-- dump date 20140620_033216 -- class Genbank::misc_feature -- table misc_feature_note -- id note 518766000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 518766000002 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14088 518766000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766000004 Walker A motif; other site 518766000005 ATP binding site [chemical binding]; other site 518766000006 Walker B motif; other site 518766000007 arginine finger; other site 518766000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 518766000009 DnaA box-binding interface [nucleotide binding]; other site 518766000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 518766000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 518766000012 putative DNA binding surface [nucleotide binding]; other site 518766000013 dimer interface [polypeptide binding]; other site 518766000014 beta-clamp/clamp loader binding surface; other site 518766000015 beta-clamp/translesion DNA polymerase binding surface; other site 518766000016 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 518766000017 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 518766000018 DNA binding residues [nucleotide binding] 518766000019 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 518766000020 23S rRNA interface [nucleotide binding]; other site 518766000021 L3 interface [polypeptide binding]; other site 518766000022 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 518766000023 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 518766000024 rRNA interaction site [nucleotide binding]; other site 518766000025 S8 interaction site; other site 518766000026 putative laminin-1 binding site; other site 518766000027 elongation factor Ts; Provisional; Region: tsf; PRK09377 518766000028 UBA/TS-N domain; Region: UBA; pfam00627 518766000029 Elongation factor TS; Region: EF_TS; pfam00889 518766000030 Elongation factor TS; Region: EF_TS; pfam00889 518766000031 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 518766000032 putative nucleotide binding site [chemical binding]; other site 518766000033 uridine monophosphate binding site [chemical binding]; other site 518766000034 homohexameric interface [polypeptide binding]; other site 518766000035 ribosome recycling factor; Reviewed; Region: frr; PRK00083 518766000036 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 518766000037 hinge region; other site 518766000038 hypothetical protein; Provisional; Region: PRK11820 518766000039 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 518766000040 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 518766000041 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 518766000042 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 518766000043 catalytic site [active] 518766000044 G-X2-G-X-G-K; other site 518766000045 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 518766000046 Flavoprotein; Region: Flavoprotein; pfam02441 518766000047 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 518766000048 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 518766000049 Fe-S cluster binding site [ion binding]; other site 518766000050 active site 518766000051 replicative DNA helicase; Validated; Region: PRK07773 518766000052 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 518766000053 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 518766000054 Walker A motif; other site 518766000055 ATP binding site [chemical binding]; other site 518766000056 Walker B motif; other site 518766000057 DNA binding loops [nucleotide binding] 518766000058 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 518766000059 protein-splicing catalytic site; other site 518766000060 thioester formation/cholesterol transfer; other site 518766000061 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 518766000062 protein-splicing catalytic site; other site 518766000063 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 518766000064 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 518766000065 putative metal binding site [ion binding]; other site 518766000066 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 518766000067 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766000068 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 518766000069 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 518766000070 dimer interface [polypeptide binding]; other site 518766000071 active site residues [active] 518766000072 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 518766000073 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 518766000074 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 518766000075 ribosomal protein L33; Region: rpl33; CHL00104 518766000076 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 518766000077 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 518766000078 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 518766000079 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 518766000080 FtsX-like permease family; Region: FtsX; pfam02687 518766000081 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 518766000082 GTP-binding protein YchF; Reviewed; Region: PRK09601 518766000083 YchF GTPase; Region: YchF; cd01900 518766000084 G1 box; other site 518766000085 GTP/Mg2+ binding site [chemical binding]; other site 518766000086 Switch I region; other site 518766000087 G2 box; other site 518766000088 Switch II region; other site 518766000089 G3 box; other site 518766000090 G4 box; other site 518766000091 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 518766000092 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 518766000093 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 518766000094 active site 518766000095 metal binding site [ion binding]; metal-binding site 518766000096 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 518766000097 putative RNA binding site [nucleotide binding]; other site 518766000098 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 518766000099 Competence protein; Region: Competence; cl00471 518766000100 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 518766000101 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 518766000102 Ligand Binding Site [chemical binding]; other site 518766000103 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 518766000104 Ligand Binding Site [chemical binding]; other site 518766000105 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 518766000106 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 518766000107 active site 518766000108 dimer interface [polypeptide binding]; other site 518766000109 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 518766000110 dimer interface [polypeptide binding]; other site 518766000111 active site 518766000112 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 518766000113 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 518766000114 dimer interface [polypeptide binding]; other site 518766000115 putative functional site; other site 518766000116 putative MPT binding site; other site 518766000117 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 518766000118 putative catalytic residue [active] 518766000119 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 518766000120 active site 518766000121 Ap6A binding site [chemical binding]; other site 518766000122 nudix motif; other site 518766000123 metal binding site [ion binding]; metal-binding site 518766000124 Uncharacterized conserved protein [Function unknown]; Region: COG2850 518766000125 Cupin-like domain; Region: Cupin_8; pfam13621 518766000126 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 518766000127 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 518766000128 dimer interface [polypeptide binding]; other site 518766000129 ADP-ribose binding site [chemical binding]; other site 518766000130 active site 518766000131 nudix motif; other site 518766000132 metal binding site [ion binding]; metal-binding site 518766000133 Ion transport protein; Region: Ion_trans; pfam00520 518766000134 Ion channel; Region: Ion_trans_2; pfam07885 518766000135 Double zinc ribbon; Region: DZR; pfam12773 518766000136 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 518766000137 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 518766000138 putative uracil binding site [chemical binding]; other site 518766000139 putative active site [active] 518766000140 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 518766000141 FG-GAP repeat; Region: FG-GAP_2; pfam14312 518766000142 FG-GAP repeat; Region: FG-GAP_2; pfam14312 518766000143 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 518766000144 Protein of unknown function (DUF524); Region: DUF524; pfam04411 518766000145 EVE domain; Region: EVE; cl00728 518766000146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 518766000147 excinuclease ABC subunit B; Provisional; Region: PRK05298 518766000148 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 518766000149 ATP binding site [chemical binding]; other site 518766000150 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 518766000151 nucleotide binding region [chemical binding]; other site 518766000152 ATP-binding site [chemical binding]; other site 518766000153 Ultra-violet resistance protein B; Region: UvrB; pfam12344 518766000154 UvrB/uvrC motif; Region: UVR; pfam02151 518766000155 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 518766000156 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766000157 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 518766000158 DNA binding residues [nucleotide binding] 518766000159 FecR protein; Region: FecR; pfam04773 518766000160 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 518766000161 Secretin and TonB N terminus short domain; Region: STN; smart00965 518766000162 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766000163 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 518766000164 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 518766000165 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 518766000166 iron-sulfur cluster [ion binding]; other site 518766000167 [2Fe-2S] cluster binding site [ion binding]; other site 518766000168 YceI-like domain; Region: YceI; pfam04264 518766000169 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 518766000170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 518766000171 Walker A/P-loop; other site 518766000172 ATP binding site [chemical binding]; other site 518766000173 Q-loop/lid; other site 518766000174 ABC transporter signature motif; other site 518766000175 Walker B; other site 518766000176 D-loop; other site 518766000177 H-loop/switch region; other site 518766000178 TOBE domain; Region: TOBE; cl01440 518766000179 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 518766000180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 518766000181 dimer interface [polypeptide binding]; other site 518766000182 conserved gate region; other site 518766000183 putative PBP binding loops; other site 518766000184 ABC-ATPase subunit interface; other site 518766000185 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 518766000186 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 518766000187 Predicted transcriptional regulators [Transcription]; Region: COG1695 518766000188 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 518766000189 threonine synthase; Validated; Region: PRK08197 518766000190 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 518766000191 homodimer interface [polypeptide binding]; other site 518766000192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766000193 catalytic residue [active] 518766000194 Methyltransferase domain; Region: Methyltransf_23; pfam13489 518766000195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766000196 S-adenosylmethionine binding site [chemical binding]; other site 518766000197 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 518766000198 active site 518766000199 metal binding site [ion binding]; metal-binding site 518766000200 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 518766000201 Helix-turn-helix domain; Region: HTH_17; pfam12728 518766000202 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 518766000203 active site 518766000204 DNA binding site [nucleotide binding] 518766000205 Int/Topo IB signature motif; other site 518766000206 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 518766000207 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 518766000208 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 518766000209 HlyD family secretion protein; Region: HlyD_3; pfam13437 518766000210 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 518766000211 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 518766000212 Walker A/P-loop; other site 518766000213 ATP binding site [chemical binding]; other site 518766000214 Q-loop/lid; other site 518766000215 ABC transporter signature motif; other site 518766000216 Walker B; other site 518766000217 D-loop; other site 518766000218 H-loop/switch region; other site 518766000219 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 518766000220 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 518766000221 active site 518766000222 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 518766000223 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 518766000224 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 518766000225 catalytic residue [active] 518766000226 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 518766000227 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 518766000228 dimer interface [polypeptide binding]; other site 518766000229 putative CheW interface [polypeptide binding]; other site 518766000230 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 518766000231 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 518766000232 gamma subunit interface [polypeptide binding]; other site 518766000233 epsilon subunit interface [polypeptide binding]; other site 518766000234 LBP interface [polypeptide binding]; other site 518766000235 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 518766000236 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 518766000237 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 518766000238 alpha subunit interaction interface [polypeptide binding]; other site 518766000239 Walker A motif; other site 518766000240 ATP binding site [chemical binding]; other site 518766000241 Walker B motif; other site 518766000242 inhibitor binding site; inhibition site 518766000243 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 518766000244 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 518766000245 putative active site [active] 518766000246 Zn binding site [ion binding]; other site 518766000247 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 518766000248 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 518766000249 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 518766000250 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 518766000251 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 518766000252 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 518766000253 Ribosomal protein L31; Region: Ribosomal_L31; pfam01197 518766000254 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 518766000255 ThiC-associated domain; Region: ThiC-associated; pfam13667 518766000256 ThiC family; Region: ThiC; pfam01964 518766000257 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 518766000258 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 518766000259 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 518766000260 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 518766000261 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 518766000262 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 518766000263 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 518766000264 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 518766000265 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 518766000266 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 518766000267 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 518766000268 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 518766000269 active site 518766000270 catalytic tetrad [active] 518766000271 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 518766000272 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 518766000273 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 518766000274 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 518766000275 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 518766000276 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 518766000277 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 518766000278 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 518766000279 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 518766000280 substrate binding site [chemical binding]; other site 518766000281 oxyanion hole (OAH) forming residues; other site 518766000282 trimer interface [polypeptide binding]; other site 518766000283 Domain of unknown function DUF21; Region: DUF21; pfam01595 518766000284 FOG: CBS domain [General function prediction only]; Region: COG0517 518766000285 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 518766000286 Transporter associated domain; Region: CorC_HlyC; smart01091 518766000287 Uncharacterized conserved protein [Function unknown]; Region: COG2128 518766000288 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 518766000289 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 518766000290 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 518766000291 active site 518766000292 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766000293 citrate synthase; Provisional; Region: PRK14033 518766000294 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 518766000295 oxalacetate binding site [chemical binding]; other site 518766000296 citrylCoA binding site [chemical binding]; other site 518766000297 coenzyme A binding site [chemical binding]; other site 518766000298 catalytic triad [active] 518766000299 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 518766000300 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 518766000301 tetramer interface [polypeptide binding]; other site 518766000302 active site 518766000303 Mg2+/Mn2+ binding site [ion binding]; other site 518766000304 AAA domain; Region: AAA_26; pfam13500 518766000305 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 518766000306 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 518766000307 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 518766000308 inhibitor-cofactor binding pocket; inhibition site 518766000309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766000310 catalytic residue [active] 518766000311 hypothetical protein; Validated; Region: PRK06840 518766000312 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 518766000313 dimer interface [polypeptide binding]; other site 518766000314 active site 518766000315 CoA binding pocket [chemical binding]; other site 518766000316 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 518766000317 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 518766000318 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 518766000319 catalytic residue [active] 518766000320 biotin synthase; Region: bioB; TIGR00433 518766000321 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 518766000322 FeS/SAM binding site; other site 518766000323 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 518766000324 HTH domain; Region: HTH_11; cl17392 518766000325 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 518766000326 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 518766000327 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 518766000328 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 518766000329 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 518766000330 active site 518766000331 catalytic residues [active] 518766000332 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 518766000333 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 518766000334 nucleotide binding site [chemical binding]; other site 518766000335 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 518766000336 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 518766000337 active site 518766000338 Zn binding site [ion binding]; other site 518766000339 FOG: CBS domain [General function prediction only]; Region: COG0517 518766000340 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 518766000341 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 518766000342 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 518766000343 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 518766000344 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 518766000345 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 518766000346 potential catalytic triad [active] 518766000347 conserved cys residue [active] 518766000348 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 518766000349 DNA-binding site [nucleotide binding]; DNA binding site 518766000350 RNA-binding motif; other site 518766000351 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 518766000352 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 518766000353 Domain of unknown function (DUF4302); Region: DUF4302; pfam14135 518766000354 Trehalase; Region: Trehalase; cl17346 518766000355 trehalase; Provisional; Region: treF; PRK13270 518766000356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766000357 S-adenosylmethionine binding site [chemical binding]; other site 518766000358 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 518766000359 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 518766000360 putative NAD(P) binding site [chemical binding]; other site 518766000361 putative substrate binding site [chemical binding]; other site 518766000362 catalytic Zn binding site [ion binding]; other site 518766000363 structural Zn binding site [ion binding]; other site 518766000364 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 518766000365 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 518766000366 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 518766000367 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 518766000368 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 518766000369 protein binding site [polypeptide binding]; other site 518766000370 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 518766000371 Catalytic dyad [active] 518766000372 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 518766000373 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 518766000374 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 518766000375 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 518766000376 dimer interface [polypeptide binding]; other site 518766000377 active site 518766000378 glycine-pyridoxal phosphate binding site [chemical binding]; other site 518766000379 folate binding site [chemical binding]; other site 518766000380 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 518766000381 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 518766000382 Uncharacterized conserved protein [Function unknown]; Region: COG3342 518766000383 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 518766000384 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 518766000385 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 518766000386 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 518766000387 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 518766000388 NAD(P) binding site [chemical binding]; other site 518766000389 LDH/MDH dimer interface [polypeptide binding]; other site 518766000390 substrate binding site [chemical binding]; other site 518766000391 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 518766000392 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 518766000393 ATP-grasp domain; Region: ATP-grasp_4; cl17255 518766000394 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 518766000395 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 518766000396 FeS/SAM binding site; other site 518766000397 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 518766000398 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 518766000399 Cation transport protein; Region: TrkH; cl17365 518766000400 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 518766000401 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 518766000402 TrkA-N domain; Region: TrkA_N; pfam02254 518766000403 TrkA-C domain; Region: TrkA_C; pfam02080 518766000404 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 518766000405 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766000406 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 518766000407 Mechanosensitive ion channel; Region: MS_channel; pfam00924 518766000408 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 518766000409 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 518766000410 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766000411 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 518766000412 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 518766000413 DNA binding residues [nucleotide binding] 518766000414 GH3 auxin-responsive promoter; Region: GH3; pfam03321 518766000415 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 518766000416 dihydropteroate synthase; Region: DHPS; TIGR01496 518766000417 substrate binding pocket [chemical binding]; other site 518766000418 dimer interface [polypeptide binding]; other site 518766000419 inhibitor binding site; inhibition site 518766000420 Uncharacterized conserved protein [Function unknown]; Region: COG1624 518766000421 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 518766000422 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 518766000423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 518766000424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 518766000425 S-adenosylmethionine binding site [chemical binding]; other site 518766000426 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 518766000427 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 518766000428 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 518766000429 shikimate binding site; other site 518766000430 NAD(P) binding site [chemical binding]; other site 518766000431 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 518766000432 Putative transcription activator [Transcription]; Region: TenA; COG0819 518766000433 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 518766000434 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 518766000435 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 518766000436 ligand binding site [chemical binding]; other site 518766000437 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 518766000438 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 518766000439 putative NAD(P) binding site [chemical binding]; other site 518766000440 homodimer interface [polypeptide binding]; other site 518766000441 homotetramer interface [polypeptide binding]; other site 518766000442 active site 518766000443 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 518766000444 Domain of unknown function (DUF368); Region: DUF368; pfam04018 518766000445 TPR repeat; Region: TPR_11; pfam13414 518766000446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766000447 binding surface 518766000448 TPR motif; other site 518766000449 TPR repeat; Region: TPR_11; pfam13414 518766000450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766000451 binding surface 518766000452 TPR motif; other site 518766000453 TPR repeat; Region: TPR_11; pfam13414 518766000454 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766000455 binding surface 518766000456 TPR repeat; Region: TPR_11; pfam13414 518766000457 TPR motif; other site 518766000458 Tetratricopeptide repeat; Region: TPR_12; pfam13424 518766000459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766000460 binding surface 518766000461 TPR motif; other site 518766000462 TPR repeat; Region: TPR_11; pfam13414 518766000463 Tetratricopeptide repeat; Region: TPR_16; pfam13432 518766000464 thymidylate kinase; Validated; Region: tmk; PRK00698 518766000465 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 518766000466 TMP-binding site; other site 518766000467 ATP-binding site [chemical binding]; other site 518766000468 ferric uptake regulator; Provisional; Region: fur; PRK09462 518766000469 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 518766000470 metal binding site 2 [ion binding]; metal-binding site 518766000471 putative DNA binding helix; other site 518766000472 metal binding site 1 [ion binding]; metal-binding site 518766000473 dimer interface [polypeptide binding]; other site 518766000474 structural Zn2+ binding site [ion binding]; other site 518766000475 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 518766000476 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 518766000477 D-pathway; other site 518766000478 Low-spin heme binding site [chemical binding]; other site 518766000479 Putative water exit pathway; other site 518766000480 Binuclear center (active site) [active] 518766000481 K-pathway; other site 518766000482 Putative proton exit pathway; other site 518766000483 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 518766000484 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 518766000485 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 518766000486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 518766000487 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 518766000488 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 518766000489 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 518766000490 catalytic Zn binding site [ion binding]; other site 518766000491 NAD(P) binding site [chemical binding]; other site 518766000492 structural Zn binding site [ion binding]; other site 518766000493 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 518766000494 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 518766000495 active site 518766000496 catalytic tetrad [active] 518766000497 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 518766000498 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 518766000499 active site 518766000500 catalytic tetrad [active] 518766000501 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 518766000502 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 518766000503 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 518766000504 active site 518766000505 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 518766000506 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 518766000507 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 518766000508 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 518766000509 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 518766000510 dimerization interface [polypeptide binding]; other site 518766000511 ATP binding site [chemical binding]; other site 518766000512 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 518766000513 dimerization interface [polypeptide binding]; other site 518766000514 ATP binding site [chemical binding]; other site 518766000515 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 518766000516 catalytic residues [active] 518766000517 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 518766000518 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 518766000519 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 518766000520 BON domain; Region: BON; pfam04972 518766000521 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 518766000522 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 518766000523 Proline dehydrogenase; Region: Pro_dh; cl03282 518766000524 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 518766000525 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 518766000526 homodimer interface [polypeptide binding]; other site 518766000527 substrate-cofactor binding pocket; other site 518766000528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766000529 catalytic residue [active] 518766000530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766000531 putative active site [active] 518766000532 heme pocket [chemical binding]; other site 518766000533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766000534 PAS domain; Region: PAS_9; pfam13426 518766000535 putative active site [active] 518766000536 heme pocket [chemical binding]; other site 518766000537 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 518766000538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766000539 putative active site [active] 518766000540 heme pocket [chemical binding]; other site 518766000541 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766000542 dimer interface [polypeptide binding]; other site 518766000543 phosphorylation site [posttranslational modification] 518766000544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766000545 ATP binding site [chemical binding]; other site 518766000546 Mg2+ binding site [ion binding]; other site 518766000547 G-X-G motif; other site 518766000548 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 518766000549 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 518766000550 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 518766000551 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 518766000552 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 518766000553 active site residue [active] 518766000554 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 518766000555 active site residue [active] 518766000556 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 518766000557 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 518766000558 CoA-binding site [chemical binding]; other site 518766000559 ATP-binding [chemical binding]; other site 518766000560 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 518766000561 nucleotide binding site/active site [active] 518766000562 HIT family signature motif; other site 518766000563 catalytic residue [active] 518766000564 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 518766000565 active site 518766000566 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 518766000567 homodecamer interface [polypeptide binding]; other site 518766000568 GTP cyclohydrolase I; Provisional; Region: PLN03044 518766000569 active site 518766000570 putative catalytic site residues [active] 518766000571 zinc binding site [ion binding]; other site 518766000572 GTP-CH-I/GFRP interaction surface; other site 518766000573 short chain dehydrogenase; Provisional; Region: PRK07454 518766000574 classical (c) SDRs; Region: SDR_c; cd05233 518766000575 NAD(P) binding site [chemical binding]; other site 518766000576 active site 518766000577 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 518766000578 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 518766000579 active site 518766000580 PAS fold; Region: PAS_4; pfam08448 518766000581 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766000582 putative active site [active] 518766000583 PAS fold; Region: PAS; pfam00989 518766000584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766000585 putative active site [active] 518766000586 heme pocket [chemical binding]; other site 518766000587 hypothetical protein; Validated; Region: PRK00228 518766000588 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 518766000589 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 518766000590 active site 518766000591 catalytic tetrad [active] 518766000592 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 518766000593 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766000594 type III secretion system chaperone YscW; Region: YscW; TIGR02567 518766000595 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 518766000596 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 518766000597 Dehydroquinase class II; Region: DHquinase_II; pfam01220 518766000598 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 518766000599 active site 518766000600 trimer interface [polypeptide binding]; other site 518766000601 dimer interface [polypeptide binding]; other site 518766000602 putative hydrolase; Provisional; Region: PRK02113 518766000603 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 518766000604 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 518766000605 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 518766000606 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 518766000607 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 518766000608 putative Iron-sulfur protein interface [polypeptide binding]; other site 518766000609 putative proximal heme binding site [chemical binding]; other site 518766000610 putative SdhD-like interface [polypeptide binding]; other site 518766000611 putative distal heme binding site [chemical binding]; other site 518766000612 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 518766000613 putative Iron-sulfur protein interface [polypeptide binding]; other site 518766000614 putative proximal heme binding site [chemical binding]; other site 518766000615 putative SdhC-like subunit interface [polypeptide binding]; other site 518766000616 putative distal heme binding site [chemical binding]; other site 518766000617 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 518766000618 L-aspartate oxidase; Provisional; Region: PRK06175 518766000619 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 518766000620 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 518766000621 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 518766000622 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 518766000623 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 518766000624 putative active site pocket [active] 518766000625 dimerization interface [polypeptide binding]; other site 518766000626 putative catalytic residue [active] 518766000627 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 518766000628 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 518766000629 N-acetyl-D-glucosamine binding site [chemical binding]; other site 518766000630 catalytic residue [active] 518766000631 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 518766000632 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 518766000633 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 518766000634 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 518766000635 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 518766000636 nicotinate-nucleotide diphosphorylase (carboxylating); Region: PLN02716 518766000637 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 518766000638 dimerization interface [polypeptide binding]; other site 518766000639 active site 518766000640 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 518766000641 active site 518766000642 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 518766000643 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 518766000644 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 518766000645 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 518766000646 Probable Catalytic site; other site 518766000647 metal-binding site 518766000648 CoA-binding domain; Region: CoA_binding_3; pfam13727 518766000649 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 518766000650 heme-binding residues [chemical binding]; other site 518766000651 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 518766000652 molybdopterin cofactor binding site; other site 518766000653 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 518766000654 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 518766000655 4Fe-4S binding domain; Region: Fer4; cl02805 518766000656 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 518766000657 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 518766000658 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 518766000659 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 518766000660 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 518766000661 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 518766000662 Cu(I) binding site [ion binding]; other site 518766000663 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 518766000664 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 518766000665 Cytochrome c; Region: Cytochrom_C; pfam00034 518766000666 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 518766000667 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 518766000668 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 518766000669 Subunit I/III interface [polypeptide binding]; other site 518766000670 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 518766000671 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 518766000672 FAD binding site [chemical binding]; other site 518766000673 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 518766000674 DNA-binding site [nucleotide binding]; DNA binding site 518766000675 RNA-binding motif; other site 518766000676 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 518766000677 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 518766000678 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 518766000679 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 518766000680 putative active site [active] 518766000681 Predicted methyltransferases [General function prediction only]; Region: COG0313 518766000682 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 518766000683 putative SAM binding site [chemical binding]; other site 518766000684 putative homodimer interface [polypeptide binding]; other site 518766000685 Predicted permeases [General function prediction only]; Region: COG0795 518766000686 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 518766000687 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 518766000688 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 518766000689 phosphodiesterase YaeI; Provisional; Region: PRK11340 518766000690 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 518766000691 putative active site [active] 518766000692 putative metal binding site [ion binding]; other site 518766000693 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 518766000694 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 518766000695 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 518766000696 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 518766000697 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 518766000698 putative catalytic site [active] 518766000699 putative phosphate binding site [ion binding]; other site 518766000700 putative metal binding site [ion binding]; other site 518766000701 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 518766000702 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766000703 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766000704 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 518766000705 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 518766000706 ligand binding site [chemical binding]; other site 518766000707 NAD binding site [chemical binding]; other site 518766000708 catalytic site [active] 518766000709 homodimer interface [polypeptide binding]; other site 518766000710 GTPase Era; Reviewed; Region: era; PRK00089 518766000711 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 518766000712 G1 box; other site 518766000713 GTP/Mg2+ binding site [chemical binding]; other site 518766000714 Switch I region; other site 518766000715 G2 box; other site 518766000716 Switch II region; other site 518766000717 G3 box; other site 518766000718 G4 box; other site 518766000719 G5 box; other site 518766000720 KH domain; Region: KH_2; pfam07650 518766000721 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 518766000722 active site 518766000723 hydrophilic channel; other site 518766000724 dimerization interface [polypeptide binding]; other site 518766000725 catalytic residues [active] 518766000726 active site lid [active] 518766000727 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 518766000728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766000729 S-adenosylmethionine binding site [chemical binding]; other site 518766000730 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 518766000731 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 518766000732 active site 518766000733 (T/H)XGH motif; other site 518766000734 aspartate aminotransferase; Provisional; Region: PRK05764 518766000735 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 518766000736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766000737 homodimer interface [polypeptide binding]; other site 518766000738 catalytic residue [active] 518766000739 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 518766000740 Peptidase family M50; Region: Peptidase_M50; pfam02163 518766000741 active site 518766000742 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 518766000743 putative substrate binding region [chemical binding]; other site 518766000744 BNR repeat-like domain; Region: BNR_2; pfam13088 518766000745 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 518766000746 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 518766000747 active site residue [active] 518766000748 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 518766000749 active site residue [active] 518766000750 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 518766000751 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 518766000752 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 518766000753 catalytic residues [active] 518766000754 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 518766000755 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 518766000756 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 518766000757 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 518766000758 active site residue [active] 518766000759 Sulphur transport; Region: Sulf_transp; pfam04143 518766000760 Predicted transporter component [General function prediction only]; Region: COG2391 518766000761 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 518766000762 dimerization interface [polypeptide binding]; other site 518766000763 putative DNA binding site [nucleotide binding]; other site 518766000764 putative Zn2+ binding site [ion binding]; other site 518766000765 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 518766000766 active site 518766000767 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 518766000768 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766000769 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766000770 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 518766000771 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 518766000772 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 518766000773 active site 518766000774 metal binding site [ion binding]; metal-binding site 518766000775 DNA binding site [nucleotide binding] 518766000776 Transglycosylase; Region: Transgly; pfam00912 518766000777 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 518766000778 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 518766000779 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 518766000780 putative active site [active] 518766000781 putative metal binding site [ion binding]; other site 518766000782 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 518766000783 Rhomboid family; Region: Rhomboid; pfam01694 518766000784 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 518766000785 GcpE protein; Region: GcpE; pfam04551 518766000786 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 518766000787 Transcriptional regulators [Transcription]; Region: PurR; COG1609 518766000788 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 518766000789 DNA binding site [nucleotide binding] 518766000790 domain linker motif; other site 518766000791 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 518766000792 dimerization interface [polypeptide binding]; other site 518766000793 ligand binding site [chemical binding]; other site 518766000794 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 518766000795 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 518766000796 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 518766000797 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 518766000798 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766000799 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 518766000800 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 518766000801 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766000802 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 518766000803 starch-binding site 1 [chemical binding]; other site 518766000804 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766000805 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 518766000806 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 518766000807 active site 518766000808 catalytic site [active] 518766000809 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766000810 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 518766000811 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 518766000812 active site 518766000813 homodimer interface [polypeptide binding]; other site 518766000814 catalytic site [active] 518766000815 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 518766000816 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 518766000817 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 518766000818 GAF domain; Region: GAF; cl17456 518766000819 GAF domain; Region: GAF; cl17456 518766000820 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 518766000821 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 518766000822 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 518766000823 active site 518766000824 metal binding site [ion binding]; metal-binding site 518766000825 homotetramer interface [polypeptide binding]; other site 518766000826 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 518766000827 metal-dependent hydrolase; Provisional; Region: PRK00685 518766000828 Protein of unknown function (DUF433); Region: DUF433; pfam04255 518766000829 Predicted membrane protein [Function unknown]; Region: COG1297 518766000830 putative oligopeptide transporter, OPT family; Region: TIGR00733 518766000831 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 518766000832 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766000833 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 518766000834 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 518766000835 dimerization interface [polypeptide binding]; other site 518766000836 allosteric effector site; other site 518766000837 active site 518766000838 ADP/pyrophosphate binding site [chemical binding]; other site 518766000839 fructose-1,6-bisphosphate binding site; other site 518766000840 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 518766000841 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 518766000842 putative NAD(P) binding site [chemical binding]; other site 518766000843 active site 518766000844 Rossmann-like domain; Region: Rossmann-like; pfam10727 518766000845 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 518766000846 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 518766000847 active site 518766000848 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 518766000849 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 518766000850 dimer interface [polypeptide binding]; other site 518766000851 putative anticodon binding site; other site 518766000852 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 518766000853 motif 1; other site 518766000854 active site 518766000855 motif 2; other site 518766000856 motif 3; other site 518766000857 H+ Antiporter protein; Region: 2A0121; TIGR00900 518766000858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 518766000859 putative substrate translocation pore; other site 518766000860 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 518766000861 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 518766000862 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 518766000863 FOG: PKD repeat [General function prediction only]; Region: COG3291 518766000864 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 518766000865 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 518766000866 ligand binding site [chemical binding]; other site 518766000867 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 518766000868 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 518766000869 Peptidase family M23; Region: Peptidase_M23; pfam01551 518766000870 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 518766000871 ATP synthase A chain; Region: ATP-synt_A; cl00413 518766000872 ATP synthase subunit C; Region: ATP-synt_C; cl00466 518766000873 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 518766000874 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 518766000875 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 518766000876 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 518766000877 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 518766000878 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 518766000879 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 518766000880 beta subunit interaction interface [polypeptide binding]; other site 518766000881 Walker A motif; other site 518766000882 ATP binding site [chemical binding]; other site 518766000883 Walker B motif; other site 518766000884 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 518766000885 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 518766000886 core domain interface [polypeptide binding]; other site 518766000887 delta subunit interface [polypeptide binding]; other site 518766000888 epsilon subunit interface [polypeptide binding]; other site 518766000889 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 518766000890 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 518766000891 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 518766000892 Part of AAA domain; Region: AAA_19; pfam13245 518766000893 Family description; Region: UvrD_C_2; pfam13538 518766000894 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 518766000895 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 518766000896 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 518766000897 FeS/SAM binding site; other site 518766000898 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 518766000899 Ligand Binding Site [chemical binding]; other site 518766000900 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 518766000901 active site 518766000902 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 518766000903 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 518766000904 Dynamin family; Region: Dynamin_N; pfam00350 518766000905 G1 box; other site 518766000906 GTP/Mg2+ binding site [chemical binding]; other site 518766000907 G2 box; other site 518766000908 Switch I region; other site 518766000909 G3 box; other site 518766000910 Switch II region; other site 518766000911 G4 box; other site 518766000912 G5 box; other site 518766000913 recombination factor protein RarA; Reviewed; Region: PRK13342 518766000914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766000915 Walker A motif; other site 518766000916 ATP binding site [chemical binding]; other site 518766000917 Walker B motif; other site 518766000918 arginine finger; other site 518766000919 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 518766000920 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 518766000921 6-phosphogluconate dehydratase; Region: edd; TIGR01196 518766000922 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 518766000923 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 518766000924 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 518766000925 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 518766000926 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 518766000927 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 518766000928 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 518766000929 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 518766000930 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766000931 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 518766000932 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766000933 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 518766000934 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 518766000935 active site 518766000936 dimer interface [polypeptide binding]; other site 518766000937 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 518766000938 intracellular protease, PfpI family; Region: PfpI; TIGR01382 518766000939 conserved cys residue [active] 518766000940 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 518766000941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 518766000942 FeS/SAM binding site; other site 518766000943 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 518766000944 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 518766000945 TPP-binding site [chemical binding]; other site 518766000946 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 518766000947 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 518766000948 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 518766000949 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 518766000950 dimer interface [polypeptide binding]; other site 518766000951 PYR/PP interface [polypeptide binding]; other site 518766000952 TPP binding site [chemical binding]; other site 518766000953 substrate binding site [chemical binding]; other site 518766000954 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 518766000955 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 518766000956 thymidylate synthase; Reviewed; Region: thyA; PRK01827 518766000957 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 518766000958 dimerization interface [polypeptide binding]; other site 518766000959 active site 518766000960 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 518766000961 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 518766000962 folate binding site [chemical binding]; other site 518766000963 NADP+ binding site [chemical binding]; other site 518766000964 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 518766000965 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 518766000966 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 518766000967 active site 518766000968 dimer interface [polypeptide binding]; other site 518766000969 effector binding site; other site 518766000970 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 518766000971 Two component regulator propeller; Region: Reg_prop; pfam07494 518766000972 Two component regulator propeller; Region: Reg_prop; pfam07494 518766000973 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 518766000974 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 518766000975 dimerization interface [polypeptide binding]; other site 518766000976 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 518766000977 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 518766000978 dimer interface [polypeptide binding]; other site 518766000979 putative CheW interface [polypeptide binding]; other site 518766000980 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 518766000981 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 518766000982 amidohydrolase; Region: amidohydrolases; TIGR01891 518766000983 putative metal binding site [ion binding]; other site 518766000984 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 518766000985 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 518766000986 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 518766000987 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 518766000988 putative active site [active] 518766000989 putative metal binding site [ion binding]; other site 518766000990 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 518766000991 EamA-like transporter family; Region: EamA; pfam00892 518766000992 EamA-like transporter family; Region: EamA; pfam00892 518766000993 Transcriptional regulators [Transcription]; Region: PurR; COG1609 518766000994 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 518766000995 DNA binding site [nucleotide binding] 518766000996 domain linker motif; other site 518766000997 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 518766000998 dimerization interface [polypeptide binding]; other site 518766000999 ligand binding site [chemical binding]; other site 518766001000 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 518766001001 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766001002 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766001003 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 518766001004 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766001005 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 518766001006 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 518766001007 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 518766001008 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 518766001009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 518766001010 dimer interface [polypeptide binding]; other site 518766001011 conserved gate region; other site 518766001012 putative PBP binding loops; other site 518766001013 ABC-ATPase subunit interface; other site 518766001014 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 518766001015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 518766001016 dimer interface [polypeptide binding]; other site 518766001017 conserved gate region; other site 518766001018 ABC-ATPase subunit interface; other site 518766001019 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 518766001020 active site 518766001021 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 518766001022 active site 518766001023 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 518766001024 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 518766001025 Walker A/P-loop; other site 518766001026 ATP binding site [chemical binding]; other site 518766001027 Q-loop/lid; other site 518766001028 ABC transporter signature motif; other site 518766001029 Walker B; other site 518766001030 D-loop; other site 518766001031 H-loop/switch region; other site 518766001032 TOBE domain; Region: TOBE_2; pfam08402 518766001033 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 518766001034 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 518766001035 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 518766001036 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 518766001037 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 518766001038 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 518766001039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 518766001040 nucleotide binding region [chemical binding]; other site 518766001041 ATP-binding site [chemical binding]; other site 518766001042 SEC-C motif; Region: SEC-C; pfam02810 518766001043 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 518766001044 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 518766001045 Walker A/P-loop; other site 518766001046 ATP binding site [chemical binding]; other site 518766001047 Q-loop/lid; other site 518766001048 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 518766001049 ABC transporter signature motif; other site 518766001050 Walker B; other site 518766001051 D-loop; other site 518766001052 H-loop/switch region; other site 518766001053 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 518766001054 GAF domain; Region: GAF_2; pfam13185 518766001055 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 518766001056 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 518766001057 active site 518766001058 substrate binding site [chemical binding]; other site 518766001059 metal binding site [ion binding]; metal-binding site 518766001060 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 518766001061 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 518766001062 Low molecular weight phosphatase family; Region: LMWPc; cd00115 518766001063 active site 518766001064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 518766001065 Coenzyme A binding pocket [chemical binding]; other site 518766001066 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 518766001067 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 518766001068 metal binding site [ion binding]; metal-binding site 518766001069 dimer interface [polypeptide binding]; other site 518766001070 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 518766001071 Protein of unknown function (DUF328); Region: DUF328; pfam03883 518766001072 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 518766001073 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 518766001074 ATP-binding site [chemical binding]; other site 518766001075 Sugar specificity; other site 518766001076 Pyrimidine base specificity; other site 518766001077 Type III pantothenate kinase; Region: Pan_kinase; cl17198 518766001078 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 518766001079 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 518766001080 active site 518766001081 dimerization interface [polypeptide binding]; other site 518766001082 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 518766001083 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 518766001084 NAD binding site [chemical binding]; other site 518766001085 homotetramer interface [polypeptide binding]; other site 518766001086 homodimer interface [polypeptide binding]; other site 518766001087 substrate binding site [chemical binding]; other site 518766001088 active site 518766001089 Peptidase family M1; Region: Peptidase_M1; pfam01433 518766001090 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 518766001091 Zn binding site [ion binding]; other site 518766001092 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 518766001093 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 518766001094 Src Homology 3 domain superfamily; Region: SH3; cl17036 518766001095 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 518766001096 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 518766001097 Methyltransferase domain; Region: Methyltransf_23; pfam13489 518766001098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766001099 S-adenosylmethionine binding site [chemical binding]; other site 518766001100 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 518766001101 dimer interface [polypeptide binding]; other site 518766001102 active site residues [active] 518766001103 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 518766001104 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 518766001105 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 518766001106 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 518766001107 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 518766001108 Nucleoside recognition; Region: Gate; pfam07670 518766001109 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 518766001110 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 518766001111 Zn binding site [ion binding]; other site 518766001112 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 518766001113 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 518766001114 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 518766001115 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 518766001116 Part of AAA domain; Region: AAA_19; pfam13245 518766001117 Family description; Region: UvrD_C_2; pfam13538 518766001118 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 518766001119 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 518766001120 hypothetical protein; Provisional; Region: PRK11770 518766001121 Domain of unknown function (DUF307); Region: DUF307; pfam03733 518766001122 Domain of unknown function (DUF307); Region: DUF307; pfam03733 518766001123 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 518766001124 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 518766001125 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 518766001126 FMN binding site [chemical binding]; other site 518766001127 active site 518766001128 catalytic residues [active] 518766001129 substrate binding site [chemical binding]; other site 518766001130 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 518766001131 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 518766001132 active site 518766001133 DNA binding site [nucleotide binding] 518766001134 Int/Topo IB signature motif; other site 518766001135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766001136 S-adenosylmethionine binding site [chemical binding]; other site 518766001137 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 518766001138 Recombination protein O N terminal; Region: RecO_N; pfam11967 518766001139 Recombination protein O C terminal; Region: RecO_C; pfam02565 518766001140 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 518766001141 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 518766001142 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 518766001143 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 518766001144 Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928 518766001145 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 518766001146 nudix motif; other site 518766001147 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 518766001148 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 518766001149 [4Fe-4S] binding site [ion binding]; other site 518766001150 molybdopterin cofactor binding site; other site 518766001151 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 518766001152 molybdopterin cofactor binding site; other site 518766001153 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 518766001154 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 518766001155 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 518766001156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 518766001157 Walker A/P-loop; other site 518766001158 ATP binding site [chemical binding]; other site 518766001159 Q-loop/lid; other site 518766001160 ABC transporter signature motif; other site 518766001161 Walker B; other site 518766001162 D-loop; other site 518766001163 H-loop/switch region; other site 518766001164 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 518766001165 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 518766001166 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 518766001167 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 518766001168 Walker A/P-loop; other site 518766001169 ATP binding site [chemical binding]; other site 518766001170 Q-loop/lid; other site 518766001171 ABC transporter signature motif; other site 518766001172 Walker B; other site 518766001173 D-loop; other site 518766001174 H-loop/switch region; other site 518766001175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 518766001176 putative DNA binding site [nucleotide binding]; other site 518766001177 dimerization interface [polypeptide binding]; other site 518766001178 putative Zn2+ binding site [ion binding]; other site 518766001179 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 518766001180 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 518766001181 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 518766001182 active site 518766001183 metal binding site [ion binding]; metal-binding site 518766001184 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 518766001185 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 518766001186 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 518766001187 Metal-binding active site; metal-binding site 518766001188 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 518766001189 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 518766001190 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 518766001191 active site 518766001192 phosphorylation site [posttranslational modification] 518766001193 TrkA-C domain; Region: TrkA_C; pfam02080 518766001194 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 518766001195 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 518766001196 THF binding site; other site 518766001197 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 518766001198 substrate binding site [chemical binding]; other site 518766001199 THF binding site; other site 518766001200 zinc-binding site [ion binding]; other site 518766001201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 518766001202 Protein of unknown function (DUF433); Region: DUF433; pfam04255 518766001203 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 518766001204 dimer interface [polypeptide binding]; other site 518766001205 putative radical transfer pathway; other site 518766001206 diiron center [ion binding]; other site 518766001207 tyrosyl radical; other site 518766001208 ATP cone domain; Region: ATP-cone; pfam03477 518766001209 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 518766001210 ATP cone domain; Region: ATP-cone; pfam03477 518766001211 Class I ribonucleotide reductase; Region: RNR_I; cd01679 518766001212 active site 518766001213 dimer interface [polypeptide binding]; other site 518766001214 catalytic residues [active] 518766001215 effector binding site; other site 518766001216 R2 peptide binding site; other site 518766001217 YceI-like domain; Region: YceI; pfam04264 518766001218 YceI-like domain; Region: YceI; pfam04264 518766001219 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 518766001220 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 518766001221 nucleotide binding site [chemical binding]; other site 518766001222 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 518766001223 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 518766001224 Oxygen tolerance; Region: BatD; pfam13584 518766001225 von Willebrand factor type A domain; Region: VWA_2; pfam13519 518766001226 metal ion-dependent adhesion site (MIDAS); other site 518766001227 Aerotolerance regulator N-terminal; Region: BatA; cl06567 518766001228 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 518766001229 metal ion-dependent adhesion site (MIDAS); other site 518766001230 Protein of unknown function (DUF493); Region: DUF493; pfam04359 518766001231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766001232 active site 518766001233 phosphorylation site [posttranslational modification] 518766001234 intermolecular recognition site; other site 518766001235 dimerization interface [polypeptide binding]; other site 518766001236 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 518766001237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 518766001238 motif II; other site 518766001239 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 518766001240 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 518766001241 substrate-cofactor binding pocket; other site 518766001242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766001243 catalytic residue [active] 518766001244 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 518766001245 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 518766001246 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 518766001247 ParB-like nuclease domain; Region: ParBc; pfam02195 518766001248 KorB domain; Region: KorB; pfam08535 518766001249 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 518766001250 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 518766001251 P-loop; other site 518766001252 Magnesium ion binding site [ion binding]; other site 518766001253 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 518766001254 Magnesium ion binding site [ion binding]; other site 518766001255 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 518766001256 Part of AAA domain; Region: AAA_19; pfam13245 518766001257 Family description; Region: UvrD_C_2; pfam13538 518766001258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 518766001259 Coenzyme A binding pocket [chemical binding]; other site 518766001260 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 518766001261 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 518766001262 FtsX-like permease family; Region: FtsX; pfam02687 518766001263 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 518766001264 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 518766001265 FtsX-like permease family; Region: FtsX; pfam02687 518766001266 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 518766001267 tetramer (dimer of dimers) interface [polypeptide binding]; other site 518766001268 active site 518766001269 dimer interface [polypeptide binding]; other site 518766001270 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 518766001271 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 518766001272 putative carbohydrate kinase; Provisional; Region: PRK10565 518766001273 Uncharacterized conserved protein [Function unknown]; Region: COG0062 518766001274 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 518766001275 putative substrate binding site [chemical binding]; other site 518766001276 putative ATP binding site [chemical binding]; other site 518766001277 Bacterial Ig-like domain; Region: Big_5; pfam13205 518766001278 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766001279 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 518766001280 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 518766001281 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 518766001282 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 518766001283 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 518766001284 hexamer interface [polypeptide binding]; other site 518766001285 ligand binding site [chemical binding]; other site 518766001286 putative active site [active] 518766001287 NAD(P) binding site [chemical binding]; other site 518766001288 Transcriptional regulators [Transcription]; Region: PurR; COG1609 518766001289 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 518766001290 DNA binding site [nucleotide binding] 518766001291 domain linker motif; other site 518766001292 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 518766001293 ligand binding site [chemical binding]; other site 518766001294 dimerization interface [polypeptide binding]; other site 518766001295 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 518766001296 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 518766001297 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 518766001298 hexamer (dimer of trimers) interface [polypeptide binding]; other site 518766001299 substrate binding site [chemical binding]; other site 518766001300 trimer interface [polypeptide binding]; other site 518766001301 Mn binding site [ion binding]; other site 518766001302 ribulokinase; Provisional; Region: PRK04123 518766001303 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 518766001304 N- and C-terminal domain interface [polypeptide binding]; other site 518766001305 active site 518766001306 MgATP binding site [chemical binding]; other site 518766001307 catalytic site [active] 518766001308 metal binding site [ion binding]; metal-binding site 518766001309 carbohydrate binding site [chemical binding]; other site 518766001310 homodimer interface [polypeptide binding]; other site 518766001311 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 518766001312 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 518766001313 intersubunit interface [polypeptide binding]; other site 518766001314 active site 518766001315 Zn2+ binding site [ion binding]; other site 518766001316 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 518766001317 Na binding site [ion binding]; other site 518766001318 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 518766001319 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 518766001320 TPP-binding site [chemical binding]; other site 518766001321 dimer interface [polypeptide binding]; other site 518766001322 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 518766001323 PYR/PP interface [polypeptide binding]; other site 518766001324 dimer interface [polypeptide binding]; other site 518766001325 TPP binding site [chemical binding]; other site 518766001326 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 518766001327 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 518766001328 active site 518766001329 intersubunit interactions; other site 518766001330 catalytic residue [active] 518766001331 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 518766001332 active site 518766001333 catalytic residues [active] 518766001334 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 518766001335 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 518766001336 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 518766001337 Transcriptional regulators [Transcription]; Region: PurR; COG1609 518766001338 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 518766001339 DNA binding site [nucleotide binding] 518766001340 domain linker motif; other site 518766001341 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 518766001342 dimerization interface [polypeptide binding]; other site 518766001343 ligand binding site [chemical binding]; other site 518766001344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 518766001345 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 518766001346 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 518766001347 active site 518766001348 catalytic site [active] 518766001349 substrate binding site [chemical binding]; other site 518766001350 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 518766001351 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 518766001352 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 518766001353 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 518766001354 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 518766001355 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 518766001356 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 518766001357 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497 518766001358 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 518766001359 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cl08187 518766001360 DinB family; Region: DinB; cl17821 518766001361 DinB superfamily; Region: DinB_2; pfam12867 518766001362 galactokinase; Region: gal_kin; TIGR00131 518766001363 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 518766001364 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 518766001365 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 518766001366 putative transporter; Provisional; Region: PRK10484 518766001367 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 518766001368 Na binding site [ion binding]; other site 518766001369 substrate binding site [chemical binding]; other site 518766001370 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 518766001371 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 518766001372 dimer interface [polypeptide binding]; other site 518766001373 active site 518766001374 Protein of unknown function, DUF486; Region: DUF486; cl01236 518766001375 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 518766001376 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 518766001377 inhibitor site; inhibition site 518766001378 active site 518766001379 dimer interface [polypeptide binding]; other site 518766001380 catalytic residue [active] 518766001381 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 518766001382 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 518766001383 NAD(P) binding site [chemical binding]; other site 518766001384 catalytic residues [active] 518766001385 Transcriptional regulators [Transcription]; Region: GntR; COG1802 518766001386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 518766001387 DNA-binding site [nucleotide binding]; DNA binding site 518766001388 FCD domain; Region: FCD; pfam07729 518766001389 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 518766001390 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 518766001391 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 518766001392 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 518766001393 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 518766001394 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 518766001395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 518766001396 motif II; other site 518766001397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 518766001398 mannosyl-3-phosphoglycerate synthase; Provisional; Region: PRK14503 518766001399 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth); Region: Osmo_MPGsynth; pfam09488 518766001400 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 518766001401 Trehalase; Region: Trehalase; cl17346 518766001402 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 518766001403 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 518766001404 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 518766001405 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 518766001406 protein-splicing catalytic site; other site 518766001407 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 518766001408 Kelch motif; Region: Kelch_1; pfam01344 518766001409 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 518766001410 Kelch motif; Region: Kelch_1; pfam01344 518766001411 Kelch motif; Region: Kelch_1; pfam01344 518766001412 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 518766001413 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 518766001414 Catalytic domain of Protein Kinases; Region: PKc; cd00180 518766001415 active site 518766001416 ATP binding site [chemical binding]; other site 518766001417 substrate binding site [chemical binding]; other site 518766001418 activation loop (A-loop); other site 518766001419 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 518766001420 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 518766001421 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 518766001422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766001423 Walker A motif; other site 518766001424 ATP binding site [chemical binding]; other site 518766001425 Walker B motif; other site 518766001426 arginine finger; other site 518766001427 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 518766001428 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766001429 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 518766001430 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 518766001431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766001432 dimer interface [polypeptide binding]; other site 518766001433 phosphorylation site [posttranslational modification] 518766001434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766001435 ATP binding site [chemical binding]; other site 518766001436 Mg2+ binding site [ion binding]; other site 518766001437 G-X-G motif; other site 518766001438 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 518766001439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766001440 active site 518766001441 phosphorylation site [posttranslational modification] 518766001442 intermolecular recognition site; other site 518766001443 dimerization interface [polypeptide binding]; other site 518766001444 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 518766001445 DNA binding site [nucleotide binding] 518766001446 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 518766001447 HlyD family secretion protein; Region: HlyD_3; pfam13437 518766001448 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 518766001449 Outer membrane efflux protein; Region: OEP; pfam02321 518766001450 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 518766001451 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 518766001452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 518766001453 Walker A/P-loop; other site 518766001454 ATP binding site [chemical binding]; other site 518766001455 Q-loop/lid; other site 518766001456 ABC transporter signature motif; other site 518766001457 Walker B; other site 518766001458 D-loop; other site 518766001459 H-loop/switch region; other site 518766001460 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 518766001461 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 518766001462 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 518766001463 metal-binding site [ion binding] 518766001464 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 518766001465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 518766001466 motif II; other site 518766001467 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 518766001468 Alkaline phosphatase homologues; Region: alkPPc; smart00098 518766001469 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 518766001470 active site 518766001471 dimer interface [polypeptide binding]; other site 518766001472 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 518766001473 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 518766001474 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 518766001475 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 518766001476 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 518766001477 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 518766001478 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 518766001479 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 518766001480 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 518766001481 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 518766001482 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 518766001483 FAD binding domain; Region: FAD_binding_4; pfam01565 518766001484 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 518766001485 probable regulatory domain; Region: near_KaiC_dom; TIGR03879 518766001486 KaiC domain protein, AF_0795 family; Region: thermo_KaiC_2; TIGR03878 518766001487 KaiC; Region: KaiC; pfam06745 518766001488 Walker A motif; other site 518766001489 ATP binding site [chemical binding]; other site 518766001490 Walker B motif; other site 518766001491 Predicted methyltransferases [General function prediction only]; Region: COG1568 518766001492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766001493 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 518766001494 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 518766001495 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 518766001496 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 518766001497 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 518766001498 TMAO/DMSO reductase; Reviewed; Region: PRK05363 518766001499 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 518766001500 Moco binding site; other site 518766001501 metal coordination site [ion binding]; other site 518766001502 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 518766001503 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 518766001504 active site 518766001505 catalytic triad [active] 518766001506 oxyanion hole [active] 518766001507 switch loop; other site 518766001508 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 518766001509 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 518766001510 Walker A/P-loop; other site 518766001511 ATP binding site [chemical binding]; other site 518766001512 Q-loop/lid; other site 518766001513 ABC transporter signature motif; other site 518766001514 Walker B; other site 518766001515 D-loop; other site 518766001516 H-loop/switch region; other site 518766001517 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 518766001518 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 518766001519 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 518766001520 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 518766001521 metal binding site [ion binding]; metal-binding site 518766001522 dimer interface [polypeptide binding]; other site 518766001523 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 518766001524 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 518766001525 PA/protease or protease-like domain interface [polypeptide binding]; other site 518766001526 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 518766001527 Peptidase family M28; Region: Peptidase_M28; pfam04389 518766001528 metal binding site [ion binding]; metal-binding site 518766001529 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 518766001530 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 518766001531 metal ion-dependent adhesion site (MIDAS); other site 518766001532 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 518766001533 active site 518766001534 NTP binding site [chemical binding]; other site 518766001535 metal binding triad [ion binding]; metal-binding site 518766001536 antibiotic binding site [chemical binding]; other site 518766001537 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 518766001538 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 518766001539 putative active site [active] 518766001540 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 518766001541 active site 518766001542 NTP binding site [chemical binding]; other site 518766001543 metal binding triad [ion binding]; metal-binding site 518766001544 antibiotic binding site [chemical binding]; other site 518766001545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 518766001546 active site 518766001547 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 518766001548 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 518766001549 ATP-binding site [chemical binding]; other site 518766001550 Gluconate-6-phosphate binding site [chemical binding]; other site 518766001551 Shikimate kinase; Region: SKI; pfam01202 518766001552 GntP family permease; Region: GntP_permease; pfam02447 518766001553 fructuronate transporter; Provisional; Region: PRK10034; cl15264 518766001554 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 518766001555 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 518766001556 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 518766001557 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 518766001558 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 518766001559 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 518766001560 Walker A motif; other site 518766001561 ATP binding site [chemical binding]; other site 518766001562 Walker B motif; other site 518766001563 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 518766001564 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 518766001565 ATP binding site [chemical binding]; other site 518766001566 Walker B motif; other site 518766001567 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 518766001568 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 518766001569 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 518766001570 metal binding site [ion binding]; metal-binding site 518766001571 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 518766001572 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 518766001573 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 518766001574 putative acyl-acceptor binding pocket; other site 518766001575 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 518766001576 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 518766001577 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 518766001578 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 518766001579 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 518766001580 homodimer interface [polypeptide binding]; other site 518766001581 active site 518766001582 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 518766001583 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766001584 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 518766001585 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 518766001586 active site 518766001587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766001588 S-adenosylmethionine binding site [chemical binding]; other site 518766001589 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 518766001590 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 518766001591 catalytic core [active] 518766001592 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 518766001593 chorismate binding enzyme; Region: Chorismate_bind; cl10555 518766001594 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 518766001595 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 518766001596 dimer interface [polypeptide binding]; other site 518766001597 tetramer interface [polypeptide binding]; other site 518766001598 PYR/PP interface [polypeptide binding]; other site 518766001599 TPP binding site [chemical binding]; other site 518766001600 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 518766001601 TPP-binding site; other site 518766001602 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 518766001603 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 518766001604 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 518766001605 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 518766001606 catalytic loop [active] 518766001607 iron binding site [ion binding]; other site 518766001608 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 518766001609 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 518766001610 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 518766001611 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 518766001612 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 518766001613 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 518766001614 UbiA prenyltransferase family; Region: UbiA; pfam01040 518766001615 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 518766001616 active site 518766001617 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 518766001618 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 518766001619 acyl-activating enzyme (AAE) consensus motif; other site 518766001620 putative AMP binding site [chemical binding]; other site 518766001621 putative active site [active] 518766001622 putative CoA binding site [chemical binding]; other site 518766001623 Response regulator receiver domain; Region: Response_reg; pfam00072 518766001624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766001625 active site 518766001626 phosphorylation site [posttranslational modification] 518766001627 intermolecular recognition site; other site 518766001628 dimerization interface [polypeptide binding]; other site 518766001629 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 518766001630 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 518766001631 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 518766001632 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 518766001633 anti sigma factor interaction site; other site 518766001634 regulatory phosphorylation site [posttranslational modification]; other site 518766001635 B3/4 domain; Region: B3_4; pfam03483 518766001636 OstA-like protein; Region: OstA; cl00844 518766001637 OstA-like protein; Region: OstA; cl00844 518766001638 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 518766001639 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 518766001640 Walker A/P-loop; other site 518766001641 ATP binding site [chemical binding]; other site 518766001642 Q-loop/lid; other site 518766001643 ABC transporter signature motif; other site 518766001644 Walker B; other site 518766001645 D-loop; other site 518766001646 H-loop/switch region; other site 518766001647 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 518766001648 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 518766001649 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 518766001650 Ligand Binding Site [chemical binding]; other site 518766001651 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 518766001652 active site residue [active] 518766001653 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 518766001654 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 518766001655 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 518766001656 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 518766001657 glutaminase active site [active] 518766001658 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 518766001659 dimer interface [polypeptide binding]; other site 518766001660 active site 518766001661 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 518766001662 dimer interface [polypeptide binding]; other site 518766001663 active site 518766001664 peptide chain release factor 1; Validated; Region: prfA; PRK00591 518766001665 This domain is found in peptide chain release factors; Region: PCRF; smart00937 518766001666 RF-1 domain; Region: RF-1; pfam00472 518766001667 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 518766001668 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 518766001669 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 518766001670 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 518766001671 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 518766001672 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 518766001673 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 518766001674 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 518766001675 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 518766001676 Major Facilitator Superfamily; Region: MFS_1; pfam07690 518766001677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 518766001678 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 518766001679 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 518766001680 ABC-ATPase subunit interface; other site 518766001681 dimer interface [polypeptide binding]; other site 518766001682 putative PBP binding regions; other site 518766001683 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 518766001684 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 518766001685 intersubunit interface [polypeptide binding]; other site 518766001686 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 518766001687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766001688 active site 518766001689 phosphorylation site [posttranslational modification] 518766001690 intermolecular recognition site; other site 518766001691 dimerization interface [polypeptide binding]; other site 518766001692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766001693 Walker A motif; other site 518766001694 ATP binding site [chemical binding]; other site 518766001695 Walker B motif; other site 518766001696 arginine finger; other site 518766001697 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 518766001698 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 518766001699 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 518766001700 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 518766001701 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 518766001702 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 518766001703 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 518766001704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 518766001705 DNA binding site [nucleotide binding] 518766001706 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 518766001707 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 518766001708 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 518766001709 Zn2+ binding site [ion binding]; other site 518766001710 Mg2+ binding site [ion binding]; other site 518766001711 Cell division protein ZapA; Region: ZapA; pfam05164 518766001712 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 518766001713 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 518766001714 putative tRNA-binding site [nucleotide binding]; other site 518766001715 B3/4 domain; Region: B3_4; pfam03483 518766001716 tRNA synthetase B5 domain; Region: B5; smart00874 518766001717 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 518766001718 dimer interface [polypeptide binding]; other site 518766001719 motif 1; other site 518766001720 motif 3; other site 518766001721 motif 2; other site 518766001722 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 518766001723 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 518766001724 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 518766001725 dimer interface [polypeptide binding]; other site 518766001726 motif 1; other site 518766001727 active site 518766001728 motif 2; other site 518766001729 motif 3; other site 518766001730 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 518766001731 23S rRNA binding site [nucleotide binding]; other site 518766001732 L21 binding site [polypeptide binding]; other site 518766001733 L13 binding site [polypeptide binding]; other site 518766001734 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 518766001735 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 518766001736 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 518766001737 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 518766001738 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 518766001739 active site 518766001740 dimer interface [polypeptide binding]; other site 518766001741 motif 1; other site 518766001742 motif 2; other site 518766001743 motif 3; other site 518766001744 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 518766001745 anticodon binding site; other site 518766001746 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 518766001747 putative ligand binding site [chemical binding]; other site 518766001748 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 518766001749 Active_site [active] 518766001750 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 518766001751 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 518766001752 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 518766001753 acyl-activating enzyme (AAE) consensus motif; other site 518766001754 putative AMP binding site [chemical binding]; other site 518766001755 putative active site [active] 518766001756 putative CoA binding site [chemical binding]; other site 518766001757 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 518766001758 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 518766001759 quinone interaction residues [chemical binding]; other site 518766001760 active site 518766001761 catalytic residues [active] 518766001762 FMN binding site [chemical binding]; other site 518766001763 substrate binding site [chemical binding]; other site 518766001764 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 518766001765 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 518766001766 PQQ-like domain; Region: PQQ_2; pfam13360 518766001767 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 518766001768 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766001769 Surface antigen; Region: Bac_surface_Ag; pfam01103 518766001770 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 518766001771 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 518766001772 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 518766001773 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 518766001774 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 518766001775 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 518766001776 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 518766001777 active site 518766001778 HIGH motif; other site 518766001779 KMSK motif region; other site 518766001780 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 518766001781 tRNA binding surface [nucleotide binding]; other site 518766001782 anticodon binding site; other site 518766001783 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 518766001784 Prephenate dehydratase; Region: PDT; pfam00800 518766001785 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 518766001786 putative L-Phe binding site [chemical binding]; other site 518766001787 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 518766001788 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 518766001789 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 518766001790 Na binding site [ion binding]; other site 518766001791 Uncharacterized conserved protein [Function unknown]; Region: COG3595 518766001792 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 518766001793 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 518766001794 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 518766001795 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 518766001796 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 518766001797 Walker A/P-loop; other site 518766001798 ATP binding site [chemical binding]; other site 518766001799 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 518766001800 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 518766001801 ABC transporter signature motif; other site 518766001802 Walker B; other site 518766001803 D-loop; other site 518766001804 H-loop/switch region; other site 518766001805 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 518766001806 HlyD family secretion protein; Region: HlyD_3; pfam13437 518766001807 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 518766001808 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 518766001809 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 518766001810 Protein export membrane protein; Region: SecD_SecF; cl14618 518766001811 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 518766001812 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 518766001813 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 518766001814 HEAT repeats; Region: HEAT_2; pfam13646 518766001815 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 518766001816 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 518766001817 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 518766001818 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 518766001819 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766001820 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 518766001821 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926 518766001822 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 518766001823 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 518766001824 active site 518766001825 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 518766001826 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766001827 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 518766001828 DNA binding residues [nucleotide binding] 518766001829 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 518766001830 FecR protein; Region: FecR; pfam04773 518766001831 Secretin and TonB N terminus short domain; Region: STN; smart00965 518766001832 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766001833 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766001834 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 518766001835 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 518766001836 RecX family; Region: RecX; cl00936 518766001837 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 518766001838 Domain of unknown function DUF20; Region: UPF0118; pfam01594 518766001839 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 518766001840 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 518766001841 purine nucleoside phosphorylase; Provisional; Region: PRK08202 518766001842 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 518766001843 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 518766001844 histidinol dehydrogenase; Region: hisD; TIGR00069 518766001845 NAD binding site [chemical binding]; other site 518766001846 dimerization interface [polypeptide binding]; other site 518766001847 product binding site; other site 518766001848 substrate binding site [chemical binding]; other site 518766001849 zinc binding site [ion binding]; other site 518766001850 catalytic residues [active] 518766001851 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 518766001852 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 518766001853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766001854 homodimer interface [polypeptide binding]; other site 518766001855 catalytic residue [active] 518766001856 Bifunctional nuclease; Region: DNase-RNase; pfam02577 518766001857 UvrB/uvrC motif; Region: UVR; pfam02151 518766001858 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 518766001859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 518766001860 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 518766001861 HD domain; Region: HD_4; pfam13328 518766001862 aminoacyl-tRNA ligase; Region: PLN02563 518766001863 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 518766001864 HIGH motif; other site 518766001865 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 518766001866 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 518766001867 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 518766001868 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 518766001869 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 518766001870 active site 518766001871 KMSKS motif; other site 518766001872 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 518766001873 tRNA binding surface [nucleotide binding]; other site 518766001874 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 518766001875 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 518766001876 elongation factor P; Validated; Region: PRK00529 518766001877 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 518766001878 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 518766001879 RNA binding site [nucleotide binding]; other site 518766001880 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 518766001881 RNA binding site [nucleotide binding]; other site 518766001882 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 518766001883 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 518766001884 carboxyltransferase (CT) interaction site; other site 518766001885 biotinylation site [posttranslational modification]; other site 518766001886 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 518766001887 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 518766001888 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 518766001889 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 518766001890 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 518766001891 lipoyl attachment site [posttranslational modification]; other site 518766001892 GMP synthase; Reviewed; Region: guaA; PRK00074 518766001893 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 518766001894 AMP/PPi binding site [chemical binding]; other site 518766001895 candidate oxyanion hole; other site 518766001896 catalytic triad [active] 518766001897 potential glutamine specificity residues [chemical binding]; other site 518766001898 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 518766001899 ATP Binding subdomain [chemical binding]; other site 518766001900 Ligand Binding sites [chemical binding]; other site 518766001901 Dimerization subdomain; other site 518766001902 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 518766001903 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 518766001904 ligand binding site [chemical binding]; other site 518766001905 Outer membrane lipoprotein; Region: YfiO; pfam13525 518766001906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766001907 binding surface 518766001908 TPR motif; other site 518766001909 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 518766001910 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 518766001911 active site 518766001912 (T/H)XGH motif; other site 518766001913 Tetratricopeptide repeat; Region: TPR_12; pfam13424 518766001914 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 518766001915 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 518766001916 substrate binding [chemical binding]; other site 518766001917 active site 518766001918 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 518766001919 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 518766001920 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 518766001921 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 518766001922 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 518766001923 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 518766001924 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 518766001925 N-terminal plug; other site 518766001926 ligand-binding site [chemical binding]; other site 518766001927 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 518766001928 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 518766001929 DNA binding residues [nucleotide binding] 518766001930 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 518766001931 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 518766001932 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766001933 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 518766001934 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 518766001935 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766001936 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 518766001937 starch binding outer membrane protein SusD; Region: SusD; cd08977 518766001938 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 518766001939 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 518766001940 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 518766001941 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 518766001942 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 518766001943 N- and C-terminal domain interface [polypeptide binding]; other site 518766001944 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 518766001945 active site 518766001946 putative catalytic site [active] 518766001947 metal binding site [ion binding]; metal-binding site 518766001948 ATP binding site [chemical binding]; other site 518766001949 carbohydrate binding site [chemical binding]; other site 518766001950 short chain dehydrogenase; Validated; Region: PRK08324 518766001951 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 518766001952 active site 518766001953 Zn2+ binding site [ion binding]; other site 518766001954 intersubunit interface [polypeptide binding]; other site 518766001955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 518766001956 NAD(P) binding site [chemical binding]; other site 518766001957 active site 518766001958 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 518766001959 Cysteine-rich domain; Region: CCG; pfam02754 518766001960 Cysteine-rich domain; Region: CCG; pfam02754 518766001961 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 518766001962 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 518766001963 4Fe-4S binding domain; Region: Fer4; pfam00037 518766001964 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 518766001965 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 518766001966 Threonine dehydrogenase; Region: TDH; cd05281 518766001967 structural Zn binding site [ion binding]; other site 518766001968 catalytic Zn binding site [ion binding]; other site 518766001969 tetramer interface [polypeptide binding]; other site 518766001970 NADP binding site [chemical binding]; other site 518766001971 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 518766001972 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 518766001973 substrate-cofactor binding pocket; other site 518766001974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766001975 catalytic residue [active] 518766001976 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 518766001977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766001978 S-adenosylmethionine binding site [chemical binding]; other site 518766001979 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 518766001980 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 518766001981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766001982 Walker A motif; other site 518766001983 ATP binding site [chemical binding]; other site 518766001984 Walker B motif; other site 518766001985 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 518766001986 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 518766001987 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 518766001988 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 518766001989 Surface antigen; Region: Bac_surface_Ag; pfam01103 518766001990 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 518766001991 Family of unknown function (DUF490); Region: DUF490; pfam04357 518766001992 Family of unknown function (DUF490); Region: DUF490; pfam04357 518766001993 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 518766001994 Permease; Region: Permease; pfam02405 518766001995 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 518766001996 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 518766001997 Walker A/P-loop; other site 518766001998 ATP binding site [chemical binding]; other site 518766001999 Q-loop/lid; other site 518766002000 ABC transporter signature motif; other site 518766002001 Walker B; other site 518766002002 D-loop; other site 518766002003 H-loop/switch region; other site 518766002004 mce related protein; Region: MCE; pfam02470 518766002005 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 518766002006 Domain of unknown function DUF20; Region: UPF0118; pfam01594 518766002007 Protein of unknown function (DUF448); Region: DUF448; pfam04296 518766002008 putative RNA binding cleft [nucleotide binding]; other site 518766002009 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 518766002010 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 518766002011 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 518766002012 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 518766002013 Methyltransferase domain; Region: Methyltransf_31; pfam13847 518766002014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766002015 S-adenosylmethionine binding site [chemical binding]; other site 518766002016 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 518766002017 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 518766002018 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 518766002019 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 518766002020 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 518766002021 catalytic residue [active] 518766002022 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 518766002023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 518766002024 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 518766002025 Coenzyme A binding pocket [chemical binding]; other site 518766002026 SurA N-terminal domain; Region: SurA_N_3; cl07813 518766002027 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 518766002028 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 518766002029 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 518766002030 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 518766002031 HIGH motif; other site 518766002032 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 518766002033 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 518766002034 active site 518766002035 KMSKS motif; other site 518766002036 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 518766002037 tRNA binding surface [nucleotide binding]; other site 518766002038 anticodon binding site; other site 518766002039 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 518766002040 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 518766002041 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 518766002042 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 518766002043 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 518766002044 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 518766002045 inhibitor-cofactor binding pocket; inhibition site 518766002046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766002047 catalytic residue [active] 518766002048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766002049 binding surface 518766002050 TPR motif; other site 518766002051 TPR repeat; Region: TPR_11; pfam13414 518766002052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766002053 TPR motif; other site 518766002054 TPR repeat; Region: TPR_11; pfam13414 518766002055 binding surface 518766002056 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 518766002057 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 518766002058 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 518766002059 ligand binding site [chemical binding]; other site 518766002060 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 518766002061 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 518766002062 active site 518766002063 Substrate binding site; other site 518766002064 Mg++ binding site; other site 518766002065 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 518766002066 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 518766002067 MutS domain III; Region: MutS_III; pfam05192 518766002068 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 518766002069 Walker A/P-loop; other site 518766002070 ATP binding site [chemical binding]; other site 518766002071 Q-loop/lid; other site 518766002072 ABC transporter signature motif; other site 518766002073 Walker B; other site 518766002074 D-loop; other site 518766002075 H-loop/switch region; other site 518766002076 Smr domain; Region: Smr; pfam01713 518766002077 glyoxylate reductase; Reviewed; Region: PRK13243 518766002078 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 518766002079 dimerization interface [polypeptide binding]; other site 518766002080 ligand binding site [chemical binding]; other site 518766002081 NADP binding site [chemical binding]; other site 518766002082 catalytic site [active] 518766002083 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 518766002084 dimerization interface [polypeptide binding]; other site 518766002085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 518766002086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766002087 dimer interface [polypeptide binding]; other site 518766002088 phosphorylation site [posttranslational modification] 518766002089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766002090 ATP binding site [chemical binding]; other site 518766002091 Mg2+ binding site [ion binding]; other site 518766002092 G-X-G motif; other site 518766002093 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 518766002094 TrkA-N domain; Region: TrkA_N; pfam02254 518766002095 TrkA-C domain; Region: TrkA_C; pfam02080 518766002096 TrkA-N domain; Region: TrkA_N; pfam02254 518766002097 TrkA-C domain; Region: TrkA_C; pfam02080 518766002098 Cation transport protein; Region: TrkH; cl17365 518766002099 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 518766002100 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 518766002101 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 518766002102 PYR/PP interface [polypeptide binding]; other site 518766002103 dimer interface [polypeptide binding]; other site 518766002104 TPP binding site [chemical binding]; other site 518766002105 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 518766002106 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 518766002107 TPP-binding site [chemical binding]; other site 518766002108 dimer interface [polypeptide binding]; other site 518766002109 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 518766002110 putative valine binding site [chemical binding]; other site 518766002111 dimer interface [polypeptide binding]; other site 518766002112 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 518766002113 ketol-acid reductoisomerase; Provisional; Region: PRK05479 518766002114 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 518766002115 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 518766002116 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 518766002117 tartrate dehydrogenase; Region: TTC; TIGR02089 518766002118 2-isopropylmalate synthase; Validated; Region: PRK00915 518766002119 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 518766002120 active site 518766002121 catalytic residues [active] 518766002122 metal binding site [ion binding]; metal-binding site 518766002123 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 518766002124 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 518766002125 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 518766002126 substrate binding site [chemical binding]; other site 518766002127 ligand binding site [chemical binding]; other site 518766002128 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 518766002129 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 518766002130 substrate binding site [chemical binding]; other site 518766002131 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 518766002132 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 518766002133 active site 518766002134 catalytic residues [active] 518766002135 metal binding site [ion binding]; metal-binding site 518766002136 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 518766002137 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 518766002138 catalytic triad [active] 518766002139 putative active site [active] 518766002140 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 518766002141 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 518766002142 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 518766002143 homodimer interface [polypeptide binding]; other site 518766002144 metal binding site [ion binding]; metal-binding site 518766002145 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 518766002146 homodimer interface [polypeptide binding]; other site 518766002147 active site 518766002148 putative chemical substrate binding site [chemical binding]; other site 518766002149 metal binding site [ion binding]; metal-binding site 518766002150 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 518766002151 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 518766002152 dimer interface [polypeptide binding]; other site 518766002153 ssDNA binding site [nucleotide binding]; other site 518766002154 tetramer (dimer of dimers) interface [polypeptide binding]; other site 518766002155 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 518766002156 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 518766002157 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 518766002158 protein binding site [polypeptide binding]; other site 518766002159 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 518766002160 protein binding site [polypeptide binding]; other site 518766002161 fumarate hydratase; Reviewed; Region: fumC; PRK00485 518766002162 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 518766002163 active sites [active] 518766002164 tetramer interface [polypeptide binding]; other site 518766002165 pantoate--beta-alanine ligase; Region: panC; TIGR00018 518766002166 Pantoate-beta-alanine ligase; Region: PanC; cd00560 518766002167 active site 518766002168 ATP-binding site [chemical binding]; other site 518766002169 pantoate-binding site; other site 518766002170 HXXH motif; other site 518766002171 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 518766002172 tetramerization interface [polypeptide binding]; other site 518766002173 active site 518766002174 KWG Leptospira; Region: KWG; pfam07656 518766002175 KWG Leptospira; Region: KWG; pfam07656 518766002176 KWG Leptospira; Region: KWG; pfam07656 518766002177 KWG Leptospira; Region: KWG; pfam07656 518766002178 KWG Leptospira; Region: KWG; pfam07656 518766002179 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 518766002180 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 518766002181 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 518766002182 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 518766002183 PhoH-like protein; Region: PhoH; pfam02562 518766002184 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 518766002185 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 518766002186 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 518766002187 SurA N-terminal domain; Region: SurA_N_3; cl07813 518766002188 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 518766002189 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 518766002190 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 518766002191 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 518766002192 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766002193 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 518766002194 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 518766002195 DNA binding residues [nucleotide binding] 518766002196 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 518766002197 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 518766002198 AAA domain; Region: AAA_17; pfam13207 518766002199 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 518766002200 FHIPEP family; Region: FHIPEP; pfam00771 518766002201 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 518766002202 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 518766002203 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 518766002204 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 518766002205 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 518766002206 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 518766002207 flagellar motor switch protein FliN; Region: fliN; TIGR02480 518766002208 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 518766002209 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 518766002210 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 518766002211 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 518766002212 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 518766002213 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 518766002214 ligand binding site [chemical binding]; other site 518766002215 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 518766002216 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 518766002217 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 518766002218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766002219 active site 518766002220 phosphorylation site [posttranslational modification] 518766002221 intermolecular recognition site; other site 518766002222 dimerization interface [polypeptide binding]; other site 518766002223 CheB methylesterase; Region: CheB_methylest; pfam01339 518766002224 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 518766002225 putative binding surface; other site 518766002226 active site 518766002227 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 518766002228 putative binding surface; other site 518766002229 active site 518766002230 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 518766002231 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 518766002232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766002233 ATP binding site [chemical binding]; other site 518766002234 Mg2+ binding site [ion binding]; other site 518766002235 G-X-G motif; other site 518766002236 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 518766002237 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 518766002238 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 518766002239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766002240 active site 518766002241 phosphorylation site [posttranslational modification] 518766002242 intermolecular recognition site; other site 518766002243 dimerization interface [polypeptide binding]; other site 518766002244 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 518766002245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766002246 active site 518766002247 phosphorylation site [posttranslational modification] 518766002248 intermolecular recognition site; other site 518766002249 dimerization interface [polypeptide binding]; other site 518766002250 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 518766002251 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 518766002252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766002253 S-adenosylmethionine binding site [chemical binding]; other site 518766002254 HEAT repeats; Region: HEAT_2; pfam13646 518766002255 HEAT repeats; Region: HEAT_2; pfam13646 518766002256 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 518766002257 putative CheA interaction surface; other site 518766002258 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 518766002259 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 518766002260 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 518766002261 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 518766002262 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 518766002263 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 518766002264 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 518766002265 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 518766002266 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 518766002267 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 518766002268 Walker A motif/ATP binding site; other site 518766002269 Walker B motif; other site 518766002270 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 518766002271 FliG C-terminal domain; Region: FliG_C; pfam01706 518766002272 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 518766002273 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 518766002274 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 518766002275 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 518766002276 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 518766002277 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 518766002278 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 518766002279 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 518766002280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 518766002281 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 518766002282 dimer interface [polypeptide binding]; other site 518766002283 phosphorylation site [posttranslational modification] 518766002284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766002285 ATP binding site [chemical binding]; other site 518766002286 Mg2+ binding site [ion binding]; other site 518766002287 G-X-G motif; other site 518766002288 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 518766002289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766002290 active site 518766002291 phosphorylation site [posttranslational modification] 518766002292 intermolecular recognition site; other site 518766002293 dimerization interface [polypeptide binding]; other site 518766002294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766002295 Walker A motif; other site 518766002296 ATP binding site [chemical binding]; other site 518766002297 Walker B motif; other site 518766002298 arginine finger; other site 518766002299 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 518766002300 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 518766002301 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 518766002302 Flagellar protein FliS; Region: FliS; cl00654 518766002303 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 518766002304 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 518766002305 putative metal binding site; other site 518766002306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766002307 binding surface 518766002308 TPR motif; other site 518766002309 flagellin; Provisional; Region: PRK12802 518766002310 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 518766002311 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 518766002312 flagellin; Provisional; Region: PRK12802 518766002313 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 518766002314 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 518766002315 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 518766002316 dimer interface [polypeptide binding]; other site 518766002317 allosteric magnesium binding site [ion binding]; other site 518766002318 active site 518766002319 aspartate-rich active site metal binding site; other site 518766002320 Schiff base residues; other site 518766002321 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 518766002322 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 518766002323 active site 518766002324 HIGH motif; other site 518766002325 nucleotide binding site [chemical binding]; other site 518766002326 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 518766002327 KMSKS motif; other site 518766002328 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 518766002329 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 518766002330 MPT binding site; other site 518766002331 trimer interface [polypeptide binding]; other site 518766002332 Haemolytic domain; Region: Haemolytic; pfam01809 518766002333 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 518766002334 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 518766002335 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 518766002336 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 518766002337 active site 518766002338 metal binding site [ion binding]; metal-binding site 518766002339 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 518766002340 active site 518766002341 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 518766002342 homotrimer interaction site [polypeptide binding]; other site 518766002343 putative active site [active] 518766002344 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 518766002345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 518766002346 NAD(P) binding site [chemical binding]; other site 518766002347 active site 518766002348 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 518766002349 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 518766002350 Ligand Binding Site [chemical binding]; other site 518766002351 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 518766002352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766002353 active site 518766002354 phosphorylation site [posttranslational modification] 518766002355 intermolecular recognition site; other site 518766002356 dimerization interface [polypeptide binding]; other site 518766002357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 518766002358 DNA binding site [nucleotide binding] 518766002359 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 518766002360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766002361 active site 518766002362 phosphorylation site [posttranslational modification] 518766002363 intermolecular recognition site; other site 518766002364 dimerization interface [polypeptide binding]; other site 518766002365 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 518766002366 DNA binding site [nucleotide binding] 518766002367 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 518766002368 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 518766002369 oligomer interface [polypeptide binding]; other site 518766002370 active site 518766002371 metal binding site [ion binding]; metal-binding site 518766002372 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 518766002373 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 518766002374 NAD(P) binding site [chemical binding]; other site 518766002375 catalytic residues [active] 518766002376 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 518766002377 Isochorismatase family; Region: Isochorismatase; pfam00857 518766002378 catalytic triad [active] 518766002379 metal binding site [ion binding]; metal-binding site 518766002380 conserved cis-peptide bond; other site 518766002381 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 518766002382 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 518766002383 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766002384 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 518766002385 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 518766002386 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766002387 putative ADP-binding pocket [chemical binding]; other site 518766002388 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 518766002389 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 518766002390 active site 518766002391 dimer interface [polypeptide binding]; other site 518766002392 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 518766002393 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 518766002394 intersubunit interface [polypeptide binding]; other site 518766002395 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 518766002396 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 518766002397 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 518766002398 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 518766002399 Domain of unknown function DUF21; Region: DUF21; pfam01595 518766002400 Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Region: COG3620 518766002401 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 518766002402 Bacterial Ig-like domain; Region: Big_5; pfam13205 518766002403 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 518766002404 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766002405 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 518766002406 Peptidase family M50; Region: Peptidase_M50; pfam02163 518766002407 active site 518766002408 putative substrate binding region [chemical binding]; other site 518766002409 FOG: CBS domain [General function prediction only]; Region: COG0517 518766002410 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 518766002411 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 518766002412 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 518766002413 domain interfaces; other site 518766002414 active site 518766002415 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 518766002416 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 518766002417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766002418 Walker B motif; other site 518766002419 arginine finger; other site 518766002420 Peptidase family M41; Region: Peptidase_M41; pfam01434 518766002421 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 518766002422 S17 interaction site [polypeptide binding]; other site 518766002423 S8 interaction site; other site 518766002424 16S rRNA interaction site [nucleotide binding]; other site 518766002425 streptomycin interaction site [chemical binding]; other site 518766002426 23S rRNA interaction site [nucleotide binding]; other site 518766002427 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 518766002428 30S ribosomal protein S7; Validated; Region: PRK05302 518766002429 elongation factor G; Reviewed; Region: PRK00007 518766002430 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 518766002431 G1 box; other site 518766002432 putative GEF interaction site [polypeptide binding]; other site 518766002433 GTP/Mg2+ binding site [chemical binding]; other site 518766002434 Switch I region; other site 518766002435 G2 box; other site 518766002436 G3 box; other site 518766002437 Switch II region; other site 518766002438 G4 box; other site 518766002439 G5 box; other site 518766002440 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 518766002441 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 518766002442 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 518766002443 elongation factor Tu; Reviewed; Region: PRK00049 518766002444 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 518766002445 G1 box; other site 518766002446 GEF interaction site [polypeptide binding]; other site 518766002447 GTP/Mg2+ binding site [chemical binding]; other site 518766002448 Switch I region; other site 518766002449 G2 box; other site 518766002450 G3 box; other site 518766002451 Switch II region; other site 518766002452 G4 box; other site 518766002453 G5 box; other site 518766002454 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 518766002455 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 518766002456 Antibiotic Binding Site [chemical binding]; other site 518766002457 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 518766002458 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 518766002459 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 518766002460 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 518766002461 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 518766002462 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 518766002463 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 518766002464 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 518766002465 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 518766002466 putative translocon binding site; other site 518766002467 protein-rRNA interface [nucleotide binding]; other site 518766002468 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 518766002469 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 518766002470 G-X-X-G motif; other site 518766002471 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 518766002472 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 518766002473 23S rRNA interface [nucleotide binding]; other site 518766002474 5S rRNA interface [nucleotide binding]; other site 518766002475 putative antibiotic binding site [chemical binding]; other site 518766002476 L25 interface [polypeptide binding]; other site 518766002477 L27 interface [polypeptide binding]; other site 518766002478 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 518766002479 23S rRNA interface [nucleotide binding]; other site 518766002480 putative translocon interaction site; other site 518766002481 signal recognition particle (SRP54) interaction site; other site 518766002482 L23 interface [polypeptide binding]; other site 518766002483 trigger factor interaction site; other site 518766002484 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 518766002485 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 518766002486 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 518766002487 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 518766002488 RNA binding site [nucleotide binding]; other site 518766002489 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 518766002490 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 518766002491 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 518766002492 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 518766002493 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 518766002494 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 518766002495 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 518766002496 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 518766002497 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 518766002498 5S rRNA interface [nucleotide binding]; other site 518766002499 L27 interface [polypeptide binding]; other site 518766002500 23S rRNA interface [nucleotide binding]; other site 518766002501 L5 interface [polypeptide binding]; other site 518766002502 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 518766002503 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 518766002504 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 518766002505 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 518766002506 23S rRNA binding site [nucleotide binding]; other site 518766002507 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 518766002508 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 518766002509 SecY translocase; Region: SecY; pfam00344 518766002510 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 518766002511 active site 518766002512 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 518766002513 rRNA binding site [nucleotide binding]; other site 518766002514 predicted 30S ribosome binding site; other site 518766002515 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 518766002516 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 518766002517 30S ribosomal protein S13; Region: bact_S13; TIGR03631 518766002518 30S ribosomal protein S11; Validated; Region: PRK05309 518766002519 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 518766002520 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 518766002521 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 518766002522 RNA binding surface [nucleotide binding]; other site 518766002523 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 518766002524 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 518766002525 alphaNTD homodimer interface [polypeptide binding]; other site 518766002526 alphaNTD - beta interaction site [polypeptide binding]; other site 518766002527 alphaNTD - beta' interaction site [polypeptide binding]; other site 518766002528 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 518766002529 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 518766002530 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 518766002531 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 518766002532 Zn2+ binding site [ion binding]; other site 518766002533 Mg2+ binding site [ion binding]; other site 518766002534 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 518766002535 synthetase active site [active] 518766002536 NTP binding site [chemical binding]; other site 518766002537 metal binding site [ion binding]; metal-binding site 518766002538 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 518766002539 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 518766002540 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 518766002541 IHF - DNA interface [nucleotide binding]; other site 518766002542 IHF dimer interface [polypeptide binding]; other site 518766002543 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 518766002544 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 518766002545 active site 518766002546 catalytic residues [active] 518766002547 metal binding site [ion binding]; metal-binding site 518766002548 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766002549 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 518766002550 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 518766002551 N-terminal plug; other site 518766002552 ligand-binding site [chemical binding]; other site 518766002553 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 518766002554 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 518766002555 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 518766002556 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 518766002557 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 518766002558 ligand binding site [chemical binding]; other site 518766002559 MerC mercury resistance protein; Region: MerC; pfam03203 518766002560 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 518766002561 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 518766002562 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 518766002563 HlyD family secretion protein; Region: HlyD_3; pfam13437 518766002564 Outer membrane efflux protein; Region: OEP; pfam02321 518766002565 Outer membrane efflux protein; Region: OEP; pfam02321 518766002566 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 518766002567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 518766002568 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 518766002569 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 518766002570 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 518766002571 Substrate binding site; other site 518766002572 Cupin domain; Region: Cupin_2; cl17218 518766002573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 518766002574 binding surface 518766002575 TPR motif; other site 518766002576 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 518766002577 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 518766002578 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 518766002579 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 518766002580 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 518766002581 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 518766002582 O-Antigen ligase; Region: Wzy_C; pfam04932 518766002583 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766002584 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 518766002585 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 518766002586 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 518766002587 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 518766002588 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 518766002589 Bacterial sugar transferase; Region: Bac_transf; pfam02397 518766002590 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 518766002591 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 518766002592 Peptidase family M1; Region: Peptidase_M1; pfam01433 518766002593 Zn binding site [ion binding]; other site 518766002594 FOG: CBS domain [General function prediction only]; Region: COG0517 518766002595 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 518766002596 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 518766002597 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 518766002598 HlyD family secretion protein; Region: HlyD_3; pfam13437 518766002599 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 518766002600 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 518766002601 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 518766002602 Mechanosensitive ion channel; Region: MS_channel; pfam00924 518766002603 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 518766002604 M28 Zn-Peptidases; Region: M28_like_4; cd08015 518766002605 Peptidase family M28; Region: Peptidase_M28; pfam04389 518766002606 metal binding site [ion binding]; metal-binding site 518766002607 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 518766002608 CrcB-like protein; Region: CRCB; cl09114 518766002609 BNR repeat-like domain; Region: BNR_2; pfam13088 518766002610 BNR repeat-like domain; Region: BNR_2; pfam13088 518766002611 VPS10 domain; Region: VPS10; smart00602 518766002612 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 518766002613 malate dehydrogenase; Reviewed; Region: PRK06223 518766002614 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 518766002615 NAD(P) binding site [chemical binding]; other site 518766002616 dimer interface [polypeptide binding]; other site 518766002617 tetramer (dimer of dimers) interface [polypeptide binding]; other site 518766002618 substrate binding site [chemical binding]; other site 518766002619 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 518766002620 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 518766002621 NAD(P) binding site [chemical binding]; other site 518766002622 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 518766002623 [2Fe-2S] cluster binding site [ion binding]; other site 518766002624 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 518766002625 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 518766002626 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 518766002627 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766002628 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766002629 NusB family; Region: NusB; pfam01029 518766002630 putative RNA binding site [nucleotide binding]; other site 518766002631 16S rRNA methyltransferase B; Provisional; Region: PRK14902 518766002632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766002633 S-adenosylmethionine binding site [chemical binding]; other site 518766002634 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 518766002635 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 518766002636 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 518766002637 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 518766002638 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 518766002639 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 518766002640 substrate binding site [chemical binding]; other site 518766002641 oxyanion hole (OAH) forming residues; other site 518766002642 trimer interface [polypeptide binding]; other site 518766002643 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 518766002644 B12 binding site [chemical binding]; other site 518766002645 cobalt ligand [ion binding]; other site 518766002646 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 518766002647 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 518766002648 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 518766002649 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 518766002650 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 518766002651 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 518766002652 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 518766002653 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 518766002654 Beta-lactamase; Region: Beta-lactamase; pfam00144 518766002655 HerA helicase [Replication, recombination, and repair]; Region: COG0433 518766002656 Domain of unknown function DUF87; Region: DUF87; pfam01935 518766002657 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 518766002658 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 518766002659 FeS/SAM binding site; other site 518766002660 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 518766002661 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 518766002662 homodimer interface [polypeptide binding]; other site 518766002663 substrate-cofactor binding pocket; other site 518766002664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766002665 catalytic residue [active] 518766002666 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 518766002667 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 518766002668 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 518766002669 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 518766002670 nucleotide binding site [chemical binding]; other site 518766002671 substrate binding site [chemical binding]; other site 518766002672 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 518766002673 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 518766002674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 518766002675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 518766002676 Coenzyme A binding pocket [chemical binding]; other site 518766002677 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 518766002678 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766002679 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 518766002680 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 518766002681 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 518766002682 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 518766002683 FeS/SAM binding site; other site 518766002684 HemN C-terminal domain; Region: HemN_C; pfam06969 518766002685 NurA domain; Region: NurA; pfam09376 518766002686 HAS barrel domain; Region: HAS-barrel; pfam09378 518766002687 pyruvate phosphate dikinase; Provisional; Region: PRK09279 518766002688 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 518766002689 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 518766002690 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 518766002691 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 518766002692 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 518766002693 dimerization interface [polypeptide binding]; other site 518766002694 DPS ferroxidase diiron center [ion binding]; other site 518766002695 ion pore; other site 518766002696 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 518766002697 MOFRL family; Region: MOFRL; pfam05161 518766002698 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 518766002699 nucleotide binding site [chemical binding]; other site 518766002700 N-acetyl-L-glutamate binding site [chemical binding]; other site 518766002701 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 518766002702 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 518766002703 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 518766002704 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 518766002705 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 518766002706 inhibitor-cofactor binding pocket; inhibition site 518766002707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766002708 catalytic residue [active] 518766002709 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 518766002710 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 518766002711 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 518766002712 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 518766002713 argininosuccinate synthase; Provisional; Region: PRK13820 518766002714 ANP binding site [chemical binding]; other site 518766002715 Substrate Binding Site II [chemical binding]; other site 518766002716 Substrate Binding Site I [chemical binding]; other site 518766002717 Mechanosensitive ion channel; Region: MS_channel; pfam00924 518766002718 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 518766002719 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 518766002720 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 518766002721 homodimer interface [polypeptide binding]; other site 518766002722 NADP binding site [chemical binding]; other site 518766002723 substrate binding site [chemical binding]; other site 518766002724 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 518766002725 active site 518766002726 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 518766002727 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 518766002728 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 518766002729 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 518766002730 CAAX protease self-immunity; Region: Abi; pfam02517 518766002731 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 518766002732 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 518766002733 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 518766002734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766002735 ATP binding site [chemical binding]; other site 518766002736 Mg2+ binding site [ion binding]; other site 518766002737 G-X-G motif; other site 518766002738 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 518766002739 ATP binding site [chemical binding]; other site 518766002740 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 518766002741 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 518766002742 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 518766002743 TilS substrate C-terminal domain; Region: TilS_C; smart00977 518766002744 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 518766002745 active site 518766002746 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 518766002747 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 518766002748 active site 518766002749 dimer interface [polypeptide binding]; other site 518766002750 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 518766002751 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 518766002752 Ligand Binding Site [chemical binding]; other site 518766002753 Molecular Tunnel; other site 518766002754 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 518766002755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 518766002756 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 518766002757 Walker A/P-loop; other site 518766002758 ATP binding site [chemical binding]; other site 518766002759 Q-loop/lid; other site 518766002760 ABC transporter signature motif; other site 518766002761 Walker B; other site 518766002762 D-loop; other site 518766002763 H-loop/switch region; other site 518766002764 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 518766002765 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 518766002766 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 518766002767 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 518766002768 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 518766002769 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 518766002770 DNA primase; Validated; Region: dnaG; PRK05667 518766002771 CHC2 zinc finger; Region: zf-CHC2; pfam01807 518766002772 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 518766002773 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 518766002774 active site 518766002775 metal binding site [ion binding]; metal-binding site 518766002776 interdomain interaction site; other site 518766002777 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 518766002778 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766002779 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766002780 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 518766002781 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 518766002782 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 518766002783 active site 518766002784 homotetramer interface [polypeptide binding]; other site 518766002785 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 518766002786 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 518766002787 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 518766002788 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 518766002789 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 518766002790 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 518766002791 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 518766002792 active site residue [active] 518766002793 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 518766002794 active site residue [active] 518766002795 Fe-S metabolism associated domain; Region: SufE; cl00951 518766002796 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 518766002797 putative active site [active] 518766002798 putative CoA binding site [chemical binding]; other site 518766002799 nudix motif; other site 518766002800 metal binding site [ion binding]; metal-binding site 518766002801 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 518766002802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766002803 active site 518766002804 phosphorylation site [posttranslational modification] 518766002805 intermolecular recognition site; other site 518766002806 dimerization interface [polypeptide binding]; other site 518766002807 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 518766002808 DNA binding site [nucleotide binding] 518766002809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 518766002810 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 518766002811 dimerization interface [polypeptide binding]; other site 518766002812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766002813 dimer interface [polypeptide binding]; other site 518766002814 phosphorylation site [posttranslational modification] 518766002815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766002816 ATP binding site [chemical binding]; other site 518766002817 G-X-G motif; other site 518766002818 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 518766002819 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 518766002820 putative dimer interface [polypeptide binding]; other site 518766002821 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 518766002822 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766002823 TPR motif; other site 518766002824 binding surface 518766002825 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766002826 binding surface 518766002827 TPR motif; other site 518766002828 TPR repeat; Region: TPR_11; pfam13414 518766002829 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 518766002830 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 518766002831 tetramer interface [polypeptide binding]; other site 518766002832 TPP-binding site [chemical binding]; other site 518766002833 heterodimer interface [polypeptide binding]; other site 518766002834 phosphorylation loop region [posttranslational modification] 518766002835 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 518766002836 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 518766002837 alpha subunit interface [polypeptide binding]; other site 518766002838 TPP binding site [chemical binding]; other site 518766002839 heterodimer interface [polypeptide binding]; other site 518766002840 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 518766002841 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 518766002842 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 518766002843 dimerization interface [polypeptide binding]; other site 518766002844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766002845 dimer interface [polypeptide binding]; other site 518766002846 phosphorylation site [posttranslational modification] 518766002847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766002848 ATP binding site [chemical binding]; other site 518766002849 Mg2+ binding site [ion binding]; other site 518766002850 G-X-G motif; other site 518766002851 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 518766002852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766002853 active site 518766002854 phosphorylation site [posttranslational modification] 518766002855 intermolecular recognition site; other site 518766002856 dimerization interface [polypeptide binding]; other site 518766002857 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 518766002858 DNA binding site [nucleotide binding] 518766002859 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 518766002860 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 518766002861 active site 518766002862 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 518766002863 dimer interface [polypeptide binding]; other site 518766002864 substrate binding site [chemical binding]; other site 518766002865 catalytic residues [active] 518766002866 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 518766002867 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 518766002868 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 518766002869 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 518766002870 dihydroorotase; Validated; Region: pyrC; PRK09357 518766002871 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 518766002872 active site 518766002873 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 518766002874 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 518766002875 ATP-grasp domain; Region: ATP-grasp_4; cl17255 518766002876 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 518766002877 4-alpha-glucanotransferase; Provisional; Region: PRK14508 518766002878 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766002879 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 518766002880 Interdomain contacts; other site 518766002881 Cytokine receptor motif; other site 518766002882 von Willebrand factor type D domain; Region: VWD; pfam00094 518766002883 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 518766002884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766002885 active site 518766002886 phosphorylation site [posttranslational modification] 518766002887 intermolecular recognition site; other site 518766002888 dimerization interface [polypeptide binding]; other site 518766002889 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 518766002890 DNA binding residues [nucleotide binding] 518766002891 dimerization interface [polypeptide binding]; other site 518766002892 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 518766002893 Two component regulator propeller; Region: Reg_prop; pfam07494 518766002894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 518766002895 Histidine kinase; Region: HisKA_3; pfam07730 518766002896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766002897 ATP binding site [chemical binding]; other site 518766002898 Mg2+ binding site [ion binding]; other site 518766002899 G-X-G motif; other site 518766002900 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 518766002901 Ligand Binding Site [chemical binding]; other site 518766002902 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 518766002903 Ligand Binding Site [chemical binding]; other site 518766002904 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 518766002905 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 518766002906 Ligand Binding Site [chemical binding]; other site 518766002907 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 518766002908 Ligand Binding Site [chemical binding]; other site 518766002909 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 518766002910 polyphosphate kinase; Provisional; Region: PRK05443 518766002911 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 518766002912 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 518766002913 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 518766002914 putative domain interface [polypeptide binding]; other site 518766002915 putative active site [active] 518766002916 catalytic site [active] 518766002917 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 518766002918 putative domain interface [polypeptide binding]; other site 518766002919 putative active site [active] 518766002920 catalytic site [active] 518766002921 PAS domain S-box; Region: sensory_box; TIGR00229 518766002922 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766002923 putative active site [active] 518766002924 heme pocket [chemical binding]; other site 518766002925 PAS domain S-box; Region: sensory_box; TIGR00229 518766002926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766002927 putative active site [active] 518766002928 heme pocket [chemical binding]; other site 518766002929 PAS domain S-box; Region: sensory_box; TIGR00229 518766002930 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766002931 putative active site [active] 518766002932 heme pocket [chemical binding]; other site 518766002933 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766002934 PAS