-- dump date 20140620_033055 -- class Genbank::misc_feature -- table misc_feature_note -- id note 269796000001 ParA-like protein; Provisional; Region: PHA02518 269796000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 269796000003 P-loop; other site 269796000004 Magnesium ion binding site [ion binding]; other site 269796000005 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796000006 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796000007 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 269796000008 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269796000009 active site 269796000010 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796000011 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796000012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269796000013 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 269796000014 NAD(P) binding site [chemical binding]; other site 269796000015 active site 269796000016 Methyltransferase domain; Region: Methyltransf_24; pfam13578 269796000017 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796000018 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796000019 Rhamnan synthesis protein F; Region: RgpF; pfam05045 269796000020 Transposase, Mutator family; Region: Transposase_mut; cl19537 269796000021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 269796000022 Transposase, Mutator family; Region: Transposase_mut; cl19537 269796000023 multiple promoter invertase; Provisional; Region: mpi; PRK13413 269796000024 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 269796000025 catalytic residues [active] 269796000026 catalytic nucleophile [active] 269796000027 Presynaptic Site I dimer interface [polypeptide binding]; other site 269796000028 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 269796000029 Synaptic Flat tetramer interface [polypeptide binding]; other site 269796000030 Synaptic Site I dimer interface [polypeptide binding]; other site 269796000031 DNA binding site [nucleotide binding] 269796000032 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 269796000033 DNA-binding interface [nucleotide binding]; DNA binding site 269796000034 Protein of unknown function DUF86; Region: DUF86; cl01031 269796000035 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 269796000036 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 269796000037 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 269796000038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 269796000039 Transposase, Mutator family; Region: Transposase_mut; cl19537 269796000040 Transposase, Mutator family; Region: Transposase_mut; cl19537 269796000041 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 269796000042 active site 269796000043 Int/Topo IB signature motif; other site 269796000044 DNA binding site [nucleotide binding] 269796000045 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796000046 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796000047 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 269796000048 putative substrate binding pocket [chemical binding]; other site 269796000049 putative dimerization interface [polypeptide binding]; other site 269796000050 Predicted membrane protein [Function unknown]; Region: COG2364 269796000051 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 269796000052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796000053 S-adenosylmethionine binding site [chemical binding]; other site 269796000054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796000055 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796000056 putative substrate translocation pore; other site 269796000057 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 269796000058 DNA-binding interface [nucleotide binding]; DNA binding site 269796000059 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 269796000060 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 269796000061 catalytic residues [active] 269796000062 catalytic nucleophile [active] 269796000063 Presynaptic Site I dimer interface [polypeptide binding]; other site 269796000064 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 269796000065 Synaptic Flat tetramer interface [polypeptide binding]; other site 269796000066 Synaptic Site I dimer interface [polypeptide binding]; other site 269796000067 DNA binding site [nucleotide binding] 269796000068 Replication initiator protein A; Region: RPA; pfam10134 269796000069 SapC; Region: SapC; pfam07277 269796000070 ABC-2 type transporter; Region: ABC2_membrane; cl17235 269796000071 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 269796000072 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 269796000073 Walker A/P-loop; other site 269796000074 ATP binding site [chemical binding]; other site 269796000075 Q-loop/lid; other site 269796000076 ABC transporter signature motif; other site 269796000077 Walker B; other site 269796000078 D-loop; other site 269796000079 H-loop/switch region; other site 269796000080 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 269796000081 putative carbohydrate binding site [chemical binding]; other site 269796000082 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 269796000083 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 269796000084 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 269796000085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796000086 S-adenosylmethionine binding site [chemical binding]; other site 269796000087 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 269796000088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 269796000089 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 269796000090 Fic/DOC family; Region: Fic; cl00960 269796000091 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 269796000092 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 269796000093 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 269796000094 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269796000095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796000096 Walker A/P-loop; other site 269796000097 ATP binding site [chemical binding]; other site 269796000098 Q-loop/lid; other site 269796000099 ABC transporter signature motif; other site 269796000100 Walker B; other site 269796000101 D-loop; other site 269796000102 H-loop/switch region; other site 269796000103 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 269796000104 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 269796000105 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796000106 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269796000107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796000108 non-specific DNA binding site [nucleotide binding]; other site 269796000109 salt bridge; other site 269796000110 sequence-specific DNA binding site [nucleotide binding]; other site 269796000111 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 269796000112 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269796000113 active site 269796000114 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796000115 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796000116 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 269796000117 active site 269796000118 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 269796000119 substrate binding site [chemical binding]; other site 269796000120 metal binding site [ion binding]; metal-binding site 269796000121 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 269796000122 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 269796000123 Substrate binding site; other site 269796000124 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 269796000125 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 269796000126 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 269796000127 NADP-binding site; other site 269796000128 homotetramer interface [polypeptide binding]; other site 269796000129 substrate binding site [chemical binding]; other site 269796000130 homodimer interface [polypeptide binding]; other site 269796000131 active site 269796000132 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 269796000133 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 269796000134 substrate binding site; other site 269796000135 tetramer interface; other site 269796000136 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 269796000137 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 269796000138 NADP binding site [chemical binding]; other site 269796000139 active site 269796000140 putative substrate binding site [chemical binding]; other site 269796000141 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 269796000142 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 269796000143 NAD binding site [chemical binding]; other site 269796000144 substrate binding site [chemical binding]; other site 269796000145 homodimer interface [polypeptide binding]; other site 269796000146 active site 269796000147 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 269796000148 DnaA N-terminal domain; Region: DnaA_N; pfam11638 269796000149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796000150 Walker A motif; other site 269796000151 ATP binding site [chemical binding]; other site 269796000152 Walker B motif; other site 269796000153 arginine finger; other site 269796000154 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 269796000155 DnaA box-binding interface [nucleotide binding]; other site 269796000156 DNA polymerase III subunit beta; Validated; Region: PRK05643 269796000157 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 269796000158 putative DNA binding surface [nucleotide binding]; other site 269796000159 dimer interface [polypeptide binding]; other site 269796000160 beta-clamp/clamp loader binding surface; other site 269796000161 beta-clamp/translesion DNA polymerase binding surface; other site 269796000162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796000163 recombination protein F; Reviewed; Region: recF; PRK00064 269796000164 Walker A/P-loop; other site 269796000165 ATP binding site [chemical binding]; other site 269796000166 Q-loop/lid; other site 269796000167 ABC transporter signature motif; other site 269796000168 Walker B; other site 269796000169 D-loop; other site 269796000170 H-loop/switch region; other site 269796000171 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 269796000172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796000173 ATP binding site [chemical binding]; other site 269796000174 Mg2+ binding site [ion binding]; other site 269796000175 G-X-G motif; other site 269796000176 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 269796000177 anchoring element; other site 269796000178 dimer interface [polypeptide binding]; other site 269796000179 ATP binding site [chemical binding]; other site 269796000180 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 269796000181 active site 269796000182 putative metal-binding site [ion binding]; other site 269796000183 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 269796000184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796000185 non-specific DNA binding site [nucleotide binding]; other site 269796000186 salt bridge; other site 269796000187 sequence-specific DNA binding site [nucleotide binding]; other site 269796000188 Domain of unknown function (DUF955); Region: DUF955; pfam06114 269796000189 ZIP Zinc transporter; Region: Zip; cl00437 269796000190 High-affinity nickel-transport protein; Region: NicO; cl00964 269796000191 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 269796000192 active site 269796000193 phosphorylation site [posttranslational modification] 269796000194 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 269796000195 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 269796000196 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 269796000197 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 269796000198 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 269796000199 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 269796000200 Walker A/P-loop; other site 269796000201 ATP binding site [chemical binding]; other site 269796000202 Q-loop/lid; other site 269796000203 ABC transporter signature motif; other site 269796000204 Walker B; other site 269796000205 D-loop; other site 269796000206 H-loop/switch region; other site 269796000207 OstA-like protein; Region: OstA; cl00844 269796000208 Lipopolysaccharide-assembly, LptC-related; Region: LptC; cl01200 269796000209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 269796000210 KpsF/GutQ family protein; Region: kpsF; TIGR00393 269796000211 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 269796000212 putative active site [active] 269796000213 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 269796000214 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 269796000215 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 269796000216 catalytic site [active] 269796000217 putative active site [active] 269796000218 putative substrate binding site [chemical binding]; other site 269796000219 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 269796000220 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 269796000221 putative NAD(P) binding site [chemical binding]; other site 269796000222 active site 269796000223 Bacitracin resistance protein BacA; Region: BacA; pfam02673 269796000224 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 269796000225 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 269796000226 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796000227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269796000228 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 269796000229 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 269796000230 active site 269796000231 dimer interface [polypeptide binding]; other site 269796000232 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 269796000233 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 269796000234 active site 269796000235 FMN binding site [chemical binding]; other site 269796000236 substrate binding site [chemical binding]; other site 269796000237 3Fe-4S cluster binding site [ion binding]; other site 269796000238 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 269796000239 domain interface; other site 269796000240 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 269796000241 catalytic residues [active] 269796000242 dimer interface [polypeptide binding]; other site 269796000243 Transcriptional regulators [Transcription]; Region: MarR; COG1846 269796000244 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 269796000245 putative DNA binding site [nucleotide binding]; other site 269796000246 putative Zn2+ binding site [ion binding]; other site 269796000247 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 269796000248 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 269796000249 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 269796000250 N-terminal domain interface [polypeptide binding]; other site 269796000251 dimer interface [polypeptide binding]; other site 269796000252 substrate binding pocket (H-site) [chemical binding]; other site 269796000253 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 269796000254 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269796000255 protein binding site [polypeptide binding]; other site 269796000256 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 269796000257 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 269796000258 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 269796000259 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 269796000260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796000261 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 269796000262 dimerization interface [polypeptide binding]; other site 269796000263 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 269796000264 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 269796000265 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 269796000266 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 269796000267 catalytic residues [active] 269796000268 central insert; other site 269796000269 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 269796000270 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 269796000271 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 269796000272 heme exporter protein CcmC; Region: ccmC; TIGR01191 269796000273 heme exporter protein CcmB; Region: ccmB; TIGR01190 269796000274 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 269796000275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796000276 Walker A/P-loop; other site 269796000277 ATP binding site [chemical binding]; other site 269796000278 Q-loop/lid; other site 269796000279 ABC transporter signature motif; other site 269796000280 Walker B; other site 269796000281 D-loop; other site 269796000282 H-loop/switch region; other site 269796000283 Cytochrome C' Region: Cytochrom_C_2; pfam01322 269796000284 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 269796000285 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 269796000286 trimer interface [polypeptide binding]; other site 269796000287 active site 269796000288 UDP-GlcNAc binding site [chemical binding]; other site 269796000289 lipid binding site [chemical binding]; lipid-binding site 269796000290 acyl carrier protein; Provisional; Region: acpP; PRK00982 269796000291 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 269796000292 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 269796000293 dimer interface [polypeptide binding]; other site 269796000294 active site 269796000295 Uncharacterized conserved protein [Function unknown]; Region: COG1683 269796000296 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 269796000297 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269796000298 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193 269796000299 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269796000300 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 269796000301 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 269796000302 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 269796000303 carboxyltransferase (CT) interaction site; other site 269796000304 biotinylation site [posttranslational modification]; other site 269796000305 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 269796000306 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 269796000307 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 269796000308 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 269796000309 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269796000310 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269796000311 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 269796000312 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 269796000313 carboxyltransferase (CT) interaction site; other site 269796000314 biotinylation site [posttranslational modification]; other site 269796000315 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 269796000316 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 269796000317 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 269796000318 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 269796000319 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 269796000320 TPP-binding site; other site 269796000321 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 269796000322 PYR/PP interface [polypeptide binding]; other site 269796000323 dimer interface [polypeptide binding]; other site 269796000324 TPP binding site [chemical binding]; other site 269796000325 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 269796000326 VacJ like lipoprotein; Region: VacJ; cl01073 269796000327 hopanoid biosynthesis associated membrane protein HpnM; Region: HpnM; TIGR03481 269796000328 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 269796000329 MMPL family; Region: MMPL; cl14618 269796000330 MMPL family; Region: MMPL; cl14618 269796000331 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 269796000332 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 269796000333 putative NADP binding site [chemical binding]; other site 269796000334 putative substrate binding site [chemical binding]; other site 269796000335 active site 269796000336 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 269796000337 Fe-S cluster binding site [ion binding]; other site 269796000338 substrate binding site [chemical binding]; other site 269796000339 catalytic site [active] 269796000340 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 269796000341 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796000342 FeS/SAM binding site; other site 269796000343 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 269796000344 hopanoid-associated phosphorylase; Region: HpnG; TIGR03468 269796000345 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 269796000346 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 269796000347 Active site cavity [active] 269796000348 catalytic acid [active] 269796000349 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 269796000350 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 269796000351 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 269796000352 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269796000353 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 269796000354 active site lid residues [active] 269796000355 substrate binding pocket [chemical binding]; other site 269796000356 catalytic residues [active] 269796000357 substrate-Mg2+ binding site; other site 269796000358 aspartate-rich region 1; other site 269796000359 aspartate-rich region 2; other site 269796000360 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 269796000361 active site lid residues [active] 269796000362 substrate binding pocket [chemical binding]; other site 269796000363 catalytic residues [active] 269796000364 substrate-Mg2+ binding site; other site 269796000365 aspartate-rich region 1; other site 269796000366 aspartate-rich region 2; other site 269796000367 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 269796000368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796000369 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 269796000370 putative active site [active] 269796000371 heme pocket [chemical binding]; other site 269796000372 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796000373 putative active site [active] 269796000374 heme pocket [chemical binding]; other site 269796000375 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796000376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796000377 dimer interface [polypeptide binding]; other site 269796000378 phosphorylation site [posttranslational modification] 269796000379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796000380 ATP binding site [chemical binding]; other site 269796000381 Mg2+ binding site [ion binding]; other site 269796000382 G-X-G motif; other site 269796000383 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 269796000384 GIY-YIG motif/motif A; other site 269796000385 putative active site [active] 269796000386 putative metal binding site [ion binding]; other site 269796000387 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 269796000388 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 269796000389 hypothetical protein; Provisional; Region: PHA02695 269796000390 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 269796000391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796000392 Walker A/P-loop; other site 269796000393 ATP binding site [chemical binding]; other site 269796000394 Q-loop/lid; other site 269796000395 ABC transporter signature motif; other site 269796000396 Walker B; other site 269796000397 D-loop; other site 269796000398 H-loop/switch region; other site 269796000399 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796000400 EamA-like transporter family; Region: EamA; pfam00892 269796000401 EamA-like transporter family; Region: EamA; pfam00892 269796000402 heat shock protein 90; Provisional; Region: PRK05218 269796000403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796000404 ATP binding site [chemical binding]; other site 269796000405 Mg2+ binding site [ion binding]; other site 269796000406 G-X-G motif; other site 269796000407 Hsp90 protein; Region: HSP90; pfam00183 269796000408 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 269796000409 30S subunit binding site; other site 269796000410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269796000411 nucleotide binding region [chemical binding]; other site 269796000412 ATP-binding site [chemical binding]; other site 269796000413 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269796000414 RNA binding surface [nucleotide binding]; other site 269796000415 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 269796000416 putative metal binding site [ion binding]; other site 269796000417 Ferredoxin [Energy production and conversion]; Region: COG1146 269796000418 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 269796000419 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 269796000420 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 269796000421 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796000422 putative CheW interface [polypeptide binding]; other site 269796000423 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796000424 putative CheW interface [polypeptide binding]; other site 269796000425 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796000426 putative CheW interface [polypeptide binding]; other site 269796000427 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 269796000428 Putative lysophospholipase; Region: Hydrolase_4; cl19140 269796000429 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 269796000430 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269796000431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796000432 active site 269796000433 phosphorylation site [posttranslational modification] 269796000434 intermolecular recognition site; other site 269796000435 dimerization interface [polypeptide binding]; other site 269796000436 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796000437 metal binding site [ion binding]; metal-binding site 269796000438 active site 269796000439 I-site; other site 269796000440 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 269796000441 HI0933-like protein; Region: HI0933_like; pfam03486 269796000442 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796000443 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796000444 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 269796000445 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 269796000446 putative NAD(P) binding site [chemical binding]; other site 269796000447 dimer interface [polypeptide binding]; other site 269796000448 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 269796000449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269796000450 ATP binding site [chemical binding]; other site 269796000451 putative Mg++ binding site [ion binding]; other site 269796000452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269796000453 nucleotide binding region [chemical binding]; other site 269796000454 ATP-binding site [chemical binding]; other site 269796000455 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 269796000456 HRDC domain; Region: HRDC; pfam00570 269796000457 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 269796000458 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 269796000459 oligomeric interface; other site 269796000460 putative active site [active] 269796000461 homodimer interface [polypeptide binding]; other site 269796000462 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 269796000463 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 269796000464 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 269796000465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796000466 dimer interface [polypeptide binding]; other site 269796000467 conserved gate region; other site 269796000468 putative PBP binding loops; other site 269796000469 ABC-ATPase subunit interface; other site 269796000470 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 269796000471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796000472 dimer interface [polypeptide binding]; other site 269796000473 conserved gate region; other site 269796000474 putative PBP binding loops; other site 269796000475 ABC-ATPase subunit interface; other site 269796000476 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 269796000477 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 269796000478 Walker A/P-loop; other site 269796000479 ATP binding site [chemical binding]; other site 269796000480 Q-loop/lid; other site 269796000481 ABC transporter signature motif; other site 269796000482 Walker B; other site 269796000483 D-loop; other site 269796000484 H-loop/switch region; other site 269796000485 TOBE domain; Region: TOBE; pfam03459 269796000486 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 269796000487 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269796000488 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796000489 hypothetical protein; Provisional; Region: PRK09256 269796000490 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 269796000491 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 269796000492 homodimer interface [polypeptide binding]; other site 269796000493 substrate-cofactor binding pocket; other site 269796000494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796000495 catalytic residue [active] 269796000496 HAMP domain; Region: HAMP; pfam00672 269796000497 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 269796000498 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 269796000499 Uncharacterized conserved protein [Function unknown]; Region: COG5439 269796000500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 269796000501 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796000502 metal binding site [ion binding]; metal-binding site 269796000503 active site 269796000504 I-site; other site 269796000505 SlyX; Region: SlyX; pfam04102 269796000506 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 269796000507 MG2 domain; Region: A2M_N; pfam01835 269796000508 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 269796000509 Alpha-2-macroglobulin family; Region: A2M; pfam00207 269796000510 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 269796000511 surface patch; other site 269796000512 thioester region; other site 269796000513 specificity defining residues; other site 269796000514 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 269796000515 Transglycosylase; Region: Transgly; pfam00912 269796000516 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 269796000517 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 269796000518 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796000519 binding surface 269796000520 TPR motif; other site 269796000521 AAA domain; Region: AAA_22; pfam13401 269796000522 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 269796000523 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 269796000524 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 269796000525 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 269796000526 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 269796000527 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 269796000528 Walker A motif; other site 269796000529 ATP binding site [chemical binding]; other site 269796000530 Walker B motif; other site 269796000531 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 269796000532 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 269796000533 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 269796000534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796000535 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 269796000536 Walker A/P-loop; other site 269796000537 ATP binding site [chemical binding]; other site 269796000538 Q-loop/lid; other site 269796000539 ABC transporter signature motif; other site 269796000540 Walker B; other site 269796000541 D-loop; other site 269796000542 H-loop/switch region; other site 269796000543 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 269796000544 Walker A motif; other site 269796000545 ATP binding site [chemical binding]; other site 269796000546 Walker B motif; other site 269796000547 Protoglobin; Region: Protoglobin; pfam11563 269796000548 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796000549 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796000550 dimer interface [polypeptide binding]; other site 269796000551 putative CheW interface [polypeptide binding]; other site 269796000552 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 269796000553 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 269796000554 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 269796000555 putative ribose interaction site [chemical binding]; other site 269796000556 putative ADP binding site [chemical binding]; other site 269796000557 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 269796000558 active site 269796000559 nucleotide binding site [chemical binding]; other site 269796000560 HIGH motif; other site 269796000561 KMSKS motif; other site 269796000562 EAL domain; Region: EAL; pfam00563 269796000563 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 269796000564 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 269796000565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796000566 Walker A/P-loop; other site 269796000567 ATP binding site [chemical binding]; other site 269796000568 Q-loop/lid; other site 269796000569 ABC transporter signature motif; other site 269796000570 Walker B; other site 269796000571 D-loop; other site 269796000572 H-loop/switch region; other site 269796000573 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 269796000574 ABC-2 type transporter; Region: ABC2_membrane; cl17235 269796000575 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 269796000576 PAS fold; Region: PAS_3; pfam08447 269796000577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796000578 putative active site [active] 269796000579 heme pocket [chemical binding]; other site 269796000580 PAS fold; Region: PAS_3; pfam08447 269796000581 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796000582 putative active site [active] 269796000583 heme pocket [chemical binding]; other site 269796000584 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796000585 dimer interface [polypeptide binding]; other site 269796000586 putative CheW interface [polypeptide binding]; other site 269796000587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 269796000588 active site 269796000589 phosphorylation site [posttranslational modification] 269796000590 intermolecular recognition site; other site 269796000591 dimerization interface [polypeptide binding]; other site 269796000592 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 269796000593 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 269796000594 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796000595 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 269796000596 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 269796000597 tetramerization interface [polypeptide binding]; other site 269796000598 NAD(P) binding site [chemical binding]; other site 269796000599 catalytic residues [active] 269796000600 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 269796000601 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796000602 EamA-like transporter family; Region: EamA; pfam00892 269796000603 EamA-like transporter family; Region: EamA; pfam00892 269796000604 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 269796000605 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 269796000606 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 269796000607 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 269796000608 interface (dimer of trimers) [polypeptide binding]; other site 269796000609 Substrate-binding/catalytic site; other site 269796000610 Zn-binding sites [ion binding]; other site 269796000611 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 269796000612 Transcriptional regulators [Transcription]; Region: MarR; COG1846 269796000613 Cupin domain; Region: Cupin_2; cl17218 269796000614 Helix-turn-helix domain; Region: HTH_18; pfam12833 269796000615 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 269796000616 dimer interface [polypeptide binding]; other site 269796000617 active site 269796000618 Schiff base residues; other site 269796000619 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 269796000620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269796000621 Coenzyme A binding pocket [chemical binding]; other site 269796000622 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 269796000623 active site 269796000624 FMN binding site [chemical binding]; other site 269796000625 substrate binding site [chemical binding]; other site 269796000626 homotetramer interface [polypeptide binding]; other site 269796000627 catalytic residue [active] 269796000628 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796000629 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796000630 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 269796000631 dimer interface [polypeptide binding]; other site 269796000632 substrate binding site [chemical binding]; other site 269796000633 metal binding sites [ion binding]; metal-binding site 269796000634 muropeptide transporter; Reviewed; Region: ampG; cl17669 269796000635 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 269796000636 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 269796000637 G1 box; other site 269796000638 putative GEF interaction site [polypeptide binding]; other site 269796000639 GTP/Mg2+ binding site [chemical binding]; other site 269796000640 Switch I region; other site 269796000641 G2 box; other site 269796000642 G3 box; other site 269796000643 Switch II region; other site 269796000644 G4 box; other site 269796000645 G5 box; other site 269796000646 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 269796000647 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 269796000648 adenosine kinase; Provisional; Region: PTZ00247 269796000649 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 269796000650 substrate binding site [chemical binding]; other site 269796000651 ATP binding site [chemical binding]; other site 269796000652 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 269796000653 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 269796000654 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 269796000655 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 269796000656 minor groove reading motif; other site 269796000657 helix-hairpin-helix signature motif; other site 269796000658 substrate binding pocket [chemical binding]; other site 269796000659 active site 269796000660 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 269796000661 dihydrodipicolinate reductase; Provisional; Region: PRK00048 269796000662 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 269796000663 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 269796000664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796000665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796000666 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 269796000667 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 269796000668 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269796000669 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796000670 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 269796000671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796000672 putative substrate translocation pore; other site 269796000673 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269796000674 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796000675 dimerization interface [polypeptide binding]; other site 269796000676 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796000677 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796000678 dimer interface [polypeptide binding]; other site 269796000679 putative CheW interface [polypeptide binding]; other site 269796000680 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 269796000681 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 269796000682 generic binding surface II; other site 269796000683 generic binding surface I; other site 269796000684 Usg-like family; Region: Usg; pfam06233 269796000685 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 269796000686 oligomerisation interface [polypeptide binding]; other site 269796000687 mobile loop; other site 269796000688 roof hairpin; other site 269796000689 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 269796000690 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 269796000691 ring oligomerisation interface [polypeptide binding]; other site 269796000692 ATP/Mg binding site [chemical binding]; other site 269796000693 stacking interactions; other site 269796000694 hinge regions; other site 269796000695 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269796000696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796000697 non-specific DNA binding site [nucleotide binding]; other site 269796000698 salt bridge; other site 269796000699 sequence-specific DNA binding site [nucleotide binding]; other site 269796000700 putative transporter; Provisional; Region: PRK11660 269796000701 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 269796000702 Sulfate transporter family; Region: Sulfate_transp; pfam00916 269796000703 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 269796000704 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 269796000705 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 269796000706 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 269796000707 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 269796000708 CT1975-like protein; Region: Cas_CT1975; pfam09344 269796000709 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 269796000710 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 269796000711 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 269796000712 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 269796000713 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 269796000714 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 269796000715 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 269796000716 inhibitor-cofactor binding pocket; inhibition site 269796000717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796000718 catalytic residue [active] 269796000719 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 269796000720 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 269796000721 N-acetyl-D-glucosamine binding site [chemical binding]; other site 269796000722 catalytic residue [active] 269796000723 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 269796000724 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 269796000725 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 269796000726 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 269796000727 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 269796000728 RAMP superfamily; Region: RAMPs; cl19153 269796000729 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 269796000730 DNA-binding site [nucleotide binding]; DNA binding site 269796000731 RNA-binding motif; other site 269796000732 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 269796000733 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cl18985 269796000734 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 269796000735 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 269796000736 Transposase, Mutator family; Region: Transposase_mut; cl19537 269796000737 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269796000738 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269796000739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796000740 Walker A/P-loop; other site 269796000741 ATP binding site [chemical binding]; other site 269796000742 Q-loop/lid; other site 269796000743 ABC transporter signature motif; other site 269796000744 Walker B; other site 269796000745 D-loop; other site 269796000746 H-loop/switch region; other site 269796000747 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269796000748 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269796000749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796000750 Walker A/P-loop; other site 269796000751 ATP binding site [chemical binding]; other site 269796000752 Q-loop/lid; other site 269796000753 ABC transporter signature motif; other site 269796000754 Walker B; other site 269796000755 D-loop; other site 269796000756 H-loop/switch region; other site 269796000757 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 269796000758 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269796000759 N-terminal plug; other site 269796000760 ligand-binding site [chemical binding]; other site 269796000761 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cl00540 269796000762 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 269796000763 putative efflux protein, MATE family; Region: matE; TIGR00797 269796000764 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 269796000765 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 269796000766 dimer interface [polypeptide binding]; other site 269796000767 active site 269796000768 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 269796000769 Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795 269796000770 Restriction endonuclease; Region: Mrr_cat; pfam04471 269796000771 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 269796000772 putative catalytic site [active] 269796000773 putative metal binding site [ion binding]; other site 269796000774 putative phosphate binding site [ion binding]; other site 269796000775 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 269796000776 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 269796000777 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 269796000778 putative active site [active] 269796000779 putative active site [active] 269796000780 catalytic site [active] 269796000781 catalytic site [active] 269796000782 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 269796000783 putative active site [active] 269796000784 catalytic site [active] 269796000785 Uncharacterized conserved protein [Function unknown]; Region: COG0398 269796000786 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269796000787 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 269796000788 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 269796000789 HSP70 interaction site [polypeptide binding]; other site 269796000790 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 269796000791 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 269796000792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 269796000793 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 269796000794 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 269796000795 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 269796000796 metal ion-dependent adhesion site (MIDAS); other site 269796000797 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 269796000798 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269796000799 ATP binding site [chemical binding]; other site 269796000800 putative Mg++ binding site [ion binding]; other site 269796000801 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269796000802 nucleotide binding region [chemical binding]; other site 269796000803 ATP-binding site [chemical binding]; other site 269796000804 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 269796000805 putative active site [active] 269796000806 metal binding site [ion binding]; metal-binding site 269796000807 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 269796000808 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 269796000809 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 269796000810 nudix motif; other site 269796000811 EamA-like transporter family; Region: EamA; pfam00892 269796000812 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 269796000813 EamA-like transporter family; Region: EamA; pfam00892 269796000814 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 269796000815 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 269796000816 putative DNA binding site [nucleotide binding]; other site 269796000817 putative Zn2+ binding site [ion binding]; other site 269796000818 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 269796000819 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 269796000820 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 269796000821 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 269796000822 substrate binding site [chemical binding]; other site 269796000823 hinge regions; other site 269796000824 ADP binding site [chemical binding]; other site 269796000825 catalytic site [active] 269796000826 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 269796000827 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 269796000828 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 269796000829 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 269796000830 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 269796000831 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 269796000832 Radical SAM superfamily; Region: Radical_SAM; pfam04055 269796000833 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796000834 FeS/SAM binding site; other site 269796000835 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 269796000836 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 269796000837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796000838 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796000839 putative substrate translocation pore; other site 269796000840 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 269796000841 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 269796000842 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 269796000843 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796000844 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796000845 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 269796000846 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 269796000847 active site 269796000848 dimer interface [polypeptide binding]; other site 269796000849 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 269796000850 Ligand Binding Site [chemical binding]; other site 269796000851 Molecular Tunnel; other site 269796000852 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 269796000853 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 269796000854 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269796000855 ATP binding site [chemical binding]; other site 269796000856 putative Mg++ binding site [ion binding]; other site 269796000857 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 269796000858 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 269796000859 SEC-C motif; Region: SEC-C; pfam02810 269796000860 camphor resistance protein CrcB; Provisional; Region: PRK14206 269796000861 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 269796000862 Nudix N-terminal; Region: Nudix_N_2; pfam14803 269796000863 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 269796000864 nudix motif; other site 269796000865 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 269796000866 DNA methylase; Region: N6_N4_Mtase; pfam01555 269796000867 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 269796000868 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 269796000869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796000870 S-adenosylmethionine binding site [chemical binding]; other site 269796000871 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 269796000872 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 269796000873 active site 269796000874 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 269796000875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796000876 S-adenosylmethionine binding site [chemical binding]; other site 269796000877 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 269796000878 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 269796000879 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 269796000880 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 269796000881 putative ligand binding site [chemical binding]; other site 269796000882 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 269796000883 TM-ABC transporter signature motif; other site 269796000884 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 269796000885 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 269796000886 Walker A/P-loop; other site 269796000887 ATP binding site [chemical binding]; other site 269796000888 Q-loop/lid; other site 269796000889 ABC transporter signature motif; other site 269796000890 Walker B; other site 269796000891 D-loop; other site 269796000892 H-loop/switch region; other site 269796000893 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 269796000894 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 269796000895 N- and C-terminal domain interface [polypeptide binding]; other site 269796000896 D-xylulose kinase; Region: XylB; TIGR01312 269796000897 active site 269796000898 MgATP binding site [chemical binding]; other site 269796000899 catalytic site [active] 269796000900 metal binding site [ion binding]; metal-binding site 269796000901 xylulose binding site [chemical binding]; other site 269796000902 putative homodimer interface [polypeptide binding]; other site 269796000903 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 269796000904 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 269796000905 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796000906 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 269796000907 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 269796000908 inhibitor binding site; inhibition site 269796000909 catalytic Zn binding site [ion binding]; other site 269796000910 structural Zn binding site [ion binding]; other site 269796000911 NADP binding site [chemical binding]; other site 269796000912 tetramer interface [polypeptide binding]; other site 269796000913 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 269796000914 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 269796000915 NADP-binding site; other site 269796000916 homotetramer interface [polypeptide binding]; other site 269796000917 substrate binding site [chemical binding]; other site 269796000918 homodimer interface [polypeptide binding]; other site 269796000919 active site 269796000920 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 269796000921 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 269796000922 NADP binding site [chemical binding]; other site 269796000923 active site 269796000924 putative substrate binding site [chemical binding]; other site 269796000925 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 269796000926 Peptidase family M48; Region: Peptidase_M48; cl12018 269796000927 carbon starvation protein A; Provisional; Region: PRK15015 269796000928 Carbon starvation protein CstA; Region: CstA; pfam02554 269796000929 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 269796000930 Protein of unknown function (DUF466); Region: DUF466; pfam04328 269796000931 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 269796000932 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 269796000933 heme-binding site [chemical binding]; other site 269796000934 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796000935 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796000936 dimer interface [polypeptide binding]; other site 269796000937 putative CheW interface [polypeptide binding]; other site 269796000938 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 269796000939 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 269796000940 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 269796000941 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 269796000942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796000943 binding surface 269796000944 TPR motif; other site 269796000945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796000946 binding surface 269796000947 TPR motif; other site 269796000948 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796000949 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 269796000950 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 269796000951 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 269796000952 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269796000953 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 269796000954 Fe-S cluster binding site [ion binding]; other site 269796000955 active site 269796000956 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 269796000957 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 269796000958 N-acetyl-D-glucosamine binding site [chemical binding]; other site 269796000959 catalytic residue [active] 269796000960 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 269796000961 MPT binding site; other site 269796000962 trimer interface [polypeptide binding]; other site 269796000963 OmpA family; Region: OmpA; pfam00691 269796000964 ligand binding site [chemical binding]; other site 269796000965 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 269796000966 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 269796000967 active site 269796000968 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 269796000969 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 269796000970 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 269796000971 NAD(P) binding site [chemical binding]; other site 269796000972 homotetramer interface [polypeptide binding]; other site 269796000973 homodimer interface [polypeptide binding]; other site 269796000974 active site 269796000975 putative acyltransferase; Provisional; Region: PRK05790 269796000976 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 269796000977 dimer interface [polypeptide binding]; other site 269796000978 active site 269796000979 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 269796000980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 269796000981 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 269796000982 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 269796000983 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269796000984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796000985 non-specific DNA binding site [nucleotide binding]; other site 269796000986 salt bridge; other site 269796000987 sequence-specific DNA binding site [nucleotide binding]; other site 269796000988 epoxyqueuosine reductase; Region: TIGR00276 269796000989 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 269796000990 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 269796000991 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 269796000992 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 269796000993 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 269796000994 Predicted membrane protein [Function unknown]; Region: COG1971 269796000995 Domain of unknown function DUF; Region: DUF204; pfam02659 269796000996 Domain of unknown function DUF; Region: DUF204; pfam02659 269796000997 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 269796000998 thiamine pyrophosphate protein; Validated; Region: PRK08199 269796000999 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 269796001000 PYR/PP interface [polypeptide binding]; other site 269796001001 dimer interface [polypeptide binding]; other site 269796001002 TPP binding site [chemical binding]; other site 269796001003 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 269796001004 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 269796001005 TPP-binding site [chemical binding]; other site 269796001006 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 269796001007 tetrameric interface [polypeptide binding]; other site 269796001008 NAD binding site [chemical binding]; other site 269796001009 catalytic residues [active] 269796001010 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 269796001011 conserved cys residue [active] 269796001012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796001013 TPR motif; other site 269796001014 binding surface 269796001015 Tetratricopeptide repeat; Region: TPR_12; pfam13424 269796001016 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 269796001017 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 269796001018 active site 269796001019 catalytic tetrad [active] 269796001020 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 269796001021 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 269796001022 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 269796001023 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 269796001024 putative NADH binding site [chemical binding]; other site 269796001025 putative active site [active] 269796001026 nudix motif; other site 269796001027 putative metal binding site [ion binding]; other site 269796001028 Membrane transport protein; Region: Mem_trans; cl09117 269796001029 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 269796001030 dimer interface [polypeptide binding]; other site 269796001031 DNA binding site [nucleotide binding] 269796001032 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 269796001033 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 269796001034 RNA binding site [nucleotide binding]; other site 269796001035 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 269796001036 RNA binding site [nucleotide binding]; other site 269796001037 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 269796001038 RNA binding site [nucleotide binding]; other site 269796001039 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 269796001040 RNA binding site [nucleotide binding]; other site 269796001041 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 269796001042 RNA binding site [nucleotide binding]; other site 269796001043 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 269796001044 RNA binding site [nucleotide binding]; other site 269796001045 cytidylate kinase; Provisional; Region: cmk; PRK00023 269796001046 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 269796001047 CMP-binding site; other site 269796001048 The sites determining sugar specificity; other site 269796001049 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 269796001050 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 269796001051 hinge; other site 269796001052 active site 269796001053 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 269796001054 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 269796001055 Predicted esterase [General function prediction only]; Region: COG0627 269796001056 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 269796001057 NAD(P) binding site [chemical binding]; other site 269796001058 catalytic residues [active] 269796001059 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 269796001060 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 269796001061 catalytic triad [active] 269796001062 aminotransferase; Provisional; Region: PRK13356 269796001063 homodimer interface [polypeptide binding]; other site 269796001064 substrate-cofactor binding pocket; other site 269796001065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796001066 catalytic residue [active] 269796001067 Uncharacterized conserved protein [Function unknown]; Region: COG2128 269796001068 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 269796001069 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796001070 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 269796001071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796001072 non-specific DNA binding site [nucleotide binding]; other site 269796001073 salt bridge; other site 269796001074 sequence-specific DNA binding site [nucleotide binding]; other site 269796001075 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 269796001076 dimerization interface [polypeptide binding]; other site 269796001077 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 269796001078 ATP binding site [chemical binding]; other site 269796001079 Hydrogenase formation hypA family; Region: HypD; pfam01924 269796001080 HupF/HypC family; Region: HupF_HypC; pfam01455 269796001081 Acylphosphatase; Region: Acylphosphatase; pfam00708 269796001082 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 269796001083 HypF finger; Region: zf-HYPF; pfam07503 269796001084 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 269796001085 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 269796001086 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269796001087 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269796001088 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 269796001089 4Fe-4S binding domain; Region: Fer4; pfam00037 269796001090 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 269796001091 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 269796001092 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 269796001093 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 269796001094 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 269796001095 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269796001096 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 269796001097 hydrogenase 4 subunit D; Validated; Region: PRK06525 269796001098 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 269796001099 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269796001100 hydrogenase 4 subunit B; Validated; Region: PRK06521 269796001101 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269796001102 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 269796001103 Dos2-interacting transcription regulator of RNA-Pol-II; Region: MMS19_N; pfam14500 269796001104 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 269796001105 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 269796001106 NADH dehydrogenase; Region: NADHdh; cl00469 269796001107 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 269796001108 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269796001109 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 269796001110 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 269796001111 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269796001112 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 269796001113 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 269796001114 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 269796001115 nickel binding site [ion binding]; other site 269796001116 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 269796001117 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 269796001118 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 269796001119 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 269796001120 [4Fe-4S] binding site [ion binding]; other site 269796001121 molybdopterin cofactor binding site; other site 269796001122 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 269796001123 molybdopterin cofactor binding site; other site 269796001124 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 269796001125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796001126 FeS/SAM binding site; other site 269796001127 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 269796001128 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269796001129 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 269796001130 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269796001131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796001132 Walker A motif; other site 269796001133 ATP binding site [chemical binding]; other site 269796001134 Walker B motif; other site 269796001135 arginine finger; other site 269796001136 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 269796001137 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 269796001138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796001139 dimer interface [polypeptide binding]; other site 269796001140 phosphorylation site [posttranslational modification] 269796001141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796001142 ATP binding site [chemical binding]; other site 269796001143 Mg2+ binding site [ion binding]; other site 269796001144 G-X-G motif; other site 269796001145 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 269796001146 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796001147 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796001148 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 269796001149 putative dimerization interface [polypeptide binding]; other site 269796001150 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796001151 EamA-like transporter family; Region: EamA; pfam00892 269796001152 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 269796001153 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 269796001154 C-terminal domain interface [polypeptide binding]; other site 269796001155 GSH binding site (G-site) [chemical binding]; other site 269796001156 dimer interface [polypeptide binding]; other site 269796001157 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 269796001158 N-terminal domain interface [polypeptide binding]; other site 269796001159 putative dimer interface [polypeptide binding]; other site 269796001160 active site 269796001161 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 269796001162 Ferritin-like domain; Region: Ferritin; pfam00210 269796001163 dimerization interface [polypeptide binding]; other site 269796001164 DPS ferroxidase diiron center [ion binding]; other site 269796001165 ion pore; other site 269796001166 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 269796001167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796001168 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 269796001169 dimerization interface [polypeptide binding]; other site 269796001170 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 269796001171 putative deacylase active site [active] 269796001172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796001173 Methyltransferase domain; Region: Methyltransf_31; pfam13847 269796001174 S-adenosylmethionine binding site [chemical binding]; other site 269796001175 Predicted transcriptional regulators [Transcription]; Region: COG1733 269796001176 SnoaL-like domain; Region: SnoaL_2; pfam12680 269796001177 short chain dehydrogenase; Provisional; Region: PRK06523 269796001178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269796001179 NAD(P) binding site [chemical binding]; other site 269796001180 active site 269796001181 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 269796001182 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 269796001183 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 269796001184 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 269796001185 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 269796001186 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 269796001187 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 269796001188 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 269796001189 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 269796001190 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 269796001191 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 269796001192 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 269796001193 Replication initiator protein A; Region: RPA; pfam10134 269796001194 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 269796001195 integrase; Provisional; Region: PRK09692 269796001196 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 269796001197 active site 269796001198 Int/Topo IB signature motif; other site 269796001199 GMP synthase; Reviewed; Region: guaA; PRK00074 269796001200 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 269796001201 AMP/PPi binding site [chemical binding]; other site 269796001202 candidate oxyanion hole; other site 269796001203 catalytic triad [active] 269796001204 potential glutamine specificity residues [chemical binding]; other site 269796001205 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 269796001206 ATP Binding subdomain [chemical binding]; other site 269796001207 Ligand Binding sites [chemical binding]; other site 269796001208 Dimerization subdomain; other site 269796001209 isocitrate dehydrogenase; Validated; Region: PRK08299 269796001210 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 269796001211 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 269796001212 heme binding pocket [chemical binding]; other site 269796001213 heme ligand [chemical binding]; other site 269796001214 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 269796001215 intersubunit interface [polypeptide binding]; other site 269796001216 active site 269796001217 Zn2+ binding site [ion binding]; other site 269796001218 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 269796001219 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 269796001220 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 269796001221 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 269796001222 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 269796001223 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 269796001224 Qi binding site; other site 269796001225 cytochrome b; Provisional; Region: CYTB; MTH00156 269796001226 intrachain domain interface; other site 269796001227 interchain domain interface [polypeptide binding]; other site 269796001228 heme bH binding site [chemical binding]; other site 269796001229 heme bL binding site [chemical binding]; other site 269796001230 Qo binding site; other site 269796001231 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 269796001232 interchain domain interface [polypeptide binding]; other site 269796001233 intrachain domain interface; other site 269796001234 Qi binding site; other site 269796001235 Qo binding site; other site 269796001236 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 269796001237 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 269796001238 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 269796001239 [2Fe-2S] cluster binding site [ion binding]; other site 269796001240 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 269796001241 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 269796001242 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 269796001243 active site 269796001244 NTP binding site [chemical binding]; other site 269796001245 metal binding triad [ion binding]; metal-binding site 269796001246 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 269796001247 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 269796001248 putative active site [active] 269796001249 putative CoA binding site [chemical binding]; other site 269796001250 nudix motif; other site 269796001251 metal binding site [ion binding]; metal-binding site 269796001252 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 269796001253 MoxR-like ATPases [General function prediction only]; Region: COG0714 269796001254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796001255 Walker A motif; other site 269796001256 ATP binding site [chemical binding]; other site 269796001257 Walker B motif; other site 269796001258 arginine finger; other site 269796001259 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 269796001260 Protein of unknown function DUF58; Region: DUF58; pfam01882 269796001261 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 269796001262 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 269796001263 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 269796001264 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 269796001265 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 269796001266 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 269796001267 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 269796001268 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 269796001269 putative dimer interface [polypeptide binding]; other site 269796001270 N-terminal domain interface [polypeptide binding]; other site 269796001271 putative substrate binding pocket (H-site) [chemical binding]; other site 269796001272 Pirin-related protein [General function prediction only]; Region: COG1741 269796001273 Pirin; Region: Pirin; pfam02678 269796001274 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 269796001275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796001276 active site 269796001277 phosphorylation site [posttranslational modification] 269796001278 intermolecular recognition site; other site 269796001279 dimerization interface [polypeptide binding]; other site 269796001280 LytTr DNA-binding domain; Region: LytTR; pfam04397 269796001281 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 269796001282 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 269796001283 Histidine kinase; Region: His_kinase; pfam06580 269796001284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796001285 ATP binding site [chemical binding]; other site 269796001286 Mg2+ binding site [ion binding]; other site 269796001287 G-X-G motif; other site 269796001288 flavodoxin FldA; Validated; Region: PRK09267 269796001289 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 269796001290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796001291 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796001292 putative substrate translocation pore; other site 269796001293 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 269796001294 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 269796001295 DNA binding residues [nucleotide binding] 269796001296 putative dimer interface [polypeptide binding]; other site 269796001297 putative metal binding residues [ion binding]; other site 269796001298 Variant SH3 domain; Region: SH3_2; pfam07653 269796001299 peptide ligand binding site [polypeptide binding]; other site 269796001300 Src Homology 3 domain superfamily; Region: SH3; cl17036 269796001301 peptide ligand binding site [polypeptide binding]; other site 269796001302 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 269796001303 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 269796001304 putative NAD(P) binding site [chemical binding]; other site 269796001305 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223 269796001306 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269796001307 putative DNA binding site [nucleotide binding]; other site 269796001308 dimerization interface [polypeptide binding]; other site 269796001309 putative Zn2+ binding site [ion binding]; other site 269796001310 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 269796001311 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 269796001312 EamA-like transporter family; Region: EamA; pfam00892 269796001313 EamA-like transporter family; Region: EamA; pfam00892 269796001314 Uncharacterized conserved protein [Function unknown]; Region: COG1359 269796001315 hypothetical protein; Provisional; Region: nrdC.11; PHA02603 269796001316 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 269796001317 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 269796001318 putative MPT binding site; other site 269796001319 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 269796001320 active site 269796001321 8-oxo-dGMP binding site [chemical binding]; other site 269796001322 nudix motif; other site 269796001323 metal binding site [ion binding]; metal-binding site 269796001324 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 269796001325 heterotetramer interface [polypeptide binding]; other site 269796001326 active site pocket [active] 269796001327 cleavage site 269796001328 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 269796001329 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 269796001330 diaminopimelate decarboxylase; Region: lysA; TIGR01048 269796001331 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 269796001332 active site 269796001333 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 269796001334 substrate binding site [chemical binding]; other site 269796001335 catalytic residues [active] 269796001336 dimer interface [polypeptide binding]; other site 269796001337 argininosuccinate lyase; Provisional; Region: PRK00855 269796001338 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 269796001339 active sites [active] 269796001340 tetramer interface [polypeptide binding]; other site 269796001341 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 269796001342 catalytic residues [active] 269796001343 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 269796001344 active site 269796001345 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 269796001346 RES domain; Region: RES; smart00953 269796001347 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 269796001348 classical (c) SDRs; Region: SDR_c; cd05233 269796001349 NAD(P) binding site [chemical binding]; other site 269796001350 active site 269796001351 amidophosphoribosyltransferase; Provisional; Region: PRK09123 269796001352 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 269796001353 active site 269796001354 tetramer interface [polypeptide binding]; other site 269796001355 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269796001356 active site 269796001357 Colicin V production protein; Region: Colicin_V; pfam02674 269796001358 DNA repair protein RadA; Provisional; Region: PRK11823 269796001359 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 269796001360 Walker A motif; other site 269796001361 ATP binding site [chemical binding]; other site 269796001362 Walker B motif; other site 269796001363 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 269796001364 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 269796001365 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 269796001366 Walker A/P-loop; other site 269796001367 ATP binding site [chemical binding]; other site 269796001368 Q-loop/lid; other site 269796001369 ABC transporter signature motif; other site 269796001370 Walker B; other site 269796001371 D-loop; other site 269796001372 H-loop/switch region; other site 269796001373 Permease; Region: Permease; pfam02405 269796001374 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 269796001375 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 269796001376 active site 269796001377 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 269796001378 dimer interface [polypeptide binding]; other site 269796001379 substrate binding site [chemical binding]; other site 269796001380 catalytic residues [active] 269796001381 replicative DNA helicase; Provisional; Region: PRK09165 269796001382 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 269796001383 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 269796001384 Walker A motif; other site 269796001385 ATP binding site [chemical binding]; other site 269796001386 Walker B motif; other site 269796001387 DNA binding loops [nucleotide binding] 269796001388 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 269796001389 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 269796001390 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 269796001391 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 269796001392 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 269796001393 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 269796001394 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 269796001395 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 269796001396 NAD(P) binding site [chemical binding]; other site 269796001397 homotetramer interface [polypeptide binding]; other site 269796001398 homodimer interface [polypeptide binding]; other site 269796001399 active site 269796001400 acyl carrier protein; Provisional; Region: acpP; PRK00982 269796001401 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 269796001402 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 269796001403 dimer interface [polypeptide binding]; other site 269796001404 active site 269796001405 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 269796001406 dimerization interface [polypeptide binding]; other site 269796001407 PRC-barrel domain; Region: PRC; pfam05239 269796001408 PRC-barrel domain; Region: PRC; pfam05239 269796001409 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 269796001410 Protein of unknown function (DUF3096); Region: DUF3096; pfam11295 269796001411 short chain dehydrogenase; Provisional; Region: PRK07024 269796001412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269796001413 NAD(P) binding site [chemical binding]; other site 269796001414 active site 269796001415 hypothetical protein; Provisional; Region: PRK11820 269796001416 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 269796001417 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 269796001418 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 269796001419 Guanylate kinase; Region: Guanylate_kin; pfam00625 269796001420 catalytic site [active] 269796001421 G-X2-G-X-G-K; other site 269796001422 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 269796001423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796001424 S-adenosylmethionine binding site [chemical binding]; other site 269796001425 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 269796001426 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 269796001427 SurA N-terminal domain; Region: SurA_N; pfam09312 269796001428 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 269796001429 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 269796001430 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 269796001431 OstA-like protein; Region: OstA; cl00844 269796001432 Organic solvent tolerance protein; Region: OstA_C; pfam04453 269796001433 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 269796001434 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 269796001435 active site 269796001436 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 269796001437 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 269796001438 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 269796001439 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269796001440 ligand binding site [chemical binding]; other site 269796001441 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 269796001442 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 269796001443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796001444 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 269796001445 putative active site [active] 269796001446 heme pocket [chemical binding]; other site 269796001447 PAS domain; Region: PAS; smart00091 269796001448 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796001449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796001450 ATP binding site [chemical binding]; other site 269796001451 Mg2+ binding site [ion binding]; other site 269796001452 G-X-G motif; other site 269796001453 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 269796001454 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 269796001455 substrate binding pocket [chemical binding]; other site 269796001456 membrane-bound complex binding site; other site 269796001457 hinge residues; other site 269796001458 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 269796001459 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 269796001460 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 269796001461 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796001462 dimer interface [polypeptide binding]; other site 269796001463 putative CheW interface [polypeptide binding]; other site 269796001464 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 269796001465 FAD binding domain; Region: FAD_binding_4; pfam01565 269796001466 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 269796001467 LabA_like proteins; Region: LabA_like; cd06167 269796001468 putative metal binding site [ion binding]; other site 269796001469 Uncharacterized conserved protein [Function unknown]; Region: COG1432 269796001470 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 269796001471 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 269796001472 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 269796001473 active site 269796001474 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 269796001475 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 269796001476 putative ligand binding pocket/active site [active] 269796001477 putative metal binding site [ion binding]; other site 269796001478 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 269796001479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796001480 FeS/SAM binding site; other site 269796001481 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 269796001482 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 269796001483 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 269796001484 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 269796001485 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 269796001486 multifunctional aminopeptidase A; Provisional; Region: PRK00913 269796001487 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 269796001488 interface (dimer of trimers) [polypeptide binding]; other site 269796001489 Substrate-binding/catalytic site; other site 269796001490 Zn-binding sites [ion binding]; other site 269796001491 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 269796001492 nudix motif; other site 269796001493 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 269796001494 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 269796001495 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 269796001496 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 269796001497 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 269796001498 transcriptional regulator; Provisional; Region: PRK10632 269796001499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796001500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 269796001501 dimerization interface [polypeptide binding]; other site 269796001502 aldehyde dehydrogenase family 2 member; Region: PLN02466 269796001503 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 269796001504 NAD(P) binding site [chemical binding]; other site 269796001505 catalytic residues [active] 269796001506 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 269796001507 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 269796001508 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 269796001509 catalytic residue [active] 269796001510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269796001511 motif II; other site 269796001512 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 269796001513 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 269796001514 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 269796001515 PYR/PP interface [polypeptide binding]; other site 269796001516 dimer interface [polypeptide binding]; other site 269796001517 TPP binding site [chemical binding]; other site 269796001518 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 269796001519 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 269796001520 TPP-binding site [chemical binding]; other site 269796001521 dimer interface [polypeptide binding]; other site 269796001522 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 269796001523 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 269796001524 putative valine binding site [chemical binding]; other site 269796001525 dimer interface [polypeptide binding]; other site 269796001526 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 269796001527 ketol-acid reductoisomerase; Provisional; Region: PRK05479 269796001528 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 269796001529 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 269796001530 rod shape-determining protein MreB; Provisional; Region: PRK13927 269796001531 MreB and similar proteins; Region: MreB_like; cd10225 269796001532 nucleotide binding site [chemical binding]; other site 269796001533 Mg binding site [ion binding]; other site 269796001534 putative protofilament interaction site [polypeptide binding]; other site 269796001535 RodZ interaction site [polypeptide binding]; other site 269796001536 rod shape-determining protein MreC; Provisional; Region: PRK13922 269796001537 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 269796001538 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 269796001539 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 269796001540 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 269796001541 Prostaglandin dehydrogenases; Region: PGDH; cd05288 269796001542 NAD(P) binding site [chemical binding]; other site 269796001543 substrate binding site [chemical binding]; other site 269796001544 dimer interface [polypeptide binding]; other site 269796001545 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 269796001546 FMN binding site [chemical binding]; other site 269796001547 active site 269796001548 substrate binding site [chemical binding]; other site 269796001549 catalytic residue [active] 269796001550 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 269796001551 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 269796001552 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796001553 FeS/SAM binding site; other site 269796001554 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 269796001555 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 269796001556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796001557 FeS/SAM binding site; other site 269796001558 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 269796001559 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 269796001560 active site 269796001561 nucleophile elbow; other site 269796001562 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 269796001563 