
258594010797	Pantoate-beta-alanine ligase; Region: PanC; cd00560
258594010798	active site
258594010799	ATP-binding site [chemical binding]; other site
258594010800	pantoate-binding site; other site
258594010801	HXXH motif; other site
258594010802	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
258594010803	2 probable transmembrane helices predicted byTMHMM2.0
258594010804	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
258594010805	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
258594010806	putative C-terminal domain interface [polypeptide binding]; other site
258594010807	putative GSH binding site (G-site) [chemical binding]; other site
258594010808	putative dimer interface [polypeptide binding]; other site
258594010809	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
258594010810	putative substrate binding pocket (H-site) [chemical binding]; other site
258594010811	putative N-terminal domain interface [polypeptide binding]; other site
258594010812	Uncharacterized conserved protein [Function unknown]; Region: COG1434
258594010813	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
258594010814	putative active site [active]
258594010815	2 probable transmembrane helices predicted byTMHMM2.0
258594010816	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
258594010817	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
258594010818	active site
258594010819	catalytic tetrad [active]
258594010820	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594010821	non-specific DNA binding site [nucleotide binding]; other site
258594010822	salt bridge; other site
258594010823	sequence-specific DNA binding site [nucleotide binding]; other site
258594010824	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
258594010825	MgtE intracellular N domain; Region: MgtE_N; smart00924
258594010826	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
258594010827	Divalent cation transporter; Region: MgtE; cl00786
258594010828	4 probable transmembrane helices predicted byTMHMM2.0
258594010829	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
258594010830	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
258594010831	NodB motif; other site
258594010832	active site
258594010833	catalytic site [active]
258594010834	metal binding site [ion binding]; metal-binding site
258594010835	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
258594010836	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
258594010837	NodB motif; other site
258594010838	active site
258594010839	catalytic site [active]
258594010840	metal binding site [ion binding]; metal-binding site
258594010841	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
258594010842	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
258594010843	RES domain; Region: RES; pfam08808
258594010844	hypothetical protein; Validated; Region: PRK06033
258594010845	lipoate-protein ligase B; Provisional; Region: PRK14341
258594010846	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
258594010847	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594010848	putative active site [active]
258594010849	heme pocket [chemical binding]; other site
258594010850	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594010851	putative active site [active]
258594010852	heme pocket [chemical binding]; other site
258594010853	GAF domain; Region: GAF; cl17456
258594010854	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594010855	metal binding site [ion binding]; metal-binding site
258594010856	active site
258594010857	I-site; other site
258594010858	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594010859	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
258594010860	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594010861	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594010862	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
258594010863	dimerization interface [polypeptide binding]; other site
258594010864	1 probable transmembrane helix predicted byTMHMM2.0
258594010865	acylphosphatase; Provisional; Region: PRK14421
258594010866	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
258594010867	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
258594010868	tetramer interface [polypeptide binding]; other site
258594010869	active site
258594010870	Mg2+/Mn2+ binding site [ion binding]; other site
258594010871	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
258594010872	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
258594010873	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
258594010874	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
258594010875	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
258594010876	carboxyltransferase (CT) interaction site; other site
258594010877	biotinylation site [posttranslational modification]; other site
258594010878	Sulfatase; Region: Sulfatase; cl17466
258594010879	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
258594010880	1 probable transmembrane helix predicted byTMHMM2.0
258594010881	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
258594010882	4 probable transmembrane helices predicted byTMHMM2.0
258594010883	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
258594010884	DNA photolyase; Region: DNA_photolyase; pfam00875
258594010885	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
258594010886	EamA-like transporter family; Region: EamA; pfam00892
258594010887	10 probable transmembrane helices predicted byTMHMM2.0
258594010888	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
258594010889	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594010890	6 probable transmembrane helices predicted byTMHMM2.0
258594010891	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
258594010892	HAMP domain; Region: HAMP; pfam00672
258594010893	dimerization interface [polypeptide binding]; other site
258594010894	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594010895	dimer interface [polypeptide binding]; other site
258594010896	putative CheW interface [polypeptide binding]; other site
258594010897	2 probable transmembrane helices predicted byTMHMM2.0
258594010898	HAMP domain; Region: HAMP; pfam00672
258594010899	PAS domain S-box; Region: sensory_box; TIGR00229
258594010900	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594010901	putative active site [active]
258594010902	heme pocket [chemical binding]; other site
258594010903	PAS fold; Region: PAS_4; pfam08448
258594010904	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
258594010905	putative active site [active]
258594010906	heme pocket [chemical binding]; other site
258594010907	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594010908	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594010909	ATP binding site [chemical binding]; other site
258594010910	Mg2+ binding site [ion binding]; other site
258594010911	G-X-G motif; other site
258594010912	1 probable transmembrane helix predicted byTMHMM2.0
258594010913	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
258594010914	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
258594010915	Trp docking motif [polypeptide binding]; other site
258594010916	cytochrome domain interface [polypeptide binding]; other site
258594010917	active site
258594010918	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
258594010919	1 probable transmembrane helix predicted byTMHMM2.0
258594010920	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
258594010921	nudix motif; other site
258594010922	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
258594010923	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
258594010924	inhibitor site; inhibition site
258594010925	active site
258594010926	dimer interface [polypeptide binding]; other site
258594010927	catalytic residue [active]
258594010928	short chain dehydrogenase; Provisional; Region: PRK07791
258594010929	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
258594010930	homodimer interface [polypeptide binding]; other site
258594010931	NAD binding site [chemical binding]; other site
258594010932	active site
258594010933	enoyl-CoA hydratase; Region: PLN02864
258594010934	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
258594010935	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
258594010936	dimer interaction site [polypeptide binding]; other site
258594010937	substrate-binding tunnel; other site
258594010938	active site
258594010939	catalytic site [active]
258594010940	substrate binding site [chemical binding]; other site
258594010941	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
258594010942	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
258594010943	DUF35 OB-fold domain; Region: DUF35; pfam01796
258594010944	acetyl-CoA acetyltransferase; Provisional; Region: PRK08142
258594010945	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
258594010946	active site
258594010947	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
258594010948	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
258594010949	dimer interface [polypeptide binding]; other site
258594010950	PYR/PP interface [polypeptide binding]; other site
258594010951	TPP binding site [chemical binding]; other site
258594010952	substrate binding site [chemical binding]; other site
258594010953	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
258594010954	TPP-binding site [chemical binding]; other site
258594010955	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
258594010956	1 probable transmembrane helix predicted byTMHMM2.0
258594010957	1 probable transmembrane helix predicted byTMHMM2.0
258594010958	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
258594010959	6 probable transmembrane helices predicted byTMHMM2.0
258594010960	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
258594010961	active site
258594010962	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
258594010963	Catalytic domain of Protein Kinases; Region: PKc; cd00180
258594010964	active site
258594010965	ATP binding site [chemical binding]; other site
258594010966	substrate binding site [chemical binding]; other site
258594010967	activation loop (A-loop); other site
258594010968	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
258594010969	1 probable transmembrane helix predicted byTMHMM2.0
258594010970	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
258594010971	6 probable transmembrane helices predicted byTMHMM2.0
258594010972	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
258594010973	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
258594010974	putative NAD(P) binding site [chemical binding]; other site
258594010975	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
258594010976	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
258594010977	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
258594010978	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
258594010979	3 probable transmembrane helices predicted byTMHMM2.0
258594010980	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
258594010981	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
258594010982	ATP12 chaperone protein; Region: ATP12; cl02228
258594010983	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
258594010984	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
258594010985	RNA binding surface [nucleotide binding]; other site
258594010986	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
258594010987	active site
258594010988	2 probable transmembrane helices predicted byTMHMM2.0
258594010989	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
258594010990	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
258594010991	1 probable transmembrane helix predicted byTMHMM2.0
258594010992	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594010993	Tetratricopeptide repeat; Region: TPR_12; pfam13424
258594010994	binding surface
258594010995	TPR motif; other site
258594010996	CHAT domain; Region: CHAT; pfam12770
258594010997	1 probable transmembrane helix predicted byTMHMM2.0
258594010998	5 probable transmembrane helices predicted byTMHMM2.0
258594010999	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
258594011000	putative FMN binding site [chemical binding]; other site
258594011001	PAS domain S-box; Region: sensory_box; TIGR00229
258594011002	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594011003	PAS fold; Region: PAS_3; pfam08447
258594011004	putative active site [active]
258594011005	heme pocket [chemical binding]; other site
258594011006	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594011007	dimer interface [polypeptide binding]; other site
258594011008	phosphorylation site [posttranslational modification]
258594011009	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594011010	ATP binding site [chemical binding]; other site
258594011011	Mg2+ binding site [ion binding]; other site
258594011012	G-X-G motif; other site
258594011013	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594011014	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594011015	active site
258594011016	phosphorylation site [posttranslational modification]
258594011017	intermolecular recognition site; other site
258594011018	dimerization interface [polypeptide binding]; other site
258594011019	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
258594011020	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594011021	putative ligand binding site [chemical binding]; other site
258594011022	Uncharacterized conserved protein [Function unknown]; Region: COG0432
258594011023	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594011024	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594011025	metal binding site [ion binding]; metal-binding site
258594011026	active site
258594011027	I-site; other site
258594011028	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594011029	5 probable transmembrane helices predicted byTMHMM2.0
258594011030	recombination factor protein RarA; Reviewed; Region: PRK13342
258594011031	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594011032	Walker A motif; other site
258594011033	ATP binding site [chemical binding]; other site
258594011034	Walker B motif; other site
258594011035	arginine finger; other site
258594011036	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
258594011037	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
258594011038	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
258594011039	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
258594011040	protein binding site [polypeptide binding]; other site
258594011041	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
258594011042	protein binding site [polypeptide binding]; other site
258594011043	Predicted transcriptional regulators [Transcription]; Region: COG1733
258594011044	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594011045	dimerization interface [polypeptide binding]; other site
258594011046	putative DNA binding site [nucleotide binding]; other site
258594011047	putative Zn2+ binding site [ion binding]; other site
258594011048	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
258594011049	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
258594011050	putative NAD(P) binding site [chemical binding]; other site
258594011051	dimer interface [polypeptide binding]; other site
258594011052	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
258594011053	classical (c) SDRs; Region: SDR_c; cd05233
258594011054	NAD(P) binding site [chemical binding]; other site
258594011055	active site
258594011056	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
258594011057	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
258594011058	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
258594011059	alphaNTD - beta interaction site [polypeptide binding]; other site
258594011060	alphaNTD homodimer interface [polypeptide binding]; other site
258594011061	alphaNTD - beta' interaction site [polypeptide binding]; other site
258594011062	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
258594011063	30S ribosomal protein S11; Validated; Region: PRK05309
258594011064	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
258594011065	30S ribosomal protein S13; Region: bact_S13; TIGR03631
258594011066	adenylate kinase; Reviewed; Region: adk; PRK00279
258594011067	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
258594011068	AMP-binding site [chemical binding]; other site
258594011069	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
258594011070	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
258594011071	SecY translocase; Region: SecY; pfam00344
258594011072	10 probable transmembrane helices predicted byTMHMM2.0
258594011073	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
258594011074	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
258594011075	23S rRNA binding site [nucleotide binding]; other site
258594011076	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
258594011077	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
258594011078	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
258594011079	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
258594011080	5S rRNA interface [nucleotide binding]; other site
258594011081	23S rRNA interface [nucleotide binding]; other site
258594011082	L5 interface [polypeptide binding]; other site
258594011083	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
258594011084	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
258594011085	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
258594011086	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
258594011087	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
258594011088	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
258594011089	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
258594011090	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
258594011091	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
258594011092	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
258594011093	RNA binding site [nucleotide binding]; other site
258594011094	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
258594011095	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
258594011096	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
258594011097	23S rRNA interface [nucleotide binding]; other site
258594011098	putative translocon interaction site; other site
258594011099	signal recognition particle (SRP54) interaction site; other site
258594011100	L23 interface [polypeptide binding]; other site
258594011101	trigger factor interaction site; other site
258594011102	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
258594011103	23S rRNA interface [nucleotide binding]; other site
258594011104	5S rRNA interface [nucleotide binding]; other site
258594011105	putative antibiotic binding site [chemical binding]; other site
258594011106	L25 interface [polypeptide binding]; other site
258594011107	L27 interface [polypeptide binding]; other site
258594011108	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
258594011109	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
258594011110	G-X-X-G motif; other site
258594011111	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
258594011112	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
258594011113	putative translocon binding site; other site
258594011114	protein-rRNA interface [nucleotide binding]; other site
258594011115	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
258594011116	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
258594011117	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
258594011118	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
258594011119	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
258594011120	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
258594011121	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
258594011122	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
258594011123	elongation factor Tu; Reviewed; Region: PRK00049
258594011124	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
258594011125	G1 box; other site
258594011126	GEF interaction site [polypeptide binding]; other site
258594011127	GTP/Mg2+ binding site [chemical binding]; other site
258594011128	Switch I region; other site
258594011129	G2 box; other site
258594011130	G3 box; other site
258594011131	Switch II region; other site
258594011132	G4 box; other site
258594011133	G5 box; other site
258594011134	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
258594011135	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
258594011136	Antibiotic Binding Site [chemical binding]; other site
258594011137	elongation factor G; Reviewed; Region: PRK00007
258594011138	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
258594011139	G1 box; other site
258594011140	putative GEF interaction site [polypeptide binding]; other site
258594011141	GTP/Mg2+ binding site [chemical binding]; other site
258594011142	Switch I region; other site
258594011143	G2 box; other site
258594011144	G3 box; other site
258594011145	Switch II region; other site
258594011146	G4 box; other site
258594011147	G5 box; other site
258594011148	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
258594011149	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
258594011150	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
258594011151	30S ribosomal protein S7; Validated; Region: PRK05302
258594011152	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
258594011153	S17 interaction site [polypeptide binding]; other site
258594011154	S8 interaction site; other site
258594011155	16S rRNA interaction site [nucleotide binding]; other site
258594011156	streptomycin interaction site [chemical binding]; other site
258594011157	23S rRNA interaction site [nucleotide binding]; other site
258594011158	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
258594011159	Helix-turn-helix domain; Region: HTH_18; pfam12833
258594011160	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594011161	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594011162	S-adenosylmethionine binding site [chemical binding]; other site
258594011163	Methyltransferase domain; Region: Methyltransf_12; pfam08242
258594011164	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
258594011165	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
258594011166	metal-binding site [ion binding]
258594011167	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
258594011168	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594011169	motif II; other site
258594011170	5 probable transmembrane helices predicted byTMHMM2.0
258594011171	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
258594011172	DNA binding residues [nucleotide binding]
258594011173	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
258594011174	dimer interface [polypeptide binding]; other site
258594011175	putative metal binding site [ion binding]; other site
258594011176	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594011177	Major Facilitator Superfamily; Region: MFS_1; pfam07690
258594011178	putative substrate translocation pore; other site
258594011179	12 probable transmembrane helices predicted byTMHMM2.0
258594011180	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
258594011181	dimer interface [polypeptide binding]; other site
258594011182	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
258594011183	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
258594011184	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
258594011185	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
258594011186	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
258594011187	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594011188	Walker A/P-loop; other site
258594011189	ATP binding site [chemical binding]; other site
258594011190	Q-loop/lid; other site
258594011191	ABC transporter signature motif; other site
258594011192	Walker B; other site
258594011193	D-loop; other site
258594011194	H-loop/switch region; other site
258594011195	5 probable transmembrane helices predicted byTMHMM2.0
258594011196	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
258594011197	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
258594011198	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
258594011199	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
258594011200	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
258594011201	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
258594011202	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
258594011203	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
258594011204	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
258594011205	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
258594011206	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
258594011207	DNA binding site [nucleotide binding]
258594011208	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
258594011209	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
258594011210	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
258594011211	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
258594011212	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
258594011213	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
258594011214	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
258594011215	RPB11 interaction site [polypeptide binding]; other site
258594011216	RPB12 interaction site [polypeptide binding]; other site
258594011217	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
258594011218	RPB3 interaction site [polypeptide binding]; other site
258594011219	RPB1 interaction site [polypeptide binding]; other site
258594011220	RPB11 interaction site [polypeptide binding]; other site
258594011221	RPB10 interaction site [polypeptide binding]; other site
258594011222	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
258594011223	L11 interface [polypeptide binding]; other site
258594011224	putative EF-Tu interaction site [polypeptide binding]; other site
258594011225	putative EF-G interaction site [polypeptide binding]; other site
258594011226	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
258594011227	23S rRNA interface [nucleotide binding]; other site
258594011228	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
258594011229	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
258594011230	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
258594011231	NAD binding site [chemical binding]; other site
258594011232	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
258594011233	mRNA/rRNA interface [nucleotide binding]; other site
258594011234	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
258594011235	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
258594011236	23S rRNA interface [nucleotide binding]; other site
258594011237	L7/L12 interface [polypeptide binding]; other site
258594011238	putative thiostrepton binding site; other site
258594011239	L25 interface [polypeptide binding]; other site
258594011240	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
258594011241	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
258594011242	putative homodimer interface [polypeptide binding]; other site
258594011243	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
258594011244	heterodimer interface [polypeptide binding]; other site
258594011245	homodimer interface [polypeptide binding]; other site
258594011246	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
258594011247	1 probable transmembrane helix predicted byTMHMM2.0
258594011248	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
258594011249	1 probable transmembrane helix predicted byTMHMM2.0
258594011250	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
258594011251	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
258594011252	1 probable transmembrane helix predicted byTMHMM2.0
258594011253	tonB-system energizer ExbB; Region: exbB; TIGR02797
258594011254	4 probable transmembrane helices predicted byTMHMM2.0
258594011255	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
258594011256	heme binding pocket [chemical binding]; other site
258594011257	heme ligand [chemical binding]; other site
258594011258	Secretin and TonB N terminus short domain; Region: STN; smart00965
258594011259	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
258594011260	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
258594011261	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
258594011262	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
258594011263	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
258594011264	FecR protein; Region: FecR; pfam04773
258594011265	1 probable transmembrane helix predicted byTMHMM2.0
258594011266	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
258594011267	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594011268	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
258594011269	DNA binding residues [nucleotide binding]
258594011270	elongation factor Tu; Reviewed; Region: PRK00049
258594011271	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
258594011272	G1 box; other site
258594011273	GEF interaction site [polypeptide binding]; other site
258594011274	GTP/Mg2+ binding site [chemical binding]; other site
258594011275	Switch I region; other site
258594011276	G2 box; other site
258594011277	G3 box; other site
258594011278	Switch II region; other site
258594011279	G4 box; other site
258594011280	G5 box; other site
258594011281	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
258594011282	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
258594011283	Antibiotic Binding Site [chemical binding]; other site
258594011284	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
258594011285	Beta-lactamase; Region: Beta-lactamase; pfam00144
258594011286	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
258594011287	classical (c) SDRs; Region: SDR_c; cd05233
258594011288	NAD(P) binding site [chemical binding]; other site
258594011289	active site
258594011290	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
258594011291	catalytic core [active]
258594011292	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
258594011293	classical (c) SDRs; Region: SDR_c; cd05233
258594011294	NAD(P) binding site [chemical binding]; other site
258594011295	active site
258594011296	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
258594011297	Phosphotransferase enzyme family; Region: APH; pfam01636
258594011298	putative active site [active]
258594011299	putative substrate binding site [chemical binding]; other site
258594011300	ATP binding site [chemical binding]; other site
258594011301	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594011302	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594011303	active site
258594011304	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594011305	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594011306	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
258594011307	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
258594011308	13 probable transmembrane helices predicted byTMHMM2.0
258594011309	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594011310	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594011311	Walker A/P-loop; other site
258594011312	ATP binding site [chemical binding]; other site
258594011313	Q-loop/lid; other site
258594011314	ABC transporter signature motif; other site
258594011315	Walker B; other site
258594011316	D-loop; other site
258594011317	H-loop/switch region; other site
258594011318	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594011319	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594011320	Walker A/P-loop; other site
258594011321	ATP binding site [chemical binding]; other site
258594011322	Q-loop/lid; other site
258594011323	ABC transporter signature motif; other site
258594011324	Walker B; other site
258594011325	D-loop; other site
258594011326	H-loop/switch region; other site
258594011327	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594011328	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594011329	TM-ABC transporter signature motif; other site
258594011330	8 probable transmembrane helices predicted byTMHMM2.0
258594011331	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594011332	TM-ABC transporter signature motif; other site
258594011333	8 probable transmembrane helices predicted byTMHMM2.0
258594011334	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594011335	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
258594011336	putative ligand binding site [chemical binding]; other site
258594011337	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
258594011338	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
258594011339	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594011340	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
258594011341	acyl-activating enzyme (AAE) consensus motif; other site
258594011342	acyl-activating enzyme (AAE) consensus motif; other site
258594011343	putative AMP binding site [chemical binding]; other site
258594011344	putative active site [active]
258594011345	putative CoA binding site [chemical binding]; other site
258594011346	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594011347	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594011348	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
258594011349	lipid-transfer protein; Provisional; Region: PRK08256
258594011350	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
258594011351	active site
258594011352	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
258594011353	active site
258594011354	catalytic site [active]
258594011355	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
258594011356	active site
258594011357	catalytic site [active]
258594011358	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
258594011359	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594011360	NAD(P) binding site [chemical binding]; other site
258594011361	active site
258594011362	enoyl-CoA hydratase; Provisional; Region: PRK08140
258594011363	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594011364	substrate binding site [chemical binding]; other site
258594011365	oxyanion hole (OAH) forming residues; other site
258594011366	trimer interface [polypeptide binding]; other site
258594011367	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
258594011368	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
258594011369	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
258594011370	Multicopper oxidase; Region: Cu-oxidase; pfam00394
258594011371	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
258594011372	putative catalytic site [active]
258594011373	putative phosphate binding site [ion binding]; other site
258594011374	active site
258594011375	metal binding site A [ion binding]; metal-binding site
258594011376	DNA binding site [nucleotide binding]
258594011377	putative AP binding site [nucleotide binding]; other site
258594011378	putative metal binding site B [ion binding]; other site
258594011379	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
258594011380	dimerization interface [polypeptide binding]; other site
258594011381	metal binding site [ion binding]; metal-binding site
258594011382	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
258594011383	hydroperoxidase II; Provisional; Region: katE; PRK11249
258594011384	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
258594011385	heme binding pocket [chemical binding]; other site
258594011386	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
258594011387	domain interactions; other site
258594011388	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
258594011389	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
258594011390	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
258594011391	active site
258594011392	catalytic site [active]
258594011393	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
258594011394	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
258594011395	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
258594011396	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
258594011397	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
258594011398	protein binding site [polypeptide binding]; other site
258594011399	1 probable transmembrane helix predicted byTMHMM2.0
258594011400	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
258594011401	Peptidase family M50; Region: Peptidase_M50; pfam02163
258594011402	active site
258594011403	putative substrate binding region [chemical binding]; other site
258594011404	5 probable transmembrane helices predicted byTMHMM2.0
258594011405	CheB methylesterase; Region: CheB_methylest; pfam01339
258594011406	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
258594011407	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
258594011408	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594011409	S-adenosylmethionine binding site [chemical binding]; other site
258594011410	PAS domain; Region: PAS_10; pfam13596
258594011411	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
258594011412	HWE histidine kinase; Region: HWE_HK; smart00911
258594011413	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594011414	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594011415	ligand binding site [chemical binding]; other site
258594011416	flexible hinge region; other site
258594011417	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
258594011418	putative switch regulator; other site
258594011419	non-specific DNA interactions [nucleotide binding]; other site
258594011420	DNA binding site [nucleotide binding]
258594011421	sequence specific DNA binding site [nucleotide binding]; other site
258594011422	putative cAMP binding site [chemical binding]; other site
258594011423	1 probable transmembrane helix predicted byTMHMM2.0
258594011424	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
258594011425	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
258594011426	active site
258594011427	substrate binding site [chemical binding]; other site
258594011428	metal binding site [ion binding]; metal-binding site
258594011429	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
258594011430	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
258594011431	Substrate binding site; other site
258594011432	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
258594011433	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
258594011434	3 probable transmembrane helices predicted byTMHMM2.0
258594011435	putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325
258594011436	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594011437	non-specific DNA binding site [nucleotide binding]; other site
258594011438	sequence-specific DNA binding site [nucleotide binding]; other site
258594011439	salt bridge; other site
258594011440	major curlin subunit; Provisional; Region: csgA; PRK10051
258594011441	1 probable transmembrane helix predicted byTMHMM2.0
258594011442	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
258594011443	Curlin associated repeat; Region: Curlin_rpt; pfam07012
258594011444	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
258594011445	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
258594011446	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
258594011447	1 probable transmembrane helix predicted byTMHMM2.0
258594011448	Condensation domain; Region: Condensation; pfam00668
258594011449	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
258594011450	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
258594011451	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
258594011452	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
258594011453	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
258594011454	active site
258594011455	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
258594011456	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
258594011457	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
258594011458	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
258594011459	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
258594011460	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594011461	catalytic residue [active]
258594011462	Condensation domain; Region: Condensation; pfam00668
258594011463	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
258594011464	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
258594011465	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
258594011466	acyl-activating enzyme (AAE) consensus motif; other site
258594011467	AMP binding site [chemical binding]; other site
258594011468	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
258594011469	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
258594011470	acyl-activating enzyme (AAE) consensus motif; other site
258594011471	AMP binding site [chemical binding]; other site
258594011472	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
258594011473	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
258594011474	11 probable transmembrane helices predicted byTMHMM2.0
258594011475	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
258594011476	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
258594011477	1 probable transmembrane helix predicted byTMHMM2.0
258594011478	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
258594011479	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
258594011480	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
258594011481	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
258594011482	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
258594011483	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
258594011484	10 probable transmembrane helices predicted byTMHMM2.0
258594011485	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