domain; Region: PAS_9; pfam13426 518766002935 putative active site [active] 518766002936 heme pocket [chemical binding]; other site 518766002937 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 518766002938 GAF domain; Region: GAF; pfam01590 518766002939 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 518766002940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766002941 putative active site [active] 518766002942 heme pocket [chemical binding]; other site 518766002943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766002944 dimer interface [polypeptide binding]; other site 518766002945 phosphorylation site [posttranslational modification] 518766002946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766002947 ATP binding site [chemical binding]; other site 518766002948 Mg2+ binding site [ion binding]; other site 518766002949 G-X-G motif; other site 518766002950 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 518766002951 active site 518766002952 Int/Topo IB signature motif; other site 518766002953 DNA binding site [nucleotide binding] 518766002954 Helix-turn-helix domain; Region: HTH_17; pfam12728 518766002955 Phage terminase, small subunit; Region: Terminase_4; cl01525 518766002956 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 518766002957 Phage capsid family; Region: Phage_capsid; pfam05065 518766002958 PspC domain; Region: PspC; pfam04024 518766002959 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 518766002960 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 518766002961 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 518766002962 signal recognition particle protein; Provisional; Region: PRK10867 518766002963 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 518766002964 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 518766002965 P loop; other site 518766002966 GTP binding site [chemical binding]; other site 518766002967 Signal peptide binding domain; Region: SRP_SPB; pfam02978 518766002968 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 518766002969 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 518766002970 RimM N-terminal domain; Region: RimM; pfam01782 518766002971 PRC-barrel domain; Region: PRC; pfam05239 518766002972 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 518766002973 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 518766002974 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 518766002975 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 518766002976 SmpB-tmRNA interface; other site 518766002977 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 518766002978 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 518766002979 active site 518766002980 HIGH motif; other site 518766002981 dimer interface [polypeptide binding]; other site 518766002982 KMSKS motif; other site 518766002983 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 518766002984 RNA binding surface [nucleotide binding]; other site 518766002985 AIR carboxylase; Region: AIRC; pfam00731 518766002986 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 518766002987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 518766002988 ATP-grasp domain; Region: ATP-grasp; pfam02222 518766002989 hypothetical protein; Provisional; Region: PRK08262 518766002990 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 518766002991 metal binding site [ion binding]; metal-binding site 518766002992 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 518766002993 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 518766002994 catalytic residues [active] 518766002995 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766002996 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766002997 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766002998 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 518766002999 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 518766003000 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 518766003001 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 518766003002 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 518766003003 active site 518766003004 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 518766003005 HIGH motif; other site 518766003006 dimer interface [polypeptide binding]; other site 518766003007 KMSKS motif; other site 518766003008 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 518766003009 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 518766003010 glutamine binding [chemical binding]; other site 518766003011 catalytic triad [active] 518766003012 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 518766003013 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 518766003014 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 518766003015 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 518766003016 active site 518766003017 ribulose/triose binding site [chemical binding]; other site 518766003018 phosphate binding site [ion binding]; other site 518766003019 substrate (anthranilate) binding pocket [chemical binding]; other site 518766003020 product (indole) binding pocket [chemical binding]; other site 518766003021 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 518766003022 active site 518766003023 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 518766003024 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 518766003025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766003026 catalytic residue [active] 518766003027 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 518766003028 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 518766003029 substrate binding site [chemical binding]; other site 518766003030 active site 518766003031 catalytic residues [active] 518766003032 heterodimer interface [polypeptide binding]; other site 518766003033 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 518766003034 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 518766003035 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 518766003036 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 518766003037 ABC transporter; Region: ABC_tran; pfam00005 518766003038 Q-loop/lid; other site 518766003039 ABC transporter signature motif; other site 518766003040 Walker B; other site 518766003041 D-loop; other site 518766003042 H-loop/switch region; other site 518766003043 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 518766003044 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 518766003045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 518766003046 ATP binding site [chemical binding]; other site 518766003047 putative Mg++ binding site [ion binding]; other site 518766003048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 518766003049 nucleotide binding region [chemical binding]; other site 518766003050 ATP-binding site [chemical binding]; other site 518766003051 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 518766003052 intersubunit interface [polypeptide binding]; other site 518766003053 active site 518766003054 catalytic residue [active] 518766003055 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 518766003056 Mechanosensitive ion channel; Region: MS_channel; pfam00924 518766003057 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 518766003058 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 518766003059 Cl- selectivity filter; other site 518766003060 Cl- binding residues [ion binding]; other site 518766003061 pore gating glutamate residue; other site 518766003062 dimer interface [polypeptide binding]; other site 518766003063 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 518766003064 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 518766003065 substrate binding site [chemical binding]; other site 518766003066 putative active site [active] 518766003067 redox center [active] 518766003068 Thioredoxin; Region: Thioredoxin_4; pfam13462 518766003069 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 518766003070 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 518766003071 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 518766003072 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 518766003073 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 518766003074 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 518766003075 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 518766003076 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 518766003077 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 518766003078 Peptidase family M28; Region: Peptidase_M28; pfam04389 518766003079 putative metal binding site [ion binding]; other site 518766003080 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 518766003081 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 518766003082 Amidase; Region: Amidase; pfam01425 518766003083 Transcriptional regulators [Transcription]; Region: PurR; COG1609 518766003084 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 518766003085 DNA binding site [nucleotide binding] 518766003086 domain linker motif; other site 518766003087 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 518766003088 ligand binding site [chemical binding]; other site 518766003089 dimerization interface [polypeptide binding]; other site 518766003090 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 518766003091 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 518766003092 active site 518766003093 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 518766003094 ligand binding site [chemical binding]; other site 518766003095 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766003096 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 518766003097 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 518766003098 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 518766003099 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766003100 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766003101 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 518766003102 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766003103 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766003104 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 518766003105 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 518766003106 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 518766003107 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 518766003108 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 518766003109 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766003110 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 518766003111 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 518766003112 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766003113 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 518766003114 DNA binding residues [nucleotide binding] 518766003115 FecR protein; Region: FecR; pfam04773 518766003116 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 518766003117 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766003118 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 518766003119 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766003120 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 518766003121 starch binding outer membrane protein SusD; Region: SusD; cd08977 518766003122 SusD family; Region: SusD; pfam07980 518766003123 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 518766003124 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 518766003125 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 518766003126 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 518766003127 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 518766003128 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 518766003129 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 518766003130 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 518766003131 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 518766003132 hypothetical protein; Provisional; Region: PRK04164 518766003133 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 518766003134 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 518766003135 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 518766003136 cobalamin binding residues [chemical binding]; other site 518766003137 putative BtuC binding residues; other site 518766003138 dimer interface [polypeptide binding]; other site 518766003139 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 518766003140 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 518766003141 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 518766003142 N-terminal plug; other site 518766003143 ligand-binding site [chemical binding]; other site 518766003144 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 518766003145 HsdM N-terminal domain; Region: HsdM_N; pfam12161 518766003146 Methyltransferase domain; Region: Methyltransf_26; pfam13659 518766003147 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 518766003148 Divergent AAA domain; Region: AAA_4; pfam04326 518766003149 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 518766003150 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 518766003151 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 518766003152 Transposase IS200 like; Region: Y1_Tnp; cl00848 518766003153 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 518766003154 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 518766003155 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 518766003156 ATP binding site [chemical binding]; other site 518766003157 putative Mg++ binding site [ion binding]; other site 518766003158 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 518766003159 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766003160 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 518766003161 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 518766003162 N-terminal plug; other site 518766003163 ligand-binding site [chemical binding]; other site 518766003164 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 518766003165 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 518766003166 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 518766003167 substrate binding site; other site 518766003168 dimer interface; other site 518766003169 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 518766003170 homotrimer interaction site [polypeptide binding]; other site 518766003171 zinc binding site [ion binding]; other site 518766003172 CDP-binding sites; other site 518766003173 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 518766003174 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 518766003175 elongation factor Tu; Reviewed; Region: PRK00049 518766003176 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 518766003177 G1 box; other site 518766003178 GEF interaction site [polypeptide binding]; other site 518766003179 GTP/Mg2+ binding site [chemical binding]; other site 518766003180 Switch I region; other site 518766003181 G2 box; other site 518766003182 G3 box; other site 518766003183 Switch II region; other site 518766003184 G4 box; other site 518766003185 G5 box; other site 518766003186 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 518766003187 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 518766003188 Antibiotic Binding Site [chemical binding]; other site 518766003189 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 518766003190 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 518766003191 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 518766003192 putative homodimer interface [polypeptide binding]; other site 518766003193 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 518766003194 heterodimer interface [polypeptide binding]; other site 518766003195 homodimer interface [polypeptide binding]; other site 518766003196 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 518766003197 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 518766003198 23S rRNA interface [nucleotide binding]; other site 518766003199 L7/L12 interface [polypeptide binding]; other site 518766003200 putative thiostrepton binding site; other site 518766003201 L25 interface [polypeptide binding]; other site 518766003202 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 518766003203 mRNA/rRNA interface [nucleotide binding]; other site 518766003204 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 518766003205 23S rRNA interface [nucleotide binding]; other site 518766003206 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 518766003207 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 518766003208 core dimer interface [polypeptide binding]; other site 518766003209 peripheral dimer interface [polypeptide binding]; other site 518766003210 L10 interface [polypeptide binding]; other site 518766003211 L11 interface [polypeptide binding]; other site 518766003212 putative EF-Tu interaction site [polypeptide binding]; other site 518766003213 putative EF-G interaction site [polypeptide binding]; other site 518766003214 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 518766003215 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 518766003216 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 518766003217 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 518766003218 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 518766003219 RPB12 interaction site [polypeptide binding]; other site 518766003220 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 518766003221 RPB11 interaction site [polypeptide binding]; other site 518766003222 RPB12 interaction site [polypeptide binding]; other site 518766003223 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 518766003224 RPB3 interaction site [polypeptide binding]; other site 518766003225 RPB1 interaction site [polypeptide binding]; other site 518766003226 RPB11 interaction site [polypeptide binding]; other site 518766003227 RPB10 interaction site [polypeptide binding]; other site 518766003228 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 518766003229 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 518766003230 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 518766003231 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 518766003232 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 518766003233 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 518766003234 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 518766003235 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 518766003236 DNA binding site [nucleotide binding] 518766003237 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 518766003238 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 518766003239 putative active site [active] 518766003240 Zn binding site [ion binding]; other site 518766003241 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 518766003242 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 518766003243 catalytic residues [active] 518766003244 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 518766003245 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 518766003246 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 518766003247 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 518766003248 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 518766003249 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 518766003250 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 518766003251 tetramer interface [polypeptide binding]; other site 518766003252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766003253 catalytic residue [active] 518766003254 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 518766003255 Transglycosylase; Region: Transgly; cl17702 518766003256 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 518766003257 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 518766003258 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 518766003259 NlpC/P60 family; Region: NLPC_P60; pfam00877 518766003260 YtxH-like protein; Region: YtxH; pfam12732 518766003261 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 518766003262 PAS domain S-box; Region: sensory_box; TIGR00229 518766003263 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766003264 putative active site [active] 518766003265 heme pocket [chemical binding]; other site 518766003266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 518766003267 Histidine kinase; Region: HisKA_3; pfam07730 518766003268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766003269 ATP binding site [chemical binding]; other site 518766003270 Mg2+ binding site [ion binding]; other site 518766003271 G-X-G motif; other site 518766003272 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 518766003273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766003274 active site 518766003275 phosphorylation site [posttranslational modification] 518766003276 intermolecular recognition site; other site 518766003277 dimerization interface [polypeptide binding]; other site 518766003278 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 518766003279 DNA binding residues [nucleotide binding] 518766003280 dimerization interface [polypeptide binding]; other site 518766003281 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 518766003282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766003283 active site 518766003284 phosphorylation site [posttranslational modification] 518766003285 intermolecular recognition site; other site 518766003286 dimerization interface [polypeptide binding]; other site 518766003287 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 518766003288 DNA binding residues [nucleotide binding] 518766003289 dimerization interface [polypeptide binding]; other site 518766003290 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 518766003291 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766003292 putative ADP-binding pocket [chemical binding]; other site 518766003293 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 518766003294 Bacterial sugar transferase; Region: Bac_transf; pfam02397 518766003295 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 518766003296 Chain length determinant protein; Region: Wzz; pfam02706 518766003297 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 518766003298 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 518766003299 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 518766003300 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 518766003301 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 518766003302 Walker A/P-loop; other site 518766003303 ATP binding site [chemical binding]; other site 518766003304 Q-loop/lid; other site 518766003305 ABC transporter signature motif; other site 518766003306 Walker B; other site 518766003307 D-loop; other site 518766003308 H-loop/switch region; other site 518766003309 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 518766003310 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 518766003311 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766003312 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 518766003313 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 518766003314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 518766003315 NAD(P) binding site [chemical binding]; other site 518766003316 active site 518766003317 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 518766003318 active site 518766003319 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 518766003320 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 518766003321 NAD binding site [chemical binding]; other site 518766003322 homotetramer interface [polypeptide binding]; other site 518766003323 homodimer interface [polypeptide binding]; other site 518766003324 active site 518766003325 substrate binding site [chemical binding]; other site 518766003326 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766003327 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 518766003328 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766003329 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 518766003330 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 518766003331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766003332 Transposase IS200 like; Region: Y1_Tnp; cl00848 518766003333 Exostosin family; Region: Exostosin; pfam03016 518766003334 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766003335 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 518766003336 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 518766003337 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766003338 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 518766003339 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 518766003340 active site 518766003341 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 518766003342 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766003343 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 518766003344 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766003345 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 518766003346 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766003347 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766003348 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 518766003349 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 518766003350 active site 518766003351 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 518766003352 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 518766003353 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 518766003354 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 518766003355 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 518766003356 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 518766003357 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 518766003358 putative catalytic site [active] 518766003359 putative metal binding site [ion binding]; other site 518766003360 putative phosphate binding site [ion binding]; other site 518766003361 Transcriptional regulators [Transcription]; Region: FadR; COG2186 518766003362 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 518766003363 DNA-binding site [nucleotide binding]; DNA binding site 518766003364 FCD domain; Region: FCD; pfam07729 518766003365 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766003366 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 518766003367 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 518766003368 active site 518766003369 intersubunit interface [polypeptide binding]; other site 518766003370 catalytic residue [active] 518766003371 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 518766003372 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 518766003373 substrate binding site [chemical binding]; other site 518766003374 ATP binding site [chemical binding]; other site 518766003375 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766003376 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 518766003377 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 518766003378 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766003379 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766003380 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 518766003381 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 518766003382 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 518766003383 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 518766003384 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 518766003385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 518766003386 NAD(P) binding site [chemical binding]; other site 518766003387 active site 518766003388 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 518766003389 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 518766003390 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 518766003391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 518766003392 D-galactonate transporter; Region: 2A0114; TIGR00893 518766003393 putative substrate translocation pore; other site 518766003394 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 518766003395 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 518766003396 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 518766003397 Cu(I) binding site [ion binding]; other site 518766003398 Response regulator receiver domain; Region: Response_reg; pfam00072 518766003399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766003400 active site 518766003401 phosphorylation site [posttranslational modification] 518766003402 intermolecular recognition site; other site 518766003403 dimerization interface [polypeptide binding]; other site 518766003404 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 518766003405 methionine gamma-lyase; Validated; Region: PRK07049 518766003406 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 518766003407 homodimer interface [polypeptide binding]; other site 518766003408 substrate-cofactor binding pocket; other site 518766003409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766003410 catalytic residue [active] 518766003411 Peptidase S46; Region: Peptidase_S46; pfam10459 518766003412 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 518766003413 Peptidase S46; Region: Peptidase_S46; pfam10459 518766003414 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 518766003415 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 518766003416 DNA protecting protein DprA; Region: dprA; TIGR00732 518766003417 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 518766003418 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 518766003419 active site 518766003420 nucleophile elbow; other site 518766003421 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 518766003422 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766003423 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 518766003424 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 518766003425 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 518766003426 PGAP1-like protein; Region: PGAP1; pfam07819 518766003427 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 518766003428 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 518766003429 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 518766003430 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 518766003431 substrate binding site [chemical binding]; other site 518766003432 active site 518766003433 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 518766003434 active site 518766003435 NTP binding site [chemical binding]; other site 518766003436 metal binding triad [ion binding]; metal-binding site 518766003437 antibiotic binding site [chemical binding]; other site 518766003438 Probable transposase; Region: OrfB_IS605; pfam01385 518766003439 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 518766003440 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 518766003441 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 518766003442 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 518766003443 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 518766003444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766003445 dimer interface [polypeptide binding]; other site 518766003446 phosphorylation site [posttranslational modification] 518766003447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766003448 ATP binding site [chemical binding]; other site 518766003449 Mg2+ binding site [ion binding]; other site 518766003450 G-X-G motif; other site 518766003451 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 518766003452 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 518766003453 active site 518766003454 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 518766003455 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 518766003456 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 518766003457 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 518766003458 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 518766003459 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 518766003460 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 518766003461 active site 518766003462 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 518766003463 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 518766003464 active site 518766003465 substrate-binding site [chemical binding]; other site 518766003466 metal-binding site [ion binding] 518766003467 ATP binding site [chemical binding]; other site 518766003468 Ferrochelatase; Region: Ferrochelatase; pfam00762 518766003469 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 518766003470 C-terminal domain interface [polypeptide binding]; other site 518766003471 active site 518766003472 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 518766003473 active site 518766003474 N-terminal domain interface [polypeptide binding]; other site 518766003475 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 518766003476 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 518766003477 inhibitor-cofactor binding pocket; inhibition site 518766003478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766003479 catalytic residue [active] 518766003480 ribonuclease R; Region: RNase_R; TIGR02063 518766003481 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 518766003482 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 518766003483 RNB domain; Region: RNB; pfam00773 518766003484 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 518766003485 RNA binding site [nucleotide binding]; other site 518766003486 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 518766003487 Family of unknown function (DUF490); Region: DUF490; pfam04357 518766003488 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 518766003489 active site 518766003490 dimer interface [polypeptide binding]; other site 518766003491 metal binding site [ion binding]; metal-binding site 518766003492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 518766003493 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 518766003494 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766003495 NRDE protein; Region: NRDE; pfam05742 518766003496 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 518766003497 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 518766003498 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 518766003499 catalytic core [active] 518766003500 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 518766003501 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 518766003502 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 518766003503 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 518766003504 putative active site [active] 518766003505 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 518766003506 putative active site [active] 518766003507 Protein of unknown function DUF72; Region: DUF72; pfam01904 518766003508 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 518766003509 DNA-binding site [nucleotide binding]; DNA binding site 518766003510 RNA-binding motif; other site 518766003511 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 518766003512 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 518766003513 hinge; other site 518766003514 active site 518766003515 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 518766003516 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 518766003517 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 518766003518 catalytic residue [active] 518766003519 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 518766003520 AMP binding site [chemical binding]; other site 518766003521 metal binding site [ion binding]; metal-binding site 518766003522 active site 518766003523 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 518766003524 glucose/galactose transporter; Region: gluP; TIGR01272 518766003525 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 518766003526 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 518766003527 active site 518766003528 trimer interface [polypeptide binding]; other site 518766003529 allosteric site; other site 518766003530 active site lid [active] 518766003531 hexamer (dimer of trimers) interface [polypeptide binding]; other site 518766003532 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 518766003533 Helix-turn-helix domain; Region: HTH_25; pfam13413 518766003534 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 518766003535 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 518766003536 nucleotide binding pocket [chemical binding]; other site 518766003537 K-X-D-G motif; other site 518766003538 catalytic site [active] 518766003539 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 518766003540 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 518766003541 Helix-hairpin-helix motif; Region: HHH; pfam00633 518766003542 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 518766003543 Dimer interface [polypeptide binding]; other site 518766003544 BRCT sequence motif; other site 518766003545 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 518766003546 Na binding site [ion binding]; other site 518766003547 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 518766003548 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 518766003549 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 518766003550 Zn2+ binding site [ion binding]; other site 518766003551 Mg2+ binding site [ion binding]; other site 518766003552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 518766003553 DNA-binding site [nucleotide binding]; DNA binding site 518766003554 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 518766003555 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 518766003556 Glutamate binding site [chemical binding]; other site 518766003557 NAD binding site [chemical binding]; other site 518766003558 catalytic residues [active] 518766003559 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 518766003560 adenylate kinase; Reviewed; Region: adk; PRK00279 518766003561 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 518766003562 AMP-binding site [chemical binding]; other site 518766003563 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 518766003564 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 518766003565 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 518766003566 substrate binding pocket [chemical binding]; other site 518766003567 chain length determination region; other site 518766003568 substrate-Mg2+ binding site; other site 518766003569 catalytic residues [active] 518766003570 aspartate-rich region 1; other site 518766003571 active site lid residues [active] 518766003572 aspartate-rich region 2; other site 518766003573 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 518766003574 dimerization domain swap beta strand [polypeptide binding]; other site 518766003575 regulatory protein interface [polypeptide binding]; other site 518766003576 active site 518766003577 regulatory phosphorylation site [posttranslational modification]; other site 518766003578 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 518766003579 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 518766003580 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 518766003581 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 518766003582 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 518766003583 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 518766003584 dimer interface [polypeptide binding]; other site 518766003585 active site 518766003586 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 518766003587 dimer interface [polypeptide binding]; other site 518766003588 active site 518766003589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 518766003590 active site 518766003591 motif I; other site 518766003592 motif II; other site 518766003593 membrane glycoprotein; Provisional; Region: PHA03332 518766003594 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 518766003595 dimer interface [polypeptide binding]; other site 518766003596 Alkaline phosphatase homologues; Region: alkPPc; smart00098 518766003597 active site 518766003598 hypothetical protein; Validated; Region: PRK07883 518766003599 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 518766003600 active site 518766003601 catalytic site [active] 518766003602 substrate binding site [chemical binding]; other site 518766003603 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 518766003604 GIY-YIG motif/motif A; other site 518766003605 active site 518766003606 catalytic site [active] 518766003607 putative DNA binding site [nucleotide binding]; other site 518766003608 metal binding site [ion binding]; metal-binding site 518766003609 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 518766003610 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 518766003611 HD domain; Region: HD; pfam01966 518766003612 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 518766003613 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 518766003614 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 518766003615 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 518766003616 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 518766003617 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 518766003618 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 518766003619 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 518766003620 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 518766003621 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 518766003622 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 518766003623 transmembrane helices; other site 518766003624 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 518766003625 aromatic arch; other site 518766003626 DCoH dimer interaction site [polypeptide binding]; other site 518766003627 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 518766003628 DCoH tetramer interaction site [polypeptide binding]; other site 518766003629 substrate binding site [chemical binding]; other site 518766003630 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 518766003631 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 518766003632 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 518766003633 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 518766003634 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 518766003635 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 518766003636 GIY-YIG motif/motif A; other site 518766003637 active site 518766003638 catalytic site [active] 518766003639 putative DNA binding site [nucleotide binding]; other site 518766003640 metal binding site [ion binding]; metal-binding site 518766003641 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 518766003642 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 518766003643 DNA binding site [nucleotide binding] 518766003644 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 518766003645 putative active site [active] 518766003646 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 518766003647 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 518766003648 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 518766003649 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 518766003650 Walker A/P-loop; other site 518766003651 ATP binding site [chemical binding]; other site 518766003652 Q-loop/lid; other site 518766003653 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 518766003654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 518766003655 ABC transporter signature motif; other site 518766003656 Walker B; other site 518766003657 D-loop; other site 518766003658 H-loop/switch region; other site 518766003659 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 518766003660 EamA-like transporter family; Region: EamA; pfam00892 518766003661 EamA-like transporter family; Region: EamA; pfam00892 518766003662 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 518766003663 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 518766003664 DNA binding residues [nucleotide binding] 518766003665 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 518766003666 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 518766003667 active site 518766003668 dimer interface [polypeptide binding]; other site 518766003669 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 518766003670 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 518766003671 active site 518766003672 FMN binding site [chemical binding]; other site 518766003673 substrate binding site [chemical binding]; other site 518766003674 3Fe-4S cluster binding site [ion binding]; other site 518766003675 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 518766003676 domain interface; other site 518766003677 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 518766003678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 518766003679 homoserine kinase; Provisional; Region: PRK01212 518766003680 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 518766003681 threonine synthase; Validated; Region: PRK09225 518766003682 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 518766003683 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 518766003684 catalytic residue [active] 518766003685 enoyl-CoA hydratase; Provisional; Region: PRK05995 518766003686 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 518766003687 substrate binding site [chemical binding]; other site 518766003688 oxyanion hole (OAH) forming residues; other site 518766003689 trimer interface [polypeptide binding]; other site 518766003690 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 518766003691 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 518766003692 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 518766003693 dimerization interface [polypeptide binding]; other site 518766003694 putative ATP binding site [chemical binding]; other site 518766003695 membrane protein; Provisional; Region: PRK14410 518766003696 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 518766003697 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 518766003698 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 518766003699 Divergent AAA domain; Region: AAA_4; pfam04326 518766003700 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 518766003701 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 518766003702 CAP-like domain; other site 518766003703 active site 518766003704 primary dimer interface [polypeptide binding]; other site 518766003705 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 518766003706 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 518766003707 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 518766003708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766003709 ATP binding site [chemical binding]; other site 518766003710 Mg2+ binding site [ion binding]; other site 518766003711 G-X-G motif; other site 518766003712 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 518766003713 anchoring element; other site 518766003714 dimer interface [polypeptide binding]; other site 518766003715 ATP binding site [chemical binding]; other site 518766003716 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 518766003717 active site 518766003718 putative metal-binding site [ion binding]; other site 518766003719 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 518766003720 EamA-like transporter family; Region: EamA; pfam00892 518766003721 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 518766003722 EamA-like transporter family; Region: EamA; pfam00892 518766003723 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 518766003724 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 518766003725 ABC-ATPase subunit interface; other site 518766003726 dimer interface [polypeptide binding]; other site 518766003727 putative PBP binding regions; other site 518766003728 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 518766003729 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 518766003730 ABC-ATPase subunit interface; other site 518766003731 dimer interface [polypeptide binding]; other site 518766003732 putative PBP binding regions; other site 518766003733 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 518766003734 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 518766003735 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 518766003736 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 518766003737 intersubunit interface [polypeptide binding]; other site 518766003738 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 518766003739 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 518766003740 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 518766003741 FeoA domain; Region: FeoA; pfam04023 518766003742 CHRD domain; Region: CHRD; pfam07452 518766003743 CHRD domain; Region: CHRD; pfam07452 518766003744 CHRD domain; Region: CHRD; pfam07452 518766003745 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766003746 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 518766003747 catalytic residues [active] 518766003748 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 518766003749 FMN reductase; Validated; Region: fre; PRK08051 518766003750 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 518766003751 FAD binding pocket [chemical binding]; other site 518766003752 FAD binding motif [chemical binding]; other site 518766003753 phosphate binding motif [ion binding]; other site 518766003754 beta-alpha-beta structure motif; other site 518766003755 NAD binding pocket [chemical binding]; other site 518766003756 MoxR-like ATPases [General function prediction only]; Region: COG0714 518766003757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766003758 Walker A motif; other site 518766003759 ATP binding site [chemical binding]; other site 518766003760 Walker B motif; other site 518766003761 arginine finger; other site 518766003762 SurA N-terminal domain; Region: SurA_N; pfam09312 518766003763 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 518766003764 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 518766003765 SurA N-terminal domain; Region: SurA_N_3; cl07813 518766003766 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 518766003767 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 518766003768 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 518766003769 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 518766003770 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 518766003771 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 518766003772 HIGH motif; other site 518766003773 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 518766003774 active site 518766003775 KMSKS motif; other site 518766003776 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 518766003777 cytidylate kinase; Provisional; Region: cmk; PRK00023 518766003778 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 518766003779 CMP-binding site; other site 518766003780 The sites determining sugar specificity; other site 518766003781 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 518766003782 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 518766003783 RNA binding site [nucleotide binding]; other site 518766003784 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 518766003785 RNA binding site [nucleotide binding]; other site 518766003786 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 518766003787 RNA binding site [nucleotide binding]; other site 518766003788 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 518766003789 RNA binding site [nucleotide binding]; other site 518766003790 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 518766003791 RNA binding site [nucleotide binding]; other site 518766003792 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 518766003793 RNA binding site [nucleotide binding]; other site 518766003794 HD supefamily hydrolase [General function prediction only]; Region: COG3294 518766003795 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 518766003796 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 518766003797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766003798 catalytic residue [active] 518766003799 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 518766003800 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 518766003801 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 518766003802 putative dimer interface [polypeptide binding]; other site 518766003803 Nrap protein; Region: Nrap; pfam03813 518766003804 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 518766003805 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 518766003806 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 518766003807 active site 518766003808 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 518766003809 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 518766003810 putative cation:proton antiport protein; Provisional; Region: PRK10669 518766003811 TrkA-N domain; Region: TrkA_N; pfam02254 518766003812 TrkA-C domain; Region: TrkA_C; pfam02080 518766003813 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 518766003814 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 518766003815 NAD binding site [chemical binding]; other site 518766003816 catalytic residues [active] 518766003817 hypothetical protein; Validated; Region: PRK07682 518766003818 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 518766003819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766003820 homodimer interface [polypeptide binding]; other site 518766003821 catalytic residue [active] 518766003822 peptide chain release factor 2; Validated; Region: prfB; PRK00578 518766003823 This domain is found in peptide chain release factors; Region: PCRF; smart00937 518766003824 RF-1 domain; Region: RF-1; pfam00472 518766003825 L-aspartate oxidase; Provisional; Region: PRK09077 518766003826 L-aspartate oxidase; Provisional; Region: PRK06175 518766003827 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 518766003828 ribosome maturation protein RimP; Reviewed; Region: PRK00092 518766003829 Sm and related proteins; Region: Sm_like; cl00259 518766003830 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 518766003831 putative oligomer interface [polypeptide binding]; other site 518766003832 putative RNA binding site [nucleotide binding]; other site 518766003833 transcription termination factor NusA; Region: NusA; TIGR01953 518766003834 NusA N-terminal domain; Region: NusA_N; pfam08529 518766003835 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 518766003836 RNA binding site [nucleotide binding]; other site 518766003837 homodimer interface [polypeptide binding]; other site 518766003838 NusA-like KH domain; Region: KH_5; pfam13184 518766003839 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 518766003840 G-X-X-G motif; other site 518766003841 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 518766003842 translation initiation factor IF-2; Region: IF-2; TIGR00487 518766003843 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 518766003844 G1 box; other site 518766003845 putative GEF interaction site [polypeptide binding]; other site 518766003846 GTP/Mg2+ binding site [chemical binding]; other site 518766003847 Switch I region; other site 518766003848 G2 box; other site 518766003849 G3 box; other site 518766003850 Switch II region; other site 518766003851 G4 box; other site 518766003852 G5 box; other site 518766003853 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 518766003854 Translation-initiation factor 2; Region: IF-2; pfam11987 518766003855 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 518766003856 Ribosome-binding factor A; Region: RBFA; pfam02033 518766003857 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 518766003858 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 518766003859 RNA binding site [nucleotide binding]; other site 518766003860 active site 518766003861 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 518766003862 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 518766003863 active site 518766003864 Riboflavin kinase; Region: Flavokinase; pfam01687 518766003865 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 518766003866 16S/18S rRNA binding site [nucleotide binding]; other site 518766003867 S13e-L30e interaction site [polypeptide binding]; other site 518766003868 25S rRNA binding site [nucleotide binding]; other site 518766003869 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 518766003870 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 518766003871 RNase E interface [polypeptide binding]; other site 518766003872 trimer interface [polypeptide binding]; other site 518766003873 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 518766003874 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 518766003875 RNase E interface [polypeptide binding]; other site 518766003876 trimer interface [polypeptide binding]; other site 518766003877 active site 518766003878 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 518766003879 putative nucleic acid binding region [nucleotide binding]; other site 518766003880 G-X-X-G motif; other site 518766003881 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 518766003882 RNA binding site [nucleotide binding]; other site 518766003883 domain interface; other site 518766003884 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 518766003885 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 518766003886 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 518766003887 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 518766003888 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 518766003889 NAD binding site [chemical binding]; other site 518766003890 substrate binding site [chemical binding]; other site 518766003891 homodimer interface [polypeptide binding]; other site 518766003892 active site 518766003893 ScpA/B protein; Region: ScpA_ScpB; cl00598 518766003894 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 518766003895 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 518766003896 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 518766003897 RNA binding surface [nucleotide binding]; other site 518766003898 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 518766003899 active site 518766003900 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 518766003901 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 518766003902 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 518766003903 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 518766003904 active site 518766003905 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 518766003906 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 518766003907 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 518766003908 active site 518766003909 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 518766003910 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766003911 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 518766003912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766003913 ATP binding site [chemical binding]; other site 518766003914 Mg2+ binding site [ion binding]; other site 518766003915 G-X-G motif; other site 