Predicted integral membrane protein [Function unknown]; Region: COG0392 269796001564 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407 269796001565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796001566 Walker A motif; other site 269796001567 ATP binding site [chemical binding]; other site 269796001568 Walker B motif; other site 269796001569 arginine finger; other site 269796001570 magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406 269796001571 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 269796001572 metal ion-dependent adhesion site (MIDAS); other site 269796001573 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 269796001574 Putative lysophospholipase; Region: Hydrolase_4; cl19140 269796001575 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 269796001576 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269796001577 N-terminal plug; other site 269796001578 ligand-binding site [chemical binding]; other site 269796001579 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 269796001580 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 269796001581 intersubunit interface [polypeptide binding]; other site 269796001582 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 269796001583 ABC-ATPase subunit interface; other site 269796001584 dimer interface [polypeptide binding]; other site 269796001585 putative PBP binding regions; other site 269796001586 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 269796001587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796001588 Walker A/P-loop; other site 269796001589 ATP binding site [chemical binding]; other site 269796001590 Q-loop/lid; other site 269796001591 ABC transporter signature motif; other site 269796001592 Walker B; other site 269796001593 D-loop; other site 269796001594 H-loop/switch region; other site 269796001595 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 269796001596 phytoene desaturase; Region: crtI_fam; TIGR02734 269796001597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796001598 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 269796001599 active site lid residues [active] 269796001600 substrate binding pocket [chemical binding]; other site 269796001601 catalytic residues [active] 269796001602 substrate-Mg2+ binding site; other site 269796001603 aspartate-rich region 1; other site 269796001604 aspartate-rich region 2; other site 269796001605 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 269796001606 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 269796001607 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269796001608 ligand binding site [chemical binding]; other site 269796001609 flexible hinge region; other site 269796001610 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 269796001611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796001612 Walker A/P-loop; other site 269796001613 ATP binding site [chemical binding]; other site 269796001614 Q-loop/lid; other site 269796001615 ABC transporter signature motif; other site 269796001616 Walker B; other site 269796001617 D-loop; other site 269796001618 H-loop/switch region; other site 269796001619 TOBE domain; Region: TOBE_2; pfam08402 269796001620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796001621 dimer interface [polypeptide binding]; other site 269796001622 conserved gate region; other site 269796001623 putative PBP binding loops; other site 269796001624 ABC-ATPase subunit interface; other site 269796001625 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 269796001626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796001627 dimer interface [polypeptide binding]; other site 269796001628 conserved gate region; other site 269796001629 putative PBP binding loops; other site 269796001630 ABC-ATPase subunit interface; other site 269796001631 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 269796001632 AAA domain; Region: AAA_23; pfam13476 269796001633 Walker A/P-loop; other site 269796001634 ATP binding site [chemical binding]; other site 269796001635 SOS regulatory protein LexA; Region: lexA; TIGR00498 269796001636 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 269796001637 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 269796001638 active site 269796001639 nucleotide binding site [chemical binding]; other site 269796001640 HIGH motif; other site 269796001641 KMSKS motif; other site 269796001642 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 269796001643 Peptidase family M23; Region: Peptidase_M23; pfam01551 269796001644 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 269796001645 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 269796001646 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 269796001647 active site 269796001648 catalytic site [active] 269796001649 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 269796001650 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 269796001651 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 269796001652 catalytic site [active] 269796001653 active site 269796001654 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 269796001655 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 269796001656 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 269796001657 active site 269796001658 catalytic site [active] 269796001659 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 269796001660 homodimer interface [polypeptide binding]; other site 269796001661 substrate-cofactor binding pocket; other site 269796001662 catalytic residue [active] 269796001663 Domain of unknown function (DUF955); Region: DUF955; cl01076 269796001664 Protein of unknown function (DUF3223); Region: DUF3223; pfam11523 269796001665 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269796001666 ATP binding site [chemical binding]; other site 269796001667 putative Mg++ binding site [ion binding]; other site 269796001668 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269796001669 nucleotide binding region [chemical binding]; other site 269796001670 ATP-binding site [chemical binding]; other site 269796001671 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 269796001672 Protein of unknown function (DUF952); Region: DUF952; pfam06108 269796001673 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 269796001674 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 269796001675 quinone interaction residues [chemical binding]; other site 269796001676 active site 269796001677 catalytic residues [active] 269796001678 FMN binding site [chemical binding]; other site 269796001679 substrate binding site [chemical binding]; other site 269796001680 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 269796001681 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 269796001682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269796001683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269796001684 Coenzyme A binding pocket [chemical binding]; other site 269796001685 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 269796001686 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 269796001687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796001688 FeS/SAM binding site; other site 269796001689 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 269796001690 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 269796001691 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 269796001692 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 269796001693 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 269796001694 putative binding surface; other site 269796001695 active site 269796001696 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 269796001697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796001698 ATP binding site [chemical binding]; other site 269796001699 Mg2+ binding site [ion binding]; other site 269796001700 G-X-G motif; other site 269796001701 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 269796001702 CheW-like domain; Region: CheW; pfam01584 269796001703 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796001704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796001705 active site 269796001706 phosphorylation site [posttranslational modification] 269796001707 intermolecular recognition site; other site 269796001708 dimerization interface [polypeptide binding]; other site 269796001709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796001710 active site 269796001711 phosphorylation site [posttranslational modification] 269796001712 intermolecular recognition site; other site 269796001713 dimerization interface [polypeptide binding]; other site 269796001714 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 269796001715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796001716 active site 269796001717 phosphorylation site [posttranslational modification] 269796001718 intermolecular recognition site; other site 269796001719 dimerization interface [polypeptide binding]; other site 269796001720 CheB methylesterase; Region: CheB_methylest; pfam01339 269796001721 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 269796001722 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 269796001723 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 269796001724 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796001725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796001726 active site 269796001727 phosphorylation site [posttranslational modification] 269796001728 intermolecular recognition site; other site 269796001729 dimerization interface [polypeptide binding]; other site 269796001730 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269796001731 DNA binding site [nucleotide binding] 269796001732 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 269796001733 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 269796001734 Walker A motif/ATP binding site; other site 269796001735 Walker B motif; other site 269796001736 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 269796001737 HSP70 interaction site [polypeptide binding]; other site 269796001738 Bacterial SH3 domain homologues; Region: SH3b; smart00287 269796001739 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 269796001740 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 269796001741 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 269796001742 FAD binding pocket [chemical binding]; other site 269796001743 FAD binding motif [chemical binding]; other site 269796001744 phosphate binding motif [ion binding]; other site 269796001745 beta-alpha-beta structure motif; other site 269796001746 NAD binding pocket [chemical binding]; other site 269796001747 large tegument protein UL36; Provisional; Region: PHA03247 269796001748 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 269796001749 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 269796001750 P-loop; other site 269796001751 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 269796001752 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 269796001753 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 269796001754 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796001755 EamA-like transporter family; Region: EamA; pfam00892 269796001756 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 269796001757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796001758 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796001759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796001760 salt bridge; other site 269796001761 non-specific DNA binding site [nucleotide binding]; other site 269796001762 sequence-specific DNA binding site [nucleotide binding]; other site 269796001763 Domain of unknown function (DUF955); Region: DUF955; cl01076 269796001764 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 269796001765 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 269796001766 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269796001767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796001768 active site 269796001769 phosphorylation site [posttranslational modification] 269796001770 intermolecular recognition site; other site 269796001771 dimerization interface [polypeptide binding]; other site 269796001772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796001773 Walker A motif; other site 269796001774 ATP binding site [chemical binding]; other site 269796001775 Walker B motif; other site 269796001776 arginine finger; other site 269796001777 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269796001778 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 269796001779 flagellar motor switch protein; Reviewed; Region: PRK08916 269796001780 flagellar assembly protein H; Validated; Region: fliH; PRK06032 269796001781 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 269796001782 FliG N-terminal domain; Region: FliG_N; pfam14842 269796001783 FliG middle domain; Region: FliG_M; pfam14841 269796001784 FliG C-terminal domain; Region: FliG_C; pfam01706 269796001785 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 269796001786 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 269796001787 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 269796001788 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 269796001789 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 269796001790 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 269796001791 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 269796001792 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 269796001793 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 269796001794 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 269796001795 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 269796001796 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269796001797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796001798 TPR motif; other site 269796001799 binding surface 269796001800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796001801 binding surface 269796001802 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269796001803 TPR motif; other site 269796001804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796001805 TPR motif; other site 269796001806 binding surface 269796001807 TPR repeat; Region: TPR_11; pfam13414 269796001808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796001809 binding surface 269796001810 TPR motif; other site 269796001811 TPR repeat; Region: TPR_11; pfam13414 269796001812 Src Homology 3 domain superfamily; Region: SH3; cl17036 269796001813 peptide ligand binding site [polypeptide binding]; other site 269796001814 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 269796001815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269796001816 Coenzyme A binding pocket [chemical binding]; other site 269796001817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 269796001818 active site 269796001819 phosphorylation site [posttranslational modification] 269796001820 intermolecular recognition site; other site 269796001821 dimerization interface [polypeptide binding]; other site 269796001822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796001823 dimer interface [polypeptide binding]; other site 269796001824 phosphorylation site [posttranslational modification] 269796001825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796001826 ATP binding site [chemical binding]; other site 269796001827 Mg2+ binding site [ion binding]; other site 269796001828 G-X-G motif; other site 269796001829 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 269796001830 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 269796001831 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 269796001832 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 269796001833 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 269796001834 putative active site [active] 269796001835 putative substrate binding site [chemical binding]; other site 269796001836 putative cosubstrate binding site; other site 269796001837 catalytic site [active] 269796001838 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 269796001839 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 269796001840 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 269796001841 homodimer interface [polypeptide binding]; other site 269796001842 NADP binding site [chemical binding]; other site 269796001843 substrate binding site [chemical binding]; other site 269796001844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796001845 PAS domain; Region: PAS_9; pfam13426 269796001846 putative active site [active] 269796001847 heme pocket [chemical binding]; other site 269796001848 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796001849 metal binding site [ion binding]; metal-binding site 269796001850 active site 269796001851 I-site; other site 269796001852 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796001853 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 269796001854 Putative lysophospholipase; Region: Hydrolase_4; cl19140 269796001855 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 269796001856 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 269796001857 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 269796001858 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 269796001859 Trypsin; Region: Trypsin; pfam00089 269796001860 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 269796001861 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 269796001862 putative ligand binding site [chemical binding]; other site 269796001863 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 269796001864 putative outer membrane receptor; Provisional; Region: PRK13513 269796001865 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 269796001866 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 269796001867 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 269796001868 FAD binding pocket [chemical binding]; other site 269796001869 FAD binding motif [chemical binding]; other site 269796001870 phosphate binding motif [ion binding]; other site 269796001871 beta-alpha-beta structure motif; other site 269796001872 NAD binding pocket [chemical binding]; other site 269796001873 Iron coordination center [ion binding]; other site 269796001874 Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356 269796001875 CHASE3 domain; Region: CHASE3; cl05000 269796001876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796001877 dimerization interface [polypeptide binding]; other site 269796001878 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796001879 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796001880 dimer interface [polypeptide binding]; other site 269796001881 putative CheW interface [polypeptide binding]; other site 269796001882 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 269796001883 glutamate--cysteine ligase; Region: PLN02611 269796001884 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 269796001885 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 269796001886 putative active site [active] 269796001887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796001888 S-adenosylmethionine binding site [chemical binding]; other site 269796001889 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 269796001890 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 269796001891 Cache domain; Region: Cache_1; pfam02743 269796001892 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796001893 dimerization interface [polypeptide binding]; other site 269796001894 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796001895 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796001896 dimer interface [polypeptide binding]; other site 269796001897 putative CheW interface [polypeptide binding]; other site 269796001898 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 269796001899 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 269796001900 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 269796001901 putative active site [active] 269796001902 putative metal binding site [ion binding]; other site 269796001903 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796001904 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 269796001905 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 269796001906 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 269796001907 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 269796001908 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 269796001909 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796001910 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796001911 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 269796001912 TM-ABC transporter signature motif; other site 269796001913 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 269796001914 TM-ABC transporter signature motif; other site 269796001915 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 269796001916 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 269796001917 Walker A/P-loop; other site 269796001918 ATP binding site [chemical binding]; other site 269796001919 Q-loop/lid; other site 269796001920 ABC transporter signature motif; other site 269796001921 Walker B; other site 269796001922 D-loop; other site 269796001923 H-loop/switch region; other site 269796001924 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 269796001925 oligomerisation interface [polypeptide binding]; other site 269796001926 mobile loop; other site 269796001927 roof hairpin; other site 269796001928 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 269796001929 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 269796001930 ring oligomerisation interface [polypeptide binding]; other site 269796001931 ATP/Mg binding site [chemical binding]; other site 269796001932 stacking interactions; other site 269796001933 hinge regions; other site 269796001934 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 269796001935 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796001936 Walker A/P-loop; other site 269796001937 ATP binding site [chemical binding]; other site 269796001938 Q-loop/lid; other site 269796001939 ABC transporter signature motif; other site 269796001940 Walker B; other site 269796001941 D-loop; other site 269796001942 H-loop/switch region; other site 269796001943 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 269796001944 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 269796001945 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796001946 Walker A/P-loop; other site 269796001947 ATP binding site [chemical binding]; other site 269796001948 Q-loop/lid; other site 269796001949 ABC transporter signature motif; other site 269796001950 Walker B; other site 269796001951 D-loop; other site 269796001952 H-loop/switch region; other site 269796001953 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 269796001954 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 269796001955 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 269796001956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796001957 dimer interface [polypeptide binding]; other site 269796001958 conserved gate region; other site 269796001959 putative PBP binding loops; other site 269796001960 ABC-ATPase subunit interface; other site 269796001961 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 269796001962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796001963 dimer interface [polypeptide binding]; other site 269796001964 conserved gate region; other site 269796001965 putative PBP binding loops; other site 269796001966 ABC-ATPase subunit interface; other site 269796001967 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 269796001968 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 269796001969 peptide binding site [polypeptide binding]; other site 269796001970 TMAO/DMSO reductase; Reviewed; Region: PRK05363 269796001971 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 269796001972 Moco binding site; other site 269796001973 metal coordination site [ion binding]; other site 269796001974 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 269796001975 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 269796001976 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 269796001977 TPP-binding site [chemical binding]; other site 269796001978 dimer interface [polypeptide binding]; other site 269796001979 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 269796001980 PYR/PP interface [polypeptide binding]; other site 269796001981 dimer interface [polypeptide binding]; other site 269796001982 TPP binding site [chemical binding]; other site 269796001983 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 269796001984 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 269796001985 intersubunit interface [polypeptide binding]; other site 269796001986 active site 269796001987 zinc binding site [ion binding]; other site 269796001988 Na+ binding site [ion binding]; other site 269796001989 Abi-like protein; Region: Abi_2; pfam07751 269796001990 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 269796001991 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 269796001992 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 269796001993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796001994 dimer interface [polypeptide binding]; other site 269796001995 conserved gate region; other site 269796001996 putative PBP binding loops; other site 269796001997 ABC-ATPase subunit interface; other site 269796001998 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 269796001999 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 269796002000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796002001 dimer interface [polypeptide binding]; other site 269796002002 conserved gate region; other site 269796002003 putative PBP binding loops; other site 269796002004 ABC-ATPase subunit interface; other site 269796002005 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 269796002006 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 269796002007 Walker A/P-loop; other site 269796002008 ATP binding site [chemical binding]; other site 269796002009 Q-loop/lid; other site 269796002010 ABC transporter signature motif; other site 269796002011 Walker B; other site 269796002012 D-loop; other site 269796002013 H-loop/switch region; other site 269796002014 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 269796002015 PhoU domain; Region: PhoU; pfam01895 269796002016 PhoU domain; Region: PhoU; pfam01895 269796002017 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 269796002018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796002019 active site 269796002020 phosphorylation site [posttranslational modification] 269796002021 intermolecular recognition site; other site 269796002022 dimerization interface [polypeptide binding]; other site 269796002023 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269796002024 DNA binding site [nucleotide binding] 269796002025 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 269796002026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796002027 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 269796002028 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 269796002029 putative dimerization interface [polypeptide binding]; other site 269796002030 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269796002031 active site 269796002032 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 269796002033 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 269796002034 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 269796002035 Ligand Binding Site [chemical binding]; other site 269796002036 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 269796002037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796002038 PAS domain; Region: PAS_9; pfam13426 269796002039 putative active site [active] 269796002040 heme pocket [chemical binding]; other site 269796002041 RNase II stability modulator; Provisional; Region: PRK10060 269796002042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796002043 putative active site [active] 269796002044 heme pocket [chemical binding]; other site 269796002045 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796002046 metal binding site [ion binding]; metal-binding site 269796002047 active site 269796002048 I-site; other site 269796002049 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796002050 V4R domain; Region: V4R; cl15268 269796002051 putative photosynthetic complex assembly protein 2; Region: photo_alph_chp2; TIGR03055 269796002052 putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054 269796002053 Bacterial PH domain; Region: bPH_2; pfam03703 269796002054 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cd00226 269796002055 photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150 269796002056 subunit C interaction residues; other site 269796002057 subunit M interaction residues [polypeptide binding]; other site 269796002058 subunit L interaction residues [polypeptide binding]; other site 269796002059 putative proton transfer pathway, P1; other site 269796002060 putative proton transfer pathway, P2; other site 269796002061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796002062 putative substrate translocation pore; other site 269796002063 PUCC protein; Region: PUCC; pfam03209 269796002064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796002065 S-adenosylmethionine binding site [chemical binding]; other site 269796002066 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 269796002067 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 269796002068 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796002069 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 269796002070 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 269796002071 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 269796002072 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 269796002073 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 269796002074 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 269796002075 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 269796002076 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 269796002077 PAS domain; Region: PAS_8; pfam13188 269796002078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796002079 putative active site [active] 269796002080 heme pocket [chemical binding]; other site 269796002081 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269796002082 Bacteriochlorophyll/chlorophyll synthetase; Region: PT_UbiA_chlorophyll; cd13958 269796002083 putative active site [active] 269796002084 PUCC protein; Region: PUCC; pfam03209 269796002085 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 269796002086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796002087 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796002088 PAS fold; Region: PAS_3; pfam08447 269796002089 putative active site [active] 269796002090 heme pocket [chemical binding]; other site 269796002091 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796002092 metal binding site [ion binding]; metal-binding site 269796002093 active site 269796002094 I-site; other site 269796002095 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269796002096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796002097 dimerization interface [polypeptide binding]; other site 269796002098 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796002099 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269796002100 dimer interface [polypeptide binding]; other site 269796002101 putative CheW interface [polypeptide binding]; other site 269796002102 Hemerythrin; Region: Hemerythrin; cd12107 269796002103 Fe binding site [ion binding]; other site 269796002104 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 269796002105 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 269796002106 active site 269796002107 catalytic site [active] 269796002108 substrate binding site [chemical binding]; other site 269796002109 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 269796002110 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269796002111 ligand binding site [chemical binding]; other site 269796002112 flexible hinge region; other site 269796002113 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 269796002114 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 269796002115 metal binding triad; other site 269796002116 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 269796002117 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 269796002118 Na binding site [ion binding]; other site 269796002119 Protein of unknown function, DUF485; Region: DUF485; pfam04341 269796002120 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 269796002121 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 269796002122 catalytic residue [active] 269796002123 RecX family; Region: RecX; pfam02631 269796002124 ABC-2 type transporter; Region: ABC2_membrane; cl17235 269796002125 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 269796002126 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 269796002127 Uncharacterized conserved protein [Function unknown]; Region: COG1565 269796002128 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 269796002129 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 269796002130 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 269796002131 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 269796002132 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269796002133 active site 269796002134 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 269796002135 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 269796002136 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 269796002137 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 269796002138 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 269796002139 tetramer interface [polypeptide binding]; other site 269796002140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796002141 catalytic residue [active] 269796002142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796002143 S-adenosylmethionine binding site [chemical binding]; other site 269796002144 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 269796002145 nucleoside/Zn binding site; other site 269796002146 dimer interface [polypeptide binding]; other site 269796002147 catalytic motif [active] 269796002148 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 269796002149 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 269796002150 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 269796002151 catalytic triad [active] 269796002152 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 269796002153 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269796002154 RNA binding surface [nucleotide binding]; other site 269796002155 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 269796002156 active site 269796002157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796002158 S-adenosylmethionine binding site [chemical binding]; other site 269796002159 inner membrane protein; Provisional; Region: PRK10995 269796002160 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 269796002161 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269796002162 putative DNA binding site [nucleotide binding]; other site 269796002163 putative Zn2+ binding site [ion binding]; other site 269796002164 AsnC family; Region: AsnC_trans_reg; pfam01037 269796002165 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 269796002166 DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850 269796002167 Proline dehydrogenase; Region: Pro_dh; pfam01619 269796002168 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 269796002169 Glutamate binding site [chemical binding]; other site 269796002170 NAD binding site [chemical binding]; other site 269796002171 catalytic residues [active] 269796002172 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 269796002173 Lysine efflux permease [General function prediction only]; Region: COG1279 269796002174 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 269796002175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796002176 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 269796002177 dimerization interface [polypeptide binding]; other site 269796002178 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 269796002179 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796002180 metal binding site [ion binding]; metal-binding site 269796002181 active site 269796002182 I-site; other site 269796002183 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796002184 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 269796002185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796002186 ATP binding site [chemical binding]; other site 269796002187 Mg2+ binding site [ion binding]; other site 269796002188 G-X-G motif; other site 269796002189 Haemolysin-III related; Region: HlyIII; cl03831 269796002190 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 269796002191 rRNA binding site [nucleotide binding]; other site 269796002192 predicted 30S ribosome binding site; other site 269796002193 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 269796002194 DNA-binding site [nucleotide binding]; DNA binding site 269796002195 RNA-binding motif; other site 269796002196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796002197 active site 269796002198 phosphorylation site [posttranslational modification] 269796002199 intermolecular recognition site; other site 269796002200 dimerization interface [polypeptide binding]; other site 269796002201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 269796002202 Histidine kinase; Region: HisKA_2; pfam07568 269796002203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796002204 ATP binding site [chemical binding]; other site 269796002205 Mg2+ binding site [ion binding]; other site 269796002206 G-X-G motif; other site 269796002207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796002208 active site 269796002209 phosphorylation site [posttranslational modification] 269796002210 intermolecular recognition site; other site 269796002211 dimerization interface [polypeptide binding]; other site 269796002212 CHASE3 domain; Region: CHASE3; pfam05227 269796002213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796002214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796002215 dimer interface [polypeptide binding]; other site 269796002216 phosphorylation site [posttranslational modification] 269796002217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796002218 ATP binding site [chemical binding]; other site 269796002219 Mg2+ binding site [ion binding]; other site 269796002220 G-X-G motif; other site 269796002221 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 269796002222 putative dimer interface [polypeptide binding]; other site 269796002223 active site pocket [active] 269796002224 putative cataytic base [active] 269796002225 cobalamin synthase; Reviewed; Region: cobS; PRK00235 269796002226 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 269796002227 catalytic core [active] 269796002228 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 269796002229 homotrimer interface [polypeptide binding]; other site 269796002230 Walker A motif; other site 269796002231 GTP binding site [chemical binding]; other site 269796002232 Walker B motif; other site 269796002233 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 269796002234 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 269796002235 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 269796002236 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 269796002237 active site 269796002238 DNA binding site [nucleotide binding] 269796002239 Int/Topo IB signature motif; other site 269796002240 Restriction endonuclease; Region: Mrr_cat; cl19295 269796002241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269796002242 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269796002243 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269796002244 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 269796002245 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 269796002246 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 269796002247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796002248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796002249 glutathione reductase; Validated; Region: PRK06116 269796002250 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796002251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269796002252 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 269796002253 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 269796002254 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 269796002255 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 269796002256 active site 269796002257 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796002258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796002259 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 269796002260 putative dimerization interface [polypeptide binding]; other site 269796002261 NAD synthetase; Provisional; Region: PRK13981 269796002262 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 269796002263 multimer interface [polypeptide binding]; other site 269796002264 active site 269796002265 catalytic triad [active] 269796002266 protein interface 1 [polypeptide binding]; other site 269796002267 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 269796002268 homodimer interface [polypeptide binding]; other site 269796002269 NAD binding pocket [chemical binding]; other site 269796002270 ATP binding pocket [chemical binding]; other site 269796002271 Mg binding site [ion binding]; other site 269796002272 active-site loop [active] 269796002273 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 269796002274 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 269796002275 active site 269796002276 nucleotide binding site [chemical binding]; other site 269796002277 HIGH motif; other site 269796002278 KMSKS motif; other site 269796002279 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 269796002280 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 269796002281 active site 269796002282 HIGH motif; other site 269796002283 KMSKS motif; other site 269796002284 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 269796002285 tRNA binding surface [nucleotide binding]; other site 269796002286 anticodon binding site; other site 269796002287 Uncharacterized conserved protein [Function unknown]; Region: COG3287 269796002288 FIST N domain; Region: FIST; smart00897 269796002289 FIST C domain; Region: FIST_C; pfam10442 269796002290 PAS fold; Region: PAS_7; pfam12860 269796002291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796002292 PAS domain; Region: PAS_9; pfam13426 269796002293 putative active site [active] 269796002294 heme pocket [chemical binding]; other site 269796002295 PAS domain; Region: PAS_8; pfam13188 269796002296 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 269796002297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796002298 ATP binding site [chemical binding]; other site 269796002299 Mg2+ binding site [ion binding]; other site 269796002300 G-X-G motif; other site 269796002301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796002302 active site 269796002303 phosphorylation site [posttranslational modification] 269796002304 intermolecular recognition site; other site 269796002305 dimerization interface [polypeptide binding]; other site 269796002306 HDOD domain; Region: HDOD; pfam08668 269796002307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796002308 active site 269796002309 phosphorylation site [posttranslational modification] 269796002310 intermolecular recognition site; other site 269796002311 dimerization interface [polypeptide binding]; other site 269796002312 HD domain; Region: HD_5; pfam13487 269796002313 GAF domain; Region: GAF; pfam01590 269796002314 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 269796002315 Histidine kinase; Region: HisKA_2; pfam07568 269796002316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796002317 ATP binding site [chemical binding]; other site 269796002318 Mg2+ binding site [ion binding]; other site 269796002319 G-X-G motif; other site 269796002320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796002321 active site 269796002322 phosphorylation site [posttranslational modification] 269796002323 intermolecular recognition site; other site 269796002324 dimerization interface [polypeptide binding]; other site 269796002325 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 269796002326 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 269796002327 active site 269796002328 catalytic residues [active] 269796002329 metal binding site [ion binding]; metal-binding site 269796002330 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 269796002331 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 269796002332 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 269796002333 multidrug efflux protein; Reviewed; Region: PRK01766 269796002334 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 269796002335 cation binding site [ion binding]; other site 269796002336 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 269796002337 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 269796002338 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 269796002339 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 269796002340 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 269796002341 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 269796002342 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269796002343 RNA binding surface [nucleotide binding]; other site 269796002344 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 269796002345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796002346 Walker A/P-loop; other site 269796002347 ATP binding site [chemical binding]; other site 269796002348 Q-loop/lid; other site 269796002349 ABC transporter signature motif; other site 269796002350 Walker B; other site 269796002351 D-loop; other site 269796002352 H-loop/switch region; other site 269796002353 TOBE domain; Region: TOBE; cl01440 269796002354 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 269796002355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796002356 dimer interface [polypeptide binding]; other site 269796002357 conserved gate region; other site 269796002358 putative PBP binding loops; other site 269796002359 ABC-ATPase subunit interface; other site 269796002360 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 269796002361 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 269796002362 putative GSH binding site [chemical binding]; other site 269796002363 catalytic residues [active] 269796002364 Predicted permeases [General function prediction only]; Region: RarD; COG2962 269796002365 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 269796002366 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 269796002367 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 269796002368 dimerization interface [polypeptide binding]; other site 269796002369 ATP binding site [chemical binding]; other site 269796002370 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 269796002371 dimerization interface [polypeptide binding]; other site 269796002372 ATP binding site [chemical binding]; other site 269796002373 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 269796002374 putative active site [active] 269796002375 catalytic triad [active] 269796002376 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 269796002377 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 269796002378 ATP binding site [chemical binding]; other site 269796002379 active site 269796002380 substrate binding site [chemical binding]; other site 269796002381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796002382 non-specific DNA binding site [nucleotide binding]; other site 269796002383 salt bridge; other site 269796002384 sequence-specific DNA binding site [nucleotide binding]; other site 269796002385 NRDE protein; Region: NRDE; cl01315 269796002386 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 269796002387 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 269796002388 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 269796002389 Cl binding site [ion binding]; other site 269796002390 oligomer interface [polypeptide binding]; other site 269796002391 adenylosuccinate lyase; Provisional; Region: PRK07492 269796002392 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 269796002393 tetramer interface [polypeptide binding]; other site 269796002394 active site 269796002395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796002396 non-specific DNA binding site [nucleotide binding]; other site 269796002397 salt bridge; other site 269796002398 sequence-specific DNA binding site [nucleotide binding]; other site 269796002399 Predicted transcriptional regulator [Transcription]; Region: COG2932 269796002400 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 269796002401 Catalytic site [active] 269796002402 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 269796002403 HAMP domain; Region: HAMP; pfam00672 269796002404 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796002405 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796002406 dimer interface [polypeptide binding]; other site 269796002407 putative CheW interface [polypeptide binding]; other site 269796002408 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 269796002409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 269796002410 substrate binding pocket [chemical binding]; other site 269796002411 membrane-bound complex binding site; other site 269796002412 Transcriptional regulators [Transcription]; Region: MarR; COG1846 269796002413 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 269796002414 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 269796002415 Putative zinc-finger; Region: zf-HC2; pfam13490 269796002416 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 269796002417 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 269796002418 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269796002419 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269796002420 DNA binding residues [nucleotide binding] 269796002421 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 269796002422 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 269796002423 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 269796002424 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 269796002425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796002426 S-adenosylmethionine binding site [chemical binding]; other site 269796002427 MFS/sugar transport protein; Region: MFS_2; pfam13347 269796002428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796002429 putative substrate translocation pore; other site 269796002430 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 269796002431 SnoaL-like domain; Region: SnoaL_2; pfam12680 269796002432 short chain dehydrogenase; Provisional; Region: PRK07024 269796002433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269796002434 NAD(P) binding site [chemical binding]; other site 269796002435 active site 269796002436 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 269796002437 hypothetical protein; Reviewed; Region: PRK00024 269796002438 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 269796002439 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 269796002440 MPN+ (JAMM) motif; other site 269796002441 Zinc-binding site [ion binding]; other site 269796002442 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 269796002443 active site 269796002444 Predicted thioesterase [General function prediction only]; Region: COG5496 269796002445 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 269796002446 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 269796002447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796002448 S-adenosylmethionine binding site [chemical binding]; other site 269796002449 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 269796002450 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269796002451 active site 269796002452 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 269796002453 GSH binding site [chemical binding]; other site 269796002454 catalytic residues [active] 269796002455 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 269796002456 putative active site [active] 269796002457 catalytic triad [active] 269796002458 dimer interface [polypeptide binding]; other site 269796002459 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 269796002460 PAS fold; Region: PAS_4; pfam08448 269796002461 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 269796002462 HWE histidine kinase; Region: HWE_HK; smart00911 269796002463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 269796002464 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 269796002465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796002466 S-adenosylmethionine binding site [chemical binding]; other site 269796002467 aspartate kinase; Reviewed; Region: PRK06635 269796002468 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 269796002469 putative nucleotide binding site [chemical binding]; other site 269796002470 putative catalytic residues [active] 269796002471 putative Mg ion binding site [ion binding]; other site 269796002472 putative aspartate binding site [chemical binding]; other site 269796002473 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 269796002474 putative allosteric regulatory site; other site 269796002475 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 269796002476 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 269796002477 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 269796002478 FMN binding site [chemical binding]; other site 269796002479 substrate binding site [chemical binding]; other site 269796002480 putative catalytic residue [active] 269796002481 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 269796002482 GAF domain; Region: GAF; pfam01590 269796002483 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 269796002484 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 269796002485 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 269796002486 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 269796002487 Helix-turn-helix domain; Region: HTH_25; pfam13413 269796002488 Protein of unknown function (DUF1032); Region: DUF1032; pfam06278 269796002489 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 269796002490 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 269796002491 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 269796002492 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 269796002493 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 269796002494 dimer interface [polypeptide binding]; other site 269796002495 motif 1; other site 269796002496 active site 269796002497 motif 2; other site 269796002498 motif 3; other site 269796002499 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 269796002500 anticodon binding site; other site 269796002501 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 269796002502 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 269796002503 NAD(P) binding pocket [chemical binding]; other site 269796002504 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 269796002505 peptide chain release factor 1; Validated; Region: prfA; PRK00591 269796002506 This domain is found in peptide chain release factors; Region: PCRF; smart00937 269796002507 RF-1 domain; Region: RF-1; pfam00472 269796002508 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 269796002509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796002510 S-adenosylmethionine binding site [chemical binding]; other site 269796002511 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 269796002512 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 269796002513 Clp amino terminal domain; Region: Clp_N; pfam02861 269796002514 Clp amino terminal domain; Region: Clp_N; pfam02861 269796002515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796002516 Walker A motif; other site 269796002517 ATP binding site [chemical binding]; other site 269796002518 Walker B motif; other site 269796002519 arginine finger; other site 269796002520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796002521 Walker A motif; other site 269796002522 ATP binding site [chemical binding]; other site 269796002523 Walker B motif; other site 269796002524 arginine finger; other site 269796002525 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 269796002526 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 269796002527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796002528 dimerization interface [polypeptide binding]; other site 269796002529 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796002530 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796002531 dimer interface [polypeptide binding]; other site 269796002532 putative CheW interface [polypeptide binding]; other site 269796002533 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 269796002534 Domain of unknown function DUF21; Region: DUF21; pfam01595 269796002535 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 269796002536 Transporter associated domain; Region: CorC_HlyC; smart01091 269796002537 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 269796002538 catalytic triad [active] 269796002539 conserved cis-peptide bond; other site 269796002540 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 269796002541 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 269796002542 conserved cys residue [active] 269796002543 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796002544 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 269796002545 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 269796002546 active site 269796002547 catalytic tetrad [active] 269796002548 large tegument protein UL36; Provisional; Region: PHA03247 269796002549 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 269796002550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796002551 FeS/SAM binding site; other site 269796002552 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 269796002553 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 269796002554 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796002555 Radical SAM superfamily; Region: Radical_SAM; pfam04055 269796002556 FeS/SAM binding site; other site 269796002557 SynChlorMet cassette radical SAM/SPASM protein ScmE; Region: SCM_rSAM_ScmE; TIGR04250 269796002558 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796002559 FeS/SAM binding site; other site 269796002560 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 269796002561 AAA ATPase domain; Region: AAA_16; pfam13191 269796002562 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 269796002563 active site 269796002564 purine riboside binding site [chemical binding]; other site 269796002565 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 269796002566 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 269796002567 Walker A/P-loop; other site 269796002568 ATP binding site [chemical binding]; other site 269796002569 Q-loop/lid; other site 269796002570 ABC transporter signature motif; other site 269796002571 Walker B; other site 269796002572 D-loop; other site 269796002573 H-loop/switch region; other site 269796002574 TOBE domain; Region: TOBE_2; pfam08402 269796002575 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 269796002576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796002577 dimer interface [polypeptide binding]; other site 269796002578 conserved gate region; other site 269796002579 putative PBP binding loops; other site 269796002580 ABC-ATPase subunit interface; other site 269796002581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796002582 dimer interface [polypeptide binding]; other site 269796002583 conserved gate region; other site 269796002584 putative PBP binding loops; other site 269796002585 ABC-ATPase subunit interface; other site 269796002586 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 269796002587 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 269796002588 Peptidase family M23; Region: Peptidase_M23; pfam01551 269796002589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 269796002590 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 269796002591 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 269796002592 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 269796002593 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 269796002594 homodimer interface [polypeptide binding]; other site 269796002595 substrate-cofactor binding pocket; other site 269796002596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796002597 catalytic residue [active] 269796002598 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 269796002599 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 269796002600 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 269796002601 hypothetical protein; Provisional; Region: PRK08912 269796002602 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269796002603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796002604 homodimer interface [polypeptide binding]; other site 269796002605 catalytic residue [active] 269796002606 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 269796002607 FAD binding domain; Region: FAD_binding_4; pfam01565 269796002608 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 269796002609 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 269796002610 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 269796002611 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 269796002612 substrate binding pocket [chemical binding]; other site 269796002613 membrane-bound complex binding site; other site 269796002614 hinge residues; other site 269796002615 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 269796002616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 269796002617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796002618 putative PBP binding loops; other site 269796002619 dimer interface [polypeptide binding]; other site 269796002620 ABC-ATPase subunit interface; other site 269796002621 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 269796002622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796002623 dimer interface [polypeptide binding]; other site 269796002624 conserved gate region; other site 269796002625 putative PBP binding loops; other site 269796002626 ABC-ATPase subunit interface; other site 269796002627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796002628 non-specific DNA binding site [nucleotide binding]; other site 269796002629 salt bridge; other site 269796002630 sequence-specific DNA binding site [nucleotide binding]; other site 269796002631 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 269796002632 RES domain; Region: RES; smart00953 269796002633 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 269796002634 homodimer interface [polypeptide binding]; other site 269796002635 substrate-cofactor binding pocket; other site 269796002636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796002637 catalytic residue [active] 269796002638 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 269796002639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796002640 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 269796002641 dimerization interface [polypeptide binding]; other site 269796002642 substrate binding pocket [chemical binding]; other site 269796002643 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 269796002644 homodimer interface [polypeptide binding]; other site 269796002645 substrate-cofactor binding pocket; other site 269796002646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796002647 catalytic residue [active] 269796002648 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 269796002649 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 269796002650 dimer interface [polypeptide binding]; other site 269796002651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796002652 catalytic residue [active] 269796002653 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 269796002654 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 269796002655 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 269796002656 Walker A/P-loop; other site 269796002657 ATP binding site [chemical binding]; other site 269796002658 Q-loop/lid; other site 269796002659 ABC transporter signature motif; other site 269796002660 Walker B; other site 269796002661 D-loop; other site 269796002662 H-loop/switch region; other site 269796002663 NIL domain; Region: NIL; pfam09383 269796002664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796002665 dimer interface [polypeptide binding]; other site 269796002666 conserved gate region; other site 269796002667 ABC-ATPase subunit interface; other site 269796002668 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 269796002669 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269796002670 acyl-activating enzyme (AAE) consensus motif; other site 269796002671 AMP binding site [chemical binding]; other site 269796002672 active site 269796002673 CoA binding site [chemical binding]; other site 269796002674 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 269796002675 serine acetyltransferase; Provisional; Region: cysE; PRK11132 269796002676 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 269796002677 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 269796002678 trimer interface [polypeptide binding]; other site 269796002679 active site 269796002680 substrate binding site [chemical binding]; other site 269796002681 CoA binding site [chemical binding]; other site 269796002682 Nitrogenase_vnfN_like: VnfN subunit of the VnfEN complex-like. This group in addition to VnfN contains a subset of the beta subunit of the nitrogenase MoFe protein and NifN-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfN_like; cd01971 269796002683 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 269796002684 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 269796002685 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 269796002686 nitrogenase iron protein; Region: nifH; TIGR01287 269796002687 Nucleotide-binding sites [chemical binding]; other site 269796002688 Walker A motif; other site 269796002689 Switch I region of nucleotide binding site; other site 269796002690 Fe4S4 binding sites [ion binding]; other site 269796002691 Switch II region of nucleotide binding site; other site 269796002692 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796002693 Radical SAM superfamily; Region: Radical_SAM; pfam04055 269796002694 FeS/SAM binding site; other site 269796002695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796002696 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796002697 putative substrate translocation pore; other site 269796002698 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 269796002699 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 269796002700 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 269796002701 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 269796002702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796002703 dimer interface [polypeptide binding]; other site 269796002704 conserved gate region; other site 269796002705 putative PBP binding loops; other site 269796002706 ABC-ATPase subunit interface; other site 269796002707 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 269796002708 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 269796002709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796002710 dimer interface [polypeptide binding]; other site 269796002711 conserved gate region; other site 269796002712 putative PBP binding loops; other site 269796002713 ABC-ATPase subunit interface; other site 269796002714 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 269796002715 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796002716 Walker A/P-loop; other site 269796002717 ATP binding site [chemical binding]; other site 269796002718 Q-loop/lid; other site 269796002719 ABC transporter signature motif; other site 269796002720 Walker B; other site 269796002721 D-loop; other site 269796002722 H-loop/switch region; other site 269796002723 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 269796002724 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796002725 Walker A/P-loop; other site 269796002726 ATP binding site [chemical binding]; other site 269796002727 Q-loop/lid; other site 269796002728 ABC transporter signature motif; other site 269796002729 Walker B; other site 269796002730 D-loop; other site 269796002731 H-loop/switch region; other site 269796002732 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 269796002733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796002734 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 269796002735 dimerization interface [polypeptide binding]; other site 269796002736 substrate binding pocket [chemical binding]; other site 269796002737 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 269796002738 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 269796002739 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 269796002740 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 269796002741 Walker A motif; other site 269796002742 ATP binding site [chemical binding]; other site 269796002743 Walker B motif; other site 269796002744 AAA domain; Region: AAA_23; pfam13476 269796002745 Walker A/P-loop; other site 269796002746 ATP binding site [chemical binding]; other site 269796002747 Protein of Unknown function (DUF1690); Region: DUF1690; pfam07956 269796002748 Protein of unknown function (DUF3223); Region: DUF3223; pfam11523 269796002749 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 269796002750 RES domain; Region: RES; smart00953 269796002751 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 269796002752 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 269796002753 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 269796002754 Transposase, Mutator family; Region: Transposase_mut; cl19537 269796002755 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 269796002756 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 269796002757 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 269796002758 dimer interface [polypeptide binding]; other site 269796002759 active site 269796002760 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 269796002761 Ligand Binding Site [chemical binding]; other site 269796002762 Molecular Tunnel; other site 269796002763 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 269796002764 Hpr binding site; other site 269796002765 active site 269796002766 homohexamer subunit interaction site [polypeptide binding]; other site 269796002767 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 269796002768 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 269796002769 Cupin-like domain; Region: Cupin_8; cl19305 269796002770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 269796002771 Transposase, Mutator family; Region: Transposase_mut; cl19537 269796002772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796002773 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 269796002774 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 269796002775 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 269796002776 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 269796002777 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 269796002778 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 269796002779 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 269796002780 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 269796002781 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 269796002782 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 269796002783 Leucine rich repeat; Region: LRR_8; pfam13855 269796002784 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 269796002785 Leucine rich repeat; Region: LRR_8; pfam13855 269796002786 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 269796002787 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 269796002788 Leucine rich repeat; Region: LRR_8; pfam13855 269796002789 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 269796002790 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 269796002791 Leucine rich repeat; Region: LRR_8; pfam13855 269796002792 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 269796002793 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 269796002794 Leucine rich repeat; Region: LRR_8; pfam13855 269796002795 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 269796002796 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 269796002797 Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; Region: RocCOR; cd09914 269796002798 G1 box; other site 269796002799 GTP/Mg2+ binding site [chemical binding]; other site 269796002800 G2 box; other site 269796002801 Switch I region; other site 269796002802 G3 box; other site 269796002803 Switch II region; other site 269796002804 G4 box; other site 269796002805 G5 box; other site 269796002806 TIR domain; Region: TIR_2; cl17458 269796002807 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 269796002808 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 269796002809 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 269796002810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796002811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796002812 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796002813 putative substrate translocation pore; other site 269796002814 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 269796002815 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796002816 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269796002817 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269796002818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796002819 Walker A/P-loop; other site 269796002820 ATP binding site [chemical binding]; other site 269796002821 Q-loop/lid; other site 269796002822 ABC transporter signature motif; other site 269796002823 Walker B; other site 269796002824 D-loop; other site 269796002825 H-loop/switch region; other site 269796002826 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269796002827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796002828 Walker A/P-loop; other site 269796002829 ATP binding site [chemical binding]; other site 269796002830 Q-loop/lid; other site 269796002831 ABC transporter signature motif; other site 269796002832 Walker B; other site 269796002833 D-loop; other site 269796002834 H-loop/switch region; other site 269796002835 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 269796002836 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269796002837 N-terminal plug; other site 269796002838 ligand-binding site [chemical binding]; other site 269796002839 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 269796002840 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 269796002841 lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150 269796002842 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796002843 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 269796002844 active site 269796002845 metal-binding site [ion binding] 269796002846 nucleotide-binding site [chemical binding]; other site 269796002847 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 269796002848 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 269796002849 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 269796002850 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 269796002851 active site 269796002852 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 269796002853 Ligand Binding Site [chemical binding]; other site 269796002854 Molecular Tunnel; other site 269796002855 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 269796002856 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 269796002857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796002858 putative substrate translocation pore; other site 269796002859 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 269796002860 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269796002861 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796002862 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 269796002863 Outer membrane efflux protein; Region: OEP; pfam02321 269796002864 Outer membrane efflux protein; Region: OEP; pfam02321 269796002865 Transcriptional regulators [Transcription]; Region: MarR; COG1846 269796002866 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 269796002867 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 269796002868 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269796002869 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269796002870 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796002871 Walker A/P-loop; other site 269796002872 ATP binding site [chemical binding]; other site 269796002873 Q-loop/lid; other site 269796002874 ABC transporter signature motif; other site 269796002875 Walker B; other site 269796002876 D-loop; other site 269796002877 H-loop/switch region; other site 269796002878 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269796002879 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269796002880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796002881 Walker A/P-loop; other site 269796002882 ATP binding site [chemical binding]; other site 269796002883 Q-loop/lid; other site 269796002884 ABC transporter signature motif; other site 269796002885 Walker B; other site 269796002886 D-loop; other site 269796002887 H-loop/switch region; other site 269796002888 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 269796002889 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269796002890 N-terminal plug; other site 269796002891 ligand-binding site [chemical binding]; other site 269796002892 lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150 269796002893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796002894 Caspase domain; Region: Peptidase_C14; pfam00656 269796002895 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 269796002896 FOG: WD40 repeat [General function prediction only]; Region: COG2319 269796002897 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 269796002898 structural tetrad; other site 269796002899 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 269796002900 Caspase domain; Region: Peptidase_C14; pfam00656 269796002901 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 269796002902 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269796002903 ligand binding site [chemical binding]; other site 269796002904 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 269796002905 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 269796002906 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 269796002907 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 269796002908 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 269796002909 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269796002910 ABC transporter; Region: ABC_tran_2; pfam12848 269796002911 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269796002912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796002913 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 269796002914 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796002915 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 269796002916 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269796002917 N-terminal plug; other site 269796002918 ligand-binding site [chemical binding]; other site 269796002919 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269796002920 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269796002921 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796002922 Walker A/P-loop; other site 269796002923 ATP binding site [chemical binding]; other site 269796002924 Q-loop/lid; other site 269796002925 ABC transporter signature motif; other site 269796002926 Walker B; other site 269796002927 D-loop; other site 269796002928 H-loop/switch region; other site 269796002929 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269796002930 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269796002931 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796002932 Walker A/P-loop; other site 269796002933 ATP binding site [chemical binding]; other site 269796002934 Q-loop/lid; other site 269796002935 ABC transporter signature motif; other site 269796002936 Walker B; other site 269796002937 D-loop; other site 269796002938 H-loop/switch region; other site 269796002939 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 269796002940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269796002941 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 269796002942 DNA binding residues [nucleotide binding] 269796002943 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 269796002944 FecR protein; Region: FecR; pfam04773 269796002945 Secretin and TonB N terminus short domain; Region: STN; smart00965 269796002946 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 269796002947 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269796002948 N-terminal plug; other site 269796002949 ligand-binding site [chemical binding]; other site 269796002950 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 269796002951 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 269796002952 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269796002953 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796002954 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796002955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796002956 Domain of unknown function (DUF333); Region: DUF333; cl19829 269796002957 Integral membrane protein TerC family; Region: TerC; cl10468 269796002958 tellurite resistance protein terB; Region: terB; cd07176 269796002959 putative metal binding site [ion binding]; other site 269796002960 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 269796002961 putative metal binding site [ion binding]; other site 269796002962 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 269796002963 putative metal binding site [ion binding]; other site 269796002964 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 269796002965 putative metal binding site [ion binding]; other site 269796002966 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 269796002967 putative metal binding site [ion binding]; other site 269796002968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796002969 non-specific DNA binding site [nucleotide binding]; other site 269796002970 salt bridge; other site 269796002971 sequence-specific DNA binding site [nucleotide binding]; other site 269796002972 ATP-grasp in the biosynthetic pathway with Ter operon; Region: ATPgrasp_Ter; pfam15632 269796002973 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269796002974 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 269796002975 C-C_Bond_Lyase of the TIM-Barrel fold; Region: C-C_Bond_Lyase; pfam15617 269796002976 Phosphoribosyl transferase (PRTase); Region: PRTase_1; pfam11202 269796002977 PELOTA RNA binding domain; Region: PELOTA_1; pfam15608 269796002978 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 269796002979 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269796002980 active site 269796002981 TRSP domain C terminus to PRTase_2; Region: TRSP; pfam12500 269796002982 intracellular protease, PfpI family; Region: PfpI; TIGR01382 269796002983 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 269796002984 conserved cys residue [active] 269796002985 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 269796002986 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 269796002987 dimer interface [polypeptide binding]; other site 269796002988 active site 269796002989 glycine loop; other site 269796002990 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 269796002991 putative active site [active] 269796002992 metal binding site [ion binding]; metal-binding site 269796002993 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 269796002994 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 269796002995 Hexamer interface [polypeptide binding]; other site 269796002996 Hexagonal pore residue; other site 269796002997 propanediol utilization protein PduB; Provisional; Region: PRK15415 269796002998 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 269796002999 putative hexamer interface [polypeptide binding]; other site 269796003000 putative hexagonal pore; other site 269796003001 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 269796003002 putative hexamer interface [polypeptide binding]; other site 269796003003 putative hexagonal pore; other site 269796003004 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 269796003005 Hexamer interface [polypeptide binding]; other site 269796003006 Hexagonal pore residue; other site 269796003007 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 269796003008 Hexamer interface [polypeptide binding]; other site 269796003009 Hexagonal pore residue; other site 269796003010 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 269796003011 Propanediol utilisation protein PduL; Region: PduL; pfam06130 269796003012 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 269796003013 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 269796003014 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 269796003015 nucleotide binding site [chemical binding]; other site 269796003016 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 269796003017 nucleotide binding site [chemical binding]; other site 269796003018 Flavoprotein; Region: Flavoprotein; cl19190 269796003019 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 269796003020 Hexamer/Pentamer interface [polypeptide binding]; other site 269796003021 central pore; other site 269796003022 Domain of unknown function (DUF336); Region: DUF336; pfam03928 269796003023 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 269796003024 putative catalytic cysteine [active] 269796003025 Bacterial Micro-Compartment (BMC)-like domain 2; Region: BMC_like_2; cd07055 269796003026 putative hexamer interface [polypeptide binding]; other site 269796003027 putative hexagonal pore; other site 269796003028 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 269796003029 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 269796003030 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 269796003031 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 269796003032 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 269796003033 S-adenosylmethionine synthetase; Validated; Region: PRK05250 269796003034 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 269796003035 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 269796003036 Sensory domain found in PocR; Region: PocR; pfam10114 269796003037 Histidine kinase; Region: His_kinase; pfam06580 269796003038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796003039 ATP binding site [chemical binding]; other site 269796003040 Mg2+ binding site [ion binding]; other site 269796003041 G-X-G motif; other site 269796003042 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 269796003043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796003044 active site 269796003045 phosphorylation site [posttranslational modification] 269796003046 intermolecular recognition site; other site 269796003047 dimerization interface [polypeptide binding]; other site 269796003048 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796003049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796003050 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 269796003051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796003052 non-specific DNA binding site [nucleotide binding]; other site 269796003053 salt bridge; other site 269796003054 sequence-specific DNA binding site [nucleotide binding]; other site 269796003055 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 269796003056 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 269796003057 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 269796003058 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 269796003059 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796003060 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 269796003061 active site 269796003062 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 269796003063 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 269796003064 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 269796003065 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 269796003066 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 269796003067 dimer interface [polypeptide binding]; other site 269796003068 active site 269796003069 metal binding site [ion binding]; metal-binding site 269796003070 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 269796003071 NAD(P) binding site [chemical binding]; other site 269796003072 catalytic residues [active] 269796003073 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 269796003074 GAF domain; Region: GAF; pfam01590 269796003075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796003076 Walker A motif; other site 269796003077 ATP binding site [chemical binding]; other site 269796003078 Walker B motif; other site 269796003079 arginine finger; other site 269796003080 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269796003081 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 269796003082 inhibitor-cofactor binding pocket; inhibition site 269796003083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796003084 catalytic residue [active] 269796003085 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269796003086 active site 269796003087 putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325 269796003088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269796003089 NAD(P) binding site [chemical binding]; other site 269796003090 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 269796003091 active site 269796003092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 269796003093 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 269796003094 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 269796003095 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 269796003096 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 269796003097 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 269796003098 active site 269796003099 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 269796003100 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 269796003101 nucleotide binding pocket [chemical binding]; other site 269796003102 K-X-D-G motif; other site 269796003103 catalytic site [active] 269796003104 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 269796003105 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 269796003106 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 269796003107 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 269796003108 Dimer interface [polypeptide binding]; other site 269796003109 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 269796003110 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 269796003111 Walker A/P-loop; other site 269796003112 ATP binding site [chemical binding]; other site 269796003113 Q-loop/lid; other site 269796003114 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 269796003115 ABC transporter signature motif; other site 269796003116 Walker B; other site 269796003117 D-loop; other site 269796003118 H-loop/switch region; other site 269796003119 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 269796003120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796003121 binding surface 269796003122 TPR motif; other site 269796003123 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 269796003124 Rnk N-terminus; Region: Rnk_N; pfam14760 269796003125 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 269796003126 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 269796003127 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 269796003128 cell division protein FtsZ; Validated; Region: PRK09330 269796003129 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 269796003130 nucleotide binding site [chemical binding]; other site 269796003131 SulA interaction site; other site 269796003132 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 269796003133 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 269796003134 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 269796003135 nucleotide binding site [chemical binding]; other site 269796003136 Cell division protein FtsA; Region: FtsA; pfam14450 269796003137 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 269796003138 Cell division protein FtsQ; Region: FtsQ; pfam03799 269796003139 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 269796003140 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 269796003141 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269796003142 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 269796003143 FAD binding domain; Region: FAD_binding_4; cl19922 269796003144 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 269796003145 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 269796003146 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 269796003147 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 269796003148 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 269796003149 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 269796003150 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 269796003151 active site 269796003152 homodimer interface [polypeptide binding]; other site 269796003153 cell division protein FtsW; Region: ftsW; TIGR02614 269796003154 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 269796003155 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 269796003156 NAD binding site [chemical