258594011486	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
258594011487	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
258594011488	active site
258594011489	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
258594011490	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
258594011491	11 probable transmembrane helices predicted byTMHMM2.0
258594011492	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
258594011493	10 probable transmembrane helices predicted byTMHMM2.0
258594011494	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
258594011495	inhibitor-cofactor binding pocket; inhibition site
258594011496	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594011497	catalytic residue [active]
258594011498	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
258594011499	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
258594011500	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
258594011501	putative ADP-binding pocket [chemical binding]; other site
258594011502	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
258594011503	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
258594011504	active site
258594011505	metal binding site [ion binding]; metal-binding site
258594011506	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
258594011507	Chain length determinant protein; Region: Wzz; cl15801
258594011508	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
258594011509	2 probable transmembrane helices predicted byTMHMM2.0
258594011510	Bacterial sugar transferase; Region: Bac_transf; pfam02397
258594011511	1 probable transmembrane helix predicted byTMHMM2.0
258594011512	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
258594011513	1 probable transmembrane helix predicted byTMHMM2.0
258594011514	O-Antigen ligase; Region: Wzy_C; pfam04932
258594011515	11 probable transmembrane helices predicted byTMHMM2.0
258594011516	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
258594011517	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
258594011518	SLBB domain; Region: SLBB; pfam10531
258594011519	3 probable transmembrane helices predicted byTMHMM2.0
258594011520	1 probable transmembrane helix predicted byTMHMM2.0
258594011521	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
258594011522	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
258594011523	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
258594011524	1 probable transmembrane helix predicted byTMHMM2.0
258594011525	Sensors of blue-light using FAD; Region: BLUF; smart01034
258594011526	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
258594011527	1 probable transmembrane helix predicted byTMHMM2.0
258594011528	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
258594011529	Predicted helicase [General function prediction only]; Region: COG4889
258594011530	Predicted helicase [General function prediction only]; Region: COG4889
258594011531	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
258594011532	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
258594011533	putative NAD(P) binding site [chemical binding]; other site
258594011534	putative active site [active]
258594011535	1 probable transmembrane helix predicted byTMHMM2.0
258594011536	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594011537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594011538	active site
258594011539	phosphorylation site [posttranslational modification]
258594011540	intermolecular recognition site; other site
258594011541	dimerization interface [polypeptide binding]; other site
258594011542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
258594011543	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
258594011544	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
258594011545	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
258594011546	6 probable transmembrane helices predicted byTMHMM2.0
258594011547	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
258594011548	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
258594011549	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
258594011550	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
258594011551	Walker A/P-loop; other site
258594011552	ATP binding site [chemical binding]; other site
258594011553	Q-loop/lid; other site
258594011554	ABC transporter signature motif; other site
258594011555	Walker B; other site
258594011556	D-loop; other site
258594011557	H-loop/switch region; other site
258594011558	Predicted amidohydrolase [General function prediction only]; Region: COG0388
258594011559	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
258594011560	active site
258594011561	catalytic triad [active]
258594011562	dimer interface [polypeptide binding]; other site
258594011563	Predicted amidohydrolase [General function prediction only]; Region: COG0388
258594011564	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
258594011565	active site
258594011566	catalytic triad [active]
258594011567	dimer interface [polypeptide binding]; other site
258594011568	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594011569	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594011570	LysR substrate binding domain; Region: LysR_substrate; pfam03466
258594011571	dimerization interface [polypeptide binding]; other site
258594011572	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
258594011573	N-acetyl-D-glucosamine binding site [chemical binding]; other site
258594011574	catalytic residue [active]
258594011575	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
258594011576	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
258594011577	GTP cyclohydrolase I; Provisional; Region: PLN03044
258594011578	active site
258594011579	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
258594011580	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
258594011581	trimerization site [polypeptide binding]; other site
258594011582	active site
258594011583	Predicted periplasmic protein [Function unknown]; Region: COG3904
258594011584	hypothetical protein; Validated; Region: PRK00041
258594011585	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
258594011586	1 probable transmembrane helix predicted byTMHMM2.0
258594011587	4 probable transmembrane helices predicted byTMHMM2.0
258594011588	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
258594011589	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
258594011590	transmembrane helices; other site
258594011591	10 probable transmembrane helices predicted byTMHMM2.0
258594011592	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
258594011593	DNA-binding site [nucleotide binding]; DNA binding site
258594011594	RNA-binding motif; other site
258594011595	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
258594011596	1 probable transmembrane helix predicted byTMHMM2.0
258594011597	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594011598	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594011599	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
258594011600	Methyltransferase domain; Region: Methyltransf_24; pfam13578
258594011601	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594011602	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
258594011603	putative substrate translocation pore; other site
258594011604	11 probable transmembrane helices predicted byTMHMM2.0
258594011605	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
258594011606	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
258594011607	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
258594011608	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
258594011609	active site
258594011610	dimer interface [polypeptide binding]; other site
258594011611	motif 1; other site
258594011612	motif 2; other site
258594011613	motif 3; other site
258594011614	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
258594011615	anticodon binding site; other site
258594011616	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
258594011617	putative FMN binding site [chemical binding]; other site
258594011618	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
258594011619	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
258594011620	active site
258594011621	PAS domain S-box; Region: sensory_box; TIGR00229
258594011622	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594011623	putative active site [active]
258594011624	heme pocket [chemical binding]; other site
258594011625	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594011626	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594011627	metal binding site [ion binding]; metal-binding site
258594011628	active site
258594011629	I-site; other site
258594011630	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594011631	hypothetical protein; Provisional; Region: PRK10279
258594011632	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
258594011633	nucleophile elbow; other site
258594011634	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
258594011635	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
258594011636	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
258594011637	4 probable transmembrane helices predicted byTMHMM2.0
258594011638	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
258594011639	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594011640	N-terminal plug; other site
258594011641	ligand-binding site [chemical binding]; other site
258594011642	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594011643	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594011644	FOG: CBS domain [General function prediction only]; Region: COG0517
258594011645	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
258594011646	Rhomboid family; Region: Rhomboid; cl11446
258594011647	5 probable transmembrane helices predicted byTMHMM2.0
258594011648	PAS domain; Region: PAS_5; pfam07310
258594011649	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
258594011650	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594011651	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
258594011652	PilZ domain; Region: PilZ; pfam07238
258594011653	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
258594011654	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
258594011655	MarR family; Region: MarR_2; pfam12802
258594011656	Porin subfamily; Region: Porin_2; pfam02530
258594011657	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
258594011658	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
258594011659	trimer interface [polypeptide binding]; other site
258594011660	putative metal binding site [ion binding]; other site
258594011661	3 probable transmembrane helices predicted byTMHMM2.0
258594011662	1 probable transmembrane helix predicted byTMHMM2.0
258594011663	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
258594011664	serine acetyltransferase; Provisional; Region: cysE; PRK11132
258594011665	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
258594011666	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
258594011667	trimer interface [polypeptide binding]; other site
258594011668	active site
258594011669	substrate binding site [chemical binding]; other site
258594011670	CoA binding site [chemical binding]; other site
258594011671	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
258594011672	1 probable transmembrane helix predicted byTMHMM2.0
258594011673	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
258594011674	salicylate hydroxylase; Provisional; Region: PRK08163
258594011675	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
258594011676	1 probable transmembrane helix predicted byTMHMM2.0
258594011677	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
258594011678	Ligand Binding Site [chemical binding]; other site
258594011679	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
258594011680	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594011681	Coenzyme A binding pocket [chemical binding]; other site
258594011682	Fic family protein [Function unknown]; Region: COG3177
258594011683	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
258594011684	Fic/DOC family; Region: Fic; pfam02661
258594011685	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
258594011686	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
258594011687	metal binding site [ion binding]; metal-binding site
258594011688	putative dimer interface [polypeptide binding]; other site
258594011689	amidase; Provisional; Region: PRK07042
258594011690	Amidase; Region: Amidase; pfam01425
258594011691	enoyl-CoA hydratase; Provisional; Region: PRK08260
258594011692	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594011693	substrate binding site [chemical binding]; other site
258594011694	oxyanion hole (OAH) forming residues; other site
258594011695	trimer interface [polypeptide binding]; other site
258594011696	Putative cyclase; Region: Cyclase; pfam04199
258594011697	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
258594011698	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
258594011699	Transcriptional regulators [Transcription]; Region: GntR; COG1802
258594011700	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
258594011701	DNA-binding site [nucleotide binding]; DNA binding site
258594011702	FCD domain; Region: FCD; pfam07729
258594011703	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
258594011704	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
258594011705	active site
258594011706	acyl-activating enzyme (AAE) consensus motif; other site
258594011707	putative CoA binding site [chemical binding]; other site
258594011708	AMP binding site [chemical binding]; other site
258594011709	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
258594011710	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
258594011711	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
258594011712	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594011713	substrate binding site [chemical binding]; other site
258594011714	oxyanion hole (OAH) forming residues; other site
258594011715	trimer interface [polypeptide binding]; other site
258594011716	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
258594011717	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594011718	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
258594011719	substrate binding pocket [chemical binding]; other site
258594011720	FAD binding site [chemical binding]; other site
258594011721	catalytic base [active]
258594011722	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
258594011723	putative active site [active]
258594011724	homotetrameric interface [polypeptide binding]; other site
258594011725	metal binding site [ion binding]; metal-binding site
258594011726	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
258594011727	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
258594011728	tetrameric interface [polypeptide binding]; other site
258594011729	NAD binding site [chemical binding]; other site
258594011730	catalytic residues [active]
258594011731	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594011732	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594011733	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
258594011734	CoenzymeA binding site [chemical binding]; other site
258594011735	subunit interaction site [polypeptide binding]; other site
258594011736	PHB binding site; other site
258594011737	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
258594011738	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594011739	substrate binding site [chemical binding]; other site
258594011740	oxyanion hole (OAH) forming residues; other site
258594011741	trimer interface [polypeptide binding]; other site
258594011742	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594011743	Major Facilitator Superfamily; Region: MFS_1; pfam07690
258594011744	putative substrate translocation pore; other site
258594011745	12 probable transmembrane helices predicted byTMHMM2.0
258594011746	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
258594011747	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
258594011748	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
258594011749	frameshift;possible transcriptional regulator
258594011750	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
258594011751	carboxyltransferase (CT) interaction site; other site
258594011752	biotinylation site [posttranslational modification]; other site
258594011753	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
258594011754	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
258594011755	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
258594011756	DctM-like transporters; Region: DctM; pfam06808
258594011757	17 probable transmembrane helices predicted byTMHMM2.0
258594011758	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
258594011759	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
258594011760	DUF35 OB-fold domain; Region: DUF35; pfam01796
258594011761	thiolase; Provisional; Region: PRK06158
258594011762	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
258594011763	active site
258594011764	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
258594011765	CoA-transferase family III; Region: CoA_transf_3; pfam02515
258594011766	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
258594011767	acyl-CoA synthetase; Validated; Region: PRK07470
258594011768	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594011769	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
258594011770	acyl-activating enzyme (AAE) consensus motif; other site
258594011771	acyl-activating enzyme (AAE) consensus motif; other site
258594011772	putative AMP binding site [chemical binding]; other site
258594011773	putative active site [active]
258594011774	putative CoA binding site [chemical binding]; other site
258594011775	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
258594011776	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
258594011777	active site
258594011778	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
258594011779	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
258594011780	putative NAD(P) binding site [chemical binding]; other site
258594011781	active site
258594011782	putative substrate binding site [chemical binding]; other site
258594011783	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
258594011784	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594011785	dimer interface [polypeptide binding]; other site
258594011786	conserved gate region; other site
258594011787	putative PBP binding loops; other site
258594011788	ABC-ATPase subunit interface; other site
258594011789	6 probable transmembrane helices predicted byTMHMM2.0
258594011790	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594011791	dimer interface [polypeptide binding]; other site
258594011792	conserved gate region; other site
258594011793	putative PBP binding loops; other site
258594011794	ABC-ATPase subunit interface; other site
258594011795	6 probable transmembrane helices predicted byTMHMM2.0
258594011796	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
258594011797	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
258594011798	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
258594011799	Walker A/P-loop; other site
258594011800	ATP binding site [chemical binding]; other site
258594011801	Q-loop/lid; other site
258594011802	ABC transporter signature motif; other site
258594011803	Walker B; other site
258594011804	D-loop; other site
258594011805	H-loop/switch region; other site
258594011806	TOBE domain; Region: TOBE_2; pfam08402
258594011807	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
258594011808	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
258594011809	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594011810	NAD(P) binding site [chemical binding]; other site
258594011811	active site
258594011812	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
258594011813	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594011814	NAD(P) binding site [chemical binding]; other site
258594011815	active site
258594011816	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
258594011817	Transposase; Region: DEDD_Tnp_IS110; pfam01548
258594011818	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
258594011819	IS element
258594011820	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
258594011821	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
258594011822	1 probable transmembrane helix predicted byTMHMM2.0
258594011823	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
258594011824	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
258594011825	1 probable transmembrane helix predicted byTMHMM2.0
258594011826	tonB-system energizer ExbB; Region: exbB; TIGR02797
258594011827	3 probable transmembrane helices predicted byTMHMM2.0
258594011828	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
258594011829	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
258594011830	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594011831	N-terminal plug; other site
258594011832	ligand-binding site [chemical binding]; other site
258594011833	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594011834	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594011835	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594011836	1 probable transmembrane helix predicted byTMHMM2.0
258594011837	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
258594011838	Protein export membrane protein; Region: SecD_SecF; cl14618
258594011839	10 probable transmembrane helices predicted byTMHMM2.0
258594011840	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
258594011841	putative active site [active]
258594011842	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
258594011843	CoA-transferase family III; Region: CoA_transf_3; pfam02515
258594011844	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
258594011845	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594011846	putative ligand binding site [chemical binding]; other site
258594011847	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
258594011848	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
258594011849	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
258594011850	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
258594011851	protein binding site [polypeptide binding]; other site
258594011852	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
258594011853	protein binding site [polypeptide binding]; other site
258594011854	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
258594011855	2 probable transmembrane helices predicted byTMHMM2.0
258594011856	FtsH protease regulator HflC; Provisional; Region: PRK11029
258594011857	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
258594011858	1 probable transmembrane helix predicted byTMHMM2.0
258594011859	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
258594011860	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
258594011861	HflK protein; Region: hflK; TIGR01933
258594011862	1 probable transmembrane helix predicted byTMHMM2.0
258594011863	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
258594011864	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
258594011865	NADP+ binding site [chemical binding]; other site
258594011866	folate binding site [chemical binding]; other site
258594011867	thymidylate synthase; Reviewed; Region: thyA; PRK01827
258594011868	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
258594011869	dimerization interface [polypeptide binding]; other site
258594011870	active site
258594011871	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
258594011872	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
258594011873	10 probable transmembrane helices predicted byTMHMM2.0
258594011874	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
258594011875	4 probable transmembrane helices predicted byTMHMM2.0
258594011876	Chromate transporter; Region: Chromate_transp; pfam02417
258594011877	5 probable transmembrane helices predicted byTMHMM2.0
258594011878	Chromate transporter; Region: Chromate_transp; pfam02417
258594011879	5 probable transmembrane helices predicted byTMHMM2.0
258594011880	Stringent starvation protein B; Region: SspB; pfam04386
258594011881	fumarate hydratase; Reviewed; Region: fumC; PRK00485
258594011882	Class II fumarases; Region: Fumarase_classII; cd01362
258594011883	active site
258594011884	tetramer interface [polypeptide binding]; other site
258594011885	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
258594011886	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
258594011887	1 probable transmembrane helix predicted byTMHMM2.0
258594011888	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
258594011889	FAD binding domain; Region: FAD_binding_4; pfam01565
258594011890	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
258594011891	active site
258594011892	2 probable transmembrane helices predicted byTMHMM2.0
258594011893	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
258594011894	Part of AAA domain; Region: AAA_19; pfam13245
258594011895	Family description; Region: UvrD_C_2; pfam13538
258594011896	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
258594011897	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
258594011898	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
258594011899	Walker A/P-loop; other site
258594011900	ATP binding site [chemical binding]; other site
258594011901	Q-loop/lid; other site
258594011902	ABC transporter signature motif; other site
258594011903	Walker B; other site
258594011904	D-loop; other site
258594011905	H-loop/switch region; other site
258594011906	ABC-2 type transporter; Region: ABC2_membrane; cl17235
258594011907	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
258594011908	7 probable transmembrane helices predicted byTMHMM2.0
258594011909	2 probable transmembrane helices predicted byTMHMM2.0
258594011910	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
258594011911	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594011912	S-adenosylmethionine binding site [chemical binding]; other site
258594011913	12 probable transmembrane helices predicted byTMHMM2.0
258594011914	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
258594011915	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
258594011916	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
258594011917	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594011918	S-adenosylmethionine binding site [chemical binding]; other site
258594011919	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
258594011920	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
258594011921	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
258594011922	active site
258594011923	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
258594011924	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594011925	putative substrate translocation pore; other site
258594011926	12 probable transmembrane helices predicted byTMHMM2.0
258594011927	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
258594011928	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
258594011929	nucleotide binding pocket [chemical binding]; other site
258594011930	K-X-D-G motif; other site
258594011931	catalytic site [active]
258594011932	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
258594011933	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
258594011934	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
258594011935	Dimer interface [polypeptide binding]; other site
258594011936	BRCT sequence motif; other site
258594011937	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
258594011938	GIY-YIG motif/motif A; other site
258594011939	putative active site [active]
258594011940	putative metal binding site [ion binding]; other site
258594011941	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
258594011942	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
258594011943	Walker A/P-loop; other site
258594011944	ATP binding site [chemical binding]; other site
258594011945	Q-loop/lid; other site
258594011946	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
258594011947	ABC transporter signature motif; other site
258594011948	Walker B; other site
258594011949	D-loop; other site
258594011950	H-loop/switch region; other site
258594011951	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
258594011952	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
258594011953	TPR motif; other site
258594011954	binding surface
258594011955	1 probable transmembrane helix predicted byTMHMM2.0
258594011956	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
258594011957	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
258594011958	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
258594011959	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
258594011960	nucleotide binding site [chemical binding]; other site
258594011961	SulA interaction site; other site
258594011962	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
258594011963	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
258594011964	Cell division protein FtsA; Region: FtsA; smart00842
258594011965	Cell division protein FtsA; Region: FtsA; pfam14450
258594011966	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
258594011967	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
258594011968	Cell division protein FtsQ; Region: FtsQ; pfam03799
258594011969	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
258594011970	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
258594011971	ATP-grasp domain; Region: ATP-grasp_4; cl17255
258594011972	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
258594011973	10 probable transmembrane helices predicted byTMHMM2.0
258594011974	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
258594011975	4 probable transmembrane helices predicted byTMHMM2.0
258594011976	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
258594011977	FAD binding domain; Region: FAD_binding_4; pfam01565
258594011978	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
258594011979	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
258594011980	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
258594011981	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
258594011982	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
258594011983	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
258594011984	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
258594011985	active site
258594011986	homodimer interface [polypeptide binding]; other site
258594011987	cell division protein FtsW; Region: ftsW; TIGR02614
258594011988	10 probable transmembrane helices predicted byTMHMM2.0
258594011989	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
258594011990	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
258594011991	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
258594011992	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
258594011993	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
258594011994	Mg++ binding site [ion binding]; other site
258594011995	putative catalytic motif [active]
258594011996	putative substrate binding site [chemical binding]; other site
258594011997	10 probable transmembrane helices predicted byTMHMM2.0
258594011998	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
258594011999	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
258594012000	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
258594012001	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
258594012002	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
258594012003	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
258594012004	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
258594012005	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
258594012006	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
258594012007	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
258594012008	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
258594012009	1 probable transmembrane helix predicted byTMHMM2.0
258594012010	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
258594012011	1 probable transmembrane helix predicted byTMHMM2.0
258594012012	MraW methylase family; Region: Methyltransf_5; cl17771
258594012013	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
258594012014	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
258594012015	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
258594012016	amidase catalytic site [active]
258594012017	Zn binding residues [ion binding]; other site
258594012018	substrate binding site [chemical binding]; other site
258594012019	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
258594012020	Fic/DOC family; Region: Fic; cl00960
258594012021	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
258594012022	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594012023	putative substrate translocation pore; other site
258594012024	13 probable transmembrane helices predicted byTMHMM2.0
258594012025	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
258594012026	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594012027	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594012028	1 probable transmembrane helix predicted byTMHMM2.0
258594012029	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594012030	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594012031	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
258594012032	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
258594012033	1 probable transmembrane helix predicted byTMHMM2.0
258594012034	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
258594012035	HAMP domain; Region: HAMP; pfam00672
258594012036	dimerization interface [polypeptide binding]; other site
258594012037	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594012038	dimer interface [polypeptide binding]; other site
258594012039	putative CheW interface [polypeptide binding]; other site
258594012040	2 probable transmembrane helices predicted byTMHMM2.0
258594012041	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
258594012042	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
258594012043	Autotransporter beta-domain; Region: Autotransporter; smart00869
258594012044	1 probable transmembrane helix predicted byTMHMM2.0
258594012045	epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247
258594012046	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594012047	motif II; other site
258594012048	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
258594012049	B12 binding site [chemical binding]; other site
258594012050	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
258594012051	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594012052	FeS/SAM binding site; other site
258594012053	short chain dehydrogenase; Provisional; Region: PRK07326
258594012054	classical (c) SDR, subgroup 4; Region: SDR_c4; cd08929
258594012055	putative NAD(P) binding site [chemical binding]; other site
258594012056	homodimer interface [polypeptide binding]; other site
258594012057	active site
258594012058	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
258594012059	classical (c) SDRs; Region: SDR_c; cd05233
258594012060	NAD(P) binding site [chemical binding]; other site
258594012061	active site
258594012062	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
258594012063	Sodium Bile acid symporter family; Region: SBF; cl17470
258594012064	10 probable transmembrane helices predicted byTMHMM2.0
258594012065	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
258594012066	ArsC family; Region: ArsC; pfam03960
258594012067	catalytic residues [active]
258594012068	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
258594012069	Low molecular weight phosphatase family; Region: LMWPc; cd00115
258594012070	active site
258594012071	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594012072	dimerization interface [polypeptide binding]; other site
258594012073	putative DNA binding site [nucleotide binding]; other site
258594012074	putative Zn2+ binding site [ion binding]; other site
258594012075	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
258594012076	Predicted permeases [General function prediction only]; Region: COG0701
258594012077	9 probable transmembrane helices predicted byTMHMM2.0
258594012078	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594012079	dimerization interface [polypeptide binding]; other site
258594012080	putative DNA binding site [nucleotide binding]; other site
258594012081	putative Zn2+ binding site [ion binding]; other site
258594012082	8 probable transmembrane helices predicted byTMHMM2.0
258594012083	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594012084	dimerization interface [polypeptide binding]; other site
258594012085	putative DNA binding site [nucleotide binding]; other site
258594012086	putative Zn2+ binding site [ion binding]; other site
258594012087	Methyltransferase domain; Region: Methyltransf_31; pfam13847
258594012088	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594012089	S-adenosylmethionine binding site [chemical binding]; other site
258594012090	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
258594012091	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
258594012092	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594012093	catalytic residue [active]
258594012094	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
258594012095	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
258594012096	1 probable transmembrane helix predicted byTMHMM2.0
258594012097	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
258594012098	1 probable transmembrane helix predicted byTMHMM2.0
258594012099	PRC-barrel domain; Region: PRC; pfam05239
258594012100	osmolarity response regulator; Provisional; Region: ompR; PRK09468
258594012101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594012102	active site
258594012103	phosphorylation site [posttranslational modification]
258594012104	intermolecular recognition site; other site
258594012105	dimerization interface [polypeptide binding]; other site
258594012106	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
258594012107	DNA binding site [nucleotide binding]
258594012108	HAMP domain; Region: HAMP; pfam00672
258594012109	dimerization interface [polypeptide binding]; other site
258594012110	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594012111	dimer interface [polypeptide binding]; other site
258594012112	phosphorylation site [posttranslational modification]
258594012113	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594012114	ATP binding site [chemical binding]; other site
258594012115	Mg2+ binding site [ion binding]; other site
258594012116	G-X-G motif; other site
258594012117	2 probable transmembrane helices predicted byTMHMM2.0
258594012118	AAI_LTSS: Alpha-Amylase Inhibitors (AAI), Lipid Transfer (LT) and Seed Storage (SS) Protein family; a protein family unique to higher plants that includes cereal-type alpha-amylase inhibitors, lipid transfer proteins, seed storage proteins, and similar...; Region: AAI_LTSS; cl07890
258594012119	8 probable transmembrane helices predicted byTMHMM2.0
258594012120	hydroxyglutarate oxidase; Provisional; Region: PRK11728
258594012121	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
258594012122	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
258594012123	thiS-thiF/thiG interaction site; other site
258594012124	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
258594012125	ThiS interaction site; other site
258594012126	putative active site [active]
258594012127	tetramer interface [polypeptide binding]; other site
258594012128	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
258594012129	thiamine phosphate binding site [chemical binding]; other site
258594012130	active site
258594012131	pyrophosphate binding site [ion binding]; other site
258594012132	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
258594012133	ThiC-associated domain; Region: ThiC-associated; pfam13667
258594012134	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
258594012135	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
258594012136	ISR1-like IS element
258594012137	Transposase; Region: HTH_Tnp_1; pfam01527
258594012138	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
258594012139	HTH-like domain; Region: HTH_21; pfam13276
258594012140	Integrase core domain; Region: rve; pfam00665
258594012141	Integrase core domain; Region: rve_3; pfam13683
258594012142	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
258594012143	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
258594012144	hypothetical protein; Provisional; Region: PRK07538
258594012145	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
258594012146	2 probable transmembrane helices predicted byTMHMM2.0
258594012147	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
258594012148	homotrimer interaction site [polypeptide binding]; other site
258594012149	putative active site [active]
258594012150	2 probable transmembrane helices predicted byTMHMM2.0
258594012151	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
258594012152	SOUL heme-binding protein; Region: SOUL; pfam04832
258594012153	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
258594012154	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
258594012155	1 probable transmembrane helix predicted byTMHMM2.0
258594012156	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
258594012157	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594012158	dimer interface [polypeptide binding]; other site
258594012159	putative CheW interface [polypeptide binding]; other site
258594012160	1 probable transmembrane helix predicted byTMHMM2.0
258594012161	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