518766003916 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 518766003917 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 518766003918 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 518766003919 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 518766003920 active site 518766003921 DNA binding site [nucleotide binding] 518766003922 Int/Topo IB signature motif; other site 518766003923 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 518766003924 active site 2 [active] 518766003925 active site 1 [active] 518766003926 Domain of unknown function (DUF1886); Region: DUF1886; cl01666 518766003927 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766003928 Uncharacterized conserved protein [Function unknown]; Region: COG1262 518766003929 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 518766003930 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 518766003931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 518766003932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 518766003933 DNA binding site [nucleotide binding] 518766003934 domain linker motif; other site 518766003935 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 518766003936 dimerization interface [polypeptide binding]; other site 518766003937 ligand binding site [chemical binding]; other site 518766003938 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 518766003939 active site 518766003940 ATP binding site [chemical binding]; other site 518766003941 substrate binding site [chemical binding]; other site 518766003942 Predicted amidohydrolase [General function prediction only]; Region: COG0388 518766003943 Pyrococcus horikoshii Ph0642 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Ph0642_like; cd07577 518766003944 putative active site [active] 518766003945 catalytic triad [active] 518766003946 dimer interface [polypeptide binding]; other site 518766003947 putative tetramer interface [polypeptide binding]; other site 518766003948 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 518766003949 MoaE homodimer interface [polypeptide binding]; other site 518766003950 MoaD interaction [polypeptide binding]; other site 518766003951 active site residues [active] 518766003952 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 518766003953 MoaE interaction surface [polypeptide binding]; other site 518766003954 MoeB interaction surface [polypeptide binding]; other site 518766003955 thiocarboxylated glycine; other site 518766003956 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 518766003957 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 518766003958 FtsX-like permease family; Region: FtsX; pfam02687 518766003959 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 518766003960 active site 518766003961 catalytic motif [active] 518766003962 Zn binding site [ion binding]; other site 518766003963 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 518766003964 active site 518766003965 catalytic motif [active] 518766003966 Zn binding site [ion binding]; other site 518766003967 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 518766003968 metal ion-dependent adhesion site (MIDAS); other site 518766003969 Lamin Tail Domain; Region: LTD; pfam00932 518766003970 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 518766003971 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 518766003972 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 518766003973 Clp amino terminal domain; Region: Clp_N; pfam02861 518766003974 Clp amino terminal domain; Region: Clp_N; pfam02861 518766003975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766003976 Walker A motif; other site 518766003977 ATP binding site [chemical binding]; other site 518766003978 Walker B motif; other site 518766003979 arginine finger; other site 518766003980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766003981 Walker A motif; other site 518766003982 ATP binding site [chemical binding]; other site 518766003983 Walker B motif; other site 518766003984 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 518766003985 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 518766003986 active site 518766003987 dimer interface [polypeptide binding]; other site 518766003988 catalytic nucleophile [active] 518766003989 Glyco_18 domain; Region: Glyco_18; smart00636 518766003990 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 518766003991 active site 518766003992 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 518766003993 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 518766003994 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 518766003995 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 518766003996 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 518766003997 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 518766003998 DNA polymerase I; Provisional; Region: PRK05755 518766003999 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 518766004000 active site 518766004001 metal binding site 1 [ion binding]; metal-binding site 518766004002 putative 5' ssDNA interaction site; other site 518766004003 metal binding site 3; metal-binding site 518766004004 metal binding site 2 [ion binding]; metal-binding site 518766004005 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 518766004006 putative DNA binding site [nucleotide binding]; other site 518766004007 putative metal binding site [ion binding]; other site 518766004008 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 518766004009 active site 518766004010 catalytic site [active] 518766004011 substrate binding site [chemical binding]; other site 518766004012 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 518766004013 active site 518766004014 DNA binding site [nucleotide binding] 518766004015 catalytic site [active] 518766004016 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 518766004017 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 518766004018 NAD binding site [chemical binding]; other site 518766004019 substrate binding site [chemical binding]; other site 518766004020 homodimer interface [polypeptide binding]; other site 518766004021 active site 518766004022 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 518766004023 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 518766004024 active site 518766004025 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 518766004026 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 518766004027 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 518766004028 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 518766004029 motif II; other site 518766004030 Fructosamine kinase; Region: Fructosamin_kin; cl17579 518766004031 Phosphotransferase enzyme family; Region: APH; pfam01636 518766004032 Low molecular weight phosphatase family; Region: LMWPc; cd00115 518766004033 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 518766004034 active site 518766004035 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 518766004036 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 518766004037 generic binding surface I; other site 518766004038 generic binding surface II; other site 518766004039 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 518766004040 Beta-lactamase; Region: Beta-lactamase; pfam00144 518766004041 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 518766004042 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 518766004043 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 518766004044 active site 518766004045 putative substrate binding pocket [chemical binding]; other site 518766004046 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 518766004047 D-aminoacylase, C-terminal region; Region: D-aminoacyl_C; pfam07908 518766004048 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 518766004049 Ligand Binding Site [chemical binding]; other site 518766004050 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 518766004051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 518766004052 FeS/SAM binding site; other site 518766004053 HemN C-terminal domain; Region: HemN_C; pfam06969 518766004054 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766004055 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 518766004056 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 518766004057 DNA polymerase II large subunit; Validated; Region: PRK04023 518766004058 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 518766004059 catalytic triad [active] 518766004060 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 518766004061 Cytochrome c; Region: Cytochrom_C; pfam00034 518766004062 MOSC domain; Region: MOSC; pfam03473 518766004063 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 518766004064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 518766004065 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 518766004066 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 518766004067 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 518766004068 dimerization interface [polypeptide binding]; other site 518766004069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766004070 dimer interface [polypeptide binding]; other site 518766004071 phosphorylation site [posttranslational modification] 518766004072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766004073 ATP binding site [chemical binding]; other site 518766004074 Mg2+ binding site [ion binding]; other site 518766004075 G-X-G motif; other site 518766004076 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 518766004077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766004078 active site 518766004079 phosphorylation site [posttranslational modification] 518766004080 intermolecular recognition site; other site 518766004081 dimerization interface [polypeptide binding]; other site 518766004082 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 518766004083 DNA binding site [nucleotide binding] 518766004084 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 518766004085 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 518766004086 Multicopper oxidase; Region: Cu-oxidase; pfam00394 518766004087 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 518766004088 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 518766004089 Predicted metal-binding protein [General function prediction only]; Region: COG3019 518766004090 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 518766004091 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 518766004092 catalytic residues [active] 518766004093 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 518766004094 dimer interface [polypeptide binding]; other site 518766004095 Short C-terminal domain; Region: SHOCT; pfam09851 518766004096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766004097 S-adenosylmethionine binding site [chemical binding]; other site 518766004098 Domain of unknown function DUF302; Region: DUF302; pfam03625 518766004099 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 518766004100 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 518766004101 Multicopper oxidase; Region: Cu-oxidase; pfam00394 518766004102 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 518766004103 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 518766004104 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 518766004105 Zn binding site [ion binding]; other site 518766004106 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 518766004107 Zn binding site [ion binding]; other site 518766004108 Cupin domain; Region: Cupin_2; pfam07883 518766004109 Right handed beta helix region; Region: Beta_helix; pfam13229 518766004110 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766004111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 518766004112 putative substrate translocation pore; other site 518766004113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 518766004114 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 518766004115 metal-binding site [ion binding] 518766004116 mercuric reductase; Region: MerA; TIGR02053 518766004117 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 518766004118 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 518766004119 MerT mercuric transport protein; Region: MerT; cl03578 518766004120 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 518766004121 metal-binding site [ion binding] 518766004122 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 518766004123 dimerization interface [polypeptide binding]; other site 518766004124 putative DNA binding site [nucleotide binding]; other site 518766004125 putative Zn2+ binding site [ion binding]; other site 518766004126 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 518766004127 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 518766004128 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 518766004129 active site 518766004130 Zn binding site [ion binding]; other site 518766004131 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 518766004132 30S subunit binding site; other site 518766004133 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 518766004134 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 518766004135 active site 518766004136 metal binding site [ion binding]; metal-binding site 518766004137 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 518766004138 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 518766004139 E3 interaction surface; other site 518766004140 lipoyl attachment site [posttranslational modification]; other site 518766004141 e3 binding domain; Region: E3_binding; pfam02817 518766004142 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 518766004143 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 518766004144 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 518766004145 alpha subunit interface [polypeptide binding]; other site 518766004146 TPP binding site [chemical binding]; other site 518766004147 heterodimer interface [polypeptide binding]; other site 518766004148 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 518766004149 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 518766004150 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 518766004151 tetramer interface [polypeptide binding]; other site 518766004152 TPP-binding site [chemical binding]; other site 518766004153 heterodimer interface [polypeptide binding]; other site 518766004154 phosphorylation loop region [posttranslational modification] 518766004155 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 518766004156 Ligand binding site; other site 518766004157 Putative Catalytic site; other site 518766004158 DXD motif; other site 518766004159 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 518766004160 putative active site [active] 518766004161 putative metal binding site [ion binding]; other site 518766004162 isocitrate dehydrogenase; Validated; Region: PRK07362 518766004163 isocitrate dehydrogenase; Reviewed; Region: PRK07006 518766004164 Domain of unknown function (DUF3524); Region: DUF3524; pfam12038 518766004165 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766004166 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 518766004167 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 518766004168 Abortive infection C-terminus; Region: Abi_C; pfam14355 518766004169 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 518766004170 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 518766004171 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 518766004172 putative active site [active] 518766004173 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 518766004174 putative NTP binding site [chemical binding]; other site 518766004175 putative nucleic acid binding site [nucleotide binding]; other site 518766004176 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 518766004177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 518766004178 Walker A/P-loop; other site 518766004179 ATP binding site [chemical binding]; other site 518766004180 Q-loop/lid; other site 518766004181 ABC transporter signature motif; other site 518766004182 Walker B; other site 518766004183 D-loop; other site 518766004184 H-loop/switch region; other site 518766004185 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785 518766004186 active site 518766004187 catalytic site [active] 518766004188 substrate binding site [chemical binding]; other site 518766004189 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 518766004190 active site 518766004191 DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417 518766004192 metal-binding site 518766004193 arginine decarboxylase; Provisional; Region: PRK05354 518766004194 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 518766004195 dimer interface [polypeptide binding]; other site 518766004196 active site 518766004197 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 518766004198 catalytic residues [active] 518766004199 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 518766004200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 518766004201 active site 518766004202 dimerization interface [polypeptide binding]; other site 518766004203 Protein of unknown function (DUF429); Region: DUF429; cl12046 518766004204 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 518766004205 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 518766004206 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 518766004207 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 518766004208 NADP binding site [chemical binding]; other site 518766004209 dimer interface [polypeptide binding]; other site 518766004210 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 518766004211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 518766004212 active site 518766004213 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 518766004214 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 518766004215 active site 518766004216 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 518766004217 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 518766004218 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 518766004219 dimer interface [polypeptide binding]; other site 518766004220 ADP-ribose binding site [chemical binding]; other site 518766004221 active site 518766004222 nudix motif; other site 518766004223 metal binding site [ion binding]; metal-binding site 518766004224 methionine sulfoxide reductase B; Provisional; Region: PRK00222 518766004225 SelR domain; Region: SelR; pfam01641 518766004226 acetyl-CoA synthetase; Provisional; Region: PRK00174 518766004227 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 518766004228 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 518766004229 acyl-activating enzyme (AAE) consensus motif; other site 518766004230 putative AMP binding site [chemical binding]; other site 518766004231 putative active site [active] 518766004232 putative CoA binding site [chemical binding]; other site 518766004233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766004234 TPR motif; other site 518766004235 Tetratricopeptide repeat; Region: TPR_16; pfam13432 518766004236 binding surface 518766004237 Tetratricopeptide repeat; Region: TPR_16; pfam13432 518766004238 Family description; Region: VCBS; pfam13517 518766004239 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 518766004240 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 518766004241 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766004242 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 518766004243 putative active site [active] 518766004244 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 518766004245 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 518766004246 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 518766004247 Ligand binding site [chemical binding]; other site 518766004248 Electron transfer flavoprotein domain; Region: ETF; pfam01012 518766004249 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 518766004250 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 518766004251 Ligand Binding Site [chemical binding]; other site 518766004252 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 518766004253 putative oxidoreductase FixC; Provisional; Region: PRK10157 518766004254 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 518766004255 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 518766004256 acyl-coenzyme A oxidase; Region: PLN02526 518766004257 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 518766004258 FAD binding site [chemical binding]; other site 518766004259 substrate binding pocket [chemical binding]; other site 518766004260 catalytic base [active] 518766004261 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766004262 binding surface 518766004263 TPR repeat; Region: TPR_11; pfam13414 518766004264 TPR motif; other site 518766004265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 518766004266 TPR motif; other site 518766004267 binding surface 518766004268 Family description; Region: VCBS; pfam13517 518766004269 Family description; Region: VCBS; pfam13517 518766004270 Family description; Region: VCBS; pfam13517 518766004271 Family description; Region: VCBS; pfam13517 518766004272 Family description; Region: VCBS; pfam13517 518766004273 Family description; Region: VCBS; pfam13517 518766004274 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 518766004275 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 518766004276 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 518766004277 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 518766004278 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 518766004279 lipoyl-biotinyl attachment site [posttranslational modification]; other site 518766004280 HlyD family secretion protein; Region: HlyD_3; pfam13437 518766004281 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 518766004282 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 518766004283 FtsX-like permease family; Region: FtsX; pfam02687 518766004284 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 518766004285 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 518766004286 FtsX-like permease family; Region: FtsX; pfam02687 518766004287 glutamine synthetase, type I; Region: GlnA; TIGR00653 518766004288 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 518766004289 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 518766004290 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 518766004291 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 518766004292 PYR/PP interface [polypeptide binding]; other site 518766004293 dimer interface [polypeptide binding]; other site 518766004294 TPP binding site [chemical binding]; other site 518766004295 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 518766004296 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 518766004297 TPP-binding site [chemical binding]; other site 518766004298 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 518766004299 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 518766004300 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 518766004301 minor groove reading motif; other site 518766004302 helix-hairpin-helix signature motif; other site 518766004303 substrate binding pocket [chemical binding]; other site 518766004304 active site 518766004305 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 518766004306 hypothetical protein; Reviewed; Region: PRK12497 518766004307 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 518766004308 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 518766004309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766004310 dimer interface [polypeptide binding]; other site 518766004311 phosphorylation site [posttranslational modification] 518766004312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766004313 ATP binding site [chemical binding]; other site 518766004314 Mg2+ binding site [ion binding]; other site 518766004315 G-X-G motif; other site 518766004316 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 518766004317 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 518766004318 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 518766004319 GDP-binding site [chemical binding]; other site 518766004320 ACT binding site; other site 518766004321 IMP binding site; other site 518766004322 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 518766004323 anti sigma factor interaction site; other site 518766004324 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 518766004325 regulatory phosphorylation site [posttranslational modification]; other site 518766004326 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 518766004327 Protein export membrane protein; Region: SecD_SecF; pfam02355 518766004328 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 518766004329 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 518766004330 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 518766004331 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 518766004332 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 518766004333 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 518766004334 putative dimer interface [polypeptide binding]; other site 518766004335 putative anticodon binding site; other site 518766004336 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 518766004337 motif 1; other site 518766004338 dimer interface [polypeptide binding]; other site 518766004339 active site 518766004340 motif 2; other site 518766004341 motif 3; other site 518766004342 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766004343 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 518766004344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 518766004345 NAD(P) binding site [chemical binding]; other site 518766004346 active site 518766004347 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 518766004348 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 518766004349 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 518766004350 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 518766004351 TAP-like protein; Region: Abhydrolase_4; pfam08386 518766004352 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 518766004353 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 518766004354 phosphate binding site [ion binding]; other site 518766004355 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 518766004356 active site 518766004357 NTP binding site [chemical binding]; other site 518766004358 metal binding triad [ion binding]; metal-binding site 518766004359 antibiotic binding site [chemical binding]; other site 518766004360 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 518766004361 CoenzymeA binding site [chemical binding]; other site 518766004362 subunit interaction site [polypeptide binding]; other site 518766004363 PHB binding site; other site 518766004364 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 518766004365 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 518766004366 substrate binding site [chemical binding]; other site 518766004367 oxyanion hole (OAH) forming residues; other site 518766004368 trimer interface [polypeptide binding]; other site 518766004369 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 518766004370 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 518766004371 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 518766004372 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 518766004373 dimer interface [polypeptide binding]; other site 518766004374 active site 518766004375 Mgc45594 gene product and other MDR family members; Region: Mgc45594_like; cd08250 518766004376 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 518766004377 NADP binding site [chemical binding]; other site 518766004378 dimer interface [polypeptide binding]; other site 518766004379 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 518766004380 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 518766004381 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 518766004382 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 518766004383 WHG domain; Region: WHG; pfam13305 518766004384 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 518766004385 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 518766004386 ligand binding site [chemical binding]; other site 518766004387 NAD binding site [chemical binding]; other site 518766004388 tetramer interface [polypeptide binding]; other site 518766004389 catalytic site [active] 518766004390 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 518766004391 triosephosphate isomerase; Provisional; Region: PRK14567 518766004392 substrate binding site [chemical binding]; other site 518766004393 dimer interface [polypeptide binding]; other site 518766004394 catalytic triad [active] 518766004395 AhpC/TSA family; Region: AhpC-TSA; pfam00578 518766004396 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 518766004397 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 518766004398 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 518766004399 GatB domain; Region: GatB_Yqey; smart00845 518766004400 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 518766004401 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 518766004402 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 518766004403 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 518766004404 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 518766004405 starch binding outer membrane protein SusD; Region: SusD; cd08977 518766004406 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 518766004407 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766004408 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 518766004409 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 518766004410 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766004411 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 518766004412 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766004413 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 518766004414 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 518766004415 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 518766004416 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 518766004417 catalytic triad [active] 518766004418 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 518766004419 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 518766004420 tetramer interface [polypeptide binding]; other site 518766004421 TPP-binding site [chemical binding]; other site 518766004422 heterodimer interface [polypeptide binding]; other site 518766004423 phosphorylation loop region [posttranslational modification] 518766004424 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 518766004425 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 518766004426 alpha subunit interface [polypeptide binding]; other site 518766004427 TPP binding site [chemical binding]; other site 518766004428 heterodimer interface [polypeptide binding]; other site 518766004429 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 518766004430 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 518766004431 Bacterial sugar transferase; Region: Bac_transf; pfam02397 518766004432 Radical SAM superfamily; Region: Radical_SAM; pfam04055 518766004433 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 518766004434 FeS/SAM binding site; other site 518766004435 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 518766004436 putative active site [active] 518766004437 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 518766004438 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 518766004439 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 518766004440 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 518766004441 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 518766004442 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 518766004443 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 518766004444 putative RNA binding site [nucleotide binding]; other site 518766004445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766004446 S-adenosylmethionine binding site [chemical binding]; other site 518766004447 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 518766004448 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 518766004449 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 518766004450 Na binding site [ion binding]; other site 518766004451 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 518766004452 acetyl-CoA synthetase; Provisional; Region: PRK00174 518766004453 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 518766004454 active site 518766004455 CoA binding site [chemical binding]; other site 518766004456 acyl-activating enzyme (AAE) consensus motif; other site 518766004457 AMP binding site [chemical binding]; other site 518766004458 acetate binding site [chemical binding]; other site 518766004459 PAS domain; Region: PAS; smart00091 518766004460 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 518766004461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766004462 active site 518766004463 phosphorylation site [posttranslational modification] 518766004464 intermolecular recognition site; other site 518766004465 dimerization interface [polypeptide binding]; other site 518766004466 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 518766004467 Na binding site [ion binding]; other site 518766004468 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766004469 dimer interface [polypeptide binding]; other site 518766004470 phosphorylation site [posttranslational modification] 518766004471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766004472 ATP binding site [chemical binding]; other site 518766004473 G-X-G motif; other site 518766004474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 518766004475 dimerization interface [polypeptide binding]; other site 518766004476 putative DNA binding site [nucleotide binding]; other site 518766004477 putative Zn2+ binding site [ion binding]; other site 518766004478 PAS fold; Region: PAS; pfam00989 518766004479 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 518766004480 active site 518766004481 catalytic site [active] 518766004482 substrate binding site [chemical binding]; other site 518766004483 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 518766004484 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 518766004485 P-loop; other site 518766004486 Magnesium ion binding site [ion binding]; other site 518766004487 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 518766004488 Magnesium ion binding site [ion binding]; other site 518766004489 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 518766004490 putative active site [active] 518766004491 catalytic triad [active] 518766004492 putative dimer interface [polypeptide binding]; other site 518766004493 Maf-like protein; Region: Maf; pfam02545 518766004494 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 518766004495 active site 518766004496 dimer interface [polypeptide binding]; other site 518766004497 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 518766004498 catalytic triad [active] 518766004499 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 518766004500 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 518766004501 putative active site; other site 518766004502 catalytic triad [active] 518766004503 putative dimer interface [polypeptide binding]; other site 518766004504 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 518766004505 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 518766004506 HDOD domain; Region: HDOD; pfam08668 518766004507 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 518766004508 homooctamer interface [polypeptide binding]; other site 518766004509 active site 518766004510 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 518766004511 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 518766004512 substrate binding site [chemical binding]; other site 518766004513 ATP binding site [chemical binding]; other site 518766004514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766004515 binding surface 518766004516 TPR motif; other site 518766004517 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 518766004518 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766004519 binding surface 518766004520 TPR motif; other site 518766004521 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 518766004522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766004523 binding surface 518766004524 TPR motif; other site 518766004525 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 518766004526 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766004527 binding surface 518766004528 TPR motif; other site 518766004529 Tetratricopeptide repeat; Region: TPR_12; pfam13424 518766004530 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766004531 binding surface 518766004532 TPR repeat; Region: TPR_11; pfam13414 518766004533 TPR motif; other site 518766004534 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 518766004535 Tetratricopeptide repeat; Region: TPR_12; pfam13424 518766004536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766004537 binding surface 518766004538 TPR motif; other site 518766004539 Tetratricopeptide repeat; Region: TPR_12; pfam13424 518766004540 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766004541 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 518766004542 IHF dimer interface [polypeptide binding]; other site 518766004543 IHF - DNA interface [nucleotide binding]; other site 518766004544 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 518766004545 IHF dimer interface [polypeptide binding]; other site 518766004546 Sporulation related domain; Region: SPOR; pfam05036 518766004547 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 518766004548 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 518766004549 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 518766004550 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 518766004551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766004552 Walker A motif; other site 518766004553 ATP binding site [chemical binding]; other site 518766004554 Walker B motif; other site 518766004555 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 518766004556 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 518766004557 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 518766004558 Transcriptional regulators [Transcription]; Region: PurR; COG1609 518766004559 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 518766004560 DNA binding site [nucleotide binding] 518766004561 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 518766004562 dimerization interface [polypeptide binding]; other site 518766004563 ligand binding site [chemical binding]; other site 518766004564 D-mannonate oxidoreductase; Provisional; Region: PRK08277 518766004565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 518766004566 NAD(P) binding site [chemical binding]; other site 518766004567 active site 518766004568 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 518766004569 active site 518766004570 DNA binding site [nucleotide binding] 518766004571 Tetratricopeptide repeat; Region: TPR_12; pfam13424 518766004572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766004573 TPR motif; other site 518766004574 binding surface 518766004575 Tetratricopeptide repeat; Region: TPR_12; pfam13424 518766004576 putative acyltransferase; Provisional; Region: PRK05790 518766004577 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 518766004578 dimer interface [polypeptide binding]; other site 518766004579 active site 518766004580 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 518766004581 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 518766004582 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 518766004583 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 518766004584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 518766004585 motif II; other site 518766004586 ABC1 family; Region: ABC1; cl17513 518766004587 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 518766004588 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 518766004589 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 518766004590 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 518766004591 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 518766004592 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 518766004593 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 518766004594 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 518766004595 trimer interface [polypeptide binding]; other site 518766004596 putative metal binding site [ion binding]; other site 518766004597 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 518766004598 MutS domain I; Region: MutS_I; pfam01624 518766004599 MutS domain II; Region: MutS_II; pfam05188 518766004600 MutS domain III; Region: MutS_III; pfam05192 518766004601 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 518766004602 Walker A/P-loop; other site 518766004603 ATP binding site [chemical binding]; other site 518766004604 Q-loop/lid; other site 518766004605 ABC transporter signature motif; other site 518766004606 Walker B; other site 518766004607 D-loop; other site 518766004608 H-loop/switch region; other site 518766004609 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 518766004610 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 518766004611 Phenylacetic acid degradation B; Region: PaaB; cl01371 518766004612 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 518766004613 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 518766004614 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 518766004615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 518766004616 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 518766004617 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 518766004618 tetramer interface [polypeptide binding]; other site 518766004619 TPP-binding site [chemical binding]; other site 518766004620 heterodimer interface [polypeptide binding]; other site 518766004621 phosphorylation loop region [posttranslational modification] 518766004622 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 518766004623 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 518766004624 alpha subunit interface [polypeptide binding]; other site 518766004625 TPP binding site [chemical binding]; other site 518766004626 heterodimer interface [polypeptide binding]; other site 518766004627 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 518766004628 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 518766004629 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 518766004630 substrate binding site [chemical binding]; other site 518766004631 oxyanion hole (OAH) forming residues; other site 518766004632 trimer interface [polypeptide binding]; other site 518766004633 enoyl-CoA hydratase; Provisional; Region: PRK08140 518766004634 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 518766004635 substrate binding site [chemical binding]; other site 518766004636 oxyanion hole (OAH) forming residues; other site 518766004637 trimer interface [polypeptide binding]; other site 518766004638 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 518766004639 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 518766004640 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 518766004641 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 518766004642 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 518766004643 CoenzymeA binding site [chemical binding]; other site 518766004644 subunit interaction site [polypeptide binding]; other site 518766004645 PHB binding site; other site 518766004646 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 518766004647 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 518766004648 dimer interface [polypeptide binding]; other site 518766004649 active site 518766004650 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 518766004651 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 518766004652 putative trimer interface [polypeptide binding]; other site 518766004653 putative CoA binding site [chemical binding]; other site 518766004654 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 518766004655 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 518766004656 substrate binding site [chemical binding]; other site 518766004657 dimer interface [polypeptide binding]; other site 518766004658 NADP binding site [chemical binding]; other site 518766004659 catalytic residues [active] 518766004660 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 518766004661 active site 2 [active] 518766004662 active site 1 [active] 518766004663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 518766004664 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 518766004665 putative active site [active] 518766004666 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 518766004667 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 518766004668 motif 1; other site 518766004669 active site 518766004670 motif 2; other site 518766004671 motif 3; other site 518766004672 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 518766004673 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 518766004674 active site 518766004675 NTP binding site [chemical binding]; other site 518766004676 metal binding triad [ion binding]; metal-binding site 518766004677 antibiotic binding site [chemical binding]; other site 518766004678 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 518766004679 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 518766004680 D-pathway; other site 518766004681 Low-spin heme binding site [chemical binding]; other site 518766004682 Putative water exit pathway; other site 518766004683 Binuclear center (active site) [active] 518766004684 K-pathway; other site 518766004685 Putative proton exit pathway; other site 518766004686 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 518766004687 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 518766004688 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 518766004689 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 518766004690 active site 518766004691 HIGH motif; other site 518766004692 KMSKS motif; other site 518766004693 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 518766004694 tRNA binding surface [nucleotide binding]; other site 518766004695 anticodon binding site; other site 518766004696 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 518766004697 dimer interface [polypeptide binding]; other site 518766004698 putative tRNA-binding site [nucleotide binding]; other site 518766004699 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 518766004700 putative active site pocket [active] 518766004701 4-fold oligomerization interface [polypeptide binding]; other site 518766004702 metal binding residues [ion binding]; metal-binding site 518766004703 3-fold/trimer interface [polypeptide binding]; other site 518766004704 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 518766004705 pyrroline-5-carboxylate reductase; Region: PLN02688 518766004706 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 518766004707 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 518766004708 putative active site [active] 518766004709 oxyanion strand; other site 518766004710 catalytic triad [active] 518766004711 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 518766004712 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 518766004713 catalytic residues [active] 518766004714 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 518766004715 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 518766004716 substrate binding site [chemical binding]; other site 518766004717 glutamase interaction surface [polypeptide binding]; other site 518766004718 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 518766004719 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 518766004720 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 518766004721 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 518766004722 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 518766004723 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 518766004724 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 518766004725 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 518766004726 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 518766004727 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 518766004728 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 518766004729 catalytic residue [active] 518766004730 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 518766004731 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 518766004732 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 518766004733 active site 518766004734 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 518766004735 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 518766004736 active site 518766004737 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 518766004738 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 518766004739 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 518766004740 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 518766004741 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 518766004742 Walker A/P-loop; other site 518766004743 ATP binding site [chemical binding]; other site 518766004744 Q-loop/lid; other site 518766004745 ABC transporter signature motif; other site 518766004746 Walker B; other site 518766004747 D-loop; other site 518766004748 H-loop/switch region; other site 518766004749 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 518766004750 urocanate hydratase; Provisional; Region: PRK05414 518766004751 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 518766004752 active sites [active] 518766004753 tetramer interface [polypeptide binding]; other site 518766004754 imidazolonepropionase; Validated; Region: PRK09356 518766004755 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 518766004756 active site 518766004757 agmatinase; Region: agmatinase; TIGR01230 518766004758 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 518766004759 putative active site [active] 518766004760 putative metal binding site [ion binding]; other site 518766004761 putative peptidase; Provisional; Region: PRK11649 518766004762 Peptidase family M23; Region: Peptidase_M23; pfam01551 518766004763 phytoene desaturase; Region: crtI_fam; TIGR02734 518766004764 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 518766004765 hydroxyglutarate oxidase; Provisional; Region: PRK11728 518766004766 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 518766004767 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 518766004768 putative acyl-acceptor binding pocket; other site 518766004769 Protein of unknown function (DUF422); Region: DUF422; pfam04240 518766004770 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 518766004771 catalytic residues [active] 518766004772 substrate binding pocket [chemical binding]; other site 518766004773 substrate-Mg2+ binding site; other site 518766004774 aspartate-rich region 1; other site 518766004775 aspartate-rich region 2; other site 518766004776 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 518766004777 DNA binding residues [nucleotide binding] 518766004778 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 518766004779 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 518766004780 classical (c) SDRs; Region: SDR_c; cd05233 518766004781 NAD(P) binding site [chemical binding]; other site 518766004782 active site 518766004783 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 518766004784 DNA photolyase; Region: DNA_photolyase; pfam00875 518766004785 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 518766004786 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 518766004787 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 518766004788 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 518766004789 putative NAD(P) binding site [chemical binding]; other site 518766004790 putative active site [active] 518766004791 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 518766004792 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 518766004793 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 518766004794 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 518766004795 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 518766004796 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 518766004797 Protein of unknown function (DUF523); Region: DUF523; pfam04463 518766004798 Uncharacterized conserved protein [Function unknown]; Region: COG3272 518766004799 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 518766004800 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 518766004801 E-class dimer interface [polypeptide binding]; other site 518766004802 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 518766004803 P-class dimer interface [polypeptide binding]; other site 518766004804 active site 518766004805 Cu2+ binding site [ion binding]; other site 518766004806 Zn2+ binding site [ion binding]; other site 518766004807 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 518766004808 catalytic nucleophile [active] 518766004809 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 518766004810 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766004811 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 518766004812 DNA binding residues [nucleotide binding] 518766004813 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 518766004814 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 518766004815 ligand binding site [chemical binding]; other site 518766004816 flexible hinge region; other site 518766004817 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 518766004818 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 518766004819 metal binding triad; other site 518766004820 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 518766004821 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 518766004822 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 518766004823 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 518766004824 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 518766004825 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 518766004826 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 518766004827 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 518766004828 dimer interface [polypeptide binding]; other site 518766004829 motif 1; other site 518766004830 active site 518766004831 motif 2; other site 518766004832 motif 3; other site 518766004833 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 518766004834 anticodon binding site; other site 518766004835 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 518766004836 active site 518766004837 phosphorylation site [posttranslational modification] 518766004838 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 518766004839 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 518766004840 RNA binding surface [nucleotide binding]; other site 518766004841 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 518766004842 active site 518766004843 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 518766004844 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 518766004845 metal binding site [ion binding]; metal-binding site 518766004846 dimer interface [polypeptide binding]; other site 518766004847 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 518766004848 CHASE3 domain; Region: CHASE3; pfam05227 518766004849 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 518766004850 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 518766004851 dimerization interface [polypeptide binding]; other site 518766004852 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 518766004853 dimerization interface [polypeptide binding]; other site 518766004854 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 518766004855 dimer interface [polypeptide binding]; other site 518766004856 putative CheW interface [polypeptide binding]; other site 518766004857 argininosuccinate lyase; Provisional; Region: PRK00855 518766004858 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 518766004859 active sites [active] 518766004860 tetramer interface [polypeptide binding]; other site 518766004861 GYD domain; Region: GYD; cl01743 518766004862 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 518766004863 Domain of unknown function (DUF303); Region: DUF303; pfam03629 518766004864 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 518766004865 Domain of unknown function (DUF303); Region: DUF303; pfam03629 518766004866 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 518766004867 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 518766004868 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 518766004869 active site 518766004870 catalytic site [active] 518766004871 substrate binding site [chemical binding]; other site 518766004872 CRISPR-associated protein (Cas_Cas02710); Region: Cas_Cas02710; pfam09670 518766004873 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09747 518766004874 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 518766004875 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 518766004876 DNA-binding site [nucleotide binding]; DNA binding site 518766004877 RNA-binding motif; other site 518766004878 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 518766004879 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 518766004880 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 518766004881 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 518766004882 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 518766004883 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 518766004884 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 518766004885 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 518766004886 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 518766004887 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 518766004888 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 518766004889 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 518766004890 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 518766004891 Predicted transcriptional regulator [Transcription]; Region: COG2378 518766004892 HTH domain; Region: HTH_11; pfam08279 518766004893 WYL domain; Region: WYL; pfam13280 518766004894 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 518766004895 metal binding triad [ion binding]; metal-binding site 518766004896 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 518766004897 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 518766004898 active site 518766004899 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 518766004900 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 518766004901 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 518766004902 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 518766004903 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 