binding]; other site 269796003157 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 269796003158 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 269796003159 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 269796003160 Mg++ binding site [ion binding]; other site 269796003161 putative catalytic motif [active] 269796003162 putative substrate binding site [chemical binding]; other site 269796003163 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 269796003164 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 269796003165 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 269796003166 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 269796003167 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 269796003168 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 269796003169 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 269796003170 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 269796003171 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 269796003172 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 269796003173 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 269796003174 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 269796003175 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 269796003176 MraZ protein; Region: MraZ; pfam02381 269796003177 MraZ protein; Region: MraZ; pfam02381 269796003178 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 269796003179 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 269796003180 amidase catalytic site [active] 269796003181 Zn binding residues [ion binding]; other site 269796003182 substrate binding site [chemical binding]; other site 269796003183 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 269796003184 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 269796003185 putative metal binding site [ion binding]; other site 269796003186 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 269796003187 HSP70 interaction site [polypeptide binding]; other site 269796003188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269796003189 Coenzyme A binding pocket [chemical binding]; other site 269796003190 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 269796003191 trimerization site [polypeptide binding]; other site 269796003192 active site 269796003193 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 269796003194 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 269796003195 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 269796003196 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 269796003197 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 269796003198 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 269796003199 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 269796003200 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 269796003201 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 269796003202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796003203 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 269796003204 Walker A motif; other site 269796003205 ATP binding site [chemical binding]; other site 269796003206 Walker B motif; other site 269796003207 arginine finger; other site 269796003208 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 269796003209 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 269796003210 metal ion-dependent adhesion site (MIDAS); other site 269796003211 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 269796003212 XdhC Rossmann domain; Region: XdhC_C; pfam13478 269796003213 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 269796003214 putative MPT binding site; other site 269796003215 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 269796003216 Ligand binding site; other site 269796003217 metal-binding site 269796003218 arogenate dehydrogenase; Region: PLN02256 269796003219 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 269796003220 Uncharacterized conserved protein [Function unknown]; Region: COG3461 269796003221 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 269796003222 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 269796003223 PemK-like protein; Region: PemK; pfam02452 269796003224 RelB antitoxin; Region: RelB; cl01171 269796003225 Transcriptional regulators [Transcription]; Region: MarR; COG1846 269796003226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 269796003227 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 269796003228 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 269796003229 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 269796003230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796003231 dimer interface [polypeptide binding]; other site 269796003232 conserved gate region; other site 269796003233 putative PBP binding loops; other site 269796003234 ABC-ATPase subunit interface; other site 269796003235 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 269796003236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796003237 dimer interface [polypeptide binding]; other site 269796003238 conserved gate region; other site 269796003239 putative PBP binding loops; other site 269796003240 ABC-ATPase subunit interface; other site 269796003241 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 269796003242 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796003243 Walker A/P-loop; other site 269796003244 ATP binding site [chemical binding]; other site 269796003245 Q-loop/lid; other site 269796003246 ABC transporter signature motif; other site 269796003247 Walker B; other site 269796003248 D-loop; other site 269796003249 H-loop/switch region; other site 269796003250 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 269796003251 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796003252 Walker A/P-loop; other site 269796003253 ATP binding site [chemical binding]; other site 269796003254 Q-loop/lid; other site 269796003255 ABC transporter signature motif; other site 269796003256 Walker B; other site 269796003257 D-loop; other site 269796003258 H-loop/switch region; other site 269796003259 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 269796003260 amidase; Provisional; Region: PRK07486 269796003261 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 269796003262 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 269796003263 metal binding site [ion binding]; metal-binding site 269796003264 putative dimer interface [polypeptide binding]; other site 269796003265 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796003266 metal binding site [ion binding]; metal-binding site 269796003267 active site 269796003268 I-site; other site 269796003269 AAA domain; Region: AAA_28; pfam13521 269796003270 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 269796003271 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 269796003272 C-terminal domain interface [polypeptide binding]; other site 269796003273 GSH binding site (G-site) [chemical binding]; other site 269796003274 dimer interface [polypeptide binding]; other site 269796003275 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 269796003276 dimer interface [polypeptide binding]; other site 269796003277 N-terminal domain interface [polypeptide binding]; other site 269796003278 putative substrate binding pocket (H-site) [chemical binding]; other site 269796003279 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 269796003280 ligand binding site [chemical binding]; other site 269796003281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796003282 dimerization interface [polypeptide binding]; other site 269796003283 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796003284 metal binding site [ion binding]; metal-binding site 269796003285 active site 269796003286 I-site; other site 269796003287 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796003288 Predicted membrane protein [Function unknown]; Region: COG2860 269796003289 UPF0126 domain; Region: UPF0126; pfam03458 269796003290 UPF0126 domain; Region: UPF0126; pfam03458 269796003291 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 269796003292 Nif-specific regulatory protein; Region: nifA; TIGR01817 269796003293 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269796003294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796003295 Walker A motif; other site 269796003296 ATP binding site [chemical binding]; other site 269796003297 Walker B motif; other site 269796003298 arginine finger; other site 269796003299 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269796003300 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 269796003301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796003302 FeS/SAM binding site; other site 269796003303 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 269796003304 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 269796003305 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 269796003306 HEAT repeats; Region: HEAT_2; pfam13646 269796003307 NifZ domain; Region: NifZ; pfam04319 269796003308 probable nitrogen fixation protein FixT; Region: nifT_nitrog; TIGR02934 269796003309 SIR2-like domain; Region: SIR2_2; pfam13289 269796003310 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 269796003311 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 269796003312 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 269796003313 Walker A/P-loop; other site 269796003314 ATP binding site [chemical binding]; other site 269796003315 Q-loop/lid; other site 269796003316 ABC transporter signature motif; other site 269796003317 Walker B; other site 269796003318 D-loop; other site 269796003319 H-loop/switch region; other site 269796003320 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 269796003321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796003322 dimer interface [polypeptide binding]; other site 269796003323 conserved gate region; other site 269796003324 putative PBP binding loops; other site 269796003325 ABC-ATPase subunit interface; other site 269796003326 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 269796003327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 269796003328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796003329 putative PBP binding loops; other site 269796003330 dimer interface [polypeptide binding]; other site 269796003331 ABC-ATPase subunit interface; other site 269796003332 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 269796003333 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 269796003334 substrate binding pocket [chemical binding]; other site 269796003335 membrane-bound complex binding site; other site 269796003336 hinge residues; other site 269796003337 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 269796003338 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 269796003339 Ligand binding site; other site 269796003340 Putative Catalytic site; other site 269796003341 DXD motif; other site 269796003342 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 269796003343 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 269796003344 putative catalytic residues [active] 269796003345 ADP-ribosyl-[dinitrogen reductase] hydrolase; Region: dinitro_DRAG; TIGR02662 269796003346 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 269796003347 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 269796003348 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 269796003349 Nucleotide-binding sites [chemical binding]; other site 269796003350 Walker A motif; other site 269796003351 Switch I region of nucleotide binding site; other site 269796003352 Fe4S4 binding sites [ion binding]; other site 269796003353 Switch II region of nucleotide binding site; other site 269796003354 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 269796003355 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 269796003356 MoFe protein alpha/beta subunit interactions; other site 269796003357 Alpha subunit P cluster binding residues; other site 269796003358 FeMoco binding residues [chemical binding]; other site 269796003359 MoFe protein alpha subunit/Fe protein contacts; other site 269796003360 MoFe protein dimer/ dimer interactions; other site 269796003361 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 269796003362 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 269796003363 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 269796003364 MoFe protein beta/alpha subunit interactions; other site 269796003365 Beta subunit P cluster binding residues; other site 269796003366 MoFe protein beta subunit/Fe protein contacts; other site 269796003367 MoFe protein dimer/ dimer interactions; other site 269796003368 ABC transporter ATPase component; Reviewed; Region: PRK11147 269796003369 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269796003370 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269796003371 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 269796003372 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 269796003373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796003374 dimer interface [polypeptide binding]; other site 269796003375 conserved gate region; other site 269796003376 putative PBP binding loops; other site 269796003377 ABC-ATPase subunit interface; other site 269796003378 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 269796003379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796003380 dimer interface [polypeptide binding]; other site 269796003381 conserved gate region; other site 269796003382 putative PBP binding loops; other site 269796003383 ABC-ATPase subunit interface; other site 269796003384 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 269796003385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796003386 Walker A/P-loop; other site 269796003387 ATP binding site [chemical binding]; other site 269796003388 Q-loop/lid; other site 269796003389 ABC transporter signature motif; other site 269796003390 Walker B; other site 269796003391 D-loop; other site 269796003392 H-loop/switch region; other site 269796003393 TOBE domain; Region: TOBE_2; pfam08402 269796003394 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 269796003395 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 269796003396 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 269796003397 Cytochrome c; Region: Cytochrom_C; cl11414 269796003398 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 269796003399 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 269796003400 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269796003401 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269796003402 DNA binding residues [nucleotide binding] 269796003403 Helix-turn-helix domain; Region: HTH_39; pfam14090 269796003404 Predicted transcriptional regulator [Transcription]; Region: COG2932 269796003405 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796003406 sequence-specific DNA binding site [nucleotide binding]; other site 269796003407 salt bridge; other site 269796003408 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 269796003409 Catalytic site [active] 269796003410 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 269796003411 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 269796003412 DNA binding residues [nucleotide binding] 269796003413 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 269796003414 dimer interface [polypeptide binding]; other site 269796003415 putative metal binding site [ion binding]; other site 269796003416 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 269796003417 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 269796003418 metal-binding site [ion binding] 269796003419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 269796003420 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 269796003421 Soluble P-type ATPase [General function prediction only]; Region: COG4087 269796003422 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 269796003423 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 269796003424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796003425 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 269796003426 ethanolamine permease; Region: 2A0305; TIGR00908 269796003427 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 269796003428 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 269796003429 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 269796003430 dimerization interface [polypeptide binding]; other site 269796003431 metal binding site [ion binding]; metal-binding site 269796003432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796003433 PAS domain; Region: PAS_9; pfam13426 269796003434 putative active site [active] 269796003435 heme pocket [chemical binding]; other site 269796003436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796003437 ATP binding site [chemical binding]; other site 269796003438 Mg2+ binding site [ion binding]; other site 269796003439 G-X-G motif; other site 269796003440 PAS fold; Region: PAS_3; pfam08447 269796003441 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796003442 metal binding site [ion binding]; metal-binding site 269796003443 active site 269796003444 I-site; other site 269796003445 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796003446 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 269796003447 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 269796003448 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 269796003449 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 269796003450 active site 269796003451 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 269796003452 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 269796003453 active site 269796003454 nucleophile elbow; other site 269796003455 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 269796003456 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 269796003457 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 269796003458 NAD binding site [chemical binding]; other site 269796003459 Phe binding site; other site 269796003460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796003461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796003462 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 269796003463 putative effector binding pocket; other site 269796003464 dimerization interface [polypeptide binding]; other site 269796003465 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 269796003466 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 269796003467 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 269796003468 active site 269796003469 catalytic residues [active] 269796003470 metal binding site [ion binding]; metal-binding site 269796003471 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 269796003472 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 269796003473 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 269796003474 acyl-activating enzyme (AAE) consensus motif; other site 269796003475 putative AMP binding site [chemical binding]; other site 269796003476 putative active site [active] 269796003477 putative CoA binding site [chemical binding]; other site 269796003478 6-phosphofructokinase; Provisional; Region: PRK14071 269796003479 active site 269796003480 ADP/pyrophosphate binding site [chemical binding]; other site 269796003481 dimerization interface [polypeptide binding]; other site 269796003482 allosteric effector site; other site 269796003483 fructose-1,6-bisphosphate binding site; other site 269796003484 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 269796003485 AIR carboxylase; Region: AIRC; pfam00731 269796003486 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 269796003487 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269796003488 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796003489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796003490 active site 269796003491 phosphorylation site [posttranslational modification] 269796003492 intermolecular recognition site; other site 269796003493 dimerization interface [polypeptide binding]; other site 269796003494 PAS domain; Region: PAS; smart00091 269796003495 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796003496 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796003497 dimer interface [polypeptide binding]; other site 269796003498 putative CheW interface [polypeptide binding]; other site 269796003499 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 269796003500 Protein of unknown function (DUF1013); Region: DUF1013; pfam06242 269796003501 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 269796003502 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 269796003503 NAD(P) binding site [chemical binding]; other site 269796003504 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 269796003505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269796003506 NAD(P) binding site [chemical binding]; other site 269796003507 active site 269796003508 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 269796003509 active site 269796003510 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 269796003511 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 269796003512 active site 269796003513 catalytic tetrad [active] 269796003514 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796003515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796003516 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 269796003517 dimerization interface [polypeptide binding]; other site 269796003518 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 269796003519 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 269796003520 oligomeric interface; other site 269796003521 putative active site [active] 269796003522 homodimer interface [polypeptide binding]; other site 269796003523 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 269796003524 Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549 269796003525 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269796003526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796003527 sequence-specific DNA binding site [nucleotide binding]; other site 269796003528 salt bridge; other site 269796003529 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 269796003530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796003531 Walker A/P-loop; other site 269796003532 ATP binding site [chemical binding]; other site 269796003533 Q-loop/lid; other site 269796003534 ABC transporter signature motif; other site 269796003535 Walker B; other site 269796003536 H-loop/switch region; other site 269796003537 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796003538 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 269796003539 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269796003540 catalytic residue [active] 269796003541 Predicted Fe-S protein [General function prediction only]; Region: COG2000 269796003542 Putative Fe-S cluster; Region: FeS; cl17515 269796003543 Src Homology 3 domain superfamily; Region: SH3; cl17036 269796003544 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 269796003545 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 269796003546 putative dimer interface [polypeptide binding]; other site 269796003547 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 269796003548 cyclase homology domain; Region: CHD; cd07302 269796003549 nucleotidyl binding site; other site 269796003550 metal binding site [ion binding]; metal-binding site 269796003551 dimer interface [polypeptide binding]; other site 269796003552 ribosomal protein L31; Region: L31; TIGR00105 269796003553 hypothetical protein; Validated; Region: PRK09039 269796003554 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 269796003555 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269796003556 ligand binding site [chemical binding]; other site 269796003557 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269796003558 ligand binding site [chemical binding]; other site 269796003559 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 269796003560 active site 269796003561 dimerization interface [polypeptide binding]; other site 269796003562 translation elongation factor P; Region: efp; TIGR00038 269796003563 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 269796003564 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 269796003565 RNA binding site [nucleotide binding]; other site 269796003566 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 269796003567 RNA binding site [nucleotide binding]; other site 269796003568 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 269796003569 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 269796003570 motif 1; other site 269796003571 dimer interface [polypeptide binding]; other site 269796003572 active site 269796003573 motif 2; other site 269796003574 motif 3; other site 269796003575 potassium/proton antiporter; Reviewed; Region: PRK05326 269796003576 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 269796003577 Transporter associated domain; Region: CorC_HlyC; smart01091 269796003578 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 269796003579 thiamine phosphate binding site [chemical binding]; other site 269796003580 active site 269796003581 pyrophosphate binding site [ion binding]; other site 269796003582 Cell division protein ZapA; Region: ZapA; cl01146 269796003583 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 269796003584 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 269796003585 putative active site [active] 269796003586 metal binding site [ion binding]; metal-binding site 269796003587 homodimer binding site [polypeptide binding]; other site 269796003588 hypothetical protein; Validated; Region: PRK00110 269796003589 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 269796003590 active site 269796003591 putative DNA-binding cleft [nucleotide binding]; other site 269796003592 dimer interface [polypeptide binding]; other site 269796003593 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 269796003594 RuvA N terminal domain; Region: RuvA_N; pfam01330 269796003595 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 269796003596 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 269796003597 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 269796003598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 269796003599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796003600 Walker A motif; other site 269796003601 ATP binding site [chemical binding]; other site 269796003602 Walker B motif; other site 269796003603 arginine finger; other site 269796003604 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 269796003605 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 269796003606 active site 269796003607 TolQ protein; Region: tolQ; TIGR02796 269796003608 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 269796003609 TolA protein; Region: tolA_full; TIGR02794 269796003610 TonB C terminal; Region: TonB_2; pfam13103 269796003611 translocation protein TolB; Provisional; Region: tolB; PRK05137 269796003612 TolB amino-terminal domain; Region: TolB_N; pfam04052 269796003613 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 269796003614 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 269796003615 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269796003616 ligand binding site [chemical binding]; other site 269796003617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796003618 binding surface 269796003619 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 269796003620 TPR motif; other site 269796003621 Tetratricopeptide repeat; Region: TPR_6; pfam13174 269796003622 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 269796003623 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 269796003624 Ligand Binding Site [chemical binding]; other site 269796003625 FtsH Extracellular; Region: FtsH_ext; pfam06480 269796003626 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 269796003627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796003628 Walker A motif; other site 269796003629 ATP binding site [chemical binding]; other site 269796003630 Walker B motif; other site 269796003631 arginine finger; other site 269796003632 Peptidase family M41; Region: Peptidase_M41; pfam01434 269796003633 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 269796003634 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 269796003635 substrate binding pocket [chemical binding]; other site 269796003636 dimer interface [polypeptide binding]; other site 269796003637 inhibitor binding site; inhibition site 269796003638 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 269796003639 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 269796003640 active site 269796003641 substrate binding site [chemical binding]; other site 269796003642 metal binding site [ion binding]; metal-binding site 269796003643 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 269796003644 YlqD protein; Region: YlqD; pfam11068 269796003645 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 269796003646 dimer interface [polypeptide binding]; other site 269796003647 substrate binding site [chemical binding]; other site 269796003648 ATP binding site [chemical binding]; other site 269796003649 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 269796003650 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 269796003651 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 269796003652 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269796003653 catalytic residue [active] 269796003654 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 269796003655 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 269796003656 motif 1; other site 269796003657 dimer interface [polypeptide binding]; other site 269796003658 active site 269796003659 motif 2; other site 269796003660 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 269796003661 GDP-binding site [chemical binding]; other site 269796003662 ACT binding site; other site 269796003663 IMP binding site; other site 269796003664 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 269796003665 ATP binding site [chemical binding]; other site 269796003666 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 269796003667 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269796003668 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796003669 dimerization interface [polypeptide binding]; other site 269796003670 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796003671 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796003672 dimer interface [polypeptide binding]; other site 269796003673 putative CheW interface [polypeptide binding]; other site 269796003674 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 269796003675 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 269796003676 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269796003677 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 269796003678 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269796003679 DNA binding residues [nucleotide binding] 269796003680 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 269796003681 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269796003682 RNA binding surface [nucleotide binding]; other site 269796003683 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 269796003684 active site 269796003685 Zonular occludens toxin (Zot); Region: Zot; cl17485 269796003686 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 269796003687 MPN+ (JAMM) motif; other site 269796003688 Zinc-binding site [ion binding]; other site 269796003689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796003690 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796003691 putative substrate translocation pore; other site 269796003692 Helix-turn-helix domain; Region: HTH_31; pfam13560 269796003693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796003694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796003695 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 269796003696 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269796003697 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796003698 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 269796003699 MMPL family; Region: MMPL; cl14618 269796003700 NnrS protein; Region: NnrS; pfam05940 269796003701 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269796003702 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 269796003703 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 269796003704 Walker A/P-loop; other site 269796003705 ATP binding site [chemical binding]; other site 269796003706 Q-loop/lid; other site 269796003707 ABC transporter signature motif; other site 269796003708 Walker B; other site 269796003709 D-loop; other site 269796003710 H-loop/switch region; other site 269796003711 pyruvate carboxylase; Reviewed; Region: PRK12999 269796003712 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269796003713 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269796003714 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 269796003715 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 269796003716 active site 269796003717 catalytic residues [active] 269796003718 metal binding site [ion binding]; metal-binding site 269796003719 homodimer binding site [polypeptide binding]; other site 269796003720 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 269796003721 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 269796003722 carboxyltransferase (CT) interaction site; other site 269796003723 biotinylation site [posttranslational modification]; other site 269796003724 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 269796003725 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 269796003726 putative deacylase active site [active] 269796003727 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 269796003728 FAD binding domain; Region: FAD_binding_4; pfam01565 269796003729 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 269796003730 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269796003731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796003732 non-specific DNA binding site [nucleotide binding]; other site 269796003733 salt bridge; other site 269796003734 sequence-specific DNA binding site [nucleotide binding]; other site 269796003735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 269796003736 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 269796003737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 269796003738 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 269796003739 Integrase core domain; Region: rve; pfam00665 269796003740 Integrase core domain; Region: rve_3; pfam13683 269796003741 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 269796003742 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 269796003743 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 269796003744 homodimer interface [polypeptide binding]; other site 269796003745 substrate-cofactor binding pocket; other site 269796003746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796003747 catalytic residue [active] 269796003748 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 269796003749 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 269796003750 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 269796003751 excinuclease ABC subunit B; Provisional; Region: PRK05298 269796003752 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269796003753 ATP binding site [chemical binding]; other site 269796003754 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269796003755 nucleotide binding region [chemical binding]; other site 269796003756 ATP-binding site [chemical binding]; other site 269796003757 Ultra-violet resistance protein B; Region: UvrB; pfam12344 269796003758 UvrB/uvrC motif; Region: UVR; pfam02151 269796003759 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 269796003760 Cation transport protein; Region: TrkH; cl17365 269796003761 aspartate aminotransferase; Provisional; Region: PRK05764 269796003762 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269796003763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796003764 homodimer interface [polypeptide binding]; other site 269796003765 catalytic residue [active] 269796003766 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 269796003767 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 269796003768 intersubunit interface [polypeptide binding]; other site 269796003769 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 269796003770 ABC-ATPase subunit interface; other site 269796003771 dimer interface [polypeptide binding]; other site 269796003772 putative PBP binding regions; other site 269796003773 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 269796003774 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 269796003775 Walker A/P-loop; other site 269796003776 ATP binding site [chemical binding]; other site 269796003777 Q-loop/lid; other site 269796003778 ABC transporter signature motif; other site 269796003779 Walker B; other site 269796003780 D-loop; other site 269796003781 H-loop/switch region; other site 269796003782 Pseudoazurin (Paz) is a type I blue copper electron-transfer protein; Region: Pseudoazurin; cd04218 269796003783 Type 1 (T1) Cu binding site [ion binding]; other site 269796003784 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 269796003785 elongation factor G; Reviewed; Region: PRK12740 269796003786 G1 box; other site 269796003787 putative GEF interaction site [polypeptide binding]; other site 269796003788 GTP/Mg2+ binding site [chemical binding]; other site 269796003789 Switch I region; other site 269796003790 G2 box; other site 269796003791 G3 box; other site 269796003792 Switch II region; other site 269796003793 G4 box; other site 269796003794 G5 box; other site 269796003795 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 269796003796 Elongation Factor G, domain II; Region: EFG_II; pfam14492 269796003797 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 269796003798 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 269796003799 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 269796003800 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 269796003801 catalytic residue [active] 269796003802 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 269796003803 dimer interface [polypeptide binding]; other site 269796003804 active site 269796003805 glycine-pyridoxal phosphate binding site [chemical binding]; other site 269796003806 folate binding site [chemical binding]; other site 269796003807 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 269796003808 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 269796003809 DNA-binding site [nucleotide binding]; DNA binding site 269796003810 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269796003811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796003812 homodimer interface [polypeptide binding]; other site 269796003813 catalytic residue [active] 269796003814 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 269796003815 Sulfate transporter family; Region: Sulfate_transp; cl19250 269796003816 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 269796003817 dimer interface [polypeptide binding]; other site 269796003818 pyridoxal binding site [chemical binding]; other site 269796003819 ATP binding site [chemical binding]; other site 269796003820 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 269796003821 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 269796003822 substrate-cofactor binding pocket; other site 269796003823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796003824 catalytic residue [active] 269796003825 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 269796003826 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 269796003827 inhibitor-cofactor binding pocket; inhibition site 269796003828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796003829 catalytic residue [active] 269796003830 RAMP superfamily; Region: RAMPs; cl19153 269796003831 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 269796003832 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 269796003833 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 269796003834 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 269796003835 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 269796003836 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 269796003837 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 269796003838 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 269796003839 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 269796003840 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 269796003841 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 269796003842 Soluble P-type ATPase [General function prediction only]; Region: COG4087 269796003843 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 269796003844 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 269796003845 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 269796003846 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 269796003847 Ligand Binding Site [chemical binding]; other site 269796003848 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 269796003849 GAF domain; Region: GAF_3; pfam13492 269796003850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796003851 dimer interface [polypeptide binding]; other site 269796003852 phosphorylation site [posttranslational modification] 269796003853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796003854 ATP binding site [chemical binding]; other site 269796003855 Mg2+ binding site [ion binding]; other site 269796003856 G-X-G motif; other site 269796003857 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 269796003858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796003859 active site 269796003860 phosphorylation site [posttranslational modification] 269796003861 intermolecular recognition site; other site 269796003862 dimerization interface [polypeptide binding]; other site 269796003863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269796003864 DNA binding site [nucleotide binding] 269796003865 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269796003866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796003867 dimerization interface [polypeptide binding]; other site 269796003868 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796003869 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796003870 dimer interface [polypeptide binding]; other site 269796003871 putative CheW interface [polypeptide binding]; other site 269796003872 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 269796003873 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 269796003874 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 269796003875 hydrogenase 1 large subunit; Provisional; Region: PRK10170 269796003876 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 269796003877 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 269796003878 putative substrate-binding site; other site 269796003879 nickel binding site [ion binding]; other site 269796003880 HupF/HypC family; Region: HupF_HypC; pfam01455 269796003881 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 269796003882 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174 269796003883 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 269796003884 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796003885 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269796003886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796003887 active site 269796003888 phosphorylation site [posttranslational modification] 269796003889 intermolecular recognition site; other site 269796003890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796003891 Walker A motif; other site 269796003892 ATP binding site [chemical binding]; other site 269796003893 Walker B motif; other site 269796003894 arginine finger; other site 269796003895 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 269796003896 Predicted transcriptional regulator [Transcription]; Region: COG1959 269796003897 Rrf2 family protein; Region: rrf2_super; TIGR00738 269796003898 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 269796003899 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 269796003900 putative DNA binding site [nucleotide binding]; other site 269796003901 putative Zn2+ binding site [ion binding]; other site 269796003902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796003903 TPR motif; other site 269796003904 binding surface 269796003905 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796003906 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 269796003907 homotrimer interaction site [polypeptide binding]; other site 269796003908 putative active site [active] 269796003909 CsbD-like; Region: CsbD; cl17424 269796003910 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 269796003911 active site 269796003912 Zn binding site [ion binding]; other site 269796003913 Protoglobin; Region: Protoglobin; pfam11563 269796003914 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796003915 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796003916 dimer interface [polypeptide binding]; other site 269796003917 putative CheW interface [polypeptide binding]; other site 269796003918 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 269796003919 motif 1; other site 269796003920 dimer interface [polypeptide binding]; other site 269796003921 active site 269796003922 motif 2; other site 269796003923 motif 3; other site 269796003924 Anticodon binding domain; Region: HGTP_anticodon; pfam03129 269796003925 anticodon binding site; other site 269796003926 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 269796003927 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 269796003928 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 269796003929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796003930 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796003931 putative substrate translocation pore; other site 269796003932 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 269796003933 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 269796003934 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 269796003935 P loop; other site 269796003936 GTP binding site [chemical binding]; other site 269796003937 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 269796003938 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 269796003939 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796003940 FeS/SAM binding site; other site 269796003941 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 269796003942 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 269796003943 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 269796003944 signal recognition particle protein; Provisional; Region: PRK10867 269796003945 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 269796003946 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 269796003947 P loop; other site 269796003948 GTP binding site [chemical binding]; other site 269796003949 Signal peptide binding domain; Region: SRP_SPB; pfam02978 269796003950 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 269796003951 RimM N-terminal domain; Region: RimM; pfam01782 269796003952 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 269796003953 PRC-barrel domain; Region: PRC; pfam05239 269796003954 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 269796003955 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 269796003956 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 269796003957 substrate binding site [chemical binding]; other site 269796003958 ligand binding site [chemical binding]; other site 269796003959 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 269796003960 substrate binding site [chemical binding]; other site 269796003961 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 269796003962 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 269796003963 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 269796003964 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 269796003965 [2Fe-2S] cluster binding site [ion binding]; other site 269796003966 Uncharacterized conserved protein [Function unknown]; Region: COG1433 269796003967 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 269796003968 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 269796003969 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 269796003970 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 269796003971 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 269796003972 Nitrate and nitrite sensing; Region: NIT; pfam08376 269796003973 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796003974 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796003975 dimer interface [polypeptide binding]; other site 269796003976 putative CheW interface [polypeptide binding]; other site 269796003977 LysE type translocator; Region: LysE; cl00565 269796003978 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 269796003979 pyridoxal binding site [chemical binding]; other site 269796003980 dimer interface [polypeptide binding]; other site 269796003981 ATP binding site [chemical binding]; other site 269796003982 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 269796003983 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 269796003984 putative active site [active] 269796003985 putative catalytic site [active] 269796003986 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 269796003987 putative active site [active] 269796003988 putative catalytic site [active] 269796003989 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 269796003990 Iron-sulfur protein interface; other site 269796003991 proximal quinone binding site [chemical binding]; other site 269796003992 SdhD (CybS) interface [polypeptide binding]; other site 269796003993 proximal heme binding site [chemical binding]; other site 269796003994 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 269796003995 putative SdhC subunit interface [polypeptide binding]; other site 269796003996 putative proximal heme binding site [chemical binding]; other site 269796003997 putative Iron-sulfur protein interface [polypeptide binding]; other site 269796003998 putative proximal quinone binding site; other site 269796003999 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 269796004000 L-aspartate oxidase; Provisional; Region: PRK06175 269796004001 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 269796004002 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 269796004003 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 269796004004 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 269796004005 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 269796004006 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 269796004007 Predicted ATPase [General function prediction only]; Region: COG1485 269796004008 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 269796004009 Chromate transporter; Region: Chromate_transp; cl17781 269796004010 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 269796004011 Chromate transporter; Region: Chromate_transp; cl17781 269796004012 malate dehydrogenase; Reviewed; Region: PRK06223 269796004013 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 269796004014 NAD(P) binding site [chemical binding]; other site 269796004015 dimer interface [polypeptide binding]; other site 269796004016 tetramer (dimer of dimers) interface [polypeptide binding]; other site 269796004017 substrate binding site [chemical binding]; other site 269796004018 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 269796004019 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 269796004020 CoA-ligase; Region: Ligase_CoA; pfam00549 269796004021 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 269796004022 CoA binding domain; Region: CoA_binding; pfam02629 269796004023 CoA-ligase; Region: Ligase_CoA; pfam00549 269796004024 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 269796004025 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 269796004026 TPP-binding site [chemical binding]; other site 269796004027 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 269796004028 dimer interface [polypeptide binding]; other site 269796004029 PYR/PP interface [polypeptide binding]; other site 269796004030 TPP binding site [chemical binding]; other site 269796004031 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 269796004032 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 269796004033 E3 interaction surface; other site 269796004034 lipoyl attachment site [posttranslational modification]; other site 269796004035 e3 binding domain; Region: E3_binding; pfam02817 269796004036 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 269796004037 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 269796004038 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269796004039 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 269796004040 phage shock protein C; Region: phageshock_pspC; TIGR02978 269796004041 PspC domain; Region: PspC; cl00864 269796004042 Phage shock protein B; Region: PspB; pfam06667 269796004043 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 269796004044 phage shock protein A; Region: phageshock_pspA; TIGR02977 269796004045 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 269796004046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796004047 Walker A motif; other site 269796004048 ATP binding site [chemical binding]; other site 269796004049 Walker B motif; other site 269796004050 arginine finger; other site 269796004051 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 269796004052 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 269796004053 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 269796004054 active site 269796004055 DNA binding site [nucleotide binding] 269796004056 Int/Topo IB signature motif; other site 269796004057 Protein of unknown function, DUF484; Region: DUF484; cl17449 269796004058 primosome assembly protein PriA; Validated; Region: PRK05580 269796004059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269796004060 ATP binding site [chemical binding]; other site 269796004061 putative Mg++ binding site [ion binding]; other site 269796004062 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 269796004063 helicase superfamily c-terminal domain; Region: HELICc; smart00490 269796004064 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 269796004065 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 269796004066 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 269796004067 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 269796004068 beta subunit interaction interface [polypeptide binding]; other site 269796004069 Walker A motif; other site 269796004070 ATP binding site [chemical binding]; other site 269796004071 Walker B motif; other site 269796004072 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 269796004073 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 269796004074 core domain interface [polypeptide binding]; other site 269796004075 delta subunit interface [polypeptide binding]; other site 269796004076 epsilon subunit interface [polypeptide binding]; other site 269796004077 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 269796004078 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 269796004079 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 269796004080 alpha subunit interaction interface [polypeptide binding]; other site 269796004081 Walker A motif; other site 269796004082 ATP binding site [chemical binding]; other site 269796004083 Walker B motif; other site 269796004084 inhibitor binding site; inhibition site 269796004085 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 269796004086 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK01474 269796004087 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 269796004088 gamma subunit interface [polypeptide binding]; other site 269796004089 epsilon subunit interface [polypeptide binding]; other site 269796004090 LBP interface [polypeptide binding]; other site 269796004091 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 269796004092 dinuclear metal binding motif [ion binding]; other site 269796004093 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 269796004094 SdiA-regulated; Region: SdiA-regulated; cl19046 269796004095 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 269796004096 putative active site [active] 269796004097 Ap4A binding site [chemical binding]; other site 269796004098 nudix motif; other site 269796004099 putative metal binding site [ion binding]; other site 269796004100 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 269796004101 NodB motif; other site 269796004102 putative active site [active] 269796004103 putative catalytic site [active] 269796004104 Zn binding site [ion binding]; other site 269796004105 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 269796004106 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 269796004107 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 269796004108 protein binding site [polypeptide binding]; other site 269796004109 Catalytic dyad [active] 269796004110 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 269796004111 Peptidase family M23; Region: Peptidase_M23; pfam01551 269796004112 phosphoglyceromutase; Provisional; Region: PRK05434 269796004113 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 269796004114 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 269796004115 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 269796004116 active site 269796004117 (T/H)XGH motif; other site 269796004118 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 269796004119 putative catalytic cysteine [active] 269796004120 gamma-glutamyl kinase; Provisional; Region: PRK05429 269796004121 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 269796004122 nucleotide binding site [chemical binding]; other site 269796004123 homotetrameric interface [polypeptide binding]; other site 269796004124 putative phosphate binding site [ion binding]; other site 269796004125 putative allosteric binding site; other site 269796004126 PUA domain; Region: PUA; pfam01472 269796004127 GTPase CgtA; Reviewed; Region: obgE; PRK12299 269796004128 GTP1/OBG; Region: GTP1_OBG; pfam01018 269796004129 Obg GTPase; Region: Obg; cd01898 269796004130 G1 box; other site 269796004131 GTP/Mg2+ binding site [chemical binding]; other site 269796004132 Switch I region; other site 269796004133 G2 box; other site 269796004134 G3 box; other site 269796004135 Switch II region; other site 269796004136 G4 box; other site 269796004137 G5 box; other site 269796004138 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 269796004139 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 269796004140 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 269796004141 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 269796004142 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 269796004143 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269796004144 ligand binding site [chemical binding]; other site 269796004145 flexible hinge region; other site 269796004146 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 269796004147 putative switch regulator; other site 269796004148 non-specific DNA interactions [nucleotide binding]; other site 269796004149 DNA binding site [nucleotide binding] 269796004150 sequence specific DNA binding site [nucleotide binding]; other site 269796004151 putative cAMP binding site [chemical binding]; other site 269796004152 HipA N-terminal domain; Region: Couple_hipA; cl11853 269796004153 HipA-like N-terminal domain; Region: HipA_N; pfam07805 269796004154 HipA-like C-terminal domain; Region: HipA_C; pfam07804 269796004155 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796004156 non-specific DNA binding site [nucleotide binding]; other site 269796004157 salt bridge; other site 269796004158 sequence-specific DNA binding site [nucleotide binding]; other site 269796004159 AAA domain; Region: AAA_17; cl19128 269796004160 AAA domain; Region: AAA_33; pfam13671 269796004161 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 269796004162 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 269796004163 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 269796004164 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; cl19416 269796004165 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 269796004166 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 269796004167 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 269796004168 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 269796004169 inhibitor-cofactor binding pocket; inhibition site 269796004170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796004171 catalytic residue [active] 269796004172 Transcriptional regulators [Transcription]; Region: GntR; COG1802 269796004173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 269796004174 DNA-binding site [nucleotide binding]; DNA binding site 269796004175 FCD domain; Region: FCD; pfam07729 269796004176 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 269796004177 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 269796004178 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 269796004179 Walker A/P-loop; other site 269796004180 ATP binding site [chemical binding]; other site 269796004181 Q-loop/lid; other site 269796004182 ABC transporter signature motif; other site 269796004183 Walker B; other site 269796004184 D-loop; other site 269796004185 H-loop/switch region; other site 269796004186 TOBE domain; Region: TOBE_2; pfam08402 269796004187 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 269796004188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796004189 dimer interface [polypeptide binding]; other site 269796004190 conserved gate region; other site 269796004191 putative PBP binding loops; other site 269796004192 ABC-ATPase subunit interface; other site 269796004193 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 269796004194 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 269796004195 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 269796004196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796004197 dimer interface [polypeptide binding]; other site 269796004198 conserved gate region; other site 269796004199 putative PBP binding loops; other site 269796004200 ABC-ATPase subunit interface; other site 269796004201 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 269796004202 classical (c) SDRs; Region: SDR_c; cd05233 269796004203 NAD(P) binding site [chemical binding]; other site 269796004204 active site 269796004205 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 269796004206 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 269796004207 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 269796004208 BtpA family; Region: BtpA; cl00440 269796004209 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 269796004210 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 269796004211 N- and C-terminal domain interface [polypeptide binding]; other site 269796004212 putative active site [active] 269796004213 MgATP binding site [chemical binding]; other site 269796004214 catalytic site [active] 269796004215 metal binding site [ion binding]; metal-binding site 269796004216 putative xylulose binding site [chemical binding]; other site 269796004217 putative homodimer interface [polypeptide binding]; other site 269796004218 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 269796004219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269796004220 active site 269796004221 motif I; other site 269796004222 motif II; other site 269796004223 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 269796004224 AAA domain; Region: AAA_23; pfam13476 269796004225 AAA domain; Region: AAA_27; pfam13514 269796004226 Walker A/P-loop; other site 269796004227 ATP binding site [chemical binding]; other site 269796004228 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 269796004229 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 269796004230 active site 269796004231 metal binding site [ion binding]; metal-binding site 269796004232 DNA binding site [nucleotide binding] 269796004233 PAS domain S-box; Region: sensory_box; TIGR00229 269796004234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796004235 putative active site [active] 269796004236 heme pocket [chemical binding]; other site 269796004237 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796004238 metal binding site [ion binding]; metal-binding site 269796004239 active site 269796004240 I-site; other site 269796004241 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 269796004242 Putative lysophospholipase; Region: Hydrolase_4; cl19140 269796004243 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 269796004244 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796004245 FeS/SAM binding site; other site 269796004246 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 269796004247 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 269796004248 ATP cone domain; Region: ATP-cone; pfam03477 269796004249 Class III ribonucleotide reductase; Region: RNR_III; cd01675 269796004250 effector binding site; other site 269796004251 active site 269796004252 Zn binding site [ion binding]; other site 269796004253 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 269796004254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796004255 dimer interface [polypeptide binding]; other site 269796004256 phosphorylation site [posttranslational modification] 269796004257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796004258 ATP binding site [chemical binding]; other site 269796004259 Mg2+ binding site [ion binding]; other site 269796004260 G-X-G motif; other site 269796004261 response regulator FixJ; Provisional; Region: fixJ; PRK09390 269796004262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796004263 active site 269796004264 phosphorylation site [posttranslational modification] 269796004265 intermolecular recognition site; other site 269796004266 dimerization interface [polypeptide binding]; other site 269796004267 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 269796004268 putative binding surface; other site 269796004269 active site 269796004270 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 269796004271 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 269796004272 active site 269796004273 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 269796004274 Ligand Binding Site [chemical binding]; other site 269796004275 Molecular Tunnel; other site 269796004276 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 269796004277 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 269796004278 active site 269796004279 metal-binding site [ion binding] 269796004280 nucleotide-binding site [chemical binding]; other site 269796004281 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 269796004282 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 269796004283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796004284 active site 269796004285 phosphorylation site [posttranslational modification] 269796004286 intermolecular recognition site; other site 269796004287 dimerization interface [polypeptide binding]; other site 269796004288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269796004289 DNA binding site [nucleotide binding] 269796004290 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 269796004291 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 269796004292 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 269796004293 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 269796004294 AAA ATPase domain; Region: AAA_16; pfam13191 269796004295 FOG: WD40 repeat [General function prediction only]; Region: COG2319 269796004296 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 269796004297 structural tetrad; other site 269796004298 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 269796004299 structural tetrad; other site 269796004300 FOG: WD40 repeat [General function prediction only]; Region: COG2319 269796004301 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 269796004302 structural tetrad; other site 269796004303 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 269796004304 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 269796004305 molybdopterin cofactor binding site [chemical binding]; other site 269796004306 substrate binding site [chemical binding]; other site 269796004307 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 269796004308 molybdopterin cofactor binding site; other site 269796004309 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 269796004310 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796004311 FeS/SAM binding site; other site 269796004312 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 269796004313 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 269796004314 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl19058 269796004315 dimer interface [polypeptide binding]; other site 269796004316 active site 269796004317 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 269796004318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796004319 Walker A/P-loop; other site 269796004320 ATP binding site [chemical binding]; other site 269796004321 Q-loop/lid; other site 269796004322 ABC transporter signature motif; other site 269796004323 Walker B; other site 269796004324 D-loop; other site 269796004325 H-loop/switch region; other site 269796004326 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 269796004327 FtsX-like permease family; Region: FtsX; pfam02687 269796004328 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 269796004329 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796004330 dimerization interface [polypeptide binding]; other site 269796004331 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796004332 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796004333 dimer interface [polypeptide binding]; other site 269796004334 putative CheW interface [polypeptide binding]; other site 269796004335 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 269796004336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 269796004337 DNA-binding site [nucleotide binding]; DNA binding site 269796004338 UTRA domain; Region: UTRA; pfam07702 269796004339 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 269796004340 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 269796004341 substrate binding pocket [chemical binding]; other site 269796004342 membrane-bound complex binding site; other site 269796004343 hinge residues; other site 269796004344 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 269796004345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796004346 dimer interface [polypeptide binding]; other site 269796004347 conserved gate region; other site 269796004348 putative PBP binding loops; other site 269796004349 ABC-ATPase subunit interface; other site 269796004350 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 269796004351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796004352 dimer interface [polypeptide binding]; other site 269796004353 conserved gate region; other site 269796004354 putative PBP binding loops; other site 269796004355 ABC-ATPase subunit interface; other site 269796004356 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 269796004357 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 269796004358 Walker A/P-loop; other site 269796004359 ATP binding site [chemical binding]; other site 269796004360 Q-loop/lid; other site 269796004361 ABC transporter signature motif; other site 269796004362 Walker B; other site 269796004363 D-loop; other site 269796004364 H-loop/switch region; other site 269796004365 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 269796004366 FAD binding domain; Region: FAD_binding_4; pfam01565 269796004367 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 269796004368 N-formylglutamate amidohydrolase; Region: FGase; cl01522 269796004369 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 269796004370 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 269796004371 active sites [active] 269796004372 tetramer interface [polypeptide binding]; other site 269796004373 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 269796004374 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 269796004375 active site 269796004376 imidazolonepropionase; Validated; Region: PRK09356 269796004377 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 269796004378 active site 269796004379 urocanate hydratase; Provisional; Region: PRK05414 269796004380 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 269796004381 short chain dehydrogenase; Provisional; Region: PRK08278 269796004382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269796004383 NAD(P) binding site [chemical binding]; other site 269796004384 active site 269796004385 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 269796004386 active site 269796004387 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 269796004388 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 269796004389 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 269796004390 active site 269796004391 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 269796004392 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 269796004393 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 269796004394 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 269796004395 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269796004396 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 269796004397 substrate binding site [chemical binding]; other site 269796004398 oxyanion hole (OAH) forming residues; other site 269796004399 trimer interface [polypeptide binding]; other site 269796004400 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 269796004401 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 269796004402 dimer interface [polypeptide binding]; other site 269796004403 active site 269796004404 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 269796004405 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 269796004406 DNA binding residues [nucleotide binding] 269796004407 putative dimer interface [polypeptide binding]; other site 269796004408 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 269796004409 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 269796004410 acyl-activating enzyme (AAE) consensus motif; other site 269796004411 putative AMP binding site [chemical binding]; other site 269796004412 putative active site [active] 269796004413 putative CoA binding site [chemical binding]; other site 269796004414 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 269796004415 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 269796004416 SCP-2 sterol transfer family; Region: SCP2; pfam02036 269796004417 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 269796004418 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 269796004419 dimer interface [polypeptide binding]; other site 269796004420 acyl-activating enzyme (AAE) consensus motif; other site 269796004421 putative active site [active] 269796004422 AMP binding site [chemical binding]; other site 269796004423 putative CoA binding site [chemical binding]; other site 269796004424 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 269796004425 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796004426 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 269796004427 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 269796004428 hexamer interface [polypeptide binding]; other site 269796004429 RNA binding site [nucleotide binding]; other site 269796004430 Histidine-zinc binding site [chemical binding]; other site 269796004431 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 269796004432 Na+-transporting malonate decarboxylase, carboxybiotin decarboxylase subunit; Region: malonate_biotin; TIGR03136 269796004433 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 269796004434 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 269796004435 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 269796004436 Coenzyme A transferase; Region: CoA_trans; cl17247 269796004437 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 269796004438 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 269796004439 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 269796004440 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 269796004441 malonate decarboxylase holo-[acyl-carrier-protein] synthase; Region: malonate_mdcG; TIGR03135 269796004442 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 269796004443 carboxyltransferase (CT) interaction site; other site 269796004444 biotinylation site [posttranslational modification]; other site 269796004445 Malonate transporter MadL subunit; Region: MadL; cl04273 269796004446 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 269796004447 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 269796004448 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 269796004449 Walker A/P-loop; other site 269796004450 ATP binding site [chemical binding]; other site 269796004451 Q-loop/lid; other site 269796004452 ABC transporter signature motif; other site 269796004453 Walker B; other site 269796004454 D-loop; other site 269796004455 H-loop/switch region; other site 269796004456 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 269796004457 BioY family; Region: BioY; pfam02632 269796004458 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 269796004459 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 269796004460 TM-ABC transporter signature motif; other site 269796004461 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 269796004462 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 269796004463 ligand binding site [chemical binding]; other site 269796004464 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 269796004465 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 269796004466 Walker A/P-loop; other site 269796004467 ATP binding site [chemical binding]; other site 269796004468 Q-loop/lid; other site 269796004469 ABC transporter signature motif; other site 269796004470 Walker B; other site 269796004471 D-loop; other site 269796004472 H-loop/switch region; other site 269796004473 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 269796004474 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 269796004475 TM-ABC transporter signature motif; other site 269796004476 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 269796004477 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 269796004478 DNA binding residues [nucleotide binding] 269796004479 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 269796004480 Dak1 domain; Region: Dak1; cl10557 269796004481 DAK2 domain; Region: Dak2; pfam02734 269796004482 Uncharacterized conserved protein [Function unknown]; Region: COG5476 269796004483 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 269796004484 MlrC C-terminus; Region: MlrC_C; pfam07171 269796004485 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 269796004486 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 269796004487 Bacterial transcriptional regulator; Region: IclR; pfam01614 269796004488 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 269796004489 putative active site; other site 269796004490 catalytic residue [active] 269796004491 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 269796004492 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 269796004493 N- and C-terminal domain interface [polypeptide binding]; other site 269796004494 active site 269796004495 MgATP binding site [chemical binding]; other site 269796004496 catalytic site [active] 269796004497 metal binding site [ion binding]; metal-binding site 269796004498 carbohydrate binding site [chemical binding]; other site 269796004499 putative homodimer interface [polypeptide binding]; other site 269796004500 Transcriptional regulators [Transcription]; Region: FadR; COG2186 269796004501 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 269796004502 DNA-binding site [nucleotide binding]; DNA binding site 269796004503 FCD domain; Region: FCD; pfam07729 269796004504 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 269796004505 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 269796004506 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 269796004507 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 269796004508 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 269796004509 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 269796004510 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 269796004511 Domain of unknown function (DUF892); Region: DUF892; pfam05974 269796004512 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 269796004513 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 269796004514 heme binding pocket [chemical binding]; other site 269796004515 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 269796004516 domain interactions; other site 269796004517 transaldolase-like protein; Provisional; Region: PTZ00411 269796004518 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 269796004519 active site 269796004520 dimer interface [polypeptide binding]; other site 269796004521 catalytic residue [active] 269796004522 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 269796004523 substrate binding site [chemical binding]; other site 269796004524 dimer interface [polypeptide binding]; other site 269796004525 catalytic triad [active] 269796004526 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 269796004527 DAK2 domain; Region: Dak2; cl03685 269796004528 Dak1 domain; Region: Dak1; cl10557 269796004529 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 269796004530 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 269796004531 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 269796004532 TM-ABC transporter signature motif; other site 269796004533 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 269796004534 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 269796004535 Walker A/P-loop; other site 269796004536 ATP binding site [chemical binding]; other site 269796004537 Q-loop/lid; other site 269796004538 ABC transporter signature motif; other site 269796004539 Walker B; other site 269796004540 D-loop; other site 269796004541 H-loop/switch region; other site 269796004542 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 269796004543 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 269796004544 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 269796004545 ligand binding site [chemical binding]; other site 269796004546 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 269796004547 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 269796004548 DNA binding residues [nucleotide binding] 269796004549 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 269796004550 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 269796004551 tetramer interface [polypeptide binding]; other site 269796004552 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 269796004553 active site 269796004554 Caspase domain; Region: Peptidase_C14; pfam00656 269796004555 Caspase domain; Region: Peptidase_C14; pfam00656 269796004556 phosphate acetyltransferase; Reviewed; Region: PRK05632 269796004557 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 269796004558 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 269796004559 putative acyltransferase; Provisional; Region: PRK05790 269796004560 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 269796004561 dimer interface [polypeptide binding]; other site 269796004562 active site 269796004563 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 269796004564 Coenzyme A transferase; Region: CoA_trans; cl17247 269796004565 Coenzyme A transferase; Region: CoA_trans; cl17247 269796004566 sensory histidine kinase AtoS; Provisional; Region: PRK11360 269796004567 HAMP domain; Region: HAMP; pfam00672 269796004568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796004569 putative active site [active] 269796004570 heme pocket [chemical binding]; other site 269796004571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796004572 dimer interface [polypeptide binding]; other site 269796004573 phosphorylation site [posttranslational modification] 269796004574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796004575 ATP binding site [chemical binding]; other site 269796004576 Mg2+ binding site [ion binding]; other site 269796004577 G-X-G motif; other site 269796004578 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 269796004579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796004580 active site 269796004581 phosphorylation site [posttranslational modification] 269796004582 intermolecular recognition site; other site 269796004583 dimerization interface [polypeptide binding]; other site 269796004584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796004585 Walker A motif; other site 269796004586 ATP binding site [chemical binding]; other site 269796004587 Walker B motif; other site 269796004588 arginine finger; other site 269796004589 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269796004590 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 269796004591 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 269796004592 ATP binding site [chemical binding]; other site 269796004593 putative Mg++ binding site [ion binding]; other site 269796004594 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269796004595 nucleotide binding region [chemical binding]; other site 269796004596 ATP-binding site [chemical binding]; other site 269796004597 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 269796004598 RNA binding site [nucleotide binding]; other site 269796004599 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 269796004600 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 269796004601 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269796004602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796004603 Walker A motif; other site 269796004604 ATP binding site [chemical binding]; other site 269796004605 Walker B motif; other site 269796004606 arginine finger; other site 269796004607 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269796004608 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 269796004609 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 269796004610 putative active site pocket [active] 269796004611 dimerization interface [polypeptide binding]; other site 269796004612 putative catalytic residue [active] 269796004613 Fe-only nitrogenase accessory protein AnfO; Region: anfO_nitrog; TIGR02940 269796004614 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 269796004615 Nitrogenase_VFe_beta -like: Nitrogenase VFe protein, beta subunit like. This group contains proteins similar to the beta subunits of the VFe protein of the vanadium-dependent (V-) nitrogenase. Nitrogenase catalyzes the ATP-dependent reduction of...; Region: Nitrogenase_VFe_beta_like; cd01973 269796004616 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; pfam03139 269796004617 nitrogenase iron-iron protein, alpha chain; Region: ANFD; TIGR01861 269796004618 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 269796004619 nitrogenase iron protein; Region: nifH; TIGR01287 269796004620 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 269796004621 Nucleotide-binding sites [chemical binding]; other site 269796004622 Walker A motif; other site 269796004623 Switch I region of nucleotide binding site; other site 269796004624 Fe4S4 binding sites [ion binding]; other site 269796004625 Switch II region of nucleotide binding site; other site 269796004626 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 269796004627 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 269796004628 anti sigma factor interaction site; other site 269796004629 regulatory phosphorylation site [posttranslational modification]; other site 269796004630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796004631 active site 269796004632 phosphorylation site [posttranslational modification] 269796004633 intermolecular recognition site; other site 269796004634 dimerization interface [polypeptide binding]; other site 269796004635 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 269796004636 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 269796004637 putative binding surface; other site 269796004638 active site 269796004639 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 269796004640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796004641 ATP binding site [chemical binding]; other site 269796004642 Mg2+ binding site [ion binding]; other site 269796004643 G-X-G motif; other site 269796004644 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 269796004645 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 269796004646 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 269796004647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796004648 dimerization interface [polypeptide binding]; other site 269796004649 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796004650 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796004651 dimer interface [polypeptide binding]; other site 269796004652 putative CheW interface [polypeptide binding]; other site 269796004653 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 269796004654 putative CheA interaction surface; other site 269796004655 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 269796004656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796004657 dimerization interface [polypeptide binding]; other site 269796004658 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 269796004659 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796004660 dimer interface [polypeptide binding]; other site 269796004661 putative CheW interface [polypeptide binding]; other site 269796004662 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 269796004663 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 269796004664 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796004665 dimerization interface [polypeptide binding]; other site 269796004666 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796004667 dimer interface [polypeptide binding]; other site 269796004668 putative CheW interface [polypeptide binding]; other site 269796004669 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 269796004670 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 269796004671 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 269796004672 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 269796004673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796004674 active site 269796004675 phosphorylation site [posttranslational modification] 269796004676 intermolecular recognition site; other site 269796004677 dimerization interface [polypeptide binding]; other site 269796004678 CheB methylesterase; Region: CheB_methylest; pfam01339 269796004679 CheD chemotactic sensory transduction; Region: CheD; cl00810 269796004680 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 269796004681 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796004682 dimerization interface [polypeptide binding]; other site 269796004683 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796004684 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796004685 dimer interface [polypeptide binding]; other site 269796004686 putative CheW interface [polypeptide binding]; other site 269796004687 L-lactate permease; Region: Lactate_perm; cl00701 269796004688 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 269796004689 FAD binding domain; Region: FAD_binding_4; pfam01565 269796004690 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 269796004691 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 269796004692 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 269796004693 Cysteine-rich domain; Region: CCG; pfam02754 269796004694 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 269796004695 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 269796004696 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 269796004697 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 269796004698 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 269796004699 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 269796004700 Cysteine-rich domain; Region: CCG; pfam02754 269796004701 Cysteine-rich domain; Region: CCG; pfam02754 269796004702 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 269796004703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 269796004704 DNA-binding site [nucleotide binding]; DNA binding site 269796004705 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 269796004706 PIN domain; Region: PIN_3; pfam13470 269796004707 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 269796004708 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 269796004709 catalytic residue [active] 269796004710 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 269796004711 catalytic residues [active] 269796004712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796004713 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269796004714 peroxiredoxin; Region: AhpC; TIGR03137 269796004715 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 269796004716 dimer interface [polypeptide binding]; other site 269796004717 decamer (pentamer of dimers) interface [polypeptide binding]; other site 269796004718 catalytic triad [active] 269796004719 peroxidatic and resolving cysteines [active] 269796004720 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 269796004721 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269796004722 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269796004723 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 269796004724 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269796004725 NADH dehydrogenase; Region: NADHdh; cl00469 269796004726 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 269796004727 