258594012162	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
258594012163	heme binding site [chemical binding]; other site
258594012164	ferroxidase pore; other site
258594012165	ferroxidase diiron center [ion binding]; other site
258594012166	2 probable transmembrane helices predicted byTMHMM2.0
258594012167	2 probable transmembrane helices predicted byTMHMM2.0
258594012168	lytic murein transglycosylase; Region: MltB_2; TIGR02283
258594012169	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
258594012170	N-acetyl-D-glucosamine binding site [chemical binding]; other site
258594012171	catalytic residue [active]
258594012172	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
258594012173	hypothetical protein; Provisional; Region: PRK05208
258594012174	3 probable transmembrane helices predicted byTMHMM2.0
258594012175	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
258594012176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594012177	S-adenosylmethionine binding site [chemical binding]; other site
258594012178	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
258594012179	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
258594012180	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487
258594012181	putative active site [active]
258594012182	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
258594012183	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
258594012184	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
258594012185	ABC transporter; Region: ABC_tran_2; pfam12848
258594012186	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
258594012187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
258594012188	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
258594012189	1 probable transmembrane helix predicted byTMHMM2.0
258594012190	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
258594012191	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
258594012192	active site residue [active]
258594012193	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
258594012194	active site residue [active]
258594012195	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
258594012196	active site
258594012197	catalytic residue [active]
258594012198	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
258594012199	PAS domain S-box; Region: sensory_box; TIGR00229
258594012200	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594012201	putative active site [active]
258594012202	heme pocket [chemical binding]; other site
258594012203	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594012204	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594012205	metal binding site [ion binding]; metal-binding site
258594012206	active site
258594012207	I-site; other site
258594012208	2 probable transmembrane helices predicted byTMHMM2.0
258594012209	3 probable transmembrane helices predicted byTMHMM2.0
258594012210	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
258594012211	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594012212	Walker A motif; other site
258594012213	ATP binding site [chemical binding]; other site
258594012214	Walker B motif; other site
258594012215	arginine finger; other site
258594012216	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
258594012217	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
258594012218	iron-sulfur cluster [ion binding]; other site
258594012219	[2Fe-2S] cluster binding site [ion binding]; other site
258594012220	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
258594012221	alpha subunit interface [polypeptide binding]; other site
258594012222	active site
258594012223	substrate binding site [chemical binding]; other site
258594012224	Fe binding site [ion binding]; other site
258594012225	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
258594012226	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
258594012227	DNA-binding site [nucleotide binding]; DNA binding site
258594012228	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
258594012229	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
258594012230	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
258594012231	FMN-binding pocket [chemical binding]; other site
258594012232	flavin binding motif; other site
258594012233	phosphate binding motif [ion binding]; other site
258594012234	beta-alpha-beta structure motif; other site
258594012235	NAD binding pocket [chemical binding]; other site
258594012236	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
258594012237	catalytic loop [active]
258594012238	iron binding site [ion binding]; other site
258594012239	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
258594012240	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
258594012241	Strictosidine synthase; Region: Str_synth; pfam03088
258594012242	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
258594012243	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
258594012244	GIY-YIG motif/motif A; other site
258594012245	putative active site [active]
258594012246	putative metal binding site [ion binding]; other site
258594012247	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
258594012248	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
258594012249	catalytic residues [active]
258594012250	dimer interface [polypeptide binding]; other site
258594012251	amidase; Provisional; Region: PRK07487
258594012252	Amidase; Region: Amidase; cl11426
258594012253	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
258594012254	short chain dehydrogenase; Provisional; Region: PRK06500
258594012255	classical (c) SDRs; Region: SDR_c; cd05233
258594012256	NAD(P) binding site [chemical binding]; other site
258594012257	active site
258594012258	Predicted transcriptional regulators [Transcription]; Region: COG1733
258594012259	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
258594012260	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
258594012261	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
258594012262	putative active site [active]
258594012263	catalytic residue [active]
258594012264	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
258594012265	active site
258594012266	dimer interface [polypeptide binding]; other site
258594012267	SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798
258594012268	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
258594012269	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
258594012270	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
258594012271	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
258594012272	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
258594012273	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
258594012274	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
258594012275	putative active site [active]
258594012276	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
258594012277	AAA domain; Region: AAA_33; pfam13671
258594012278	ATP-binding site [chemical binding]; other site
258594012279	Gluconate-6-phosphate binding site [chemical binding]; other site
258594012280	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
258594012281	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
258594012282	active site
258594012283	motif I; other site
258594012284	motif II; other site
258594012285	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
258594012286	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
258594012287	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
258594012288	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
258594012289	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
258594012290	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
258594012291	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
258594012292	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
258594012293	active site
258594012294	homodimer interface [polypeptide binding]; other site
258594012295	catalytic site [active]
258594012296	acceptor binding site [chemical binding]; other site
258594012297	trehalose synthase; Region: treS_nterm; TIGR02456
258594012298	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
258594012299	active site
258594012300	catalytic site [active]
258594012301	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
258594012302	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
258594012303	glycogen branching enzyme; Provisional; Region: PRK05402
258594012304	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
258594012305	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
258594012306	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
258594012307	active site
258594012308	catalytic site [active]
258594012309	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
258594012310	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
258594012311	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
258594012312	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
258594012313	active site
258594012314	catalytic site [active]
258594012315	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
258594012316	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
258594012317	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
258594012318	catalytic site [active]
258594012319	active site
258594012320	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
258594012321	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
258594012322	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
258594012323	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
258594012324	active site
258594012325	catalytic site [active]
258594012326	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
258594012327	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
258594012328	2 probable transmembrane helices predicted byTMHMM2.0
258594012329	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
258594012330	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
258594012331	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
258594012332	active site
258594012333	DNA binding site [nucleotide binding]
258594012334	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
258594012335	DNA binding site [nucleotide binding]
258594012336	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
258594012337	nucleotide binding site [chemical binding]; other site
258594012338	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
258594012339	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
258594012340	putative DNA binding site [nucleotide binding]; other site
258594012341	putative homodimer interface [polypeptide binding]; other site
258594012342	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
258594012343	CPxP  motif; other site
258594012344	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
258594012345	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
258594012346	GTP binding site; other site
258594012347	6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240
258594012348	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
258594012349	putative NAD(P) binding site [chemical binding]; other site
258594012350	catalytic Zn binding site [ion binding]; other site
258594012351	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
258594012352	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
258594012353	FMN binding site [chemical binding]; other site
258594012354	substrate binding site [chemical binding]; other site
258594012355	putative catalytic residue [active]
258594012356	acyl-CoA synthetase; Validated; Region: PRK06188
258594012357	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594012358	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
258594012359	acyl-activating enzyme (AAE) consensus motif; other site
258594012360	acyl-activating enzyme (AAE) consensus motif; other site
258594012361	putative AMP binding site [chemical binding]; other site
258594012362	putative active site [active]
258594012363	putative CoA binding site [chemical binding]; other site
258594012364	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
258594012365	UreF; Region: UreF; pfam01730
258594012366	1 probable transmembrane helix predicted byTMHMM2.0
258594012367	Uncharacterized conserved protein [Function unknown]; Region: COG1359
258594012368	urease subunit alpha; Reviewed; Region: ureC; PRK13207
258594012369	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
258594012370	subunit interactions [polypeptide binding]; other site
258594012371	active site
258594012372	flap region; other site
258594012373	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
258594012374	HD domain; Region: HD_4; pfam13328
258594012375	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
258594012376	gamma-beta subunit interface [polypeptide binding]; other site
258594012377	alpha-beta subunit interface [polypeptide binding]; other site
258594012378	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
258594012379	alpha-gamma subunit interface [polypeptide binding]; other site
258594012380	beta-gamma subunit interface [polypeptide binding]; other site
258594012381	UreD urease accessory protein; Region: UreD; pfam01774
258594012382	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
258594012383	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594012384	Walker A/P-loop; other site
258594012385	ATP binding site [chemical binding]; other site
258594012386	Q-loop/lid; other site
258594012387	ABC transporter signature motif; other site
258594012388	Walker B; other site
258594012389	D-loop; other site
258594012390	H-loop/switch region; other site
258594012391	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
258594012392	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594012393	Walker A/P-loop; other site
258594012394	ATP binding site [chemical binding]; other site
258594012395	Q-loop/lid; other site
258594012396	ABC transporter signature motif; other site
258594012397	Walker B; other site
258594012398	D-loop; other site
258594012399	H-loop/switch region; other site
258594012400	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594012401	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594012402	TM-ABC transporter signature motif; other site
258594012403	9 probable transmembrane helices predicted byTMHMM2.0
258594012404	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594012405	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594012406	TM-ABC transporter signature motif; other site
258594012407	8 probable transmembrane helices predicted byTMHMM2.0
258594012408	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594012409	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
258594012410	putative ligand binding site [chemical binding]; other site
258594012411	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
258594012412	DEAD-like helicases superfamily; Region: DEXDc; smart00487
258594012413	ATP binding site [chemical binding]; other site
258594012414	Mg++ binding site [ion binding]; other site
258594012415	motif III; other site
258594012416	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
258594012417	nucleotide binding region [chemical binding]; other site
258594012418	ATP-binding site [chemical binding]; other site
258594012419	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
258594012420	rRNA binding site [nucleotide binding]; other site
258594012421	predicted 30S ribosome binding site; other site
258594012422	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
258594012423	DNA-binding site [nucleotide binding]; DNA binding site
258594012424	RNA-binding motif; other site
258594012425	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
258594012426	TadE-like protein; Region: TadE; pfam07811
258594012427	1 probable transmembrane helix predicted byTMHMM2.0
258594012428	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
258594012429	TadE-like protein; Region: TadE; pfam07811
258594012430	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
258594012431	1 probable transmembrane helix predicted byTMHMM2.0
258594012432	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
258594012433	1 probable transmembrane helix predicted byTMHMM2.0
258594012434	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
258594012435	4 probable transmembrane helices predicted byTMHMM2.0
258594012436	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
258594012437	1 probable transmembrane helix predicted byTMHMM2.0
258594012438	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
258594012439	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
258594012440	BON domain; Region: BON; pfam04972
258594012441	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
258594012442	1 probable transmembrane helix predicted byTMHMM2.0
258594012443	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
258594012444	Type IV pili component [Cell motility and secretion]; Region: COG5461
258594012445	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
258594012446	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
258594012447	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
258594012448	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
258594012449	ATP binding site [chemical binding]; other site
258594012450	Walker A motif; other site
258594012451	hexamer interface [polypeptide binding]; other site
258594012452	Walker B motif; other site
258594012453	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
258594012454	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
258594012455	4 probable transmembrane helices predicted byTMHMM2.0
258594012456	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
258594012457	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
258594012458	4 probable transmembrane helices predicted byTMHMM2.0
258594012459	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594012460	TPR repeat; Region: TPR_11; pfam13414
258594012461	binding surface
258594012462	TPR motif; other site
258594012463	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594012464	TPR motif; other site
258594012465	binding surface
258594012466	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
258594012467	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
258594012468	interface (dimer of trimers) [polypeptide binding]; other site
258594012469	Substrate-binding/catalytic site; other site
258594012470	Zn-binding sites [ion binding]; other site
258594012471	Src Homology 3 domain superfamily; Region: SH3; cl17036
258594012472	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
258594012473	NlpC/P60 family; Region: NLPC_P60; pfam00877
258594012474	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
258594012475	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
258594012476	dimer interface [polypeptide binding]; other site
258594012477	active site
258594012478	ADP-ribose binding site [chemical binding]; other site
258594012479	nudix motif; other site
258594012480	metal binding site [ion binding]; metal-binding site
258594012481	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
258594012482	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594012483	Walker A/P-loop; other site
258594012484	ATP binding site [chemical binding]; other site
258594012485	Q-loop/lid; other site
258594012486	ABC transporter signature motif; other site
258594012487	Walker B; other site
258594012488	D-loop; other site
258594012489	H-loop/switch region; other site
258594012490	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
258594012491	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
258594012492	Walker A/P-loop; other site
258594012493	ATP binding site [chemical binding]; other site
258594012494	Q-loop/lid; other site
258594012495	ABC transporter signature motif; other site
258594012496	Walker B; other site
258594012497	D-loop; other site
258594012498	H-loop/switch region; other site
258594012499	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
258594012500	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
258594012501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594012502	dimer interface [polypeptide binding]; other site
258594012503	conserved gate region; other site
258594012504	ABC-ATPase subunit interface; other site
258594012505	6 probable transmembrane helices predicted byTMHMM2.0
258594012506	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
258594012507	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594012508	dimer interface [polypeptide binding]; other site
258594012509	conserved gate region; other site
258594012510	putative PBP binding loops; other site
258594012511	ABC-ATPase subunit interface; other site
258594012512	6 probable transmembrane helices predicted byTMHMM2.0
258594012513	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
258594012514	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
258594012515	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
258594012516	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
258594012517	Cytochrome c2 [Energy production and conversion]; Region: COG3474
258594012518	1 probable transmembrane helix predicted byTMHMM2.0
258594012519	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
258594012520	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
258594012521	Ligand binding site; other site
258594012522	oligomer interface; other site
258594012523	prephenate dehydratase; Provisional; Region: PRK11899
258594012524	Prephenate dehydratase; Region: PDT; pfam00800
258594012525	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
258594012526	putative L-Phe binding site [chemical binding]; other site
258594012527	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594012528	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594012529	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
258594012530	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594012531	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594012532	1 probable transmembrane helix predicted byTMHMM2.0
258594012533	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
258594012534	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594012535	putative substrate translocation pore; other site
258594012536	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594012537	13 probable transmembrane helices predicted byTMHMM2.0
258594012538	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
258594012539	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
258594012540	FAD binding pocket [chemical binding]; other site
258594012541	FAD binding motif [chemical binding]; other site
258594012542	phosphate binding motif [ion binding]; other site
258594012543	NAD binding pocket [chemical binding]; other site
258594012544	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
258594012545	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
258594012546	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
258594012547	FAD binding site [chemical binding]; other site
258594012548	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
258594012549	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
258594012550	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
258594012551	substrate binding pocket [chemical binding]; other site
258594012552	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
258594012553	B12 binding site [chemical binding]; other site
258594012554	cobalt ligand [ion binding]; other site
258594012555	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
258594012556	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
258594012557	GIY-YIG motif/motif A; other site
258594012558	putative active site [active]
258594012559	putative metal binding site [ion binding]; other site
258594012560	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
258594012561	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
258594012562	N- and C-terminal domain interface [polypeptide binding]; other site
258594012563	active site
258594012564	MgATP binding site [chemical binding]; other site
258594012565	catalytic site [active]
258594012566	metal binding site [ion binding]; metal-binding site
258594012567	glycerol binding site [chemical binding]; other site
258594012568	homotetramer interface [polypeptide binding]; other site
258594012569	homodimer interface [polypeptide binding]; other site
258594012570	FBP binding site [chemical binding]; other site
258594012571	protein IIAGlc interface [polypeptide binding]; other site
258594012572	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
258594012573	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
258594012574	active site
258594012575	phosphorylation site [posttranslational modification]
258594012576	intermolecular recognition site; other site
258594012577	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
258594012578	NMT1-like family; Region: NMT1_2; pfam13379
258594012579	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
258594012580	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
258594012581	heme-binding site [chemical binding]; other site
258594012582	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
258594012583	heme-binding site [chemical binding]; other site
258594012584	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567
258594012585	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
258594012586	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
258594012587	sulfite reductase; Provisional; Region: PRK06214
258594012588	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
258594012589	FAD binding pocket [chemical binding]; other site
258594012590	FAD binding motif [chemical binding]; other site
258594012591	catalytic residues [active]
258594012592	NAD binding pocket [chemical binding]; other site
258594012593	phosphate binding motif [ion binding]; other site
258594012594	beta-alpha-beta structure motif; other site
258594012595	frameshift;short chain dehydrogenase
258594012596	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
258594012597	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
258594012598	active site
258594012599	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
258594012600	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594012601	active site
258594012602	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
258594012603	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
258594012604	dimer interface [polypeptide binding]; other site
258594012605	active site
258594012606	dicarboxylate--CoA ligase PimA; Region: pimA; TIGR03205
258594012607	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
258594012608	acyl-activating enzyme (AAE) consensus motif; other site
258594012609	putative AMP binding site [chemical binding]; other site
258594012610	putative active site [active]
258594012611	putative CoA binding site [chemical binding]; other site
258594012612	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
258594012613	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594012614	substrate binding site [chemical binding]; other site
258594012615	oxyanion hole (OAH) forming residues; other site
258594012616	trimer interface [polypeptide binding]; other site
258594012617	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
258594012618	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
258594012619	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
258594012620	Transcriptional regulator [Transcription]; Region: IclR; COG1414
258594012621	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
258594012622	Bacterial transcriptional regulator; Region: IclR; pfam01614
258594012623	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594012624	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594012625	Walker A/P-loop; other site
258594012626	ATP binding site [chemical binding]; other site
258594012627	Q-loop/lid; other site
258594012628	ABC transporter signature motif; other site
258594012629	Walker B; other site
258594012630	D-loop; other site
258594012631	H-loop/switch region; other site
258594012632	1 probable transmembrane helix predicted byTMHMM2.0
258594012633	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594012634	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594012635	Walker A/P-loop; other site
258594012636	ATP binding site [chemical binding]; other site
258594012637	Q-loop/lid; other site
258594012638	ABC transporter signature motif; other site
258594012639	Walker B; other site
258594012640	D-loop; other site
258594012641	H-loop/switch region; other site
258594012642	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594012643	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594012644	TM-ABC transporter signature motif; other site
258594012645	7 probable transmembrane helices predicted byTMHMM2.0
258594012646	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594012647	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594012648	TM-ABC transporter signature motif; other site
258594012649	8 probable transmembrane helices predicted byTMHMM2.0
258594012650	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
258594012651	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594012652	putative ligand binding site [chemical binding]; other site
258594012653	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
258594012654	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594012655	putative ligand binding site [chemical binding]; other site
258594012656	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
258594012657	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594012658	putative ligand binding site [chemical binding]; other site
258594012659	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
258594012660	dimerization interface [polypeptide binding]; other site
258594012661	metal binding site [ion binding]; metal-binding site
258594012662	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
258594012663	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
258594012664	Cl binding site [ion binding]; other site
258594012665	oligomer interface [polypeptide binding]; other site
258594012666	2 probable transmembrane helices predicted byTMHMM2.0
258594012667	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
258594012668	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
258594012669	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
258594012670	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
258594012671	metal binding site [ion binding]; metal-binding site
258594012672	putative dimer interface [polypeptide binding]; other site
258594012673	choline dehydrogenase; Validated; Region: PRK02106
258594012674	lycopene cyclase; Region: lycopene_cycl; TIGR01789
258594012675	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
258594012676	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
258594012677	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
258594012678	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
258594012679	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
258594012680	inhibitor-cofactor binding pocket; inhibition site
258594012681	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594012682	catalytic residue [active]
258594012683	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
258594012684	12 probable transmembrane helices predicted byTMHMM2.0
258594012685	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
258594012686	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
258594012687	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
258594012688	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594012689	FeS/SAM binding site; other site
258594012690	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
258594012691	PBP superfamily domain; Region: PBP_like_2; cl17296
258594012692	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
258594012693	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
258594012694	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
258594012695	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594012696	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
258594012697	dimerization interface [polypeptide binding]; other site
258594012698	hypothetical protein; Provisional; Region: PRK07077
258594012699	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
258594012700	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
258594012701	Active site cavity [active]
258594012702	catalytic acid [active]
258594012703	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
258594012704	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
258594012705	active site lid residues [active]
258594012706	substrate binding pocket [chemical binding]; other site
258594012707	catalytic residues [active]
258594012708	substrate-Mg2+ binding site; other site
258594012709	aspartate-rich region 1; other site
258594012710	aspartate-rich region 2; other site
258594012711	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
258594012712	active site lid residues [active]
258594012713	substrate binding pocket [chemical binding]; other site
258594012714	catalytic residues [active]
258594012715	substrate-Mg2+ binding site; other site
258594012716	aspartate-rich region 1; other site
258594012717	aspartate-rich region 2; other site
258594012718	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
258594012719	12 probable transmembrane helices predicted byTMHMM2.0
258594012720	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
258594012721	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
258594012722	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
258594012723	B12 binding site [chemical binding]; other site
258594012724	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
258594012725	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
258594012726	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
258594012727	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
258594012728	dimerization interface [polypeptide binding]; other site
258594012729	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
258594012730	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594012731	dimer interface [polypeptide binding]; other site
258594012732	putative CheW interface [polypeptide binding]; other site
258594012733	2 probable transmembrane helices predicted byTMHMM2.0
258594012734	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
258594012735	1 probable transmembrane helix predicted byTMHMM2.0
258594012736	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
258594012737	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
258594012738	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
258594012739	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
258594012740	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
258594012741	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
258594012742	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
258594012743	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
258594012744	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
258594012745	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
258594012746	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
258594012747	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
258594012748	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
258594012749	MarR family; Region: MarR_2; cl17246
258594012750	Transcriptional regulators [Transcription]; Region: MarR; COG1846
258594012751	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
258594012752	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
258594012753	putative substrate binding pocket [chemical binding]; other site
258594012754	trimer interface [polypeptide binding]; other site
258594012755	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
258594012756	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
258594012757	NAD binding site [chemical binding]; other site
258594012758	catalytic residues [active]
258594012759	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
258594012760	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
258594012761	tetramer interface [polypeptide binding]; other site
258594012762	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
258594012763	tetramer interface [polypeptide binding]; other site
258594012764	active site
258594012765	metal binding site [ion binding]; metal-binding site
258594012766	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
258594012767	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
258594012768	hypothetical protein; Provisional; Region: PRK08266
258594012769	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
258594012770	PYR/PP interface [polypeptide binding]; other site
258594012771	dimer interface [polypeptide binding]; other site
258594012772	TPP binding site [chemical binding]; other site
258594012773	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
258594012774	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
258594012775	TPP-binding site [chemical binding]; other site
258594012776	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
258594012777	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
258594012778	FAD binding pocket [chemical binding]; other site
258594012779	FAD binding motif [chemical binding]; other site
258594012780	phosphate binding motif [ion binding]; other site
258594012781	beta-alpha-beta structure motif; other site
258594012782	NAD(p) ribose binding residues [chemical binding]; other site
258594012783	NAD binding pocket [chemical binding]; other site
258594012784	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
258594012785	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
258594012786	catalytic loop [active]
258594012787	iron binding site [ion binding]; other site
258594012788	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
258594012789	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
258594012790	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
258594012791	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
258594012792	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
258594012793	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
258594012794	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594012795	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594012796	Phasin protein; Region: Phasin_2; cl11491
258594012797	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
258594012798	PGAP1-like protein; Region: PGAP1; pfam07819
258594012799	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
258594012800	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
258594012801	hydroxyglutarate oxidase; Provisional; Region: PRK11728
258594012802	1 probable transmembrane helix predicted byTMHMM2.0
258594012803	multidrug efflux protein; Reviewed; Region: PRK09579
258594012804	Protein export membrane protein; Region: SecD_SecF; cl14618
258594012805	10 probable transmembrane helices predicted byTMHMM2.0
258594012806	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594012807	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594012808	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594012809	1 probable transmembrane helix predicted byTMHMM2.0
258594012810	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594012811	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594012812	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
258594012813	Cytochrome P450; Region: p450; cl12078
258594012814	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
258594012815	hypothetical protein; Provisional; Region: PRK12472
258594012816	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
258594012817	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
258594012818	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
258594012819	substrate binding site [chemical binding]; other site
258594012820	ATP binding site [chemical binding]; other site
258594012821	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
258594012822	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
258594012823	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
258594012824	9 probable transmembrane helices predicted byTMHMM2.0
258594012825	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
258594012826	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
258594012827	Ligand binding site; other site
258594012828	Putative Catalytic site; other site
258594012829	DXD motif; other site
258594012830	Predicted membrane protein [Function unknown]; Region: COG2246
258594012831	GtrA-like protein; Region: GtrA; pfam04138
258594012832	4 probable transmembrane helices predicted byTMHMM2.0
258594012833	Protein of unknown function DUF72; Region: DUF72; pfam01904
258594012834	1 probable transmembrane helix predicted byTMHMM2.0
258594012835	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
258594012836	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
258594012837	6 probable transmembrane helices predicted byTMHMM2.0
258594012838	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
258594012839	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
258594012840	Walker A/P-loop; other site
258594012841	ATP binding site [chemical binding]; other site
258594012842	Q-loop/lid; other site
258594012843	ABC transporter signature motif; other site
258594012844	Walker B; other site
258594012845	D-loop; other site
258594012846	H-loop/switch region; other site
258594012847	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594012848	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594012849	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594012850	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594012851	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594012852	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594012853	metal binding site [ion binding]; metal-binding site
258594012854	active site
258594012855	I-site; other site
258594012856	6 probable transmembrane helices predicted byTMHMM2.0
258594012857	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