518766004904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 518766004905 Walker A/P-loop; other site 518766004906 ATP binding site [chemical binding]; other site 518766004907 Q-loop/lid; other site 518766004908 ABC transporter signature motif; other site 518766004909 Walker B; other site 518766004910 D-loop; other site 518766004911 H-loop/switch region; other site 518766004912 Methyltransferase domain; Region: Methyltransf_23; pfam13489 518766004913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766004914 S-adenosylmethionine binding site [chemical binding]; other site 518766004915 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 518766004916 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 518766004917 NAD-dependent deacetylase; Provisional; Region: PRK05333 518766004918 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 518766004919 NAD+ binding site [chemical binding]; other site 518766004920 substrate binding site [chemical binding]; other site 518766004921 Zn binding site [ion binding]; other site 518766004922 Protein of unknown function DUF99; Region: DUF99; pfam01949 518766004923 hypothetical protein; Provisional; Region: PRK00766 518766004924 Acetyl-CoA acetyltransferase [Lipid metabolism]; Region: PaaJ; COG0183 518766004925 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 518766004926 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 518766004927 nucleotide binding site [chemical binding]; other site 518766004928 substrate binding site [chemical binding]; other site 518766004929 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935 518766004930 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 518766004931 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 518766004932 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 518766004933 catalytic residue [active] 518766004934 dihydrodipicolinate reductase; Provisional; Region: PRK00048 518766004935 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 518766004936 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 518766004937 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 518766004938 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 518766004939 dimer interface [polypeptide binding]; other site 518766004940 active site 518766004941 catalytic residue [active] 518766004942 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 518766004943 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 518766004944 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 518766004945 trimer interface [polypeptide binding]; other site 518766004946 active site 518766004947 substrate binding site [chemical binding]; other site 518766004948 CoA binding site [chemical binding]; other site 518766004949 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 518766004950 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 518766004951 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 518766004952 protoporphyrinogen oxidase; Region: PLN02576 518766004953 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 518766004954 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 518766004955 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 518766004956 homodimer interface [polypeptide binding]; other site 518766004957 substrate-cofactor binding pocket; other site 518766004958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766004959 catalytic residue [active] 518766004960 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 518766004961 active site 518766004962 SAM binding site [chemical binding]; other site 518766004963 homodimer interface [polypeptide binding]; other site 518766004964 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 518766004965 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 518766004966 OsmC-like protein; Region: OsmC; pfam02566 518766004967 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 518766004968 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 518766004969 active site residue [active] 518766004970 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 518766004971 active site residue [active] 518766004972 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 518766004973 putative CoA binding site [chemical binding]; other site 518766004974 putative trimer interface [polypeptide binding]; other site 518766004975 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 518766004976 putative trimer interface [polypeptide binding]; other site 518766004977 putative active site [active] 518766004978 putative substrate binding site [chemical binding]; other site 518766004979 putative CoA binding site [chemical binding]; other site 518766004980 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 518766004981 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 518766004982 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 518766004983 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 518766004984 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 518766004985 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 518766004986 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 518766004987 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 518766004988 dimer interface [polypeptide binding]; other site 518766004989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766004990 catalytic residue [active] 518766004991 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 518766004992 MPN+ (JAMM) motif; other site 518766004993 Zinc-binding site [ion binding]; other site 518766004994 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 518766004995 MoaE interaction surface [polypeptide binding]; other site 518766004996 thiocarboxylated glycine; other site 518766004997 hypothetical protein; Validated; Region: PRK07411 518766004998 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 518766004999 ATP binding site [chemical binding]; other site 518766005000 substrate interface [chemical binding]; other site 518766005001 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 518766005002 active site residue [active] 518766005003 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 518766005004 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 518766005005 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 518766005006 active site 518766005007 nucleophile elbow; other site 518766005008 putative alpha-glucosidase; Provisional; Region: PRK10658 518766005009 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 518766005010 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 518766005011 trimer interface [polypeptide binding]; other site 518766005012 active site 518766005013 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 518766005014 catalytic site [active] 518766005015 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 518766005016 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 518766005017 Tetratricopeptide repeat; Region: TPR_12; pfam13424 518766005018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005019 binding surface 518766005020 TPR motif; other site 518766005021 TPR repeat; Region: TPR_11; pfam13414 518766005022 enolase; Provisional; Region: eno; PRK00077 518766005023 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 518766005024 dimer interface [polypeptide binding]; other site 518766005025 metal binding site [ion binding]; metal-binding site 518766005026 substrate binding pocket [chemical binding]; other site 518766005027 Septum formation initiator; Region: DivIC; pfam04977 518766005028 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 518766005029 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 518766005030 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 518766005031 nucleotide binding site [chemical binding]; other site 518766005032 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 518766005033 BON domain; Region: BON; pfam04972 518766005034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 518766005035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 518766005036 Coenzyme A binding pocket [chemical binding]; other site 518766005037 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 518766005038 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 518766005039 CoA-ligase; Region: Ligase_CoA; pfam00549 518766005040 Predicted permeases [General function prediction only]; Region: COG0795 518766005041 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 518766005042 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 518766005043 PAS fold; Region: PAS_4; pfam08448 518766005044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766005045 ATP binding site [chemical binding]; other site 518766005046 Mg2+ binding site [ion binding]; other site 518766005047 G-X-G motif; other site 518766005048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766005049 Response regulator receiver domain; Region: Response_reg; pfam00072 518766005050 active site 518766005051 phosphorylation site [posttranslational modification] 518766005052 intermolecular recognition site; other site 518766005053 dimerization interface [polypeptide binding]; other site 518766005054 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 518766005055 Found in ATP-dependent protease La (LON); Region: LON; smart00464 518766005056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766005057 Walker A motif; other site 518766005058 ATP binding site [chemical binding]; other site 518766005059 Walker B motif; other site 518766005060 arginine finger; other site 518766005061 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 518766005062 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 518766005063 ABC transporter F family; Provisional; Region: PLN03073 518766005064 GTPase RsgA; Reviewed; Region: PRK00098 518766005065 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 518766005066 RNA binding site [nucleotide binding]; other site 518766005067 homodimer interface [polypeptide binding]; other site 518766005068 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 518766005069 GTPase/Zn-binding domain interface [polypeptide binding]; other site 518766005070 GTP/Mg2+ binding site [chemical binding]; other site 518766005071 G4 box; other site 518766005072 G5 box; other site 518766005073 G1 box; other site 518766005074 Switch I region; other site 518766005075 G2 box; other site 518766005076 G3 box; other site 518766005077 Switch II region; other site 518766005078 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 518766005079 Two component regulator propeller; Region: Reg_prop; pfam07494 518766005080 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 518766005081 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 518766005082 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cd00890 518766005083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766005084 dimer interface [polypeptide binding]; other site 518766005085 phosphorylation site [posttranslational modification] 518766005086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766005087 ATP binding site [chemical binding]; other site 518766005088 Mg2+ binding site [ion binding]; other site 518766005089 G-X-G motif; other site 518766005090 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 518766005091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766005092 active site 518766005093 phosphorylation site [posttranslational modification] 518766005094 intermolecular recognition site; other site 518766005095 dimerization interface [polypeptide binding]; other site 518766005096 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 518766005097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766005098 active site 518766005099 phosphorylation site [posttranslational modification] 518766005100 intermolecular recognition site; other site 518766005101 dimerization interface [polypeptide binding]; other site 518766005102 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 518766005103 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 518766005104 active site 518766005105 interdomain interaction site; other site 518766005106 putative metal-binding site [ion binding]; other site 518766005107 nucleotide binding site [chemical binding]; other site 518766005108 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 518766005109 domain I; other site 518766005110 phosphate binding site [ion binding]; other site 518766005111 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 518766005112 domain II; other site 518766005113 domain III; other site 518766005114 nucleotide binding site [chemical binding]; other site 518766005115 DNA binding groove [nucleotide binding] 518766005116 catalytic site [active] 518766005117 domain IV; other site 518766005118 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 518766005119 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 518766005120 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 518766005121 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 518766005122 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 518766005123 active site 518766005124 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 518766005125 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 518766005126 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 518766005127 dimer interface [polypeptide binding]; other site 518766005128 active site 518766005129 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 518766005130 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 518766005131 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 518766005132 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 518766005133 substrate binding site [chemical binding]; other site 518766005134 oxyanion hole (OAH) forming residues; other site 518766005135 trimer interface [polypeptide binding]; other site 518766005136 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 518766005137 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 518766005138 acyl-activating enzyme (AAE) consensus motif; other site 518766005139 putative AMP binding site [chemical binding]; other site 518766005140 putative active site [active] 518766005141 putative CoA binding site [chemical binding]; other site 518766005142 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 518766005143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 518766005144 WHG domain; Region: WHG; pfam13305 518766005145 multifunctional aminopeptidase A; Provisional; Region: PRK00913 518766005146 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 518766005147 interface (dimer of trimers) [polypeptide binding]; other site 518766005148 Substrate-binding/catalytic site; other site 518766005149 Zn-binding sites [ion binding]; other site 518766005150 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 518766005151 DHH family; Region: DHH; pfam01368 518766005152 DHHA1 domain; Region: DHHA1; pfam02272 518766005153 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 518766005154 thiamine phosphate binding site [chemical binding]; other site 518766005155 active site 518766005156 pyrophosphate binding site [ion binding]; other site 518766005157 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 518766005158 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 518766005159 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 518766005160 SLBB domain; Region: SLBB; pfam10531 518766005161 SLBB domain; Region: SLBB; pfam10531 518766005162 SLBB domain; Region: SLBB; pfam10531 518766005163 SLBB domain; Region: SLBB; pfam10531 518766005164 EamA-like transporter family; Region: EamA; pfam00892 518766005165 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 518766005166 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 518766005167 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 518766005168 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 518766005169 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 518766005170 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 518766005171 C-terminal peptidase (prc); Region: prc; TIGR00225 518766005172 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 518766005173 protein binding site [polypeptide binding]; other site 518766005174 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 518766005175 Catalytic dyad [active] 518766005176 hypothetical protein; Provisional; Region: PRK08609 518766005177 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 518766005178 metal binding triad [ion binding]; metal-binding site 518766005179 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 518766005180 active site 518766005181 Penicillin amidase; Region: Penicil_amidase; pfam01804 518766005182 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 518766005183 active site 518766005184 Zn binding site [ion binding]; other site 518766005185 Colicin V production protein; Region: Colicin_V; pfam02674 518766005186 Yqey-like protein; Region: YqeY; pfam09424 518766005187 PQQ-like domain; Region: PQQ_2; pfam13360 518766005188 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 518766005189 Trp docking motif [polypeptide binding]; other site 518766005190 active site 518766005191 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 518766005192 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 518766005193 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766005194 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766005195 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766005196 Surface antigen; Region: Bac_surface_Ag; pfam01103 518766005197 Suppression of tumorigenicity 7; Region: ST7; cd11557 518766005198 Trehalose utilisation; Region: ThuA; pfam06283 518766005199 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 518766005200 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 518766005201 Metal-binding active site; metal-binding site 518766005202 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 518766005203 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 518766005204 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 518766005205 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 518766005206 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 518766005207 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 518766005208 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 518766005209 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 518766005210 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 518766005211 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 518766005212 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 518766005213 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 518766005214 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 518766005215 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 518766005216 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 518766005217 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 518766005218 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 518766005219 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 518766005220 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 518766005221 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 518766005222 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 518766005223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 518766005224 TPR repeat; Region: TPR_11; pfam13414 518766005225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005226 binding surface 518766005227 TPR motif; other site 518766005228 TPR repeat; Region: TPR_11; pfam13414 518766005229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005230 binding surface 518766005231 TPR motif; other site 518766005232 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 518766005233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005234 TPR repeat; Region: TPR_11; pfam13414 518766005235 TPR motif; other site 518766005236 binding surface 518766005237 TPR repeat; Region: TPR_11; pfam13414 518766005238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005239 binding surface 518766005240 TPR motif; other site 518766005241 TPR repeat; Region: TPR_11; pfam13414 518766005242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005243 binding surface 518766005244 TPR motif; other site 518766005245 TPR repeat; Region: TPR_11; pfam13414 518766005246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005247 binding surface 518766005248 TPR motif; other site 518766005249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005250 binding surface 518766005251 TPR motif; other site 518766005252 Family description; Region: VCBS; pfam13517 518766005253 Family description; Region: VCBS; pfam13517 518766005254 Family description; Region: VCBS; pfam13517 518766005255 Family description; Region: VCBS; pfam13517 518766005256 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 518766005257 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 518766005258 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766005259 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766005260 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 518766005261 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 518766005262 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766005263 Family description; Region: VCBS; pfam13517 518766005264 Family description; Region: VCBS; pfam13517 518766005265 Family description; Region: VCBS; pfam13517 518766005266 Family description; Region: VCBS; pfam13517 518766005267 Family description; Region: VCBS; pfam13517 518766005268 Family description; Region: VCBS; pfam13517 518766005269 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 518766005270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005271 TPR motif; other site 518766005272 binding surface 518766005273 TPR repeat; Region: TPR_11; pfam13414 518766005274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005275 binding surface 518766005276 TPR motif; other site 518766005277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005278 binding surface 518766005279 TPR motif; other site 518766005280 TPR repeat; Region: TPR_11; pfam13414 518766005281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005282 TPR motif; other site 518766005283 binding surface 518766005284 Family description; Region: VCBS; pfam13517 518766005285 Family description; Region: VCBS; pfam13517 518766005286 Family description; Region: VCBS; pfam13517 518766005287 Family description; Region: VCBS; pfam13517 518766005288 Family description; Region: VCBS; pfam13517 518766005289 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 518766005290 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 518766005291 TPR repeat; Region: TPR_11; pfam13414 518766005292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005293 binding surface 518766005294 TPR motif; other site 518766005295 TPR repeat; Region: TPR_11; pfam13414 518766005296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005297 binding surface 518766005298 TPR motif; other site 518766005299 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 518766005300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005301 binding surface 518766005302 TPR motif; other site 518766005303 TPR repeat; Region: TPR_11; pfam13414 518766005304 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766005305 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766005306 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 518766005307 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766005308 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 518766005309 Family description; Region: VCBS; pfam13517 518766005310 Family description; Region: VCBS; pfam13517 518766005311 Family description; Region: VCBS; pfam13517 518766005312 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 518766005313 Family description; Region: VCBS; pfam13517 518766005314 Family description; Region: VCBS; pfam13517 518766005315 Family description; Region: VCBS; pfam13517 518766005316 Family description; Region: VCBS; pfam13517 518766005317 Family description; Region: VCBS; pfam13517 518766005318 Family description; Region: VCBS; pfam13517 518766005319 Family description; Region: VCBS; pfam13517 518766005320 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 518766005321 Family description; Region: VCBS; pfam13517 518766005322 Family description; Region: VCBS; pfam13517 518766005323 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 518766005324 starch binding outer membrane protein SusD; Region: SusD; cl17845 518766005325 SusD family; Region: SusD; pfam07980 518766005326 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 518766005327 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766005328 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766005329 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 518766005330 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 518766005331 Protein of unknown function, DUF608; Region: DUF608; pfam04685 518766005332 Uncharacterized conserved protein [Function unknown]; Region: COG2361 518766005333 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 518766005334 active site 518766005335 NTP binding site [chemical binding]; other site 518766005336 metal binding triad [ion binding]; metal-binding site 518766005337 antibiotic binding site [chemical binding]; other site 518766005338 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 518766005339 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 518766005340 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 518766005341 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 518766005342 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 518766005343 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 518766005344 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 518766005345 Walker A/P-loop; other site 518766005346 ATP binding site [chemical binding]; other site 518766005347 Q-loop/lid; other site 518766005348 ABC transporter signature motif; other site 518766005349 Walker B; other site 518766005350 D-loop; other site 518766005351 H-loop/switch region; other site 518766005352 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 518766005353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 518766005354 Protein of unknown function (DUF433); Region: DUF433; pfam04255 518766005355 alpha-glucosidase; Provisional; Region: PRK10137 518766005356 Trehalase; Region: Trehalase; cl17346 518766005357 Nudix hydrolase homolog; Region: PLN02791 518766005358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 518766005359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 518766005360 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 518766005361 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 518766005362 HlyD family secretion protein; Region: HlyD_3; pfam13437 518766005363 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 518766005364 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 518766005365 Walker A/P-loop; other site 518766005366 ATP binding site [chemical binding]; other site 518766005367 Q-loop/lid; other site 518766005368 ABC transporter signature motif; other site 518766005369 Walker B; other site 518766005370 D-loop; other site 518766005371 H-loop/switch region; other site 518766005372 Outer membrane efflux protein; Region: OEP; pfam02321 518766005373 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 518766005374 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 518766005375 Walker A/P-loop; other site 518766005376 ATP binding site [chemical binding]; other site 518766005377 Q-loop/lid; other site 518766005378 ABC transporter signature motif; other site 518766005379 Walker B; other site 518766005380 D-loop; other site 518766005381 H-loop/switch region; other site 518766005382 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 518766005383 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 518766005384 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 518766005385 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 518766005386 tellurium resistance terB-like protein; Region: terB_like; cl11965 518766005387 metal binding site [ion binding]; metal-binding site 518766005388 tellurium resistance terB-like protein; Region: terB_like; cd07177 518766005389 metal binding site [ion binding]; metal-binding site 518766005390 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 518766005391 CoA binding domain; Region: CoA_binding_2; pfam13380 518766005392 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 518766005393 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 518766005394 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 518766005395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 518766005396 Coenzyme A binding pocket [chemical binding]; other site 518766005397 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 518766005398 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 518766005399 active site 518766005400 substrate binding site [chemical binding]; other site 518766005401 metal binding site [ion binding]; metal-binding site 518766005402 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 518766005403 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 518766005404 protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473 518766005405 UbiA prenyltransferase family; Region: UbiA; pfam01040 518766005406 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 518766005407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 518766005408 Walker A/P-loop; other site 518766005409 ATP binding site [chemical binding]; other site 518766005410 Q-loop/lid; other site 518766005411 ABC transporter signature motif; other site 518766005412 Walker B; other site 518766005413 D-loop; other site 518766005414 H-loop/switch region; other site 518766005415 ABC-2 type transporter; Region: ABC2_membrane; cl17235 518766005416 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 518766005417 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 518766005418 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 518766005419 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 518766005420 active site 518766005421 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766005422 dimer interface [polypeptide binding]; other site 518766005423 phosphorylation site [posttranslational modification] 518766005424 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 518766005425 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 518766005426 quinolinate synthetase; Provisional; Region: PRK09375 518766005427 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 518766005428 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 518766005429 Walker A/P-loop; other site 518766005430 ATP binding site [chemical binding]; other site 518766005431 Q-loop/lid; other site 518766005432 ABC transporter signature motif; other site 518766005433 Walker B; other site 518766005434 D-loop; other site 518766005435 H-loop/switch region; other site 518766005436 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 518766005437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766005438 active site 518766005439 phosphorylation site [posttranslational modification] 518766005440 intermolecular recognition site; other site 518766005441 dimerization interface [polypeptide binding]; other site 518766005442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766005443 Walker A motif; other site 518766005444 ATP binding site [chemical binding]; other site 518766005445 Walker B motif; other site 518766005446 arginine finger; other site 518766005447 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 518766005448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 518766005449 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 518766005450 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 518766005451 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 518766005452 Phosphoglycerate kinase; Region: PGK; pfam00162 518766005453 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 518766005454 substrate binding site [chemical binding]; other site 518766005455 hinge regions; other site 518766005456 ADP binding site [chemical binding]; other site 518766005457 catalytic site [active] 518766005458 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 518766005459 Mechanosensitive ion channel; Region: MS_channel; pfam00924 518766005460 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 518766005461 Amidinotransferase; Region: Amidinotransf; pfam02274 518766005462 prephenate dehydrogenase; Validated; Region: PRK06545 518766005463 prephenate dehydrogenase; Validated; Region: PRK08507 518766005464 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 518766005465 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 518766005466 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 518766005467 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 518766005468 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 518766005469 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 518766005470 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 518766005471 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 518766005472 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 518766005473 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 518766005474 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 518766005475 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 518766005476 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 518766005477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766005478 S-adenosylmethionine binding site [chemical binding]; other site 518766005479 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 518766005480 classical (c) SDRs; Region: SDR_c; cd05233 518766005481 NAD(P) binding site [chemical binding]; other site 518766005482 active site 518766005483 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl17183 518766005484 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 518766005485 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 518766005486 High potential iron-sulfur protein; Region: HIPIP; pfam01355 518766005487 Acylphosphatase; Region: Acylphosphatase; pfam00708 518766005488 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 518766005489 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 518766005490 active site 518766005491 catalytic site [active] 518766005492 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 518766005493 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 518766005494 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 518766005495 putative catalytic residue [active] 518766005496 Peptidase family M48; Region: Peptidase_M48; cl12018 518766005497 Tetratricopeptide repeat; Region: TPR_12; pfam13424 518766005498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005499 binding surface 518766005500 TPR motif; other site 518766005501 Repair protein; Region: Repair_PSII; pfam04536 518766005502 LemA family; Region: LemA; cl00742 518766005503 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 518766005504 C-terminal peptidase (prc); Region: prc; TIGR00225 518766005505 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 518766005506 protein binding site [polypeptide binding]; other site 518766005507 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 518766005508 Catalytic dyad [active] 518766005509 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 518766005510 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 518766005511 putative dimer interface [polypeptide binding]; other site 518766005512 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 518766005513 PhoU domain; Region: PhoU; pfam01895 518766005514 PhoU domain; Region: PhoU; pfam01895 518766005515 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 518766005516 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 518766005517 Walker A/P-loop; other site 518766005518 ATP binding site [chemical binding]; other site 518766005519 Q-loop/lid; other site 518766005520 ABC transporter signature motif; other site 518766005521 Walker B; other site 518766005522 D-loop; other site 518766005523 H-loop/switch region; other site 518766005524 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 518766005525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 518766005526 dimer interface [polypeptide binding]; other site 518766005527 conserved gate region; other site 518766005528 putative PBP binding loops; other site 518766005529 ABC-ATPase subunit interface; other site 518766005530 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 518766005531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 518766005532 dimer interface [polypeptide binding]; other site 518766005533 conserved gate region; other site 518766005534 putative PBP binding loops; other site 518766005535 ABC-ATPase subunit interface; other site 518766005536 phosphate binding protein; Region: ptsS_2; TIGR02136 518766005537 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 518766005538 Zn binding site [ion binding]; other site 518766005539 Protein of unknown function (DUF461); Region: DUF461; cl01071 518766005540 FMN-binding domain; Region: FMN_bind; pfam04205 518766005541 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 518766005542 ApbE family; Region: ApbE; pfam02424 518766005543 phosphoglyceromutase; Provisional; Region: PRK05434 518766005544 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 518766005545 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 518766005546 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 518766005547 minor groove reading motif; other site 518766005548 helix-hairpin-helix signature motif; other site 518766005549 substrate binding pocket [chemical binding]; other site 518766005550 active site 518766005551 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 518766005552 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 518766005553 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 518766005554 Putative zinc ribbon domain; Region: DUF164; pfam02591 518766005555 Uncharacterized conserved protein [Function unknown]; Region: COG0327 518766005556 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 518766005557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 518766005558 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 518766005559 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 518766005560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 518766005561 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 518766005562 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 518766005563 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 518766005564 oligomeric interface; other site 518766005565 putative active site [active] 518766005566 homodimer interface [polypeptide binding]; other site 518766005567 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 518766005568 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 518766005569 Tetramer interface [polypeptide binding]; other site 518766005570 active site 518766005571 FMN-binding site [chemical binding]; other site 518766005572 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 518766005573 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 518766005574 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 518766005575 protein binding site [polypeptide binding]; other site 518766005576 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 518766005577 protein binding site [polypeptide binding]; other site 518766005578 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 518766005579 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 518766005580 putative acyl-acceptor binding pocket; other site 518766005581 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 518766005582 Interdomain contacts; other site 518766005583 Cytokine receptor motif; other site 518766005584 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 518766005585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766005586 dimer interface [polypeptide binding]; other site 518766005587 phosphorylation site [posttranslational modification] 518766005588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766005589 ATP binding site [chemical binding]; other site 518766005590 Mg2+ binding site [ion binding]; other site 518766005591 G-X-G motif; other site 518766005592 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 518766005593 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766005594 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 518766005595 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 518766005596 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 518766005597 ATP-sulfurylase; Region: ATPS; cd00517 518766005598 active site 518766005599 HXXH motif; other site 518766005600 flexible loop; other site 518766005601 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 518766005602 ligand-binding site [chemical binding]; other site 518766005603 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 518766005604 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 518766005605 TrkA-C domain; Region: TrkA_C; pfam02080 518766005606 TrkA-C domain; Region: TrkA_C; pfam02080 518766005607 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 518766005608 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 518766005609 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 518766005610 NAD binding site [chemical binding]; other site 518766005611 putative substrate binding site 2 [chemical binding]; other site 518766005612 putative substrate binding site 1 [chemical binding]; other site 518766005613 active site 518766005614 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 518766005615 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 518766005616 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 518766005617 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 518766005618 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 518766005619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766005620 active site 518766005621 phosphorylation site [posttranslational modification] 518766005622 intermolecular recognition site; other site 518766005623 dimerization interface [polypeptide binding]; other site 518766005624 LytTr DNA-binding domain; Region: LytTR; smart00850 518766005625 Histidine kinase; Region: His_kinase; pfam06580 518766005626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766005627 ATP binding site [chemical binding]; other site 518766005628 Mg2+ binding site [ion binding]; other site 518766005629 G-X-G motif; other site 518766005630 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766005631 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 518766005632 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766005633 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 518766005634 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 518766005635 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 518766005636 catalytic residue [active] 518766005637 WbqC-like protein family; Region: WbqC; pfam08889 518766005638 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 518766005639 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 518766005640 DXD motif; other site 518766005641 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 518766005642 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 518766005643 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 518766005644 oligomer interface [polypeptide binding]; other site 518766005645 metal binding site [ion binding]; metal-binding site 518766005646 metal binding site [ion binding]; metal-binding site 518766005647 Cl binding site [ion binding]; other site 518766005648 aspartate ring; other site 518766005649 basic sphincter; other site 518766005650 putative hydrophobic gate; other site 518766005651 periplasmic entrance; other site 518766005652 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 518766005653 dimer interface [polypeptide binding]; other site 518766005654 catalytic triad [active] 518766005655 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 518766005656 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 518766005657 active site 518766005658 substrate binding site [chemical binding]; other site 518766005659 cosubstrate binding site; other site 518766005660 catalytic site [active] 518766005661 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 518766005662 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 518766005663 purine monophosphate binding site [chemical binding]; other site 518766005664 dimer interface [polypeptide binding]; other site 518766005665 putative catalytic residues [active] 518766005666 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 518766005667 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 518766005668 rod shape-determining protein MreB; Provisional; Region: PRK13927 518766005669 MreB and similar proteins; Region: MreB_like; cd10225 518766005670 nucleotide binding site [chemical binding]; other site 518766005671 Mg binding site [ion binding]; other site 518766005672 putative protofilament interaction site [polypeptide binding]; other site 518766005673 RodZ interaction site [polypeptide binding]; other site 518766005674 rod shape-determining protein MreC; Provisional; Region: PRK13922 518766005675 rod shape-determining protein MreC; Region: MreC; pfam04085 518766005676 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 518766005677 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 518766005678 active site 518766005679 HslU subunit interaction site [polypeptide binding]; other site 518766005680 LabA_like proteins; Region: LabA_like; cd06167 518766005681 putative metal binding site [ion binding]; other site 518766005682 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 518766005683 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 518766005684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766005685 Walker A motif; other site 518766005686 ATP binding site [chemical binding]; other site 518766005687 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 518766005688 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 518766005689 Cupin domain; Region: Cupin_2; pfam07883 518766005690 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 518766005691 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 518766005692 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 518766005693 active site 518766005694 catalytic site [active] 518766005695 glycogen branching enzyme; Provisional; Region: PRK12313 518766005696 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 518766005697 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 518766005698 active site 518766005699 catalytic site [active] 518766005700 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 518766005701 Protein of unknown function (DUF433); Region: DUF433; pfam04255 518766005702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 518766005703 Uncharacterized conserved protein [Function unknown]; Region: COG0432 518766005704 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 518766005705 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 518766005706 active site 518766005707 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 518766005708 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 518766005709 domain interfaces; other site 518766005710 active site 518766005711 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 518766005712 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 518766005713 tRNA; other site 518766005714 putative tRNA binding site [nucleotide binding]; other site 518766005715 putative NADP binding site [chemical binding]; other site 518766005716 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 518766005717 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 518766005718 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 518766005719 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 518766005720 active site 518766005721 Ribulose bisphosphate carboxylase like proteins (RLPs) similar to R.rubrum RLP; Region: RLP_RrRLP; cd08210 518766005722 dimer interface [polypeptide binding]; other site 518766005723 active site 518766005724 catalytic residue [active] 518766005725 metal binding site [ion binding]; metal-binding site 518766005726 Bacterial Ig-like domain; Region: Big_5; pfam13205 518766005727 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766005728 oligoendopeptidase F; Region: pepF; TIGR00181 518766005729 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 518766005730 active site 518766005731 Zn binding site [ion binding]; other site 518766005732 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 518766005733 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 518766005734 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 518766005735 catalytic residues [active] 518766005736 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 518766005737 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 518766005738 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 518766005739 putative catalytic residue [active] 518766005740 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 518766005741 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 518766005742 catalytic residues [active] 518766005743 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 518766005744 active site 518766005745 Zn binding site [ion binding]; other site 518766005746 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 518766005747 putative substrate binding site 1 [chemical binding]; other site 518766005748 Na binding site 1 [ion binding]; other site 518766005749 Na2 binding site [ion binding]; other site 518766005750 putative substrate binding site 2 [chemical binding]; other site 518766005751 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 518766005752 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 518766005753 substrate binding pocket [chemical binding]; other site 518766005754 chain length determination region; other site 518766005755 substrate-Mg2+ binding site; other site 518766005756 catalytic residues [active] 518766005757 aspartate-rich region 1; other site 518766005758 active site lid residues [active] 518766005759 aspartate-rich region 2; other site 518766005760 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 518766005761 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 518766005762 Na binding site [ion binding]; other site 518766005763 putative glycosylation site [posttranslational modification]; other site 518766005764 putative glycosylation site [posttranslational modification]; other site 518766005765 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 518766005766 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 518766005767 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 518766005768 substrate binding site [chemical binding]; other site 518766005769 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 518766005770 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 518766005771 active site 518766005772 PHP Thumb interface [polypeptide binding]; other site 518766005773 metal binding site [ion binding]; metal-binding site 518766005774 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 518766005775 protein-splicing catalytic site; other site 518766005776 thioester formation/cholesterol transfer; other site 518766005777 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 518766005778 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 518766005779 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 518766005780 generic binding surface II; other site 518766005781 generic binding surface I; other site 518766005782 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 518766005783 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 518766005784 ring oligomerisation interface [polypeptide binding]; other site 518766005785 ATP/Mg binding site [chemical binding]; other site 518766005786 stacking interactions; other site 518766005787 hinge regions; other site 518766005788 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 518766005789 oligomerisation interface [polypeptide binding]; other site 518766005790 mobile loop; other site 518766005791 roof hairpin; other site 518766005792 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 518766005793 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 518766005794 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 518766005795 minor groove reading motif; other site 518766005796 helix-hairpin-helix signature motif; other site 518766005797 substrate binding pocket [chemical binding]; other site 518766005798 active site 518766005799 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 518766005800 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 518766005801 active site 518766005802 8-oxo-dGMP binding site [chemical binding]; other site 518766005803 nudix motif; other site 518766005804 metal binding site [ion binding]; metal-binding site 518766005805 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 518766005806 Surface antigen; Region: Bac_surface_Ag; pfam01103 518766005807 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 518766005808 RNA methyltransferase, RsmE family; Region: TIGR00046 518766005809 hypothetical protein; Provisional; Region: PRK02877 518766005810 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 518766005811 dimer interface [polypeptide binding]; other site 518766005812 ADP-ribose binding site [chemical binding]; other site 518766005813 active site 518766005814 nudix motif; other site 518766005815 metal binding site [ion binding]; metal-binding site 518766005816 Preprotein translocase SecG subunit; Region: SecG; cl09123 518766005817 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 518766005818 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766005819 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 518766005820 homopentamer interface [polypeptide binding]; other site 518766005821 active site 518766005822 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 518766005823 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 518766005824 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 518766005825 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 518766005826 nucleotide binding site/active site [active] 518766005827 HIT family signature motif; other site 518766005828 catalytic residue [active] 518766005829 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 518766005830 Protein of unknown function DUF72; Region: DUF72; cl00777 518766005831 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 518766005832 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 518766005833 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 518766005834 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 518766005835 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 518766005836 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 518766005837 ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Region: COG2401 518766005838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 518766005839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 518766005840 Walker A/P-loop; other site 518766005841 ATP binding site [chemical binding]; other site 518766005842 Q-loop/lid; other site 518766005843 ABC transporter signature motif; other site 518766005844 Walker B; other site 518766005845 D-loop; other site 518766005846 H-loop/switch region; other site 518766005847 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 518766005848 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 518766005849 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 518766005850 active site 518766005851 Zn binding site [ion binding]; other site 518766005852 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 518766005853 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 518766005854 substrate binding site [chemical binding]; other site 518766005855 tetramer interface [polypeptide binding]; other site 518766005856 catalytic residue [active] 518766005857 Bor protein; Region: Lambda_Bor; pfam06291 518766005858 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 518766005859 putative active site [active] 518766005860 homotetrameric interface [polypeptide binding]; other site 518766005861 metal binding site [ion binding]; metal-binding site 518766005862 Uncharacterized conserved protein [Function unknown]; Region: COG0432 518766005863 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 518766005864 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 518766005865 putative active site [active] 518766005866 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 518766005867 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 518766005868 oligomerization interface [polypeptide binding]; other site 518766005869 active site 518766005870 metal binding site [ion binding]; metal-binding site 518766005871 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 518766005872 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 518766005873 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 518766005874 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 518766005875 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 518766005876 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 518766005877 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 518766005878 Surface antigen; Region: Bac_surface_Ag; pfam01103 518766005879 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 518766005880 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 518766005881 catalytic residue [active] 518766005882 putative FPP diphosphate binding site; other site 518766005883 putative FPP binding hydrophobic cleft; other site 518766005884 dimer interface [polypeptide binding]; other site 518766005885 putative IPP diphosphate binding site; other site 518766005886 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 518766005887 RIP metalloprotease RseP; Region: TIGR00054 518766005888 active site 518766005889 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 518766005890 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 518766005891 protein binding site [polypeptide binding]; other site 518766005892 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 518766005893 putative substrate binding region [chemical binding]; other site 518766005894 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 518766005895 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 518766005896 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 518766005897 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 518766005898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 518766005899 binding surface 518766005900 TPR motif; other site 518766005901 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 518766005902 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 518766005903 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 518766005904 NADP binding site [chemical binding]; other site 518766005905 active site 518766005906 putative substrate binding site [chemical binding]; other site 518766005907 seryl-tRNA synthetase; Provisional; Region: PRK05431 518766005908 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 518766005909 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 518766005910 dimer interface [polypeptide binding]; other site 518766005911 active site 518766005912 motif 1; other site 518766005913 motif 2; other site 518766005914 motif 3; other site 518766005915 TPR repeat; Region: TPR_11; pfam13414 518766005916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005917 binding surface 518766005918 TPR motif; other site 518766005919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005920 binding surface 518766005921 TPR motif; other site 518766005922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766005923 TPR motif; other site 518766005924 binding surface 518766005925 Tetratricopeptide repeat; Region: TPR_16; pfam13432 518766005926 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 518766005927 Peptidase family M23; Region: Peptidase_M23; pfam01551 518766005928 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 518766005929 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 518766005930 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 518766005931 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 518766005932 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 518766005933 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 518766005934 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 518766005935 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 518766005936 active site 518766005937 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 518766005938 active site 518766005939 dimer interface [polypeptide binding]; other site 518766005940 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 518766005941 HDOD domain; Region: HDOD; pfam08668 518766005942 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 518766005943 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766005944 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 518766005945 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 518766005946 ligand binding site; other site 518766005947 oligomer interface; other site 518766005948 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 518766005949 dimer interface [polypeptide binding]; other site 518766005950 N-terminal domain interface [polypeptide binding]; other site 518766005951 sulfate 1 binding site; other site 518766005952 glycogen synthase; Provisional; Region: glgA; PRK00654 518766005953 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 518766005954 ADP-binding pocket [chemical binding]; other site 518766005955 homodimer interface [polypeptide binding]; other site 518766005956 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 518766005957 DNA protecting protein DprA; Region: dprA; TIGR00732 518766005958 GTPase CgtA; Reviewed; Region: obgE; PRK12299 518766005959 GTP1/OBG; Region: GTP1_OBG; pfam01018 518766005960 Obg GTPase; Region: Obg; cd01898 518766005961 G1 box; other site 518766005962 GTP/Mg2+ binding site [chemical binding]; other site 518766005963 Switch I region; other site 518766005964 G2 box; other site 518766005965 G3 box; other site 518766005966 Switch II region; other site 518766005967 G4 box; other site 518766005968 G5 box; other site 518766005969 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 518766005970 RNA/DNA hybrid binding site [nucleotide binding]; other site 518766005971 active site 518766005972 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 518766005973 Uncharacterized conserved protein [Function unknown]; Region: COG1656 518766005974 Protein of unknown function DUF82; Region: DUF82; pfam01927 518766005975 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 518766005976 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 518766005977 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 518766005978 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 518766005979 putative ligand binding site [chemical binding]; other site 518766005980 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 518766005981 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 518766005982 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 518766005983 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 518766005984 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 518766005985 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 518766005986 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 518766005987 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 518766005988 active site 518766005989 NTP binding site [chemical binding]; other site 518766005990 metal binding triad [ion binding]; metal-binding site 518766005991 antibiotic binding site [chemical binding]; other site 518766005992 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 518766005993 putative FMN binding site [chemical binding]; other site 518766005994 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 518766005995 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 518766005996 ATP-grasp domain; Region: ATP-grasp_4; cl17255 518766005997 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 518766005998 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 518766005999 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 518766006000 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 518766006001 ATP-grasp domain; Region: ATP-grasp_4; cl17255 518766006002 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 518766006003 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 518766006004 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 518766006005 catalytic site [active] 518766006006 subunit interface [polypeptide binding]; other site 518766006007 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 518766006008 Substrate-binding site [chemical binding]; other site 518766006009 Substrate specificity [chemical binding]; other site 518766006010 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 518766006011 catalytic center binding site [active] 518766006012 ATP binding site [chemical binding]; other site 518766006013 Uncharacterized conserved protein [Function unknown]; Region: COG4095 518766006014 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 518766006015 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 518766006016 NAD(P) binding site [chemical binding]; other site 518766006017 catalytic residues [active] 518766006018 Rrf2 family protein; Region: rrf2_super; TIGR00738 518766006019 Transcriptional regulator; Region: Rrf2; pfam02082 518766006020 Predicted transcriptional regulator [Transcription]; Region: COG1959 518766006021 Transcriptional regulator; Region: Rrf2; pfam02082 518766006022 Cytochrome c; Region: Cytochrom_C; pfam00034 518766006023 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 518766006024 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 518766006025 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 518766006026 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 518766006027 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 518766006028 Walker A/P-loop; other site 518766006029 ATP binding site [chemical binding]; other site 518766006030 Q-loop/lid; other site 518766006031 ABC transporter signature motif; other site 518766006032 Walker B; other site 518766006033 D-loop; other site 518766006034 H-loop/switch region; other site 518766006035 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 518766006036 active site 518766006037 NTP binding site [chemical binding]; other site 518766006038 metal binding triad [ion binding]; metal-binding site 518766006039 antibiotic binding site [chemical binding]; other site 518766006040 NosL; Region: NosL; cl01769 518766006041 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 518766006042 FOG: CBS domain [General function prediction only]; Region: COG0517 518766006043 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 518766006044 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 518766006045 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 518766006046 putative ABC transporter; Region: ycf24; CHL00085 518766006047 FeS assembly ATPase SufC; Region: sufC; TIGR01978 518766006048 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 518766006049 Walker A/P-loop; other site 518766006050 ATP binding site [chemical binding]; other site 518766006051 Q-loop/lid; other site 518766006052 ABC transporter signature motif; other site 518766006053 Walker B; other site 518766006054 D-loop; other site 518766006055 H-loop/switch region; other site 518766006056 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 518766006057 FeS assembly protein SufD; Region: sufD; TIGR01981 518766006058 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 518766006059 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 518766006060 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 518766006061 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 518766006062 catalytic residue [active] 518766006063 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 518766006064 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 518766006065 Tetratricopeptide repeat; Region: TPR_12; pfam13424 518766006066 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 518766006067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766006068 Walker A motif; other site 518766006069 ATP binding site [chemical binding]; other site 518766006070 Walker B motif; other site 518766006071 arginine finger; other site 518766006072 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 518766006073 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 518766006074 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 518766006075 active site 518766006076 metal binding site [ion binding]; metal-binding site 518766006077 Repair protein; Region: Repair_PSII; cl01535 518766006078 Double zinc ribbon; Region: DZR; pfam12773 518766006079 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 518766006080 TPR repeat; Region: TPR_11; pfam13414 518766006081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766006082 TPR motif; other site 518766006083 binding surface 518766006084 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 518766006085 Zn binding site [ion binding]; other site 518766006086 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 518766006087 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 518766006088 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 518766006089 Walker A motif; other site 518766006090 ATP binding site [chemical binding]; other site 518766006091 Walker B motif; other site 518766006092 oxidoreductase; Validated; Region: PRK05717 518766006093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 518766006094 NAD(P) binding site [chemical binding]; other site 518766006095 active site 518766006096 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 518766006097 active site 2 [active] 518766006098 active site 1 [active] 518766006099 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 518766006100 active site 518766006101 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 518766006102 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 518766006103 putative NAD(P) binding site [chemical binding]; other site 518766006104 putative active site [active] 518766006105 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 518766006106 Ion channel; Region: Ion_trans_2; pfam07885 518766006107 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 518766006108 TrkA-N domain; Region: TrkA_N; pfam02254 518766006109 TrkA-C domain; Region: TrkA_C; pfam02080 518766006110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 518766006111 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 518766006112 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 518766006113 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 518766006114 Catalytic site [active] 518766006115 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 518766006116 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 518766006117 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 518766006118 Catalytic site [active] 518766006119 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 518766006120 GTP-binding protein LepA; Provisional; Region: PRK05433 518766006121 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 518766006122 G1 box; other site 518766006123 putative GEF interaction site [polypeptide binding]; other site 518766006124 GTP/Mg2+ binding site [chemical binding]; other site 518766006125 Switch I region; other site 518766006126 G2 box; other site 518766006127 G3 box; other site 518766006128 Switch II region; other site 518766006129 G4 box; other site 518766006130 G5 box; other site 518766006131 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 518766006132 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 518766006133 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 518766006134 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 518766006135 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 518766006136 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 518766006137 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 518766006138 HIGH motif; other site 518766006139 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 518766006140 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 518766006141 active site 518766006142 KMSKS motif; other site 518766006143 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 518766006144 tRNA binding surface [nucleotide binding]; other site 518766006145 anticodon binding site; other site 518766006146 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 518766006147 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 518766006148 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 518766006149 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 518766006150 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 518766006151 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 518766006152 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 518766006153 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 518766006154 substrate binding site [chemical binding]; other site 518766006155 hexamer interface [polypeptide binding]; other site 518766006156 metal binding site [ion binding]; metal-binding site 518766006157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 518766006158 primosomal protein N' Region: priA; TIGR00595 518766006159 ATP binding site [chemical binding]; other site 518766006160 putative Mg++ binding site [ion binding]; other site 518766006161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 518766006162 ATP-binding site [chemical binding]; other site 518766006163 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 518766006164 active site 518766006165 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766006166 Preprotein translocase subunit; Region: YajC; pfam02699 518766006167 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 518766006168 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 518766006169 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 518766006170 dimerization interface [polypeptide binding]; other site 518766006171 active site 518766006172 thiamine monophosphate kinase; Provisional; Region: PRK05731 518766006173 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 518766006174 ATP binding site [chemical binding]; other site 518766006175 dimerization interface [polypeptide binding]; other site 518766006176 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 518766006177 Lipopolysaccharide-assembly; Region: LptE; pfam04390 518766006178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766006179 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 518766006180 Walker A motif; other site 518766006181 ATP binding site [chemical binding]; other site 518766006182 Walker B motif; other site 518766006183 arginine finger; other site 518766006184 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 518766006185 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 518766006186 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 518766006187 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 518766006188 FeS/SAM binding site; other site 518766006189 TRAM domain; Region: TRAM; pfam01938 518766006190 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 518766006191 Lumazine binding domain; Region: Lum_binding; pfam00677 518766006192 Lumazine binding domain; Region: Lum_binding; pfam00677 518766006193 HDOD domain; Region: HDOD; pfam08668 518766006194 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 518766006195 Zn2+ binding site [ion binding]; other site 518766006196 Mg2+ binding site [ion binding]; other site 518766006197 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 518766006198 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 518766006199 catalytic motif [active] 518766006200 Zn binding site [ion binding]; other site 518766006201 RibD C-terminal domain; Region: RibD_C; cl17279 518766006202 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 518766006203 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 518766006204 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 518766006205 PA14 domain; Region: PA14; cl08459 518766006206 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 518766006207 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 518766006208 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 518766006209 Asparagine synthase; Region: Asn_synthase; pfam00733 518766006210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 518766006211 FeS/SAM binding site; other site 518766006212 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 518766006213 UPF0489 domain; Region: UPF0489; pfam12640 518766006214 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 518766006215 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766006216 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 518766006217 DNA binding residues [nucleotide binding] 518766006218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 518766006219 putative substrate translocation pore; other site 518766006220 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 518766006221 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 518766006222 active site 518766006223 trimer interface [polypeptide binding]; other site 518766006224 allosteric site; other site 518766006225 active site lid [active] 518766006226 hexamer (dimer of trimers) interface [polypeptide binding]; other site 518766006227 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 518766006228 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 518766006229 transmembrane helices; other site 518766006230 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 518766006231 starch binding outer membrane protein SusD; Region: SusD; cd08977 518766006232 Secretin and TonB N terminus short domain; Region: STN; smart00965 518766006233 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 518766006234 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766006235 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 518766006236 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766006237 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 518766006238 FecR protein; Region: FecR; pfam04773 518766006239 aconitate hydratase; Validated; Region: PRK09277 518766006240 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 518766006241 substrate binding site [chemical binding]; other site 518766006242 ligand binding site [chemical binding]; other site 518766006243 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 518766006244 substrate binding site [chemical binding]; other site 518766006245 Helix-turn-helix domain; Region: HTH_17; pfam12728 518766006246 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 518766006247 active site 518766006248 DNA binding site [nucleotide binding] 518766006249 Int/Topo IB signature motif; other site 518766006250 allantoate amidohydrolase; Reviewed; Region: PRK09290 518766006251 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 518766006252 active site 518766006253 metal binding site [ion binding]; metal-binding site 518766006254 dimer interface [polypeptide binding]; other site 518766006255 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 518766006256 PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121 518766006257 apical/protease domain interface [polypeptide binding]; other site 518766006258 substrate binding [chemical binding]; other site 518766006259 dimer interface [polypeptide binding]; other site 518766006260 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 518766006261 Peptidase family M28; Region: Peptidase_M28; pfam04389 518766006262 metal binding site [ion binding]; metal-binding site 518766006263 Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253 518766006264 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 518766006265 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 518766006266 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 518766006267 active site 518766006268 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 518766006269 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 518766006270 DEAD/DEAH box helicase; Region: DEAD; pfam00270 518766006271 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 518766006272 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 518766006273 dimer interface [polypeptide binding]; other site 518766006274 substrate binding site [chemical binding]; other site 518766006275 ATP binding site [chemical binding]; other site 518766006276 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 518766006277 active site 518766006278 thiamine phosphate binding site [chemical binding]; other site 518766006279 pyrophosphate binding site [ion binding]; other site 518766006280 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 518766006281 ThiS interaction site; other site 518766006282 putative active site [active] 518766006283 tetramer interface [polypeptide binding]; other site 518766006284 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 518766006285 thiS-thiF/thiG interaction site; other site 518766006286 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 518766006287 hydroxyglutarate oxidase; Provisional; Region: PRK11728 518766006288 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 518766006289 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 518766006290 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 518766006291 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 518766006292 putative active site; other site 518766006293 catalytic residue [active] 518766006294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766006295 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 518766006296 Walker A motif; other site 518766006297 ATP binding site [chemical binding]; other site 518766006298 Walker B motif; other site 518766006299 arginine finger; other site 518766006300 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 518766006301 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 518766006302 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 518766006303 active site 518766006304 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 518766006305 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 518766006306 active site 518766006307 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 518766006308 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 518766006309 active site 518766006310 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 518766006311 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 518766006312 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 518766006313 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 518766006314 active site 518766006315 tetramer interface [polypeptide binding]; other site 518766006316 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 518766006317 active site 518766006318 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 518766006319 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 518766006320 Domain of unknown function DUF21; Region: DUF21; pfam01595 518766006321 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 518766006322 Transporter associated domain; Region: CorC_HlyC; smart01091 518766006323 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 518766006324 Na2 binding site [ion binding]; other site 518766006325 putative substrate binding site 1 [chemical binding]; other site 518766006326 Na binding site 1 [ion binding]; other site 518766006327 putative substrate binding site 2 [chemical binding]; other site 518766006328 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 518766006329 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 518766006330 ligand binding site [chemical binding]; other site 518766006331 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 518766006332 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 518766006333 metal binding triad; other site 518766006334 aminodeoxychorismate synthase; Provisional; Region: PRK07508 518766006335 chorismate binding enzyme; Region: Chorismate_bind; cl10555 518766006336 hypothetical protein; Provisional; Region: PRK07546 518766006337 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 518766006338 homodimer interface [polypeptide binding]; other site 518766006339 substrate-cofactor binding pocket; other site 518766006340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766006341 catalytic residue [active] 518766006342 Bacterial PH domain; Region: DUF304; pfam03703 518766006343 Bacterial PH domain; Region: DUF304; pfam03703 518766006344 Bacterial PH domain; Region: DUF304; pfam03703 518766006345 Bacterial PH domain; Region: DUF304; cl01348 518766006346 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 518766006347 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 518766006348 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 518766006349 tetramer interface [polypeptide binding]; other site 518766006350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766006351 catalytic residue [active] 518766006352 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 518766006353 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 518766006354 chaperone protein DnaJ; Provisional; Region: PRK14281 518766006355 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 518766006356 HSP70 interaction site [polypeptide binding]; other site 518766006357 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 518766006358 substrate binding site [polypeptide binding]; other site 518766006359 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 518766006360 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 518766006361 dimer interface [polypeptide binding]; other site 518766006362 GrpE; Region: GrpE; pfam01025 518766006363 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 518766006364 dimer interface [polypeptide binding]; other site 518766006365 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 518766006366 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 518766006367 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 518766006368 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 518766006369 tandem repeat interface [polypeptide binding]; other site 518766006370 oligomer interface [polypeptide binding]; other site 518766006371 active site residues [active] 518766006372 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 518766006373 tandem repeat interface [polypeptide binding]; other site 518766006374 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 518766006375 oligomer interface [polypeptide binding]; other site 518766006376 active site residues [active] 518766006377 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 518766006378 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 518766006379 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 518766006380 NAD(P) binding site [chemical binding]; other site 518766006381 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 518766006382 FAD binding domain; Region: FAD_binding_4; pfam01565 518766006383 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 518766006384 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 518766006385 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 518766006386 Beta-Casp domain; Region: Beta-Casp; pfam10996 518766006387 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 518766006388 hypothetical protein; Validated; Region: PRK09104 518766006389 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 518766006390 metal binding site [ion binding]; metal-binding site 518766006391 putative dimer interface [polypeptide binding]; other site 518766006392 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766006393 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 518766006394 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 518766006395 N-terminal plug; other site 518766006396 ligand-binding site [chemical binding]; other site 518766006397 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 518766006398 classical (c) SDRs; Region: SDR_c; cd05233 518766006399 NAD(P) binding site [chemical binding]; other site 518766006400 active site 518766006401 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 518766006402 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 518766006403 active site 518766006404 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 518766006405 catalytic triad [active] 518766006406 dimer interface [polypeptide binding]; other site 518766006407 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 518766006408 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 518766006409 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 518766006410 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 518766006411 ssDNA binding site; other site 518766006412 generic binding surface II; other site 518766006413 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 518766006414 ATP binding site [chemical binding]; other site 518766006415 putative Mg++ binding site [ion binding]; other site 518766006416 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 518766006417 nucleotide binding region [chemical binding]; other site 518766006418 ATP-binding site [chemical binding]; other site 518766006419 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 518766006420 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 518766006421 catalytic triad [active] 518766006422 HEPN domain; Region: HEPN; pfam05168 518766006423 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 518766006424 active site 518766006425 NTP binding site [chemical binding]; other site 518766006426 metal binding triad [ion binding]; metal-binding site 518766006427 antibiotic binding site [chemical binding]; other site 518766006428 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 518766006429 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 518766006430 dimerization interface [polypeptide binding]; other site 518766006431 putative DNA binding site [nucleotide binding]; other site 518766006432 putative Zn2+ binding site [ion binding]; other site 518766006433 AsnC family; Region: AsnC_trans_reg; pfam01037 518766006434 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 518766006435 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 518766006436 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 518766006437 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 518766006438 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766006439 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 518766006440 DNA binding residues [nucleotide binding] 518766006441 adenylosuccinate lyase; Provisional; Region: PRK07492 518766006442 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 518766006443 tetramer interface [polypeptide binding]; other site 518766006444 active site 518766006445 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 518766006446 NADH dehydrogenase subunit B; Validated; Region: PRK06411 518766006447 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 518766006448 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 518766006449 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 518766006450 NADH dehydrogenase subunit D; Validated; Region: PRK06075 518766006451 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 518766006452 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 518766006453 putative dimer interface [polypeptide binding]; other site 518766006454 [2Fe-2S] cluster binding site [ion binding]; other site 518766006455 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 518766006456 putative active site [active] 518766006457 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 518766006458 putative active site [active] 518766006459 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 518766006460 putative active site [active] 518766006461 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 518766006462 SLBB domain; Region: SLBB; pfam10531 518766006463 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 518766006464 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 518766006465 catalytic loop [active] 518766006466 iron binding site [ion binding]; other site 518766006467 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 518766006468 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 518766006469 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 518766006470 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 518766006471 malate synthase A; Region: malate_syn_A; TIGR01344 518766006472 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 518766006473 active site 518766006474 Transcriptional regulator [Transcription]; Region: IclR; COG1414 518766006475 Bacterial transcriptional regulator; Region: IclR; pfam01614 518766006476 purine nucleoside phosphorylase; Provisional; Region: PRK08202 518766006477 DivIVA protein; Region: DivIVA; pfam05103 518766006478 DivIVA domain; Region: DivI1A_domain; TIGR03544 518766006479 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 518766006480 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 518766006481 catalytic residue [active] 518766006482 spermidine synthase; Provisional; Region: PRK00811 518766006483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766006484 S-adenosylmethionine binding site [chemical binding]; other site 518766006485 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 518766006486 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 518766006487 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 518766006488 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 518766006489 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 518766006490 ligand binding site [chemical binding]; other site 518766006491 homodimer interface [polypeptide binding]; other site 518766006492 NAD(P) binding site [chemical binding]; other site 518766006493 trimer interface B [polypeptide binding]; other site 518766006494 trimer interface A [polypeptide binding]; other site 518766006495 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 518766006496 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 518766006497 catalytic residue [active] 518766006498 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 518766006499 putative ligand binding site [chemical binding]; other site 518766006500 putative NAD binding site [chemical binding]; other site 518766006501 putative catalytic site [active] 518766006502 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 518766006503 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 518766006504 Uncharacterized conserved protein [Function unknown]; Region: COG4198 518766006505 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 518766006506 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 518766006507 dimerization interface [polypeptide binding]; other site 518766006508 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 518766006509 dimerization interface [polypeptide binding]; other site 518766006510 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 518766006511 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 518766006512 dimer interface [polypeptide binding]; other site 518766006513 putative CheW interface [polypeptide binding]; other site 518766006514 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 518766006515 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 518766006516 active site 518766006517 recombinase A; Provisional; Region: recA; PRK09354 518766006518 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 518766006519 hexamer interface [polypeptide binding]; other site 518766006520 Walker A motif; other site 518766006521 ATP binding site [chemical binding]; other site 518766006522 Walker B motif; other site 518766006523 competence damage-inducible protein A; Provisional; Region: PRK00549 518766006524 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 518766006525 putative MPT binding site; other site 518766006526 Competence-damaged protein; Region: CinA; pfam02464 518766006527 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 518766006528 active site 518766006529 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 518766006530 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 518766006531 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 518766006532 nucleotide binding site [chemical binding]; other site 518766006533 NEF interaction site [polypeptide binding]; other site 518766006534 SBD interface [polypeptide binding]; other site 518766006535 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 518766006536 active site 518766006537 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 518766006538 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 518766006539 GAF domain; Region: GAF; cl17456 518766006540 Histidine kinase; Region: His_kinase; pfam06580 518766006541 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 518766006542 ATP binding site [chemical binding]; other site 518766006543 Mg2+ binding site [ion binding]; other site 518766006544 G-X-G motif; other site 518766006545 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 518766006546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766006547 active site 518766006548 phosphorylation site [posttranslational modification] 518766006549 intermolecular recognition site; other site 518766006550 dimerization interface [polypeptide binding]; other site 518766006551 LytTr DNA-binding domain; Region: LytTR; smart00850 518766006552 Stage II sporulation protein; Region: SpoIID; pfam08486 518766006553 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 518766006554 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 518766006555 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 518766006556 N-terminal plug; other site 518766006557 ligand-binding site [chemical binding]; other site 518766006558 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 518766006559 nudix motif; other site 518766006560 isocitrate dehydrogenase; Validated; Region: PRK09222 518766006561 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 518766006562 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 518766006563 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 518766006564 active site 518766006565 catalytic site [active] 518766006566 metal binding site [ion binding]; metal-binding site 518766006567 DNA gyrase subunit A; Validated; Region: PRK05560 518766006568 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 518766006569 CAP-like domain; other site 518766006570 active site 518766006571 primary dimer interface [polypeptide binding]; other site 518766006572 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 518766006573 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 518766006574 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 518766006575 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 518766006576 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 518766006577 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 518766006578 L-lysine aminotransferase; Provisional; Region: PRK08297 518766006579 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 518766006580 inhibitor-cofactor binding pocket; inhibition site 518766006581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766006582 catalytic residue [active] 518766006583 lipoyl synthase; Provisional; Region: PRK05481 518766006584 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 518766006585 FeS/SAM binding site; other site 518766006586 SCP-2 sterol transfer family; Region: SCP2; pfam02036 518766006587 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 518766006588 CoA-transferase family III; Region: CoA_transf_3; pfam02515 518766006589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 518766006590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 518766006591 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 518766006592 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766006593 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766006594 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766006595 4-coumarate--CoA ligase; Region: PLN02246 518766006596 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 518766006597 acyl-activating enzyme (AAE) consensus motif; other site 518766006598 active site 518766006599 putative CoA binding site [chemical binding]; other site 518766006600 AMP binding site [chemical binding]; other site 518766006601 short chain dehydrogenase; Provisional; Region: PRK08278 518766006602 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 518766006603 NAD(P) binding site [chemical binding]; other site 518766006604 homodimer interface [polypeptide binding]; other site 518766006605 active site 518766006606 enoyl-CoA hydratase; Provisional; Region: PRK06688 518766006607 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 518766006608 substrate binding site [chemical binding]; other site 518766006609 oxyanion hole (OAH) forming residues; other site 518766006610 trimer interface [polypeptide binding]; other site 518766006611 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 518766006612 Amidase; Region: Amidase; pfam01425 518766006613 short chain dehydrogenase; Provisional; Region: PRK07035 518766006614 classical (c) SDRs; Region: SDR_c; cd05233 518766006615 NAD(P) binding site [chemical binding]; other site 518766006616 active site 518766006617 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 518766006618 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 518766006619 active site 518766006620 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 518766006621 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 518766006622 active site 518766006623 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 518766006624 Phosphotransferase enzyme family; Region: APH; pfam01636 518766006625 putative active site [active] 518766006626 putative substrate binding site [chemical binding]; other site 518766006627 ATP binding site [chemical binding]; other site 518766006628 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 518766006629 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766006630 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 518766006631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 518766006632 FeS/SAM binding site; other site 518766006633 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 518766006634 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 518766006635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 518766006636 DNA-binding site [nucleotide binding]; DNA binding site 518766006637 UTRA domain; Region: UTRA; pfam07702 518766006638 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 518766006639 active site 518766006640 multimer interface [polypeptide binding]; other site 518766006641 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 518766006642 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 518766006643 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 518766006644 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 518766006645 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 518766006646 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 518766006647 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 518766006648 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 518766006649 putative catalytic residues [active] 518766006650 nucleotide binding site [chemical binding]; other site 518766006651 aspartate binding site [chemical binding]; other site 518766006652 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 518766006653 dimer interface [polypeptide binding]; other site 518766006654 putative threonine allosteric regulatory site; other site 518766006655 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 518766006656 putative threonine allosteric regulatory site; other site 518766006657 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 518766006658 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 518766006659 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 518766006660 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 518766006661 dimer interface [polypeptide binding]; other site 518766006662 Citrate synthase; Region: Citrate_synt; pfam00285 518766006663 active site 518766006664 citrylCoA binding site [chemical binding]; other site 518766006665 NADH binding [chemical binding]; other site 518766006666 cationic pore residues; other site 518766006667 oxalacetate/citrate binding site [chemical binding]; other site 518766006668 coenzyme A binding site [chemical binding]; other site 518766006669 catalytic triad [active] 518766006670 Putative zinc-finger; Region: zf-HC2; pfam13490 518766006671 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766006672 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 518766006673 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 518766006674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766006675 active site 518766006676 phosphorylation site [posttranslational modification] 518766006677 intermolecular recognition site; other site 518766006678 dimerization interface [polypeptide binding]; other site 518766006679 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 518766006680 DNA binding residues [nucleotide binding] 518766006681 dimerization interface [polypeptide binding]; other site 518766006682 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 518766006683 GAF domain; Region: GAF; pfam01590 518766006684 PAS domain S-box; Region: sensory_box; TIGR00229 518766006685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766006686 putative active site [active] 518766006687 heme pocket [chemical binding]; other site 518766006688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 518766006689 Histidine kinase; Region: HisKA_3; pfam07730 518766006690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766006691 ATP binding site [chemical binding]; other site 518766006692 Mg2+ binding site [ion binding]; other site 518766006693 G-X-G motif; other site 518766006694 TPR repeat; Region: TPR_11; pfam13414 518766006695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766006696 binding surface 518766006697 TPR motif; other site 518766006698 Tetratricopeptide repeat; Region: TPR_16; pfam13432 518766006699 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 518766006700 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766006701 Methyltransferase domain; Region: Methyltransf_23; pfam13489 518766006702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766006703 S-adenosylmethionine binding site [chemical binding]; other site 518766006704 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 518766006705 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 518766006706 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 518766006707 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 518766006708 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 518766006709 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 518766006710 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 518766006711 SAF-like; Region: SAF_2; pfam13144 518766006712 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 518766006713 Flagellar L-ring protein; Region: FlgH; cl17277 518766006714 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 518766006715 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 518766006716 Rod binding protein; Region: Rod-binding; cl01626 518766006717 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 518766006718 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 518766006719 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 518766006720 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 518766006721 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 518766006722 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 518766006723 HDOD domain; Region: HDOD; pfam08668 518766006724 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 518766006725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766006726 Response regulator receiver domain; Region: Response_reg; pfam00072 518766006727 active site 518766006728 phosphorylation site [posttranslational modification] 518766006729 intermolecular recognition site; other site 518766006730 dimerization interface [polypeptide binding]; other site 518766006731 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 518766006732 Na binding site [ion binding]; other site 518766006733 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 518766006734 oligomerisation interface [polypeptide binding]; other site 518766006735 mobile loop; other site 518766006736 roof hairpin; other site 518766006737 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 518766006738 active site 518766006739 substrate binding site [chemical binding]; other site 518766006740 ATP binding site [chemical binding]; other site 518766006741 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 518766006742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 518766006743 non-specific DNA binding site [nucleotide binding]; other site 518766006744 salt bridge; other site 518766006745 sequence-specific DNA binding site [nucleotide binding]; other site 518766006746 Domain of unknown function (DUF955); Region: DUF955; pfam06114 518766006747 isocitrate lyase; Provisional; Region: PRK15063 518766006748 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 518766006749 tetramer interface [polypeptide binding]; other site 518766006750 active site 518766006751 Mg2+/Mn2+ binding site [ion binding]; other site 518766006752 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 518766006753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 518766006754 TPR motif; other site 518766006755 binding surface 518766006756 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 518766006757 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 518766006758 DNA polymerase III subunit delta'; Validated; Region: PRK05564 518766006759 DNA polymerase III subunit delta'; Validated; Region: PRK08485 518766006760 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 518766006761 elongation factor G; Reviewed; Region: PRK12740 518766006762 G1 box; other site 518766006763 putative GEF interaction site [polypeptide binding]; other site 518766006764 GTP/Mg2+ binding site [chemical binding]; other site 518766006765 Switch I region; other site 518766006766 G2 box; other site 518766006767 G3 box; other site 518766006768 Switch II region; other site 518766006769 G4 box; other site 518766006770 G5 box; other site 518766006771 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 518766006772 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 518766006773 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 518766006774 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 518766006775 Glycoprotease family; Region: Peptidase_M22; pfam00814 518766006776 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 518766006777 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 518766006778 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 518766006779 cell surface protein SprA; Region: surface_SprA; TIGR04189 518766006780 Motility related/secretion protein; Region: SprA_N; pfam14349 518766006781 Motility related/secretion protein; Region: SprA_N; pfam14349 518766006782 Motility related/secretion protein; Region: SprA_N; pfam14349 518766006783 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 518766006784 Protein of unknown function (DUF423); Region: DUF423; pfam04241 518766006785 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 518766006786 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 518766006787 UGMP family protein; Validated; Region: PRK09604 518766006788 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 518766006789 Chorismate mutase type II; Region: CM_2; smart00830 518766006790 YceG-like family; Region: YceG; pfam02618 518766006791 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 518766006792 dimerization interface [polypeptide binding]; other site 518766006793 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 518766006794 prolyl-tRNA synthetase; Provisional; Region: PRK08661 518766006795 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 518766006796 dimer interface [polypeptide binding]; other site 518766006797 motif 1; other site 518766006798 active site 518766006799 motif 2; other site 518766006800 motif 3; other site 518766006801 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 518766006802 anticodon binding site; other site 518766006803 zinc-binding site [ion binding]; other site 518766006804 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766006805 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 518766006806 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766006807 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 518766006808 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 518766006809 active site 518766006810 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 518766006811 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 518766006812 substrate binding site [chemical binding]; other site 518766006813 ATP binding site [chemical binding]; other site 518766006814 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 518766006815 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 518766006816 active site 518766006817 intersubunit interface [polypeptide binding]; other site 518766006818 catalytic residue [active] 518766006819 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 518766006820 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 518766006821 metal binding site [ion binding]; metal-binding site 518766006822 substrate binding pocket [chemical binding]; other site 518766006823 DctM-like transporters; Region: DctM; pfam06808 518766006824 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 518766006825 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 518766006826 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 518766006827 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 518766006828 Uncharacterized conserved protein [Function unknown]; Region: COG3189 518766006829 Cupin domain; Region: Cupin_2; cl17218 518766006830 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 518766006831 4Fe-4S binding domain; Region: Fer4; pfam00037 518766006832 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 518766006833 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 518766006834 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 518766006835 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 518766006836 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 518766006837 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 518766006838 Hemerythrin-like domain; Region: Hr-like; cd12108 518766006839 Fe binding site [ion binding]; other site 518766006840 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 518766006841 Predicted transcriptional regulator [Transcription]; Region: COG2345 518766006842 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 518766006843 nucleoside/Zn binding site; other site 518766006844 dimer interface [polypeptide binding]; other site 518766006845 catalytic motif [active] 518766006846 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 518766006847 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 518766006848 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 518766006849 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 518766006850 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 518766006851 putative active site [active] 518766006852 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 518766006853 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 518766006854 TPR repeat; Region: TPR_11; pfam13414 518766006855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766006856 binding surface 518766006857 TPR motif; other site 518766006858 KduI/IolB family; Region: KduI; cl01508 518766006859 glucuronate isomerase; Reviewed; Region: PRK02925 518766006860 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 518766006861 Rhomboid family; Region: Rhomboid; pfam01694 518766006862 Predicted membrane protein [Function unknown]; Region: COG3174 518766006863 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 518766006864 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 518766006865 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 518766006866 putative active site [active] 518766006867 catalytic triad [active] 518766006868 Uncharacterized conserved protein [Function unknown]; Region: COG2353 518766006869 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 518766006870 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 518766006871 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 518766006872 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 518766006873 transcription termination factor Rho; Provisional; Region: PRK12608 518766006874 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 518766006875 RNA binding site [nucleotide binding]; other site 518766006876 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 518766006877 multimer interface [polypeptide binding]; other site 518766006878 Walker A motif; other site 518766006879 ATP binding site [chemical binding]; other site 518766006880 Walker B motif; other site 518766006881 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766006882 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 518766006883 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766006884 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766006885 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766006886 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 518766006887 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766006888 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766006889 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 518766006890 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 518766006891 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 518766006892 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 518766006893 Domain interface; other site 518766006894 Peptide binding site; other site 518766006895 Active site tetrad [active] 518766006896 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 518766006897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 518766006898 motif II; other site 518766006899 NAD synthetase; Provisional; Region: PRK13981 518766006900 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 