hydrogenase 4 subunit H; Validated; Region: PRK08222 269796004728 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 269796004729 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 269796004730 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 269796004731 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 269796004732 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 269796004733 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 269796004734 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 269796004735 ACS interaction site; other site 269796004736 CODH interaction site; other site 269796004737 cubane metal cluster (B-cluster) [ion binding]; other site 269796004738 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 269796004739 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 269796004740 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 269796004741 P-loop; other site 269796004742 Predicted RNA-binding protein; Region: RNA_bind_2; cl00662 269796004743 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269796004744 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 269796004745 ligand binding site [chemical binding]; other site 269796004746 flexible hinge region; other site 269796004747 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 269796004748 putative switch regulator; other site 269796004749 non-specific DNA interactions [nucleotide binding]; other site 269796004750 DNA binding site [nucleotide binding] 269796004751 sequence specific DNA binding site [nucleotide binding]; other site 269796004752 putative cAMP binding site [chemical binding]; other site 269796004753 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 269796004754 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 269796004755 dimerization interface [polypeptide binding]; other site 269796004756 active site 269796004757 L-aspartate oxidase; Provisional; Region: PRK07512 269796004758 L-aspartate oxidase; Provisional; Region: PRK06175 269796004759 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 269796004760 quinolinate synthetase; Provisional; Region: PRK09375 269796004761 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269796004762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796004763 active site 269796004764 phosphorylation site [posttranslational modification] 269796004765 intermolecular recognition site; other site 269796004766 dimerization interface [polypeptide binding]; other site 269796004767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796004768 Walker A motif; other site 269796004769 ATP binding site [chemical binding]; other site 269796004770 Walker B motif; other site 269796004771 arginine finger; other site 269796004772 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269796004773 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 269796004774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796004775 dimer interface [polypeptide binding]; other site 269796004776 phosphorylation site [posttranslational modification] 269796004777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796004778 ATP binding site [chemical binding]; other site 269796004779 Mg2+ binding site [ion binding]; other site 269796004780 G-X-G motif; other site 269796004781 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 269796004782 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 269796004783 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269796004784 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269796004785 DNA binding residues [nucleotide binding] 269796004786 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 269796004787 FecR protein; Region: FecR; pfam04773 269796004788 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 269796004789 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269796004790 N-terminal plug; other site 269796004791 ligand-binding site [chemical binding]; other site 269796004792 Transcriptional regulators [Transcription]; Region: MarR; COG1846 269796004793 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 269796004794 Methyltransferase domain; Region: Methyltransf_24; pfam13578 269796004795 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 269796004796 Class I ribonucleotide reductase; Region: RNR_I; cd01679 269796004797 active site 269796004798 dimer interface [polypeptide binding]; other site 269796004799 catalytic residues [active] 269796004800 effector binding site; other site 269796004801 R2 peptide binding site; other site 269796004802 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 269796004803 dimer interface [polypeptide binding]; other site 269796004804 putative radical transfer pathway; other site 269796004805 diiron center [ion binding]; other site 269796004806 tyrosyl radical; other site 269796004807 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 269796004808 dimerization interface [polypeptide binding]; other site 269796004809 metal binding site [ion binding]; metal-binding site 269796004810 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 269796004811 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 269796004812 P loop; other site 269796004813 Nucleotide binding site [chemical binding]; other site 269796004814 DTAP/Switch II; other site 269796004815 Switch I; other site 269796004816 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 269796004817 P loop; other site 269796004818 Nucleotide binding site [chemical binding]; other site 269796004819 DTAP/Switch II; other site 269796004820 Switch I; other site 269796004821 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 269796004822 arsenical-resistance protein; Region: acr3; TIGR00832 269796004823 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269796004824 dimerization interface [polypeptide binding]; other site 269796004825 putative DNA binding site [nucleotide binding]; other site 269796004826 putative Zn2+ binding site [ion binding]; other site 269796004827 Low molecular weight phosphatase family; Region: LMWPc; cd00115 269796004828 active site 269796004829 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 269796004830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 269796004831 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 269796004832 Phage Tail Collar Domain; Region: Collar; pfam07484 269796004833 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 269796004834 Phage Tail Collar Domain; Region: Collar; pfam07484 269796004835 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 269796004836 Phage Tail Collar Domain; Region: Collar; pfam07484 269796004837 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 269796004838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796004839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796004840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796004841 S-adenosylmethionine binding site [chemical binding]; other site 269796004842 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 269796004843 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 269796004844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796004845 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796004846 putative substrate translocation pore; other site 269796004847 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 269796004848 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 269796004849 Ligand Binding Site [chemical binding]; other site 269796004850 Molecular Tunnel; other site 269796004851 2-isopropylmalate synthase; Validated; Region: PRK03739 269796004852 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 269796004853 active site 269796004854 catalytic residues [active] 269796004855 metal binding site [ion binding]; metal-binding site 269796004856 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 269796004857 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 269796004858 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 269796004859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796004860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796004861 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 269796004862 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 269796004863 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 269796004864 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796004865 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796004866 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 269796004867 putative dimerization interface [polypeptide binding]; other site 269796004868 Acetokinase family; Region: Acetate_kinase; cl17229 269796004869 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 269796004870 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 269796004871 dimer interaction site [polypeptide binding]; other site 269796004872 substrate-binding tunnel; other site 269796004873 active site 269796004874 catalytic site [active] 269796004875 substrate binding site [chemical binding]; other site 269796004876 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 269796004877 putative acyltransferase; Provisional; Region: PRK05790 269796004878 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 269796004879 dimer interface [polypeptide binding]; other site 269796004880 active site 269796004881 Coenzyme A transferase; Region: CoA_trans; cl17247 269796004882 Coenzyme A transferase; Region: CoA_trans; cl17247 269796004883 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 269796004884 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 269796004885 Citrate transporter; Region: CitMHS; pfam03600 269796004886 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 269796004887 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 269796004888 PhnA protein; Region: PhnA; pfam03831 269796004889 Methyltransferase domain; Region: Methyltransf_24; pfam13578 269796004890 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 269796004891 active site 269796004892 metal-binding site [ion binding] 269796004893 AAA domain; Region: AAA_17; pfam13207 269796004894 nucleotide-binding site [chemical binding]; other site 269796004895 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 269796004896 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 269796004897 CoA binding domain; Region: CoA_binding; cl17356 269796004898 Bacterial sugar transferase; Region: Bac_transf; pfam02397 269796004899 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 269796004900 active site 269796004901 dimer interface [polypeptide binding]; other site 269796004902 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 269796004903 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 269796004904 Ligand Binding Site [chemical binding]; other site 269796004905 Molecular Tunnel; other site 269796004906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796004907 S-adenosylmethionine binding site [chemical binding]; other site 269796004908 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 269796004909 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 269796004910 Right handed beta helix region; Region: Beta_helix; pfam13229 269796004911 Right handed beta helix region; Region: Beta_helix; pfam13229 269796004912 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 269796004913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269796004914 NAD(P) binding site [chemical binding]; other site 269796004915 active site 269796004916 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 269796004917 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 269796004918 SLBB domain; Region: SLBB; pfam10531 269796004919 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 269796004920 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 269796004921 active site 269796004922 metal binding site [ion binding]; metal-binding site 269796004923 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 269796004924 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 269796004925 Chain length determinant protein; Region: Wzz; pfam02706 269796004926 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 269796004927 AAA domain; Region: AAA_31; pfam13614 269796004928 O-Antigen ligase; Region: Wzy_C; pfam04932 269796004929 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 269796004930 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 269796004931 active site 269796004932 homodimer interface [polypeptide binding]; other site 269796004933 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 269796004934 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796004935 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796004936 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 269796004937 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269796004938 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 269796004939 Walker A/P-loop; other site 269796004940 ATP binding site [chemical binding]; other site 269796004941 Q-loop/lid; other site 269796004942 ABC transporter signature motif; other site 269796004943 Walker B; other site 269796004944 D-loop; other site 269796004945 H-loop/switch region; other site 269796004946 DNA starvation/stationary phase protection protein Dps; Provisional; Region: PRK09448 269796004947 Ferritin-like domain; Region: Ferritin; pfam00210 269796004948 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 269796004949 CheB methylesterase; Region: CheB_methylest; pfam01339 269796004950 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 269796004951 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 269796004952 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 269796004953 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 269796004954 PAS domain; Region: PAS_10; pfam13596 269796004955 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796004956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796004957 ATP binding site [chemical binding]; other site 269796004958 Mg2+ binding site [ion binding]; other site 269796004959 G-X-G motif; other site 269796004960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796004961 active site 269796004962 phosphorylation site [posttranslational modification] 269796004963 intermolecular recognition site; other site 269796004964 dimerization interface [polypeptide binding]; other site 269796004965 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 269796004966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796004967 active site 269796004968 phosphorylation site [posttranslational modification] 269796004969 intermolecular recognition site; other site 269796004970 dimerization interface [polypeptide binding]; other site 269796004971 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 269796004972 DNA binding residues [nucleotide binding] 269796004973 dimerization interface [polypeptide binding]; other site 269796004974 BON domain; Region: BON; pfam04972 269796004975 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 269796004976 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 269796004977 putative NAD(P) binding site [chemical binding]; other site 269796004978 putative substrate binding site [chemical binding]; other site 269796004979 catalytic Zn binding site [ion binding]; other site 269796004980 structural Zn binding site [ion binding]; other site 269796004981 dimer interface [polypeptide binding]; other site 269796004982 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 269796004983 putative active site [active] 269796004984 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 269796004985 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 269796004986 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 269796004987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269796004988 NAD(P) binding site [chemical binding]; other site 269796004989 active site 269796004990 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 269796004991 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796004992 PRC-barrel domain; Region: PRC; pfam05239 269796004993 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269796004994 active site 269796004995 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 269796004996 metal binding triad [ion binding]; metal-binding site 269796004997 Protein of unknown function DUF86; Region: DUF86; cl01031 269796004998 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269796004999 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 269796005000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 269796005001 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 269796005002 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 269796005003 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 269796005004 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 269796005005 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 269796005006 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 269796005007 DNA-binding site [nucleotide binding]; DNA binding site 269796005008 RNA-binding motif; other site 269796005009 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 269796005010 Hemerythrin; Region: Hemerythrin; cd12107 269796005011 Fe binding site [ion binding]; other site 269796005012 Hemerythrin; Region: Hemerythrin; cd12107 269796005013 Fe binding site [ion binding]; other site 269796005014 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 269796005015 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 269796005016 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 269796005017 dimer interface [polypeptide binding]; other site 269796005018 ADP-ribose binding site [chemical binding]; other site 269796005019 active site 269796005020 nudix motif; other site 269796005021 metal binding site [ion binding]; metal-binding site 269796005022 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 269796005023 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 269796005024 P-loop; other site 269796005025 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796005026 Magnesium ion binding site [ion binding]; other site 269796005027 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 269796005028 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269796005029 ABC transporter; Region: ABC_tran_2; pfam12848 269796005030 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269796005031 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 269796005032 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269796005033 dimerization interface [polypeptide binding]; other site 269796005034 putative DNA binding site [nucleotide binding]; other site 269796005035 putative Zn2+ binding site [ion binding]; other site 269796005036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796005037 Methyltransferase domain; Region: Methyltransf_31; pfam13847 269796005038 S-adenosylmethionine binding site [chemical binding]; other site 269796005039 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 269796005040 FAD binding site [chemical binding]; other site 269796005041 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 269796005042 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 269796005043 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 269796005044 substrate binding pocket [chemical binding]; other site 269796005045 dimer interface [polypeptide binding]; other site 269796005046 inhibitor binding site; inhibition site 269796005047 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 269796005048 B12 binding site [chemical binding]; other site 269796005049 cobalt ligand [ion binding]; other site 269796005050 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 269796005051 PET122; Region: PET122; pfam05476 269796005052 Tetratricopeptide repeat; Region: TPR_12; pfam13424 269796005053 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269796005054 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 269796005055 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269796005056 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269796005057 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 269796005058 Cl- selectivity filter; other site 269796005059 Cl- binding residues [ion binding]; other site 269796005060 pore gating glutamate residue; other site 269796005061 dimer interface [polypeptide binding]; other site 269796005062 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 269796005063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796005064 non-specific DNA binding site [nucleotide binding]; other site 269796005065 salt bridge; other site 269796005066 sequence-specific DNA binding site [nucleotide binding]; other site 269796005067 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 269796005068 Part of AAA domain; Region: AAA_19; pfam13245 269796005069 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 269796005070 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 269796005071 TOBE domain; Region: TOBE; cl01440 269796005072 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796005073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796005074 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 269796005075 dimerization interface [polypeptide binding]; other site 269796005076 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 269796005077 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 269796005078 inhibitor-cofactor binding pocket; inhibition site 269796005079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796005080 catalytic residue [active] 269796005081 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 269796005082 tetrameric interface [polypeptide binding]; other site 269796005083 NAD binding site [chemical binding]; other site 269796005084 catalytic residues [active] 269796005085 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 269796005086 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 269796005087 dimerization interface [polypeptide binding]; other site 269796005088 active site 269796005089 PAS domain S-box; Region: sensory_box; TIGR00229 269796005090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796005091 putative active site [active] 269796005092 heme pocket [chemical binding]; other site 269796005093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796005094 PAS domain; Region: PAS_9; pfam13426 269796005095 putative active site [active] 269796005096 heme pocket [chemical binding]; other site 269796005097 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796005098 metal binding site [ion binding]; metal-binding site 269796005099 active site 269796005100 I-site; other site 269796005101 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796005102 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796005103 metal binding site [ion binding]; metal-binding site 269796005104 active site 269796005105 I-site; other site 269796005106 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 269796005107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796005108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796005109 Uncharacterized conserved protein [Function unknown]; Region: COG0062 269796005110 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 269796005111 putative substrate binding site [chemical binding]; other site 269796005112 putative ATP binding site [chemical binding]; other site 269796005113 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 269796005114 trigger factor; Provisional; Region: tig; PRK01490 269796005115 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 269796005116 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 269796005117 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 269796005118 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 269796005119 oligomer interface [polypeptide binding]; other site 269796005120 active site residues [active] 269796005121 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 269796005122 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 269796005123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796005124 Walker A motif; other site 269796005125 ATP binding site [chemical binding]; other site 269796005126 Walker B motif; other site 269796005127 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 269796005128 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 269796005129 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 269796005130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796005131 Walker A motif; other site 269796005132 ATP binding site [chemical binding]; other site 269796005133 Walker B motif; other site 269796005134 arginine finger; other site 269796005135 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 269796005136 histone-like DNA-binding protein HU; Region: HU; cd13831 269796005137 dimer interface [polypeptide binding]; other site 269796005138 DNA binding site [nucleotide binding] 269796005139 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796005140 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796005141 dimer interface [polypeptide binding]; other site 269796005142 putative CheW interface [polypeptide binding]; other site 269796005143 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 269796005144 NADH dehydrogenase subunit B; Validated; Region: PRK06411 269796005145 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 269796005146 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 269796005147 NADH dehydrogenase subunit D; Validated; Region: PRK06075 269796005148 Protein of unknown function, DUF393; Region: DUF393; cl01136 269796005149 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 269796005150 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 269796005151 putative dimer interface [polypeptide binding]; other site 269796005152 [2Fe-2S] cluster binding site [ion binding]; other site 269796005153 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 269796005154 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 269796005155 SLBB domain; Region: SLBB; pfam10531 269796005156 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 269796005157 NADH dehydrogenase subunit G; Validated; Region: PRK09130 269796005158 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269796005159 catalytic loop [active] 269796005160 iron binding site [ion binding]; other site 269796005161 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 269796005162 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 269796005163 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 269796005164 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 269796005165 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 269796005166 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 269796005167 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 269796005168 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 269796005169 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 269796005170 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 269796005171 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 269796005172 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269796005173 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 269796005174 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 269796005175 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269796005176 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 269796005177 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269796005178 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 269796005179 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 269796005180 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 269796005181 pantothenate kinase; Reviewed; Region: PRK13318 269796005182 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 269796005183 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 269796005184 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 269796005185 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 269796005186 dimer interface [polypeptide binding]; other site 269796005187 substrate binding site [chemical binding]; other site 269796005188 metal binding site [ion binding]; metal-binding site 269796005189 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 269796005190 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 269796005191 prolyl-tRNA synthetase; Provisional; Region: PRK12325 269796005192 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 269796005193 dimer interface [polypeptide binding]; other site 269796005194 motif 1; other site 269796005195 active site 269796005196 motif 2; other site 269796005197 motif 3; other site 269796005198 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 269796005199 anticodon binding site; other site 269796005200 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 269796005201 DJ-1 family protein; Region: not_thiJ; TIGR01383 269796005202 conserved cys residue [active] 269796005203 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 269796005204 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 269796005205 FtsX-like permease family; Region: FtsX; pfam02687 269796005206 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 269796005207 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 269796005208 Walker A/P-loop; other site 269796005209 ATP binding site [chemical binding]; other site 269796005210 Q-loop/lid; other site 269796005211 ABC transporter signature motif; other site 269796005212 Walker B; other site 269796005213 D-loop; other site 269796005214 H-loop/switch region; other site 269796005215 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 269796005216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269796005217 Coenzyme A binding pocket [chemical binding]; other site 269796005218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 269796005219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269796005220 Coenzyme A binding pocket [chemical binding]; other site 269796005221 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 269796005222 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 269796005223 putative active site [active] 269796005224 putative PHP Thumb interface [polypeptide binding]; other site 269796005225 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 269796005226 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 269796005227 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 269796005228 generic binding surface I; other site 269796005229 generic binding surface II; other site 269796005230 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269796005231 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796005232 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796005233 dimer interface [polypeptide binding]; other site 269796005234 putative CheW interface [polypeptide binding]; other site 269796005235 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269796005236 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796005237 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796005238 dimer interface [polypeptide binding]; other site 269796005239 putative CheW interface [polypeptide binding]; other site 269796005240 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 269796005241 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 269796005242 rRNA interaction site [nucleotide binding]; other site 269796005243 S8 interaction site; other site 269796005244 putative laminin-1 binding site; other site 269796005245 elongation factor Ts; Provisional; Region: tsf; PRK09377 269796005246 UBA/TS-N domain; Region: UBA; pfam00627 269796005247 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 269796005248 putative nucleotide binding site [chemical binding]; other site 269796005249 uridine monophosphate binding site [chemical binding]; other site 269796005250 homohexameric interface [polypeptide binding]; other site 269796005251 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 269796005252 hinge region; other site 269796005253 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 269796005254 active site 269796005255 dimer interface [polypeptide binding]; other site 269796005256 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 269796005257 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 269796005258 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 269796005259 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 269796005260 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 269796005261 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 269796005262 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 269796005263 active site 269796005264 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 269796005265 protein binding site [polypeptide binding]; other site 269796005266 putative substrate binding region [chemical binding]; other site 269796005267 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 269796005268 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269796005269 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269796005270 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269796005271 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269796005272 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269796005273 Surface antigen; Region: Bac_surface_Ag; pfam01103 269796005274 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 269796005275 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 269796005276 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 269796005277 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 269796005278 active site 269796005279 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 269796005280 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 269796005281 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 269796005282 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 269796005283 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 269796005284 dimer interface [polypeptide binding]; other site 269796005285 active site 269796005286 citrylCoA binding site [chemical binding]; other site 269796005287 NADH binding [chemical binding]; other site 269796005288 cationic pore residues; other site 269796005289 oxalacetate/citrate binding site [chemical binding]; other site 269796005290 coenzyme A binding site [chemical binding]; other site 269796005291 catalytic triad [active] 269796005292 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 269796005293 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 269796005294 active site 269796005295 HIGH motif; other site 269796005296 KMSKS motif; other site 269796005297 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 269796005298 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 269796005299 Competence protein; Region: Competence; pfam03772 269796005300 PhoH-like protein; Region: PhoH; pfam02562 269796005301 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 269796005302 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 269796005303 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 269796005304 active site 269796005305 homodimer interface [polypeptide binding]; other site 269796005306 catalytic site [active] 269796005307 acceptor binding site [chemical binding]; other site 269796005308 trehalose synthase; Region: treS_nterm; TIGR02456 269796005309 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 269796005310 active site 269796005311 catalytic site [active] 269796005312 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 269796005313 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl19286 269796005314 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 269796005315 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 269796005316 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 269796005317 active site 269796005318 catalytic site [active] 269796005319 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 269796005320 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 269796005321 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 269796005322 Mechanosensitive ion channel; Region: MS_channel; pfam00924 269796005323 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 269796005324 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 269796005325 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796005326 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 269796005327 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 269796005328 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 269796005329 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269796005330 catalytic residue [active] 269796005331 3-mercaptopyruvate sulfurtransferase; Region: PLN02723 269796005332 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 269796005333 active site residue [active] 269796005334 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 269796005335 active site residue [active] 269796005336 cysteine synthase; Region: PLN02565 269796005337 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 269796005338 dimer interface [polypeptide binding]; other site 269796005339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796005340 catalytic residue [active] 269796005341 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 269796005342 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 269796005343 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 269796005344 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 269796005345 FMN binding site [chemical binding]; other site 269796005346 active site 269796005347 catalytic residues [active] 269796005348 substrate binding site [chemical binding]; other site 269796005349 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 269796005350 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269796005351 ligand binding site [chemical binding]; other site 269796005352 flexible hinge region; other site 269796005353 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 269796005354 putative switch regulator; other site 269796005355 non-specific DNA interactions [nucleotide binding]; other site 269796005356 DNA binding site [nucleotide binding] 269796005357 sequence specific DNA binding site [nucleotide binding]; other site 269796005358 putative cAMP binding site [chemical binding]; other site 269796005359 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 269796005360 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 269796005361 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 269796005362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796005363 S-adenosylmethionine binding site [chemical binding]; other site 269796005364 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 269796005365 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 269796005366 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 269796005367 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 269796005368 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 269796005369 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269796005370 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 269796005371 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269796005372 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 269796005373 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269796005374 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 269796005375 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12508 269796005376 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12504 269796005377 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 269796005378 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 269796005379 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 269796005380 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 269796005381 NMT1/THI5 like; Region: NMT1; pfam09084 269796005382 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 269796005383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796005384 dimer interface [polypeptide binding]; other site 269796005385 conserved gate region; other site 269796005386 putative PBP binding loops; other site 269796005387 ABC-ATPase subunit interface; other site 269796005388 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 269796005389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796005390 Walker A/P-loop; other site 269796005391 ATP binding site [chemical binding]; other site 269796005392 ABC transporter signature motif; other site 269796005393 Walker B; other site 269796005394 D-loop; other site 269796005395 H-loop/switch region; other site 269796005396 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 269796005397 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 269796005398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 269796005399 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 269796005400 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 269796005401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796005402 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796005403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796005404 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 269796005405 dimerization interface [polypeptide binding]; other site 269796005406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796005407 active site 269796005408 phosphorylation site [posttranslational modification] 269796005409 intermolecular recognition site; other site 269796005410 dimerization interface [polypeptide binding]; other site 269796005411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796005412 PAS domain; Region: PAS_9; pfam13426 269796005413 putative active site [active] 269796005414 heme pocket [chemical binding]; other site 269796005415 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796005416 metal binding site [ion binding]; metal-binding site 269796005417 active site 269796005418 I-site; other site 269796005419 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796005420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796005421 active site 269796005422 phosphorylation site [posttranslational modification] 269796005423 intermolecular recognition site; other site 269796005424 dimerization interface [polypeptide binding]; other site 269796005425 Hemerythrin; Region: Hemerythrin; cd12107 269796005426 Fe binding site [ion binding]; other site 269796005427 GcrA cell cycle regulator; Region: GcrA; cl11564 269796005428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796005429 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796005430 putative substrate translocation pore; other site 269796005431 acyl-CoA synthetase; Validated; Region: PRK08162 269796005432 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 269796005433 acyl-activating enzyme (AAE) consensus motif; other site 269796005434 putative active site [active] 269796005435 AMP binding site [chemical binding]; other site 269796005436 putative CoA binding site [chemical binding]; other site 269796005437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796005438 putative active site [active] 269796005439 heme pocket [chemical binding]; other site 269796005440 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269796005441 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 269796005442 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796005443 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 269796005444 Peptidase family M23; Region: Peptidase_M23; pfam01551 269796005445 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 269796005446 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 269796005447 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981 269796005448 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 269796005449 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 269796005450 putative phosphate acyltransferase; Provisional; Region: PRK05331 269796005451 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 269796005452 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 269796005453 dimer interface [polypeptide binding]; other site 269796005454 active site 269796005455 CoA binding pocket [chemical binding]; other site 269796005456 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 269796005457 DNA binding site [nucleotide binding] 269796005458 dimer interface [polypeptide binding]; other site 269796005459 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 269796005460 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 269796005461 DNA binding residues [nucleotide binding] 269796005462 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 269796005463 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 269796005464 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 269796005465 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 269796005466 substrate binding site; other site 269796005467 dimer interface; other site 269796005468 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 269796005469 homotrimer interaction site [polypeptide binding]; other site 269796005470 zinc binding site [ion binding]; other site 269796005471 CDP-binding sites; other site 269796005472 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 269796005473 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 269796005474 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 269796005475 FMN binding site [chemical binding]; other site 269796005476 active site 269796005477 catalytic residues [active] 269796005478 substrate binding site [chemical binding]; other site 269796005479 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 269796005480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796005481 putative active site [active] 269796005482 heme pocket [chemical binding]; other site 269796005483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796005484 dimer interface [polypeptide binding]; other site 269796005485 phosphorylation site [posttranslational modification] 269796005486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796005487 ATP binding site [chemical binding]; other site 269796005488 Mg2+ binding site [ion binding]; other site 269796005489 G-X-G motif; other site 269796005490 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 269796005491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796005492 active site 269796005493 phosphorylation site [posttranslational modification] 269796005494 intermolecular recognition site; other site 269796005495 dimerization interface [polypeptide binding]; other site 269796005496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796005497 Walker A motif; other site 269796005498 ATP binding site [chemical binding]; other site 269796005499 Walker B motif; other site 269796005500 arginine finger; other site 269796005501 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 269796005502 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 269796005503 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796005504 dimerization interface [polypeptide binding]; other site 269796005505 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796005506 putative active site [active] 269796005507 heme pocket [chemical binding]; other site 269796005508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796005509 dimer interface [polypeptide binding]; other site 269796005510 phosphorylation site [posttranslational modification] 269796005511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796005512 ATP binding site [chemical binding]; other site 269796005513 Mg2+ binding site [ion binding]; other site 269796005514 G-X-G motif; other site 269796005515 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269796005516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796005517 active site 269796005518 phosphorylation site [posttranslational modification] 269796005519 intermolecular recognition site; other site 269796005520 dimerization interface [polypeptide binding]; other site 269796005521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796005522 Walker A motif; other site 269796005523 ATP binding site [chemical binding]; other site 269796005524 Walker B motif; other site 269796005525 arginine finger; other site 269796005526 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269796005527 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 269796005528 TrkA-N domain; Region: TrkA_N; pfam02254 269796005529 TrkA-C domain; Region: TrkA_C; pfam02080 269796005530 TrkA-N domain; Region: TrkA_N; pfam02254 269796005531 TrkA-C domain; Region: TrkA_C; pfam02080 269796005532 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 269796005533 homodimer interface [polypeptide binding]; other site 269796005534 substrate-cofactor binding pocket; other site 269796005535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796005536 catalytic residue [active] 269796005537 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 269796005538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269796005539 active site 269796005540 motif I; other site 269796005541 motif II; other site 269796005542 bacterial Hfq-like; Region: Hfq; cd01716 269796005543 hexamer interface [polypeptide binding]; other site 269796005544 Sm1 motif; other site 269796005545 RNA binding site [nucleotide binding]; other site 269796005546 Sm2 motif; other site 269796005547 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 269796005548 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 269796005549 HflX GTPase family; Region: HflX; cd01878 269796005550 G1 box; other site 269796005551 GTP/Mg2+ binding site [chemical binding]; other site 269796005552 Switch I region; other site 269796005553 G2 box; other site 269796005554 G3 box; other site 269796005555 Switch II region; other site 269796005556 G4 box; other site 269796005557 G5 box; other site 269796005558 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 269796005559 active site 269796005560 putative lithium-binding site [ion binding]; other site 269796005561 substrate binding site [chemical binding]; other site 269796005562 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 269796005563 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 269796005564 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 269796005565 homodimer interface [polypeptide binding]; other site 269796005566 metal binding site [ion binding]; metal-binding site 269796005567 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 269796005568 homodimer interface [polypeptide binding]; other site 269796005569 active site 269796005570 putative chemical substrate binding site [chemical binding]; other site 269796005571 metal binding site [ion binding]; metal-binding site 269796005572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796005573 S-adenosylmethionine binding site [chemical binding]; other site 269796005574 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 269796005575 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 269796005576 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 269796005577 dimer interface [polypeptide binding]; other site 269796005578 active site 269796005579 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 269796005580 catalytic residues [active] 269796005581 substrate binding site [chemical binding]; other site 269796005582 EcsC protein family; Region: EcsC; pfam12787 269796005583 Protein of unknown function, DUF; Region: DUF411; cl01142 269796005584 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 269796005585 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 269796005586 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 269796005587 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 269796005588 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 269796005589 active site 269796005590 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 269796005591 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 269796005592 active site 269796005593 HIGH motif; other site 269796005594 KMSKS motif; other site 269796005595 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 269796005596 tRNA binding surface [nucleotide binding]; other site 269796005597 anticodon binding site; other site 269796005598 DNA polymerase III subunit delta'; Validated; Region: PRK07471 269796005599 DNA polymerase III subunit delta'; Validated; Region: PRK08485 269796005600 thymidylate kinase; Validated; Region: tmk; PRK00698 269796005601 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 269796005602 TMP-binding site; other site 269796005603 ATP-binding site [chemical binding]; other site 269796005604 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 269796005605 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 269796005606 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 269796005607 rare lipoprotein A; Provisional; Region: PRK10672 269796005608 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 269796005609 Sporulation related domain; Region: SPOR; pfam05036 269796005610 lytic murein transglycosylase; Region: MltB_2; TIGR02283 269796005611 Transglycosylase SLT domain; Region: SLT_2; pfam13406 269796005612 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 269796005613 N-acetyl-D-glucosamine binding site [chemical binding]; other site 269796005614 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 269796005615 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 269796005616 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 269796005617 oligomeric interface; other site 269796005618 putative active site [active] 269796005619 homodimer interface [polypeptide binding]; other site 269796005620 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 269796005621 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 269796005622 homotrimer interaction site [polypeptide binding]; other site 269796005623 putative active site [active] 269796005624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796005625 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 269796005626 putative active site [active] 269796005627 heme pocket [chemical binding]; other site 269796005628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796005629 putative active site [active] 269796005630 heme pocket [chemical binding]; other site 269796005631 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796005632 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796005633 dimer interface [polypeptide binding]; other site 269796005634 putative CheW interface [polypeptide binding]; other site 269796005635 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 269796005636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796005637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796005638 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 269796005639 putative effector binding pocket; other site 269796005640 dimerization interface [polypeptide binding]; other site 269796005641 Predicted transporter component [General function prediction only]; Region: COG2391 269796005642 Sulphur transport; Region: Sulf_transp; pfam04143 269796005643 Predicted transporter component [General function prediction only]; Region: COG2391 269796005644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 269796005645 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269796005646 dimerization interface [polypeptide binding]; other site 269796005647 putative DNA binding site [nucleotide binding]; other site 269796005648 putative Zn2+ binding site [ion binding]; other site 269796005649 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 269796005650 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 269796005651 THF binding site; other site 269796005652 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 269796005653 substrate binding site [chemical binding]; other site 269796005654 THF binding site; other site 269796005655 zinc-binding site [ion binding]; other site 269796005656 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 269796005657 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 269796005658 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 269796005659 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 269796005660 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 269796005661 catalytic triad [active] 269796005662 conserved cis-peptide bond; other site 269796005663 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 269796005664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 269796005665 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 269796005666 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 269796005667 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 269796005668 potential catalytic triad [active] 269796005669 conserved cys residue [active] 269796005670 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 269796005671 active site 269796005672 zinc binding site [ion binding]; other site 269796005673 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 269796005674 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 269796005675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269796005676 ATP binding site [chemical binding]; other site 269796005677 putative Mg++ binding site [ion binding]; other site 269796005678 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269796005679 nucleotide binding region [chemical binding]; other site 269796005680 ATP-binding site [chemical binding]; other site 269796005681 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 269796005682 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 269796005683 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 269796005684 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 269796005685 ssDNA binding site; other site 269796005686 generic binding surface II; other site 269796005687 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269796005688 ATP binding site [chemical binding]; other site 269796005689 putative Mg++ binding site [ion binding]; other site 269796005690 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269796005691 nucleotide binding region [chemical binding]; other site 269796005692 ATP-binding site [chemical binding]; other site 269796005693 Uncharacterized conserved protein [Function unknown]; Region: COG2928 269796005694 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 269796005695 Catalytic site; other site 269796005696 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 269796005697 Lysin motif; Region: LysM; smart00257 269796005698 Sporulation related domain; Region: SPOR; pfam05036 269796005699 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 269796005700 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 269796005701 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 269796005702 YcfA-like protein; Region: YcfA; cl00752 269796005703 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 269796005704 active site 269796005705 catalytic residues [active] 269796005706 DNA binding site [nucleotide binding] 269796005707 Int/Topo IB signature motif; other site 269796005708 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 269796005709 active site 269796005710 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 269796005711 active site 269796005712 (T/H)XGH motif; other site 269796005713 DNA gyrase subunit A; Validated; Region: PRK05560 269796005714 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 269796005715 CAP-like domain; other site 269796005716 active site 269796005717 primary dimer interface [polypeptide binding]; other site 269796005718 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269796005719 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269796005720 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269796005721 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269796005722 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269796005723 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269796005724 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 269796005725 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 269796005726 dimer interface [polypeptide binding]; other site 269796005727 ssDNA binding site [nucleotide binding]; other site 269796005728 tetramer (dimer of dimers) interface [polypeptide binding]; other site 269796005729 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 269796005730 dimerization interface [polypeptide binding]; other site 269796005731 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 269796005732 ligand binding site [chemical binding]; other site 269796005733 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 269796005734 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 269796005735 Walker A/P-loop; other site 269796005736 ATP binding site [chemical binding]; other site 269796005737 Q-loop/lid; other site 269796005738 ABC transporter signature motif; other site 269796005739 Walker B; other site 269796005740 D-loop; other site 269796005741 H-loop/switch region; other site 269796005742 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 269796005743 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 269796005744 Walker A/P-loop; other site 269796005745 ATP binding site [chemical binding]; other site 269796005746 Q-loop/lid; other site 269796005747 ABC transporter signature motif; other site 269796005748 Walker B; other site 269796005749 D-loop; other site 269796005750 H-loop/switch region; other site 269796005751 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 269796005752 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 269796005753 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 269796005754 TM-ABC transporter signature motif; other site 269796005755 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 269796005756 TM-ABC transporter signature motif; other site 269796005757 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 269796005758 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 269796005759 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 269796005760 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 269796005761 High-affinity nickel-transport protein; Region: NicO; cl00964 269796005762 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 269796005763 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 269796005764 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 269796005765 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 269796005766 Glucose inhibited division protein A; Region: GIDA; pfam01134 269796005767 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 269796005768 substrate binding pocket [chemical binding]; other site 269796005769 substrate-Mg2+ binding site; other site 269796005770 aspartate-rich region 1; other site 269796005771 aspartate-rich region 2; other site 269796005772 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 269796005773 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 269796005774 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 269796005775 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 269796005776 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269796005777 Coenzyme A binding pocket [chemical binding]; other site 269796005778 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 269796005779 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 269796005780 Protein export membrane protein; Region: SecD_SecF; pfam02355 269796005781 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 269796005782 MMPL family; Region: MMPL; cl14618 269796005783 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 269796005784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796005785 Walker A motif; other site 269796005786 ATP binding site [chemical binding]; other site 269796005787 Walker B motif; other site 269796005788 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 269796005789 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 269796005790 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 269796005791 Peptidase family M23; Region: Peptidase_M23; pfam01551 269796005792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796005793 S-adenosylmethionine binding site [chemical binding]; other site 269796005794 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 269796005795 seryl-tRNA synthetase; Provisional; Region: PRK05431 269796005796 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 269796005797 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 269796005798 dimer interface [polypeptide binding]; other site 269796005799 active site 269796005800 motif 1; other site 269796005801 motif 2; other site 269796005802 motif 3; other site 269796005803 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 269796005804 sec-independent translocase; Provisional; Region: tatB; PRK00404 269796005805 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 269796005806 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 269796005807 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 269796005808 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 269796005809 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 269796005810 Peptidase family M50; Region: Peptidase_M50; pfam02163 269796005811 active site 269796005812 putative substrate binding region [chemical binding]; other site 269796005813 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 269796005814 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 269796005815 Sporulation related domain; Region: SPOR; pfam05036 269796005816 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 269796005817 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 269796005818 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 269796005819 active site 269796005820 HIGH motif; other site 269796005821 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 269796005822 KMSK motif region; other site 269796005823 tRNA binding surface [nucleotide binding]; other site 269796005824 DALR anticodon binding domain; Region: DALR_1; smart00836 269796005825 anticodon binding site; other site 269796005826 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 269796005827 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269796005828 Zn2+ binding site [ion binding]; other site 269796005829 Mg2+ binding site [ion binding]; other site 269796005830 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 269796005831 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 269796005832 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 269796005833 E-class dimer interface [polypeptide binding]; other site 269796005834 P-class dimer interface [polypeptide binding]; other site 269796005835 active site 269796005836 Cu2+ binding site [ion binding]; other site 269796005837 Zn2+ binding site [ion binding]; other site 269796005838 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 269796005839 putative catalytic site [active] 269796005840 putative phosphate binding site [ion binding]; other site 269796005841 active site 269796005842 metal binding site A [ion binding]; metal-binding site 269796005843 DNA binding site [nucleotide binding] 269796005844 putative AP binding site [nucleotide binding]; other site 269796005845 putative metal binding site B [ion binding]; other site 269796005846 Predicted membrane protein [Function unknown]; Region: COG3671 269796005847 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 269796005848 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 269796005849 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269796005850 ligand binding site [chemical binding]; other site 269796005851 flexible hinge region; other site 269796005852 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 269796005853 putative switch regulator; other site 269796005854 non-specific DNA interactions [nucleotide binding]; other site 269796005855 DNA binding site [nucleotide binding] 269796005856 sequence specific DNA binding site [nucleotide binding]; other site 269796005857 putative cAMP binding site [chemical binding]; other site 269796005858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796005859 phosphorylation site [posttranslational modification] 269796005860 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 269796005861 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 269796005862 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 269796005863 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 269796005864 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 269796005865 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 269796005866 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 269796005867 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 269796005868 Walker A/P-loop; other site 269796005869 ATP binding site [chemical binding]; other site 269796005870 Q-loop/lid; other site 269796005871 ABC transporter signature motif; other site 269796005872 Walker B; other site 269796005873 D-loop; other site 269796005874 H-loop/switch region; other site 269796005875 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 269796005876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796005877 Walker A/P-loop; other site 269796005878 ATP binding site [chemical binding]; other site 269796005879 Q-loop/lid; other site 269796005880 ABC transporter signature motif; other site 269796005881 Walker B; other site 269796005882 D-loop; other site 269796005883 H-loop/switch region; other site 269796005884 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 269796005885 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269796005886 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796005887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796005888 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 269796005889 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 269796005890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269796005891 active site 269796005892 motif I; other site 269796005893 motif II; other site 269796005894 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 269796005895 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 269796005896 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 269796005897 active site 269796005898 HIGH motif; other site 269796005899 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 269796005900 KMSKS motif; other site 269796005901 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 269796005902 tRNA binding surface [nucleotide binding]; other site 269796005903 anticodon binding site; other site 269796005904 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 269796005905 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 269796005906 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 269796005907 Outer membrane efflux protein; Region: OEP; pfam02321 269796005908 Outer membrane efflux protein; Region: OEP; pfam02321 269796005909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796005910 S-adenosylmethionine binding site [chemical binding]; other site 269796005911 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 269796005912 PAS fold; Region: PAS_3; pfam08447 269796005913 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796005914 putative active site [active] 269796005915 heme pocket [chemical binding]; other site 269796005916 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796005917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796005918 dimer interface [polypeptide binding]; other site 269796005919 putative CheW interface [polypeptide binding]; other site 269796005920 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 269796005921 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 269796005922 CoA binding domain; Region: CoA_binding_2; pfam13380 269796005923 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 269796005924 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 269796005925 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 269796005926 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 269796005927 PAS fold; Region: PAS_4; pfam08448 269796005928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796005929 putative active site [active] 269796005930 heme pocket [chemical binding]; other site 269796005931 GAF domain; Region: GAF_2; pfam13185 269796005932 PAS domain; Region: PAS_9; pfam13426 269796005933 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796005934 putative active site [active] 269796005935 heme pocket [chemical binding]; other site 269796005936 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796005937 metal binding site [ion binding]; metal-binding site 269796005938 active site 269796005939 I-site; other site 269796005940 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796005941 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 269796005942 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 269796005943 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 269796005944 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269796005945 ligand binding site [chemical binding]; other site 269796005946 RNA polymerase sigma factor; Provisional; Region: PRK11924 269796005947 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269796005948 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 269796005949 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 269796005950 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 269796005951 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 269796005952 metal binding site [ion binding]; metal-binding site 269796005953 putative dimer interface [polypeptide binding]; other site 269796005954 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 269796005955 putative hydrophobic ligand binding site [chemical binding]; other site 269796005956 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 269796005957 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 269796005958 dimerization interface [polypeptide binding]; other site 269796005959 ligand binding site [chemical binding]; other site 269796005960 NADP binding site [chemical binding]; other site 269796005961 catalytic site [active] 269796005962 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 269796005963 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 269796005964 PGAP1-like protein; Region: PGAP1; pfam07819 269796005965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796005966 binding surface 269796005967 TPR motif; other site 269796005968 Tetratricopeptide repeat; Region: TPR_12; pfam13424 269796005969 Tetratricopeptide repeat; Region: TPR_12; pfam13424 269796005970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796005971 binding surface 269796005972 TPR motif; other site 269796005973 Tetratricopeptide repeat; Region: TPR_12; pfam13424 269796005974 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 269796005975 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 269796005976 thiamine monophosphate kinase; Provisional; Region: PRK05731 269796005977 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 269796005978 ATP binding site [chemical binding]; other site 269796005979 dimerization interface [polypeptide binding]; other site 269796005980 transcription antitermination factor NusB; Region: nusB; TIGR01951 269796005981 putative RNA binding site [nucleotide binding]; other site 269796005982 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 269796005983 homopentamer interface [polypeptide binding]; other site 269796005984 active site 269796005985 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 269796005986 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 269796005987 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 269796005988 dimerization interface [polypeptide binding]; other site 269796005989 active site 269796005990 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 269796005991 Lumazine binding domain; Region: Lum_binding; pfam00677 269796005992 Lumazine binding domain; Region: Lum_binding; pfam00677 269796005993 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 269796005994 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 269796005995 catalytic motif [active] 269796005996 Zn binding site [ion binding]; other site 269796005997 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 269796005998 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 269796005999 ATP cone domain; Region: ATP-cone; pfam03477 269796006000 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 269796006001 dimer interface [polypeptide binding]; other site 269796006002 active site 269796006003 glycine-pyridoxal phosphate binding site [chemical binding]; other site 269796006004 folate binding site [chemical binding]; other site 269796006005 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 269796006006 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 269796006007 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 269796006008 active site 269796006009 GTP cyclohydrolase I; Region: GTP_cyclohydroI; pfam01227 269796006010 active site 269796006011 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 269796006012 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 269796006013 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 269796006014 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 269796006015 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269796006016 substrate binding site [chemical binding]; other site 269796006017 oxyanion hole (OAH) forming residues; other site 269796006018 trimer interface [polypeptide binding]; other site 269796006019 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 269796006020 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 269796006021 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 269796006022 active site 269796006023 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 269796006024 homodimer interface [polypeptide binding]; other site 269796006025 substrate-cofactor binding pocket; other site 269796006026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796006027 catalytic residue [active] 269796006028 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 269796006029 dimer interface [polypeptide binding]; other site 269796006030 active site 269796006031 aspartate-rich active site metal binding site; other site 269796006032 allosteric magnesium binding site [ion binding]; other site 269796006033 Schiff base residues; other site 269796006034 Putative lysophospholipase; Region: Hydrolase_4; cl19140 269796006035 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 269796006036 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 269796006037 Penicillin amidase; Region: Penicil_amidase; pfam01804 269796006038 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 269796006039 active site 269796006040 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 269796006041 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 269796006042 flagellar motor protein MotB; Validated; Region: motB; PRK09041 269796006043 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 269796006044 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269796006045 ligand binding site [chemical binding]; other site 269796006046 RDD family; Region: RDD; pfam06271 269796006047 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 269796006048 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 269796006049 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 269796006050 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 269796006051 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 269796006052 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 269796006053 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 269796006054 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 269796006055 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 269796006056 CAP-like domain; other site 269796006057 active site 269796006058 primary dimer interface [polypeptide binding]; other site 269796006059 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 269796006060 Recombination protein O N terminal; Region: RecO_N; pfam11967 269796006061 Recombination protein O C terminal; Region: RecO_C; pfam02565 269796006062 GTPase Era; Reviewed; Region: era; PRK00089 269796006063 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 269796006064 G1 box; other site 269796006065 GTP/Mg2+ binding site [chemical binding]; other site 269796006066 Switch I region; other site 269796006067 G2 box; other site 269796006068 Switch II region; other site 269796006069 G3 box; other site 269796006070 G4 box; other site 269796006071 G5 box; other site 269796006072 KH domain; Region: KH_2; pfam07650 269796006073 ribonuclease III; Reviewed; Region: rnc; PRK00102 269796006074 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 269796006075 dimerization interface [polypeptide binding]; other site 269796006076 active site 269796006077 metal binding site [ion binding]; metal-binding site 269796006078 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 269796006079 dsRNA binding site [nucleotide binding]; other site 269796006080 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 269796006081 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 269796006082 Catalytic site [active] 269796006083 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 269796006084 active site 269796006085 hydrophilic channel; other site 269796006086 dimerization interface [polypeptide binding]; other site 269796006087 catalytic residues [active] 269796006088 active site lid [active] 269796006089 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 269796006090 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 269796006091 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269796006092 Zn2+ binding site [ion binding]; other site 269796006093 Mg2+ binding site [ion binding]; other site 269796006094 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 269796006095 synthetase active site [active] 269796006096 NTP binding site [chemical binding]; other site 269796006097 metal binding site [ion binding]; metal-binding site 269796006098 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 269796006099 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 269796006100 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 269796006101 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 269796006102 catalytic center binding site [active] 269796006103 ATP binding site [chemical binding]; other site 269796006104 Uncharacterized conserved protein [Function unknown]; Region: COG1432 269796006105 LabA_like proteins; Region: LabA; cd10911 269796006106 putative metal binding site [ion binding]; other site 269796006107 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 269796006108 Fe-S cluster binding site [ion binding]; other site 269796006109 DNA binding site [nucleotide binding] 269796006110 active site 269796006111 Tetratricopeptide repeat; Region: TPR_6; pfam13174 269796006112 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 269796006113 catalytic residues [active] 269796006114 dimer interface [polypeptide binding]; other site 269796006115 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 269796006116 SmpB-tmRNA interface; other site 269796006117 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 269796006118 dimer interface [polypeptide binding]; other site 269796006119 active site 269796006120 catalytic residue [active] 269796006121 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 269796006122 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 269796006123 N-acetyl-D-glucosamine binding site [chemical binding]; other site 269796006124 catalytic residue [active] 269796006125 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 269796006126 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 269796006127 Peptidase family M23; Region: Peptidase_M23; pfam01551 269796006128 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 269796006129 tetramer interfaces [polypeptide binding]; other site 269796006130 binuclear metal-binding site [ion binding]; other site 269796006131 Competence-damaged protein; Region: CinA; pfam02464 269796006132 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 269796006133 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 269796006134 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 269796006135 PhoU domain; Region: PhoU; pfam01895 269796006136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796006137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796006138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 269796006139 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796006140 EamA-like transporter family; Region: EamA; pfam00892 269796006141 EamA-like transporter family; Region: EamA; pfam00892 269796006142 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796006143 PAS fold; Region: PAS_3; pfam08447 269796006144 putative active site [active] 269796006145 heme pocket [chemical binding]; other site 269796006146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796006147 dimer interface [polypeptide binding]; other site 269796006148 phosphorylation site [posttranslational modification] 269796006149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796006150 ATP binding site [chemical binding]; other site 269796006151 Mg2+ binding site [ion binding]; other site 269796006152 G-X-G motif; other site 269796006153 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 269796006154 putative coenzyme Q binding site [chemical binding]; other site 269796006155 lipoyl synthase; Provisional; Region: PRK05481 269796006156 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796006157 FeS/SAM binding site; other site 269796006158 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 269796006159 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796006160 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269796006161 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 269796006162 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 269796006163 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 269796006164 E3 interaction surface; other site 269796006165 lipoyl attachment site [posttranslational modification]; other site 269796006166 e3 binding domain; Region: E3_binding; pfam02817 269796006167 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 269796006168 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 269796006169 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 269796006170 E3 interaction surface; other site 269796006171 lipoyl attachment site [posttranslational modification]; other site 269796006172 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 269796006173 alpha subunit interface [polypeptide binding]; other site 269796006174 TPP binding site [chemical binding]; other site 269796006175 heterodimer interface [polypeptide binding]; other site 269796006176 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 269796006177 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 269796006178 tetramer interface [polypeptide binding]; other site 269796006179 TPP-binding site [chemical binding]; other site 269796006180 heterodimer interface [polypeptide binding]; other site 269796006181 phosphorylation loop region [posttranslational modification] 269796006182 Septum formation initiator; Region: DivIC; cl17659 269796006183 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 269796006184 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 269796006185 Cl binding site [ion binding]; other site 269796006186 oligomer interface [polypeptide binding]; other site 269796006187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796006188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796006189 dimer interface [polypeptide binding]; other site 269796006190 phosphorylation site [posttranslational modification] 269796006191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796006192 ATP binding site [chemical binding]; other site 269796006193 Mg2+ binding site [ion binding]; other site 269796006194 G-X-G motif; other site 269796006195 enolase; Provisional; Region: eno; PRK00077 269796006196 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 269796006197 dimer interface [polypeptide binding]; other site 269796006198 metal binding site [ion binding]; metal-binding site 269796006199 substrate binding pocket [chemical binding]; other site 269796006200 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 269796006201 CTP synthetase; Validated; Region: pyrG; PRK05380 269796006202 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 269796006203 Catalytic site [active] 269796006204 active site 269796006205 UTP binding site [chemical binding]; other site 269796006206 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 269796006207 active site 269796006208 putative oxyanion hole; other site 269796006209 catalytic triad [active] 269796006210 protein translocase, SecG subunit; Region: secG; TIGR00810 269796006211 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 269796006212 substrate binding site [chemical binding]; other site 269796006213 dimer interface [polypeptide binding]; other site 269796006214 catalytic triad [active] 269796006215 periplasmic folding chaperone; Provisional; Region: PRK10788 269796006216 SurA N-terminal domain; Region: SurA_N_3; cl07813 269796006217 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 269796006218 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 269796006219 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 269796006220 anthranilate synthase component I; Provisional; Region: PRK13573 269796006221 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 269796006222 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 269796006223 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 269796006224 metal-binding site [ion binding] 269796006225 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 269796006226 NodB motif; other site 269796006227 putative active site [active] 269796006228 putative catalytic site [active] 269796006229 Zn binding site [ion binding]; other site 269796006230 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 269796006231 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 269796006232 metal-binding site [ion binding] 269796006233 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 269796006234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269796006235 motif II; other site 269796006236 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 269796006237 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 269796006238 glutamine binding [chemical binding]; other site 269796006239 catalytic triad [active] 269796006240 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 269796006241 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 269796006242 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 269796006243 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 269796006244 active site 269796006245 ribulose/triose binding site [chemical binding]; other site 269796006246 phosphate binding site [ion binding]; other site 269796006247 substrate (anthranilate) binding pocket [chemical binding]; other site 269796006248 product (indole) binding pocket [chemical binding]; other site 269796006249 LexA repressor; Validated; Region: PRK00215 269796006250 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 269796006251 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 269796006252 Catalytic site [active] 269796006253 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 269796006254 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 269796006255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269796006256 putative DNA binding site [nucleotide binding]; other site 269796006257 putative Zn2+ binding site [ion binding]; other site 269796006258 AsnC family; Region: AsnC_trans_reg; pfam01037 269796006259 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 269796006260 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796006261 dimerization interface [polypeptide binding]; other site 269796006262 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796006263 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796006264 dimer interface [polypeptide binding]; other site 269796006265 putative CheW interface [polypeptide binding]; other site 269796006266 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 269796006267 putative ligand binding site [chemical binding]; other site 269796006268 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 269796006269 TM-ABC transporter signature motif; other site 269796006270 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 269796006271 TM-ABC transporter signature motif; other site 269796006272 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 269796006273 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 269796006274 Walker A/P-loop; other site 269796006275 ATP binding site [chemical binding]; other site 269796006276 Q-loop/lid; other site 269796006277 ABC transporter signature motif; other site 269796006278 Walker B; other site 269796006279 D-loop; other site 269796006280 H-loop/switch region; other site 269796006281 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 269796006282 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 269796006283 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 269796006284 Sulfate transporter family; Region: Sulfate_transp; cl19250 269796006285 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 269796006286 SelR domain; Region: SelR; cl15841 269796006287 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269796006288 active site 269796006289 phosphorylation site [posttranslational modification] 269796006290 intermolecular recognition site; other site 269796006291 PAS domain S-box; Region: sensory_box; TIGR00229 269796006292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796006293 putative active site [active] 269796006294 heme pocket [chemical binding]; other site 269796006295 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796006296 metal binding site [ion binding]; metal-binding site 269796006297 active site 269796006298 I-site; other site 269796006299 polyadenylate binding protein, human types 1, 2, 3, 4 family; Region: PABP-1234; TIGR01628 269796006300 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 269796006301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796006302 S-adenosylmethionine binding site [chemical binding]; other site 269796006303 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 269796006304 metal binding site 2 [ion binding]; metal-binding site 269796006305 putative DNA binding helix; other site 269796006306 metal binding site 1 [ion binding]; metal-binding site 269796006307 dimer interface [polypeptide binding]; other site 269796006308 structural Zn2+ binding site [ion binding]; other site 269796006309 