258594012858	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
258594012859	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594012860	enoyl-CoA hydratase; Provisional; Region: PRK05862
258594012861	substrate binding site [chemical binding]; other site
258594012862	oxyanion hole (OAH) forming residues; other site
258594012863	trimer interface [polypeptide binding]; other site
258594012864	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594012865	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594012866	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
258594012867	dimerization interface [polypeptide binding]; other site
258594012868	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
258594012869	putative MPT binding site; other site
258594012870	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
258594012871	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
258594012872	Ligand binding site; other site
258594012873	metal-binding site
258594012874	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
258594012875	XdhC Rossmann domain; Region: XdhC_C; pfam13478
258594012876	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
258594012877	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
258594012878	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
258594012879	metal ion-dependent adhesion site (MIDAS); other site
258594012880	MoxR-like ATPases [General function prediction only]; Region: COG0714
258594012881	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594012882	Walker A motif; other site
258594012883	ATP binding site [chemical binding]; other site
258594012884	Walker B motif; other site
258594012885	arginine finger; other site
258594012886	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
258594012887	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
258594012888	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
258594012889	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
258594012890	catalytic loop [active]
258594012891	iron binding site [ion binding]; other site
258594012892	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
258594012893	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
258594012894	putative hydrophobic ligand binding site [chemical binding]; other site
258594012895	3 probable transmembrane helices predicted byTMHMM2.0
258594012896	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594012897	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594012898	TM-ABC transporter signature motif; other site
258594012899	8 probable transmembrane helices predicted byTMHMM2.0
258594012900	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
258594012901	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
258594012902	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594012903	TM-ABC transporter signature motif; other site
258594012904	12 probable transmembrane helices predicted byTMHMM2.0
258594012905	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594012906	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594012907	Walker A/P-loop; other site
258594012908	ATP binding site [chemical binding]; other site
258594012909	Q-loop/lid; other site
258594012910	ABC transporter signature motif; other site
258594012911	Walker B; other site
258594012912	D-loop; other site
258594012913	H-loop/switch region; other site
258594012914	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594012915	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594012916	Walker A/P-loop; other site
258594012917	ATP binding site [chemical binding]; other site
258594012918	Q-loop/lid; other site
258594012919	ABC transporter signature motif; other site
258594012920	Walker B; other site
258594012921	D-loop; other site
258594012922	H-loop/switch region; other site
258594012923	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
258594012924	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
258594012925	dimerization interface [polypeptide binding]; other site
258594012926	ligand binding site [chemical binding]; other site
258594012927	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
258594012928	GIY-YIG motif/motif A; other site
258594012929	putative active site [active]
258594012930	putative metal binding site [ion binding]; other site
258594012931	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
258594012932	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
258594012933	6 probable transmembrane helices predicted byTMHMM2.0
258594012934	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
258594012935	putative active site pocket [active]
258594012936	cleavage site
258594012937	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
258594012938	EF-hand domain pair; Region: EF_hand_5; pfam13499
258594012939	Ca2+ binding site [ion binding]; other site
258594012940	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
258594012941	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
258594012942	substrate binding site [chemical binding]; other site
258594012943	hexamer interface [polypeptide binding]; other site
258594012944	metal binding site [ion binding]; metal-binding site
258594012945	adenylosuccinate lyase; Provisional; Region: PRK07492
258594012946	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
258594012947	tetramer interface [polypeptide binding]; other site
258594012948	active site
258594012949	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
258594012950	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
258594012951	putative active site [active]
258594012952	catalytic triad [active]
258594012953	ORF6C domain; Region: ORF6C; pfam10552
258594012954	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
258594012955	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
258594012956	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
258594012957	ATP binding site [chemical binding]; other site
258594012958	active site
258594012959	substrate binding site [chemical binding]; other site
258594012960	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
258594012961	Trp repressor protein; Region: Trp_repressor; cl17266
258594012962	Helix-turn-helix domain; Region: HTH_37; pfam13744
258594012963	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
258594012964	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
258594012965	tetramer interface [polypeptide binding]; other site
258594012966	active site
258594012967	Mg2+/Mn2+ binding site [ion binding]; other site
258594012968	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
258594012969	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594012970	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
258594012971	sequence-specific DNA binding site [nucleotide binding]; other site
258594012972	salt bridge; other site
258594012973	transcription elongation factor regulatory protein; Validated; Region: PRK06342
258594012974	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
258594012975	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
258594012976	active site
258594012977	SUMO-1 interface [polypeptide binding]; other site
258594012978	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
258594012979	PAS domain S-box; Region: sensory_box; TIGR00229
258594012980	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594012981	putative active site [active]
258594012982	heme pocket [chemical binding]; other site
258594012983	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594012984	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594012985	metal binding site [ion binding]; metal-binding site
258594012986	active site
258594012987	I-site; other site
258594012988	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
258594012989	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
258594012990	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
258594012991	putative active site [active]
258594012992	isocitrate dehydrogenase; Validated; Region: PRK08299
258594012993	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
258594012994	ISR1-like IS element
258594012995	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
258594012996	HTH-like domain; Region: HTH_21; pfam13276
258594012997	Integrase core domain; Region: rve; pfam00665
258594012998	Integrase core domain; Region: rve_3; pfam13683
258594012999	Transposase; Region: HTH_Tnp_1; pfam01527
258594013000	Uncharacterized conserved protein [Function unknown]; Region: COG1742
258594013001	4 probable transmembrane helices predicted byTMHMM2.0
258594013002	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
258594013003	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594013004	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
258594013005	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594013006	N-terminal plug; other site
258594013007	ligand-binding site [chemical binding]; other site
258594013008	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
258594013009	4 probable transmembrane helices predicted byTMHMM2.0
258594013010	putative cation:proton antiport protein; Provisional; Region: PRK10669
258594013011	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
258594013012	TrkA-N domain; Region: TrkA_N; pfam02254
258594013013	12 probable transmembrane helices predicted byTMHMM2.0
258594013014	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
258594013015	TrkA-N domain; Region: TrkA_N; pfam02254
258594013016	10 probable transmembrane helices predicted byTMHMM2.0
258594013017	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
258594013018	Domain of unknown function DUF20; Region: UPF0118; pfam01594
258594013019	8 probable transmembrane helices predicted byTMHMM2.0
258594013020	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594013021	Coenzyme A binding pocket [chemical binding]; other site
258594013022	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
258594013023	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
258594013024	motif 1; other site
258594013025	active site
258594013026	motif 2; other site
258594013027	motif 3; other site
258594013028	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
258594013029	DHHA1 domain; Region: DHHA1; pfam02272
258594013030	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
258594013031	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
258594013032	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
258594013033	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
258594013034	lipoyl attachment site [posttranslational modification]; other site
258594013035	glycine dehydrogenase; Provisional; Region: PRK05367
258594013036	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
258594013037	tetramer interface [polypeptide binding]; other site
258594013038	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594013039	catalytic residue [active]
258594013040	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
258594013041	tetramer interface [polypeptide binding]; other site
258594013042	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594013043	catalytic residue [active]
258594013044	recombinase A; Provisional; Region: recA; PRK09354
258594013045	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
258594013046	hexamer interface [polypeptide binding]; other site
258594013047	Walker A motif; other site
258594013048	ATP binding site [chemical binding]; other site
258594013049	Walker B motif; other site
258594013050	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
258594013051	Helix-turn-helix domain; Region: HTH_28; pfam13518
258594013052	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
258594013053	active site
258594013054	catalytic triad [active]
258594013055	oxyanion hole [active]
258594013056	Autotransporter beta-domain; Region: Autotransporter; smart00869
258594013057	2 probable transmembrane helices predicted byTMHMM2.0
258594013058	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
258594013059	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594013060	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
258594013061	ligand binding site [chemical binding]; other site
258594013062	flexible hinge region; other site
258594013063	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
258594013064	non-specific DNA interactions [nucleotide binding]; other site
258594013065	DNA binding site [nucleotide binding]
258594013066	sequence specific DNA binding site [nucleotide binding]; other site
258594013067	putative cAMP binding site [chemical binding]; other site
258594013068	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
258594013069	CoenzymeA binding site [chemical binding]; other site
258594013070	subunit interaction site [polypeptide binding]; other site
258594013071	PHB binding site; other site
258594013072	Caspase domain; Region: Peptidase_C14; pfam00656
258594013073	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
258594013074	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
258594013075	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
258594013076	catalytic residues [active]
258594013077	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594013078	sequence-specific DNA binding site [nucleotide binding]; other site
258594013079	salt bridge; other site
258594013080	4 probable transmembrane helices predicted byTMHMM2.0
258594013081	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
258594013082	Intracellular septation protein A; Region: IspA; cl01098
258594013083	5 probable transmembrane helices predicted byTMHMM2.0
258594013084	fumarate hydratase; Provisional; Region: PRK15389
258594013085	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
258594013086	Fumarase C-terminus; Region: Fumerase_C; pfam05683
258594013087	Uncharacterized conserved protein [Function unknown]; Region: COG3791
258594013088	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
258594013089	glutathione s-transferase; Provisional; Region: PTZ00057
258594013090	GSH binding site (G-site) [chemical binding]; other site
258594013091	C-terminal domain interface [polypeptide binding]; other site
258594013092	dimer interface [polypeptide binding]; other site
258594013093	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
258594013094	dimer interface [polypeptide binding]; other site
258594013095	N-terminal domain interface [polypeptide binding]; other site
258594013096	substrate binding pocket (H-site) [chemical binding]; other site
258594013097	Tim44-like domain; Region: Tim44; pfam04280
258594013098	3 probable transmembrane helices predicted byTMHMM2.0
258594013099	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594013100	PAS domain; Region: PAS_9; pfam13426
258594013101	putative active site [active]
258594013102	heme pocket [chemical binding]; other site
258594013103	PAS fold; Region: PAS_4; pfam08448
258594013104	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594013105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594013106	dimer interface [polypeptide binding]; other site
258594013107	phosphorylation site [posttranslational modification]
258594013108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594013109	ATP binding site [chemical binding]; other site
258594013110	Mg2+ binding site [ion binding]; other site
258594013111	G-X-G motif; other site
258594013112	Response regulator receiver domain; Region: Response_reg; pfam00072
258594013113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594013114	active site
258594013115	phosphorylation site [posttranslational modification]
258594013116	intermolecular recognition site; other site
258594013117	dimerization interface [polypeptide binding]; other site
258594013118	2 probable transmembrane helices predicted byTMHMM2.0
258594013119	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
258594013120	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
258594013121	4 probable transmembrane helices predicted byTMHMM2.0
258594013122	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
258594013123	7 probable transmembrane helices predicted byTMHMM2.0
258594013124	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
258594013125	2 probable transmembrane helices predicted byTMHMM2.0
258594013126	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00732
258594013127	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
258594013128	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
258594013129	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
258594013130	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
258594013131	1 probable transmembrane helix predicted byTMHMM2.0
258594013132	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
258594013133	5 probable transmembrane helices predicted byTMHMM2.0
258594013134	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
258594013135	1 probable transmembrane helix predicted byTMHMM2.0
258594013136	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
258594013137	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
258594013138	substrate binding pocket [chemical binding]; other site
258594013139	catalytic triad [active]
258594013140	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594013141	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594013142	Uncharacterized conserved protein [Function unknown]; Region: COG3334
258594013143	1 probable transmembrane helix predicted byTMHMM2.0
258594013144	1 probable transmembrane helix predicted byTMHMM2.0
258594013145	flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795
258594013146	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
258594013147	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785
258594013148	1 probable transmembrane helix predicted byTMHMM2.0
258594013149	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689
258594013150	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
258594013151	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
258594013152	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
258594013153	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
258594013154	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786
258594013155	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
258594013156	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
258594013157	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
258594013158	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
258594013159	Protein export membrane protein; Region: SecD_SecF; cl14618
258594013160	11 probable transmembrane helices predicted byTMHMM2.0
258594013161	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594013162	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594013163	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594013164	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
258594013165	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
258594013166	flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787
258594013167	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
258594013168	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
258594013169	1 probable transmembrane helix predicted byTMHMM2.0
258594013170	chemotactic signal-response protein CheL; Provisional; Region: PRK12790
258594013171	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794
258594013172	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK12791
258594013173	flagellin; Provisional; Region: PRK14708
258594013174	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
258594013175	Domain of Unknown Function (DUF1522); Region: DUF1522; pfam07482
258594013176	Domain of Unknown Function (DUF1522); Region: DUF1522; pfam07482
258594013177	Tetratricopeptide repeat; Region: TPR_2; pfam07719
258594013178	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
258594013179	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594013180	binding surface
258594013181	TPR motif; other site
258594013182	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
258594013183	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594013184	binding surface
258594013185	TPR motif; other site
258594013186	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594013187	binding surface
258594013188	TPR motif; other site
258594013189	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
258594013190	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
258594013191	PYR/PP interface [polypeptide binding]; other site
258594013192	dimer interface [polypeptide binding]; other site
258594013193	TPP binding site [chemical binding]; other site
258594013194	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
258594013195	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
258594013196	TPP-binding site [chemical binding]; other site
258594013197	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594013198	NAD(P) binding site [chemical binding]; other site
258594013199	active site
258594013200	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
258594013201	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
258594013202	active site
258594013203	Substrate binding site; other site
258594013204	Mg++ binding site; other site
258594013205	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
258594013206	active site
258594013207	nucleotide binding site [chemical binding]; other site
258594013208	HIGH motif; other site
258594013209	KMSKS motif; other site
258594013210	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
258594013211	putative ribose interaction site [chemical binding]; other site
258594013212	putative ADP binding site [chemical binding]; other site
258594013213	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
258594013214	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
258594013215	NAD(P) binding site [chemical binding]; other site
258594013216	2 probable transmembrane helices predicted byTMHMM2.0
258594013217	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
258594013218	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
258594013219	alpha subunit interface [polypeptide binding]; other site
258594013220	TPP binding site [chemical binding]; other site
258594013221	heterodimer interface [polypeptide binding]; other site
258594013222	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
258594013223	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
258594013224	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
258594013225	tetramer interface [polypeptide binding]; other site
258594013226	TPP-binding site [chemical binding]; other site
258594013227	heterodimer interface [polypeptide binding]; other site
258594013228	phosphorylation loop region [posttranslational modification]
258594013229	Methyltransferase domain; Region: Methyltransf_31; pfam13847
258594013230	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594013231	S-adenosylmethionine binding site [chemical binding]; other site
258594013232	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
258594013233	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594013234	NAD(P) binding site [chemical binding]; other site
258594013235	active site
258594013236	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
258594013237	extended (e) SDRs; Region: SDR_e; cd08946
258594013238	NAD(P) binding site [chemical binding]; other site
258594013239	active site
258594013240	substrate binding site [chemical binding]; other site
258594013241	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594013242	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
258594013243	dimer interface [polypeptide binding]; other site
258594013244	active site
258594013245	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
258594013246	flagellin; Provisional; Region: PRK14708
258594013247	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
258594013248	Domain of Unknown Function (DUF1522); Region: DUF1522; pfam07482
258594013249	Domain of Unknown Function (DUF1522); Region: DUF1522; pfam07482
258594013250	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
258594013251	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
258594013252	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
258594013253	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
258594013254	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
258594013255	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
258594013256	PAS fold; Region: PAS_4; pfam08448
258594013257	GAF domain; Region: GAF; cl17456
258594013258	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594013259	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594013260	dimer interface [polypeptide binding]; other site
258594013261	phosphorylation site [posttranslational modification]
258594013262	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594013263	ATP binding site [chemical binding]; other site
258594013264	Mg2+ binding site [ion binding]; other site
258594013265	G-X-G motif; other site
258594013266	Response regulator receiver domain; Region: Response_reg; pfam00072
258594013267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594013268	active site
258594013269	phosphorylation site [posttranslational modification]
258594013270	intermolecular recognition site; other site
258594013271	dimerization interface [polypeptide binding]; other site
258594013272	PAS fold; Region: PAS_4; pfam08448
258594013273	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594013274	putative active site [active]
258594013275	heme pocket [chemical binding]; other site
258594013276	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594013277	dimer interface [polypeptide binding]; other site
258594013278	phosphorylation site [posttranslational modification]
258594013279	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594013280	ATP binding site [chemical binding]; other site
258594013281	Mg2+ binding site [ion binding]; other site
258594013282	G-X-G motif; other site
258594013283	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
258594013284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594013285	active site
258594013286	phosphorylation site [posttranslational modification]
258594013287	intermolecular recognition site; other site
258594013288	dimerization interface [polypeptide binding]; other site
258594013289	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
258594013290	9 probable transmembrane helices predicted byTMHMM2.0
258594013291	methionine sulfoxide reductase B; Provisional; Region: PRK00222
258594013292	SelR domain; Region: SelR; pfam01641
258594013293	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
258594013294	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
258594013295	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
258594013296	catalytic core [active]
258594013297	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
258594013298	Ligand Binding Site [chemical binding]; other site
258594013299	2 probable transmembrane helices predicted byTMHMM2.0
258594013300	4 probable transmembrane helices predicted byTMHMM2.0
258594013301	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
258594013302	dimerization interface [polypeptide binding]; other site
258594013303	metal binding site [ion binding]; metal-binding site
258594013304	Predicted integral membrane protein [Function unknown]; Region: COG0392
258594013305	8 probable transmembrane helices predicted byTMHMM2.0
258594013306	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
258594013307	oxyanion hole [active]
258594013308	1 probable transmembrane helix predicted byTMHMM2.0
258594013309	Protein of unknown function (DUF2806); Region: DUF2806; pfam10987
258594013310	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
258594013311	1 probable transmembrane helix predicted byTMHMM2.0
258594013312	12 probable transmembrane helices predicted byTMHMM2.0
258594013313	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
258594013314	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
258594013315	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
258594013316	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
258594013317	active site
258594013318	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
258594013319	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
258594013320	NADP-binding site; other site
258594013321	homotetramer interface [polypeptide binding]; other site
258594013322	substrate binding site [chemical binding]; other site
258594013323	homodimer interface [polypeptide binding]; other site
258594013324	active site
258594013325	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594013326	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
258594013327	NAD(P) binding site [chemical binding]; other site
258594013328	active site
258594013329	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
258594013330	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
258594013331	putative ion selectivity filter; other site
258594013332	putative pore gating glutamate residue; other site
258594013333	putative H+/Cl- coupling transport residue; other site
258594013334	10 probable transmembrane helices predicted byTMHMM2.0
258594013335	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
258594013336	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
258594013337	1 probable transmembrane helix predicted byTMHMM2.0
258594013338	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
258594013339	active site
258594013340	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
258594013341	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
258594013342	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323
258594013343	2 probable transmembrane helices predicted byTMHMM2.0
258594013344	amidase; Provisional; Region: PRK07869
258594013345	Amidase; Region: Amidase; cl11426
258594013346	Uncharacterized conserved protein [Function unknown]; Region: COG1432
258594013347	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
258594013348	putative metal binding site [ion binding]; other site
258594013349	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
258594013350	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
258594013351	mce related protein; Region: MCE; pfam02470
258594013352	1 probable transmembrane helix predicted byTMHMM2.0
258594013353	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
258594013354	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
258594013355	Walker A/P-loop; other site
258594013356	ATP binding site [chemical binding]; other site
258594013357	Q-loop/lid; other site
258594013358	ABC transporter signature motif; other site
258594013359	Walker B; other site
258594013360	D-loop; other site
258594013361	H-loop/switch region; other site
258594013362	STAS domain; Region: STAS_2; pfam13466
258594013363	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
258594013364	Permease; Region: Permease; pfam02405
258594013365	6 probable transmembrane helices predicted byTMHMM2.0
258594013366	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
258594013367	active site
258594013368	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
258594013369	12 probable transmembrane helices predicted byTMHMM2.0
258594013370	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
258594013371	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
258594013372	tetramer interface [polypeptide binding]; other site
258594013373	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594013374	catalytic residue [active]
258594013375	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
258594013376	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
258594013377	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
258594013378	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
258594013379	putative active site [active]
258594013380	putative metal binding site [ion binding]; other site
258594013381	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594013382	S-adenosylmethionine binding site [chemical binding]; other site
258594013383	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
258594013384	dimer interface [polypeptide binding]; other site
258594013385	substrate binding site [chemical binding]; other site
258594013386	ATP binding site [chemical binding]; other site
258594013387	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
258594013388	Cytochrome c; Region: Cytochrom_C; pfam00034
258594013389	1 probable transmembrane helix predicted byTMHMM2.0
258594013390	Cytochrome C' Region: Cytochrom_C_2; pfam01322
258594013391	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
258594013392	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
258594013393	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
258594013394	1 probable transmembrane helix predicted byTMHMM2.0
258594013395	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
258594013396	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
258594013397	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
258594013398	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
258594013399	11 probable transmembrane helices predicted byTMHMM2.0
258594013400	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
258594013401	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
258594013402	inhibitor-cofactor binding pocket; inhibition site
258594013403	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594013404	catalytic residue [active]
258594013405	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
258594013406	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
258594013407	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
258594013408	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
258594013409	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
258594013410	putative NAD(P) binding site [chemical binding]; other site
258594013411	active site
258594013412	putative substrate binding site [chemical binding]; other site
258594013413	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
258594013414	8 probable transmembrane helices predicted byTMHMM2.0
258594013415	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
258594013416	Mg++ binding site [ion binding]; other site
258594013417	putative catalytic motif [active]
258594013418	putative substrate binding site [chemical binding]; other site
258594013419	11 probable transmembrane helices predicted byTMHMM2.0
258594013420	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
258594013421	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
258594013422	NAD(P) binding site [chemical binding]; other site
258594013423	homodimer interface [polypeptide binding]; other site
258594013424	substrate binding site [chemical binding]; other site
258594013425	active site
258594013426	4 probable transmembrane helices predicted byTMHMM2.0
258594013427	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
258594013428	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
258594013429	putative ribose interaction site [chemical binding]; other site
258594013430	putative ADP binding site [chemical binding]; other site
258594013431	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
258594013432	active site
258594013433	nucleotide binding site [chemical binding]; other site
258594013434	HIGH motif; other site
258594013435	KMSKS motif; other site
258594013436	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
258594013437	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
258594013438	NADP binding site [chemical binding]; other site
258594013439	homopentamer interface [polypeptide binding]; other site
258594013440	substrate binding site [chemical binding]; other site
258594013441	active site
258594013442	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
258594013443	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
258594013444	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
258594013445	putative active site [active]
258594013446	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
258594013447	active site
258594013448	dimer interface [polypeptide binding]; other site
258594013449	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
258594013450	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594013451	active site
258594013452	motif I; other site
258594013453	motif II; other site
258594013454	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
258594013455	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
258594013456	putative active site [active]
258594013457	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
258594013458	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
258594013459	NAD binding site [chemical binding]; other site
258594013460	homodimer interface [polypeptide binding]; other site
258594013461	active site
258594013462	substrate binding site [chemical binding]; other site
258594013463	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
258594013464	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
258594013465	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
258594013466	Walker A/P-loop; other site
258594013467	ATP binding site [chemical binding]; other site
258594013468	Q-loop/lid; other site
258594013469	ABC transporter signature motif; other site
258594013470	Walker B; other site
258594013471	D-loop; other site
258594013472	H-loop/switch region; other site
258594013473	3 probable transmembrane helices predicted byTMHMM2.0
258594013474	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
258594013475	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
258594013476	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
258594013477	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594013478	NAD(P) binding site [chemical binding]; other site
258594013479	active site
258594013480	PAS fold; Region: PAS_7; pfam12860
258594013481	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594013482	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594013483	metal binding site [ion binding]; metal-binding site
258594013484	active site
258594013485	I-site; other site
258594013486	4 probable transmembrane helices predicted byTMHMM2.0
258594013487	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594013488	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594013489	ligand binding site [chemical binding]; other site
258594013490	flexible hinge region; other site
258594013491	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
258594013492	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
258594013493	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594013494	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
258594013495	FeS/SAM binding site; other site
258594013496	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
258594013497	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
258594013498	Double zinc ribbon; Region: DZR; pfam12773
258594013499	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
258594013500	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
258594013501	cyclase homology domain; Region: CHD; cd07302
258594013502	nucleotidyl binding site; other site
258594013503	metal binding site [ion binding]; metal-binding site
258594013504	dimer interface [polypeptide binding]; other site
258594013505	Predicted ATPase [General function prediction only]; Region: COG3899
258594013506	AAA ATPase domain; Region: AAA_16; pfam13191
258594013507	Predicted ATPase [General function prediction only]; Region: COG3903
258594013508	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
258594013509	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
258594013510	ATP binding site [chemical binding]; other site
258594013511	putative Mg++ binding site [ion binding]; other site
258594013512	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
258594013513	nucleotide binding region [chemical binding]; other site
258594013514	ATP-binding site [chemical binding]; other site
258594013515	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
258594013516	RNA binding site [nucleotide binding]; other site
258594013517	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594013518	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594013519	active site
258594013520	possible ribosomal protein S21
258594013521	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
258594013522	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
258594013523	GAF domain; Region: GAF; pfam01590
258594013524	GAF domain; Region: GAF; pfam01590
258594013525	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
258594013526	HWE histidine kinase; Region: HWE_HK; smart00911
258594013527	Response regulator receiver domain; Region: Response_reg; pfam00072
258594013528	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594013529	active site
258594013530	phosphorylation site [posttranslational modification]
258594013531	intermolecular recognition site; other site
258594013532	dimerization interface [polypeptide binding]; other site
258594013533	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
258594013534	catalytic triad [active]
258594013535	putative active site [active]
258594013536	Autotransporter beta-domain; Region: Autotransporter; smart00869
258594013537	Predicted transcriptional regulator [Transcription]; Region: COG2378
258594013538	HTH domain; Region: HTH_11; pfam08279
258594013539	WYL domain; Region: WYL; pfam13280
258594013540	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
258594013541	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594013542	Walker A/P-loop; other site
258594013543	ATP binding site [chemical binding]; other site
258594013544	Q-loop/lid; other site
258594013545	ABC transporter signature motif; other site
258594013546	Walker B; other site
258594013547	D-loop; other site
258594013548	H-loop/switch region; other site
258594013549	ABC transporter; Region: ABC_tran_2; pfam12848
258594013550	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
258594013551	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
258594013552	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
258594013553	homotetramer interface [polypeptide binding]; other site
258594013554	ligand binding site [chemical binding]; other site
258594013555	catalytic site [active]
258594013556	NAD binding site [chemical binding]; other site
258594013557	S-adenosylmethionine synthetase; Validated; Region: PRK05250
258594013558	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
258594013559	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
258594013560	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
258594013561	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
258594013562	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
258594013563	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
258594013564	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
258594013565	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
258594013566	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
258594013567	putative ligand binding site [chemical binding]; other site
258594013568	1 probable transmembrane helix predicted byTMHMM2.0
258594013569	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594013570	TM-ABC transporter signature motif; other site
258594013571	8 probable transmembrane helices predicted byTMHMM2.0
258594013572	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594013573	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594013574	TM-ABC transporter signature motif; other site
258594013575	9 probable transmembrane helices predicted byTMHMM2.0
258594013576	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594013577	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594013578	Walker A/P-loop; other site
258594013579	ATP binding site [chemical binding]; other site
258594013580	Q-loop/lid; other site
258594013581	ABC transporter signature motif; other site
258594013582	Walker B; other site
258594013583	D-loop; other site
258594013584	H-loop/switch region; other site
258594013585	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594013586	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594013587	Walker A/P-loop; other site
258594013588	ATP binding site [chemical binding]; other site
258594013589	Q-loop/lid; other site
258594013590	ABC transporter signature motif; other site
258594013591	Walker B; other site
258594013592	D-loop; other site
258594013593	H-loop/switch region; other site
258594013594	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
258594013595	substrate binding site [chemical binding]; other site
258594013596	THF binding site; other site
258594013597	zinc-binding site [ion binding]; other site
258594013598	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594013599	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594013600	Walker A/P-loop; other site
258594013601	ATP binding site [chemical binding]; other site
258594013602	Q-loop/lid; other site
258594013603	ABC transporter signature motif; other site
258594013604	Walker B; other site
258594013605	D-loop; other site
258594013606	H-loop/switch region; other site
258594013607	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594013608	ABC transporter; Region: ABC_tran; pfam00005
258594013609	Q-loop/lid; other site
258594013610	ABC transporter signature motif; other site
258594013611	Walker B; other site
258594013612	D-loop; other site
258594013613	H-loop/switch region; other site
258594013614	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594013615	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594013616	TM-ABC transporter signature motif; other site
258594013617	7 probable transmembrane helices predicted byTMHMM2.0
258594013618	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594013619	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594013620	TM-ABC transporter signature motif; other site
258594013621	8 probable transmembrane helices predicted byTMHMM2.0
258594013622	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594013623	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
258594013624	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
258594013625	1 probable transmembrane helix predicted byTMHMM2.0
258594013626	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
258594013627	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
258594013628	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
258594013629	putative active site [active]
258594013630	putative substrate binding site [chemical binding]; other site
258594013631	putative cosubstrate binding site; other site
258594013632	catalytic site [active]
258594013633	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
258594013634	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
258594013635	active site
258594013636	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594013637	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
258594013638	putative ligand binding site [chemical binding]; other site
258594013639	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594013640	TM-ABC transporter signature motif; other site
258594013641	8 probable transmembrane helices predicted byTMHMM2.0
258594013642	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594013643	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594013644	TM-ABC transporter signature motif; other site
258594013645	11 probable transmembrane helices predicted byTMHMM2.0
258594013646	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594013647	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594013648	Walker A/P-loop; other site
258594013649	ATP binding site [chemical binding]; other site
258594013650	Q-loop/lid; other site
258594013651	ABC transporter signature motif; other site
258594013652	Walker B; other site
258594013653	D-loop; other site
258594013654	H-loop/switch region; other site
258594013655	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594013656	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594013657	Walker A/P-loop; other site
258594013658	ATP binding site [chemical binding]; other site
258594013659	Q-loop/lid; other site
258594013660	ABC transporter signature motif; other site
258594013661	Walker B; other site
258594013662	D-loop; other site
258594013663	H-loop/switch region; other site
258594013664	5 probable transmembrane helices predicted byTMHMM2.0
258594013665	10 probable transmembrane helices predicted byTMHMM2.0
258594013666	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594013667	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594013668	Walker A/P-loop; other site
258594013669	ATP binding site [chemical binding]; other site
258594013670	Q-loop/lid; other site
258594013671	ABC transporter signature motif; other site
258594013672	Walker B; other site
258594013673	D-loop; other site
258594013674	H-loop/switch region; other site
258594013675	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
258594013676	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
258594013677	acyl-activating enzyme (AAE) consensus motif; other site
258594013678	putative AMP binding site [chemical binding]; other site
258594013679	putative active site [active]
258594013680	putative CoA binding site [chemical binding]; other site
258594013681	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594013682	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594013683	TM-ABC transporter signature motif; other site
258594013684	8 probable transmembrane helices predicted byTMHMM2.0
258594013685	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594013686	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594013687	TM-ABC transporter signature motif; other site
258594013688	8 probable transmembrane helices predicted byTMHMM2.0
258594013689	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594013690	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
258594013691	putative ligand binding site [chemical binding]; other site
258594013692	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594013693	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594013694	Walker A/P-loop; other site
258594013695	ATP binding site [chemical binding]; other site
258594013696	Q-loop/lid; other site
258594013697	ABC transporter signature motif; other site
258594013698	Walker B; other site
258594013699	D-loop; other site
258594013700	H-loop/switch region; other site
258594013701	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
258594013702	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594013703	motif II; other site
258594013704	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
258594013705	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
258594013706	substrate binding site; other site
258594013707	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
258594013708	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
258594013709	NAD binding site [chemical binding]; other site
258594013710	homotetramer interface [polypeptide binding]; other site
258594013711	homodimer interface [polypeptide binding]; other site
258594013712	substrate binding site [chemical binding]; other site
258594013713	active site
258594013714	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
258594013715	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
258594013716	classical (c) SDRs; Region: SDR_c; cd05233
258594013717	NAD(P) binding site [chemical binding]; other site
258594013718	active site
258594013719	Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like1; cd08196
258594013720	putative active site [active]
258594013721	metal binding site [ion binding]; metal-binding site
258594013722	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594013723	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
258594013724	NAD(P) binding site [chemical binding]; other site
258594013725	active site
258594013726	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
258594013727	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
258594013728	PYR/PP interface [polypeptide binding]; other site
258594013729	dimer interface [polypeptide binding]; other site
258594013730	TPP binding site [chemical binding]; other site
258594013731	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
258594013732	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
258594013733	TPP-binding site [chemical binding]; other site
258594013734	Predicted membrane protein [Function unknown]; Region: COG2246
258594013735	GtrA-like protein; Region: GtrA; pfam04138
258594013736	4 probable transmembrane helices predicted byTMHMM2.0
258594013737	Methyltransferase domain; Region: Methyltransf_23; pfam13489
258594013738	Methyltransferase domain; Region: Methyltransf_12; pfam08242
258594013739	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
258594013740	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
258594013741	Ligand binding site; other site
258594013742	Putative Catalytic site; other site
258594013743	DXD motif; other site
258594013744	2 probable transmembrane helices predicted byTMHMM2.0
258594013745	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
258594013746	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
258594013747	active site
258594013748	2 probable transmembrane helices predicted byTMHMM2.0
258594013749	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
258594013750	8 probable transmembrane helices predicted byTMHMM2.0
258594013751	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
258594013752	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
258594013753	Probable Catalytic site; other site
258594013754	12 probable transmembrane helices predicted byTMHMM2.0
258594013755	14 probable transmembrane helices predicted byTMHMM2.0
258594013756	19 probable transmembrane helices predicted byTMHMM2.0
258594013757	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
258594013758	13 probable transmembrane helices predicted byTMHMM2.0
258594013759	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
258594013760	methionine sulfoxide reductase B; Provisional; Region: PRK00222
258594013761	SelR domain; Region: SelR; pfam01641
258594013762	methionine sulfoxide reductase A; Provisional; Region: PRK13014
258594013763	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
258594013764	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
258594013765	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
258594013766	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
258594013767	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
258594013768	ATP-grasp domain; Region: ATP-grasp_4; cl17255
258594013769	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
258594013770	IMP binding site; other site
258594013771	dimer interface [polypeptide binding]; other site
258594013772	interdomain contacts; other site
258594013773	partial ornithine binding site; other site
258594013774	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
258594013775	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
258594013776	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
258594013777	Predicted membrane protein [Function unknown]; Region: COG2259
258594013778	4 probable transmembrane helices predicted byTMHMM2.0
258594013779	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
258594013780	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594013781	putative DNA binding site [nucleotide binding]; other site
258594013782	putative Zn2+ binding site [ion binding]; other site
258594013783	AsnC family; Region: AsnC_trans_reg; pfam01037
258594013784	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
258594013785	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
258594013786	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
258594013787	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594013788	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594013789	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
258594013790	putative effector binding pocket; other site
258594013791	dimerization interface [polypeptide binding]; other site
258594013792	AAA domain; Region: AAA_31; pfam13614
258594013793	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
258594013794	P-loop; other site
258594013795	Magnesium ion binding site [ion binding]; other site
258594013796	1 probable transmembrane helix predicted byTMHMM2.0
258594013797	1 probable transmembrane helix predicted byTMHMM2.0
258594013798	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
258594013799	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
258594013800	1 probable transmembrane helix predicted byTMHMM2.0
258594013801	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
258594013802	active site
258594013803	Int/Topo IB signature motif; other site
258594013804	IS element
258594013805	6 probable transmembrane helices predicted byTMHMM2.0
258594013806	Cell division protein 48 (CDC48), domain 2; Region: CDC48_2; pfam02933
258594013807	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594013808	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
258594013809	Walker A motif; other site
258594013810	ATP binding site [chemical binding]; other site
258594013811	Walker B motif; other site
258594013812	arginine finger; other site
258594013813	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594013814	Walker B motif; other site
258594013815	arginine finger; other site
258594013816	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594013817	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594013818	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
258594013819	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
258594013820	6 probable transmembrane helices predicted byTMHMM2.0
258594013821	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
258594013822	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
258594013823	Walker A/P-loop; other site
258594013824	ATP binding site [chemical binding]; other site
258594013825	Q-loop/lid; other site
258594013826	ABC transporter signature motif; other site
258594013827	Walker B; other site
258594013828	D-loop; other site
258594013829	H-loop/switch region; other site
258594013830	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594013831	Walker A/P-loop; other site
258594013832	ATP binding site [chemical binding]; other site
258594013833	Q-loop/lid; other site
258594013834	ABC transporter signature motif; other site
258594013835	Walker B; other site
258594013836	D-loop; other site
258594013837	H-loop/switch region; other site
258594013838	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
258594013839	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
258594013840	5 probable transmembrane helices predicted byTMHMM2.0
258594013841	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
258594013842	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594013843	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594013844	1 probable transmembrane helix predicted byTMHMM2.0
258594013845	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
258594013846	active site
258594013847	nucleophile elbow; other site
258594013848	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
258594013849	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
258594013850	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
258594013851	Ligand Binding Site [chemical binding]; other site
258594013852	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
258594013853	Ligand Binding Site [chemical binding]; other site
258594013854	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
258594013855	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
258594013856	Protein export membrane protein; Region: SecD_SecF; cl14618
258594013857	12 probable transmembrane helices predicted byTMHMM2.0
258594013858	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594013859	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594013860	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594013861	1 probable transmembrane helix predicted byTMHMM2.0
258594013862	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594013863	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594013864	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
258594013865	4 probable transmembrane helices predicted byTMHMM2.0
258594013866	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
258594013867	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
258594013868	MarR family; Region: MarR; pfam01047
258594013869	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
258594013870	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
258594013871	putative C-terminal domain interface [polypeptide binding]; other site
258594013872	putative GSH binding site (G-site) [chemical binding]; other site
258594013873	putative dimer interface [polypeptide binding]; other site
258594013874	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
258594013875	putative N-terminal domain interface [polypeptide binding]; other site
258594013876	putative dimer interface [polypeptide binding]; other site
258594013877	putative substrate binding pocket (H-site) [chemical binding]; other site
258594013878	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
258594013879	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594013880	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594013881	1 probable transmembrane helix predicted byTMHMM2.0
258594013882	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
258594013883	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594013884	putative substrate translocation pore; other site
258594013885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594013886	13 probable transmembrane helices predicted byTMHMM2.0
258594013887	Outer membrane efflux protein; Region: OEP; pfam02321
258594013888	Outer membrane efflux protein; Region: OEP; pfam02321
258594013889	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594013890	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594013891	myosin-cross-reactive antigen; Provisional; Region: PRK13977
258594013892	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594013893	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594013894	metal binding site [ion binding]; metal-binding site
258594013895	active site
258594013896	I-site; other site
258594013897	Type II/IV secretion system protein; Region: T2SE; pfam00437
258594013898	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
258594013899	Walker A motif; other site
258594013900	ATP binding site [chemical binding]; other site
258594013901	Walker B motif; other site
258594013902	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
258594013903	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594013904	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
258594013905	dimerization interface [polypeptide binding]; other site
258594013906	substrate binding pocket [chemical binding]; other site
258594013907	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
258594013908	1 probable transmembrane helix predicted byTMHMM2.0
258594013909	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
258594013910	VirB7 interaction site; other site
258594013911	conjugal transfer protein TrbF; Provisional; Region: PRK13872
258594013912	conjugal transfer protein TrbL; Provisional; Region: PRK13875
258594013913	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
258594013914	6 probable transmembrane helices predicted byTMHMM2.0
258594013915	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
258594013916	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
258594013917	1 probable transmembrane helix predicted byTMHMM2.0
258594013918	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
258594013919	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
258594013920	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594013921	Walker A/P-loop; other site
258594013922	ATP binding site [chemical binding]; other site
258594013923	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594013924	Walker B; other site
258594013925	D-loop; other site
258594013926	H-loop/switch region; other site
258594013927	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
258594013928	2 probable transmembrane helices predicted byTMHMM2.0
258594013929	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
258594013930	3 probable transmembrane helices predicted byTMHMM2.0
258594013931	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
258594013932	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
258594013933	ATP binding site [chemical binding]; other site
258594013934	Walker A motif; other site
258594013935	hexamer interface [polypeptide binding]; other site
258594013936	Walker B motif; other site
258594013937	hypothetical protein; Provisional; Region: PRK06153
258594013938	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
258594013939	ATP binding site [chemical binding]; other site
258594013940	substrate interface [chemical binding]; other site
258594013941	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
258594013942	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
258594013943	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
258594013944	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
258594013945	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
258594013946	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594013947	non-specific DNA binding site [nucleotide binding]; other site
258594013948	salt bridge; other site
258594013949	sequence-specific DNA binding site [nucleotide binding]; other site
258594013950	Domain of unknown function (DUF955); Region: DUF955; pfam06114
258594013951	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
258594013952	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
258594013953	Walker A motif; other site
258594013954	ATP binding site [chemical binding]; other site
258594013955	Walker B motif; other site
258594013956	3 probable transmembrane helices predicted byTMHMM2.0
258594013957	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
258594013958	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594013959	non-specific DNA binding site [nucleotide binding]; other site
258594013960	salt bridge; other site
258594013961	sequence-specific DNA binding site [nucleotide binding]; other site
258594013962	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
258594013963	domain III; other site
258594013964	DNA binding groove [nucleotide binding]
258594013965	catalytic site [active]
258594013966	nucleotide binding site [chemical binding]; other site
258594013967	domain II; other site
258594013968	domain IV; other site
258594013969	phasin; Region: phasin_2; TIGR01985
258594013970	Phasin protein; Region: Phasin_2; cl11491
258594013971	PAS domain; Region: PAS_9; pfam13426
258594013972	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594013973	putative active site [active]
258594013974	heme pocket [chemical binding]; other site
258594013975	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594013976	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594013977	dimer interface [polypeptide binding]; other site
258594013978	phosphorylation site [posttranslational modification]
258594013979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594013980	ATP binding site [chemical binding]; other site
258594013981	Mg2+ binding site [ion binding]; other site
258594013982	G-X-G motif; other site
258594013983	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
258594013984	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
258594013985	putative active site [active]
258594013986	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594013987	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594013988	ligand binding site [chemical binding]; other site
258594013989	flexible hinge region; other site
258594013990	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
258594013991	putative switch regulator; other site
258594013992	non-specific DNA interactions [nucleotide binding]; other site
258594013993	DNA binding site [nucleotide binding]
258594013994	sequence specific DNA binding site [nucleotide binding]; other site
258594013995	putative cAMP binding site [chemical binding]; other site
258594013996	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
258594013997	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
258594013998	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
258594013999	Multicopper oxidase; Region: Cu-oxidase; pfam00394
258594014000	1 probable transmembrane helix predicted byTMHMM2.0
258594014001	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
258594014002	Uncharacterized conserved protein [Function unknown]; Region: COG1262
258594014003	thymidine phosphorylase; Provisional; Region: PRK04350
258594014004	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
258594014005	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
258594014006	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
258594014007	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
258594014008	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
258594014009	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
258594014010	active site
258594014011	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
258594014012	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
258594014013	Beta-Casp domain; Region: Beta-Casp; smart01027
258594014014	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
258594014015	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
258594014016	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594014017	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
258594014018	dimerization interface [polypeptide binding]; other site
258594014019	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
258594014020	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
258594014021	1 probable transmembrane helix predicted byTMHMM2.0
258594014022	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
258594014023	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594014024	dimer interface [polypeptide binding]; other site
258594014025	conserved gate region; other site
258594014026	ABC-ATPase subunit interface; other site
258594014027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594014028	putative PBP binding loops; other site
258594014029	ABC-ATPase subunit interface; other site
258594014030	11 probable transmembrane helices predicted byTMHMM2.0
258594014031	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
258594014032	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
258594014033	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
258594014034	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
258594014035	1 probable transmembrane helix predicted byTMHMM2.0
258594014036	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
258594014037	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594014038	dimer interface [polypeptide binding]; other site
258594014039	conserved gate region; other site
258594014040	putative PBP binding loops; other site
258594014041	ABC-ATPase subunit interface; other site
258594014042	6 probable transmembrane helices predicted byTMHMM2.0
258594014043	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594014044	dimer interface [polypeptide binding]; other site
258594014045	conserved gate region; other site
258594014046	putative PBP binding loops; other site
258594014047	ABC-ATPase subunit interface; other site
258594014048	6 probable transmembrane helices predicted byTMHMM2.0
258594014049	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
258594014050	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
258594014051	Walker A/P-loop; other site
258594014052	ATP binding site [chemical binding]; other site
258594014053	Q-loop/lid; other site
258594014054	ABC transporter signature motif; other site
258594014055	Walker B; other site
258594014056	D-loop; other site
258594014057	H-loop/switch region; other site
258594014058	TOBE domain; Region: TOBE_2; pfam08402
258594014059	Predicted transcriptional regulators [Transcription]; Region: COG1378
258594014060	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594014061	putative Zn2+ binding site [ion binding]; other site
258594014062	putative DNA binding site [nucleotide binding]; other site
258594014063	dimerization interface [polypeptide binding]; other site
258594014064	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
258594014065	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594014066	dimer interface [polypeptide binding]; other site
258594014067	conserved gate region; other site
258594014068	putative PBP binding loops; other site
258594014069	ABC-ATPase subunit interface; other site
258594014070	6 probable transmembrane helices predicted byTMHMM2.0
258594014071	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
258594014072	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
258594014073	Walker A/P-loop; other site
258594014074	ATP binding site [chemical binding]; other site
258594014075	Q-loop/lid; other site
258594014076	ABC transporter signature motif; other site
258594014077	Walker B; other site
258594014078	D-loop; other site
258594014079	H-loop/switch region; other site
258594014080	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
258594014081	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
258594014082	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
258594014083	Predicted amidohydrolase [General function prediction only]; Region: COG0388
258594014084	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
258594014085	putative active site [active]
258594014086	catalytic triad [active]
258594014087	putative dimer interface [polypeptide binding]; other site
258594014088	PAS domain; Region: PAS; smart00091
258594014089	PAS fold; Region: PAS_7; pfam12860
258594014090	PAS fold; Region: PAS_4; pfam08448
258594014091	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594014092	putative active site [active]
258594014093	heme pocket [chemical binding]; other site
258594014094	PAS fold; Region: PAS_4; pfam08448
258594014095	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594014096	metal binding site [ion binding]; metal-binding site
258594014097	active site
258594014098	I-site; other site
258594014099	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594014100	1 probable transmembrane helix predicted byTMHMM2.0
258594014101	Predicted dehydrogenase [General function prediction only]; Region: COG0579
258594014102	hydroxyglutarate oxidase; Provisional; Region: PRK11728
258594014103	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
258594014104	DNA-binding site [nucleotide binding]; DNA binding site
258594014105	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
258594014106	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
258594014107	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594014108	putative ligand binding site [chemical binding]; other site
258594014109	Uncharacterized small protein [Function unknown]; Region: COG5570
258594014110	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594014111	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594014112	metal binding site [ion binding]; metal-binding site
258594014113	active site
258594014114	I-site; other site
258594014115	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
258594014116	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
258594014117	ATP-grasp domain; Region: ATP-grasp; pfam02222
258594014118	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
258594014119	Cupin domain; Region: Cupin_2; cl17218
258594014120	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
258594014121	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
258594014122	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
258594014123	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
258594014124	8 probable transmembrane helices predicted byTMHMM2.0
258594014125	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
258594014126	3 probable transmembrane helices predicted byTMHMM2.0
258594014127	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
258594014128	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
258594014129	ligand binding site [chemical binding]; other site
258594014130	homodimer interface [polypeptide binding]; other site
258594014131	NAD(P) binding site [chemical binding]; other site
258594014132	trimer interface B [polypeptide binding]; other site
258594014133	trimer interface A [polypeptide binding]; other site
258594014134	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
258594014135	1 probable transmembrane helix predicted byTMHMM2.0
258594014136	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
258594014137	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
258594014138	active site
258594014139	Zn binding site [ion binding]; other site
258594014140	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
258594014141	5 probable transmembrane helices predicted byTMHMM2.0
258594014142	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
258594014143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594014144	active site
258594014145	phosphorylation site [posttranslational modification]
258594014146	intermolecular recognition site; other site
258594014147	dimerization interface [polypeptide binding]; other site
258594014148	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594014149	Walker A motif; other site
258594014150	ATP binding site [chemical binding]; other site
258594014151	Walker B motif; other site
258594014152	arginine finger; other site
258594014153	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
258594014154	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
258594014155	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
258594014156	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
258594014157	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
258594014158	1 probable transmembrane helix predicted byTMHMM2.0
258594014159	Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951
258594014160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
258594014161	hypothetical protein; Provisional; Region: PRK13694
258594014162	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
258594014163	Protein of unknown function (DUF1036); Region: DUF1036; pfam06282
258594014164	pyruvate kinase; Provisional; Region: PRK06247
258594014165	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
258594014166	domain interfaces; other site
258594014167	active site
258594014168	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
258594014169	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
258594014170	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
258594014171	catalytic site [active]
258594014172	1 probable transmembrane helix predicted byTMHMM2.0
258594014173	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594014174	binding surface
258594014175	TPR motif; other site
258594014176	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
258594014177	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
258594014178	active site
258594014179	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
258594014180	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594014181	motif II; other site
258594014182	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
258594014183	putative deacylase active site [active]
258594014184	1 probable transmembrane helix predicted byTMHMM2.0
258594014185	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
258594014186	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594014187	dimer interface [polypeptide binding]; other site
258594014188	putative CheW interface [polypeptide binding]; other site
258594014189	2 probable transmembrane helices predicted byTMHMM2.0
258594014190	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594014191	PAS fold; Region: PAS_3; pfam08447
258594014192	putative active site [active]
258594014193	heme pocket [chemical binding]; other site
258594014194	2 probable transmembrane helices predicted byTMHMM2.0
258594014195	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
258594014196	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
258594014197	12 probable transmembrane helices predicted byTMHMM2.0
258594014198	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
258594014199	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
258594014200	NAD binding site [chemical binding]; other site
258594014201	homotetramer interface [polypeptide binding]; other site
258594014202	homodimer interface [polypeptide binding]; other site
258594014203	substrate binding site [chemical binding]; other site
258594014204	active site
258594014205	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
258594014206	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
258594014207	Patatin phospholipase; Region: DUF3734; pfam12536
258594014208	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
258594014209	glutamine synthetase; Region: PLN02284
258594014210	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
258594014211	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
258594014212	Protein of unknown function (DUF2735); Region: DUF2735; pfam10931
258594014213	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
258594014214	glutaminase; Provisional; Region: PRK00971
258594014215	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
258594014216	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
258594014217	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
258594014218	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
258594014219	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
258594014220	siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470
258594014221	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
258594014222	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
258594014223	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
258594014224	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
258594014225	active site
258594014226	SAM binding site [chemical binding]; other site
258594014227	homodimer interface [polypeptide binding]; other site
258594014228	malate synthase G; Provisional; Region: PRK02999
258594014229	active site
258594014230	CsbD-like; Region: CsbD; cl17424
258594014231	2 probable transmembrane helices predicted byTMHMM2.0
258594014232	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
258594014233	1 probable transmembrane helix predicted byTMHMM2.0
258594014234	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
258594014235	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
258594014236	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
258594014237	Domain of unknown function DUF20; Region: UPF0118; pfam01594
258594014238	8 probable transmembrane helices predicted byTMHMM2.0
258594014239	1 probable transmembrane helix predicted byTMHMM2.0
258594014240	two-component response regulator; Provisional; Region: PRK09191
258594014241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594014242	active site
258594014243	phosphorylation site [posttranslational modification]
258594014244	intermolecular recognition site; other site
258594014245	dimerization interface [polypeptide binding]; other site
258594014246	RNA polymerase sigma factor; Provisional; Region: PRK12540
258594014247	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594014248	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
258594014249	DNA binding residues [nucleotide binding]
258594014250	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
258594014251	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
258594014252	HWE histidine kinase; Region: HWE_HK; pfam07536
258594014253	2 probable transmembrane helices predicted byTMHMM2.0
258594014254	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
258594014255	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
258594014256	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
258594014257	putative [4Fe-4S] binding site [ion binding]; other site
258594014258	putative molybdopterin cofactor binding site [chemical binding]; other site
258594014259	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