oxidoreductase; Validated; Region: PRK05717 269796006310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269796006311 NAD(P) binding site [chemical binding]; other site 269796006312 active site 269796006313 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 269796006314 DNA-binding site [nucleotide binding]; DNA binding site 269796006315 RNA-binding motif; other site 269796006316 helicase 45; Provisional; Region: PTZ00424 269796006317 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 269796006318 ATP binding site [chemical binding]; other site 269796006319 Mg++ binding site [ion binding]; other site 269796006320 motif III; other site 269796006321 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269796006322 nucleotide binding region [chemical binding]; other site 269796006323 ATP-binding site [chemical binding]; other site 269796006324 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269796006325 catalytic loop [active] 269796006326 iron binding site [ion binding]; other site 269796006327 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 269796006328 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 269796006329 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 269796006330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796006331 dimer interface [polypeptide binding]; other site 269796006332 conserved gate region; other site 269796006333 putative PBP binding loops; other site 269796006334 ABC-ATPase subunit interface; other site 269796006335 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 269796006336 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 269796006337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796006338 dimer interface [polypeptide binding]; other site 269796006339 conserved gate region; other site 269796006340 putative PBP binding loops; other site 269796006341 ABC-ATPase subunit interface; other site 269796006342 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 269796006343 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796006344 Walker A/P-loop; other site 269796006345 ATP binding site [chemical binding]; other site 269796006346 Q-loop/lid; other site 269796006347 ABC transporter signature motif; other site 269796006348 Walker B; other site 269796006349 D-loop; other site 269796006350 H-loop/switch region; other site 269796006351 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 269796006352 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 269796006353 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796006354 Walker A/P-loop; other site 269796006355 ATP binding site [chemical binding]; other site 269796006356 Q-loop/lid; other site 269796006357 ABC transporter signature motif; other site 269796006358 Walker B; other site 269796006359 D-loop; other site 269796006360 H-loop/switch region; other site 269796006361 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 269796006362 catalytic residues [active] 269796006363 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 269796006364 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 269796006365 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 269796006366 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 269796006367 DNA-binding site [nucleotide binding]; DNA binding site 269796006368 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269796006369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796006370 homodimer interface [polypeptide binding]; other site 269796006371 catalytic residue [active] 269796006372 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 269796006373 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 269796006374 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 269796006375 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 269796006376 2-isopropylmalate synthase; Validated; Region: PRK03739 269796006377 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 269796006378 active site 269796006379 catalytic residues [active] 269796006380 metal binding site [ion binding]; metal-binding site 269796006381 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 269796006382 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 269796006383 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 269796006384 Active Sites [active] 269796006385 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 269796006386 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 269796006387 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 269796006388 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 269796006389 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 269796006390 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 269796006391 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 269796006392 siroheme synthase; Provisional; Region: cysG; PRK10637 269796006393 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 269796006394 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 269796006395 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 269796006396 active site 269796006397 SAM binding site [chemical binding]; other site 269796006398 homodimer interface [polypeptide binding]; other site 269796006399 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796006400 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796006401 Autoinducer binding domain; Region: Autoind_bind; pfam03472 269796006402 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 269796006403 DNA binding residues [nucleotide binding] 269796006404 dimerization interface [polypeptide binding]; other site 269796006405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 269796006406 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 269796006407 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 269796006408 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 269796006409 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269796006410 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 269796006411 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 269796006412 probable active site [active] 269796006413 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 269796006414 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 269796006415 active site 269796006416 catalytic residues [active] 269796006417 metal binding site [ion binding]; metal-binding site 269796006418 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 269796006419 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269796006420 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269796006421 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 269796006422 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 269796006423 carboxyltransferase (CT) interaction site; other site 269796006424 biotinylation site [posttranslational modification]; other site 269796006425 enoyl-CoA hydratase; Provisional; Region: PRK05995 269796006426 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269796006427 substrate binding site [chemical binding]; other site 269796006428 oxyanion hole (OAH) forming residues; other site 269796006429 trimer interface [polypeptide binding]; other site 269796006430 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 269796006431 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 269796006432 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 269796006433 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 269796006434 putative catalytic residue [active] 269796006435 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 269796006436 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 269796006437 NADP binding site [chemical binding]; other site 269796006438 homodimer interface [polypeptide binding]; other site 269796006439 active site 269796006440 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 269796006441 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 269796006442 dimer interface [polypeptide binding]; other site 269796006443 active site 269796006444 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 269796006445 isovaleryl-CoA dehydrogenase; Region: PLN02519 269796006446 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 269796006447 substrate binding site [chemical binding]; other site 269796006448 FAD binding site [chemical binding]; other site 269796006449 catalytic base [active] 269796006450 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 269796006451 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 269796006452 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 269796006453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796006454 Fusaric acid resistance protein family; Region: FUSC; pfam04632 269796006455 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 269796006456 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 269796006457 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269796006458 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796006459 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269796006460 active site 269796006461 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 269796006462 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269796006463 motif II; other site 269796006464 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 269796006465 Ligand Binding Site [chemical binding]; other site 269796006466 IMP dehydrogenase / GMP reductase domain; Region: IMPDH; pfam00478 269796006467 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 269796006468 active site 269796006469 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 269796006470 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796006471 FeS/SAM binding site; other site 269796006472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796006473 S-adenosylmethionine binding site [chemical binding]; other site 269796006474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796006475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796006476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 269796006477 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 269796006478 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 269796006479 adenylosuccinate lyase; Provisional; Region: PRK07492 269796006480 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 269796006481 tetramer interface [polypeptide binding]; other site 269796006482 active site 269796006483 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 269796006484 adenylosuccinate synthetase; Provisional; Region: PRK04293 269796006485 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 269796006486 Peptidase S8 family domain, uncharacterized subfamily 10; Region: Peptidases_S8_10; cd07494 269796006487 Subtilase family; Region: Peptidase_S8; pfam00082 269796006488 active site 269796006489 catalytic triad [active] 269796006490 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 269796006491 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 269796006492 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 269796006493 active site 269796006494 P-loop; other site 269796006495 phosphorylation site [posttranslational modification] 269796006496 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 269796006497 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 269796006498 active site 269796006499 P-loop; other site 269796006500 phosphorylation site [posttranslational modification] 269796006501 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 269796006502 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 269796006503 putative substrate binding site [chemical binding]; other site 269796006504 putative ATP binding site [chemical binding]; other site 269796006505 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 269796006506 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 269796006507 active site 269796006508 phosphorylation site [posttranslational modification] 269796006509 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 269796006510 dimerization domain swap beta strand [polypeptide binding]; other site 269796006511 regulatory protein interface [polypeptide binding]; other site 269796006512 active site 269796006513 regulatory phosphorylation site [posttranslational modification]; other site 269796006514 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 269796006515 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 269796006516 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 269796006517 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 269796006518 Transcriptional regulators [Transcription]; Region: PurR; COG1609 269796006519 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 269796006520 DNA binding site [nucleotide binding] 269796006521 domain linker motif; other site 269796006522 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280 269796006523 putative dimerization interface [polypeptide binding]; other site 269796006524 putative ligand binding site [chemical binding]; other site 269796006525 HipA N-terminal domain; Region: Couple_hipA; cl11853 269796006526 HipA-like N-terminal domain; Region: HipA_N; pfam07805 269796006527 HipA-like C-terminal domain; Region: HipA_C; pfam07804 269796006528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796006529 non-specific DNA binding site [nucleotide binding]; other site 269796006530 salt bridge; other site 269796006531 sequence-specific DNA binding site [nucleotide binding]; other site 269796006532 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269796006533 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 269796006534 acyl-activating enzyme (AAE) consensus motif; other site 269796006535 AMP binding site [chemical binding]; other site 269796006536 active site 269796006537 CoA binding site [chemical binding]; other site 269796006538 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 269796006539 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 269796006540 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 269796006541 dimer interface [polypeptide binding]; other site 269796006542 PYR/PP interface [polypeptide binding]; other site 269796006543 TPP binding site [chemical binding]; other site 269796006544 substrate binding site [chemical binding]; other site 269796006545 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 269796006546 TPP-binding site; other site 269796006547 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 269796006548 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 269796006549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796006550 catalytic residue [active] 269796006551 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 269796006552 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 269796006553 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 269796006554 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 269796006555 active site 269796006556 Zn binding site [ion binding]; other site 269796006557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 269796006558 SEC-C motif; Region: SEC-C; cl19389 269796006559 SEC-C motif; Region: SEC-C; cl19389 269796006560 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 269796006561 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 269796006562 Abi-like protein; Region: Abi_2; pfam07751 269796006563 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 269796006564 putative oligomer interface [polypeptide binding]; other site 269796006565 putative active site [active] 269796006566 metal binding site [ion binding]; metal-binding site 269796006567 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 269796006568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269796006569 Coenzyme A binding pocket [chemical binding]; other site 269796006570 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269796006571 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 269796006572 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 269796006573 active site 269796006574 dimer interface [polypeptide binding]; other site 269796006575 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 269796006576 Ligand Binding Site [chemical binding]; other site 269796006577 Molecular Tunnel; other site 269796006578 Protein of unknown function (DUF2393); Region: DUF2393; cl19577 269796006579 Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622 269796006580 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 269796006581 catalytic residues [active] 269796006582 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 269796006583 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 269796006584 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 269796006585 DNA binding residues [nucleotide binding] 269796006586 putative dimer interface [polypeptide binding]; other site 269796006587 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 269796006588 MgtE intracellular N domain; Region: MgtE_N; pfam03448 269796006589 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 269796006590 Divalent cation transporter; Region: MgtE; cl00786 269796006591 lipoate-protein ligase B; Provisional; Region: PRK14341 269796006592 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 269796006593 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 269796006594 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 269796006595 Ribulose bisphosphate carboxylase like proteins (RLPs) similar to R.rubrum RLP; Region: RLP_RrRLP; cd08210 269796006596 dimer interface [polypeptide binding]; other site 269796006597 active site 269796006598 catalytic residue [active] 269796006599 metal binding site [ion binding]; metal-binding site 269796006600 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 269796006601 Cupin domain; Region: Cupin_2; pfam07883 269796006602 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 269796006603 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 269796006604 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 269796006605 putative ligand binding site [chemical binding]; other site 269796006606 NAD binding site [chemical binding]; other site 269796006607 dimerization interface [polypeptide binding]; other site 269796006608 catalytic site [active] 269796006609 hypothetical protein; Provisional; Region: PRK01254 269796006610 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 269796006611 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 269796006612 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 269796006613 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796006614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796006615 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 269796006616 dimerization interface [polypeptide binding]; other site 269796006617 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 269796006618 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 269796006619 FAD binding site [chemical binding]; other site 269796006620 substrate binding pocket [chemical binding]; other site 269796006621 catalytic base [active] 269796006622 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 269796006623 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796006624 EamA-like transporter family; Region: EamA; pfam00892 269796006625 EamA-like transporter family; Region: EamA; pfam00892 269796006626 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 269796006627 ThiC-associated domain; Region: ThiC-associated; pfam13667 269796006628 ThiC family; Region: ThiC; pfam01964 269796006629 glycerol kinase; Provisional; Region: glpK; PRK00047 269796006630 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 269796006631 N- and C-terminal domain interface [polypeptide binding]; other site 269796006632 active site 269796006633 MgATP binding site [chemical binding]; other site 269796006634 catalytic site [active] 269796006635 metal binding site [ion binding]; metal-binding site 269796006636 glycerol binding site [chemical binding]; other site 269796006637 homotetramer interface [polypeptide binding]; other site 269796006638 homodimer interface [polypeptide binding]; other site 269796006639 FBP binding site [chemical binding]; other site 269796006640 protein IIAGlc interface [polypeptide binding]; other site 269796006641 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 269796006642 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269796006643 catalytic residue [active] 269796006644 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 269796006645 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796006646 Walker A/P-loop; other site 269796006647 ATP binding site [chemical binding]; other site 269796006648 Q-loop/lid; other site 269796006649 ABC transporter signature motif; other site 269796006650 Walker B; other site 269796006651 D-loop; other site 269796006652 H-loop/switch region; other site 269796006653 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 269796006654 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796006655 Walker A/P-loop; other site 269796006656 ATP binding site [chemical binding]; other site 269796006657 Q-loop/lid; other site 269796006658 ABC transporter signature motif; other site 269796006659 Walker B; other site 269796006660 D-loop; other site 269796006661 H-loop/switch region; other site 269796006662 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 269796006663 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 269796006664 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 269796006665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796006666 dimer interface [polypeptide binding]; other site 269796006667 conserved gate region; other site 269796006668 putative PBP binding loops; other site 269796006669 ABC-ATPase subunit interface; other site 269796006670 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 269796006671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796006672 dimer interface [polypeptide binding]; other site 269796006673 conserved gate region; other site 269796006674 putative PBP binding loops; other site 269796006675 ABC-ATPase subunit interface; other site 269796006676 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 269796006677 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 269796006678 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 269796006679 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 269796006680 HSP70 interaction site [polypeptide binding]; other site 269796006681 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 269796006682 substrate binding site [polypeptide binding]; other site 269796006683 dimer interface [polypeptide binding]; other site 269796006684 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 269796006685 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 269796006686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796006687 non-specific DNA binding site [nucleotide binding]; other site 269796006688 salt bridge; other site 269796006689 sequence-specific DNA binding site [nucleotide binding]; other site 269796006690 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 269796006691 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 269796006692 putative catalytic site [active] 269796006693 putative metal binding site [ion binding]; other site 269796006694 putative phosphate binding site [ion binding]; other site 269796006695 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796006696 dimerization interface [polypeptide binding]; other site 269796006697 PAS domain; Region: PAS_9; pfam13426 269796006698 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796006699 dimer interface [polypeptide binding]; other site 269796006700 putative CheW interface [polypeptide binding]; other site 269796006701 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 269796006702 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 269796006703 Ligand Binding Site [chemical binding]; other site 269796006704 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 269796006705 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269796006706 catalytic loop [active] 269796006707 iron binding site [ion binding]; other site 269796006708 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 269796006709 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269796006710 catalytic residue [active] 269796006711 Transcriptional regulator; Region: Rrf2; cl17282 269796006712 Rrf2 family protein; Region: rrf2_super; TIGR00738 269796006713 serine O-acetyltransferase; Region: cysE; TIGR01172 269796006714 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 269796006715 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 269796006716 trimer interface [polypeptide binding]; other site 269796006717 active site 269796006718 substrate binding site [chemical binding]; other site 269796006719 CoA binding site [chemical binding]; other site 269796006720 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 269796006721 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 269796006722 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 269796006723 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 269796006724 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 269796006725 active site 269796006726 HIGH motif; other site 269796006727 dimer interface [polypeptide binding]; other site 269796006728 KMSKS motif; other site 269796006729 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 269796006730 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796006731 putative active site [active] 269796006732 heme pocket [chemical binding]; other site 269796006733 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796006734 dimer interface [polypeptide binding]; other site 269796006735 phosphorylation site [posttranslational modification] 269796006736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796006737 ATP binding site [chemical binding]; other site 269796006738 Mg2+ binding site [ion binding]; other site 269796006739 G-X-G motif; other site 269796006740 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796006741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796006742 active site 269796006743 phosphorylation site [posttranslational modification] 269796006744 intermolecular recognition site; other site 269796006745 dimerization interface [polypeptide binding]; other site 269796006746 Phosphate transporter family; Region: PHO4; pfam01384 269796006747 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 269796006748 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 269796006749 Protein of unknown function; Region: DUF3971; pfam13116 269796006750 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 269796006751 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 269796006752 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 269796006753 metal binding triad; other site 269796006754 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 269796006755 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 269796006756 metal binding triad; other site 269796006757 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 269796006758 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 269796006759 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 269796006760 catalytic triad [active] 269796006761 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 269796006762 peptide chain release factor 2; Provisional; Region: PRK07342 269796006763 This domain is found in peptide chain release factors; Region: PCRF; smart00937 269796006764 RF-1 domain; Region: RF-1; pfam00472 269796006765 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 269796006766 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 269796006767 inhibitor-cofactor binding pocket; inhibition site 269796006768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796006769 catalytic residue [active] 269796006770 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 269796006771 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796006772 non-specific DNA binding site [nucleotide binding]; other site 269796006773 salt bridge; other site 269796006774 sequence-specific DNA binding site [nucleotide binding]; other site 269796006775 Cupin domain; Region: Cupin_2; pfam07883 269796006776 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 269796006777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796006778 dimer interface [polypeptide binding]; other site 269796006779 conserved gate region; other site 269796006780 putative PBP binding loops; other site 269796006781 ABC-ATPase subunit interface; other site 269796006782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796006783 dimer interface [polypeptide binding]; other site 269796006784 conserved gate region; other site 269796006785 putative PBP binding loops; other site 269796006786 ABC-ATPase subunit interface; other site 269796006787 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 269796006788 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227 269796006789 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 269796006790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796006791 Walker A/P-loop; other site 269796006792 ATP binding site [chemical binding]; other site 269796006793 Q-loop/lid; other site 269796006794 ABC transporter signature motif; other site 269796006795 Walker B; other site 269796006796 D-loop; other site 269796006797 H-loop/switch region; other site 269796006798 TOBE domain; Region: TOBE_2; pfam08402 269796006799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796006800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796006801 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 269796006802 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 269796006803 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269796006804 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796006805 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 269796006806 MMPL family; Region: MMPL; cl14618 269796006807 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 269796006808 Outer membrane efflux protein; Region: OEP; pfam02321 269796006809 Outer membrane efflux protein; Region: OEP; pfam02321 269796006810 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 269796006811 Hpt domain; Region: Hpt; pfam01627 269796006812 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 269796006813 tandem repeat interface [polypeptide binding]; other site 269796006814 oligomer interface [polypeptide binding]; other site 269796006815 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 269796006816 active site residues [active] 269796006817 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 269796006818 active site clefts [active] 269796006819 zinc binding site [ion binding]; other site 269796006820 dimer interface [polypeptide binding]; other site 269796006821 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 269796006822 Walker A motif; other site 269796006823 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 269796006824 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796006825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796006826 dimer interface [polypeptide binding]; other site 269796006827 phosphorylation site [posttranslational modification] 269796006828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796006829 ATP binding site [chemical binding]; other site 269796006830 Mg2+ binding site [ion binding]; other site 269796006831 G-X-G motif; other site 269796006832 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 269796006833 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269796006834 Zn2+ binding site [ion binding]; other site 269796006835 Mg2+ binding site [ion binding]; other site 269796006836 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 269796006837 FAD binding domain; Region: FAD_binding_4; pfam01565 269796006838 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 269796006839 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 269796006840 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 269796006841 PRC-barrel domain; Region: PRC; pfam05239 269796006842 Transcriptional regulators [Transcription]; Region: GntR; COG1802 269796006843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 269796006844 DNA-binding site [nucleotide binding]; DNA binding site 269796006845 FCD domain; Region: FCD; pfam07729 269796006846 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796006847 FAD dependent oxidoreductase; Region: DAO; pfam01266 269796006848 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796006849 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 269796006850 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 269796006851 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 269796006852 inhibitor site; inhibition site 269796006853 active site 269796006854 dimer interface [polypeptide binding]; other site 269796006855 catalytic residue [active] 269796006856 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 269796006857 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 269796006858 active site 269796006859 dimer interfaces [polypeptide binding]; other site 269796006860 catalytic residues [active] 269796006861 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 269796006862 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 269796006863 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796006864 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 269796006865 tetrameric interface [polypeptide binding]; other site 269796006866 NAD binding site [chemical binding]; other site 269796006867 catalytic residues [active] 269796006868 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 269796006869 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 269796006870 dimer interface [polypeptide binding]; other site 269796006871 anticodon binding site; other site 269796006872 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 269796006873 homodimer interface [polypeptide binding]; other site 269796006874 motif 1; other site 269796006875 active site 269796006876 motif 2; other site 269796006877 GAD domain; Region: GAD; pfam02938 269796006878 motif 3; other site 269796006879 ribonuclease D; Region: rnd; TIGR01388 269796006880 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 269796006881 catalytic site [active] 269796006882 putative active site [active] 269796006883 putative substrate binding site [chemical binding]; other site 269796006884 HRDC domain; Region: HRDC; pfam00570 269796006885 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 269796006886 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 269796006887 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 269796006888 homodimer interface [polypeptide binding]; other site 269796006889 substrate-cofactor binding pocket; other site 269796006890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796006891 catalytic residue [active] 269796006892 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 269796006893 HAMP domain; Region: HAMP; pfam00672 269796006894 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796006895 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796006896 dimer interface [polypeptide binding]; other site 269796006897 putative CheW interface [polypeptide binding]; other site 269796006898 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 269796006899 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796006900 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796006901 dimer interface [polypeptide binding]; other site 269796006902 putative CheW interface [polypeptide binding]; other site 269796006903 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 269796006904 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 269796006905 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 269796006906 Hemerythrin; Region: Hemerythrin; cd12107 269796006907 Fe binding site [ion binding]; other site 269796006908 CreA protein; Region: CreA; pfam05981 269796006909 hypothetical protein; Provisional; Region: PRK08912 269796006910 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269796006911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796006912 homodimer interface [polypeptide binding]; other site 269796006913 catalytic residue [active] 269796006914 Nitrogen regulatory protein P-II; Region: P-II; smart00938 269796006915 glutamine synthetase; Provisional; Region: glnA; PRK09469 269796006916 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 269796006917 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 269796006918 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 269796006919 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 269796006920 substrate binding pocket [chemical binding]; other site 269796006921 membrane-bound complex binding site; other site 269796006922 hinge residues; other site 269796006923 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 269796006924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796006925 dimer interface [polypeptide binding]; other site 269796006926 conserved gate region; other site 269796006927 putative PBP binding loops; other site 269796006928 ABC-ATPase subunit interface; other site 269796006929 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 269796006930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796006931 dimer interface [polypeptide binding]; other site 269796006932 conserved gate region; other site 269796006933 putative PBP binding loops; other site 269796006934 ABC-ATPase subunit interface; other site 269796006935 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 269796006936 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 269796006937 Walker A/P-loop; other site 269796006938 ATP binding site [chemical binding]; other site 269796006939 Q-loop/lid; other site 269796006940 ABC transporter signature motif; other site 269796006941 Walker B; other site 269796006942 D-loop; other site 269796006943 H-loop/switch region; other site 269796006944 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 269796006945 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 269796006946 MMPL family; Region: MMPL; cl14618 269796006947 MMPL family; Region: MMPL; cl14618 269796006948 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 269796006949 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 269796006950 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796006951 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 269796006952 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 269796006953 AAA-like domain; Region: AAA_10; pfam12846 269796006954 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 269796006955 PAS domain; Region: PAS_5; cl19562 269796006956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 269796006957 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 269796006958 Family of unknown function (DUF490); Region: DUF490; pfam04357 269796006959 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 269796006960 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269796006961 Surface antigen; Region: Bac_surface_Ag; pfam01103 269796006962 Predicted permeases [General function prediction only]; Region: COG0730 269796006963 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269796006964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796006965 active site 269796006966 phosphorylation site [posttranslational modification] 269796006967 intermolecular recognition site; other site 269796006968 dimerization interface [polypeptide binding]; other site 269796006969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796006970 Walker A motif; other site 269796006971 ATP binding site [chemical binding]; other site 269796006972 Walker B motif; other site 269796006973 arginine finger; other site 269796006974 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269796006975 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 269796006976 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 269796006977 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796006978 Walker A/P-loop; other site 269796006979 ATP binding site [chemical binding]; other site 269796006980 Q-loop/lid; other site 269796006981 ABC transporter signature motif; other site 269796006982 Walker B; other site 269796006983 D-loop; other site 269796006984 H-loop/switch region; other site 269796006985 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 269796006986 TM-ABC transporter signature motif; other site 269796006987 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 269796006988 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 269796006989 zinc binding site [ion binding]; other site 269796006990 putative ligand binding site [chemical binding]; other site 269796006991 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 269796006992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 269796006993 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796006994 PAS domain; Region: PAS_8; pfam13188 269796006995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796006996 dimer interface [polypeptide binding]; other site 269796006997 phosphorylation site [posttranslational modification] 269796006998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796006999 ATP binding site [chemical binding]; other site 269796007000 Mg2+ binding site [ion binding]; other site 269796007001 G-X-G motif; other site 269796007002 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796007003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796007004 active site 269796007005 phosphorylation site [posttranslational modification] 269796007006 intermolecular recognition site; other site 269796007007 dimerization interface [polypeptide binding]; other site 269796007008 Hpt domain; Region: Hpt; pfam01627 269796007009 putative binding surface; other site 269796007010 active site 269796007011 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 269796007012 Clp amino terminal domain; Region: Clp_N; pfam02861 269796007013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796007014 Walker A motif; other site 269796007015 ATP binding site [chemical binding]; other site 269796007016 Walker B motif; other site 269796007017 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 269796007018 arginine finger; other site 269796007019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796007020 Walker A motif; other site 269796007021 ATP binding site [chemical binding]; other site 269796007022 Walker B motif; other site 269796007023 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 269796007024 Uncharacterized conserved protein [Function unknown]; Region: COG2127 269796007025 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 269796007026 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 269796007027 Sporulation related domain; Region: SPOR; pfam05036 269796007028 O-Antigen ligase; Region: Wzy_C; pfam04932 269796007029 phosphoglucomutase; Region: PLN02307 269796007030 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 269796007031 active site 269796007032 substrate binding site [chemical binding]; other site 269796007033 metal binding site [ion binding]; metal-binding site 269796007034 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 269796007035 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 269796007036 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 269796007037 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 269796007038 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 269796007039 active site 269796007040 tetramer interface; other site 269796007041 ATPase MipZ; Region: MipZ; pfam09140 269796007042 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 269796007043 P-loop; other site 269796007044 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 269796007045 Magnesium ion binding site [ion binding]; other site 269796007046 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 269796007047 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 269796007048 putative [4Fe-4S] binding site [ion binding]; other site 269796007049 putative molybdopterin cofactor binding site [chemical binding]; other site 269796007050 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 269796007051 putative molybdopterin cofactor binding site; other site 269796007052 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 269796007053 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 269796007054 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796007055 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796007056 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 269796007057 Methyltransferase domain; Region: Methyltransf_31; pfam13847 269796007058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796007059 S-adenosylmethionine binding site [chemical binding]; other site 269796007060 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 269796007061 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 269796007062 Ligand binding site; other site 269796007063 Putative Catalytic site; other site 269796007064 DXD motif; other site 269796007065 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 269796007066 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 269796007067 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 269796007068 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 269796007069 malonic semialdehyde reductase; Provisional; Region: PRK10538 269796007070 putative NAD(P) binding site [chemical binding]; other site 269796007071 homodimer interface [polypeptide binding]; other site 269796007072 homotetramer interface [polypeptide binding]; other site 269796007073 active site 269796007074 LytTr DNA-binding domain; Region: LytTR; smart00850 269796007075 fumarate hydratase; Reviewed; Region: fumC; PRK00485 269796007076 Class II fumarases; Region: Fumarase_classII; cd01362 269796007077 active site 269796007078 tetramer interface [polypeptide binding]; other site 269796007079 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 269796007080 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 269796007081 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 269796007082 Ligand binding site; other site 269796007083 DXD motif; other site 269796007084 Acyltransferase family; Region: Acyl_transf_3; cl19154 269796007085 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 269796007086 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 269796007087 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 269796007088 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 269796007089 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269796007090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796007091 non-specific DNA binding site [nucleotide binding]; other site 269796007092 salt bridge; other site 269796007093 sequence-specific DNA binding site [nucleotide binding]; other site 269796007094 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 269796007095 Catalytic site [active] 269796007096 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796007097 EamA-like transporter family; Region: EamA; pfam00892 269796007098 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796007099 dimer interface [polypeptide binding]; other site 269796007100 putative CheW interface [polypeptide binding]; other site 269796007101 Methyltransferase domain; Region: Methyltransf_31; pfam13847 269796007102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796007103 S-adenosylmethionine binding site [chemical binding]; other site 269796007104 Uncharacterized protein conserved in bacteria (DUF2084); Region: DUF2084; pfam09857 269796007105 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796007106 dimer interface [polypeptide binding]; other site 269796007107 putative CheW interface [polypeptide binding]; other site 269796007108 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 269796007109 Transglycosylase; Region: Transgly; pfam00912 269796007110 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 269796007111 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 269796007112 AMIN domain; Region: AMIN; pfam11741 269796007113 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 269796007114 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 269796007115 active site 269796007116 metal binding site [ion binding]; metal-binding site 269796007117 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 269796007118 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 269796007119 homodimer interface [polypeptide binding]; other site 269796007120 oligonucleotide binding site [chemical binding]; other site 269796007121 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 269796007122 Serine-rich region of AP3B1, clathrin-adaptor complex; Region: SEEEED; cl19208 269796007123 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 269796007124 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 269796007125 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 269796007126 23S rRNA interface [nucleotide binding]; other site 269796007127 L3 interface [polypeptide binding]; other site 269796007128 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 269796007129 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 269796007130 TolR protein; Region: tolR; TIGR02801 269796007131 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 269796007132 enoyl-CoA hydratase; Validated; Region: PRK08139 269796007133 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269796007134 substrate binding site [chemical binding]; other site 269796007135 oxyanion hole (OAH) forming residues; other site 269796007136 trimer interface [polypeptide binding]; other site 269796007137 CHAP domain; Region: CHAP; cl17642 269796007138 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269796007139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796007140 active site 269796007141 phosphorylation site [posttranslational modification] 269796007142 intermolecular recognition site; other site 269796007143 dimerization interface [polypeptide binding]; other site 269796007144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796007145 Walker A motif; other site 269796007146 ATP binding site [chemical binding]; other site 269796007147 Walker B motif; other site 269796007148 arginine finger; other site 269796007149 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269796007150 Creatinine amidohydrolase; Region: Creatininase; pfam02633 269796007151 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 269796007152 exopolyphosphatase; Region: exo_poly_only; TIGR03706 269796007153 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 269796007154 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 269796007155 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 269796007156 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 269796007157 putative domain interface [polypeptide binding]; other site 269796007158 putative active site [active] 269796007159 catalytic site [active] 269796007160 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 269796007161 putative domain interface [polypeptide binding]; other site 269796007162 putative active site [active] 269796007163 catalytic site [active] 269796007164 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 269796007165 catalytic core [active] 269796007166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 269796007167 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 269796007168 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 269796007169 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 269796007170 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; cl19834 269796007171 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 269796007172 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 269796007173 dimerization interface [polypeptide binding]; other site 269796007174 putative ATP binding site [chemical binding]; other site 269796007175 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 269796007176 active site 269796007177 substrate binding site [chemical binding]; other site 269796007178 cosubstrate binding site; other site 269796007179 catalytic site [active] 269796007180 Nucleoside diphosphate kinase; Region: NDK; pfam00334 269796007181 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 269796007182 active site 269796007183 multimer interface [polypeptide binding]; other site 269796007184 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 269796007185 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269796007186 ABC transporter; Region: ABC_tran_2; pfam12848 269796007187 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269796007188 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 269796007189 dimerization interface [polypeptide binding]; other site 269796007190 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 269796007191 ligand binding site [chemical binding]; other site 269796007192 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 269796007193 interface (dimer of trimers) [polypeptide binding]; other site 269796007194 Substrate-binding/catalytic site; other site 269796007195 Zn-binding sites [ion binding]; other site 269796007196 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 269796007197 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796007198 Walker A/P-loop; other site 269796007199 ATP binding site [chemical binding]; other site 269796007200 Q-loop/lid; other site 269796007201 ABC transporter signature motif; other site 269796007202 Walker B; other site 269796007203 D-loop; other site 269796007204 H-loop/switch region; other site 269796007205 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 269796007206 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 269796007207 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796007208 Walker A/P-loop; other site 269796007209 ATP binding site [chemical binding]; other site 269796007210 Q-loop/lid; other site 269796007211 ABC transporter signature motif; other site 269796007212 Walker B; other site 269796007213 D-loop; other site 269796007214 H-loop/switch region; other site 269796007215 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 269796007216 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 269796007217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796007218 dimer interface [polypeptide binding]; other site 269796007219 conserved gate region; other site 269796007220 putative PBP binding loops; other site 269796007221 ABC-ATPase subunit interface; other site 269796007222 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 269796007223 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 269796007224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796007225 dimer interface [polypeptide binding]; other site 269796007226 conserved gate region; other site 269796007227 putative PBP binding loops; other site 269796007228 ABC-ATPase subunit interface; other site 269796007229 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 269796007230 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 269796007231 peptide binding site [polypeptide binding]; other site 269796007232 Autoinducer binding domain; Region: Autoind_bind; pfam03472 269796007233 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 269796007234 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 269796007235 DNA binding residues [nucleotide binding] 269796007236 dimerization interface [polypeptide binding]; other site 269796007237 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 269796007238 Putative lysophospholipase; Region: Hydrolase_4; cl19140 269796007239 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 269796007240 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 269796007241 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 269796007242 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 269796007243 ligand binding site [chemical binding]; other site 269796007244 homodimer interface [polypeptide binding]; other site 269796007245 NAD(P) binding site [chemical binding]; other site 269796007246 trimer interface B [polypeptide binding]; other site 269796007247 trimer interface A [polypeptide binding]; other site 269796007248 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576 269796007249 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 269796007250 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 269796007251 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 269796007252 dimer interface [polypeptide binding]; other site 269796007253 PYR/PP interface [polypeptide binding]; other site 269796007254 TPP binding site [chemical binding]; other site 269796007255 substrate binding site [chemical binding]; other site 269796007256 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 269796007257 TPP-binding site [chemical binding]; other site 269796007258 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 269796007259 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 269796007260 DDE superfamily endonuclease; Region: DDE_3; cl19249 269796007261 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 269796007262 Catalytic domain of Protein Kinases; Region: PKc; cd00180 269796007263 active site 269796007264 ATP binding site [chemical binding]; other site 269796007265 substrate binding site [chemical binding]; other site 269796007266 activation loop (A-loop); other site 269796007267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 269796007268 Transposase, Mutator family; Region: Transposase_mut; cl19537 269796007269 Transposase, Mutator family; Region: Transposase_mut; cl19537 269796007270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 269796007271 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 269796007272 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 269796007273 acyl-activating enzyme (AAE) consensus motif; other site 269796007274 putative AMP binding site [chemical binding]; other site 269796007275 putative active site [active] 269796007276 putative CoA binding site [chemical binding]; other site 269796007277 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 269796007278 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 269796007279 active site 269796007280 Zn binding site [ion binding]; other site 269796007281 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 269796007282 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 269796007283 putative active site [active] 269796007284 putative catalytic site [active] 269796007285 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 269796007286 Ferritin-like domain; Region: Ferritin; pfam00210 269796007287 heme binding site [chemical binding]; other site 269796007288 ferroxidase pore; other site 269796007289 ferroxidase diiron center [ion binding]; other site 269796007290 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 269796007291 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 269796007292 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 269796007293 homodimer interaction site [polypeptide binding]; other site 269796007294 cofactor binding site; other site 269796007295 DNA polymerase III subunit chi; Validated; Region: PRK05728 269796007296 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 269796007297 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 269796007298 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269796007299 protein binding site [polypeptide binding]; other site 269796007300 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269796007301 protein binding site [polypeptide binding]; other site 269796007302 HflC protein; Region: hflC; TIGR01932 269796007303 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 269796007304 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 269796007305 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 269796007306 HflK protein; Region: hflK; TIGR01933 269796007307 antiporter inner membrane protein; Provisional; Region: PRK11670 269796007308 Domain of unknown function DUF59; Region: DUF59; pfam01883 269796007309 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 269796007310 Walker A motif; other site 269796007311 Stringent starvation protein B; Region: SspB; pfam04386 269796007312 fumarate hydratase; Provisional; Region: PRK15389 269796007313 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 269796007314 Fumarase C-terminus; Region: Fumerase_C; pfam05683 269796007315 TfoX N-terminal domain; Region: TfoX_N; cl17592 269796007316 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 269796007317 AsmA family; Region: AsmA; pfam05170 269796007318 Family of unknown function (DUF490); Region: DUF490; pfam04357 269796007319 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 269796007320 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 269796007321 catalytic core [active] 269796007322 Gram-negative porin; Region: Porin_4; pfam13609 269796007323 Gram-negative porin; Region: Porin_4; pfam13609 269796007324 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 269796007325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796007326 binding surface 269796007327 TPR motif; other site 269796007328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796007329 binding surface 269796007330 TPR motif; other site 269796007331 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 269796007332 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 269796007333 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796007334 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 269796007335 dimerization interface [polypeptide binding]; other site 269796007336 substrate binding pocket [chemical binding]; other site 269796007337 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 269796007338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796007339 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 269796007340 dimerization interface [polypeptide binding]; other site 269796007341 substrate binding pocket [chemical binding]; other site 269796007342 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 269796007343 short chain dehydrogenase; Provisional; Region: PRK09134 269796007344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269796007345 NAD(P) binding site [chemical binding]; other site 269796007346 active site 269796007347 Dihydroneopterin aldolase; Region: FolB; smart00905 269796007348 active site 269796007349 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 269796007350 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 269796007351 GIY-YIG motif/motif A; other site 269796007352 active site 269796007353 catalytic site [active] 269796007354 putative DNA binding site [nucleotide binding]; other site 269796007355 metal binding site [ion binding]; metal-binding site 269796007356 UvrB/uvrC motif; Region: UVR; pfam02151 269796007357 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 269796007358 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 269796007359 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 269796007360 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 269796007361 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 269796007362 dimer interface [polypeptide binding]; other site 269796007363 putative functional site; other site 269796007364 putative MPT binding site; other site 269796007365 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 269796007366 homodimer interface [polypeptide binding]; other site 269796007367 substrate-cofactor binding pocket; other site 269796007368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796007369 catalytic residue [active] 269796007370 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 269796007371 Transcriptional regulators [Transcription]; Region: MarR; COG1846 269796007372 putative DNA binding site [nucleotide binding]; other site 269796007373 putative Zn2+ binding site [ion binding]; other site 269796007374 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796007375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796007376 active site 269796007377 phosphorylation site [posttranslational modification] 269796007378 intermolecular recognition site; other site 269796007379 dimerization interface [polypeptide binding]; other site 269796007380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269796007381 DNA binding site [nucleotide binding] 269796007382 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 269796007383 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796007384 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796007385 dimerization interface [polypeptide binding]; other site 269796007386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796007387 dimer interface [polypeptide binding]; other site 269796007388 phosphorylation site [posttranslational modification] 269796007389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796007390 ATP binding site [chemical binding]; other site 269796007391 Mg2+ binding site [ion binding]; other site 269796007392 G-X-G motif; other site 269796007393 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 269796007394 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 269796007395 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 269796007396 putative binding surface; other site 269796007397 active site 269796007398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796007399 active site 269796007400 phosphorylation site [posttranslational modification] 269796007401 intermolecular recognition site; other site 269796007402 dimerization interface [polypeptide binding]; other site 269796007403 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796007404 metal binding site [ion binding]; metal-binding site 269796007405 active site 269796007406 I-site; other site 269796007407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796007408 active site 269796007409 phosphorylation site [posttranslational modification] 269796007410 intermolecular recognition site; other site 269796007411 dimerization interface [polypeptide binding]; other site 269796007412 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 269796007413 putative active site [active] 269796007414 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 269796007415 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 269796007416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796007417 active site 269796007418 phosphorylation site [posttranslational modification] 269796007419 intermolecular recognition site; other site 269796007420 dimerization interface [polypeptide binding]; other site 269796007421 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 269796007422 DNA binding residues [nucleotide binding] 269796007423 dimerization interface [polypeptide binding]; other site 269796007424 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 269796007425 Transcriptional regulators [Transcription]; Region: MarR; COG1846 269796007426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796007427 active site 269796007428 phosphorylation site [posttranslational modification] 269796007429 intermolecular recognition site; other site 269796007430 dimerization interface [polypeptide binding]; other site 269796007431 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 269796007432 PAS fold; Region: PAS_2; pfam08446 269796007433 GAF domain; Region: GAF; pfam01590 269796007434 Phytochrome region; Region: PHY; pfam00360 269796007435 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796007436 PAS domain; Region: PAS_9; pfam13426 269796007437 putative active site [active] 269796007438 heme pocket [chemical binding]; other site 269796007439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796007440 dimer interface [polypeptide binding]; other site 269796007441 phosphorylation site [posttranslational modification] 269796007442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796007443 ATP binding site [chemical binding]; other site 269796007444 Mg2+ binding site [ion binding]; other site 269796007445 G-X-G motif; other site 269796007446 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 269796007447 Ligand Binding Site [chemical binding]; other site 269796007448 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 269796007449 Ligand Binding Site [chemical binding]; other site 269796007450 DctM-like transporters; Region: DctM; pfam06808 269796007451 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 269796007452 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 269796007453 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 269796007454 enoyl-CoA hydratase; Provisional; Region: PRK07511 269796007455 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269796007456 substrate binding site [chemical binding]; other site 269796007457 oxyanion hole (OAH) forming residues; other site 269796007458 trimer interface [polypeptide binding]; other site 269796007459 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 269796007460 Uncharacterized conserved protein [Function unknown]; Region: COG3791 269796007461 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 269796007462 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 269796007463 homodimer interface [polypeptide binding]; other site 269796007464 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 269796007465 active site pocket [active] 269796007466 glycogen synthase; Provisional; Region: glgA; PRK00654 269796007467 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 269796007468 ADP-binding pocket [chemical binding]; other site 269796007469 homodimer interface [polypeptide binding]; other site 269796007470 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 269796007471 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 269796007472 ligand binding site; other site 269796007473 oligomer interface; other site 269796007474 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 269796007475 dimer interface [polypeptide binding]; other site 269796007476 N-terminal domain interface [polypeptide binding]; other site 269796007477 sulfate 1 binding site; other site 269796007478 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 269796007479 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 269796007480 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269796007481 catalytic residue [active] 269796007482 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 269796007483 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 269796007484 Walker A/P-loop; other site 269796007485 ATP binding site [chemical binding]; other site 269796007486 Q-loop/lid; other site 269796007487 ABC transporter signature motif; other site 269796007488 Walker B; other site 269796007489 D-loop; other site 269796007490 H-loop/switch region; other site 269796007491 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 269796007492 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 269796007493 substrate binding pocket [chemical binding]; other site 269796007494 membrane-bound complex binding site; other site 269796007495 hinge residues; other site 269796007496 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 269796007497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796007498 dimer interface [polypeptide binding]; other site 269796007499 conserved gate region; other site 269796007500 putative PBP binding loops; other site 269796007501 ABC-ATPase subunit interface; other site 269796007502 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 269796007503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796007504 dimer interface [polypeptide binding]; other site 269796007505 conserved gate region; other site 269796007506 putative PBP binding loops; other site 269796007507 ABC-ATPase subunit interface; other site 269796007508 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269796007509 active site 269796007510 Cytochrome C' Region: Cytochrom_C_2; pfam01322 269796007511 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796007512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796007513 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 269796007514 putative effector binding pocket; other site 269796007515 dimerization interface [polypeptide binding]; other site 269796007516 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 269796007517 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 269796007518 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 269796007519 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 269796007520 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 269796007521 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 269796007522 Soluble P-type ATPase [General function prediction only]; Region: COG4087 269796007523 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 269796007524 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796007525 putative oxidoreductase FixC; Provisional; Region: PRK10157 269796007526 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 269796007527 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 269796007528 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 269796007529 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 269796007530 Ligand binding site [chemical binding]; other site 269796007531 Nitrogen fixation protein NifW; Region: NifW; pfam03206 269796007532 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 269796007533 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 269796007534 active site 269796007535 catalytic residues [active] 269796007536 metal binding site [ion binding]; metal-binding site 269796007537 NifU-like domain; Region: NifU; pfam01106 269796007538 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 269796007539 TspO/MBR family; Region: TspO_MBR; pfam03073 269796007540 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 269796007541 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796007542 Walker A/P-loop; other site 269796007543 ATP binding site [chemical binding]; other site 269796007544 Q-loop/lid; other site 269796007545 ABC transporter signature motif; other site 269796007546 Walker B; other site 269796007547 D-loop; other site 269796007548 H-loop/switch region; other site 269796007549 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 269796007550 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796007551 Walker A/P-loop; other site 269796007552 ATP binding site [chemical binding]; other site 269796007553 Q-loop/lid; other site 269796007554 ABC transporter signature motif; other site 269796007555 Walker B; other site 269796007556 D-loop; other site 269796007557 H-loop/switch region; other site 269796007558 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 269796007559 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 269796007560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796007561 dimer interface [polypeptide binding]; other site 269796007562 conserved gate region; other site 269796007563 putative PBP binding loops; other site 269796007564 ABC-ATPase subunit interface; other site 269796007565 nickel transporter permease NikB; Provisional; Region: PRK10352 269796007566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796007567 dimer interface [polypeptide binding]; other site 269796007568 conserved gate region; other site 269796007569 putative PBP binding loops; other site 269796007570 ABC-ATPase subunit interface; other site 269796007571 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 269796007572 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 269796007573 substrate binding site [chemical binding]; other site 269796007574 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 269796007575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796007576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796007577 ATP binding site [chemical binding]; other site 269796007578 Mg2+ binding site [ion binding]; other site 269796007579 G-X-G motif; other site 269796007580 NifQ; Region: NifQ; pfam04891 269796007581 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 269796007582 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269796007583 probable nitrogen fixation protein; Region: TIGR02935 269796007584 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 269796007585 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 269796007586 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 269796007587 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 269796007588 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 269796007589 Uncharacterized conserved protein [Function unknown]; Region: COG2361 269796007590 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 269796007591 active site 269796007592 NTP binding site [chemical binding]; other site 269796007593 metal binding triad [ion binding]; metal-binding site 269796007594 antibiotic binding site [chemical binding]; other site 269796007595 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 269796007596 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 269796007597 Active Sites [active] 269796007598 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 269796007599 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 269796007600 CysD dimerization site [polypeptide binding]; other site 269796007601 G1 box; other site 269796007602 putative GEF interaction site [polypeptide binding]; other site 269796007603 GTP/Mg2+ binding site [chemical binding]; other site 269796007604 Switch I region; other site 269796007605 G2 box; other site 269796007606 G3 box; other site 269796007607 Switch II region; other site 269796007608 G4 box; other site 269796007609 G5 box; other site 269796007610 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 269796007611 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 269796007612 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 269796007613 ligand-binding site [chemical binding]; other site 269796007614 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 269796007615 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 269796007616 active site 269796007617 substrate binding site [chemical binding]; other site 269796007618 Mg2+ binding site [ion binding]; other site 269796007619 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 269796007620 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 269796007621 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 269796007622 active site 269796007623 catalytic site [active] 269796007624 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 269796007625 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 269796007626 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 269796007627 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 269796007628 catalytic site [active] 269796007629 active site 269796007630 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 269796007631 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 269796007632 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 269796007633 substrate binding site [chemical binding]; other site 269796007634 dimer interface [polypeptide binding]; other site 269796007635 ATP binding site [chemical binding]; other site 269796007636 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 269796007637 active site 269796007638 catalytic residues [active] 269796007639 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 269796007640 TM-ABC transporter signature motif; other site 269796007641 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 269796007642 TM-ABC transporter signature motif; other site 269796007643 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 269796007644 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 269796007645 Walker A/P-loop; other site 269796007646 ATP binding site [chemical binding]; other site 269796007647 Q-loop/lid; other site 269796007648 ABC transporter signature motif; other site 269796007649 Walker B; other site 269796007650 D-loop; other site 269796007651 H-loop/switch region; other site 269796007652 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 269796007653 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 269796007654 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 269796007655 ligand binding site [chemical binding]; other site 269796007656 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 269796007657 intersubunit interface [polypeptide binding]; other site 269796007658 active site 269796007659 catalytic residue [active] 269796007660 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 269796007661 HTH domain; Region: HTH_11; cl17392 269796007662 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 269796007663 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 269796007664 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 269796007665 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 269796007666 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269796007667 motif II; other site 269796007668 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 269796007669 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269796007670 dimerization interface [polypeptide binding]; other site 269796007671 putative DNA binding site [nucleotide binding]; other site 269796007672 putative Zn2+ binding site [ion binding]; other site 269796007673 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 269796007674 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269796007675 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 269796007676 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 269796007677 active site residue [active] 269796007678 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 269796007679 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 269796007680 Transcriptional regulator [Transcription]; Region: IclR; COG1414 269796007681 Bacterial transcriptional regulator; Region: IclR; pfam01614 269796007682 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 269796007683 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269796007684 N-terminal plug; other site 269796007685 ligand-binding site [chemical binding]; other site 269796007686 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 269796007687 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 269796007688 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 269796007689 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269796007690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796007691 non-specific DNA binding site [nucleotide binding]; other site 269796007692 salt bridge; other site 269796007693 sequence-specific DNA binding site [nucleotide binding]; other site 269796007694 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 269796007695 Domain of unknown function (DUF955); Region: DUF955; pfam06114 269796007696 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 269796007697 pyruvate carboxylase; Reviewed; Region: PRK12999 269796007698 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269796007699 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269796007700 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 269796007701 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 269796007702 active site 269796007703 catalytic residues [active] 269796007704 metal binding site [ion binding]; metal-binding site 269796007705 homodimer binding site [polypeptide binding]; other site 269796007706 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 269796007707 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 269796007708 carboxyltransferase (CT) interaction site; other site 269796007709 biotinylation site [posttranslational modification]; other site 269796007710 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 269796007711 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 269796007712 methylcitrate synthase; Provisional; Region: PRK12351 269796007713 oxalacetate binding site [chemical binding]; other site 269796007714 citrylCoA binding site [chemical binding]; other site 269796007715 coenzyme A binding site [chemical binding]; other site 269796007716 catalytic triad [active] 269796007717 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 269796007718 tetramer interface [polypeptide binding]; other site 269796007719 active site 269796007720 Mg2+/Mn2+ binding site [ion binding]; other site 269796007721 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796007722 dimer interface [polypeptide binding]; other site 269796007723 putative CheW interface [polypeptide binding]; other site 269796007724 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796007725 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796007726 dimer interface [polypeptide binding]; other site 269796007727 putative CheW interface [polypeptide binding]; other site 269796007728 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 269796007729 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 269796007730 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 269796007731 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 269796007732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796007733 active site 269796007734 phosphorylation site [posttranslational modification] 269796007735 intermolecular recognition site; other site 269796007736 dimerization interface [polypeptide binding]; other site 269796007737 CheB methylesterase; Region: CheB_methylest; pfam01339 269796007738 Protein of unknown function (DUF1800); Region: DUF1800; cl19889 269796007739 HEAT repeats; Region: HEAT_2; pfam13646 269796007740 HEAT repeats; Region: HEAT_2; pfam13646 269796007741 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 269796007742 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 269796007743 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 269796007744 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796007745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796007746 active site 269796007747 phosphorylation site [posttranslational modification] 269796007748 intermolecular recognition site; other site 269796007749 dimerization interface [polypeptide binding]; other site 269796007750 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 269796007751 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 269796007752 putative binding surface; other site 269796007753 active site 269796007754 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 269796007755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796007756 ATP binding site [chemical binding]; other site 269796007757 Mg2+ binding site [ion binding]; other site 269796007758 G-X-G motif; other site 269796007759 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 269796007760 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 269796007761 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 269796007762 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796007763 P-loop; other site 269796007764 Magnesium ion binding site [ion binding]; other site 269796007765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796007766 active site 269796007767 phosphorylation site [posttranslational modification] 269796007768 intermolecular recognition site; other site 269796007769 dimerization interface [polypeptide binding]; other site 269796007770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796007771 active site 269796007772 phosphorylation site [posttranslational modification] 269796007773 intermolecular recognition site; other site 269796007774 dimerization interface [polypeptide binding]; other site 269796007775 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796007776 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796007777 dimer interface [polypeptide binding]; other site 269796007778 putative CheW interface [polypeptide binding]; other site 269796007779 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 269796007780 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 269796007781 putative NADP binding site [chemical binding]; other site 269796007782 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 269796007783 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 269796007784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796007785 putative substrate translocation pore; other site 269796007786 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796007787 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 269796007788 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269796007789 N-terminal plug; other site 269796007790 ligand-binding site [chemical binding]; other site 269796007791 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 269796007792 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 269796007793 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269796007794 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269796007795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796007796 Walker A/P-loop; other site 269796007797 ATP binding site [chemical binding]; other site 269796007798 Q-loop/lid; other site 269796007799 ABC transporter signature motif; other site 269796007800 Walker B; other site 269796007801 D-loop; other site 269796007802 H-loop/switch region; other site 269796007803 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269796007804 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269796007805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796007806 Walker A/P-loop; other site 269796007807 ATP binding site [chemical binding]; other site 269796007808 Q-loop/lid; other site 269796007809 ABC transporter signature motif; other site 269796007810 Walker B; other site 269796007811 D-loop; other site 269796007812 H-loop/switch region; other site 269796007813 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 269796007814 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 269796007815 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796007816 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796007817 FecR protein; Region: FecR; pfam04773 269796007818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796007819 TPR motif; other site 269796007820 binding surface 269796007821 Tetratricopeptide repeat; Region: TPR_9; pfam13371 269796007822 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl19246 269796007823 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 269796007824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796007825 binding surface 269796007826 TPR motif; other site 269796007827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796007828 TPR motif; other site 269796007829 binding surface 269796007830 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 269796007831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796007832 binding surface 269796007833 TPR motif; other site 269796007834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796007835 TPR motif; other site 269796007836 binding surface 269796007837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796007838 binding surface 269796007839 TPR motif; other site 269796007840 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 269796007841 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 269796007842 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 269796007843 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 269796007844 Probable Catalytic site; other site 269796007845 metal-binding site 269796007846 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796007847 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796007848 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 269796007849 TPR repeat; Region: TPR_11; pfam13414 269796007850 Methyltransferase domain; Region: Methyltransf_24; pfam13578 269796007851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796007852 S-adenosylmethionine binding site [chemical binding]; other site 269796007853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 269796007854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 269796007855 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269796007856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796007857 TPR motif; other site 269796007858 Uncharacterized conserved protein [Function unknown]; Region: COG3025 269796007859 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 269796007860 putative active site [active] 269796007861 putative metal binding residues [ion binding]; other site 269796007862 signature motif; other site 269796007863 putative triphosphate binding site [ion binding]; other site 269796007864 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 269796007865 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 269796007866 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 269796007867 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 269796007868 peptide binding site [polypeptide binding]; other site 269796007869 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 269796007870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796007871 dimer interface [polypeptide binding]; other site 269796007872 conserved gate region; other site 269796007873 putative PBP binding loops; other site 269796007874 ABC-ATPase subunit interface; other site 269796007875 dipeptide transporter; Provisional; Region: PRK10913 269796007876 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 269796007877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796007878 dimer interface [polypeptide binding]; other site 269796007879 conserved gate region; other site 269796007880 putative PBP binding loops; other site 269796007881 ABC-ATPase subunit interface; other site 269796007882 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 269796007883 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796007884 Walker A/P-loop; other site 269796007885 ATP binding site [chemical binding]; other site 269796007886 Q-loop/lid; other site 269796007887 ABC transporter signature motif; other site 269796007888 Walker B; other site 269796007889 D-loop; other site 269796007890 H-loop/switch region; other site 269796007891 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 269796007892 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 269796007893 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796007894 Walker A/P-loop; other site 269796007895 ATP binding site [chemical binding]; other site 269796007896 Q-loop/lid; other site 269796007897 ABC transporter signature motif; other site 269796007898 Walker B; other site 269796007899 D-loop; other site 269796007900 H-loop/switch region; other site 269796007901 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 269796007902 CHASE domain; Region: CHASE; pfam03924 269796007903 PAS domain S-box; Region: sensory_box; TIGR00229 269796007904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796007905 putative active site [active] 269796007906 heme pocket [chemical binding]; other site 269796007907 PAS fold; Region: PAS_4; pfam08448 269796007908 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796007909 putative active site [active] 269796007910 heme pocket [chemical binding]; other site 269796007911 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 269796007912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796007913 putative active site [active] 269796007914 heme pocket [chemical binding]; other site 269796007915 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 269796007916 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796007917 putative active site [active] 269796007918 heme pocket [chemical binding]; other site 269796007919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796007920 dimer interface [polypeptide binding]; other site 269796007921 phosphorylation site [posttranslational modification] 269796007922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796007923 ATP binding site [chemical binding]; other site 269796007924 Mg2+ binding site [ion binding]; other site 269796007925 G-X-G motif; other site 269796007926 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796007927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796007928 active site 269796007929 phosphorylation site [posttranslational modification] 269796007930 intermolecular recognition site; other site 269796007931 dimerization interface [polypeptide binding]; other site 269796007932 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796007933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796007934 active site 269796007935 phosphorylation site [posttranslational modification] 269796007936 intermolecular recognition site; other site 269796007937 dimerization interface [polypeptide binding]; other site 269796007938 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 269796007939 putative binding surface; other site 269796007940 active site 269796007941 methionine sulfoxide reductase A; Provisional; Region: PRK14054 269796007942 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 269796007943 putative catalytic site [active] 269796007944 putative metal binding site [ion binding]; other site 269796007945 putative phosphate binding site [ion binding]; other site 269796007946 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 269796007947 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 269796007948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269796007949 ATP binding site [chemical binding]; other site 269796007950 putative Mg++ binding site [ion binding]; other site 269796007951 helicase superfamily c-terminal domain; Region: HELICc; smart00490 269796007952 Helicase associated domain (HA2); Region: HA2; pfam04408 269796007953 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 269796007954 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269796007955 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796007956 dimerization interface [polypeptide binding]; other site 269796007957 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796007958 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796007959 dimer interface [polypeptide binding]; other site 269796007960 putative CheW interface [polypeptide binding]; other site 269796007961 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796007962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796007963 active site 269796007964 phosphorylation site [posttranslational modification] 269796007965 intermolecular recognition site; other site 269796007966 dimerization interface [polypeptide binding]; other site 269796007967 PAS fold; Region: PAS; pfam00989 269796007968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796007969 putative active site [active] 269796007970 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 269796007971 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 269796007972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269796007973 Coenzyme A binding pocket [chemical binding]; other site 269796007974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 269796007975 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 269796007976 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 269796007977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269796007978 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 269796007979 DNA binding residues [nucleotide binding] 269796007980 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 269796007981 FecR protein; Region: FecR; pfam04773 269796007982 Secretin and TonB N terminus short domain; Region: STN; smart00965 269796007983 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 269796007984 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269796007985 N-terminal plug; other site 269796007986 ligand-binding site [chemical binding]; other site 269796007987 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 269796007988 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 269796007989 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796007990 PAS fold; Region: PAS_3; pfam08447 269796007991 putative active site [active] 269796007992 heme pocket [chemical binding]; other site 269796007993 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 269796007994 diiron binding motif [ion binding]; other site 269796007995 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 269796007996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796007997 putative substrate translocation pore; other site 269796007998 Lipocalin-like domain; Region: Lipocalin_2; cl19222 269796007999 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 269796008000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796008001 dimer interface [polypeptide binding]; other site 269796008002 conserved gate region; other site 269796008003 putative PBP binding loops; other site 269796008004 ABC-ATPase subunit interface; other site 269796008005 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 269796008006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796008007 Walker A/P-loop; other site 269796008008 ATP binding site [chemical binding]; other site 269796008009 Q-loop/lid; other site 269796008010 ABC transporter signature motif; other site 269796008011 Walker B; other site 269796008012 D-loop; other site 269796008013 H-loop/switch region; other site 269796008014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796008015 dimer interface [polypeptide binding]; other site 269796008016 conserved gate region; other site 269796008017 putative PBP binding loops; other site 269796008018 ABC-ATPase subunit interface; other site 269796008019 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 269796008020 Domain of unknown function (DUF4440); Region: DUF4440; pfam14534 269796008021 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 269796008022 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 269796008023 ABC-ATPase subunit interface; other site 269796008024 dimer interface [polypeptide binding]; other site 269796008025 putative PBP binding regions; other site 269796008026 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 269796008027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796008028 Walker A/P-loop; other site 269796008029 ATP binding site [chemical binding]; other site 269796008030 Q-loop/lid; other site 269796008031 ABC transporter signature motif; other site 269796008032 Walker B; other site 269796008033 D-loop; other site 269796008034 H-loop/switch region; other site 269796008035 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 269796008036 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 269796008037 metal binding site [ion binding]; metal-binding site 269796008038 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 269796008039 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 269796008040 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 269796008041 Secretin and TonB N terminus short domain; Region: STN; smart00965 269796008042 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 269796008043 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269796008044 N-terminal plug; other site 269796008045 ligand-binding site [chemical binding]; other site 269796008046 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 269796008047 FecR protein; Region: FecR; pfam04773 269796008048 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 269796008049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269796008050 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269796008051 DNA binding residues [nucleotide binding] 269796008052 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 269796008053 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 269796008054 dimer interface [polypeptide binding]; other site 269796008055 PYR/PP interface [polypeptide binding]; other site 269796008056 TPP binding site [chemical binding]; other site 269796008057 substrate binding site [chemical binding]; other site 269796008058 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 269796008059 Domain of unknown function; Region: EKR; pfam10371 269796008060 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 269796008061 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 269796008062 TPP-binding site [chemical binding]; other site 269796008063 dimer interface [polypeptide binding]; other site 269796008064 OpgC protein; Region: OpgC_C; cl17858 269796008065 ribulose bisphosphate carboxylase; Provisional; Region: PRK13475 269796008066 Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211 269796008067 dimer interface [polypeptide binding]; other site 269796008068 active site 269796008069 catalytic residue [active] 269796008070 metal binding site [ion binding]; metal-binding site 269796008071 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796008072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796008073 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 269796008074 putative dimerization interface [polypeptide binding]; other site 269796008075 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 269796008076 substrate binding site [chemical binding]; other site 269796008077 hexamer interface [polypeptide binding]; other site 269796008078 metal binding site [ion binding]; metal-binding site 269796008079 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 269796008080 AMP binding site [chemical binding]; other site 269796008081 metal binding site [ion binding]; metal-binding site 269796008082 active site 269796008083 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 269796008084 active site 269796008085 transketolase; Reviewed; Region: PRK12753 269796008086 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 269796008087 TPP-binding site [chemical binding]; other site 269796008088 dimer interface [polypeptide binding]; other site 269796008089 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 269796008090 PYR/PP interface [polypeptide binding]; other site 269796008091 dimer interface [polypeptide binding]; other site 269796008092 TPP binding site [chemical binding]; other site 269796008093 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 269796008094 PAS domain; Region: PAS; smart00091 269796008095 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 269796008096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796008097 dimer interface [polypeptide binding]; other site 269796008098 phosphorylation site [posttranslational modification] 269796008099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796008100 ATP binding site [chemical binding]; other site 269796008101 Mg2+ binding site [ion binding]; other site 269796008102 G-X-G motif; other site 269796008103 response regulator PleD; Reviewed; Region: pleD; PRK09581 269796008104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796008105 active site 269796008106 phosphorylation site [posttranslational modification] 269796008107 intermolecular recognition site; other site 269796008108 dimerization interface [polypeptide binding]; other site 269796008109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796008110 putative active site [active] 269796008111 heme pocket [chemical binding]; other site 269796008112 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796008113 putative active site [active] 269796008114 heme pocket [chemical binding]; other site 269796008115 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796008116 metal binding site [ion binding]; metal-binding site 269796008117 active site 269796008118 I-site; other site 269796008119 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796008120 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 269796008121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269796008122 Coenzyme A binding pocket [chemical binding]; other site 269796008123 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 269796008124 DHH family; Region: DHH; pfam01368 269796008125 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 269796008126 putative active site [active] 269796008127 homoserine dehydrogenase; Provisional; Region: PRK06349 269796008128 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 269796008129 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 269796008130 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 269796008131 aminotransferase; Validated; Region: PRK09148 269796008132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269796008133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796008134 homodimer interface [polypeptide binding]; other site 269796008135 catalytic residue [active] 269796008136 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269796008137 ligand binding site [chemical binding]; other site 269796008138 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 269796008139 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 269796008140 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 269796008141 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 269796008142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796008143 dimer interface [polypeptide binding]; other site 269796008144 conserved gate region; other site 269796008145 putative PBP binding loops; other site 269796008146 ABC-ATPase subunit interface; other site 269796008147 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 269796008148 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 269796008149 Walker A/P-loop; other site 269796008150 ATP binding site [chemical binding]; other site 269796008151 Q-loop/lid; other site 269796008152 ABC transporter signature motif; other site 269796008153 Walker B; other site 269796008154 D-loop; other site 269796008155 H-loop/switch region; other site 269796008156 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 269796008157 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 269796008158 trimer interface [polypeptide binding]; other site 269796008159 putative metal binding site [ion binding]; other site 269796008160 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 269796008161 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 269796008162 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 269796008163 aspartate aminotransferase; Provisional; Region: PRK05764 269796008164 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269796008165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796008166 homodimer interface [polypeptide binding]; other site 269796008167 catalytic residue [active] 269796008168 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223 269796008169 Peptidase family M48; Region: Peptidase_M48; cl12018 269796008170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796008171 TPR motif; other site 269796008172 TPR repeat; Region: TPR_11; pfam13414 269796008173 binding surface 269796008174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796008175 binding surface 269796008176 TPR motif; other site 269796008177 LrgA family; Region: LrgA; pfam03788 269796008178 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 269796008179 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 269796008180 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 269796008181 catalytic residues [active] 269796008182 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 269796008183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796008184 non-specific DNA binding site [nucleotide binding]; other site 269796008185 salt bridge; other site 269796008186 sequence-specific DNA binding site [nucleotide binding]; other site 269796008187 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 269796008188 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 269796008189 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 269796008190 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 269796008191 bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840 269796008192 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 269796008193 thiS-thiF/thiG interaction site; other site 269796008194 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 269796008195 ThiS interaction site; other site 269796008196 putative active site [active] 269796008197 tetramer interface [polypeptide binding]; other site 269796008198 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 269796008199 trimer interface [polypeptide binding]; other site 269796008200 active site 269796008201 dimer interface [polypeptide binding]; other site 269796008202 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 269796008203 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 269796008204 carboxyltransferase (CT) interaction site; other site 269796008205 biotinylation site [posttranslational modification]; other site 269796008206 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 269796008207 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269796008208 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 269796008209 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 269796008210 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 269796008211 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 269796008212 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 269796008213 mce related protein; Region: MCE; pfam02470 269796008214 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 269796008215 mce related protein; Region: MCE; pfam02470 269796008216 NADH dehydrogenase; Validated; Region: PRK08183 269796008217 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 269796008218 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 269796008219 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 269796008220 active site 269796008221 dimer interface [polypeptide binding]; other site 269796008222 effector binding site; other site 269796008223 TSCPD domain; Region: TSCPD; pfam12637 269796008224 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796008225 non-specific DNA binding site [nucleotide binding]; other site 269796008226 salt bridge; other site 269796008227 sequence-specific DNA binding site [nucleotide binding]; other site 269796008228 HipA N-terminal domain; Region: Couple_hipA; pfam13657 269796008229 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 269796008230 HipA-like N-terminal domain; Region: HipA_N; pfam07805 269796008231 HipA-like C-terminal domain; Region: HipA_C; pfam07804 269796008232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796008233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796008234 Permease; Region: Permease; pfam02405 269796008235 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 269796008236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796008237 Walker A/P-loop; other site 269796008238 ATP binding site [chemical binding]; other site 269796008239 Q-loop/lid; other site 269796008240 ABC transporter signature motif; other site 269796008241 Walker B; other site 269796008242 D-loop; other site 269796008243 H-loop/switch region; other site 269796008244 mce related protein; Region: MCE; pfam02470 269796008245 Protein of unknown function (DUF330); Region: DUF330; pfam03886 269796008246 Peptidase family M48; Region: Peptidase_M48; pfam01435 269796008247 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796008248 metal binding site [ion binding]; metal-binding site 269796008249 active site 269796008250 I-site; other site 269796008251 WYL domain; Region: WYL; pfam13280 269796008252 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 269796008253 transmembrane helices; other site 269796008254 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 269796008255 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 269796008256 ligand binding site [chemical binding]; other site 269796008257 NAD binding site [chemical binding]; other site 269796008258 tetramer interface [polypeptide binding]; other site 269796008259 catalytic site [active] 269796008260 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 269796008261 L-serine binding site [chemical binding]; other site 269796008262 ACT domain interface; other site 269796008263 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 269796008264 homotrimer interaction site [polypeptide binding]; other site 269796008265 putative active site [active] 269796008266 Protein of unknown function, DUF482; Region: DUF482; pfam04339 269796008267 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 269796008268 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269796008269 HAMP domain; Region: HAMP; pfam00672 269796008270 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796008271 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796008272 dimer interface [polypeptide binding]; other site 269796008273 putative CheW interface [polypeptide binding]; other site 269796008274 CHAP domain; Region: CHAP; cl17642 269796008275 carboxylate-amine ligase; Provisional; Region: PRK13515 269796008276 N-formylglutamate amidohydrolase; Region: FGase; cl01522 269796008277 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 269796008278 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 269796008279 MOFRL family; Region: MOFRL; pfam05161 269796008280 pyruvate kinase; Provisional; Region: PRK06247 269796008281 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 269796008282 domain interfaces; other site 269796008283 active site 269796008284 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 269796008285 dimer interface [polypeptide binding]; other site 269796008286 active site 269796008287 metal binding site [ion binding]; metal-binding site 269796008288 glutathione binding site [chemical binding]; other site 269796008289 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 269796008290 FeoA domain; Region: FeoA; pfam04023 269796008291 FeoA domain; Region: FeoA; pfam04023 269796008292 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 269796008293 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 269796008294 G1 box; other site 269796008295 GTP/Mg2+ binding site [chemical binding]; other site 269796008296 Switch I region; other site 269796008297 G2 box; other site 269796008298 G3 box; other site 269796008299 Switch II region; other site 269796008300 G4 box; other site 269796008301 G5 box; other site 269796008302 Nucleoside recognition; Region: Gate; pfam07670 269796008303 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 269796008304 FeoC like transcriptional regulator; Region: FeoC; pfam09012 269796008305 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 269796008306 PAS fold; Region: PAS_7; pfam12860 269796008307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796008308 putative active site [active] 269796008309 heme pocket [chemical binding]; other site 269796008310 PAS domain; Region: PAS_8; pfam13188 269796008311 PAS fold; Region: PAS_7; pfam12860 269796008312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796008313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796008314 dimer interface [polypeptide binding]; other site 269796008315 phosphorylation site [posttranslational modification] 269796008316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796008317 ATP binding site [chemical binding]; other site 269796008318 Mg2+ binding site [ion binding]; other site 269796008319 G-X-G motif; other site 269796008320 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 269796008321 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 269796008322 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 269796008323 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 269796008324 Walker A/P-loop; other site 269796008325 ATP binding site [chemical binding]; other site 269796008326 Q-loop/lid; other site 269796008327 ABC transporter signature motif; other site 269796008328 Walker B; other site 269796008329 D-loop; other site 269796008330 H-loop/switch region; other site 269796008331 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 269796008332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796008333 dimer interface [polypeptide binding]; other site 269796008334 conserved gate region; other site 269796008335 putative PBP binding loops; other site 269796008336 ABC-ATPase subunit interface; other site 269796008337 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 269796008338 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 269796008339 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 269796008340 Walker A; other site 269796008341 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 269796008342 G4 box; other site 269796008343 G5 box; other site 269796008344 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 269796008345 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 269796008346 active site 269796008347 substrate binding site [chemical binding]; other site 269796008348 coenzyme B12 binding site [chemical binding]; other site 269796008349 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 269796008350 B12 binding site [chemical binding]; other site 269796008351 cobalt ligand [ion binding]; other site 269796008352 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 269796008353 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 269796008354 heterodimer interface [polypeptide binding]; other site 269796008355 substrate interaction site [chemical binding]; other site 269796008356 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 269796008357 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 269796008358 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 269796008359 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 269796008360 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 269796008361 active site 269796008362 metal binding site [ion binding]; metal-binding site 269796008363 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 269796008364 HAMP domain; Region: HAMP; pfam00672 269796008365 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796008366 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796008367 dimer interface [polypeptide binding]; other site 269796008368 putative CheW interface [polypeptide binding]; other site 269796008369 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 269796008370 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 269796008371 active site 269796008372 homotetramer interface [polypeptide binding]; other site 269796008373 Glucokinase; Region: Glucokinase; cl17310 269796008374 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 269796008375 nucleotide binding site [chemical binding]; other site 269796008376 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 269796008377 Methyltransferase domain; Region: Methyltransf_26; pfam13659 269796008378 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 269796008379 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 269796008380 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 269796008381 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 269796008382 tetramer interface [polypeptide binding]; other site 269796008383 heme binding pocket [chemical binding]; other site 269796008384 NADPH binding site [chemical binding]; other site 269796008385 Cupin domain; Region: Cupin_2; cl17218 269796008386 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 269796008387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796008388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796008389 putative substrate translocation pore; other site 269796008390 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796008391 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796008392 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 269796008393 putative ADP-binding pocket [chemical binding]; other site 269796008394 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 269796008395 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796008396 putative ADP-binding pocket [chemical binding]; other site 269796008397 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 269796008398 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 269796008399 active site 269796008400 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 269796008401 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 269796008402 active site 269796008403 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 269796008404 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 269796008405 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 269796008406 G1 box; other site 269796008407 putative GEF interaction site [polypeptide binding]; other site 269796008408 GTP/Mg2+ binding site [chemical binding]; other site 269796008409 Switch I region; other site 269796008410 G2 box; other site 269796008411 G3 box; other site 269796008412 Switch II region; other site 269796008413 G4 box; other site 269796008414 G5 box; other site 269796008415 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 269796008416 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 269796008417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796008418 Walker A/P-loop; other site 269796008419 ATP binding site [chemical binding]; other site 269796008420 Q-loop/lid; other site 269796008421 ABC transporter signature motif; other site 269796008422 Walker B; other site 269796008423 D-loop; other site 269796008424 H-loop/switch region; other site 269796008425 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 269796008426 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 269796008427 ABC-2 type transporter; Region: ABC2_membrane; cl17235 269796008428 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 269796008429 active site residue [active] 269796008430 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 269796008431 Ligand Binding Site [chemical binding]; other site 269796008432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 269796008433 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 269796008434 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 269796008435 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 269796008436 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796008437 FeS/SAM binding site; other site 269796008438 HemN C-terminal domain; Region: HemN_C; pfam06969 269796008439 Hemerythrin; Region: Hemerythrin; cd12107 269796008440 Fe binding site [ion binding]; other site 269796008441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796008442 active site 269796008443 phosphorylation site [posttranslational modification] 269796008444 intermolecular recognition site; other site 269796008445 dimerization interface [polypeptide binding]; other site 269796008446 enoyl-CoA hydratase; Provisional; Region: PRK06127 269796008447 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269796008448 substrate binding site [chemical binding]; other site 269796008449 oxyanion hole (OAH) forming residues; other site 269796008450 trimer interface [polypeptide binding]; other site 269796008451 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269796008452 active site 269796008453 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 269796008454 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 269796008455 substrate-cofactor binding pocket; other site 269796008456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796008457 catalytic residue [active] 269796008458 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 269796008459 catalytic residue [active] 269796008460 Putative AphA-like transcriptional regulator; Region: AphA_like; pfam14557 269796008461 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 269796008462 NMT1/THI5 like; Region: NMT1; pfam09084 269796008463 PAS fold; Region: PAS; pfam00989 269796008464 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796008465 metal binding site [ion binding]; metal-binding site 269796008466 active site 269796008467 I-site; other site 269796008468 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 269796008469 classical (c) SDRs; Region: SDR_c; cd05233 269796008470 NAD(P) binding site [chemical binding]; other site 269796008471 active site 269796008472 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 269796008473 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 269796008474 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 269796008475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 269796008476 Peptidase M15; Region: Peptidase_M15_3; cl01194 269796008477 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 269796008478 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 269796008479 substrate binding pocket [chemical binding]; other site 269796008480 membrane-bound complex binding site; other site 269796008481 hinge residues; other site 269796008482 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796008483 putative active site [active] 269796008484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796008485 heme pocket [chemical binding]; other site 269796008486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796008487 dimer interface [polypeptide binding]; other site 269796008488 phosphorylation site [posttranslational modification] 269796008489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796008490 ATP binding site [chemical binding]; other site 269796008491 Mg2+ binding site [ion binding]; other site 269796008492 G-X-G motif; other site 269796008493 acyl-CoA synthetase; Validated; Region: PRK07638 269796008494 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 269796008495 acyl-activating enzyme (AAE) consensus motif; other site 269796008496 AMP binding site [chemical binding]; other site 269796008497 active site 269796008498 CoA binding site [chemical binding]; other site 269796008499 MarC family integral membrane protein; Region: MarC; cl00919 269796008500 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 269796008501 Transglycosylase; Region: Transgly; pfam00912 269796008502 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 269796008503 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 269796008504 Staphylococcal nuclease homologue; Region: SNase; cl00140 269796008505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796008506 Walker A motif; other site 269796008507 ATP binding site [chemical binding]; other site 269796008508 Walker B motif; other site 269796008509 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 269796008510 AAA domain; Region: AAA_12; pfam13087 269796008511 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 269796008512 additional DNA contacts [nucleotide binding]; other site 269796008513 mismatch recognition site; other site 269796008514 active site 269796008515 zinc binding site [ion binding]; other site 269796008516 DNA intercalation site [nucleotide binding]; other site 269796008517 Putative NADH-flavin reductase [General function prediction only]; Region: COG2910 269796008518 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 269796008519 NAD(P) binding site [chemical binding]; other site 269796008520 active site 269796008521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269796008522 dimerization interface [polypeptide binding]; other site 269796008523 putative DNA binding site [nucleotide binding]; other site 269796008524 putative Zn2+ binding site [ion binding]; other site 269796008525 putative protease; Provisional; Region: PRK15447 269796008526 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 269796008527 SCP-2 sterol transfer family; Region: SCP2; cl01225 269796008528 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 269796008529 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 269796008530 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 269796008531 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 269796008532 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 269796008533 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 269796008534 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 269796008535 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 269796008536 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 269796008537 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 269796008538 flagellin; Reviewed; Region: PRK08869 269796008539 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 269796008540 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 269796008541 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 269796008542 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 269796008543 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 269796008544 Flagellar protein FliS; Region: FliS; cl00654 269796008545 RNA polymerase sigma factor; Reviewed; Region: PRK05602 269796008546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269796008547 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269796008548 DNA binding residues [nucleotide binding] 269796008549 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 269796008550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796008551 putative substrate translocation pore; other site 269796008552 Protein of unknown function, DUF488; Region: DUF488; pfam04343 269796008553 circadian clock protein KaiC; Reviewed; Region: PRK09302 269796008554 KaiC; Region: KaiC; pfam06745 269796008555 Walker A motif; other site 269796008556 ATP binding site [chemical binding]; other site 269796008557 Walker B motif; other site 269796008558 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 269796008559 Walker A motif; other site 269796008560 ATP binding site [chemical binding]; other site 269796008561 Walker B motif; other site 269796008562 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 269796008563 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 269796008564 tetramer interface [polypeptide binding]; other site 269796008565 dimer interface [polypeptide binding]; other site 269796008566 PAS fold; Region: PAS_4; pfam08448 269796008567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796008568 putative active site [active] 269796008569 heme pocket [chemical binding]; other site 269796008570 PAS domain; Region: PAS_9; pfam13426 269796008571 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 269796008572 HWE histidine kinase; Region: HWE_HK; pfam07536 269796008573 Predicted membrane protein [Function unknown]; Region: COG1238 269796008574 Cache domain; Region: Cache_1; pfam02743 269796008575 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796008576 dimerization interface [polypeptide binding]; other site 269796008577 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796008578 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269796008579 dimer interface [polypeptide binding]; other site 269796008580 putative CheW interface [polypeptide binding]; other site 269796008581 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 269796008582 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 269796008583 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 269796008584 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 269796008585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269796008586 active site 269796008587 motif I; other site 269796008588 motif II; other site 269796008589 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 269796008590 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 269796008591 putative active site [active] 269796008592 HAUS augmin-like complex subunit 6 N-terminus; Region: HAUS6_N; pfam14661 269796008593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 269796008594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796008595 S-adenosylmethionine binding site [chemical binding]; other site 269796008596 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 269796008597 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796008598 dimerization interface [polypeptide binding]; other site 269796008599 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796008600 dimer interface [polypeptide binding]; other site 269796008601 putative CheW interface [polypeptide binding]; other site 269796008602 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796008603 metal binding site [ion binding]; metal-binding site 269796008604 active site 269796008605 I-site; other site 269796008606 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 269796008607 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 269796008608 active site 269796008609 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 269796008610 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 269796008611 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 269796008612 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 269796008613 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 269796008614 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl17448 269796008615 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 269796008616 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 269796008617 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 269796008618 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 269796008619 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 269796008620 putative CheA interaction surface; other site 269796008621 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796008622 metal binding site [ion binding]; metal-binding site 269796008623 active site 269796008624 I-site; other site 269796008625 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 269796008626 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 269796008627 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 269796008628 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269796008629 catalytic residue [active] 269796008630 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 269796008631 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 269796008632 FeS assembly ATPase SufC; Region: sufC; TIGR01978 269796008633 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 269796008634 Walker A/P-loop; other site 269796008635 ATP binding site [chemical binding]; other site 269796008636 Q-loop/lid; other site 269796008637 ABC transporter signature motif; other site 269796008638 Walker B; other site 269796008639 D-loop; other site 269796008640 H-loop/switch region; other site 269796008641 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 269796008642 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 269796008643 Transcriptional regulator; Region: Rrf2; cl17282 269796008644 Rrf2 family protein; Region: rrf2_super; TIGR00738 269796008645 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 269796008646 glycogen branching enzyme; Provisional; Region: PRK05402 269796008647 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 269796008648 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 269796008649 active site 269796008650 catalytic site [active] 269796008651 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 269796008652 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 269796008653 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 269796008654 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 269796008655 active site 269796008656 catalytic site [active] 269796008657 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 269796008658 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 269796008659 DEAD-like helicases superfamily; Region: DEXDc; smart00487 269796008660 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 269796008661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796008662 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796008663 metal binding site [ion binding]; metal-binding site 269796008664 active site 269796008665 I-site; other site 269796008666 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 269796008667 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; cl09440 269796008668 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796008669 metal binding site [ion binding]; metal-binding site 269796008670 active site 269796008671 I-site; other site 269796008672 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 269796008673 Uncharacterized conserved protein [Function unknown]; Region: COG2966 269796008674 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 269796008675 Iron permease FTR1 family; Region: FTR1; cl00475 269796008676 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 269796008677 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 269796008678 Imelysin; Region: Peptidase_M75; pfam09375 269796008679 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 269796008680 Imelysin; Region: Peptidase_M75; pfam09375 269796008681 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 269796008682 CHASE4 domain; Region: CHASE4; pfam05228 269796008683 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 269796008684 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796008685 dimerization interface [polypeptide binding]; other site 269796008686 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796008687 metal binding site [ion binding]; metal-binding site 269796008688 active site 269796008689 I-site; other site 269796008690 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796008691 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 269796008692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796008693 active site 269796008694 phosphorylation site [posttranslational modification] 269796008695 intermolecular recognition site; other site 269796008696 dimerization interface [polypeptide binding]; other site 269796008697 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 269796008698 DNA binding residues [nucleotide binding] 269796008699 dimerization interface [polypeptide binding]; other site 269796008700 biofilm formation regulator HmsP; Provisional; Region: PRK11829 269796008701 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796008702 metal binding site [ion binding]; metal-binding site 269796008703 active site 269796008704 I-site; other site 269796008705 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796008706 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 269796008707 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 269796008708 dimer interface [polypeptide binding]; other site 269796008709 active site 269796008710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796008711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796008712 dimer interface [polypeptide binding]; other site 269796008713 phosphorylation site [posttranslational modification] 269796008714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796008715 ATP binding site [chemical binding]; other site 269796008716 Mg2+ binding site [ion binding]; other site 269796008717 G-X-G motif; other site 269796008718 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269796008719 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 269796008720 Ligand Binding Site [chemical binding]; other site 269796008721 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 269796008722 Phosphotransferase enzyme family; Region: APH; pfam01636 269796008723 substrate binding site [chemical binding]; other site 269796008724 Predicted kinase [General function prediction only]; Region: COG0645 269796008725 AAA domain; Region: AAA_33; pfam13671 269796008726 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 269796008727 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796008728 non-specific DNA binding site [nucleotide binding]; other site 269796008729 salt bridge; other site 269796008730 sequence-specific DNA binding site [nucleotide binding]; other site 269796008731 Cupin domain; Region: Cupin_2; pfam07883 269796008732 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269796008733 dimerization interface [polypeptide binding]; other site 269796008734 putative DNA binding site [nucleotide binding]; other site 269796008735 putative Zn2+ binding site [ion binding]; other site 269796008736 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 269796008737 putative active site [active] 269796008738 Zn binding site [ion binding]; other site 269796008739 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 269796008740 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 269796008741 substrate binding pocket [chemical binding]; other site 269796008742 chain length determination region; other site 269796008743 substrate-Mg2+ binding site; other site 269796008744 catalytic residues [active] 269796008745 aspartate-rich region 1; other site 269796008746 active site lid residues [active] 269796008747 aspartate-rich region 2; other site 269796008748 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 269796008749 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 269796008750 TPP-binding site; other site 269796008751 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 269796008752 PYR/PP interface [polypeptide binding]; other site 269796008753 dimer interface [polypeptide binding]; other site 269796008754 TPP binding site [chemical binding]; other site 269796008755 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 269796008756 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 269796008757 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269796008758 RNA binding surface [nucleotide binding]; other site 269796008759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796008760 S-adenosylmethionine binding site [chemical binding]; other site 269796008761 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 269796008762 tandem repeat interface [polypeptide binding]; other site 269796008763 oligomer interface [polypeptide binding]; other site 269796008764 active site residues [active] 269796008765 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 269796008766 tandem repeat interface [polypeptide binding]; other site 269796008767 oligomer interface [polypeptide binding]; other site 269796008768 active site residues [active] 269796008769 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 269796008770 Tetramer interface [polypeptide binding]; other site 269796008771 active site 269796008772 FMN-binding site [chemical binding]; other site 269796008773 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 269796008774 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 269796008775 NAD binding site [chemical binding]; other site 269796008776 homotetramer interface [polypeptide binding]; other site 269796008777 homodimer interface [polypeptide binding]; other site 269796008778 substrate binding site [chemical binding]; other site 269796008779 active site 269796008780 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 269796008781 Transcriptional regulator; Region: Rrf2; cl17282 269796008782 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 269796008783 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 269796008784 HSP70 interaction site [polypeptide binding]; other site 269796008785 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 269796008786 substrate binding site [polypeptide binding]; other site 269796008787 dimer interface [polypeptide binding]; other site 269796008788 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 269796008789 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 269796008790 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 269796008791 Cation efflux family; Region: Cation_efflux; cl00316 269796008792 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 269796008793 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 269796008794 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 269796008795 nucleotide binding site [chemical binding]; other site 269796008796 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 269796008797 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 269796008798 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 269796008799 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 269796008800 Walker A/P-loop; other site 269796008801 ATP binding site [chemical binding]; other site 269796008802 Q-loop/lid; other site 269796008803 ABC transporter signature motif; other site 269796008804 Walker B; other site 269796008805 D-loop; other site 269796008806 H-loop/switch region; other site 269796008807 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 269796008808 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 269796008809 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269796008810 ligand binding site [chemical binding]; other site 269796008811 flexible hinge region; other site 269796008812 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 269796008813 putative switch regulator; other site 269796008814 non-specific DNA interactions [nucleotide binding]; other site 269796008815 DNA binding site [nucleotide binding] 269796008816 sequence specific DNA binding site [nucleotide binding]; other site 269796008817 putative cAMP binding site [chemical binding]; other site 269796008818 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 269796008819 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269796008820 ligand binding site [chemical binding]; other site 269796008821 flexible hinge region; other site 269796008822 putative switch regulator; other site 269796008823 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 269796008824 non-specific DNA interactions [nucleotide binding]; other site 269796008825 DNA binding site [nucleotide binding] 269796008826 sequence specific DNA binding site [nucleotide binding]; other site 269796008827 putative cAMP binding site [chemical binding]; other site 269796008828 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 269796008829 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 269796008830 Methyltransferase domain; Region: Methyltransf_24; pfam13578 269796008831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796008832 binding surface 269796008833 TPR motif; other site 269796008834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796008835 S-adenosylmethionine binding site [chemical binding]; other site 269796008836 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 269796008837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 269796008838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 269796008839 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 269796008840 Putative lysophospholipase; Region: Hydrolase_4; cl19140 269796008841 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 269796008842 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 269796008843 putative active site [active] 269796008844 catalytic site [active] 269796008845 putative metal binding site [ion binding]; other site 269796008846 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 269796008847 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 269796008848 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 269796008849 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 269796008850 FAD dependent oxidoreductase; Region: DAO; pfam01266 269796008851 Glycoside-hydrolase family GH114; Region: Glyco_hydro_114; cl00997 269796008852 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 269796008853 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269796008854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796008855 homodimer interface [polypeptide binding]; other site 269796008856 catalytic residue [active] 269796008857 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 269796008858 Acylphosphatase; Region: Acylphosphatase; cl00551 269796008859 intracellular septation protein A; Reviewed; Region: PRK00259 269796008860 ATP12 chaperone protein; Region: ATP12; cl02228 269796008861 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 269796008862 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 269796008863 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 269796008864 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 269796008865 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269796008866 motif II; other site 269796008867 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 269796008868 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269796008869 RNA binding surface [nucleotide binding]; other site 269796008870 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 269796008871 active site 269796008872 recombination factor protein RarA; Reviewed; Region: PRK13342 269796008873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796008874 Walker A motif; other site 269796008875 ATP binding site [chemical binding]; other site 269796008876 Walker B motif; other site 269796008877 arginine finger; other site 269796008878 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 269796008879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796008880 dimerization interface [polypeptide binding]; other site 269796008881 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796008882 metal binding site [ion binding]; metal-binding site 269796008883 active site 269796008884 I-site; other site 269796008885 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 269796008886 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 269796008887 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269796008888 protein binding site [polypeptide binding]; other site 269796008889 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269796008890 protein binding site [polypeptide binding]; other site 269796008891 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 269796008892 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 269796008893 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 269796008894 alphaNTD - beta interaction site [polypeptide binding]; other site 269796008895 alphaNTD homodimer interface [polypeptide binding]; other site 269796008896 alphaNTD - beta' interaction site [polypeptide binding]; other site 269796008897 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 269796008898 30S ribosomal protein S11; Validated; Region: PRK05309 269796008899 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 269796008900 adenylate kinase; Reviewed; Region: adk; PRK00279 269796008901 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 269796008902 AMP-binding site [chemical binding]; other site 269796008903 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 269796008904 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 269796008905 SecY translocase; Region: SecY; pfam00344 269796008906 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 269796008907 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 269796008908 23S rRNA binding site [nucleotide binding]; other site 269796008909 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 269796008910 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 269796008911 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 269796008912 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 269796008913 23S rRNA interface [nucleotide binding]; other site 269796008914 L21e interface [polypeptide binding]; other site 269796008915 5S rRNA interface [nucleotide binding]; other site 269796008916 L27 interface [polypeptide binding]; other site 269796008917 L5 interface [polypeptide binding]; other site 269796008918 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 269796008919 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 269796008920 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 269796008921 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 269796008922 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 269796008923 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 269796008924 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 269796008925 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 269796008926 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 269796008927 RNA binding site [nucleotide binding]; other site 269796008928 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 269796008929 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 269796008930 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 269796008931 23S rRNA interface [nucleotide binding]; other site 269796008932 putative translocon interaction site; other site 269796008933 signal recognition particle (SRP54) interaction site; other site 269796008934 L23 interface [polypeptide binding]; other site 269796008935 trigger factor interaction site; other site 269796008936 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 269796008937 23S rRNA interface [nucleotide binding]; other site 269796008938 5S rRNA interface [nucleotide binding]; other site 269796008939 putative antibiotic binding site [chemical binding]; other site 269796008940 L25 interface [polypeptide binding]; other site 269796008941 L27 interface [polypeptide binding]; other site 269796008942 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 269796008943 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 269796008944 G-X-X-G motif; other site 269796008945 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 269796008946 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 269796008947 putative translocon binding site; other site 269796008948 protein-rRNA interface [nucleotide binding]; other site 269796008949 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 269796008950 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 269796008951 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 269796008952 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 269796008953 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 269796008954 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 269796008955 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 269796008956 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 269796008957 elongation factor Tu; Reviewed; Region: PRK00049 269796008958 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 269796008959 G1 box; other site 269796008960 GEF interaction site [polypeptide binding]; other site 269796008961 GTP/Mg2+ binding site [chemical binding]; other site 269796008962 Switch I region; other site 269796008963 G2 box; other site 269796008964 G3 box; other site 269796008965 Switch II region; other site 269796008966 G4 box; other site 269796008967 G5 box; other site 269796008968 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 269796008969 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 269796008970 Antibiotic Binding Site [chemical binding]; other site 269796008971 elongation factor G; Reviewed; Region: PRK00007 269796008972 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 269796008973 G1 box; other site 269796008974 putative GEF interaction site [polypeptide binding]; other site 269796008975 GTP/Mg2+ binding site [chemical binding]; other site 269796008976 Switch I region; other site 269796008977 G2 box; other site 269796008978 G3 box; other site 269796008979 Switch II region; other site 269796008980 G4 box; other site 269796008981 G5 box; other site 269796008982 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 269796008983 Elongation Factor G, domain II; Region: EFG_II; pfam14492 269796008984 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 269796008985 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 269796008986 30S ribosomal protein S7; Validated; Region: PRK05302 269796008987 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 269796008988 S17 interaction site [polypeptide binding]; other site 269796008989 S8 interaction site; other site 269796008990 16S rRNA interaction site [nucleotide binding]; other site 269796008991 streptomycin interaction site [chemical binding]; other site 269796008992 23S rRNA interaction site [nucleotide binding]; other site 269796008993 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 269796008994 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 269796008995 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 269796008996 beta and beta' interface [polypeptide binding]; other site 269796008997 beta' and sigma factor interface [polypeptide binding]; other site 269796008998 Zn-binding [ion binding]; other site 269796008999 active site region [active] 269796009000 catalytic site [active] 269796009001 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 269796009002 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 269796009003 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 269796009004 G-loop; other site 269796009005 DNA binding site [nucleotide binding] 269796009006 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 269796009007 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 269796009008 RPB12 interaction site [polypeptide binding]; other site 269796009009 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 269796009010 RPB1 interaction site [polypeptide binding]; other site 269796009011 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 269796009012 RPB10 interaction site [polypeptide binding]; other site 269796009013 RPB11 interaction site [polypeptide binding]; other site 269796009014 RPB3 interaction site [polypeptide binding]; other site 269796009015 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 269796009016 core dimer interface [polypeptide binding]; other site 269796009017 peripheral dimer interface [polypeptide binding]; other site 269796009018 L10 interface [polypeptide binding]; other site 269796009019 L11 interface [polypeptide binding]; other site 269796009020 putative EF-Tu interaction site [polypeptide binding]; other site 269796009021 putative EF-G interaction site [polypeptide binding]; other site 269796009022 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 269796009023 23S rRNA interface [nucleotide binding]; other site 269796009024 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 269796009025 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 269796009026 mRNA/rRNA interface [nucleotide binding]; other site 269796009027 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 269796009028 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 269796009029 23S rRNA interface [nucleotide binding]; other site 269796009030 L7/L12 interface [polypeptide binding]; other site 269796009031 putative thiostrepton binding site; other site 269796009032 L25 interface [polypeptide binding]; other site 269796009033 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 269796009034 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 269796009035 putative homodimer interface [polypeptide binding]; other site 269796009036 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 269796009037 heterodimer interface [polypeptide binding]; other site 269796009038 homodimer interface [polypeptide binding]; other site 269796009039 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 269796009040 elongation factor Tu; Reviewed; Region: PRK00049 269796009041 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 269796009042 G1 box; other site 269796009043 GEF interaction site [polypeptide binding]; other site 269796009044 GTP/Mg2+ binding site [chemical binding]; other site 269796009045 Switch I region; other site 269796009046 G2 box; other site 269796009047 G3 box; other site 269796009048 Switch II region; other site 269796009049 G4 box; other site 269796009050 G5 box; other site 269796009051 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 269796009052 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 269796009053 Antibiotic Binding Site [chemical binding]; other site 269796009054 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 269796009055 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 269796009056 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 269796009057 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 269796009058 Putative lysophospholipase; Region: Hydrolase_4; cl19140 269796009059 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 269796009060 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 269796009061 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 269796009062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796009063 ATP binding site [chemical binding]; other site 269796009064 Mg2+ binding site [ion binding]; other site 269796009065 G-X-G motif; other site 269796009066 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 269796009067 anchoring element; other site 269796009068 dimer interface [polypeptide binding]; other site 269796009069 ATP binding site [chemical binding]; other site 269796009070 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 269796009071 active site 269796009072 metal binding site [ion binding]; metal-binding site 269796009073 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 269796009074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269796009075 Coenzyme A binding pocket [chemical binding]; other site 269796009076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796009077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796009078 Restriction endonuclease; Region: Mrr_cat; cl19295 269796009079 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 269796009080 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 269796009081 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 269796009082 catalytic triad [active] 269796009083 dimer interface [polypeptide binding]; other site 269796009084 conserved cis-peptide bond; other site 269796009085 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 269796009086 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 269796009087 ATP binding site [chemical binding]; other site 269796009088 Mg++ binding site [ion binding]; other site 269796009089 motif III; other site 269796009090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269796009091 nucleotide binding region [chemical binding]; other site 269796009092 ATP-binding site [chemical binding]; other site 269796009093 Protein of unknown function (DUF1800); Region: DUF1800; cl19889 269796009094 indolepyruvate/phenylpyruvate decarboxylase, Azospirillum family; Region: indol_phenyl_DC; TIGR03394 269796009095 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 269796009096 dimer interface [polypeptide binding]; other site 269796009097 PYR/PP interface [polypeptide binding]; other site 269796009098 TPP binding site [chemical binding]; other site 269796009099 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 269796009100 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 269796009101 TPP-binding site [chemical binding]; other site 269796009102 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269796009103 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 269796009104 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 269796009105 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 269796009106 dimer interface [polypeptide binding]; other site 269796009107 PYR/PP interface [polypeptide binding]; other site 269796009108 TPP binding site [chemical binding]; other site 269796009109 substrate binding site [chemical binding]; other site 269796009110 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 269796009111 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 269796009112 TPP-binding site [chemical binding]; other site 269796009113 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 269796009114 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 269796009115 diiron binding motif [ion binding]; other site 269796009116 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 269796009117 Predicted esterase [General function prediction only]; Region: COG0400 269796009118 PAS domain; Region: PAS_9; pfam13426 269796009119 PAS fold; Region: PAS_7; pfam12860 269796009120 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 269796009121 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796009122 putative active site [active] 269796009123 heme pocket [chemical binding]; other site 269796009124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796009125 dimer interface [polypeptide binding]; other site 269796009126 phosphorylation site [posttranslational modification] 269796009127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796009128 ATP binding site [chemical binding]; other site 269796009129 Mg2+ binding site [ion binding]; other site 269796009130 G-X-G motif; other site 269796009131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796009132 active site 269796009133 phosphorylation site [posttranslational modification] 269796009134 intermolecular recognition site; other site 269796009135 dimerization interface [polypeptide binding]; other site 269796009136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796009137 active site 269796009138 phosphorylation site [posttranslational modification] 269796009139 intermolecular recognition site; other site 269796009140 dimerization interface [polypeptide binding]; other site 269796009141 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 269796009142 NnrU protein; Region: NnrU; pfam07298 269796009143 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 269796009144 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 269796009145 HerA helicase [Replication, recombination, and repair]; Region: COG0433 269796009146 AAA ATPase domain; Region: AAA_16; pfam13191 269796009147 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 269796009148 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269796009149 active site 269796009150 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 269796009151 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 269796009152 NADP binding site [chemical binding]; other site 269796009153 active site 269796009154 putative substrate binding site [chemical binding]; other site 269796009155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796009156 S-adenosylmethionine binding site [chemical binding]; other site 269796009157 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796009158 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 269796009159 Methyltransferase domain; Region: Methyltransf_23; pfam13489 269796009160 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 269796009161 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269796009162 active site 269796009163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796009164 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796009165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796009166 S-adenosylmethionine binding site [chemical binding]; other site 269796009167 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796009168 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796009169 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 269796009170 active site 269796009171 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 269796009172 homodimer interface [polypeptide binding]; other site 269796009173 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 269796009174 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 269796009175 NAD(P) binding site [chemical binding]; other site 269796009176 homodimer interface [polypeptide binding]; other site 269796009177 substrate binding site [chemical binding]; other site 269796009178 active site 269796009179 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796009180 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796009181 FeS/SAM binding site; other site 269796009182 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 269796009183 WbqC-like protein family; Region: WbqC; pfam08889 269796009184 Methyltransferase domain; Region: Methyltransf_24; pfam13578 269796009185 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 269796009186 inhibitor-cofactor binding pocket; inhibition site 269796009187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796009188 catalytic residue [active] 269796009189 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 269796009190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269796009191 NAD(P) binding site [chemical binding]; other site 269796009192 active site 269796009193 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 269796009194 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 269796009195 Walker A/P-loop; other site 269796009196 ATP binding site [chemical binding]; other site 269796009197 Q-loop/lid; other site 269796009198 ABC transporter signature motif; other site 269796009199 Walker B; other site 269796009200 D-loop; other site 269796009201 H-loop/switch region; other site 269796009202 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 269796009203 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 269796009204 FtsX-like permease family; Region: FtsX; pfam02687 269796009205 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 269796009206 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269796009207 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796009208 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 269796009209 PAS fold; Region: PAS; pfam00989 269796009210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 269796009211 Histidine kinase; Region: HisKA_2; pfam07568 269796009212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796009213 ATP binding site [chemical binding]; other site 269796009214 Mg2+ binding site [ion binding]; other site 269796009215 G-X-G motif; other site 269796009216 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 269796009217 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 269796009218 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 269796009219 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 269796009220 DNA-binding site [nucleotide binding]; DNA binding site 269796009221 RNA-binding motif; other site 269796009222 GAF domain; Region: GAF; pfam01590 269796009223 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796009224 dimerization interface [polypeptide binding]; other site 269796009225 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796009226 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796009227 dimer interface [polypeptide binding]; other site 269796009228 putative CheW interface [polypeptide binding]; other site 269796009229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796009230 active site 269796009231 phosphorylation site [posttranslational modification] 269796009232 intermolecular recognition site; other site 269796009233 dimerization interface [polypeptide binding]; other site 269796009234 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 269796009235 cubane metal cluster [ion binding]; other site 269796009236 hybrid metal cluster; other site 269796009237 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 269796009238 PAS domain S-box; Region: sensory_box; TIGR00229 269796009239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796009240 putative active site [active] 269796009241 heme pocket [chemical binding]; other site 269796009242 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796009243 metal binding site [ion binding]; metal-binding site 269796009244 active site 269796009245 I-site; other site 269796009246 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796009247 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 269796009248 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 269796009249 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269796009250 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 269796009251 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 269796009252 Peptidase_C39 like family; Region: DUF3335; pfam11814 269796009253 Domain of unknown function (DUF329); Region: DUF329; pfam03884 269796009254 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 269796009255 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 269796009256 homodimer interface [polypeptide binding]; other site 269796009257 oligonucleotide binding site [chemical binding]; other site 269796009258 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 269796009259 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 269796009260 active site 269796009261 dimer interface [polypeptide binding]; other site 269796009262 Low molecular weight phosphatase family; Region: LMWPc; cd00115 269796009263 active site 269796009264 hypothetical protein; Provisional; Region: PRK02853 269796009265 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 269796009266 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 269796009267 NAD binding site [chemical binding]; other site 269796009268 dimerization interface [polypeptide binding]; other site 269796009269 product binding site; other site 269796009270 substrate binding site [chemical binding]; other site 269796009271 zinc binding site [ion binding]; other site 269796009272 catalytic residues [active] 269796009273 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 269796009274 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 269796009275 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796009276 dimerization interface [polypeptide binding]; other site 269796009277 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796009278 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796009279 dimer interface [polypeptide binding]; other site 269796009280 putative CheW interface [polypeptide binding]; other site 269796009281 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 269796009282 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 269796009283 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 269796009284 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 269796009285 putative active site pocket [active] 269796009286 dimerization interface [polypeptide binding]; other site 269796009287 putative catalytic residue [active] 269796009288 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796009289 EamA-like transporter family; Region: EamA; pfam00892 269796009290 EamA-like transporter family; Region: EamA; pfam00892 269796009291 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 269796009292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796009293 salt bridge; other site 269796009294 non-specific DNA binding site [nucleotide binding]; other site 269796009295 sequence-specific DNA binding site [nucleotide binding]; other site 269796009296 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 269796009297 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 269796009298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796009299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796009300 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 269796009301 dimerization interface [polypeptide binding]; other site 269796009302 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 269796009303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416 269796009304 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 269796009305 putative ligand binding site [chemical binding]; other site 269796009306 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 269796009307 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 269796009308 Walker A/P-loop; other site 269796009309 ATP binding site [chemical binding]; other site 269796009310 Q-loop/lid; other site 269796009311 ABC transporter signature motif; other site 269796009312 Walker B; other site 269796009313 D-loop; other site 269796009314 H-loop/switch region; other site 269796009315 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 269796009316 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 269796009317 TM-ABC transporter signature motif; other site 269796009318 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 269796009319 TM-ABC transporter signature motif; other site 269796009320 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 269796009321 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 269796009322 active site 269796009323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796009324 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796009325 putative substrate translocation pore; other site 269796009326 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 269796009327 Ligand Binding Site [chemical binding]; other site 269796009328 Transcriptional regulators [Transcription]; Region: MarR; COG1846 269796009329 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 269796009330 putative DNA binding site [nucleotide binding]; other site 269796009331 putative Zn2+ binding site [ion binding]; other site 269796009332 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 269796009333 trimer interface [polypeptide binding]; other site 269796009334 active site 269796009335 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 269796009336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 269796009337 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 269796009338 trimer interface [polypeptide binding]; other site 269796009339 active site 269796009340 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 269796009341 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 269796009342 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 269796009343 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 269796009344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 269796009345 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 269796009346 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 269796009347 catalytic residues [active] 269796009348 Cytochrome c; Region: Cytochrom_C; cl11414 269796009349 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 269796009350 catalytic residues [active] 269796009351 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 269796009352 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 269796009353 Walker A/P-loop; other site 269796009354 ATP binding site [chemical binding]; other site 269796009355 Q-loop/lid; other site 269796009356 ABC transporter signature motif; other site 269796009357 Walker B; other site 269796009358 D-loop; other site 269796009359 H-loop/switch region; other site 269796009360 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 269796009361 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 269796009362 FtsX-like permease family; Region: FtsX; pfam02687 269796009363 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 269796009364 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 269796009365 FtsX-like permease family; Region: FtsX; pfam02687 269796009366 Predicted integral membrane protein [Function unknown]; Region: COG5617 269796009367 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 269796009368 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 269796009369 Fe2+ transport protein; Region: Iron_transport; pfam10634 269796009370 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 269796009371 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 269796009372 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 269796009373 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 269796009374 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796009375 FeS/SAM binding site; other site 269796009376 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 269796009377 GTP binding site; other site 269796009378 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 269796009379 trimer interface [polypeptide binding]; other site 269796009380 dimer interface [polypeptide binding]; other site 269796009381 putative active site [active] 269796009382 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 269796009383 MoaE interaction surface [polypeptide binding]; other site 269796009384 MoeB interaction surface [polypeptide binding]; other site 269796009385 thiocarboxylated glycine; other site 269796009386 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 269796009387 MoaE homodimer interface [polypeptide binding]; other site 269796009388 MoaD interaction [polypeptide binding]; other site 269796009389 active site residues [active] 269796009390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796009391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796009392 Phasin protein; Region: Phasin_2; pfam09361 269796009393 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 269796009394 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 269796009395 motif 1; other site 269796009396 active site 269796009397 motif 2; other site 269796009398 motif 3; other site 269796009399 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 269796009400 recombinase A; Provisional; Region: recA; PRK09354 269796009401 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 269796009402 hexamer interface [polypeptide binding]; other site 269796009403 Walker A motif; other site 269796009404 ATP binding site [chemical binding]; other site 269796009405 Walker B motif; other site 269796009406 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 269796009407 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 269796009408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796009409 histidine kinase; Provisional; Region: PRK13557 269796009410 putative active site [active] 269796009411 heme pocket [chemical binding]; other site 269796009412 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796009413 dimer interface [polypeptide binding]; other site 269796009414 phosphorylation site [posttranslational modification] 269796009415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796009416 ATP binding site [chemical binding]; other site 269796009417 Mg2+ binding site [ion binding]; other site 269796009418 G-X-G motif; other site 269796009419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796009420 active site 269796009421 phosphorylation site [posttranslational modification] 269796009422 intermolecular recognition site; other site 269796009423 dimerization interface [polypeptide binding]; other site 269796009424 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 269796009425 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 269796009426 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 269796009427 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 269796009428 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 269796009429 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 269796009430 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 269796009431 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 269796009432 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 269796009433 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 269796009434 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 269796009435 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 269796009436 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 269796009437 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 269796009438 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 269796009439 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 269796009440 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 269796009441 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796009442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796009443 active site 269796009444 phosphorylation site [posttranslational modification] 269796009445 intermolecular recognition site; other site 269796009446 dimerization interface [polypeptide binding]; other site 269796009447 Uncharacterized conserved protein [Function unknown]; Region: COG3334 269796009448 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 269796009449 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 269796009450 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 269796009451 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 269796009452 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 269796009453 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 269796009454 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 269796009455 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 269796009456 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 269796009457 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 269796009458 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 269796009459 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 269796009460 Flagellar protein FlaF; Region: FlaF; cl11454 269796009461 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 269796009462 flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787 269796009463 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 269796009464 Rod binding protein; Region: Rod-binding; cl01626 269796009465 FlgN protein; Region: FlgN; pfam05130 269796009466 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 269796009467 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 269796009468 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 269796009469 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 269796009470 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 269796009471 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 269796009472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796009473 TPR motif; other site 269796009474 binding surface 269796009475 TPR repeat; Region: TPR_11; pfam13414 269796009476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796009477 TPR motif; other site 269796009478 binding surface 269796009479 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269796009480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796009481 binding surface 269796009482 TPR motif; other site 269796009483 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 269796009484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796009485 TPR motif; other site 269796009486 binding surface 269796009487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796009488 binding surface 269796009489 TPR motif; other site 269796009490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796009491 binding surface 269796009492 TPR motif; other site 269796009493 Tetratricopeptide repeat; Region: TPR_19; pfam14559 269796009494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796009495 