258594014260	putative molybdopterin cofactor binding site; other site
258594014261	Ion transport protein; Region: Ion_trans; pfam00520
258594014262	Ion channel; Region: Ion_trans_2; pfam07885
258594014263	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594014264	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594014265	ligand binding site [chemical binding]; other site
258594014266	flexible hinge region; other site
258594014267	5 probable transmembrane helices predicted byTMHMM2.0
258594014268	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594014269	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594014270	ligand binding site [chemical binding]; other site
258594014271	flexible hinge region; other site
258594014272	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
258594014273	putative switch regulator; other site
258594014274	non-specific DNA interactions [nucleotide binding]; other site
258594014275	DNA binding site [nucleotide binding]
258594014276	sequence specific DNA binding site [nucleotide binding]; other site
258594014277	putative cAMP binding site [chemical binding]; other site
258594014278	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
258594014279	Cytochrome c; Region: Cytochrom_C; pfam00034
258594014280	1 probable transmembrane helix predicted byTMHMM2.0
258594014281	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
258594014282	mce related protein; Region: MCE; pfam02470
258594014283	Protein of unknown function (DUF330); Region: DUF330; cl01135
258594014284	1 probable transmembrane helix predicted byTMHMM2.0
258594014285	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
258594014286	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
258594014287	Walker A/P-loop; other site
258594014288	ATP binding site [chemical binding]; other site
258594014289	Q-loop/lid; other site
258594014290	ABC transporter signature motif; other site
258594014291	Walker B; other site
258594014292	D-loop; other site
258594014293	H-loop/switch region; other site
258594014294	STAS domain; Region: STAS_2; pfam13466
258594014295	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
258594014296	Permease; Region: Permease; pfam02405
258594014297	6 probable transmembrane helices predicted byTMHMM2.0
258594014298	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
258594014299	CoA binding domain; Region: CoA_binding_2; pfam13380
258594014300	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
258594014301	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
258594014302	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
258594014303	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594014304	Coenzyme A binding pocket [chemical binding]; other site
258594014305	FOG: CBS domain [General function prediction only]; Region: COG0517
258594014306	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
258594014307	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
258594014308	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
258594014309	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
258594014310	substrate binding site [chemical binding]; other site
258594014311	Predicted kinase [General function prediction only]; Region: COG0645
258594014312	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
258594014313	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
258594014314	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
258594014315	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
258594014316	Ligand Binding Site [chemical binding]; other site
258594014317	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
258594014318	Ligand Binding Site [chemical binding]; other site
258594014319	FOG: CBS domain [General function prediction only]; Region: COG0517
258594014320	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
258594014321	BON domain; Region: BON; pfam04972
258594014322	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594014323	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
258594014324	putative active site [active]
258594014325	heme pocket [chemical binding]; other site
258594014326	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
258594014327	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594014328	putative active site [active]
258594014329	heme pocket [chemical binding]; other site
258594014330	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594014331	dimer interface [polypeptide binding]; other site
258594014332	phosphorylation site [posttranslational modification]
258594014333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594014334	ATP binding site [chemical binding]; other site
258594014335	Mg2+ binding site [ion binding]; other site
258594014336	G-X-G motif; other site
258594014337	response regulator FixJ; Provisional; Region: fixJ; PRK09390
258594014338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594014339	active site
258594014340	phosphorylation site [posttranslational modification]
258594014341	intermolecular recognition site; other site
258594014342	dimerization interface [polypeptide binding]; other site
258594014343	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
258594014344	DNA binding residues [nucleotide binding]
258594014345	dimerization interface [polypeptide binding]; other site
258594014346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594014347	active site
258594014348	phosphorylation site [posttranslational modification]
258594014349	intermolecular recognition site; other site
258594014350	dimerization interface [polypeptide binding]; other site
258594014351	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
258594014352	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594014353	ligand binding site [chemical binding]; other site
258594014354	flexible hinge region; other site
258594014355	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
258594014356	putative switch regulator; other site
258594014357	non-specific DNA interactions [nucleotide binding]; other site
258594014358	DNA binding site [nucleotide binding]
258594014359	sequence specific DNA binding site [nucleotide binding]; other site
258594014360	putative cAMP binding site [chemical binding]; other site
258594014361	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
258594014362	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
258594014363	homodimer interface [polypeptide binding]; other site
258594014364	substrate-cofactor binding pocket; other site
258594014365	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594014366	catalytic residue [active]
258594014367	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
258594014368	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
258594014369	14 probable transmembrane helices predicted byTMHMM2.0
258594014370	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
258594014371	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
258594014372	14 probable transmembrane helices predicted byTMHMM2.0
258594014373	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
258594014374	15 probable transmembrane helices predicted byTMHMM2.0
258594014375	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
258594014376	3 probable transmembrane helices predicted byTMHMM2.0
258594014377	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
258594014378	5 probable transmembrane helices predicted byTMHMM2.0
258594014379	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
258594014380	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
258594014381	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
258594014382	9 probable transmembrane helices predicted byTMHMM2.0
258594014383	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
258594014384	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
258594014385	catalytic loop [active]
258594014386	iron binding site [ion binding]; other site
258594014387	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
258594014388	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
258594014389	[4Fe-4S] binding site [ion binding]; other site
258594014390	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
258594014391	SLBB domain; Region: SLBB; pfam10531
258594014392	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
258594014393	NADH dehydrogenase subunit E; Validated; Region: PRK07539
258594014394	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
258594014395	putative dimer interface [polypeptide binding]; other site
258594014396	[2Fe-2S] cluster binding site [ion binding]; other site
258594014397	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
258594014398	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
258594014399	NADH dehydrogenase subunit D; Validated; Region: PRK06075
258594014400	NADH dehydrogenase subunit B; Validated; Region: PRK06411
258594014401	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
258594014402	3 probable transmembrane helices predicted byTMHMM2.0
258594014403	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
258594014404	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
258594014405	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594014406	Walker A/P-loop; other site
258594014407	ATP binding site [chemical binding]; other site
258594014408	Q-loop/lid; other site
258594014409	ABC transporter signature motif; other site
258594014410	Walker B; other site
258594014411	D-loop; other site
258594014412	H-loop/switch region; other site
258594014413	5 probable transmembrane helices predicted byTMHMM2.0
258594014414	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
258594014415	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
258594014416	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
258594014417	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
258594014418	acyl-activating enzyme (AAE) consensus motif; other site
258594014419	putative AMP binding site [chemical binding]; other site
258594014420	putative active site [active]
258594014421	putative CoA binding site [chemical binding]; other site
258594014422	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
258594014423	catalytic triad [active]
258594014424	dimer interface [polypeptide binding]; other site
258594014425	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
258594014426	RNA/DNA hybrid binding site [nucleotide binding]; other site
258594014427	active site
258594014428	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
258594014429	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
258594014430	putative active site [active]
258594014431	putative substrate binding site [chemical binding]; other site
258594014432	ATP binding site [chemical binding]; other site
258594014433	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
258594014434	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
258594014435	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
258594014436	Divergent AAA domain; Region: AAA_4; pfam04326
258594014437	2 probable transmembrane helices predicted byTMHMM2.0
258594014438	HEAT repeats; Region: HEAT_2; pfam13646
258594014439	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
258594014440	3 probable transmembrane helices predicted byTMHMM2.0
258594014441	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
258594014442	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594014443	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
258594014444	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
258594014445	1 probable transmembrane helix predicted byTMHMM2.0
258594014446	Sensors of blue-light using FAD; Region: BLUF; smart01034
258594014447	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594014448	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594014449	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
258594014450	dimerization interface [polypeptide binding]; other site
258594014451	Uncharacterized conserved protein [Function unknown]; Region: COG2353
258594014452	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
258594014453	putative FMN binding site [chemical binding]; other site
258594014454	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
258594014455	putative active site [active]
258594014456	metal binding site [ion binding]; metal-binding site
258594014457	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594014458	S-adenosylmethionine binding site [chemical binding]; other site
258594014459	HipA-like N-terminal domain; Region: HipA_N; pfam07805
258594014460	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
258594014461	active site
258594014462	catalytic residues [active]
258594014463	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
258594014464	4 probable transmembrane helices predicted byTMHMM2.0
258594014465	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
258594014466	1 probable transmembrane helix predicted byTMHMM2.0
258594014467	1 probable transmembrane helix predicted byTMHMM2.0
258594014468	1 probable transmembrane helix predicted byTMHMM2.0
258594014469	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
258594014470	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
258594014471	GDP-binding site [chemical binding]; other site
258594014472	ACT binding site; other site
258594014473	IMP binding site; other site
258594014474	PilZ domain; Region: PilZ; pfam07238
258594014475	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
258594014476	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
258594014477	active site
258594014478	catalytic tetrad [active]
258594014479	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
258594014480	putative deacylase active site [active]
258594014481	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
258594014482	EamA-like transporter family; Region: EamA; pfam00892
258594014483	EamA-like transporter family; Region: EamA; pfam00892
258594014484	10 probable transmembrane helices predicted byTMHMM2.0
258594014485	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
258594014486	EamA-like transporter family; Region: EamA; pfam00892
258594014487	EamA-like transporter family; Region: EamA; pfam00892
258594014488	10 probable transmembrane helices predicted byTMHMM2.0
258594014489	Cache domain; Region: Cache_1; pfam02743
258594014490	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
258594014491	dimerization interface [polypeptide binding]; other site
258594014492	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
258594014493	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594014494	dimer interface [polypeptide binding]; other site
258594014495	putative CheW interface [polypeptide binding]; other site
258594014496	2 probable transmembrane helices predicted byTMHMM2.0
258594014497	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
258594014498	diiron binding motif [ion binding]; other site
258594014499	Uncharacterized conserved protein [Function unknown]; Region: COG1633
258594014500	CCC1-related family of proteins; Region: CCC1_like; cl00278
258594014501	5 probable transmembrane helices predicted byTMHMM2.0
258594014502	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
258594014503	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
258594014504	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
258594014505	dimerization interface [polypeptide binding]; other site
258594014506	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594014507	dimer interface [polypeptide binding]; other site
258594014508	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
258594014509	putative CheW interface [polypeptide binding]; other site
258594014510	2 probable transmembrane helices predicted byTMHMM2.0
258594014511	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
258594014512	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
258594014513	dimerization interface [polypeptide binding]; other site
258594014514	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
258594014515	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594014516	dimer interface [polypeptide binding]; other site
258594014517	putative CheW interface [polypeptide binding]; other site
258594014518	2 probable transmembrane helices predicted byTMHMM2.0
258594014519	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
258594014520	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
258594014521	ligand binding site [chemical binding]; other site
258594014522	NAD binding site [chemical binding]; other site
258594014523	dimerization interface [polypeptide binding]; other site
258594014524	catalytic site [active]
258594014525	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
258594014526	putative L-serine binding site [chemical binding]; other site
258594014527	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
258594014528	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594014529	catalytic residue [active]
258594014530	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
258594014531	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594014532	dimer interface [polypeptide binding]; other site
258594014533	putative CheW interface [polypeptide binding]; other site
258594014534	2 probable transmembrane helices predicted byTMHMM2.0
258594014535	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594014536	PAS fold; Region: PAS_3; pfam08447
258594014537	putative active site [active]
258594014538	heme pocket [chemical binding]; other site
258594014539	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
258594014540	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594014541	Coenzyme A binding pocket [chemical binding]; other site
258594014542	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
258594014543	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
258594014544	putative C-terminal domain interface [polypeptide binding]; other site
258594014545	putative GSH binding site (G-site) [chemical binding]; other site
258594014546	putative dimer interface [polypeptide binding]; other site
258594014547	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
258594014548	N-terminal domain interface [polypeptide binding]; other site
258594014549	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
258594014550	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
258594014551	Major Facilitator Superfamily; Region: MFS_1; pfam07690
258594014552	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594014553	putative substrate translocation pore; other site
258594014554	9 probable transmembrane helices predicted byTMHMM2.0
258594014555	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
258594014556	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
258594014557	active site
258594014558	substrate binding site [chemical binding]; other site
258594014559	metal binding site [ion binding]; metal-binding site
258594014560	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
258594014561	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
258594014562	phosphate binding site [ion binding]; other site
258594014563	enoyl-CoA hydratase; Provisional; Region: PRK08140
258594014564	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594014565	substrate binding site [chemical binding]; other site
258594014566	oxyanion hole (OAH) forming residues; other site
258594014567	trimer interface [polypeptide binding]; other site
258594014568	Response regulator receiver domain; Region: Response_reg; pfam00072
258594014569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594014570	active site
258594014571	phosphorylation site [posttranslational modification]
258594014572	intermolecular recognition site; other site
258594014573	dimerization interface [polypeptide binding]; other site
258594014574	4 probable transmembrane helices predicted byTMHMM2.0
258594014575	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
258594014576	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
258594014577	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
258594014578	shikimate binding site; other site
258594014579	NAD(P) binding site [chemical binding]; other site
258594014580	putative transporter; Provisional; Region: PRK11660
258594014581	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
258594014582	Sulfate transporter family; Region: Sulfate_transp; pfam00916
258594014583	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
258594014584	11 probable transmembrane helices predicted byTMHMM2.0
258594014585	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
258594014586	sequence-specific DNA binding site [nucleotide binding]; other site
258594014587	salt bridge; other site
258594014588	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
258594014589	elongation factor G; Reviewed; Region: PRK12740
258594014590	G1 box; other site
258594014591	putative GEF interaction site [polypeptide binding]; other site
258594014592	GTP/Mg2+ binding site [chemical binding]; other site
258594014593	Switch I region; other site
258594014594	G2 box; other site
258594014595	G3 box; other site
258594014596	Switch II region; other site
258594014597	G4 box; other site
258594014598	G5 box; other site
258594014599	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
258594014600	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
258594014601	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
258594014602	Protein of unknown function (DUF992); Region: DUF992; pfam06186
258594014603	Protein of unknown function (DUF992); Region: DUF992; pfam06186
258594014604	aspartate aminotransferase; Provisional; Region: PRK05764
258594014605	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
258594014606	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594014607	homodimer interface [polypeptide binding]; other site
258594014608	catalytic residue [active]
258594014609	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
258594014610	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
258594014611	putative C-terminal domain interface [polypeptide binding]; other site
258594014612	putative GSH binding site (G-site) [chemical binding]; other site
258594014613	putative dimer interface [polypeptide binding]; other site
258594014614	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
258594014615	dimer interface [polypeptide binding]; other site
258594014616	N-terminal domain interface [polypeptide binding]; other site
258594014617	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
258594014618	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
258594014619	1 probable transmembrane helix predicted byTMHMM2.0
258594014620	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
258594014621	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
258594014622	putative acyl-acceptor binding pocket; other site
258594014623	1 probable transmembrane helix predicted byTMHMM2.0
258594014624	replicative DNA helicase; Provisional; Region: PRK05973
258594014625	Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305
258594014626	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
258594014627	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
258594014628	active site
258594014629	catalytic tetrad [active]
258594014630	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
258594014631	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
258594014632	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594014633	motif II; other site
258594014634	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594014635	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594014636	enoyl-CoA hydratase; Provisional; Region: PRK05980
258594014637	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
258594014638	substrate binding site [chemical binding]; other site
258594014639	oxyanion hole (OAH) forming residues; other site
258594014640	trimer interface [polypeptide binding]; other site
258594014641	GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038
258594014642	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
258594014643	putative C-terminal domain interface [polypeptide binding]; other site
258594014644	putative GSH binding site (G-site) [chemical binding]; other site
258594014645	putative dimer interface [polypeptide binding]; other site
258594014646	C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202
258594014647	putative N-terminal domain interface [polypeptide binding]; other site
258594014648	putative dimer interface [polypeptide binding]; other site
258594014649	putative substrate binding pocket (H-site) [chemical binding]; other site
258594014650	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
258594014651	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
258594014652	9 probable transmembrane helices predicted byTMHMM2.0
258594014653	excinuclease ABC subunit B; Provisional; Region: PRK05298
258594014654	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
258594014655	ATP binding site [chemical binding]; other site
258594014656	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
258594014657	nucleotide binding region [chemical binding]; other site
258594014658	ATP-binding site [chemical binding]; other site
258594014659	Ultra-violet resistance protein B; Region: UvrB; pfam12344
258594014660	UvrB/uvrC motif; Region: UVR; pfam02151
258594014661	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
258594014662	acetyl-CoA acetyltransferase; Provisional; Region: PRK06025
258594014663	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
258594014664	dimer interface [polypeptide binding]; other site
258594014665	active site
258594014666	SnoaL-like domain; Region: SnoaL_2; pfam12680
258594014667	1 probable transmembrane helix predicted byTMHMM2.0
258594014668	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
258594014669	putative active site [active]
258594014670	putative catalytic site [active]
258594014671	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
258594014672	putative active site [active]
258594014673	putative catalytic site [active]
258594014674	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
258594014675	2 probable transmembrane helices predicted byTMHMM2.0
258594014676	GTP-binding protein YchF; Reviewed; Region: PRK09601
258594014677	YchF GTPase; Region: YchF; cd01900
258594014678	G1 box; other site
258594014679	GTP/Mg2+ binding site [chemical binding]; other site
258594014680	Switch I region; other site
258594014681	G2 box; other site
258594014682	Switch II region; other site
258594014683	G3 box; other site
258594014684	G4 box; other site
258594014685	G5 box; other site
258594014686	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
258594014687	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
258594014688	putative active site [active]
258594014689	catalytic residue [active]
258594014690	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
258594014691	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
258594014692	5S rRNA interface [nucleotide binding]; other site
258594014693	CTC domain interface [polypeptide binding]; other site
258594014694	L16 interface [polypeptide binding]; other site
258594014695	Membrane fusogenic activity; Region: BMFP; pfam04380
258594014696	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
258594014697	7 probable transmembrane helices predicted byTMHMM2.0
258594014698	Uncharacterized conserved protein [Function unknown]; Region: COG1565
258594014699	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
258594014700	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
258594014701	1 probable transmembrane helix predicted byTMHMM2.0
258594014702	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
258594014703	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
258594014704	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
258594014705	active site
258594014706	riboflavin synthase subunit beta; Provisional; Region: PRK12419
258594014707	active site
258594014708	homopentamer interface [polypeptide binding]; other site
258594014709	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
258594014710	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594014711	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
258594014712	Coenzyme A binding pocket [chemical binding]; other site
258594014713	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
258594014714	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
258594014715	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594014716	HAMP domain; Region: HAMP; pfam00672
258594014717	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594014718	dimer interface [polypeptide binding]; other site
258594014719	phosphorylation site [posttranslational modification]
258594014720	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594014721	ATP binding site [chemical binding]; other site
258594014722	Mg2+ binding site [ion binding]; other site
258594014723	G-X-G motif; other site
258594014724	2 probable transmembrane helices predicted byTMHMM2.0
258594014725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594014726	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
258594014727	active site
258594014728	phosphorylation site [posttranslational modification]
258594014729	intermolecular recognition site; other site
258594014730	dimerization interface [polypeptide binding]; other site
258594014731	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
258594014732	DNA binding site [nucleotide binding]
258594014733	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
258594014734	MarR family; Region: MarR_2; pfam12802
258594014735	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
258594014736	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
258594014737	homodimer interface [polypeptide binding]; other site
258594014738	substrate-cofactor binding pocket; other site
258594014739	catalytic residue [active]
258594014740	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
258594014741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594014742	ATP binding site [chemical binding]; other site
258594014743	Mg2+ binding site [ion binding]; other site
258594014744	G-X-G motif; other site
258594014745	DNA mismatch repair protein, C-terminal domain; Region: DNA_mis_repair; pfam01119
258594014746	ATP binding site [chemical binding]; other site
258594014747	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
258594014748	hypothetical protein; Provisional; Region: PRK09256
258594014749	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
258594014750	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
258594014751	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
258594014752	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
258594014753	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
258594014754	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
258594014755	lipoprotein signal peptidase; Provisional; Region: PRK14796
258594014756	5 probable transmembrane helices predicted byTMHMM2.0
258594014757	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
258594014758	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
258594014759	active site
258594014760	HIGH motif; other site
258594014761	nucleotide binding site [chemical binding]; other site
258594014762	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
258594014763	active site
258594014764	KMSKS motif; other site
258594014765	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
258594014766	tRNA binding surface [nucleotide binding]; other site
258594014767	anticodon binding site; other site
258594014768	maltose O-acetyltransferase; Provisional; Region: PRK10092
258594014769	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
258594014770	active site
258594014771	substrate binding site [chemical binding]; other site
258594014772	trimer interface [polypeptide binding]; other site
258594014773	CoA binding site [chemical binding]; other site
258594014774	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
258594014775	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
258594014776	active site
258594014777	Riboflavin kinase; Region: Flavokinase; smart00904
258594014778	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
258594014779	B1 nucleotide binding pocket [chemical binding]; other site
258594014780	B2 nucleotide binding pocket [chemical binding]; other site
258594014781	CAS motifs; other site
258594014782	active site
258594014783	1 probable transmembrane helix predicted byTMHMM2.0
258594014784	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
258594014785	1 probable transmembrane helix predicted byTMHMM2.0
258594014786	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
258594014787	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
258594014788	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
258594014789	1 probable transmembrane helix predicted byTMHMM2.0
258594014790	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
258594014791	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
258594014792	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
258594014793	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594014794	Coenzyme A binding pocket [chemical binding]; other site
258594014795	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
258594014796	Mechanosensitive ion channel; Region: MS_channel; pfam00924
258594014797	5 probable transmembrane helices predicted byTMHMM2.0
258594014798	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
258594014799	nudix motif; other site
258594014800	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
258594014801	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
258594014802	putative active site [active]
258594014803	putative metal binding site [ion binding]; other site
258594014804	1 probable transmembrane helix predicted byTMHMM2.0
258594014805	isocitrate lyase; Provisional; Region: PRK15063
258594014806	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
258594014807	tetramer interface [polypeptide binding]; other site
258594014808	active site
258594014809	Mg2+/Mn2+ binding site [ion binding]; other site
258594014810	isocitrate lyase; Region: PLN02892
258594014811	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
258594014812	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594014813	non-specific DNA binding site [nucleotide binding]; other site
258594014814	salt bridge; other site
258594014815	sequence-specific DNA binding site [nucleotide binding]; other site
258594014816	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
258594014817	Domain of unknown function (DUF955); Region: DUF955; pfam06114
258594014818	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
258594014819	lytic murein transglycosylase; Region: MltB_2; TIGR02283
258594014820	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
258594014821	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
258594014822	N-acetyl-D-glucosamine binding site [chemical binding]; other site
258594014823	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
258594014824	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594014825	Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328
258594014826	putative ligand binding site [chemical binding]; other site
258594014827	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
258594014828	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
258594014829	Walker A/P-loop; other site
258594014830	ATP binding site [chemical binding]; other site
258594014831	Q-loop/lid; other site
258594014832	ABC transporter signature motif; other site
258594014833	Walker B; other site
258594014834	D-loop; other site
258594014835	H-loop/switch region; other site
258594014836	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
258594014837	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
258594014838	Walker A/P-loop; other site
258594014839	ATP binding site [chemical binding]; other site
258594014840	Q-loop/lid; other site
258594014841	ABC transporter signature motif; other site
258594014842	Walker B; other site
258594014843	D-loop; other site
258594014844	H-loop/switch region; other site
258594014845	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594014846	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
258594014847	TM-ABC transporter signature motif; other site
258594014848	9 probable transmembrane helices predicted byTMHMM2.0
258594014849	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
258594014850	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
258594014851	TM-ABC transporter signature motif; other site
258594014852	10 probable transmembrane helices predicted byTMHMM2.0
258594014853	3 probable transmembrane helices predicted byTMHMM2.0
258594014854	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
258594014855	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
258594014856	FMN binding site [chemical binding]; other site
258594014857	active site
258594014858	substrate binding site [chemical binding]; other site
258594014859	catalytic residue [active]
258594014860	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
258594014861	1 probable transmembrane helix predicted byTMHMM2.0
258594014862	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
258594014863	3 probable transmembrane helices predicted byTMHMM2.0
258594014864	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
258594014865	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594014866	dimer interface [polypeptide binding]; other site
258594014867	conserved gate region; other site
258594014868	putative PBP binding loops; other site
258594014869	ABC-ATPase subunit interface; other site
258594014870	6 probable transmembrane helices predicted byTMHMM2.0
258594014871	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
258594014872	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594014873	dimer interface [polypeptide binding]; other site
258594014874	conserved gate region; other site
258594014875	putative PBP binding loops; other site
258594014876	ABC-ATPase subunit interface; other site
258594014877	6 probable transmembrane helices predicted byTMHMM2.0
258594014878	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
258594014879	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
258594014880	Walker A/P-loop; other site
258594014881	ATP binding site [chemical binding]; other site
258594014882	Q-loop/lid; other site
258594014883	ABC transporter signature motif; other site
258594014884	Walker B; other site
258594014885	D-loop; other site
258594014886	H-loop/switch region; other site
258594014887	TOBE domain; Region: TOBE_2; pfam08402
258594014888	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
258594014889	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
258594014890	Walker A/P-loop; other site
258594014891	ATP binding site [chemical binding]; other site
258594014892	Q-loop/lid; other site
258594014893	ABC transporter signature motif; other site
258594014894	Walker B; other site
258594014895	D-loop; other site
258594014896	H-loop/switch region; other site
258594014897	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
258594014898	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
258594014899	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
258594014900	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
258594014901	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
258594014902	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
258594014903	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
258594014904	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
258594014905	12 probable transmembrane helices predicted byTMHMM2.0
258594014906	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
258594014907	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594014908	1 probable transmembrane helix predicted byTMHMM2.0
258594014909	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
258594014910	dimer interface [polypeptide binding]; other site
258594014911	PAS fold; Region: PAS_4; pfam08448
258594014912	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594014913	putative active site [active]
258594014914	heme pocket [chemical binding]; other site
258594014915	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594014916	dimer interface [polypeptide binding]; other site
258594014917	phosphorylation site [posttranslational modification]
258594014918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594014919	ATP binding site [chemical binding]; other site
258594014920	Mg2+ binding site [ion binding]; other site
258594014921	G-X-G motif; other site
258594014922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594014923	active site
258594014924	phosphorylation site [posttranslational modification]
258594014925	intermolecular recognition site; other site
258594014926	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
258594014927	putative binding surface; other site
258594014928	active site
258594014929	5 probable transmembrane helices predicted byTMHMM2.0
258594014930	CsbD-like; Region: CsbD; pfam05532
258594014931	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
258594014932	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
258594014933	SlyX; Region: SlyX; pfam04102
258594014934	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
258594014935	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594014936	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
258594014937	acyl-activating enzyme (AAE) consensus motif; other site
258594014938	acyl-activating enzyme (AAE) consensus motif; other site
258594014939	putative AMP binding site [chemical binding]; other site
258594014940	putative active site [active]
258594014941	putative CoA binding site [chemical binding]; other site
258594014942	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594014943	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594014944	ligand binding site [chemical binding]; other site
258594014945	flexible hinge region; other site
258594014946	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
258594014947	non-specific DNA interactions [nucleotide binding]; other site