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269796009496 TPR motif; other site 269796009497 binding surface 269796009498 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 269796009499 Flagellar protein FlaF; Region: FlaF; pfam07309 269796009500 Flagellar protein FlbT; Region: FlbT; pfam07378 269796009501 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 269796009502 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 269796009503 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 269796009504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796009505 TPR motif; other site 269796009506 TPR repeat; Region: TPR_11; pfam13414 269796009507 binding surface 269796009508 TPR repeat; Region: TPR_11; pfam13414 269796009509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796009510 binding surface 269796009511 TPR motif; other site 269796009512 Tetratricopeptide repeat; Region: TPR_19; pfam14559 269796009513 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 269796009514 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 269796009515 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269796009516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 269796009517 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 269796009518 Putative lysophospholipase; Region: Hydrolase_4; cl19140 269796009519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796009520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796009521 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 269796009522 EF-hand domain pair; Region: EF-hand_7; pfam13499 269796009523 Ca2+ binding site [ion binding]; other site 269796009524 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 269796009525 EF-hand domain pair; Region: EF-hand_7; pfam13499 269796009526 Ca2+ binding site [ion binding]; other site 269796009527 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 269796009528 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 269796009529 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 269796009530 active site 269796009531 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 269796009532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796009533 S-adenosylmethionine binding site [chemical binding]; other site 269796009534 ornithine cyclodeaminase; Validated; Region: PRK06141 269796009535 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 269796009536 HAMP domain; Region: HAMP; pfam00672 269796009537 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796009538 metal binding site [ion binding]; metal-binding site 269796009539 active site 269796009540 I-site; other site 269796009541 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 269796009542 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 269796009543 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 269796009544 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 269796009545 Transporter associated domain; Region: CorC_HlyC; smart01091 269796009546 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 269796009547 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 269796009548 metal binding site [ion binding]; metal-binding site 269796009549 putative dimer interface [polypeptide binding]; other site 269796009550 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 269796009551 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems; Region: PBP1_ABC_ligand_binding_like_14; cd06349 269796009552 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 269796009553 putative ligand binding site [chemical binding]; other site 269796009554 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 269796009555 FAD dependent oxidoreductase; Region: DAO; pfam01266 269796009556 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796009557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796009558 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 269796009559 dimerization interface [polypeptide binding]; other site 269796009560 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 269796009561 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 269796009562 active site 269796009563 catalytic tetrad [active] 269796009564 threonine dehydratase; Provisional; Region: PRK07334 269796009565 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 269796009566 tetramer interface [polypeptide binding]; other site 269796009567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796009568 catalytic residue [active] 269796009569 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 269796009570 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 269796009571 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 269796009572 Predicted integral membrane protein [Function unknown]; Region: COG0392 269796009573 Uncharacterized conserved protein [Function unknown]; Region: COG2898 269796009574 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 269796009575 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 269796009576 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 269796009577 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 269796009578 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 269796009579 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 269796009580 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 269796009581 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269796009582 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 269796009583 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269796009584 DNA binding residues [nucleotide binding] 269796009585 DNA primase, catalytic core; Region: dnaG; TIGR01391 269796009586 CHC2 zinc finger; Region: zf-CHC2; cl17510 269796009587 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 269796009588 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 269796009589 active site 269796009590 metal binding site [ion binding]; metal-binding site 269796009591 interdomain interaction site; other site 269796009592 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 269796009593 Yqey-like protein; Region: YqeY; cl17540 269796009594 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 269796009595 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 269796009596 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 269796009597 catalytic site [active] 269796009598 subunit interface [polypeptide binding]; other site 269796009599 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 269796009600 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269796009601 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269796009602 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 269796009603 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269796009604 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269796009605 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 269796009606 IMP binding site; other site 269796009607 dimer interface [polypeptide binding]; other site 269796009608 interdomain contacts; other site 269796009609 partial ornithine binding site; other site 269796009610 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 269796009611 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 269796009612 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 269796009613 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 269796009614 RES domain; Region: RES; smart00953 269796009615 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 269796009616 ABC-ATPase subunit interface; other site 269796009617 dimer interface [polypeptide binding]; other site 269796009618 putative PBP binding regions; other site 269796009619 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 269796009620 ABC-ATPase subunit interface; other site 269796009621 dimer interface [polypeptide binding]; other site 269796009622 putative PBP binding regions; other site 269796009623 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 269796009624 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 269796009625 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 269796009626 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 269796009627 metal binding site [ion binding]; metal-binding site 269796009628 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 269796009629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269796009630 putative DNA binding site [nucleotide binding]; other site 269796009631 putative Zn2+ binding site [ion binding]; other site 269796009632 AsnC family; Region: AsnC_trans_reg; pfam01037 269796009633 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 269796009634 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 269796009635 decamer (pentamer of dimers) interface [polypeptide binding]; other site 269796009636 catalytic triad [active] 269796009637 dimer interface [polypeptide binding]; other site 269796009638 peroxidatic and resolving cysteines [active] 269796009639 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 269796009640 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796009641 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269796009642 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796009643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796009644 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 269796009645 putative effector binding pocket; other site 269796009646 dimerization interface [polypeptide binding]; other site 269796009647 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796009648 EamA-like transporter family; Region: EamA; pfam00892 269796009649 EamA-like transporter family; Region: EamA; pfam00892 269796009650 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 269796009651 nucleotide binding site/active site [active] 269796009652 HIT family signature motif; other site 269796009653 catalytic residue [active] 269796009654 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 269796009655 DNA photolyase; Region: DNA_photolyase; pfam00875 269796009656 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 269796009657 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 269796009658 Transposase, Mutator family; Region: Transposase_mut; cl19537 269796009659 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796009660 EamA-like transporter family; Region: EamA; pfam00892 269796009661 EamA-like transporter family; Region: EamA; pfam00892 269796009662 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 269796009663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269796009664 putative DNA binding site [nucleotide binding]; other site 269796009665 putative Zn2+ binding site [ion binding]; other site 269796009666 AsnC family; Region: AsnC_trans_reg; pfam01037 269796009667 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 269796009668 anti sigma factor interaction site; other site 269796009669 regulatory phosphorylation site [posttranslational modification]; other site 269796009670 Permease; Region: Permease; pfam02405 269796009671 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 269796009672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796009673 Walker A/P-loop; other site 269796009674 ATP binding site [chemical binding]; other site 269796009675 Q-loop/lid; other site 269796009676 ABC transporter signature motif; other site 269796009677 Walker B; other site 269796009678 D-loop; other site 269796009679 H-loop/switch region; other site 269796009680 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 269796009681 mce related protein; Region: MCE; pfam02470 269796009682 Protein of unknown function (DUF330); Region: DUF330; cl01135 269796009683 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 269796009684 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796009685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796009686 active site 269796009687 phosphorylation site [posttranslational modification] 269796009688 intermolecular recognition site; other site 269796009689 dimerization interface [polypeptide binding]; other site 269796009690 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269796009691 DNA binding site [nucleotide binding] 269796009692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796009693 HAMP domain; Region: HAMP; pfam00672 269796009694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796009695 dimer interface [polypeptide binding]; other site 269796009696 phosphorylation site [posttranslational modification] 269796009697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796009698 ATP binding site [chemical binding]; other site 269796009699 Mg2+ binding site [ion binding]; other site 269796009700 G-X-G motif; other site 269796009701 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 269796009702 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 269796009703 Uncharacterized protein conserved in bacteria (DUF2321); Region: DUF2321; pfam10083 269796009704 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 269796009705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796009706 binding surface 269796009707 TPR motif; other site 269796009708 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 269796009709 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 269796009710 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796009711 TPR repeat; Region: TPR_11; pfam13414 269796009712 binding surface 269796009713 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796009714 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796009715 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796009716 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 269796009717 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 269796009718 active site 269796009719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796009720 H+ Antiporter protein; Region: 2A0121; TIGR00900 269796009721 putative substrate translocation pore; other site 269796009722 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 269796009723 Outer membrane efflux protein; Region: OEP; pfam02321 269796009724 Outer membrane efflux protein; Region: OEP; pfam02321 269796009725 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 269796009726 MMPL family; Region: MMPL; cl14618 269796009727 MMPL family; Region: MMPL; cl14618 269796009728 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 269796009729 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269796009730 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796009731 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796009732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796009733 active site 269796009734 phosphorylation site [posttranslational modification] 269796009735 intermolecular recognition site; other site 269796009736 dimerization interface [polypeptide binding]; other site 269796009737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269796009738 DNA binding site [nucleotide binding] 269796009739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796009740 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796009741 dimerization interface [polypeptide binding]; other site 269796009742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796009743 dimer interface [polypeptide binding]; other site 269796009744 phosphorylation site [posttranslational modification] 269796009745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796009746 ATP binding site [chemical binding]; other site 269796009747 Mg2+ binding site [ion binding]; other site 269796009748 G-X-G motif; other site 269796009749 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 269796009750 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 269796009751 hinge; other site 269796009752 active site 269796009753 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796009754 PAS fold; Region: PAS_4; pfam08448 269796009755 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796009756 putative active site [active] 269796009757 heme pocket [chemical binding]; other site 269796009758 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 269796009759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796009760 putative active site [active] 269796009761 heme pocket [chemical binding]; other site 269796009762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796009763 dimer interface [polypeptide binding]; other site 269796009764 phosphorylation site [posttranslational modification] 269796009765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796009766 ATP binding site [chemical binding]; other site 269796009767 Mg2+ binding site [ion binding]; other site 269796009768 G-X-G motif; other site 269796009769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796009770 active site 269796009771 phosphorylation site [posttranslational modification] 269796009772 intermolecular recognition site; other site 269796009773 dimerization interface [polypeptide binding]; other site 269796009774 dihydroorotase; Validated; Region: PRK09060 269796009775 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 269796009776 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 269796009777 active site 269796009778 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 269796009779 active site 269796009780 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 269796009781 dimer interface [polypeptide binding]; other site 269796009782 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 269796009783 Ligand Binding Site [chemical binding]; other site 269796009784 Molecular Tunnel; other site 269796009785 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796009786 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 269796009787 putative ADP-binding pocket [chemical binding]; other site 269796009788 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796009789 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796009790 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 269796009791 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 269796009792 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 269796009793 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 269796009794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 269796009795 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269796009796 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269796009797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796009798 Walker A/P-loop; other site 269796009799 ATP binding site [chemical binding]; other site 269796009800 Q-loop/lid; other site 269796009801 ABC transporter signature motif; other site 269796009802 Walker B; other site 269796009803 D-loop; other site 269796009804 H-loop/switch region; other site 269796009805 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 269796009806 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796009807 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 269796009808 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 269796009809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796009810 ATP binding site [chemical binding]; other site 269796009811 Mg2+ binding site [ion binding]; other site 269796009812 G-X-G motif; other site 269796009813 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 269796009814 ATP binding site [chemical binding]; other site 269796009815 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 269796009816 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 269796009817 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 269796009818 active site 269796009819 dimer interface [polypeptide binding]; other site 269796009820 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 269796009821 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 269796009822 dimer interface [polypeptide binding]; other site 269796009823 active site 269796009824 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 269796009825 putative active site [active] 269796009826 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 269796009827 substrate binding pocket [chemical binding]; other site 269796009828 chain length determination region; other site 269796009829 substrate-Mg2+ binding site; other site 269796009830 catalytic residues [active] 269796009831 aspartate-rich region 1; other site 269796009832 active site lid residues [active] 269796009833 aspartate-rich region 2; other site 269796009834 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 269796009835 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 269796009836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796009837 S-adenosylmethionine binding site [chemical binding]; other site 269796009838 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 269796009839 dimer interface [polypeptide binding]; other site 269796009840 motif 1; other site 269796009841 active site 269796009842 motif 2; other site 269796009843 motif 3; other site 269796009844 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 269796009845 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 269796009846 pyruvate phosphate dikinase; Provisional; Region: PRK09279 269796009847 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 269796009848 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 269796009849 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 269796009850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796009851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796009852 putative substrate translocation pore; other site 269796009853 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 269796009854 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 269796009855 NADP binding site [chemical binding]; other site 269796009856 dimer interface [polypeptide binding]; other site 269796009857 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 269796009858 dimer interaction site [polypeptide binding]; other site 269796009859 substrate-binding tunnel; other site 269796009860 active site 269796009861 catalytic site [active] 269796009862 substrate binding site [chemical binding]; other site 269796009863 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 269796009864 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 269796009865 active site 269796009866 Riboflavin kinase; Region: Flavokinase; smart00904 269796009867 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 269796009868 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 269796009869 active site 269796009870 HIGH motif; other site 269796009871 KMSKS motif; other site 269796009872 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 269796009873 tRNA binding surface [nucleotide binding]; other site 269796009874 anticodon binding site; other site 269796009875 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 269796009876 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 269796009877 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 269796009878 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 269796009879 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 269796009880 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 269796009881 active site 269796009882 SAM binding site [chemical binding]; other site 269796009883 homodimer interface [polypeptide binding]; other site 269796009884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796009885 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 269796009886 putative substrate translocation pore; other site 269796009887 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 269796009888 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 269796009889 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 269796009890 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 269796009891 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 269796009892 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 269796009893 Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291 269796009894 subunit L interface; other site 269796009895 subunit H interface; other site 269796009896 bacteriopheophytin binding site; other site 269796009897 carotenoid binding site; other site 269796009898 bacteriochlorophyll binding site; other site 269796009899 cytochrome C interface; other site 269796009900 quinone binding site; other site 269796009901 Fe binding site [ion binding]; other site 269796009902 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 269796009903 subunit M interface; other site 269796009904 subunit H interface; other site 269796009905 quinone binding site; other site 269796009906 bacteriopheophytin binding site; other site 269796009907 bacteriochlorophyll binding site; other site 269796009908 cytochrome C subunit interface; other site 269796009909 Fe binding site [ion binding]; other site 269796009910 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 269796009911 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 269796009912 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 269796009913 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 269796009914 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 269796009915 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 269796009916 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796009917 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 269796009918 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 269796009919 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 269796009920 putative NAD(P) binding site [chemical binding]; other site 269796009921 O-methyltransferase; Region: Methyltransf_2; pfam00891 269796009922 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 269796009923 substrate binding pocket [chemical binding]; other site 269796009924 chain length determination region; other site 269796009925 substrate-Mg2+ binding site; other site 269796009926 catalytic residues [active] 269796009927 aspartate-rich region 1; other site 269796009928 active site lid residues [active] 269796009929 aspartate-rich region 2; other site 269796009930 phytoene desaturase; Region: crtI_fam; TIGR02734 269796009931 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796009932 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 269796009933 tricarballylate dehydrogenase; Validated; Region: PRK08274 269796009934 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796009935 CitB domain protein; Region: CitB; TIGR02484 269796009936 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 269796009937 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 269796009938 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 269796009939 active site 269796009940 SAM binding site [chemical binding]; other site 269796009941 homodimer interface [polypeptide binding]; other site 269796009942 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 269796009943 active site 269796009944 SAM binding site [chemical binding]; other site 269796009945 homodimer interface [polypeptide binding]; other site 269796009946 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 269796009947 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 269796009948 active site 269796009949 putative homodimer interface [polypeptide binding]; other site 269796009950 SAM binding site [chemical binding]; other site 269796009951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796009952 S-adenosylmethionine binding site [chemical binding]; other site 269796009953 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796009954 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 269796009955 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 269796009956 phosphate acetyltransferase; Reviewed; Region: PRK05632 269796009957 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796009958 DRTGG domain; Region: DRTGG; pfam07085 269796009959 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 269796009960 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 269796009961 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 269796009962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796009963 FeS/SAM binding site; other site 269796009964 Pyruvate formate lyase 1; Region: PFL1; cd01678 269796009965 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 269796009966 coenzyme A binding site [chemical binding]; other site 269796009967 active site 269796009968 catalytic residues [active] 269796009969 glycine loop; other site 269796009970 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 269796009971 Carbon starvation protein CstA; Region: CstA; pfam02554 269796009972 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 269796009973 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 269796009974 catalytic triad [active] 269796009975 metal binding site [ion binding]; metal-binding site 269796009976 conserved cis-peptide bond; other site 269796009977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 269796009978 Transcriptional regulators [Transcription]; Region: GntR; COG1802 269796009979 DNA-binding site [nucleotide binding]; DNA binding site 269796009980 FCD domain; Region: FCD; pfam07729 269796009981 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 269796009982 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269796009983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796009984 homodimer interface [polypeptide binding]; other site 269796009985 catalytic residue [active] 269796009986 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 269796009987 iron binding site [ion binding]; other site 269796009988 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 269796009989 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 269796009990 SOUL heme-binding protein; Region: SOUL; pfam04832 269796009991 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 269796009992 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 269796009993 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 269796009994 inhibitor-cofactor binding pocket; inhibition site 269796009995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796009996 catalytic residue [active] 269796009997 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 269796009998 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 269796009999 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 269796010000 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 269796010001 catalytic triad [active] 269796010002 conserved cis-peptide bond; other site 269796010003 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 269796010004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796010005 dimer interface [polypeptide binding]; other site 269796010006 conserved gate region; other site 269796010007 putative PBP binding loops; other site 269796010008 ABC-ATPase subunit interface; other site 269796010009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796010010 dimer interface [polypeptide binding]; other site 269796010011 conserved gate region; other site 269796010012 putative PBP binding loops; other site 269796010013 ABC-ATPase subunit interface; other site 269796010014 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 269796010015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796010016 Walker A/P-loop; other site 269796010017 ATP binding site [chemical binding]; other site 269796010018 Q-loop/lid; other site 269796010019 ABC transporter signature motif; other site 269796010020 Walker B; other site 269796010021 D-loop; other site 269796010022 H-loop/switch region; other site 269796010023 TOBE domain; Region: TOBE_2; pfam08402 269796010024 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 269796010025 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 269796010026 active site 269796010027 substrate binding site [chemical binding]; other site 269796010028 Phosphotransferase enzyme family; Region: APH; pfam01636 269796010029 ATP binding site [chemical binding]; other site 269796010030 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 269796010031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269796010032 NAD(P) binding site [chemical binding]; other site 269796010033 active site 269796010034 General stress protein [General function prediction only]; Region: GsiB; COG3729 269796010035 General stress protein [General function prediction only]; Region: GsiB; COG3729 269796010036 LTXXQ motif family protein; Region: LTXXQ; pfam07813 269796010037 Nuclease-related domain; Region: NERD; pfam08378 269796010038 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 269796010039 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 269796010040 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 269796010041 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 269796010042 active site 269796010043 metal-binding site [ion binding] 269796010044 nucleotide-binding site [chemical binding]; other site 269796010045 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 269796010046 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 269796010047 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 269796010048 Ligand Binding Site [chemical binding]; other site 269796010049 Molecular Tunnel; other site 269796010050 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 269796010051 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 269796010052 glutaminase active site [active] 269796010053 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 269796010054 dimer interface [polypeptide binding]; other site 269796010055 active site 269796010056 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 269796010057 dimer interface [polypeptide binding]; other site 269796010058 active site 269796010059 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 269796010060 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 269796010061 Substrate binding site; other site 269796010062 Mg++ binding site; other site 269796010063 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 269796010064 active site 269796010065 substrate binding site [chemical binding]; other site 269796010066 CoA binding site [chemical binding]; other site 269796010067 phosphoglycolate phosphatase; Provisional; Region: PRK13222 269796010068 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 269796010069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269796010070 motif II; other site 269796010071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 269796010072 hypothetical protein; Validated; Region: PRK06217 269796010073 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 269796010074 EamA-like transporter family; Region: EamA; pfam00892 269796010075 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 269796010076 Staphylococcal nuclease homologue; Region: SNase; cl00140 269796010077 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 269796010078 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 269796010079 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 269796010080 HAMP domain; Region: HAMP; pfam00672 269796010081 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796010082 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796010083 dimer interface [polypeptide binding]; other site 269796010084 putative CheW interface [polypeptide binding]; other site 269796010085 tellurite resistance protein terB; Region: terB; cd07176 269796010086 putative metal binding site [ion binding]; other site 269796010087 GAF domain; Region: GAF_3; pfam13492 269796010088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796010089 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 269796010090 putative active site [active] 269796010091 heme pocket [chemical binding]; other site 269796010092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796010093 dimer interface [polypeptide binding]; other site 269796010094 phosphorylation site [posttranslational modification] 269796010095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796010096 ATP binding site [chemical binding]; other site 269796010097 Mg2+ binding site [ion binding]; other site 269796010098 G-X-G motif; other site 269796010099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796010100 active site 269796010101 phosphorylation site [posttranslational modification] 269796010102 intermolecular recognition site; other site 269796010103 dimerization interface [polypeptide binding]; other site 269796010104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796010105 active site 269796010106 phosphorylation site [posttranslational modification] 269796010107 intermolecular recognition site; other site 269796010108 dimerization interface [polypeptide binding]; other site 269796010109 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 269796010110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269796010111 catalytic residue [active] 269796010112 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 269796010113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 269796010114 DNA-binding site [nucleotide binding]; DNA binding site 269796010115 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269796010116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796010117 homodimer interface [polypeptide binding]; other site 269796010118 catalytic residue [active] 269796010119 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 269796010120 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 269796010121 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 269796010122 Radical SAM superfamily; Region: Radical_SAM; pfam04055 269796010123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796010124 FeS/SAM binding site; other site 269796010125 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 269796010126 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 269796010127 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269796010128 catalytic residue [active] 269796010129 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 269796010130 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269796010131 catalytic residue [active] 269796010132 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 269796010133 lipoyl attachment site [posttranslational modification]; other site 269796010134 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 269796010135 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 269796010136 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 269796010137 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 269796010138 Phosphotransferase enzyme family; Region: APH; pfam01636 269796010139 putative active site [active] 269796010140 putative substrate binding site [chemical binding]; other site 269796010141 ATP binding site [chemical binding]; other site 269796010142 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 269796010143 RNA/DNA hybrid binding site [nucleotide binding]; other site 269796010144 active site 269796010145 aromatic amino acid exporter; Provisional; Region: PRK11689 269796010146 EamA-like transporter family; Region: EamA; cl17759 269796010147 putative transporter; Provisional; Region: PRK10504 269796010148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796010149 putative substrate translocation pore; other site 269796010150 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 269796010151 catalytic triad [active] 269796010152 dimer interface [polypeptide binding]; other site 269796010153 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 269796010154 Sulfite exporter TauE/SafE; Region: TauE; cl19196 269796010155 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 269796010156 DsbD alpha interface [polypeptide binding]; other site 269796010157 catalytic residues [active] 269796010158 Putative transcriptional regulator [Transcription]; Region: COG1678 269796010159 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 269796010160 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 269796010161 B12 binding site [chemical binding]; other site 269796010162 cobalt ligand [ion binding]; other site 269796010163 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 269796010164 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 269796010165 putative NAD(P) binding site [chemical binding]; other site 269796010166 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 269796010167 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 269796010168 active site 269796010169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796010170 non-specific DNA binding site [nucleotide binding]; other site 269796010171 salt bridge; other site 269796010172 sequence-specific DNA binding site [nucleotide binding]; other site 269796010173 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 269796010174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796010175 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796010176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796010177 non-specific DNA binding site [nucleotide binding]; other site 269796010178 salt bridge; other site 269796010179 sequence-specific DNA binding site [nucleotide binding]; other site 269796010180 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 269796010181 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 269796010182 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269796010183 dimerization interface [polypeptide binding]; other site 269796010184 putative DNA binding site [nucleotide binding]; other site 269796010185 putative Zn2+ binding site [ion binding]; other site 269796010186 AsnC family; Region: AsnC_trans_reg; pfam01037 269796010187 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796010188 EamA-like transporter family; Region: EamA; pfam00892 269796010189 putative mechanosensitive channel protein; Provisional; Region: PRK11465 269796010190 Mechanosensitive ion channel; Region: MS_channel; pfam00924 269796010191 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 269796010192 active site 269796010193 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 269796010194 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 269796010195 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 269796010196 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 269796010197 Ligand binding site [chemical binding]; other site 269796010198 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 269796010199 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 269796010200 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 269796010201 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 269796010202 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 269796010203 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 269796010204 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 269796010205 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 269796010206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796010207 non-specific DNA binding site [nucleotide binding]; other site 269796010208 sequence-specific DNA binding site [nucleotide binding]; other site 269796010209 salt bridge; other site 269796010210 Predicted flavoprotein [General function prediction only]; Region: COG0431 269796010211 GTP-binding protein Der; Reviewed; Region: PRK00093 269796010212 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 269796010213 G1 box; other site 269796010214 GTP/Mg2+ binding site [chemical binding]; other site 269796010215 Switch I region; other site 269796010216 G2 box; other site 269796010217 Switch II region; other site 269796010218 G3 box; other site 269796010219 G4 box; other site 269796010220 G5 box; other site 269796010221 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 269796010222 G1 box; other site 269796010223 GTP/Mg2+ binding site [chemical binding]; other site 269796010224 Switch I region; other site 269796010225 G2 box; other site 269796010226 G3 box; other site 269796010227 Switch II region; other site 269796010228 G4 box; other site 269796010229 G5 box; other site 269796010230 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 269796010231 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 269796010232 Trp docking motif [polypeptide binding]; other site 269796010233 active site 269796010234 PQQ-like domain; Region: PQQ_2; pfam13360 269796010235 PQQ-like domain; Region: PQQ_2; pfam13360 269796010236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 269796010237 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 269796010238 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 269796010239 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 269796010240 active site 269796010241 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796010242 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 269796010243 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 269796010244 putative active site [active] 269796010245 putative catalytic site [active] 269796010246 Right handed beta helix region; Region: Beta_helix; pfam13229 269796010247 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 269796010248 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 269796010249 probable O-glycosylation ligase, exosortase A-associated; Region: PEP_O_lig_1; TIGR03097 269796010250 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 269796010251 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 269796010252 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796010253 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 269796010254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796010255 binding surface 269796010256 TPR motif; other site 269796010257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796010258 TPR motif; other site 269796010259 binding surface 269796010260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796010261 TPR motif; other site 269796010262 binding surface 269796010263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796010264 TPR motif; other site 269796010265 binding surface 269796010266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796010267 TPR motif; other site 269796010268 binding surface 269796010269 PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353 269796010270 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 269796010271 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 269796010272 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 269796010273 Bacterial sugar transferase; Region: Bac_transf; pfam02397 269796010274 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 269796010275 GAF domain; Region: GAF_3; pfam13492 269796010276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796010277 dimer interface [polypeptide binding]; other site 269796010278 phosphorylation site [posttranslational modification] 269796010279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796010280 ATP binding site [chemical binding]; other site 269796010281 Mg2+ binding site [ion binding]; other site 269796010282 G-X-G motif; other site 269796010283 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 269796010284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796010285 active site 269796010286 phosphorylation site [posttranslational modification] 269796010287 intermolecular recognition site; other site 269796010288 dimerization interface [polypeptide binding]; other site 269796010289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796010290 Walker A motif; other site 269796010291 ATP binding site [chemical binding]; other site 269796010292 Walker B motif; other site 269796010293 arginine finger; other site 269796010294 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 269796010295 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 269796010296 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269796010297 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 269796010298 Predicted integral membrane protein [Function unknown]; Region: COG5652 269796010299 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796010300 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 269796010301 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 269796010302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269796010303 NAD(P) binding site [chemical binding]; other site 269796010304 active site 269796010305 acyl-CoA synthetase; Validated; Region: PRK05850 269796010306 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 269796010307 acyl-activating enzyme (AAE) consensus motif; other site 269796010308 active site 269796010309 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 269796010310 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 269796010311 Condensation domain; Region: Condensation; cl19241 269796010312 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 269796010313 acyl-activating enzyme (AAE) consensus motif; other site 269796010314 AMP binding site [chemical binding]; other site 269796010315 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 269796010316 Putative lysophospholipase; Region: Hydrolase_4; cl19140 269796010317 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 269796010318 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269796010319 ligand binding site [chemical binding]; other site 269796010320 flexible hinge region; other site 269796010321 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 269796010322 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 269796010323 active site 269796010324 nucleophile elbow; other site 269796010325 putative protein phosphatase; Region: PHA02239 269796010326 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 269796010327 active site 269796010328 metal binding site [ion binding]; metal-binding site 269796010329 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 269796010330 FAD binding domain; Region: FAD_binding_4; pfam01565 269796010331 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 269796010332 FemAB-related protein, PEP-CTERM system-associated; Region: pepcterm_femAB; TIGR03019 269796010333 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 269796010334 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 269796010335 putative active site [active] 269796010336 putative catalytic site [active] 269796010337 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 269796010338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796010339 Walker A motif; other site 269796010340 ATP binding site [chemical binding]; other site 269796010341 Walker B motif; other site 269796010342 arginine finger; other site 269796010343 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 269796010344 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 269796010345 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 269796010346 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 269796010347 Chain length determinant protein; Region: Wzz; pfam02706 269796010348 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 269796010349 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796010350 exosortase A; Region: exosortase_1; TIGR03109 269796010351 exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152 269796010352 EpsI family protein; Region: EpsI_fam; TIGR02914 269796010353 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 269796010354 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 269796010355 active site 269796010356 dimer interface [polypeptide binding]; other site 269796010357 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 269796010358 Ligand Binding Site [chemical binding]; other site 269796010359 Molecular Tunnel; other site 269796010360 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 269796010361 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 269796010362 Putative lysophospholipase; Region: Hydrolase_4; cl19140 269796010363 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 269796010364 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 269796010365 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 269796010366 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 269796010367 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 269796010368 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 269796010369 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 269796010370 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 269796010371 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 269796010372 Helix-turn-helix domain; Region: HTH_18; pfam12833 269796010373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269796010374 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 269796010375 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 269796010376 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 269796010377 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 269796010378 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 269796010379 Walker A/P-loop; other site 269796010380 ATP binding site [chemical binding]; other site 269796010381 Q-loop/lid; other site 269796010382 ABC transporter signature motif; other site 269796010383 Walker B; other site 269796010384 D-loop; other site 269796010385 H-loop/switch region; other site 269796010386 HlyD family secretion protein; Region: HlyD; pfam00529 269796010387 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 269796010388 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269796010389 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796010390 PAS fold; Region: PAS_3; pfam08447 269796010391 putative active site [active] 269796010392 heme pocket [chemical binding]; other site 269796010393 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796010394 metal binding site [ion binding]; metal-binding site 269796010395 active site 269796010396 I-site; other site 269796010397 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 269796010398 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 269796010399 acyl-activating enzyme (AAE) consensus motif; other site 269796010400 putative AMP binding site [chemical binding]; other site 269796010401 putative active site [active] 269796010402 putative CoA binding site [chemical binding]; other site 269796010403 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 269796010404 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 269796010405 dimer interface [polypeptide binding]; other site 269796010406 active site 269796010407 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 269796010408 catalytic residues [active] 269796010409 substrate binding site [chemical binding]; other site 269796010410 ParA-like protein; Provisional; Region: PHA02518 269796010411 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 269796010412 P-loop; other site 269796010413 Magnesium ion binding site [ion binding]; other site 269796010414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796010415 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 269796010416 putative active site [active] 269796010417 heme pocket [chemical binding]; other site 269796010418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796010419 putative active site [active] 269796010420 heme pocket [chemical binding]; other site 269796010421 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796010422 PAS domain; Region: PAS_9; pfam13426 269796010423 putative active site [active] 269796010424 heme pocket [chemical binding]; other site 269796010425 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796010426 metal binding site [ion binding]; metal-binding site 269796010427 active site 269796010428 I-site; other site 269796010429 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796010430 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 269796010431 putative ligand binding site [chemical binding]; other site 269796010432 Transcriptional regulators [Transcription]; Region: FadR; COG2186 269796010433 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 269796010434 DNA-binding site [nucleotide binding]; DNA binding site 269796010435 FCD domain; Region: FCD; pfam07729 269796010436 GntP family permease; Region: GntP_permease; pfam02447 269796010437 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 269796010438 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 269796010439 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 269796010440 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 269796010441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 269796010442 putative aldolase; Validated; Region: PRK08130 269796010443 intersubunit interface [polypeptide binding]; other site 269796010444 active site 269796010445 Zn2+ binding site [ion binding]; other site 269796010446 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 269796010447 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 269796010448 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 269796010449 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 269796010450 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 269796010451 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 269796010452 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 269796010453 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 269796010454 FtsX-like permease family; Region: FtsX; pfam02687 269796010455 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 269796010456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796010457 Walker A/P-loop; other site 269796010458 ATP binding site [chemical binding]; other site 269796010459 Q-loop/lid; other site 269796010460 ABC transporter signature motif; other site 269796010461 Walker B; other site 269796010462 D-loop; other site 269796010463 H-loop/switch region; other site 269796010464 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 269796010465 metal ion-dependent adhesion site (MIDAS); other site 269796010466 Inositol 1,4,5-trisphosphate/ryanodine receptor; Region: Ins145_P3_rec; cl19745 269796010467 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 269796010468 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 269796010469 Virulence factor SrfB; Region: SrfB; pfam07520 269796010470 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 269796010471 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 269796010472 metal ion-dependent adhesion site (MIDAS); other site 269796010473 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 269796010474 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 269796010475 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 269796010476 metabolite-proton symporter; Region: 2A0106; TIGR00883 269796010477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796010478 putative substrate translocation pore; other site 269796010479 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796010480 EamA-like transporter family; Region: EamA; pfam00892 269796010481 EamA-like transporter family; Region: EamA; pfam00892 269796010482 prephenate dehydratase; Provisional; Region: PRK11899 269796010483 Prephenate dehydratase; Region: PDT; pfam00800 269796010484 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 269796010485 putative L-Phe binding site [chemical binding]; other site 269796010486 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 269796010487 Ligand binding site; other site 269796010488 oligomer interface; other site 269796010489 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 269796010490 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 269796010491 active site 269796010492 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 269796010493 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 269796010494 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 269796010495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796010496 dimer interface [polypeptide binding]; other site 269796010497 conserved gate region; other site 269796010498 putative PBP binding loops; other site 269796010499 ABC-ATPase subunit interface; other site 269796010500 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 269796010501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796010502 dimer interface [polypeptide binding]; other site 269796010503 conserved gate region; other site 269796010504 putative PBP binding loops; other site 269796010505 ABC-ATPase subunit interface; other site 269796010506 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 269796010507 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796010508 Walker A/P-loop; other site 269796010509 ATP binding site [chemical binding]; other site 269796010510 Q-loop/lid; other site 269796010511 ABC transporter signature motif; other site 269796010512 Walker B; other site 269796010513 D-loop; other site 269796010514 H-loop/switch region; other site 269796010515 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 269796010516 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269796010517 Walker A/P-loop; other site 269796010518 ATP binding site [chemical binding]; other site 269796010519 Q-loop/lid; other site 269796010520 ABC transporter signature motif; other site 269796010521 Walker B; other site 269796010522 D-loop; other site 269796010523 H-loop/switch region; other site 269796010524 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 269796010525 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 269796010526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796010527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796010528 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796010529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796010530 putative substrate translocation pore; other site 269796010531 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 269796010532 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 269796010533 GatB domain; Region: GatB_Yqey; smart00845 269796010534 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 269796010535 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 269796010536 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 269796010537 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 269796010538 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 269796010539 GAF domain; Region: GAF; cl17456 269796010540 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269796010541 Zn2+ binding site [ion binding]; other site 269796010542 Mg2+ binding site [ion binding]; other site 269796010543 Predicted membrane protein [Function unknown]; Region: COG5373 269796010544 Predicted permeases [General function prediction only]; Region: COG0679 269796010545 Dihaem cytochrome c; Region: DHC; pfam09626 269796010546 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 269796010547 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 269796010548 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796010549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796010550 active site 269796010551 phosphorylation site [posttranslational modification] 269796010552 intermolecular recognition site; other site 269796010553 dimerization interface [polypeptide binding]; other site 269796010554 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269796010555 DNA binding site [nucleotide binding] 269796010556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796010557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796010558 dimerization interface [polypeptide binding]; other site 269796010559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796010560 ATP binding site [chemical binding]; other site 269796010561 Mg2+ binding site [ion binding]; other site 269796010562 G-X-G motif; other site 269796010563 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 269796010564 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 269796010565 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 269796010566 dihydroorotase; Validated; Region: PRK09059 269796010567 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 269796010568 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 269796010569 active site 269796010570 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 269796010571 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 269796010572 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 269796010573 putative C-terminal domain interface [polypeptide binding]; other site 269796010574 putative GSH binding site (G-site) [chemical binding]; other site 269796010575 putative dimer interface [polypeptide binding]; other site 269796010576 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 269796010577 putative N-terminal domain interface [polypeptide binding]; other site 269796010578 putative substrate binding pocket (H-site) [chemical binding]; other site 269796010579 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 269796010580 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 269796010581 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 269796010582 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 269796010583 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 269796010584 HicB family; Region: HicB; pfam05534 269796010585 YcfA-like protein; Region: YcfA; pfam07927 269796010586 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 269796010587 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 269796010588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796010589 dimer interface [polypeptide binding]; other site 269796010590 conserved gate region; other site 269796010591 putative PBP binding loops; other site 269796010592 ABC-ATPase subunit interface; other site 269796010593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796010594 dimer interface [polypeptide binding]; other site 269796010595 conserved gate region; other site 269796010596 putative PBP binding loops; other site 269796010597 ABC-ATPase subunit interface; other site 269796010598 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 269796010599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796010600 Walker A/P-loop; other site 269796010601 ATP binding site [chemical binding]; other site 269796010602 Q-loop/lid; other site 269796010603 ABC transporter signature motif; other site 269796010604 Walker B; other site 269796010605 D-loop; other site 269796010606 H-loop/switch region; other site 269796010607 TOBE domain; Region: TOBE_2; pfam08402 269796010608 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 269796010609 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 269796010610 active site 269796010611 interdomain interaction site; other site 269796010612 putative metal-binding site [ion binding]; other site 269796010613 nucleotide binding site [chemical binding]; other site 269796010614 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 269796010615 domain I; other site 269796010616 DNA binding groove [nucleotide binding] 269796010617 phosphate binding site [ion binding]; other site 269796010618 domain II; other site 269796010619 domain III; other site 269796010620 nucleotide binding site [chemical binding]; other site 269796010621 catalytic site [active] 269796010622 domain IV; other site 269796010623 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 269796010624 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 269796010625 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 269796010626 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 269796010627 ribonuclease R; Region: RNase_R; TIGR02063 269796010628 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 269796010629 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 269796010630 RNA binding site [nucleotide binding]; other site 269796010631 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 269796010632 protein binding site [polypeptide binding]; other site 269796010633 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 269796010634 Catalytic dyad [active] 269796010635 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 269796010636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796010637 active site 269796010638 phosphorylation site [posttranslational modification] 269796010639 intermolecular recognition site; other site 269796010640 dimerization interface [polypeptide binding]; other site 269796010641 Protein of unknown function (DUF423); Region: DUF423; pfam04241 269796010642 Domain of unknown function DUF29; Region: DUF29; pfam01724 269796010643 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 269796010644 RNA/DNA hybrid binding site [nucleotide binding]; other site 269796010645 active site 269796010646 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 269796010647 Hemerythrin; Region: Hemerythrin; cd12107 269796010648 Fe binding site [ion binding]; other site 269796010649 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 269796010650 PAS fold; Region: PAS_7; pfam12860 269796010651 PAS domain S-box; Region: sensory_box; TIGR00229 269796010652 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796010653 putative active site [active] 269796010654 heme pocket [chemical binding]; other site 269796010655 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796010656 PAS fold; Region: PAS_3; pfam08447 269796010657 putative active site [active] 269796010658 heme pocket [chemical binding]; other site 269796010659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796010660 dimer interface [polypeptide binding]; other site 269796010661 phosphorylation site [posttranslational modification] 269796010662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796010663 ATP binding site [chemical binding]; other site 269796010664 Mg2+ binding site [ion binding]; other site 269796010665 G-X-G motif; other site 269796010666 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 269796010667 homodimer interface [polypeptide binding]; other site 269796010668 substrate-cofactor binding pocket; other site 269796010669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796010670 catalytic residue [active] 269796010671 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 269796010672 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 269796010673 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 269796010674 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 269796010675 putative metal binding site [ion binding]; other site 269796010676 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 269796010677 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269796010678 N-terminal plug; other site 269796010679 ligand-binding site [chemical binding]; other site 269796010680 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 269796010681 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 269796010682 ABC-ATPase subunit interface; other site 269796010683 dimer interface [polypeptide binding]; other site 269796010684 putative PBP binding regions; other site 269796010685 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 269796010686 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 269796010687 Walker A/P-loop; other site 269796010688 ATP binding site [chemical binding]; other site 269796010689 Q-loop/lid; other site 269796010690 ABC transporter signature motif; other site 269796010691 Walker B; other site 269796010692 D-loop; other site 269796010693 H-loop/switch region; other site 269796010694 RES domain; Region: RES; smart00953 269796010695 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 269796010696 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 269796010697 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 269796010698 NAD binding site [chemical binding]; other site 269796010699 homotetramer interface [polypeptide binding]; other site 269796010700 homodimer interface [polypeptide binding]; other site 269796010701 substrate binding site [chemical binding]; other site 269796010702 active site 269796010703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796010704 S-adenosylmethionine binding site [chemical binding]; other site 269796010705 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 269796010706 putative coenzyme Q binding site [chemical binding]; other site 269796010707 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 269796010708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796010709 active site 269796010710 phosphorylation site [posttranslational modification] 269796010711 intermolecular recognition site; other site 269796010712 dimerization interface [polypeptide binding]; other site 269796010713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 269796010714 DNA binding residues [nucleotide binding] 269796010715 dimerization interface [polypeptide binding]; other site 269796010716 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796010717 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 269796010718 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 269796010719 metal binding site [ion binding]; metal-binding site 269796010720 nucleotidyl binding site; other site 269796010721 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 269796010722 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 269796010723 conserved cys residue [active] 269796010724 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 269796010725 active site 269796010726 Zn binding site [ion binding]; other site 269796010727 threonine synthase; Validated; Region: PRK09225 269796010728 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 269796010729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796010730 catalytic residue [active] 269796010731 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 269796010732 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 269796010733 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 269796010734 macrolide transporter subunit MacA; Provisional; Region: PRK11578 269796010735 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269796010736 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796010737 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 269796010738 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 269796010739 Walker A/P-loop; other site 269796010740 ATP binding site [chemical binding]; other site 269796010741 Q-loop/lid; other site 269796010742 ABC transporter signature motif; other site 269796010743 Walker B; other site 269796010744 D-loop; other site 269796010745 H-loop/switch region; other site 269796010746 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 269796010747 FtsX-like permease family; Region: FtsX; pfam02687 269796010748 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 269796010749 Outer membrane efflux protein; Region: OEP; pfam02321 269796010750 Outer membrane efflux protein; Region: OEP; pfam02321 269796010751 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 269796010752 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 269796010753 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 269796010754 Protoglobin; Region: Protoglobin; pfam11563 269796010755 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796010756 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796010757 dimer interface [polypeptide binding]; other site 269796010758 putative CheW interface [polypeptide binding]; other site 269796010759 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269796010760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796010761 non-specific DNA binding site [nucleotide binding]; other site 269796010762 salt bridge; other site 269796010763 sequence-specific DNA binding site [nucleotide binding]; other site 269796010764 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 269796010765 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 269796010766 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 269796010767 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 269796010768 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 269796010769 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 269796010770 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 269796010771 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 269796010772 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 269796010773 Walker A/P-loop; other site 269796010774 ATP binding site [chemical binding]; other site 269796010775 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 269796010776 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 269796010777 ABC transporter signature motif; other site 269796010778 Walker B; other site 269796010779 D-loop; other site 269796010780 H-loop/switch region; other site 269796010781 Thioredoxin; Region: Thioredoxin_4; pfam13462 269796010782 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 269796010783 Protein of unknown function (DUF721); Region: DUF721; cl02324 269796010784 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 269796010785 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 269796010786 minor groove reading motif; other site 269796010787 helix-hairpin-helix signature motif; other site 269796010788 substrate binding pocket [chemical binding]; other site 269796010789 active site 269796010790 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 269796010791 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 269796010792 DNA binding and oxoG recognition site [nucleotide binding] 269796010793 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 269796010794 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 269796010795 NAD binding site [chemical binding]; other site 269796010796 putative substrate binding site 2 [chemical binding]; other site 269796010797 putative substrate binding site 1 [chemical binding]; other site 269796010798 active site 269796010799 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 269796010800 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 269796010801 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 269796010802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796010803 Walker A/P-loop; other site 269796010804 ATP binding site [chemical binding]; other site 269796010805 Q-loop/lid; other site 269796010806 ABC transporter signature motif; other site 269796010807 Walker B; other site 269796010808 D-loop; other site 269796010809 H-loop/switch region; other site 269796010810 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 269796010811 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 269796010812 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 269796010813 putative active site [active] 269796010814 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 269796010815 putative acyl-acceptor binding pocket; other site 269796010816 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 269796010817 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 269796010818 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 269796010819 active site 269796010820 dimer interface [polypeptide binding]; other site 269796010821 effector binding site; other site 269796010822 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 269796010823 putative active site pocket [active] 269796010824 dimerization interface [polypeptide binding]; other site 269796010825 putative catalytic residue [active] 269796010826 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 269796010827 CHAT domain; Region: CHAT; pfam12770 269796010828 AAA ATPase domain; Region: AAA_16; pfam13191 269796010829 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 269796010830 prephenate dehydrogenase; Validated; Region: PRK08507 269796010831 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 269796010832 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269796010833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796010834 homodimer interface [polypeptide binding]; other site 269796010835 catalytic residue [active] 269796010836 hypothetical protein; Provisional; Region: PRK06034 269796010837 Chorismate mutase type II; Region: CM_2; cl00693 269796010838 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 269796010839 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 269796010840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796010841 S-adenosylmethionine binding site [chemical binding]; other site 269796010842 Methyltransferase domain; Region: Methyltransf_23; pfam13489 269796010843 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 269796010844 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 269796010845 putative glutathione S-transferase; Provisional; Region: PRK10357 269796010846 putative C-terminal domain interface [polypeptide binding]; other site 269796010847 putative GSH binding site (G-site) [chemical binding]; other site 269796010848 putative dimer interface [polypeptide binding]; other site 269796010849 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 269796010850 dimer interface [polypeptide binding]; other site 269796010851 N-terminal domain interface [polypeptide binding]; other site 269796010852 putative substrate binding pocket (H-site) [chemical binding]; other site 269796010853 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796010854 EamA-like transporter family; Region: EamA; pfam00892 269796010855 EamA-like transporter family; Region: EamA; pfam00892 269796010856 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 269796010857 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 269796010858 CGNR zinc finger; Region: zf-CGNR; pfam11706 269796010859 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 269796010860 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 269796010861 dimerization interface [polypeptide binding]; other site 269796010862 domain crossover interface; other site 269796010863 redox-dependent activation switch; other site 269796010864 ornithine carbamoyltransferase; Provisional; Region: PRK00779 269796010865 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 269796010866 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 269796010867 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 269796010868 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 269796010869 inhibitor-cofactor binding pocket; inhibition site 269796010870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796010871 catalytic residue [active] 269796010872 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 269796010873 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 269796010874 NADP binding site [chemical binding]; other site 269796010875 homopentamer interface [polypeptide binding]; other site 269796010876 substrate binding site [chemical binding]; other site 269796010877 active site 269796010878 Membrane fusogenic activity; Region: BMFP; pfam04380 269796010879 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 269796010880 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 269796010881 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 269796010882 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 269796010883 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 269796010884 phasin family protein; Region: phasin; TIGR01841 269796010885 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 269796010886 dimer interface [polypeptide binding]; other site 269796010887 putative tRNA-binding site [nucleotide binding]; other site 269796010888 two-component response regulator; Provisional; Region: PRK09191 269796010889 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 269796010890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796010891 active site 269796010892 phosphorylation site [posttranslational modification] 269796010893 intermolecular recognition site; other site 269796010894 dimerization interface [polypeptide binding]; other site 269796010895 RNA polymerase sigma factor; Provisional; Region: PRK12547 269796010896 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269796010897 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 269796010898 DNA binding residues [nucleotide binding] 269796010899 HAMP domain; Region: HAMP; pfam00672 269796010900 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 269796010901 Histidine kinase; Region: HisKA_2; pfam07568 269796010902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796010903 ATP binding site [chemical binding]; other site 269796010904 Mg2+ binding site [ion binding]; other site 269796010905 G-X-G motif; other site 269796010906 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 269796010907 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 269796010908 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 269796010909 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 269796010910 putative active site [active] 269796010911 putative metal binding site [ion binding]; other site 269796010912 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 269796010913 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 269796010914 flagellin; Provisional; Region: PRK14708 269796010915 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 269796010916 tetramer interface [polypeptide binding]; other site 269796010917 dimer interface [polypeptide binding]; other site 269796010918 circadian clock protein KaiC; Reviewed; Region: PRK09302 269796010919 KaiC; Region: KaiC; pfam06745 269796010920 Walker A motif; other site 269796010921 ATP binding site [chemical binding]; other site 269796010922 Walker B motif; other site 269796010923 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 269796010924 Walker A motif; other site 269796010925 Walker A motif; other site 269796010926 ATP binding site [chemical binding]; other site 269796010927 Walker B motif; other site 269796010928 PAS domain S-box; Region: sensory_box; TIGR00229 269796010929 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796010930 putative active site [active] 269796010931 heme pocket [chemical binding]; other site 269796010932 PAS domain S-box; Region: sensory_box; TIGR00229 269796010933 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796010934 putative active site [active] 269796010935 heme pocket [chemical binding]; other site 269796010936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 269796010937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796010938 dimer interface [polypeptide binding]; other site 269796010939 phosphorylation site [posttranslational modification] 269796010940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796010941 ATP binding site [chemical binding]; other site 269796010942 Mg2+ binding site [ion binding]; other site 269796010943 G-X-G motif; other site 269796010944 AzlC protein; Region: AzlC; pfam03591 269796010945 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 269796010946 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 269796010947 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 269796010948 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 269796010949 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 269796010950 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 269796010951 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 269796010952 Putative glucoamylase; Region: Glycoamylase; cl19893 269796010953 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 269796010954 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 269796010955 putative ligand binding site [chemical binding]; other site 269796010956 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 269796010957 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 269796010958 Walker A/P-loop; other site 269796010959 ATP binding site [chemical binding]; other site 269796010960 Q-loop/lid; other site 269796010961 ABC transporter signature motif; other site 269796010962 Walker B; other site 269796010963 D-loop; other site 269796010964 H-loop/switch region; other site 269796010965 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 269796010966 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 269796010967 Walker A/P-loop; other site 269796010968 ATP binding site [chemical binding]; other site 269796010969 Q-loop/lid; other site 269796010970 ABC transporter signature motif; other site 269796010971 Walker B; other site 269796010972 D-loop; other site 269796010973 H-loop/switch region; other site 269796010974 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 269796010975 TM-ABC transporter signature motif; other site 269796010976 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 269796010977 TM-ABC transporter signature motif; other site 269796010978 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 269796010979 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 269796010980 Transposase [DNA replication, recombination, and repair]; Region: COG5433 269796010981 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269796010982 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796010983 non-specific DNA binding site [nucleotide binding]; other site 269796010984 salt bridge; other site 269796010985 sequence-specific DNA binding site [nucleotide binding]; other site 269796010986 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 269796010987 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 269796010988 catalytic residues [active] 269796010989 catalytic nucleophile [active] 269796010990 major capsid protein; Region: PHA00201 269796010991 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 269796010992 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 269796010993 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 269796010994 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 269796010995 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 269796010996 Int/Topo IB signature motif; other site 269796010997 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223 269796010998 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269796010999 active site 269796011000 Pantoate-beta-alanine ligase; Region: PanC; cd00560 269796011001 active site 269796011002 ATP-binding site [chemical binding]; other site 269796011003 pantoate-binding site; other site 269796011004 HXXH motif; other site 269796011005 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 269796011006 oligomerization interface [polypeptide binding]; other site 269796011007 active site 269796011008 metal binding site [ion binding]; metal-binding site 269796011009 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269796011010 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 269796011011 ligand binding site [chemical binding]; other site 269796011012 flexible hinge region; other site 269796011013 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 269796011014 putative switch regulator; other site 269796011015 non-specific DNA interactions [nucleotide binding]; other site 269796011016 DNA binding site [nucleotide binding] 269796011017 sequence specific DNA binding site [nucleotide binding]; other site 269796011018 putative cAMP binding site [chemical binding]; other site 269796011019 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 269796011020 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 269796011021 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 269796011022 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 269796011023 metal-binding site [ion binding] 269796011024 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 269796011025 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 269796011026 FixH; Region: FixH; pfam05751 269796011027 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 269796011028 4Fe-4S binding domain; Region: Fer4_5; pfam12801 269796011029 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 269796011030 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 269796011031 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 269796011032 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 269796011033 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269796011034 ligand binding site [chemical binding]; other site 269796011035 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 269796011036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796011037 FeS/SAM binding site; other site 269796011038 N-terminal domain of cytochrome oxidase-cbb3, FixP; Region: FixP_N; pfam14715 269796011039 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 269796011040 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 269796011041 Cytochrome c; Region: Cytochrom_C; pfam00034 269796011042 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 269796011043 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 269796011044 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 269796011045 Low-spin heme binding site [chemical binding]; other site 269796011046 Putative water exit pathway; other site 269796011047 Binuclear center (active site) [active] 269796011048 Putative proton exit pathway; other site 269796011049 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 269796011050 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 269796011051 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 269796011052 putative RNA binding site [nucleotide binding]; other site 269796011053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 269796011054 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 269796011055 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 269796011056 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 269796011057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796011058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796011059 ATP binding site [chemical binding]; other site 269796011060 Mg2+ binding site [ion binding]; other site 269796011061 G-X-G motif; other site 269796011062 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 269796011063 Ribonuclease P; Region: Ribonuclease_P; pfam00825 269796011064 Haemolytic domain; Region: Haemolytic; pfam01809 269796011065 membrane protein insertase; Provisional; Region: PRK01318 269796011066 YidC periplasmic domain; Region: YidC_periplas; pfam14849 269796011067 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 269796011068 Predicted GTPase [General function prediction only]; Region: COG0218 269796011069 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 269796011070 G1 box; other site 269796011071 GTP/Mg2+ binding site [chemical binding]; other site 269796011072 Switch I region; other site 269796011073 G2 box; other site 269796011074 G3 box; other site 269796011075 Switch II region; other site 269796011076 G4 box; other site 269796011077 G5 box; other site 269796011078 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 269796011079 feedback inhibition sensing region; other site 269796011080 homohexameric interface [polypeptide binding]; other site 269796011081 nucleotide binding site [chemical binding]; other site 269796011082 N-acetyl-L-glutamate binding site [chemical binding]; other site 269796011083 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 269796011084 dimer interface [polypeptide binding]; other site 269796011085 active site 269796011086 catalytic residue [active] 269796011087 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 269796011088 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 269796011089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269796011090 