258594014948	DNA binding site [nucleotide binding]
258594014949	sequence specific DNA binding site [nucleotide binding]; other site
258594014950	putative cAMP binding site [chemical binding]; other site
258594014951	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
258594014952	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
258594014953	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
258594014954	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
258594014955	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
258594014956	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
258594014957	putative C-terminal domain interface [polypeptide binding]; other site
258594014958	putative GSH binding site (G-site) [chemical binding]; other site
258594014959	putative dimer interface [polypeptide binding]; other site
258594014960	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
258594014961	N-terminal domain interface [polypeptide binding]; other site
258594014962	dimer interface [polypeptide binding]; other site
258594014963	putative substrate binding pocket (H-site) [chemical binding]; other site
258594014964	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
258594014965	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
258594014966	DNA binding site [nucleotide binding]
258594014967	active site
258594014968	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
258594014969	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
258594014970	4 probable transmembrane helices predicted byTMHMM2.0
258594014971	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
258594014972	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594014973	N-terminal plug; other site
258594014974	ligand-binding site [chemical binding]; other site
258594014975	1 probable transmembrane helix predicted byTMHMM2.0
258594014976	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
258594014977	Peptidase family M23; Region: Peptidase_M23; pfam01551
258594014978	1 probable transmembrane helix predicted byTMHMM2.0
258594014979	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
258594014980	Strictosidine synthase; Region: Str_synth; pfam03088
258594014981	1 probable transmembrane helix predicted byTMHMM2.0
258594014982	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
258594014983	Clp amino terminal domain; Region: Clp_N; pfam02861
258594014984	Clp amino terminal domain; Region: Clp_N; pfam02861
258594014985	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594014986	Walker A motif; other site
258594014987	ATP binding site [chemical binding]; other site
258594014988	Walker B motif; other site
258594014989	arginine finger; other site
258594014990	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594014991	Walker A motif; other site
258594014992	ATP binding site [chemical binding]; other site
258594014993	Walker B motif; other site
258594014994	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
258594014995	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
258594014996	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
258594014997	MOSC domain; Region: MOSC; pfam03473
258594014998	TIGR02594 family protein; Region: TIGR02594
258594014999	1 probable transmembrane helix predicted byTMHMM2.0
258594015000	Methyltransferase domain; Region: Methyltransf_23; pfam13489
258594015001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594015002	S-adenosylmethionine binding site [chemical binding]; other site
258594015003	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
258594015004	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
258594015005	hypothetical protein; Provisional; Region: PRK06034
258594015006	Chorismate mutase type II; Region: CM_2; pfam01817
258594015007	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
258594015008	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
258594015009	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594015010	homodimer interface [polypeptide binding]; other site
258594015011	catalytic residue [active]
258594015012	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
258594015013	prephenate dehydrogenase; Validated; Region: PRK08507
258594015014	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
258594015015	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
258594015016	Cl binding site [ion binding]; other site
258594015017	oligomer interface [polypeptide binding]; other site
258594015018	2 probable transmembrane helices predicted byTMHMM2.0
258594015019	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
258594015020	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
258594015021	putative acyl-CoA synthetase; Provisional; Region: PRK06018
258594015022	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
258594015023	dimer interface [polypeptide binding]; other site
258594015024	acyl-activating enzyme (AAE) consensus motif; other site
258594015025	putative active site [active]
258594015026	AMP binding site [chemical binding]; other site
258594015027	putative CoA binding site [chemical binding]; other site
258594015028	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
258594015029	3 probable transmembrane helices predicted byTMHMM2.0
258594015030	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
258594015031	1 probable transmembrane helix predicted byTMHMM2.0
258594015032	Heavy-metal resistance; Region: Metal_resist; pfam13801
258594015033	1 probable transmembrane helix predicted byTMHMM2.0
258594015034	RNA polymerase sigma factor; Reviewed; Region: PRK05602
258594015035	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594015036	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
258594015037	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
258594015038	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
258594015039	dimerization interface [polypeptide binding]; other site
258594015040	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
258594015041	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594015042	dimer interface [polypeptide binding]; other site
258594015043	putative CheW interface [polypeptide binding]; other site
258594015044	2 probable transmembrane helices predicted byTMHMM2.0
258594015045	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
258594015046	tyrosine decarboxylase; Region: PLN02880
258594015047	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
258594015048	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594015049	catalytic residue [active]
258594015050	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
258594015051	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
258594015052	putative active site [active]
258594015053	metal binding site [ion binding]; metal-binding site
258594015054	homodimer binding site [polypeptide binding]; other site
258594015055	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
258594015056	1 probable transmembrane helix predicted byTMHMM2.0
258594015057	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
258594015058	active site
258594015059	catalytic residue [active]
258594015060	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
258594015061	3 probable transmembrane helices predicted byTMHMM2.0
258594015062	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
258594015063	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
258594015064	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
258594015065	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
258594015066	Cytochrome c; Region: Cytochrom_C; cl11414
258594015067	1 probable transmembrane helix predicted byTMHMM2.0
258594015068	Sulphur transport; Region: Sulf_transp; pfam04143
258594015069	9 probable transmembrane helices predicted byTMHMM2.0
258594015070	Cytochrome c; Region: Cytochrom_C; pfam00034
258594015071	bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113
258594015072	Moco binding site; other site
258594015073	metal coordination site [ion binding]; other site
258594015074	dimerization interface [polypeptide binding]; other site
258594015075	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
258594015076	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
258594015077	active site
258594015078	metal binding site [ion binding]; metal-binding site
258594015079	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
258594015080	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
258594015081	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
258594015082	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
258594015083	1 probable transmembrane helix predicted byTMHMM2.0
258594015084	Cytochrome c [Energy production and conversion]; Region: COG3258
258594015085	Cytochrome c; Region: Cytochrom_C; pfam00034
258594015086	Domain of unknown function (DUF336); Region: DUF336; cl01249
258594015087	SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951
258594015088	catalytic residues [active]
258594015089	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
258594015090	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
258594015091	6 probable transmembrane helices predicted byTMHMM2.0
258594015092	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
258594015093	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
258594015094	dimerization interface [polypeptide binding]; other site
258594015095	putative DNA binding site [nucleotide binding]; other site
258594015096	putative Zn2+ binding site [ion binding]; other site
258594015097	Sulphur transport; Region: Sulf_transp; pfam04143
258594015098	Sulphur transport; Region: Sulf_transp; pfam04143
258594015099	9 probable transmembrane helices predicted byTMHMM2.0
258594015100	DsrE/DsrF-like family; Region: DrsE; pfam02635
258594015101	1 probable transmembrane helix predicted byTMHMM2.0
258594015102	9 probable transmembrane helices predicted byTMHMM2.0
258594015103	Protein of unknown function (DUF3240); Region: DUF3240; pfam11582
258594015104	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
258594015105	12 probable transmembrane helices predicted byTMHMM2.0
258594015106	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
258594015107	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
258594015108	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594015109	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
258594015110	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594015111	dimer interface [polypeptide binding]; other site
258594015112	putative CheW interface [polypeptide binding]; other site
258594015113	1 probable transmembrane helix predicted byTMHMM2.0
258594015114	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594015115	PAS fold; Region: PAS_3; pfam08447
258594015116	putative active site [active]
258594015117	heme pocket [chemical binding]; other site
258594015118	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594015119	dimer interface [polypeptide binding]; other site
258594015120	putative CheW interface [polypeptide binding]; other site
258594015121	1 probable transmembrane helix predicted byTMHMM2.0
258594015122	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
258594015123	PAS fold; Region: PAS_3; pfam08447
258594015124	putative active site [active]
258594015125	heme pocket [chemical binding]; other site
258594015126	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
258594015127	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
258594015128	minor groove reading motif; other site
258594015129	helix-hairpin-helix signature motif; other site
258594015130	substrate binding pocket [chemical binding]; other site
258594015131	active site
258594015132	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
258594015133	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
258594015134	DNA binding and oxoG recognition site [nucleotide binding]
258594015135	Protein of unknown function (DUF721); Region: DUF721; cl02324
258594015136	Thioredoxin; Region: Thioredoxin_4; pfam13462
258594015137	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
258594015138	1 probable transmembrane helix predicted byTMHMM2.0
258594015139	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
258594015140	GIY-YIG motif/motif A; other site
258594015141	putative active site [active]
258594015142	putative metal binding site [ion binding]; other site
258594015143	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
258594015144	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
258594015145	Walker A/P-loop; other site
258594015146	ATP binding site [chemical binding]; other site
258594015147	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
258594015148	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
258594015149	ABC transporter signature motif; other site
258594015150	Walker B; other site
258594015151	D-loop; other site
258594015152	H-loop/switch region; other site
258594015153	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
258594015154	Autotransporter beta-domain; Region: Autotransporter; pfam03797
258594015155	1 probable transmembrane helix predicted byTMHMM2.0
258594015156	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
258594015157	active site
258594015158	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
258594015159	Peptidase family M48; Region: Peptidase_M48; cl12018
258594015160	4 probable transmembrane helices predicted byTMHMM2.0
258594015161	authentic frameshift, lemA pseudogene
258594015162	anthranilate synthase; Provisional; Region: PRK13566
258594015163	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
258594015164	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
258594015165	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
258594015166	glutamine binding [chemical binding]; other site
258594015167	catalytic triad [active]
258594015168	Protein of unknown function DUF86; Region: DUF86; cl01031
258594015169	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
258594015170	PhnA protein; Region: PhnA; pfam03831
258594015171	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
258594015172	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
258594015173	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
258594015174	acyl-activating enzyme (AAE) consensus motif; other site
258594015175	putative AMP binding site [chemical binding]; other site
258594015176	putative active site [active]
258594015177	putative CoA binding site [chemical binding]; other site
258594015178	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
258594015179	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
258594015180	classical (c) SDRs; Region: SDR_c; cd05233
258594015181	NAD(P) binding site [chemical binding]; other site
258594015182	active site
258594015183	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594015184	Radical SAM superfamily; Region: Radical_SAM; pfam04055
258594015185	FeS/SAM binding site; other site
258594015186	Domain of unknown function (DUF1850); Region: DUF1850; pfam08905
258594015187	1 probable transmembrane helix predicted byTMHMM2.0
258594015188	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
258594015189	DctM-like transporters; Region: DctM; pfam06808
258594015190	19 probable transmembrane helices predicted byTMHMM2.0
258594015191	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
258594015192	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
258594015193	11 probable transmembrane helices predicted byTMHMM2.0
258594015194	response regulator; Provisional; Region: PRK13435
258594015195	PAS fold; Region: PAS; pfam00989
258594015196	hypothetical protein; Provisional; Region: PRK13559
258594015197	HWE histidine kinase; Region: HWE_HK; smart00911
258594015198	PhoD-like phosphatase; Region: PhoD; pfam09423
258594015199	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
258594015200	putative active site [active]
258594015201	putative metal binding site [ion binding]; other site
258594015202	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
258594015203	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
258594015204	Response regulator receiver domain; Region: Response_reg; pfam00072
258594015205	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
258594015206	1 probable transmembrane helix predicted byTMHMM2.0
258594015207	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
258594015208	putative active site [active]
258594015209	putative CoA binding site [chemical binding]; other site
258594015210	nudix motif; other site
258594015211	metal binding site [ion binding]; metal-binding site
258594015212	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
258594015213	CoenzymeA binding site [chemical binding]; other site
258594015214	subunit interaction site [polypeptide binding]; other site
258594015215	PHB binding site; other site
258594015216	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
258594015217	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
258594015218	motif II; other site
258594015219	Response regulator receiver domain; Region: Response_reg; pfam00072
258594015220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594015221	active site
258594015222	phosphorylation site [posttranslational modification]
258594015223	intermolecular recognition site; other site
258594015224	dimerization interface [polypeptide binding]; other site
258594015225	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594015226	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594015227	ATP binding site [chemical binding]; other site
258594015228	Mg2+ binding site [ion binding]; other site
258594015229	G-X-G motif; other site
258594015230	7 probable transmembrane helices predicted byTMHMM2.0
258594015231	Maf-like protein; Region: Maf; pfam02545
258594015232	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
258594015233	active site
258594015234	dimer interface [polypeptide binding]; other site
258594015235	Predicted ATPase [General function prediction only]; Region: COG4637
258594015236	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594015237	Walker A/P-loop; other site
258594015238	ATP binding site [chemical binding]; other site
258594015239	Low molecular weight phosphatase family; Region: LMWPc; cd00115
258594015240	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
258594015241	active site
258594015242	hypothetical protein; Provisional; Region: PRK02853
258594015243	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
258594015244	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
258594015245	NAD binding site [chemical binding]; other site
258594015246	dimerization interface [polypeptide binding]; other site
258594015247	product binding site; other site
258594015248	substrate binding site [chemical binding]; other site
258594015249	zinc binding site [ion binding]; other site
258594015250	catalytic residues [active]
258594015251	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
258594015252	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
258594015253	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
258594015254	hinge; other site
258594015255	active site
258594015256	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
258594015257	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
258594015258	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
258594015259	ligand binding site [chemical binding]; other site
258594015260	flexible hinge region; other site
258594015261	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
258594015262	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
258594015263	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
258594015264	SnoaL-like domain; Region: SnoaL_2; pfam12680
258594015265	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
258594015266	multiple promoter invertase; Provisional; Region: mpi; PRK13413
258594015267	catalytic residues [active]
258594015268	catalytic nucleophile [active]
258594015269	Presynaptic Site I dimer interface [polypeptide binding]; other site
258594015270	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
258594015271	Synaptic Flat tetramer interface [polypeptide binding]; other site
258594015272	Synaptic Site I dimer interface [polypeptide binding]; other site
258594015273	DNA binding site [nucleotide binding]
258594015274	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
258594015275	DNA-binding interface [nucleotide binding]; DNA binding site
258594015276	Helix-turn-helix domain; Region: HTH_17; cl17695
258594015277	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
258594015278	nucleotide binding site [chemical binding]; other site
258594015279	AAA domain; Region: AAA_25; pfam13481
258594015280	Hexameric Replicative Helicase RepA.  RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125
258594015281	Walker A motif; other site
258594015282	NTP binding site [chemical binding]; other site
258594015283	hexamer interface [polypeptide binding]; other site
258594015284	Walker B motif; other site
258594015285	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
258594015286	active site
258594015287	catalytic residues [active]
258594015288	DNA binding site [nucleotide binding]
258594015289	Int/Topo IB signature motif; other site
258594015290	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
258594015291	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
258594015292	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
258594015293	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
258594015294	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
258594015295	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594015296	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594015297	active site
258594015298	DctM-like transporters; Region: DctM; pfam06808
258594015299	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
258594015300	11 probable transmembrane helices predicted byTMHMM2.0
258594015301	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
258594015302	4 probable transmembrane helices predicted byTMHMM2.0
258594015303	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
258594015304	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
258594015305	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
258594015306	CoA-transferase family III; Region: CoA_transf_3; pfam02515
258594015307	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
258594015308	putative active site [active]
258594015309	putative catalytic site [active]
258594015310	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
258594015311	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
258594015312	Transcriptional regulator [Transcription]; Region: IclR; COG1414
258594015313	Bacterial transcriptional regulator; Region: IclR; pfam01614
258594015314	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
258594015315	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
258594015316	active site
258594015317	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
258594015318	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
258594015319	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
258594015320	Staphylococcal nuclease homologues; Region: SNc; smart00318
258594015321	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
258594015322	Catalytic site; other site
258594015323	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
258594015324	CoenzymeA binding site [chemical binding]; other site
258594015325	subunit interaction site [polypeptide binding]; other site
258594015326	PHB binding site; other site
258594015327	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
258594015328	CoenzymeA binding site [chemical binding]; other site
258594015329	subunit interaction site [polypeptide binding]; other site
258594015330	PHB binding site; other site
258594015331	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
258594015332	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
258594015333	metal binding site [ion binding]; metal-binding site
258594015334	active site
258594015335	I-site; other site
258594015336	5 probable transmembrane helices predicted byTMHMM2.0
258594015337	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
258594015338	propionate/acetate kinase; Provisional; Region: PRK12379
258594015339	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
258594015340	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
258594015341	dimer interaction site [polypeptide binding]; other site
258594015342	substrate-binding tunnel; other site
258594015343	active site
258594015344	catalytic site [active]
258594015345	substrate binding site [chemical binding]; other site
258594015346	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
258594015347	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
258594015348	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
258594015349	NAD binding site [chemical binding]; other site
258594015350	homotetramer interface [polypeptide binding]; other site
258594015351	homodimer interface [polypeptide binding]; other site
258594015352	substrate binding site [chemical binding]; other site
258594015353	active site
258594015354	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
258594015355	9 probable transmembrane helices predicted byTMHMM2.0
258594015356	BA14K-like protein; Region: BA14K; pfam07886
258594015357	2 probable transmembrane helices predicted byTMHMM2.0
258594015358	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
258594015359	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
258594015360	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
258594015361	protein binding site [polypeptide binding]; other site
258594015362	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
258594015363	protein binding site [polypeptide binding]; other site
258594015364	1 probable transmembrane helix predicted byTMHMM2.0
258594015365	1 probable transmembrane helix predicted byTMHMM2.0
258594015366	3 probable transmembrane helices predicted byTMHMM2.0
258594015367	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
258594015368	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
258594015369	Walker A/P-loop; other site
258594015370	ATP binding site [chemical binding]; other site
258594015371	Q-loop/lid; other site
258594015372	ABC transporter signature motif; other site
258594015373	Walker B; other site
258594015374	D-loop; other site
258594015375	H-loop/switch region; other site
258594015376	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
258594015377	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
258594015378	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
258594015379	TM-ABC transporter signature motif; other site
258594015380	10 probable transmembrane helices predicted byTMHMM2.0
258594015381	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
258594015382	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
258594015383	TM-ABC transporter signature motif; other site
258594015384	9 probable transmembrane helices predicted byTMHMM2.0
258594015385	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
258594015386	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
258594015387	putative ligand binding site [chemical binding]; other site
258594015388	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
258594015389	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
258594015390	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
258594015391	protein binding site [polypeptide binding]; other site
258594015392	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
258594015393	12 probable transmembrane helices predicted byTMHMM2.0
258594015394	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
258594015395	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
258594015396	NAD binding site [chemical binding]; other site
258594015397	homodimer interface [polypeptide binding]; other site
258594015398	active site
258594015399	substrate binding site [chemical binding]; other site
258594015400	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
258594015401	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
258594015402	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
258594015403	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
258594015404	Chain length determinant protein; Region: Wzz; cl15801
258594015405	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
258594015406	2 probable transmembrane helices predicted byTMHMM2.0
258594015407	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
258594015408	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
258594015409	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
258594015410	4 probable transmembrane helices predicted byTMHMM2.0
258594015411	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
258594015412	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
258594015413	10 probable transmembrane helices predicted byTMHMM2.0
258594015414	homoserine O-succinyltransferase; Provisional; Region: PRK05368
258594015415	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
258594015416	conserved cys residue [active]
258594015417	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
258594015418	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
258594015419	homodimer interface [polypeptide binding]; other site
258594015420	substrate-cofactor binding pocket; other site
258594015421	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594015422	catalytic residue [active]
258594015423	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
258594015424	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
258594015425	acyl-activating enzyme (AAE) consensus motif; other site
258594015426	putative AMP binding site [chemical binding]; other site
258594015427	putative active site [active]
258594015428	putative CoA binding site [chemical binding]; other site
258594015429	aminotransferase; Provisional; Region: PRK13356
258594015430	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
258594015431	homodimer interface [polypeptide binding]; other site
258594015432	substrate-cofactor binding pocket; other site
258594015433	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594015434	catalytic residue [active]
258594015435	AMP-binding enzyme; Region: AMP-binding; pfam00501
258594015436	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594015437	acyl-activating enzyme (AAE) consensus motif; other site
258594015438	AMP binding site [chemical binding]; other site
258594015439	active site
258594015440	CoA binding site [chemical binding]; other site
258594015441	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
258594015442	classical (c) SDRs; Region: SDR_c; cd05233
258594015443	NAD(P) binding site [chemical binding]; other site
258594015444	active site
258594015445	Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670
258594015446	dimer interface [polypeptide binding]; other site
258594015447	motif 1; other site
258594015448	active site
258594015449	motif 2; other site
258594015450	motif 3; other site
258594015451	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
258594015452	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
258594015453	acyl carrier protein; Provisional; Region: PRK07081
258594015454	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
258594015455	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
258594015456	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
258594015457	oxidoreductase; Provisional; Region: PRK10015
258594015458	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
258594015459	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
258594015460	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
258594015461	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
258594015462	Ligand binding site [chemical binding]; other site
258594015463	Electron transfer flavoprotein domain; Region: ETF; pfam01012
258594015464	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810
258594015465	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
258594015466	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
258594015467	active site
258594015468	catalytic residues [active]
258594015469	metal binding site [ion binding]; metal-binding site
258594015470	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
258594015471	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
258594015472	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594015473	catalytic residue [active]
258594015474	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
258594015475	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
258594015476	active site
258594015477	trimerization site [polypeptide binding]; other site
258594015478	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
258594015479	NifU-like domain; Region: NifU; pfam01106
258594015480	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
258594015481	NifQ; Region: NifQ; pfam04891
258594015482	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
258594015483	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
258594015484	Rop-like; Region: Rop-like; pfam05082
258594015485	probable nitrogen fixation protein; Region: TIGR02935
258594015486	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
258594015487	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
258594015488	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
258594015489	nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478
258594015490	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
258594015491	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
258594015492	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
258594015493	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
258594015494	MoFe protein beta/alpha subunit interactions; other site
258594015495	Beta subunit P cluster binding residues; other site
258594015496	MoFe protein beta subunit/Fe protein contacts; other site
258594015497	MoFe protein dimer/ dimer interactions; other site
258594015498	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
258594015499	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
258594015500	MoFe protein alpha/beta subunit interactions; other site
258594015501	Alpha subunit P cluster binding residues; other site
258594015502	FeMoco binding residues [chemical binding]; other site
258594015503	MoFe protein alpha subunit/Fe protein contacts; other site
258594015504	MoFe protein dimer/ dimer interactions; other site
258594015505	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
258594015506	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
258594015507	Nucleotide-binding sites [chemical binding]; other site
258594015508	Walker A motif; other site
258594015509	Switch I region of nucleotide binding site; other site
258594015510	Fe4S4 binding sites [ion binding]; other site
258594015511	Switch II region of nucleotide binding site; other site
258594015512	SIR2-like domain; Region: SIR2_2; pfam13289
258594015513	NifT/FixU protein; Region: NifT; pfam06988
258594015514	NifZ domain; Region: NifZ; pfam04319
258594015515	NifZ domain; Region: NifZ; pfam04319
258594015516	LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484
258594015517	HEAT repeats; Region: HEAT_2; pfam13646
258594015518	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; pfam01521
258594015519	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
258594015520	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
258594015521	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
258594015522	FeS/SAM binding site; other site
258594015523	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
258594015524	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
258594015525	Nif-specific regulatory protein; Region: nifA; TIGR01817
258594015526	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
258594015527	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
258594015528	Walker A motif; other site
258594015529	ATP binding site [chemical binding]; other site
258594015530	Walker B motif; other site
258594015531	arginine finger; other site
258594015532	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
258594015533	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
258594015534	classical (c) SDRs; Region: SDR_c; cd05233
258594015535	NAD(P) binding site [chemical binding]; other site
258594015536	active site
258594015537	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
258594015538	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
258594015539	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
258594015540	G1 box; other site
258594015541	GTP/Mg2+ binding site [chemical binding]; other site
258594015542	Switch I region; other site
258594015543	G2 box; other site
258594015544	G3 box; other site
258594015545	Switch II region; other site
258594015546	G4 box; other site
258594015547	G5 box; other site
258594015548	Nucleoside recognition; Region: Gate; pfam07670
258594015549	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
258594015550	Nucleoside recognition; Region: Gate; pfam07670
258594015551	8 probable transmembrane helices predicted byTMHMM2.0
258594015552	FeoA domain; Region: FeoA; cl00838
258594015553	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
258594015554	HAMP domain; Region: HAMP; pfam00672
258594015555	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594015556	dimer interface [polypeptide binding]; other site
258594015557	putative CheW interface [polypeptide binding]; other site
258594015558	2 probable transmembrane helices predicted byTMHMM2.0
258594015559	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
258594015560	HAMP domain; Region: HAMP; pfam00672
258594015561	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594015562	dimer interface [polypeptide binding]; other site
258594015563	putative CheW interface [polypeptide binding]; other site
258594015564	2 probable transmembrane helices predicted byTMHMM2.0
258594015565	ribulose bisphosphate carboxylase; Provisional; Region: PRK13475
258594015566	Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211
258594015567	dimer interface [polypeptide binding]; other site
258594015568	active site
258594015569	catalytic residue [active]
258594015570	metal binding site [ion binding]; metal-binding site
258594015571	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
258594015572	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
258594015573	intersubunit interface [polypeptide binding]; other site
258594015574	active site
258594015575	zinc binding site [ion binding]; other site
258594015576	Na+ binding site [ion binding]; other site
258594015577	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
258594015578	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
258594015579	TPP-binding site [chemical binding]; other site
258594015580	dimer interface [polypeptide binding]; other site
258594015581	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
258594015582	PYR/PP interface [polypeptide binding]; other site
258594015583	dimer interface [polypeptide binding]; other site
258594015584	TPP binding site [chemical binding]; other site
258594015585	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
258594015586	phosphoribulokinase; Provisional; Region: PRK15453
258594015587	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
258594015588	metal binding site [ion binding]; metal-binding site
258594015589	active site
258594015590	Esterase/lipase [General function prediction only]; Region: COG1647
258594015591	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
258594015592	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
258594015593	Transcriptional regulator [Transcription]; Region: IclR; COG1414
258594015594	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
258594015595	Bacterial transcriptional regulator; Region: IclR; pfam01614
258594015596	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
258594015597	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
258594015598	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
258594015599	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594015600	dimer interface [polypeptide binding]; other site
258594015601	conserved gate region; other site
258594015602	putative PBP binding loops; other site
258594015603	ABC-ATPase subunit interface; other site
258594015604	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
258594015605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594015606	putative PBP binding loops; other site
258594015607	ABC-ATPase subunit interface; other site
258594015608	12 probable transmembrane helices predicted byTMHMM2.0
258594015609	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
258594015610	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
258594015611	Walker A/P-loop; other site
258594015612	ATP binding site [chemical binding]; other site
258594015613	Q-loop/lid; other site
258594015614	ABC transporter signature motif; other site
258594015615	Walker B; other site
258594015616	D-loop; other site
258594015617	H-loop/switch region; other site
258594015618	TOBE domain; Region: TOBE_2; pfam08402
258594015619	Coenzyme A transferase; Region: CoA_trans; smart00882
258594015620	Coenzyme A transferase; Region: CoA_trans; smart00882
258594015621	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
258594015622	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
258594015623	molybdopterin cofactor binding site [chemical binding]; other site
258594015624	substrate binding site [chemical binding]; other site
258594015625	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
258594015626	molybdopterin cofactor binding site; other site
258594015627	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
258594015628	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
258594015629	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
258594015630	intersubunit interface [polypeptide binding]; other site
258594015631	active site
258594015632	Zn2+ binding site [ion binding]; other site
258594015633	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