motif II; other site 269796011091 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269796011092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796011093 non-specific DNA binding site [nucleotide binding]; other site 269796011094 salt bridge; other site 269796011095 sequence-specific DNA binding site [nucleotide binding]; other site 269796011096 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 269796011097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796011098 heme pocket [chemical binding]; other site 269796011099 putative active site [active] 269796011100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796011101 putative active site [active] 269796011102 heme pocket [chemical binding]; other site 269796011103 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796011104 metal binding site [ion binding]; metal-binding site 269796011105 active site 269796011106 I-site; other site 269796011107 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796011108 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 269796011109 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 269796011110 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796011111 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 269796011112 RmuC family; Region: RmuC; pfam02646 269796011113 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 269796011114 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 269796011115 active site 269796011116 catalytic residues [active] 269796011117 metal binding site [ion binding]; metal-binding site 269796011118 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 269796011119 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 269796011120 putative active site [active] 269796011121 substrate binding site [chemical binding]; other site 269796011122 putative cosubstrate binding site; other site 269796011123 catalytic site [active] 269796011124 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 269796011125 substrate binding site [chemical binding]; other site 269796011126 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 269796011127 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 269796011128 dimerization interface 3.5A [polypeptide binding]; other site 269796011129 active site 269796011130 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 269796011131 Protein of unknown function DUF45; Region: DUF45; pfam01863 269796011132 hypothetical protein; Provisional; Region: PRK05170 269796011133 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 269796011134 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 269796011135 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 269796011136 AlkA N-terminal domain; Region: AlkA_N; pfam06029 269796011137 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 269796011138 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 269796011139 minor groove reading motif; other site 269796011140 helix-hairpin-helix signature motif; other site 269796011141 substrate binding pocket [chemical binding]; other site 269796011142 active site 269796011143 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 269796011144 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 269796011145 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 269796011146 DNA binding site [nucleotide binding] 269796011147 active site 269796011148 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 269796011149 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796011150 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 269796011151 conserved cys residue [active] 269796011152 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 269796011153 Cu(I) binding site [ion binding]; other site 269796011154 Cytochrome C biogenesis protein transmembrane region; Region: DsbD_2; pfam13386 269796011155 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 269796011156 active site 269796011157 SAM binding site [chemical binding]; other site 269796011158 homodimer interface [polypeptide binding]; other site 269796011159 PAS domain; Region: PAS_9; pfam13426 269796011160 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796011161 putative active site [active] 269796011162 heme pocket [chemical binding]; other site 269796011163 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 269796011164 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796011165 putative active site [active] 269796011166 heme pocket [chemical binding]; other site 269796011167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796011168 dimer interface [polypeptide binding]; other site 269796011169 phosphorylation site [posttranslational modification] 269796011170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796011171 ATP binding site [chemical binding]; other site 269796011172 Mg2+ binding site [ion binding]; other site 269796011173 G-X-G motif; other site 269796011174 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 269796011175 GTP-binding protein LepA; Provisional; Region: PRK05433 269796011176 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 269796011177 G1 box; other site 269796011178 putative GEF interaction site [polypeptide binding]; other site 269796011179 GTP/Mg2+ binding site [chemical binding]; other site 269796011180 Switch I region; other site 269796011181 G2 box; other site 269796011182 G3 box; other site 269796011183 Switch II region; other site 269796011184 G4 box; other site 269796011185 G5 box; other site 269796011186 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 269796011187 Elongation Factor G, domain II; Region: EFG_II; pfam14492 269796011188 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 269796011189 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 269796011190 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 269796011191 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 269796011192 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 269796011193 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 269796011194 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 269796011195 homodimer interface [polypeptide binding]; other site 269796011196 Walker A motif; other site 269796011197 ATP binding site [chemical binding]; other site 269796011198 hydroxycobalamin binding site [chemical binding]; other site 269796011199 Walker B motif; other site 269796011200 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 269796011201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796011202 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 269796011203 dimerization interface [polypeptide binding]; other site 269796011204 substrate binding pocket [chemical binding]; other site 269796011205 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 269796011206 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796011207 EamA-like transporter family; Region: EamA; pfam00892 269796011208 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 269796011209 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 269796011210 NAD(P) binding site [chemical binding]; other site 269796011211 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 269796011212 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 269796011213 PAS domain; Region: PAS_9; pfam13426 269796011214 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796011215 putative active site [active] 269796011216 heme pocket [chemical binding]; other site 269796011217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796011218 PAS domain; Region: PAS_9; pfam13426 269796011219 putative active site [active] 269796011220 heme pocket [chemical binding]; other site 269796011221 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796011222 metal binding site [ion binding]; metal-binding site 269796011223 active site 269796011224 I-site; other site 269796011225 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 269796011226 putative active site [active] 269796011227 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796011228 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 269796011229 putative ADP-binding pocket [chemical binding]; other site 269796011230 Putative lysophospholipase; Region: Hydrolase_4; cl19140 269796011231 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 269796011232 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 269796011233 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 269796011234 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 269796011235 putative NAD(P) binding site [chemical binding]; other site 269796011236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796011237 binding surface 269796011238 TPR motif; other site 269796011239 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 269796011240 putative amphipathic alpha helix; other site 269796011241 cobyric acid synthase; Provisional; Region: PRK00784 269796011242 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796011243 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 269796011244 catalytic triad [active] 269796011245 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 269796011246 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495 269796011247 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 269796011248 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 269796011249 active site 269796011250 SAM binding site [chemical binding]; other site 269796011251 homodimer interface [polypeptide binding]; other site 269796011252 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269796011253 ligand binding site [chemical binding]; other site 269796011254 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 269796011255 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 269796011256 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 269796011257 dimer interface [polypeptide binding]; other site 269796011258 active site 269796011259 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 269796011260 putative active site [active] 269796011261 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 269796011262 Uncharacterized conserved protein [Function unknown]; Region: COG2308 269796011263 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796011264 metal binding site [ion binding]; metal-binding site 269796011265 active site 269796011266 I-site; other site 269796011267 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 269796011268 Transglycosylase; Region: Transgly; pfam00912 269796011269 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 269796011270 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 269796011271 Autoinducer binding domain; Region: Autoind_bind; pfam03472 269796011272 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 269796011273 DNA binding residues [nucleotide binding] 269796011274 dimerization interface [polypeptide binding]; other site 269796011275 Autoinducer synthetase; Region: Autoind_synth; cl17404 269796011276 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269796011277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796011278 sequence-specific DNA binding site [nucleotide binding]; other site 269796011279 salt bridge; other site 269796011280 Predicted transcriptional regulator [Transcription]; Region: COG1959 269796011281 Rrf2 family protein; Region: rrf2_super; TIGR00738 269796011282 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 269796011283 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 269796011284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796011285 dimer interface [polypeptide binding]; other site 269796011286 conserved gate region; other site 269796011287 putative PBP binding loops; other site 269796011288 ABC-ATPase subunit interface; other site 269796011289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796011290 dimer interface [polypeptide binding]; other site 269796011291 conserved gate region; other site 269796011292 putative PBP binding loops; other site 269796011293 ABC-ATPase subunit interface; other site 269796011294 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 269796011295 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 269796011296 Walker A/P-loop; other site 269796011297 ATP binding site [chemical binding]; other site 269796011298 Q-loop/lid; other site 269796011299 ABC transporter signature motif; other site 269796011300 Walker B; other site 269796011301 D-loop; other site 269796011302 H-loop/switch region; other site 269796011303 TOBE-like domain; Region: TOBE_3; pfam12857 269796011304 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 269796011305 transmembrane helices; other site 269796011306 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 269796011307 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 269796011308 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 269796011309 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 269796011310 substrate binding site [chemical binding]; other site 269796011311 catalytic Zn binding site [ion binding]; other site 269796011312 NAD binding site [chemical binding]; other site 269796011313 structural Zn binding site [ion binding]; other site 269796011314 dimer interface [polypeptide binding]; other site 269796011315 Predicted esterase [General function prediction only]; Region: COG0627 269796011316 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 269796011317 6-phosphofructokinase; Provisional; Region: PRK14072 269796011318 allosteric effector site; other site 269796011319 dimerization interface [polypeptide binding]; other site 269796011320 active site 269796011321 ADP/pyrophosphate binding site [chemical binding]; other site 269796011322 fructose-1,6-bisphosphate binding site; other site 269796011323 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 269796011324 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 269796011325 active site 269796011326 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 269796011327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796011328 non-specific DNA binding site [nucleotide binding]; other site 269796011329 salt bridge; other site 269796011330 sequence-specific DNA binding site [nucleotide binding]; other site 269796011331 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 269796011332 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 269796011333 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 269796011334 active site 269796011335 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 269796011336 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 269796011337 Walker A/P-loop; other site 269796011338 ATP binding site [chemical binding]; other site 269796011339 Q-loop/lid; other site 269796011340 ABC transporter signature motif; other site 269796011341 Walker B; other site 269796011342 D-loop; other site 269796011343 H-loop/switch region; other site 269796011344 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 269796011345 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 269796011346 Walker A/P-loop; other site 269796011347 ATP binding site [chemical binding]; other site 269796011348 Q-loop/lid; other site 269796011349 ABC transporter signature motif; other site 269796011350 Walker B; other site 269796011351 D-loop; other site 269796011352 H-loop/switch region; other site 269796011353 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 269796011354 TM-ABC transporter signature motif; other site 269796011355 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 269796011356 TM-ABC transporter signature motif; other site 269796011357 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 269796011358 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 269796011359 ligand binding site [chemical binding]; other site 269796011360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796011361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796011362 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 269796011363 active site 269796011364 substrate-binding site [chemical binding]; other site 269796011365 metal-binding site [ion binding] 269796011366 GTP binding site [chemical binding]; other site 269796011367 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 269796011368 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 269796011369 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 269796011370 Protein of unknown function (DUF461); Region: DUF461; pfam04314 269796011371 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796011372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796011373 active site 269796011374 phosphorylation site [posttranslational modification] 269796011375 intermolecular recognition site; other site 269796011376 dimerization interface [polypeptide binding]; other site 269796011377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269796011378 DNA binding site [nucleotide binding] 269796011379 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 269796011380 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 269796011381 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796011382 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796011383 dimerization interface [polypeptide binding]; other site 269796011384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796011385 dimer interface [polypeptide binding]; other site 269796011386 phosphorylation site [posttranslational modification] 269796011387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796011388 ATP binding site [chemical binding]; other site 269796011389 Mg2+ binding site [ion binding]; other site 269796011390 G-X-G motif; other site 269796011391 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 269796011392 active site 269796011393 dimer interface [polypeptide binding]; other site 269796011394 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 269796011395 active site 269796011396 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 269796011397 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 269796011398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796011399 catalytic residue [active] 269796011400 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 269796011401 substrate binding site [chemical binding]; other site 269796011402 active site 269796011403 catalytic residues [active] 269796011404 heterodimer interface [polypeptide binding]; other site 269796011405 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 269796011406 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 269796011407 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 269796011408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796011409 S-adenosylmethionine binding site [chemical binding]; other site 269796011410 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 269796011411 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 269796011412 catalytic residues [active] 269796011413 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 269796011414 Part of AAA domain; Region: AAA_19; pfam13245 269796011415 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 269796011416 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 269796011417 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 269796011418 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 269796011419 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 269796011420 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 269796011421 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 269796011422 Substrate binding site; other site 269796011423 metal-binding site 269796011424 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 269796011425 Phosphotransferase enzyme family; Region: APH; pfam01636 269796011426 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 269796011427 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 269796011428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796011429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269796011430 Predicted transcriptional regulators [Transcription]; Region: COG1695 269796011431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269796011432 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269796011433 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269796011434 PAS fold; Region: PAS_7; pfam12860 269796011435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796011436 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796011437 dimer interface [polypeptide binding]; other site 269796011438 phosphorylation site [posttranslational modification] 269796011439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796011440 ATP binding site [chemical binding]; other site 269796011441 Mg2+ binding site [ion binding]; other site 269796011442 G-X-G motif; other site 269796011443 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 269796011444 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 269796011445 homotetramer interface [polypeptide binding]; other site 269796011446 ligand binding site [chemical binding]; other site 269796011447 catalytic site [active] 269796011448 NAD binding site [chemical binding]; other site 269796011449 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 269796011450 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 269796011451 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 269796011452 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 269796011453 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 269796011454 dimerization domain swap beta strand [polypeptide binding]; other site 269796011455 regulatory protein interface [polypeptide binding]; other site 269796011456 active site 269796011457 regulatory phosphorylation site [posttranslational modification]; other site 269796011458 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 269796011459 active pocket/dimerization site; other site 269796011460 active site 269796011461 phosphorylation site [posttranslational modification] 269796011462 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 269796011463 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 269796011464 Hpr binding site; other site 269796011465 active site 269796011466 homohexamer subunit interaction site [polypeptide binding]; other site 269796011467 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 269796011468 CAS motifs; other site 269796011469 active site 269796011470 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 269796011471 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 269796011472 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 269796011473 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 269796011474 Walker A/P-loop; other site 269796011475 ATP binding site [chemical binding]; other site 269796011476 Q-loop/lid; other site 269796011477 ABC transporter signature motif; other site 269796011478 Walker B; other site 269796011479 D-loop; other site 269796011480 H-loop/switch region; other site 269796011481 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 269796011482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796011483 dimer interface [polypeptide binding]; other site 269796011484 conserved gate region; other site 269796011485 putative PBP binding loops; other site 269796011486 ABC-ATPase subunit interface; other site 269796011487 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 269796011488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269796011489 dimer interface [polypeptide binding]; other site 269796011490 conserved gate region; other site 269796011491 putative PBP binding loops; other site 269796011492 ABC-ATPase subunit interface; other site 269796011493 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 269796011494 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 269796011495 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 269796011496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269796011497 Coenzyme A binding pocket [chemical binding]; other site 269796011498 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 269796011499 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269796011500 ligand binding site [chemical binding]; other site 269796011501 flexible hinge region; other site 269796011502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796011503 TPR motif; other site 269796011504 Tetratricopeptide repeat; Region: TPR_12; pfam13424 269796011505 binding surface 269796011506 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 269796011507 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 269796011508 N- and C-terminal domain interface [polypeptide binding]; other site 269796011509 active site 269796011510 MgATP binding site [chemical binding]; other site 269796011511 catalytic site [active] 269796011512 metal binding site [ion binding]; metal-binding site 269796011513 glycerol binding site [chemical binding]; other site 269796011514 homotetramer interface [polypeptide binding]; other site 269796011515 homodimer interface [polypeptide binding]; other site 269796011516 FBP binding site [chemical binding]; other site 269796011517 protein IIAGlc interface [polypeptide binding]; other site 269796011518 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 269796011519 DNA-binding site [nucleotide binding]; DNA binding site 269796011520 RNA-binding motif; other site 269796011521 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 269796011522 DNA-binding site [nucleotide binding]; DNA binding site 269796011523 RNA-binding motif; other site 269796011524 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 269796011525 AsnC family; Region: AsnC_trans_reg; pfam01037 269796011526 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796011527 PAS fold; Region: PAS_3; pfam08447 269796011528 putative active site [active] 269796011529 heme pocket [chemical binding]; other site 269796011530 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796011531 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796011532 dimer interface [polypeptide binding]; other site 269796011533 putative CheW interface [polypeptide binding]; other site 269796011534 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 269796011535 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 269796011536 inhibitor-cofactor binding pocket; inhibition site 269796011537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796011538 catalytic residue [active] 269796011539 Amidinotransferase; Region: Amidinotransf; cl19186 269796011540 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 269796011541 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 269796011542 putative DNA binding site [nucleotide binding]; other site 269796011543 putative Zn2+ binding site [ion binding]; other site 269796011544 large tegument protein UL36; Provisional; Region: PHA03247 269796011545 recombination protein RecR; Reviewed; Region: recR; PRK00076 269796011546 RecR protein; Region: RecR; pfam02132 269796011547 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 269796011548 putative active site [active] 269796011549 putative metal-binding site [ion binding]; other site 269796011550 tetramer interface [polypeptide binding]; other site 269796011551 hypothetical protein; Validated; Region: PRK00153 269796011552 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 269796011553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796011554 Walker A motif; other site 269796011555 ATP binding site [chemical binding]; other site 269796011556 Walker B motif; other site 269796011557 arginine finger; other site 269796011558 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 269796011559 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 269796011560 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 269796011561 Ferritin-like domain; Region: Ferritin; pfam00210 269796011562 heme binding site [chemical binding]; other site 269796011563 ferroxidase pore; other site 269796011564 ferroxidase diiron center [ion binding]; other site 269796011565 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 269796011566 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269796011567 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269796011568 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 269796011569 putative effector binding pocket; other site 269796011570 dimerization interface [polypeptide binding]; other site 269796011571 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 269796011572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796011573 putative substrate translocation pore; other site 269796011574 PAS fold; Region: PAS_4; pfam08448 269796011575 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796011576 PAS domain; Region: PAS_9; pfam13426 269796011577 putative active site [active] 269796011578 heme pocket [chemical binding]; other site 269796011579 GAF domain; Region: GAF_3; pfam13492 269796011580 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796011581 metal binding site [ion binding]; metal-binding site 269796011582 active site 269796011583 I-site; other site 269796011584 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 269796011585 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 269796011586 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 269796011587 trimer interface [polypeptide binding]; other site 269796011588 active site 269796011589 substrate binding site [chemical binding]; other site 269796011590 CoA binding site [chemical binding]; other site 269796011591 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 269796011592 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 269796011593 metal binding site [ion binding]; metal-binding site 269796011594 dimer interface [polypeptide binding]; other site 269796011595 Transcriptional regulators [Transcription]; Region: MarR; COG1846 269796011596 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 269796011597 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 269796011598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796011599 putative substrate translocation pore; other site 269796011600 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 269796011601 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269796011602 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 269796011603 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796011604 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 269796011605 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 269796011606 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 269796011607 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 269796011608 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 269796011609 active site 269796011610 dimer interface [polypeptide binding]; other site 269796011611 motif 1; other site 269796011612 motif 2; other site 269796011613 motif 3; other site 269796011614 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 269796011615 anticodon binding site; other site 269796011616 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 269796011617 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 269796011618 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 269796011619 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 269796011620 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 269796011621 active site 269796011622 metal binding site [ion binding]; metal-binding site 269796011623 hexamer interface [polypeptide binding]; other site 269796011624 Cache domain; Region: Cache_1; pfam02743 269796011625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796011626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796011627 dimer interface [polypeptide binding]; other site 269796011628 phosphorylation site [posttranslational modification] 269796011629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796011630 ATP binding site [chemical binding]; other site 269796011631 Mg2+ binding site [ion binding]; other site 269796011632 G-X-G motif; other site 269796011633 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796011634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796011635 active site 269796011636 phosphorylation site [posttranslational modification] 269796011637 intermolecular recognition site; other site 269796011638 dimerization interface [polypeptide binding]; other site 269796011639 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 269796011640 putative binding surface; other site 269796011641 active site 269796011642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796011643 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796011644 active site 269796011645 phosphorylation site [posttranslational modification] 269796011646 intermolecular recognition site; other site 269796011647 dimerization interface [polypeptide binding]; other site 269796011648 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796011649 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 269796011650 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796011651 dimerization interface [polypeptide binding]; other site 269796011652 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796011653 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796011654 dimer interface [polypeptide binding]; other site 269796011655 putative CheW interface [polypeptide binding]; other site 269796011656 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 269796011657 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 269796011658 diiron binding motif [ion binding]; other site 269796011659 cobalt transport protein CbiM; Validated; Region: PRK06265 269796011660 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 269796011661 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 269796011662 Cytochrome C' Region: Cytochrom_C_2; cl01610 269796011663 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 269796011664 dimer interface [polypeptide binding]; other site 269796011665 ligand binding site [chemical binding]; other site 269796011666 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 269796011667 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269796011668 acyl-activating enzyme (AAE) consensus motif; other site 269796011669 AMP binding site [chemical binding]; other site 269796011670 active site 269796011671 CoA binding site [chemical binding]; other site 269796011672 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 269796011673 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 269796011674 Walker A/P-loop; other site 269796011675 ATP binding site [chemical binding]; other site 269796011676 Q-loop/lid; other site 269796011677 ABC transporter signature motif; other site 269796011678 Walker B; other site 269796011679 D-loop; other site 269796011680 H-loop/switch region; other site 269796011681 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 269796011682 putative ligand binding site [chemical binding]; other site 269796011683 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 269796011684 TM-ABC transporter signature motif; other site 269796011685 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 269796011686 TM-ABC transporter signature motif; other site 269796011687 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 269796011688 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 269796011689 acyl-activating enzyme (AAE) consensus motif; other site 269796011690 putative AMP binding site [chemical binding]; other site 269796011691 putative active site [active] 269796011692 putative CoA binding site [chemical binding]; other site 269796011693 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 269796011694 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 269796011695 Walker A/P-loop; other site 269796011696 ATP binding site [chemical binding]; other site 269796011697 Q-loop/lid; other site 269796011698 ABC transporter signature motif; other site 269796011699 Walker B; other site 269796011700 D-loop; other site 269796011701 H-loop/switch region; other site 269796011702 aconitate hydratase; Validated; Region: PRK09277 269796011703 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 269796011704 substrate binding site [chemical binding]; other site 269796011705 ligand binding site [chemical binding]; other site 269796011706 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 269796011707 substrate binding site [chemical binding]; other site 269796011708 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 269796011709 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 269796011710 catalytic triad [active] 269796011711 HAMP domain; Region: HAMP; pfam00672 269796011712 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796011713 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796011714 dimer interface [polypeptide binding]; other site 269796011715 putative CheW interface [polypeptide binding]; other site 269796011716 DNA polymerase I; Provisional; Region: PRK05755 269796011717 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 269796011718 active site 269796011719 metal binding site 1 [ion binding]; metal-binding site 269796011720 putative 5' ssDNA interaction site; other site 269796011721 metal binding site 3; metal-binding site 269796011722 metal binding site 2 [ion binding]; metal-binding site 269796011723 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 269796011724 putative DNA binding site [nucleotide binding]; other site 269796011725 putative metal binding site [ion binding]; other site 269796011726 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 269796011727 active site 269796011728 catalytic site [active] 269796011729 substrate binding site [chemical binding]; other site 269796011730 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 269796011731 active site 269796011732 DNA binding site [nucleotide binding] 269796011733 catalytic site [active] 269796011734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796011735 PAS domain; Region: PAS_9; pfam13426 269796011736 putative active site [active] 269796011737 heme pocket [chemical binding]; other site 269796011738 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 269796011739 LytTr DNA-binding domain; Region: LytTR; smart00850 269796011740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796011741 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269796011742 putative substrate translocation pore; other site 269796011743 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 269796011744 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 269796011745 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 269796011746 Transcriptional regulators [Transcription]; Region: MarR; COG1846 269796011747 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 269796011748 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 269796011749 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 269796011750 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 269796011751 23S rRNA binding site [nucleotide binding]; other site 269796011752 L21 binding site [polypeptide binding]; other site 269796011753 L13 binding site [polypeptide binding]; other site 269796011754 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 269796011755 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 269796011756 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 269796011757 dimer interface [polypeptide binding]; other site 269796011758 motif 1; other site 269796011759 active site 269796011760 motif 2; other site 269796011761 motif 3; other site 269796011762 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 269796011763 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 269796011764 putative tRNA-binding site [nucleotide binding]; other site 269796011765 B3/4 domain; Region: B3_4; pfam03483 269796011766 tRNA synthetase B5 domain; Region: B5; smart00874 269796011767 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 269796011768 dimer interface [polypeptide binding]; other site 269796011769 motif 1; other site 269796011770 motif 3; other site 269796011771 motif 2; other site 269796011772 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 269796011773 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 269796011774 YGGT family; Region: YGGT; pfam02325 269796011775 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 269796011776 TM-ABC transporter signature motif; other site 269796011777 DNA polymerase IV; Provisional; Region: PRK02794 269796011778 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 269796011779 active site 269796011780 DNA binding site [nucleotide binding] 269796011781 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 269796011782 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 269796011783 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 269796011784 Ligand Binding Site [chemical binding]; other site 269796011785 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 269796011786 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 269796011787 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 269796011788 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 269796011789 active site 269796011790 HIGH motif; other site 269796011791 dimer interface [polypeptide binding]; other site 269796011792 KMSKS motif; other site 269796011793 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 269796011794 putative FMN binding site [chemical binding]; other site 269796011795 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 269796011796 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 269796011797 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 269796011798 PII uridylyl-transferase; Provisional; Region: PRK05092 269796011799 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 269796011800 metal binding triad; other site 269796011801 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 269796011802 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269796011803 Zn2+ binding site [ion binding]; other site 269796011804 Mg2+ binding site [ion binding]; other site 269796011805 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 269796011806 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 269796011807 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 269796011808 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 269796011809 MutS domain I; Region: MutS_I; pfam01624 269796011810 MutS domain II; Region: MutS_II; pfam05188 269796011811 MutS domain III; Region: MutS_III; pfam05192 269796011812 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 269796011813 Walker A/P-loop; other site 269796011814 ATP binding site [chemical binding]; other site 269796011815 Q-loop/lid; other site 269796011816 ABC transporter signature motif; other site 269796011817 Walker B; other site 269796011818 D-loop; other site 269796011819 H-loop/switch region; other site 269796011820 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 269796011821 Malic enzyme, N-terminal domain; Region: malic; pfam00390 269796011822 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 269796011823 putative NAD(P) binding site [chemical binding]; other site 269796011824 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 269796011825 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 269796011826 PAS domain; Region: PAS_8; pfam13188 269796011827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796011828 dimer interface [polypeptide binding]; other site 269796011829 phosphorylation site [posttranslational modification] 269796011830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796011831 ATP binding site [chemical binding]; other site 269796011832 Mg2+ binding site [ion binding]; other site 269796011833 G-X-G motif; other site 269796011834 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 269796011835 PhoU domain; Region: PhoU; pfam01895 269796011836 PhoU domain; Region: PhoU; pfam01895 269796011837 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 269796011838 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 269796011839 anthranilate synthase; Provisional; Region: PRK13566 269796011840 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 269796011841 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 269796011842 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 269796011843 glutamine binding [chemical binding]; other site 269796011844 catalytic triad [active] 269796011845 Cysteine-rich small domain; Region: zf-like; cl00946 269796011846 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 269796011847 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 269796011848 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796011849 FeS/SAM binding site; other site 269796011850 cobyric acid synthase; Provisional; Region: PRK00784 269796011851 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796011852 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 269796011853 catalytic triad [active] 269796011854 cobyric acid synthase; Provisional; Region: PRK00784 269796011855 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 269796011856 catalytic triad [active] 269796011857 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 269796011858 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 269796011859 active site 269796011860 catalytic tetrad [active] 269796011861 CcdB protein; Region: CcdB; cl03380 269796011862 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 269796011863 chaperone protein DnaJ; Provisional; Region: PRK10767 269796011864 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 269796011865 HSP70 interaction site [polypeptide binding]; other site 269796011866 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 269796011867 substrate binding site [polypeptide binding]; other site 269796011868 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 269796011869 Zn binding sites [ion binding]; other site 269796011870 dimer interface [polypeptide binding]; other site 269796011871 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 269796011872 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 269796011873 nucleotide binding site [chemical binding]; other site 269796011874 NEF interaction site [polypeptide binding]; other site 269796011875 SBD interface [polypeptide binding]; other site 269796011876 Protein of unknown function (DUF1178); Region: DUF1178; cl17833 269796011877 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 269796011878 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 269796011879 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 269796011880 HSP70 interaction site [polypeptide binding]; other site 269796011881 PAS domain; Region: PAS_9; pfam13426 269796011882 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796011883 putative active site [active] 269796011884 heme pocket [chemical binding]; other site 269796011885 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 269796011886 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796011887 putative active site [active] 269796011888 heme pocket [chemical binding]; other site 269796011889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796011890 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 269796011891 putative active site [active] 269796011892 heme pocket [chemical binding]; other site 269796011893 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796011894 putative active site [active] 269796011895 heme pocket [chemical binding]; other site 269796011896 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269796011897 metal binding site [ion binding]; metal-binding site 269796011898 active site 269796011899 I-site; other site 269796011900 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269796011901 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269796011902 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269796011903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796011904 Walker A/P-loop; other site 269796011905 ATP binding site [chemical binding]; other site 269796011906 Q-loop/lid; other site 269796011907 ABC transporter signature motif; other site 269796011908 Walker B; other site 269796011909 D-loop; other site 269796011910 H-loop/switch region; other site 269796011911 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 269796011912 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269796011913 dimerization interface [polypeptide binding]; other site 269796011914 Predicted coiled-coil domain-containing protein (DUF2360); Region: DUF2360; pfam10152 269796011915 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796011916 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796011917 dimer interface [polypeptide binding]; other site 269796011918 putative CheW interface [polypeptide binding]; other site 269796011919 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 269796011920 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269796011921 active site 269796011922 motif I; other site 269796011923 motif II; other site 269796011924 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 269796011925 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 269796011926 HemY protein N-terminus; Region: HemY_N; pfam07219 269796011927 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 269796011928 active site 269796011929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 269796011930 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 269796011931 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 269796011932 domain interfaces; other site 269796011933 active site 269796011934 UGMP family protein; Validated; Region: PRK09604 269796011935 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 269796011936 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 269796011937 Domain of unknown function DUF29; Region: DUF29; pfam01724 269796011938 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 269796011939 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 269796011940 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 269796011941 YciI-like protein; Reviewed; Region: PRK12863 269796011942 EVE domain; Region: EVE; pfam01878 269796011943 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 269796011944 iron-sulfur cluster [ion binding]; other site 269796011945 [2Fe-2S] cluster binding site [ion binding]; other site 269796011946 acetyl-CoA synthetase; Provisional; Region: PRK00174 269796011947 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 269796011948 active site 269796011949 CoA binding site [chemical binding]; other site 269796011950 acyl-activating enzyme (AAE) consensus motif; other site 269796011951 AMP binding site [chemical binding]; other site 269796011952 acetate binding site [chemical binding]; other site 269796011953 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 269796011954 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 269796011955 putative NAD(P) binding site [chemical binding]; other site 269796011956 active site 269796011957 putative substrate binding site [chemical binding]; other site 269796011958 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 269796011959 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 269796011960 heat shock protein HtpX; Provisional; Region: PRK01345 269796011961 M48 family peptidase; Provisional; Region: PRK03001 269796011962 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269796011963 EamA-like transporter family; Region: EamA; pfam00892 269796011964 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 269796011965 aromatic arch; other site 269796011966 DCoH dimer interaction site [polypeptide binding]; other site 269796011967 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 269796011968 DCoH tetramer interaction site [polypeptide binding]; other site 269796011969 substrate binding site [chemical binding]; other site 269796011970 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 269796011971 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 269796011972 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 269796011973 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 269796011974 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 269796011975 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 269796011976 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 269796011977 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 269796011978 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 269796011979 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 269796011980 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 269796011981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796011982 Walker A motif; other site 269796011983 ATP binding site [chemical binding]; other site 269796011984 Walker B motif; other site 269796011985 arginine finger; other site 269796011986 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 269796011987 Methyltransferase domain; Region: Methyltransf_24; pfam13578 269796011988 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 269796011989 nucleotide binding site/active site [active] 269796011990 HIT family signature motif; other site 269796011991 catalytic residue [active] 269796011992 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 269796011993 metal binding site [ion binding]; metal-binding site 269796011994 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 269796011995 substrate binding site [chemical binding]; other site 269796011996 glutamase interaction surface [polypeptide binding]; other site 269796011997 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 269796011998 catalytic residues [active] 269796011999 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 269796012000 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 269796012001 putative active site [active] 269796012002 oxyanion strand; other site 269796012003 catalytic triad [active] 269796012004 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 269796012005 putative active site pocket [active] 269796012006 4-fold oligomerization interface [polypeptide binding]; other site 269796012007 metal binding residues [ion binding]; metal-binding site 269796012008 3-fold/trimer interface [polypeptide binding]; other site 269796012009 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269796012010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796012011 sequence-specific DNA binding site [nucleotide binding]; other site 269796012012 salt bridge; other site 269796012013 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 269796012014 active site 269796012015 HslU subunit interaction site [polypeptide binding]; other site 269796012016 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 269796012017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796012018 Walker A motif; other site 269796012019 ATP binding site [chemical binding]; other site 269796012020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269796012021 Walker B motif; other site 269796012022 arginine finger; other site 269796012023 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 269796012024 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269796012025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796012026 sequence-specific DNA binding site [nucleotide binding]; other site 269796012027 salt bridge; other site 269796012028 Smr domain; Region: Smr; pfam01713 269796012029 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 269796012030 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 269796012031 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 269796012032 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 269796012033 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 269796012034 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 269796012035 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 269796012036 Cysteine-rich domain; Region: CCG; pfam02754 269796012037 Cysteine-rich domain; Region: CCG; pfam02754 269796012038 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 269796012039 MltA specific insert domain; Region: MltA; smart00925 269796012040 3D domain; Region: 3D; pfam06725 269796012041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 269796012042 Tim44-like domain; Region: Tim44; pfam04280 269796012043 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 269796012044 preprotein translocase subunit SecB; Validated; Region: PRK05751 269796012045 SecA binding site; other site 269796012046 Preprotein binding site; other site 269796012047 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 269796012048 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 269796012049 active site 269796012050 catalytic site [active] 269796012051 substrate binding site [chemical binding]; other site 269796012052 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 269796012053 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 269796012054 CoA-binding site [chemical binding]; other site 269796012055 ATP-binding [chemical binding]; other site 269796012056 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 269796012057 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 269796012058 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 269796012059 shikimate binding site; other site 269796012060 NAD(P) binding site [chemical binding]; other site 269796012061 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 269796012062 active site 269796012063 dimer interface [polypeptide binding]; other site 269796012064 PEP synthetase regulatory protein; Provisional; Region: PRK05339 269796012065 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 269796012066 substrate binding site [chemical binding]; other site 269796012067 active site 269796012068 Ferrochelatase; Region: Ferrochelatase; pfam00762 269796012069 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 269796012070 C-terminal domain interface [polypeptide binding]; other site 269796012071 active site 269796012072 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 269796012073 active site 269796012074 N-terminal domain interface [polypeptide binding]; other site 269796012075 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 269796012076 transcription termination factor Rho; Provisional; Region: rho; PRK09376 269796012077 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 269796012078 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 269796012079 RNA binding site [nucleotide binding]; other site 269796012080 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 269796012081 multimer interface [polypeptide binding]; other site 269796012082 Walker A motif; other site 269796012083 ATP binding site [chemical binding]; other site 269796012084 Walker B motif; other site 269796012085 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 269796012086 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 269796012087 NADP binding site [chemical binding]; other site 269796012088 dimer interface [polypeptide binding]; other site 269796012089 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 269796012090 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 269796012091 DNA binding site [nucleotide binding] 269796012092 active site 269796012093 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 269796012094 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 269796012095 catalytic residues [active] 269796012096 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 269796012097 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 269796012098 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 269796012099 G4 box; other site 269796012100 GTP/Mg2+ binding site [chemical binding]; other site 269796012101 G5 box; other site 269796012102 trmE is a tRNA modification GTPase; Region: trmE; cd04164 269796012103 G1 box; other site 269796012104 G1 box; other site 269796012105 GTP/Mg2+ binding site [chemical binding]; other site 269796012106 Switch I region; other site 269796012107 Switch I region; other site 269796012108 G2 box; other site 269796012109 G2 box; other site 269796012110 Switch II region; other site 269796012111 G3 box; other site 269796012112 G3 box; other site 269796012113 Switch II region; other site 269796012114 G4 box; other site 269796012115 G5 box; other site 269796012116 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 269796012117 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 269796012118 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 269796012119 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 269796012120 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 269796012121 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 269796012122 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 269796012123 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796012124 P-loop; other site 269796012125 Magnesium ion binding site [ion binding]; other site 269796012126 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 269796012127 ParB-like nuclease domain; Region: ParB; smart00470 269796012128 KorB domain; Region: KorB; pfam08535 269796012129 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 269796012130 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 269796012131 Lipopolysaccharide-assembly; Region: LptE; pfam04390 269796012132 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 269796012133 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 269796012134 active site 269796012135 HIGH motif; other site 269796012136 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 269796012137 KMSKS motif; other site 269796012138 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 269796012139 tRNA binding surface [nucleotide binding]; other site 269796012140 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 269796012141 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 269796012142 thiamine phosphate binding site [chemical binding]; other site 269796012143 active site 269796012144 pyrophosphate binding site [ion binding]; other site 269796012145 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 269796012146 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 269796012147 catalytic residue [active] 269796012148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 269796012149 GTP cyclohydrolase; Provisional; Region: PRK08815 269796012150 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 269796012151 dimerization interface [polypeptide binding]; other site 269796012152 active site 269796012153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269796012154 cheY-homologous receiver domain; Region: REC; smart00448 269796012155 phosphorylation site [posttranslational modification] 269796012156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269796012157 DNA binding site [nucleotide binding] 269796012158 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 269796012159 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796012160 FeS/SAM binding site; other site 269796012161 HemN C-terminal domain; Region: HemN_C; pfam06969 269796012162 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 269796012163 active site 269796012164 dimerization interface [polypeptide binding]; other site 269796012165 ribonuclease PH; Reviewed; Region: rph; PRK00173 269796012166 Ribonuclease PH; Region: RNase_PH_bact; cd11362 269796012167 hexamer interface [polypeptide binding]; other site 269796012168 active site 269796012169 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 269796012170 HrcA protein C terminal domain; Region: HrcA; pfam01628 269796012171 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 269796012172 dimer interface [polypeptide binding]; other site 269796012173 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 269796012174 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 269796012175 putative uracil binding site [chemical binding]; other site 269796012176 putative active site [active] 269796012177 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 269796012178 NAD+ binding site [chemical binding]; other site 269796012179 substrate binding site [chemical binding]; other site 269796012180 Zn binding site [ion binding]; other site 269796012181 Low molecular weight phosphatase family; Region: LMWPc; cd00115 269796012182 active site 269796012183 Fructosamine kinase; Region: Fructosamin_kin; cl17579 269796012184 Phosphotransferase enzyme family; Region: APH; pfam01636 269796012185 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 269796012186 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 269796012187 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 269796012188 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 269796012189 active site 269796012190 catalytic triad [active] 269796012191 oxyanion hole [active] 269796012192 switch loop; other site 269796012193 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 269796012194 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 269796012195 Walker A/P-loop; other site 269796012196 ATP binding site [chemical binding]; other site 269796012197 Q-loop/lid; other site 269796012198 ABC transporter signature motif; other site 269796012199 Walker B; other site 269796012200 D-loop; other site 269796012201 H-loop/switch region; other site 269796012202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796012203 S-adenosylmethionine binding site [chemical binding]; other site 269796012204 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 269796012205 FtsX-like permease family; Region: FtsX; pfam02687 269796012206 FtsX-like permease family; Region: FtsX; pfam02687 269796012207 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 269796012208 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 269796012209 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 269796012210 purine monophosphate binding site [chemical binding]; other site 269796012211 dimer interface [polypeptide binding]; other site 269796012212 putative catalytic residues [active] 269796012213 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 269796012214 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 269796012215 CoA binding domain; Region: CoA_binding; cl17356 269796012216 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 269796012217 NAD(P) binding site [chemical binding]; other site 269796012218 homodimer interface [polypeptide binding]; other site 269796012219 substrate binding site [chemical binding]; other site 269796012220 active site 269796012221 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 269796012222 Mg++ binding site [ion binding]; other site 269796012223 putative catalytic motif [active] 269796012224 putative substrate binding site [chemical binding]; other site 269796012225 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 269796012226 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269796012227 putative ADP-binding pocket [chemical binding]; other site 269796012228 NusB family; Region: NusB; pfam01029 269796012229 16S rRNA methyltransferase B; Provisional; Region: PRK10901 269796012230 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cl03649 269796012231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796012232 S-adenosylmethionine binding site [chemical binding]; other site 269796012233 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 269796012234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269796012235 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 269796012236 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 269796012237 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 269796012238 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 269796012239 Walker A/P-loop; other site 269796012240 ATP binding site [chemical binding]; other site 269796012241 Q-loop/lid; other site 269796012242 ABC transporter signature motif; other site 269796012243 Walker B; other site 269796012244 D-loop; other site 269796012245 H-loop/switch region; other site 269796012246 CHASE3 domain; Region: CHASE3; pfam05227 269796012247 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269796012248 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 269796012249 dimer interface [polypeptide binding]; other site 269796012250 putative CheW interface [polypeptide binding]; other site 269796012251 oxidoreductase; Provisional; Region: PRK06128 269796012252 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 269796012253 NAD binding site [chemical binding]; other site 269796012254 metal binding site [ion binding]; metal-binding site 269796012255 active site 269796012256 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 269796012257 putative deacylase active site [active] 269796012258 hypothetical protein; Provisional; Region: PRK05208 269796012259 putative cation:proton antiport protein; Provisional; Region: PRK10669 269796012260 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 269796012261 TrkA-N domain; Region: TrkA_N; pfam02254 269796012262 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 269796012263 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 269796012264 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 269796012265 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 269796012266 Protein export membrane protein; Region: SecD_SecF; pfam02355 269796012267 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 269796012268 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 269796012269 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 269796012270 putative C-terminal domain interface [polypeptide binding]; other site 269796012271 putative GSH binding site (G-site) [chemical binding]; other site 269796012272 putative dimer interface [polypeptide binding]; other site 269796012273 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 269796012274 putative N-terminal domain interface [polypeptide binding]; other site 269796012275 putative dimer interface [polypeptide binding]; other site 269796012276 putative substrate binding pocket (H-site) [chemical binding]; other site 269796012277 DctM-like transporters; Region: DctM; pfam06808 269796012278 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 269796012279 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 269796012280 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 269796012281 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 269796012282 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 269796012283 Uncharacterized conserved protein [Function unknown]; Region: COG2353 269796012284 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 269796012285 YceI-like domain; Region: YceI; pfam04264 269796012286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796012287 TPR motif; other site 269796012288 binding surface 269796012289 TPR repeat; Region: TPR_11; pfam13414 269796012290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269796012291 binding surface 269796012292 TPR motif; other site 269796012293 TPR repeat; Region: TPR_11; pfam13414 269796012294 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 269796012295 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 269796012296 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269796012297 putative DNA binding site [nucleotide binding]; other site 269796012298 putative Zn2+ binding site [ion binding]; other site 269796012299 AsnC family; Region: AsnC_trans_reg; pfam01037 269796012300 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 269796012301 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 269796012302 hexamer interface [polypeptide binding]; other site 269796012303 ligand binding site [chemical binding]; other site 269796012304 putative active site [active] 269796012305 NAD(P) binding site [chemical binding]; other site 269796012306 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 269796012307 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 269796012308 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 269796012309 Walker A/P-loop; other site 269796012310 ATP binding site [chemical binding]; other site 269796012311 Q-loop/lid; other site 269796012312 ABC transporter signature motif; other site 269796012313 Walker B; other site 269796012314 D-loop; other site 269796012315 H-loop/switch region; other site 269796012316 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 269796012317 active site 269796012318 catalytic site [active] 269796012319 glutathione synthetase; Provisional; Region: PRK05246 269796012320 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 269796012321 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 269796012322 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 269796012323 BON domain; Region: BON; pfam04972 269796012324 hypothetical protein; Reviewed; Region: PRK12497 269796012325 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 269796012326 putative SAM binding site [chemical binding]; other site 269796012327 putative homodimer interface [polypeptide binding]; other site 269796012328 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 269796012329 putative ligand binding site [chemical binding]; other site 269796012330 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 269796012331 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 269796012332 acyl-activating enzyme (AAE) consensus motif; other site 269796012333 putative AMP binding site [chemical binding]; other site 269796012334 putative active site [active] 269796012335 putative CoA binding site [chemical binding]; other site 269796012336 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 269796012337 putative catalytic site [active] 269796012338 putative metal binding site [ion binding]; other site 269796012339 putative phosphate binding site [ion binding]; other site 269796012340 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 269796012341 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 269796012342 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 269796012343 multidrug efflux protein; Reviewed; Region: PRK09579 269796012344 MMPL family; Region: MMPL; cl14618 269796012345 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 269796012346 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269796012347 HlyD family secretion protein; Region: HlyD_3; pfam13437 269796012348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269796012349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269796012350 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 269796012351 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 269796012352 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 269796012353 ABC-ATPase subunit interface; other site 269796012354 dimer interface [polypeptide binding]; other site 269796012355 putative PBP binding regions; other site 269796012356 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 269796012357 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 269796012358 metal binding site [ion binding]; metal-binding site 269796012359 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 269796012360 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 269796012361 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 269796012362 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 269796012363 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 269796012364 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269796012365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796012366 homodimer interface [polypeptide binding]; other site 269796012367 catalytic residue [active] 269796012368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 269796012369 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 269796012370 Acyltransferase family; Region: Acyl_transf_3; pfam01757 269796012371 Uncharacterized conserved protein [Function unknown]; Region: COG2835 269796012372 ATP-dependent protease La (LON) domain; Region: LON; cl19481 269796012373 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 269796012374 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 269796012375 Tetratricopeptide repeat; Region: TPR_20; pfam14561 269796012376 LysE type translocator; Region: LysE; cl00565 269796012377 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 269796012378 Chain length determinant protein; Region: Wzz; pfam02706 269796012379 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 269796012380 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269796012381 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 269796012382 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 269796012383 SLBB domain; Region: SLBB; pfam10531 269796012384 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 269796012385 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 269796012386 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 269796012387 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 269796012388 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 269796012389 CoA binding domain; Region: CoA_binding; cl17356 269796012390 Bacterial sugar transferase; Region: Bac_transf; pfam02397 269796012391 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 269796012392 active site 269796012393 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 269796012394 CHAP domain; Region: CHAP; pfam05257 269796012395 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 269796012396 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 269796012397 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 269796012398 Walker A/P-loop; other site 269796012399 ATP binding site [chemical binding]; other site 269796012400 Q-loop/lid; other site 269796012401 ABC transporter signature motif; other site 269796012402 Walker B; other site 269796012403 D-loop; other site 269796012404 H-loop/switch region; other site 269796012405 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 269796012406 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 269796012407 Walker A/P-loop; other site 269796012408 ATP binding site [chemical binding]; other site 269796012409 Q-loop/lid; other site 269796012410 ABC transporter signature motif; other site 269796012411 Walker B; other site 269796012412 D-loop; other site 269796012413 H-loop/switch region; other site 269796012414 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 269796012415 TM-ABC transporter signature motif; other site 269796012416 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 269796012417 TM-ABC transporter signature motif; other site 269796012418 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 269796012419 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 269796012420 Creatinine amidohydrolase; Region: Creatininase; pfam02633 269796012421 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 269796012422 active site 269796012423 Transcriptional regulators [Transcription]; Region: GntR; COG1802 269796012424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 269796012425 DNA-binding site [nucleotide binding]; DNA binding site 269796012426 FCD domain; Region: FCD; pfam07729 269796012427 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 269796012428 active site 269796012429 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 269796012430 active site 269796012431 nucleotide binding site [chemical binding]; other site 269796012432 HIGH motif; other site 269796012433 KMSKS motif; other site 269796012434 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 269796012435 RES domain; Region: RES; smart00953 269796012436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 269796012437 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 269796012438 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 269796012439 active site 269796012440 DNA binding site [nucleotide binding] 269796012441 Int/Topo IB signature motif; other site 269796012442 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 269796012443 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 269796012444 ADP binding site [chemical binding]; other site 269796012445 magnesium binding site [ion binding]; other site 269796012446 putative shikimate binding site; other site 269796012447 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 269796012448 active site 269796012449 dimer interface [polypeptide binding]; other site 269796012450 metal binding site [ion binding]; metal-binding site 269796012451 FOG: CBS domain [General function prediction only]; Region: COG0517 269796012452 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 269796012453 Transporter associated domain; Region: CorC_HlyC; smart01091 269796012454 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 269796012455 FOG: CBS domain [General function prediction only]; Region: COG0517 269796012456 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 269796012457 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 269796012458 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 269796012459 5S rRNA interface [nucleotide binding]; other site 269796012460 CTC domain interface [polypeptide binding]; other site 269796012461 L16 interface [polypeptide binding]; other site 269796012462 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 269796012463 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 269796012464 putative active site [active] 269796012465 catalytic residue [active] 269796012466 GTP-binding protein YchF; Reviewed; Region: PRK09601 269796012467 YchF GTPase; Region: YchF; cd01900 269796012468 G1 box; other site 269796012469 GTP/Mg2+ binding site [chemical binding]; other site 269796012470 Switch I region; other site 269796012471 G2 box; other site 269796012472 Switch II region; other site 269796012473 G3 box; other site 269796012474 G4 box; other site 269796012475 G5 box; other site 269796012476 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 269796012477 Predicted ATPase [General function prediction only]; Region: COG4637 269796012478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269796012479 AAA domain; Region: AAA_21; pfam13304 269796012480 Walker A/P-loop; other site 269796012481 ATP binding site [chemical binding]; other site 269796012482 AAA domain; Region: AAA_21; pfam13304 269796012483 ABC transporter signature motif; other site 269796012484 Walker B; other site 269796012485 D-loop; other site 269796012486 H-loop/switch region; other site 269796012487 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 269796012488 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 269796012489 ANP binding site [chemical binding]; other site 269796012490 Substrate Binding Site II [chemical binding]; other site 269796012491 Substrate Binding Site I [chemical binding]; other site 269796012492 Domain of unknown function DUF302; Region: DUF302; pfam03625 269796012493 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 269796012494 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 269796012495 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 269796012496 putative dimer interface [polypeptide binding]; other site 269796012497 PAS fold; Region: PAS_4; pfam08448 269796012498 PAS domain S-box; Region: sensory_box; TIGR00229 269796012499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269796012500 putative active site [active] 269796012501 heme pocket [chemical binding]; other site 269796012502 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269796012503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269796012504 dimer interface [polypeptide binding]; other site 269796012505 phosphorylation site [posttranslational modification] 269796012506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269796012507 ATP binding site [chemical binding]; other site 269796012508 Mg2+ binding site [ion binding]; other site 269796012509 G-X-G motif; other site 269796012510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269796012511 active site 269796012512 phosphorylation site [posttranslational modification] 269796012513 intermolecular recognition site; other site 269796012514 dimerization interface [polypeptide binding]; other site 269796012515 Helix-turn-helix domain; Region: HTH_17; pfam12728 269796012516 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 269796012517 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 269796012518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 269796012519 DNA-binding site [nucleotide binding]; DNA binding site 269796012520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269796012521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796012522 homodimer interface [polypeptide binding]; other site 269796012523 catalytic residue [active] 269796012524 putative chaperone; Provisional; Region: PRK11678 269796012525 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 269796012526 nucleotide binding site [chemical binding]; other site 269796012527 putative NEF/HSP70 interaction site [polypeptide binding]; other site 269796012528 SBD interface [polypeptide binding]; other site 269796012529 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 269796012530 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 269796012531 Glycoprotease family; Region: Peptidase_M22; pfam00814 269796012532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269796012533 Coenzyme A binding pocket [chemical binding]; other site 269796012534 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 269796012535 CPxP motif; other site 269796012536 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 269796012537 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 269796012538 metal binding site 2 [ion binding]; metal-binding site 269796012539 putative DNA binding helix; other site 269796012540 metal binding site 1 [ion binding]; metal-binding site 269796012541 dimer interface [polypeptide binding]; other site 269796012542 structural Zn2+ binding site [ion binding]; other site 269796012543 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 269796012544 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 269796012545 putative acyl-acceptor binding pocket; other site 269796012546 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 269796012547 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 269796012548 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269796012549 FeS/SAM binding site; other site 269796012550 DEAD-like helicases superfamily; Region: DEXDc; smart00487 269796012551 PhoH-like protein; Region: PhoH; pfam02562 269796012552 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 269796012553 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 269796012554 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 269796012555 Transporter associated domain; Region: CorC_HlyC; smart01091 269796012556 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 269796012557 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 269796012558 putative active site [active] 269796012559 catalytic triad [active] 269796012560 putative dimer interface [polypeptide binding]; other site 269796012561 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269796012562 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269796012563 non-specific DNA binding site [nucleotide binding]; other site 269796012564 salt bridge; other site 269796012565 sequence-specific DNA binding site [nucleotide binding]; other site 269796012566 S-adenosylmethionine synthetase; Validated; Region: PRK05250 269796012567 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 269796012568 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 269796012569 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 269796012570 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 269796012571 Sm and related proteins; Region: Sm_like; cl00259 269796012572 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 269796012573 putative oligomer interface [polypeptide binding]; other site 269796012574 putative RNA binding site [nucleotide binding]; other site 269796012575 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 269796012576 NusA N-terminal domain; Region: NusA_N; pfam08529 269796012577 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 269796012578 RNA binding site [nucleotide binding]; other site 269796012579 homodimer interface [polypeptide binding]; other site 269796012580 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 269796012581 G-X-X-G motif; other site 269796012582 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 269796012583 G-X-X-G motif; other site 269796012584 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 269796012585 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 269796012586 hypothetical protein; Provisional; Region: PRK09190 269796012587 Protein of unknown function (DUF448); Region: DUF448; pfam04296 269796012588 putative RNA binding cleft [nucleotide binding]; other site 269796012589 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 269796012590 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 269796012591 translation initiation factor IF-2; Validated; Region: infB; PRK05306 269796012592 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 269796012593 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 269796012594 G1 box; other site 269796012595 putative GEF interaction site [polypeptide binding]; other site 269796012596 GTP/Mg2+ binding site [chemical binding]; other site 269796012597 Switch I region; other site 269796012598 G2 box; other site 269796012599 G3 box; other site 269796012600 Switch II region; other site 269796012601 G4 box; other site 269796012602 G5 box; other site 269796012603 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 269796012604 Translation-initiation factor 2; Region: IF-2; pfam11987 269796012605 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 269796012606 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 269796012607 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 269796012608 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 269796012609 RNA binding site [nucleotide binding]; other site 269796012610 active site 269796012611 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 269796012612 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 269796012613 16S/18S rRNA binding site [nucleotide binding]; other site 269796012614 S13e-L30e interaction site [polypeptide binding]; other site 269796012615 25S rRNA binding site [nucleotide binding]; other site 269796012616 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 269796012617 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 269796012618 RNase E interface [polypeptide binding]; other site 269796012619 trimer interface [polypeptide binding]; other site 269796012620 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 269796012621 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 269796012622 RNase E interface [polypeptide binding]; other site 269796012623 trimer interface [polypeptide binding]; other site 269796012624 active site 269796012625 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 269796012626 putative nucleic acid binding region [nucleotide binding]; other site 269796012627 G-X-X-G motif; other site 269796012628 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 269796012629 RNA binding site [nucleotide binding]; other site 269796012630 domain interface; other site 269796012631 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 269796012632 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 269796012633 active site 269796012634 catalytic site [active] 269796012635 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 269796012636 phosphate binding site [ion binding]; other site 269796012637 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 269796012638 metal binding site 2 [ion binding]; metal-binding site 269796012639 putative DNA binding helix; other site 269796012640 metal binding site 1 [ion binding]; metal-binding site 269796012641 dimer interface [polypeptide binding]; other site 269796012642 structural Zn2+ binding site [ion binding]; other site 269796012643 Bacterial SH3 domain; Region: SH3_4; pfam06347 269796012644 Bacterial SH3 domain; Region: SH3_4; pfam06347 269796012645 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 269796012646 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 269796012647 dimerization interface [polypeptide binding]; other site 269796012648 ligand binding site [chemical binding]; other site 269796012649 NADP binding site [chemical binding]; other site 269796012650 catalytic site [active] 269796012651 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 269796012652 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 269796012653 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 269796012654 ATP binding site [chemical binding]; other site 269796012655 substrate interface [chemical binding]; other site 269796012656 cysteine synthase; Region: PLN02565 269796012657 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 269796012658 dimer interface [polypeptide binding]; other site 269796012659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269796012660 catalytic residue [active] 269796012661 Predicted transcriptional regulator [Transcription]; Region: COG1959 269796012662 Rrf2 family protein; Region: rrf2_super; TIGR00738 269796012663 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 269796012664 Flavoprotein; Region: Flavoprotein; cl19190 269796012665 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 269796012666 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 269796012667 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 269796012668 active site 269796012669 ATP binding site [chemical binding]; other site 269796012670 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 269796012671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269796012672 S-adenosylmethionine binding site [chemical binding]; other site 269796012673 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 269796012674 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 269796012675 DNA binding site [nucleotide binding] 269796012676 catalytic residue [active] 269796012677 H2TH interface [polypeptide binding]; other site 269796012678 putative catalytic residues [active] 269796012679 turnover-facilitating residue; other site 269796012680 intercalation triad [nucleotide binding]; other site 269796012681 8OG recognition residue [nucleotide binding]; other site 269796012682 putative reading head residues; other site 269796012683 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 269796012684 enoyl-CoA hydratase; Provisional; Region: PRK05862 269796012685 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269796012686 substrate binding site [chemical binding]; other site 269796012687 oxyanion hole (OAH) forming residues; other site 269796012688 trimer interface [polypeptide binding]; other site 269796012689 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239