258594015634	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
258594015635	substrate binding site [chemical binding]; other site
258594015636	ATP binding site [chemical binding]; other site
258594015637	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
258594015638	classical (c) SDRs; Region: SDR_c; cd05233
258594015639	NAD(P) binding site [chemical binding]; other site
258594015640	active site
258594015641	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
258594015642	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
258594015643	NADP binding site [chemical binding]; other site
258594015644	dimer interface [polypeptide binding]; other site
258594015645	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
258594015646	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
258594015647	Coenzyme A binding pocket [chemical binding]; other site
258594015648	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
258594015649	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
258594015650	active site
258594015651	homotetramer interface [polypeptide binding]; other site
258594015652	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
258594015653	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
258594015654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594015655	putative substrate translocation pore; other site
258594015656	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
258594015657	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594015658	12 probable transmembrane helices predicted byTMHMM2.0
258594015659	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
258594015660	dimerization interface [polypeptide binding]; other site
258594015661	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594015662	dimer interface [polypeptide binding]; other site
258594015663	putative CheW interface [polypeptide binding]; other site
258594015664	2 probable transmembrane helices predicted byTMHMM2.0
258594015665	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
258594015666	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
258594015667	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594015668	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
258594015669	2-isopropylmalate synthase; Validated; Region: PRK03739
258594015670	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
258594015671	active site
258594015672	catalytic residues [active]
258594015673	metal binding site [ion binding]; metal-binding site
258594015674	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
258594015675	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
258594015676	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
258594015677	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
258594015678	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
258594015679	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
258594015680	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
258594015681	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
258594015682	FAD binding domain; Region: FAD_binding_4; pfam01565
258594015683	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
258594015684	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
258594015685	CoA-transferase family III; Region: CoA_transf_3; pfam02515
258594015686	fumarylacetoacetase; Region: PLN02856
258594015687	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
258594015688	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
258594015689	maleylacetoacetate isomerase; Region: maiA; TIGR01262
258594015690	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
258594015691	C-terminal domain interface [polypeptide binding]; other site
258594015692	GSH binding site (G-site) [chemical binding]; other site
258594015693	putative dimer interface [polypeptide binding]; other site
258594015694	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
258594015695	dimer interface [polypeptide binding]; other site
258594015696	N-terminal domain interface [polypeptide binding]; other site
258594015697	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
258594015698	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
258594015699	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
258594015700	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
258594015701	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
258594015702	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
258594015703	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
258594015704	MarR family; Region: MarR_2; pfam12802
258594015705	MarR family; Region: MarR_2; cl17246
258594015706	Caspase domain; Region: Peptidase_C14; pfam00656
258594015707	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594015708	binding surface
258594015709	TPR repeat; Region: TPR_11; pfam13414
258594015710	TPR motif; other site
258594015711	TPR repeat; Region: TPR_11; pfam13414
258594015712	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
258594015713	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
258594015714	ligand binding site [chemical binding]; other site
258594015715	1 probable transmembrane helix predicted byTMHMM2.0
258594015716	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
258594015717	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
258594015718	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594015719	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
258594015720	Domain of unknown function (DUF4358); Region: DUF4358; pfam14270
258594015721	Protein export membrane protein; Region: SecD_SecF; cl14618
258594015722	12 probable transmembrane helices predicted byTMHMM2.0
258594015723	AsmA family; Region: AsmA; pfam05170
258594015724	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
258594015725	1 probable transmembrane helix predicted byTMHMM2.0
258594015726	HlyD family secretion protein; Region: HlyD_3; pfam13437
258594015727	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
258594015728	2 probable transmembrane helices predicted byTMHMM2.0
258594015729	HAMP domain; Region: HAMP; pfam00672
258594015730	dimerization interface [polypeptide binding]; other site
258594015731	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
258594015732	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594015733	dimer interface [polypeptide binding]; other site
258594015734	putative CheW interface [polypeptide binding]; other site
258594015735	2 probable transmembrane helices predicted byTMHMM2.0
258594015736	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
258594015737	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
258594015738	active site
258594015739	nucleotide binding site [chemical binding]; other site
258594015740	HIGH motif; other site
258594015741	KMSKS motif; other site
258594015742	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
258594015743	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
258594015744	substrate binding pocket [chemical binding]; other site
258594015745	membrane-bound complex binding site; other site
258594015746	hinge residues; other site
258594015747	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
258594015748	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
258594015749	active site
258594015750	4 probable transmembrane helices predicted byTMHMM2.0
258594015751	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
258594015752	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
258594015753	Cu(I) binding site [ion binding]; other site
258594015754	1 probable transmembrane helix predicted byTMHMM2.0
258594015755	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
258594015756	HAMP domain; Region: HAMP; pfam00672
258594015757	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
258594015758	dimer interface [polypeptide binding]; other site
258594015759	putative CheW interface [polypeptide binding]; other site
258594015760	2 probable transmembrane helices predicted byTMHMM2.0
258594015761	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
258594015762	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
258594015763	active site
258594015764	FMN binding site [chemical binding]; other site
258594015765	substrate binding site [chemical binding]; other site
258594015766	homotetramer interface [polypeptide binding]; other site
258594015767	catalytic residue [active]
258594015768	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
258594015769	Transcriptional regulator [Transcription]; Region: LysR; COG0583
258594015770	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594015771	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
258594015772	putative dimerization interface [polypeptide binding]; other site
258594015773	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
258594015774	Amidohydrolase; Region: Amidohydro_2; pfam04909
258594015775	hypothetical protein; Provisional; Region: PRK09262
258594015776	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
258594015777	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826
258594015778	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
258594015779	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
258594015780	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
258594015781	active site
258594015782	The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924
258594015783	tetramer interface [polypeptide binding]; other site
258594015784	dimer interface [polypeptide binding]; other site
258594015785	active site
258594015786	Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364
258594015787	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
258594015788	active site
258594015789	Fe(II) binding site [ion binding]; other site
258594015790	dimer interface [polypeptide binding]; other site
258594015791	tetramer interface [polypeptide binding]; other site
258594015792	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
258594015793	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
258594015794	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
258594015795	1 probable transmembrane helix predicted byTMHMM2.0
258594015796	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
258594015797	metal binding site [ion binding]; metal-binding site
258594015798	Predicted membrane protein [Function unknown]; Region: COG1238
258594015799	3 probable transmembrane helices predicted byTMHMM2.0
258594015800	1 probable transmembrane helix predicted byTMHMM2.0
258594015801	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
258594015802	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
258594015803	FMN binding site [chemical binding]; other site
258594015804	substrate binding site [chemical binding]; other site
258594015805	putative catalytic residue [active]
258594015806	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
258594015807	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
258594015808	active site 2 [active]
258594015809	Predicted integral membrane protein [Function unknown]; Region: COG5616
258594015810	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594015811	TPR motif; other site
258594015812	binding surface
258594015813	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594015814	TPR motif; other site
258594015815	TPR repeat; Region: TPR_11; pfam13414
258594015816	binding surface
258594015817	Tetratricopeptide repeat; Region: TPR_16; pfam13432
258594015818	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
258594015819	binding surface
258594015820	TPR motif; other site
258594015821	Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476
258594015822	putative active site [active]
258594015823	putative catalytic triad [active]
258594015824	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
258594015825	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594015826	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
258594015827	Walker A/P-loop; other site
258594015828	ATP binding site [chemical binding]; other site
258594015829	Q-loop/lid; other site
258594015830	ABC transporter signature motif; other site
258594015831	Walker B; other site
258594015832	D-loop; other site
258594015833	H-loop/switch region; other site
258594015834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594015835	dimer interface [polypeptide binding]; other site
258594015836	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
258594015837	conserved gate region; other site
258594015838	putative PBP binding loops; other site
258594015839	ABC-ATPase subunit interface; other site
258594015840	5 probable transmembrane helices predicted byTMHMM2.0
258594015841	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
258594015842	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
258594015843	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
258594015844	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
258594015845	molybdenum-pterin binding domain; Region: Mop; TIGR00638
258594015846	TOBE domain; Region: TOBE; cl01440
258594015847	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
258594015848	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
258594015849	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674
258594015850	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
258594015851	dimer interface [polypeptide binding]; other site
258594015852	PYR/PP interface [polypeptide binding]; other site
258594015853	TPP binding site [chemical binding]; other site
258594015854	substrate binding site [chemical binding]; other site
258594015855	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
258594015856	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
258594015857	4Fe-4S binding domain; Region: Fer4_6; pfam12837
258594015858	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
258594015859	Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018
258594015860	dimer interface [polypeptide binding]; other site
258594015861	TPP-binding site [chemical binding]; other site
258594015862	putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Provisional; Region: PRK12779
258594015863	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
258594015864	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
258594015865	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
258594015866	FAD binding pocket [chemical binding]; other site
258594015867	FAD binding motif [chemical binding]; other site
258594015868	phosphate binding motif [ion binding]; other site
258594015869	beta-alpha-beta structure motif; other site
258594015870	NAD binding pocket [chemical binding]; other site
258594015871	Iron coordination center [ion binding]; other site
258594015872	5'-3' exonuclease; Region: 53EXOc; smart00475
258594015873	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
258594015874	active site
258594015875	metal binding site 1 [ion binding]; metal-binding site
258594015876	putative 5' ssDNA interaction site; other site
258594015877	metal binding site 3; metal-binding site
258594015878	metal binding site 2 [ion binding]; metal-binding site
258594015879	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
258594015880	putative DNA binding site [nucleotide binding]; other site
258594015881	putative metal binding site [ion binding]; other site
258594015882	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
258594015883	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
258594015884	active site
258594015885	catalytic site [active]
258594015886	substrate binding site [chemical binding]; other site
258594015887	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
258594015888	active site
258594015889	DNA binding site [nucleotide binding]
258594015890	catalytic site [active]
258594015891	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
258594015892	active site
258594015893	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
258594015894	1 probable transmembrane helix predicted byTMHMM2.0
258594015895	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
258594015896	homodimer interface [polypeptide binding]; other site
258594015897	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
258594015898	active site pocket [active]
258594015899	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
258594015900	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
258594015901	agmatinase; Region: agmatinase; TIGR01230
258594015902	Arginase family; Region: Arginase; cd09989
258594015903	active site
258594015904	Mn binding site [ion binding]; other site
258594015905	oligomer interface [polypeptide binding]; other site
258594015906	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
258594015907	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
258594015908	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
258594015909	ABC transporter; Region: ABC_tran_2; pfam12848
258594015910	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
258594015911	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
258594015912	1 probable transmembrane helix predicted byTMHMM2.0
258594015913	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
258594015914	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
258594015915	putative active site pocket [active]
258594015916	dimerization interface [polypeptide binding]; other site
258594015917	putative catalytic residue [active]
258594015918	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
258594015919	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
258594015920	putative acyl-acceptor binding pocket; other site
258594015921	1 probable transmembrane helix predicted byTMHMM2.0
258594015922	Uncharacterized conserved protein [Function unknown]; Region: COG1434
258594015923	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
258594015924	putative active site [active]
258594015925	1 probable transmembrane helix predicted byTMHMM2.0
258594015926	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
258594015927	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
258594015928	Walker A/P-loop; other site
258594015929	ATP binding site [chemical binding]; other site
258594015930	Q-loop/lid; other site
258594015931	ABC transporter signature motif; other site
258594015932	Walker B; other site
258594015933	D-loop; other site
258594015934	H-loop/switch region; other site
258594015935	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
258594015936	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
258594015937	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
258594015938	1 probable transmembrane helix predicted byTMHMM2.0
258594015939	Response regulator receiver domain; Region: Response_reg; pfam00072
258594015940	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594015941	active site
258594015942	phosphorylation site [posttranslational modification]
258594015943	intermolecular recognition site; other site
258594015944	dimerization interface [polypeptide binding]; other site
258594015945	TIGR02302 family protein; Region: aProt_lowcomp
258594015946	Pex19 protein family; Region: Pex19; pfam04614
258594015947	2 probable transmembrane helices predicted byTMHMM2.0
258594015948	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
258594015949	diaminopimelate decarboxylase; Region: lysA; TIGR01048
258594015950	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
258594015951	active site
258594015952	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
258594015953	substrate binding site [chemical binding]; other site
258594015954	catalytic residues [active]
258594015955	dimer interface [polypeptide binding]; other site
258594015956	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627
258594015957	argininosuccinate lyase; Provisional; Region: PRK00855
258594015958	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
258594015959	active sites [active]
258594015960	tetramer interface [polypeptide binding]; other site
258594015961	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
258594015962	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
258594015963	catalytic residues [active]
258594015964	1 probable transmembrane helix predicted byTMHMM2.0
258594015965	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
258594015966	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
258594015967	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
258594015968	LysR family transcriptional regulator; Provisional; Region: PRK14997
258594015969	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
258594015970	putative effector binding pocket; other site
258594015971	dimerization interface [polypeptide binding]; other site
258594015972	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
258594015973	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
258594015974	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
258594015975	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
258594015976	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
258594015977	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
258594015978	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
258594015979	Ligand binding site [chemical binding]; other site
258594015980	Electron transfer flavoprotein domain; Region: ETF; pfam01012
258594015981	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
258594015982	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
258594015983	6 probable transmembrane helices predicted byTMHMM2.0
258594015984	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594015985	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594015986	dimer interface [polypeptide binding]; other site
258594015987	phosphorylation site [posttranslational modification]
258594015988	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594015989	ATP binding site [chemical binding]; other site
258594015990	Mg2+ binding site [ion binding]; other site
258594015991	G-X-G motif; other site
258594015992	Response regulator receiver domain; Region: Response_reg; pfam00072
258594015993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594015994	active site
258594015995	phosphorylation site [posttranslational modification]
258594015996	intermolecular recognition site; other site
258594015997	dimerization interface [polypeptide binding]; other site
258594015998	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
258594015999	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
258594016000	active site
258594016001	HIGH motif; other site
258594016002	nucleotide binding site [chemical binding]; other site
258594016003	active site
258594016004	KMSKS motif; other site
258594016005	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
258594016006	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
258594016007	helix-hairpin-helix signature motif; other site
258594016008	active site
258594016009	nickel responsive regulator; Provisional; Region: PRK02967
258594016010	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
258594016011	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
258594016012	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
258594016013	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
258594016014	PRC-barrel domain; Region: PRC; pfam05239
258594016015	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
258594016016	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
258594016017	active site
258594016018	catalytic site [active]
258594016019	1 probable transmembrane helix predicted byTMHMM2.0
258594016020	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
258594016021	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
258594016022	DNA binding site [nucleotide binding]
258594016023	active site
258594016024	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148
258594016025	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
258594016026	12 probable transmembrane helices predicted byTMHMM2.0
258594016027	metallophosphoesterase, RPA4764 family; Region: RPA4764; TIGR03768
258594016028	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
258594016029	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
258594016030	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
258594016031	trimer interface [polypeptide binding]; other site
258594016032	active site
258594016033	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
258594016034	trimer interface [polypeptide binding]; other site
258594016035	active site
258594016036	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
258594016037	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
258594016038	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
258594016039	catalytic residue [active]
258594016040	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
258594016041	active site
258594016042	oxyanion hole [active]
258594016043	catalytic triad [active]
258594016044	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
258594016045	active site
258594016046	oxyanion hole [active]
258594016047	OpgC protein; Region: OpgC_C; pfam10129
258594016048	10 probable transmembrane helices predicted byTMHMM2.0
258594016049	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
258594016050	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
258594016051	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
258594016052	dimerization interface [polypeptide binding]; other site
258594016053	domain crossover interface; other site
258594016054	redox-dependent activation switch; other site
258594016055	ornithine carbamoyltransferase; Provisional; Region: PRK00779
258594016056	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
258594016057	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
258594016058	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
258594016059	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
258594016060	inhibitor-cofactor binding pocket; inhibition site
258594016061	pyridoxal 5'-phosphate binding site [chemical binding]; other site
258594016062	catalytic residue [active]
258594016063	GcrA cell cycle regulator; Region: GcrA; pfam07750
258594016064	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
258594016065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594016066	active site
258594016067	phosphorylation site [posttranslational modification]
258594016068	intermolecular recognition site; other site
258594016069	dimerization interface [polypeptide binding]; other site
258594016070	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
258594016071	DNA binding site [nucleotide binding]
258594016072	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
258594016073	PhoU domain; Region: PhoU; pfam01895
258594016074	PhoU domain; Region: PhoU; pfam01895
258594016075	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
258594016076	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
258594016077	Walker A/P-loop; other site
258594016078	ATP binding site [chemical binding]; other site
258594016079	Q-loop/lid; other site
258594016080	ABC transporter signature motif; other site
258594016081	Walker B; other site
258594016082	D-loop; other site
258594016083	H-loop/switch region; other site
258594016084	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
258594016085	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594016086	dimer interface [polypeptide binding]; other site
258594016087	conserved gate region; other site
258594016088	putative PBP binding loops; other site
258594016089	ABC-ATPase subunit interface; other site
258594016090	6 probable transmembrane helices predicted byTMHMM2.0
258594016091	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
258594016092	dimer interface [polypeptide binding]; other site
258594016093	conserved gate region; other site
258594016094	putative PBP binding loops; other site
258594016095	ABC-ATPase subunit interface; other site
258594016096	8 probable transmembrane helices predicted byTMHMM2.0
258594016097	PBP superfamily domain; Region: PBP_like_2; cl17296
258594016098	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
258594016099	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594016100	dimer interface [polypeptide binding]; other site
258594016101	phosphorylation site [posttranslational modification]
258594016102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594016103	ATP binding site [chemical binding]; other site
258594016104	Mg2+ binding site [ion binding]; other site
258594016105	G-X-G motif; other site
258594016106	1 probable transmembrane helix predicted byTMHMM2.0
258594016107	Predicted integral membrane protein [Function unknown]; Region: COG0392
258594016108	8 probable transmembrane helices predicted byTMHMM2.0
258594016109	3 probable transmembrane helices predicted byTMHMM2.0
258594016110	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
258594016111	ligand binding site [chemical binding]; other site
258594016112	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
258594016113	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
258594016114	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
258594016115	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
258594016116	putative active site [active]
258594016117	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
258594016118	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
258594016119	NAD(P) binding site [chemical binding]; other site
258594016120	active site
258594016121	anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154
258594016122	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
258594016123	non-specific DNA binding site [nucleotide binding]; other site
258594016124	salt bridge; other site
258594016125	sequence-specific DNA binding site [nucleotide binding]; other site
258594016126	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
258594016127	ADP binding site [chemical binding]; other site
258594016128	magnesium binding site [ion binding]; other site
258594016129	putative shikimate binding site; other site
258594016130	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
258594016131	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
258594016132	1 probable transmembrane helix predicted byTMHMM2.0
258594016133	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594016134	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
258594016135	dimerization interface [polypeptide binding]; other site
258594016136	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594016137	ATP binding site [chemical binding]; other site
258594016138	Mg2+ binding site [ion binding]; other site
258594016139	G-X-G motif; other site
258594016140	2 probable transmembrane helices predicted byTMHMM2.0
258594016141	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
258594016142	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
258594016143	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594016144	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
258594016145	dimer interface [polypeptide binding]; other site
258594016146	phosphorylation site [posttranslational modification]
258594016147	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594016148	ATP binding site [chemical binding]; other site
258594016149	Mg2+ binding site [ion binding]; other site
258594016150	G-X-G motif; other site
258594016151	osmolarity response regulator; Provisional; Region: ompR; PRK09468
258594016152	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594016153	active site
258594016154	phosphorylation site [posttranslational modification]
258594016155	intermolecular recognition site; other site
258594016156	dimerization interface [polypeptide binding]; other site
258594016157	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
258594016158	DNA binding site [nucleotide binding]
258594016159	RNA polymerase sigma factor; Provisional; Region: PRK12515
258594016160	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
258594016161	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
258594016162	DNA binding residues [nucleotide binding]
258594016163	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
258594016164	9 probable transmembrane helices predicted byTMHMM2.0
258594016165	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
258594016166	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
258594016167	8 probable transmembrane helices predicted byTMHMM2.0
258594016168	1 probable transmembrane helix predicted byTMHMM2.0
258594016169	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
258594016170	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
258594016171	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
258594016172	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
258594016173	substrate binding pocket [chemical binding]; other site
258594016174	membrane-bound complex binding site; other site
258594016175	hinge residues; other site
258594016176	1 probable transmembrane helix predicted byTMHMM2.0
258594016177	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
258594016178	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
258594016179	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
258594016180	active site
258594016181	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
258594016182	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
258594016183	active site
258594016184	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594016185	putative substrate translocation pore; other site
258594016186	Major Facilitator Superfamily; Region: MFS_1; pfam07690
258594016187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594016188	12 probable transmembrane helices predicted byTMHMM2.0
258594016189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594016190	Major Facilitator Superfamily; Region: MFS_1; pfam07690
258594016191	putative substrate translocation pore; other site
258594016192	12 probable transmembrane helices predicted byTMHMM2.0
258594016193	Protein of unknown function (DUF938); Region: DUF938; pfam06080
258594016194	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
258594016195	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
258594016196	N-terminal plug; other site
258594016197	ligand-binding site [chemical binding]; other site
258594016198	hypothetical protein; Provisional; Region: PRK06849
258594016199	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
258594016200	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
258594016201	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594016202	putative ligand binding site [chemical binding]; other site
258594016203	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
258594016204	D-galactonate transporter; Region: 2A0114; TIGR00893
258594016205	putative substrate translocation pore; other site
258594016206	12 probable transmembrane helices predicted byTMHMM2.0
258594016207	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
258594016208	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
258594016209	Walker A/P-loop; other site
258594016210	ATP binding site [chemical binding]; other site
258594016211	Q-loop/lid; other site
258594016212	ABC transporter signature motif; other site
258594016213	Walker B; other site
258594016214	D-loop; other site
258594016215	H-loop/switch region; other site
258594016216	FtsX-like permease family; Region: FtsX; pfam02687
258594016217	9 probable transmembrane helices predicted byTMHMM2.0
258594016218	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
258594016219	1 probable transmembrane helix predicted byTMHMM2.0
258594016220	MAPEG family; Region: MAPEG; pfam01124
258594016221	3 probable transmembrane helices predicted byTMHMM2.0
258594016222	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
258594016223	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
258594016224	putative ligand binding site [chemical binding]; other site
258594016225	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
258594016226	Omptin family; Region: Omptin; cl01886
258594016227	heat shock protein 90; Provisional; Region: PRK05218
258594016228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594016229	ATP binding site [chemical binding]; other site
258594016230	Mg2+ binding site [ion binding]; other site
258594016231	G-X-G motif; other site
258594016232	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
258594016233	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
258594016234	ATP binding site [chemical binding]; other site
258594016235	Mg2+ binding site [ion binding]; other site
258594016236	G-X-G motif; other site
258594016237	2 probable transmembrane helices predicted byTMHMM2.0
258594016238	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
258594016239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
258594016240	active site
258594016241	phosphorylation site [posttranslational modification]
258594016242	intermolecular recognition site; other site
258594016243	dimerization interface [polypeptide binding]; other site
258594016244	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
258594016245	DNA binding site [nucleotide binding]
258594016246	Predicted membrane protein [Function unknown]; Region: COG3212
258594016247	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
258594016248	1 probable transmembrane helix predicted byTMHMM2.0
258594016249	2 probable transmembrane helices predicted byTMHMM2.0
258594016250	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
258594016251	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
258594016252	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
258594016253	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
258594016254	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
258594016255	active site
258594016256	dimer interface [polypeptide binding]; other site
258594016257	metal binding site [ion binding]; metal-binding site
258594016258	acyl-CoA synthetase; Provisional; Region: PRK13391
258594016259	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
258594016260	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
258594016261	acyl-activating enzyme (AAE) consensus motif; other site
258594016262	acyl-activating enzyme (AAE) consensus motif; other site
258594016263	putative AMP binding site [chemical binding]; other site
258594016264	putative active site [active]
258594016265	putative CoA binding site [chemical binding]; other site
258594016266	EthD domain; Region: EthD; pfam07110
258594016267	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
258594016268	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
258594016269	DNA binding residues [nucleotide binding]
258594016270	putative dimer interface [polypeptide binding]; other site
258594016271	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
258594016272	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
258594016273	ATP binding site [chemical binding]; other site
258594016274	putative Mg++ binding site [ion binding]; other site
258594016275	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
258594016276	nucleotide binding region [chemical binding]; other site
258594016277	ATP-binding site [chemical binding]; other site
258594016278	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
258594016279	HRDC domain; Region: HRDC; pfam00570
258594016280	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
258594016281	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
258594016282	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
258594016283	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
258594016284	acyl-activating enzyme (AAE) consensus motif; other site
258594016285	putative AMP binding site [chemical binding]; other site
258594016286	putative active site [active]
258594016287	putative CoA binding site [chemical binding]; other site
258594016288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
258594016289	active site
258594016290	phosphorylation site [posttranslational modification]
258594016291	intermolecular recognition site; other site
258594016292	dimerization interface [polypeptide binding]; other site
258594016293	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
258594016294	Zn2+ binding site [ion binding]; other site
258594016295	Mg2+ binding site [ion binding]; other site
258594016296	2 probable transmembrane helices predicted byTMHMM2.0
258594016297	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
258594016298	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
258594016299	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
258594016300	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
258594016301	SLBB domain; Region: SLBB; pfam10531
258594016302	1 probable transmembrane helix predicted byTMHMM2.0
258594016303	methionine sulfoxide reductase A; Provisional; Region: PRK00058
258594016304	2 probable transmembrane helices predicted byTMHMM2.0
258594016305	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
258594016306	Replication initiator protein A; Region: RPA; pfam10134
258594016307	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
258594016308	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
258594016309	Magnesium ion binding site [ion binding]; other site
258594016310	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
258594016311	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
258594016312	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
258594016313	S-adenosylmethionine binding site [chemical binding]; other site
258594016314	multiple promoter invertase; Provisional; Region: mpi; PRK13413
258594016315	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
258594016316	catalytic residues [active]
258594016317	catalytic nucleophile [active]
258594016318	Presynaptic Site I dimer interface [polypeptide binding]; other site
258594016319	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
258594016320	Synaptic Flat tetramer interface [polypeptide binding]; other site
258594016321	Synaptic Site I dimer interface [polypeptide binding]; other site
258594016322	DNA binding site [nucleotide binding]
258594016323	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
258594016324	DNA-binding interface [nucleotide binding]; DNA binding site
258594016325	Polyhedrin; Region: Polyhedrin; cl17403