518766006901 multimer interface [polypeptide binding]; other site 518766006902 active site 518766006903 catalytic triad [active] 518766006904 protein interface 1 [polypeptide binding]; other site 518766006905 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 518766006906 homodimer interface [polypeptide binding]; other site 518766006907 NAD binding pocket [chemical binding]; other site 518766006908 ATP binding pocket [chemical binding]; other site 518766006909 Mg binding site [ion binding]; other site 518766006910 active-site loop [active] 518766006911 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 518766006912 RuvA N terminal domain; Region: RuvA_N; pfam01330 518766006913 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 518766006914 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 518766006915 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 518766006916 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 518766006917 dimerization interface [polypeptide binding]; other site 518766006918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766006919 dimer interface [polypeptide binding]; other site 518766006920 phosphorylation site [posttranslational modification] 518766006921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766006922 ATP binding site [chemical binding]; other site 518766006923 Mg2+ binding site [ion binding]; other site 518766006924 G-X-G motif; other site 518766006925 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 518766006926 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766006927 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766006928 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 518766006929 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 518766006930 FecR protein; Region: FecR; pfam04773 518766006931 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06406 518766006932 Right handed beta helix region; Region: Beta_helix; pfam13229 518766006933 Right handed beta helix region; Region: Beta_helix; pfam13229 518766006934 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766006935 Methyltransferase domain; Region: Methyltransf_23; pfam13489 518766006936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766006937 S-adenosylmethionine binding site [chemical binding]; other site 518766006938 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 518766006939 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 518766006940 metal ion-dependent adhesion site (MIDAS); other site 518766006941 NAD-dependent deacetylase; Provisional; Region: PRK00481 518766006942 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 518766006943 NAD+ binding site [chemical binding]; other site 518766006944 substrate binding site [chemical binding]; other site 518766006945 Zn binding site [ion binding]; other site 518766006946 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 518766006947 Domain of unknown function DUF59; Region: DUF59; pfam01883 518766006948 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 518766006949 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 518766006950 Walker A motif; other site 518766006951 exopolyphosphatase; Region: exo_poly_only; TIGR03706 518766006952 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 518766006953 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 518766006954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766006955 S-adenosylmethionine binding site [chemical binding]; other site 518766006956 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 518766006957 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 518766006958 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 518766006959 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 518766006960 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 518766006961 anti sigma factor interaction site; other site 518766006962 regulatory phosphorylation site [posttranslational modification]; other site 518766006963 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 518766006964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766006965 ATP binding site [chemical binding]; other site 518766006966 Mg2+ binding site [ion binding]; other site 518766006967 G-X-G motif; other site 518766006968 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 518766006969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766006970 S-adenosylmethionine binding site [chemical binding]; other site 518766006971 6-phosphofructokinase; Provisional; Region: PRK03202 518766006972 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 518766006973 active site 518766006974 ADP/pyrophosphate binding site [chemical binding]; other site 518766006975 dimerization interface [polypeptide binding]; other site 518766006976 allosteric effector site; other site 518766006977 fructose-1,6-bisphosphate binding site; other site 518766006978 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 518766006979 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 518766006980 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 518766006981 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766006982 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 518766006983 DNA binding residues [nucleotide binding] 518766006984 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 518766006985 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 518766006986 homodimer interface [polypeptide binding]; other site 518766006987 substrate-cofactor binding pocket; other site 518766006988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766006989 catalytic residue [active] 518766006990 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 518766006991 DNA repair protein RadA; Provisional; Region: PRK11823 518766006992 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 518766006993 Walker A motif/ATP binding site; other site 518766006994 ATP binding site [chemical binding]; other site 518766006995 Walker B motif; other site 518766006996 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 518766006997 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 518766006998 Permease; Region: Permease; pfam02405 518766006999 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 518766007000 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 518766007001 Walker A/P-loop; other site 518766007002 ATP binding site [chemical binding]; other site 518766007003 Q-loop/lid; other site 518766007004 ABC transporter signature motif; other site 518766007005 Walker B; other site 518766007006 D-loop; other site 518766007007 H-loop/switch region; other site 518766007008 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 518766007009 mce related protein; Region: MCE; pfam02470 518766007010 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 518766007011 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 518766007012 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 518766007013 AAA domain; Region: AAA_18; pfam13238 518766007014 Substrate-binding site [chemical binding]; other site 518766007015 Substrate specificity [chemical binding]; other site 518766007016 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 518766007017 trimer interface [polypeptide binding]; other site 518766007018 active site 518766007019 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 518766007020 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 518766007021 dimer interface [polypeptide binding]; other site 518766007022 anticodon binding site; other site 518766007023 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 518766007024 homodimer interface [polypeptide binding]; other site 518766007025 motif 1; other site 518766007026 active site 518766007027 motif 2; other site 518766007028 GAD domain; Region: GAD; pfam02938 518766007029 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 518766007030 motif 3; other site 518766007031 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 518766007032 spermidine synthase; Provisional; Region: PRK00811 518766007033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 518766007034 S-adenosylmethionine binding site [chemical binding]; other site 518766007035 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 518766007036 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 518766007037 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 518766007038 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 518766007039 Ubiquitin-like proteins; Region: UBQ; cl00155 518766007040 charged pocket; other site 518766007041 hydrophobic patch; other site 518766007042 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 518766007043 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 518766007044 Active Sites [active] 518766007045 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 518766007046 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 518766007047 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 518766007048 Response regulator receiver domain; Region: Response_reg; pfam00072 518766007049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766007050 active site 518766007051 phosphorylation site [posttranslational modification] 518766007052 intermolecular recognition site; other site 518766007053 dimerization interface [polypeptide binding]; other site 518766007054 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 518766007055 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 518766007056 metal binding site [ion binding]; metal-binding site 518766007057 active site 518766007058 I-site; other site 518766007059 Response regulator receiver domain; Region: Response_reg; pfam00072 518766007060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766007061 active site 518766007062 phosphorylation site [posttranslational modification] 518766007063 intermolecular recognition site; other site 518766007064 dimerization interface [polypeptide binding]; other site 518766007065 HEAT repeats; Region: HEAT_2; pfam13646 518766007066 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 518766007067 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 518766007068 DXD motif; other site 518766007069 hypothetical protein; Provisional; Region: PRK13665 518766007070 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 518766007071 trimer interface [polypeptide binding]; other site 518766007072 dimer interface [polypeptide binding]; other site 518766007073 putative active site [active] 518766007074 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 518766007075 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 518766007076 active site 518766007077 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 518766007078 putative active site [active] 518766007079 dimerization interface [polypeptide binding]; other site 518766007080 putative tRNAtyr binding site [nucleotide binding]; other site 518766007081 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 518766007082 active site 518766007083 dimerization interface [polypeptide binding]; other site 518766007084 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 518766007085 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 518766007086 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 518766007087 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 518766007088 TPP-binding site [chemical binding]; other site 518766007089 Uncharacterized conserved protein (DUF2361); Region: DUF2361; pfam10153 518766007090 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 518766007091 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 518766007092 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 518766007093 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 518766007094 P loop; other site 518766007095 GTP binding site [chemical binding]; other site 518766007096 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 518766007097 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 518766007098 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 518766007099 putative trimer interface [polypeptide binding]; other site 518766007100 putative CoA binding site [chemical binding]; other site 518766007101 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 518766007102 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 518766007103 metal ion-dependent adhesion site (MIDAS); other site 518766007104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766007105 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 518766007106 Walker A motif; other site 518766007107 ATP binding site [chemical binding]; other site 518766007108 Walker B motif; other site 518766007109 arginine finger; other site 518766007110 Predicted transcriptional regulators [Transcription]; Region: COG1733 518766007111 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 518766007112 dimerization interface [polypeptide binding]; other site 518766007113 putative DNA binding site [nucleotide binding]; other site 518766007114 putative Zn2+ binding site [ion binding]; other site 518766007115 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 518766007116 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 518766007117 NADP binding site [chemical binding]; other site 518766007118 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 518766007119 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 518766007120 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 518766007121 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 518766007122 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 518766007123 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 518766007124 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 518766007125 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 518766007126 putative metal binding site [ion binding]; other site 518766007127 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 518766007128 active site 518766007129 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 518766007130 Na binding site [ion binding]; other site 518766007131 Isochorismatase family; Region: Isochorismatase; pfam00857 518766007132 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 518766007133 catalytic triad [active] 518766007134 conserved cis-peptide bond; other site 518766007135 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 518766007136 active site 518766007137 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 518766007138 dimer interface [polypeptide binding]; other site 518766007139 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 518766007140 Ligand Binding Site [chemical binding]; other site 518766007141 Molecular Tunnel; other site 518766007142 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 518766007143 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 518766007144 putative transporter; Provisional; Region: PRK10484 518766007145 Na binding site [ion binding]; other site 518766007146 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 518766007147 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 518766007148 NADP binding site [chemical binding]; other site 518766007149 homodimer interface [polypeptide binding]; other site 518766007150 active site 518766007151 Right handed beta helix region; Region: Beta_helix; pfam13229 518766007152 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766007153 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 518766007154 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 518766007155 Pectate lyase; Region: Pec_lyase_C; cl01593 518766007156 Fn3 associated; Region: Fn3_assoc; pfam13287 518766007157 PA14 domain; Region: PA14; cl08459 518766007158 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766007159 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766007160 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766007161 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766007162 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 518766007163 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766007164 hypothetical protein; Validated; Region: PRK00110 518766007165 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 518766007166 active site 518766007167 putative DNA-binding cleft [nucleotide binding]; other site 518766007168 dimer interface [polypeptide binding]; other site 518766007169 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 518766007170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 518766007171 Walker A/P-loop; other site 518766007172 ATP binding site [chemical binding]; other site 518766007173 Q-loop/lid; other site 518766007174 ABC transporter signature motif; other site 518766007175 Walker B; other site 518766007176 D-loop; other site 518766007177 H-loop/switch region; other site 518766007178 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 518766007179 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 518766007180 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 518766007181 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 518766007182 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 518766007183 structural tetrad; other site 518766007184 Surface antigen; Region: Bac_surface_Ag; pfam01103 518766007185 trigger factor; Region: tig; TIGR00115 518766007186 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 518766007187 Clp protease; Region: CLP_protease; pfam00574 518766007188 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 518766007189 oligomer interface [polypeptide binding]; other site 518766007190 active site residues [active] 518766007191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766007192 active site 518766007193 phosphorylation site [posttranslational modification] 518766007194 intermolecular recognition site; other site 518766007195 dimerization interface [polypeptide binding]; other site 518766007196 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766007197 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 518766007198 putative active site [active] 518766007199 heme pocket [chemical binding]; other site 518766007200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766007201 dimer interface [polypeptide binding]; other site 518766007202 phosphorylation site [posttranslational modification] 518766007203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766007204 ATP binding site [chemical binding]; other site 518766007205 Mg2+ binding site [ion binding]; other site 518766007206 G-X-G motif; other site 518766007207 Response regulator receiver domain; Region: Response_reg; pfam00072 518766007208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766007209 active site 518766007210 phosphorylation site [posttranslational modification] 518766007211 intermolecular recognition site; other site 518766007212 dimerization interface [polypeptide binding]; other site 518766007213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766007214 Response regulator receiver domain; Region: Response_reg; pfam00072 518766007215 active site 518766007216 phosphorylation site [posttranslational modification] 518766007217 intermolecular recognition site; other site 518766007218 dimerization interface [polypeptide binding]; other site 518766007219 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766007220 PAS domain; Region: PAS_9; pfam13426 518766007221 putative active site [active] 518766007222 heme pocket [chemical binding]; other site 518766007223 PAS fold; Region: PAS_4; pfam08448 518766007224 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 518766007225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766007226 putative active site [active] 518766007227 heme pocket [chemical binding]; other site 518766007228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766007229 dimer interface [polypeptide binding]; other site 518766007230 phosphorylation site [posttranslational modification] 518766007231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766007232 ATP binding site [chemical binding]; other site 518766007233 Mg2+ binding site [ion binding]; other site 518766007234 G-X-G motif; other site 518766007235 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 518766007236 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 518766007237 E3 interaction surface; other site 518766007238 lipoyl attachment site [posttranslational modification]; other site 518766007239 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 518766007240 E3 interaction surface; other site 518766007241 lipoyl attachment site [posttranslational modification]; other site 518766007242 e3 binding domain; Region: E3_binding; pfam02817 518766007243 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 518766007244 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 518766007245 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 518766007246 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 518766007247 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 518766007248 putative active site [active] 518766007249 catalytic residue [active] 518766007250 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 518766007251 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 518766007252 5S rRNA interface [nucleotide binding]; other site 518766007253 CTC domain interface [polypeptide binding]; other site 518766007254 L16 interface [polypeptide binding]; other site 518766007255 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 518766007256 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 518766007257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 518766007258 active site 518766007259 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 518766007260 homodimer interface [polypeptide binding]; other site 518766007261 homotetramer interface [polypeptide binding]; other site 518766007262 active site pocket [active] 518766007263 cleavage site 518766007264 aspartate racemase; Region: asp_race; TIGR00035 518766007265 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 518766007266 HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3 518766007267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 518766007268 active site 518766007269 motif I; other site 518766007270 motif II; other site 518766007271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 518766007272 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 518766007273 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 518766007274 active site 518766007275 putative lithium-binding site [ion binding]; other site 518766007276 substrate binding site [chemical binding]; other site 518766007277 PIN domain; Region: PIN_3; pfam13470 518766007278 BNR repeat-like domain; Region: BNR_2; pfam13088 518766007279 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 518766007280 Asp-box motif; other site 518766007281 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 518766007282 CcmE; Region: CcmE; cl00994 518766007283 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 518766007284 CcmB protein; Region: CcmB; cl17444 518766007285 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 518766007286 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 518766007287 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766007288 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 518766007289 Cytochrome c; Region: Cytochrom_C; pfam00034 518766007290 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 518766007291 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 518766007292 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 518766007293 G1 box; other site 518766007294 putative GEF interaction site [polypeptide binding]; other site 518766007295 GTP/Mg2+ binding site [chemical binding]; other site 518766007296 Switch I region; other site 518766007297 G2 box; other site 518766007298 G3 box; other site 518766007299 Switch II region; other site 518766007300 G4 box; other site 518766007301 G5 box; other site 518766007302 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 518766007303 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 518766007304 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 518766007305 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 518766007306 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 518766007307 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 518766007308 substrate binding pocket [chemical binding]; other site 518766007309 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 518766007310 B12 binding site [chemical binding]; other site 518766007311 cobalt ligand [ion binding]; other site 518766007312 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 518766007313 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 518766007314 GAF domain; Region: GAF; pfam01590 518766007315 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 518766007316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766007317 putative active site [active] 518766007318 heme pocket [chemical binding]; other site 518766007319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766007320 dimer interface [polypeptide binding]; other site 518766007321 phosphorylation site [posttranslational modification] 518766007322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766007323 ATP binding site [chemical binding]; other site 518766007324 Mg2+ binding site [ion binding]; other site 518766007325 G-X-G motif; other site 518766007326 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 518766007327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766007328 active site 518766007329 phosphorylation site [posttranslational modification] 518766007330 intermolecular recognition site; other site 518766007331 dimerization interface [polypeptide binding]; other site 518766007332 HDOD domain; Region: HDOD; pfam08668 518766007333 Response regulator receiver domain; Region: Response_reg; pfam00072 518766007334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766007335 active site 518766007336 phosphorylation site [posttranslational modification] 518766007337 intermolecular recognition site; other site 518766007338 dimerization interface [polypeptide binding]; other site 518766007339 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 518766007340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766007341 active site 518766007342 phosphorylation site [posttranslational modification] 518766007343 intermolecular recognition site; other site 518766007344 dimerization interface [polypeptide binding]; other site 518766007345 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 518766007346 DNA binding residues [nucleotide binding] 518766007347 dimerization interface [polypeptide binding]; other site 518766007348 PAS domain S-box; Region: sensory_box; TIGR00229 518766007349 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766007350 putative active site [active] 518766007351 heme pocket [chemical binding]; other site 518766007352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 518766007353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766007354 ATP binding site [chemical binding]; other site 518766007355 Mg2+ binding site [ion binding]; other site 518766007356 G-X-G motif; other site 518766007357 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 518766007358 dimerization interface [polypeptide binding]; other site 518766007359 putative active cleft [active] 518766007360 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 518766007361 active site 518766007362 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 518766007363 Na binding site [ion binding]; other site 518766007364 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 518766007365 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 518766007366 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766007367 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766007368 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 518766007369 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766007370 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766007371 MarR family; Region: MarR_2; pfam12802 518766007372 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 518766007373 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 518766007374 nucleotide binding site [chemical binding]; other site 518766007375 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 518766007376 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 518766007377 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 518766007378 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 518766007379 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 518766007380 acyl-activating enzyme (AAE) consensus motif; other site 518766007381 acyl-activating enzyme (AAE) consensus motif; other site 518766007382 putative AMP binding site [chemical binding]; other site 518766007383 putative active site [active] 518766007384 putative CoA binding site [chemical binding]; other site 518766007385 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 518766007386 Na binding site [ion binding]; other site 518766007387 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 518766007388 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 518766007389 dimer interface [polypeptide binding]; other site 518766007390 active site 518766007391 CoA binding pocket [chemical binding]; other site 518766007392 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 518766007393 homotetramer interface [polypeptide binding]; other site 518766007394 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 518766007395 NAD(P) binding site [chemical binding]; other site 518766007396 homodimer interface [polypeptide binding]; other site 518766007397 active site 518766007398 Predicted transcriptional regulators [Transcription]; Region: COG1510 518766007399 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 518766007400 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 518766007401 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 518766007402 DNA binding residues [nucleotide binding] 518766007403 dimer interface [polypeptide binding]; other site 518766007404 metal binding site [ion binding]; metal-binding site 518766007405 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 518766007406 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 518766007407 metal-binding site [ion binding] 518766007408 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 518766007409 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 518766007410 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 518766007411 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 518766007412 metal-binding site [ion binding] 518766007413 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 518766007414 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 518766007415 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 518766007416 HlyD family secretion protein; Region: HlyD_3; pfam13437 518766007417 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 518766007418 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 518766007419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 518766007420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 518766007421 putative substrate translocation pore; other site 518766007422 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 518766007423 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 518766007424 dimerization interface [polypeptide binding]; other site 518766007425 putative DNA binding site [nucleotide binding]; other site 518766007426 putative Zn2+ binding site [ion binding]; other site 518766007427 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 518766007428 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 518766007429 metal-binding site [ion binding] 518766007430 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 518766007431 Soluble P-type ATPase [General function prediction only]; Region: COG4087 518766007432 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 518766007433 Clp amino terminal domain; Region: Clp_N; pfam02861 518766007434 Clp amino terminal domain; Region: Clp_N; pfam02861 518766007435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766007436 Walker A motif; other site 518766007437 ATP binding site [chemical binding]; other site 518766007438 Walker B motif; other site 518766007439 arginine finger; other site 518766007440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766007441 Walker A motif; other site 518766007442 ATP binding site [chemical binding]; other site 518766007443 Walker B motif; other site 518766007444 arginine finger; other site 518766007445 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 518766007446 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 518766007447 Chromate transporter; Region: Chromate_transp; pfam02417 518766007448 Abhydrolase family; Region: Abhydrolase_7; pfam12715 518766007449 Dienelactone hydrolase family; Region: DLH; pfam01738 518766007450 putative pectinesterase; Region: PLN02432; cl01911 518766007451 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 518766007452 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 518766007453 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766007454 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 518766007455 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766007456 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766007457 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 518766007458 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 518766007459 GTP binding site; other site 518766007460 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 518766007461 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 518766007462 glycyl-tRNA synthetase; Provisional; Region: PRK04173 518766007463 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 518766007464 motif 1; other site 518766007465 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 518766007466 active site 518766007467 motif 2; other site 518766007468 motif 3; other site 518766007469 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 518766007470 anticodon binding site; other site 518766007471 hypothetical protein; Reviewed; Region: PRK00024 518766007472 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 518766007473 helix-hairpin-helix signature motif; other site 518766007474 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 518766007475 MPN+ (JAMM) motif; other site 518766007476 Zinc-binding site [ion binding]; other site 518766007477 transcription termination factor Rho; Provisional; Region: PRK12608 518766007478 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 518766007479 RNA binding site [nucleotide binding]; other site 518766007480 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 518766007481 Walker A motif; other site 518766007482 ATP binding site [chemical binding]; other site 518766007483 Walker B motif; other site 518766007484 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 518766007485 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 518766007486 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 518766007487 catalytic site [active] 518766007488 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 518766007489 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 518766007490 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 518766007491 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 518766007492 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 518766007493 putative active site [active] 518766007494 YdjC motif; other site 518766007495 Mg binding site [ion binding]; other site 518766007496 homodimer interface [polypeptide binding]; other site 518766007497 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 518766007498 RNA/DNA hybrid binding site [nucleotide binding]; other site 518766007499 active site 518766007500 shikimate kinase; Reviewed; Region: aroK; PRK00131 518766007501 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 518766007502 ADP binding site [chemical binding]; other site 518766007503 magnesium binding site [ion binding]; other site 518766007504 putative shikimate binding site; other site 518766007505 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 518766007506 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 518766007507 dimerization interface 3.5A [polypeptide binding]; other site 518766007508 active site 518766007509 Amidinotransferase; Region: Amidinotransf; cl12043 518766007510 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 518766007511 putative active site [active] 518766007512 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 518766007513 nucleoside/Zn binding site; other site 518766007514 dimer interface [polypeptide binding]; other site 518766007515 catalytic motif [active] 518766007516 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 518766007517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 518766007518 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 518766007519 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 518766007520 active site 518766007521 NTP binding site [chemical binding]; other site 518766007522 metal binding triad [ion binding]; metal-binding site 518766007523 antibiotic binding site [chemical binding]; other site 518766007524 Uncharacterized conserved protein [Function unknown]; Region: COG2361 518766007525 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 518766007526 G1 box; other site 518766007527 GTP/Mg2+ binding site [chemical binding]; other site 518766007528 Switch I region; other site 518766007529 G2 box; other site 518766007530 G3 box; other site 518766007531 Switch II region; other site 518766007532 G4 box; other site 518766007533 G5 box; other site 518766007534 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 518766007535 CoA binding domain; Region: CoA_binding; smart00881 518766007536 CoA-ligase; Region: Ligase_CoA; pfam00549 518766007537 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 518766007538 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 518766007539 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 518766007540 adenosine deaminase; Provisional; Region: PRK09358 518766007541 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 518766007542 active site 518766007543 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 518766007544 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 518766007545 hinge; other site 518766007546 active site 518766007547 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 518766007548 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 518766007549 DNA binding site [nucleotide binding] 518766007550 active site 518766007551 starch binding outer membrane protein SusD; Region: SusD; cl17845 518766007552 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 518766007553 FAD binding domain; Region: FAD_binding_4; pfam01565 518766007554 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 518766007555 PGAP1-like protein; Region: PGAP1; pfam07819 518766007556 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 518766007557 chaperone protein DnaJ; Provisional; Region: PRK14299 518766007558 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 518766007559 HSP70 interaction site [polypeptide binding]; other site 518766007560 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 518766007561 substrate binding site [polypeptide binding]; other site 518766007562 dimer interface [polypeptide binding]; other site 518766007563 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 518766007564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766007565 S-adenosylmethionine binding site [chemical binding]; other site 518766007566 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 518766007567 RNB domain; Region: RNB; pfam00773 518766007568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 518766007569 Protein of unknown function (DUF433); Region: DUF433; pfam04255 518766007570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766007571 S-adenosylmethionine binding site [chemical binding]; other site 518766007572 Response regulator receiver domain; Region: Response_reg; pfam00072 518766007573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766007574 active site 518766007575 phosphorylation site [posttranslational modification] 518766007576 intermolecular recognition site; other site 518766007577 dimerization interface [polypeptide binding]; other site 518766007578 PglZ domain; Region: PglZ; pfam08665 518766007579 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 518766007580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 518766007581 NAD(P) binding site [chemical binding]; other site 518766007582 active site 518766007583 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 518766007584 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 518766007585 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 518766007586 PA/protease or protease-like domain interface [polypeptide binding]; other site 518766007587 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 518766007588 metal binding site [ion binding]; metal-binding site 518766007589 Predicted dehydrogenase [General function prediction only]; Region: COG0579 518766007590 hydroxyglutarate oxidase; Provisional; Region: PRK11728 518766007591 metal-dependent hydrolase; Provisional; Region: PRK13291 518766007592 DinB superfamily; Region: DinB_2; pfam12867 518766007593 MjaI restriction endonuclease; Region: RE_MjaI; pfam09568 518766007594 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 518766007595 DNA methylase; Region: N6_N4_Mtase; pfam01555 518766007596 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 518766007597 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 518766007598 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 518766007599 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 518766007600 ammonium transporter; Region: amt; TIGR00836 518766007601 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 518766007602 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 518766007603 Nitrogen regulatory protein P-II; Region: P-II; smart00938 518766007604 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 518766007605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766007606 Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503 518766007607 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 518766007608 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 518766007609 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 518766007610 FtsX-like permease family; Region: FtsX; pfam02687 518766007611 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 518766007612 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 518766007613 FtsX-like permease family; Region: FtsX; pfam02687 518766007614 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 518766007615 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 518766007616 Walker A/P-loop; other site 518766007617 ATP binding site [chemical binding]; other site 518766007618 Q-loop/lid; other site 518766007619 ABC transporter signature motif; other site 518766007620 Walker B; other site 518766007621 D-loop; other site 518766007622 H-loop/switch region; other site 518766007623 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 518766007624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 518766007625 FeS/SAM binding site; other site 518766007626 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 518766007627 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 518766007628 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 518766007629 protein-splicing catalytic site; other site 518766007630 thioester formation/cholesterol transfer; other site 518766007631 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 518766007632 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 518766007633 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 518766007634 TSCPD domain; Region: TSCPD; pfam12637 518766007635 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 518766007636 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 518766007637 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 518766007638 active site 518766007639 NTP binding site [chemical binding]; other site 518766007640 metal binding triad [ion binding]; metal-binding site 518766007641 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 518766007642 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 518766007643 Zn2+ binding site [ion binding]; other site 518766007644 Mg2+ binding site [ion binding]; other site 518766007645 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 518766007646 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 518766007647 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 518766007648 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 518766007649 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 518766007650 putative ADP-ribose binding site [chemical binding]; other site 518766007651 putative active site [active] 518766007652 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 518766007653 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 518766007654 dimer interface [polypeptide binding]; other site 518766007655 active site 518766007656 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 518766007657 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 518766007658 putative active site [active] 518766007659 substrate binding site [chemical binding]; other site 518766007660 putative cosubstrate binding site; other site 518766007661 catalytic site [active] 518766007662 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 518766007663 substrate binding site [chemical binding]; other site 518766007664 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 518766007665 MoxR-like ATPases [General function prediction only]; Region: COG0714 518766007666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766007667 Walker A motif; other site 518766007668 ATP binding site [chemical binding]; other site 518766007669 Walker B motif; other site 518766007670 arginine finger; other site 518766007671 HPr kinase/phosphorylase; Provisional; Region: PRK05428 518766007672 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 518766007673 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 518766007674 Hpr binding site; other site 518766007675 active site 518766007676 homohexamer subunit interaction site [polypeptide binding]; other site 518766007677 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 518766007678 Peptidase family M23; Region: Peptidase_M23; pfam01551 518766007679 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 518766007680 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 518766007681 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 518766007682 Surface antigen; Region: Bac_surface_Ag; pfam01103 518766007683 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 518766007684 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 518766007685 ligand binding site [chemical binding]; other site 518766007686 flexible hinge region; other site 518766007687 TRAM domain; Region: TRAM; cl01282 518766007688 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 518766007689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766007690 S-adenosylmethionine binding site [chemical binding]; other site 518766007691 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 518766007692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 518766007693 NAD(P) binding site [chemical binding]; other site 518766007694 active site 518766007695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 518766007696 Major Facilitator Superfamily; Region: MFS_1; pfam07690 518766007697 putative substrate translocation pore; other site 518766007698 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766007699 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766007700 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766007701 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766007702 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 518766007703 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 518766007704 putative active site [active] 518766007705 putative metal binding site [ion binding]; other site 518766007706 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 518766007707 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 518766007708 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 518766007709 DHH family; Region: DHH; pfam01368 518766007710 DHHA1 domain; Region: DHHA1; pfam02272 518766007711 FeoA domain; Region: FeoA; cl00838 518766007712 FeoA domain; Region: FeoA; pfam04023 518766007713 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 518766007714 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 518766007715 G1 box; other site 518766007716 GTP/Mg2+ binding site [chemical binding]; other site 518766007717 Switch I region; other site 518766007718 G2 box; other site 518766007719 G3 box; other site 518766007720 Switch II region; other site 518766007721 G4 box; other site 518766007722 G5 box; other site 518766007723 Nucleoside recognition; Region: Gate; pfam07670 518766007724 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 518766007725 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 518766007726 Nucleoside recognition; Region: Gate; pfam07670 518766007727 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 518766007728 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 518766007729 CAAX protease self-immunity; Region: Abi; pfam02517 518766007730 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 518766007731 active site 518766007732 NTP binding site [chemical binding]; other site 518766007733 metal binding triad [ion binding]; metal-binding site 518766007734 antibiotic binding site [chemical binding]; other site 518766007735 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 518766007736 high affinity sulphate transporter 1; Region: sulP; TIGR00815 518766007737 Sulfate transporter family; Region: Sulfate_transp; pfam00916 518766007738 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 518766007739 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 518766007740 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 518766007741 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 518766007742 Methyltransferase domain; Region: Methyltransf_31; pfam13847 518766007743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766007744 S-adenosylmethionine binding site [chemical binding]; other site 518766007745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 518766007746 Coenzyme A binding pocket [chemical binding]; other site 518766007747 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 518766007748 dimerization interface [polypeptide binding]; other site 518766007749 putative DNA binding site [nucleotide binding]; other site 518766007750 putative Zn2+ binding site [ion binding]; other site 518766007751 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 518766007752 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 518766007753 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 518766007754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 518766007755 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 518766007756 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 518766007757 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 518766007758 4Fe-4S binding domain; Region: Fer4; pfam00037 518766007759 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 518766007760 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 518766007761 dimer interface [polypeptide binding]; other site 518766007762 PYR/PP interface [polypeptide binding]; other site 518766007763 TPP binding site [chemical binding]; other site 518766007764 substrate binding site [chemical binding]; other site 518766007765 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 518766007766 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 518766007767 TPP-binding site [chemical binding]; other site 518766007768 putative dimer interface [polypeptide binding]; other site 518766007769 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 518766007770 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 518766007771 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 518766007772 ligand binding site [chemical binding]; other site 518766007773 flexible hinge region; other site 518766007774 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 518766007775 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 518766007776 FAD binding pocket [chemical binding]; other site 518766007777 FAD binding motif [chemical binding]; other site 518766007778 phosphate binding motif [ion binding]; other site 518766007779 beta-alpha-beta structure motif; other site 518766007780 NAD binding pocket [chemical binding]; other site 518766007781 Iron coordination center [ion binding]; other site 518766007782 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 518766007783 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 518766007784 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 518766007785 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 518766007786 nickel binding site [ion binding]; other site 518766007787 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 518766007788 Acylphosphatase; Region: Acylphosphatase; pfam00708 518766007789 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 518766007790 HypF finger; Region: zf-HYPF; pfam07503 518766007791 HypF finger; Region: zf-HYPF; pfam07503 518766007792 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 518766007793 HupF/HypC family; Region: HupF_HypC; pfam01455 518766007794 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 518766007795 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 518766007796 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 518766007797 dimerization interface [polypeptide binding]; other site 518766007798 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 518766007799 ATP binding site [chemical binding]; other site 518766007800 alpha-galactosidase; Region: PLN02808; cl17638 518766007801 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 518766007802 Helix-turn-helix domain; Region: HTH_18; pfam12833 518766007803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 518766007804 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 518766007805 Tetratricopeptide repeat; Region: TPR_12; pfam13424 518766007806 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 518766007807 metal ion-dependent adhesion site (MIDAS); other site 518766007808 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 518766007809 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 518766007810 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 518766007811 Na binding site [ion binding]; other site 518766007812 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 518766007813 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 518766007814 active site 518766007815 homotrimer interface [polypeptide binding]; other site 518766007816 catalytic site [active] 518766007817 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 518766007818 thymidine kinase; Provisional; Region: PRK04296 518766007819 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 518766007820 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 518766007821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766007822 Walker A motif; other site 518766007823 ATP binding site [chemical binding]; other site 518766007824 Walker B motif; other site 518766007825 arginine finger; other site 518766007826 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 518766007827 Protein of unknown function (DUF721); Region: DUF721; pfam05258 518766007828 hypothetical protein; Validated; Region: PRK00153 518766007829 recombination protein RecR; Reviewed; Region: recR; PRK00076 518766007830 RecR protein; Region: RecR; pfam02132 518766007831 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 518766007832 putative active site [active] 518766007833 putative metal-binding site [ion binding]; other site 518766007834 tetramer interface [polypeptide binding]; other site 518766007835 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 518766007836 classical (c) SDRs; Region: SDR_c; cd05233 518766007837 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 518766007838 NAD(P) binding site [chemical binding]; other site 518766007839 active site 518766007840 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 518766007841 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766007842 putative ADP-binding pocket [chemical binding]; other site 518766007843 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 518766007844 Domain of unknown function (DUF377); Region: DUF377; pfam04041 518766007845 active site 518766007846 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 518766007847 active site 518766007848 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 518766007849 active site 518766007850 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 518766007851 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 518766007852 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 518766007853 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 518766007854 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766007855 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 518766007856 DNA binding residues [nucleotide binding] 518766007857 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 518766007858 Ferritin-like domain; Region: Ferritin; pfam00210 518766007859 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 518766007860 dinuclear metal binding motif [ion binding]; other site 518766007861 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 518766007862 putative catalytic site [active] 518766007863 putative phosphate binding site [ion binding]; other site 518766007864 active site 518766007865 metal binding site A [ion binding]; metal-binding site 518766007866 DNA binding site [nucleotide binding] 518766007867 putative AP binding site [nucleotide binding]; other site 518766007868 putative metal binding site B [ion binding]; other site 518766007869 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 518766007870 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 518766007871 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 518766007872 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 518766007873 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 518766007874 SLBB domain; Region: SLBB; pfam10531 518766007875 SLBB domain; Region: SLBB; pfam10531 518766007876 Chain length determinant protein; Region: Wzz; cl15801 518766007877 Surface antigen; Region: Bac_surface_Ag; pfam01103 518766007878 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 518766007879 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 518766007880 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 518766007881 DNA binding residues [nucleotide binding] 518766007882 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 518766007883 DNA polymerase III, delta subunit; Region: holA; TIGR01128 518766007884 DinB superfamily; Region: DinB_2; pfam12867 518766007885 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 518766007886 4Fe-4S binding domain; Region: Fer4; cl02805 518766007887 4Fe-4S binding domain; Region: Fer4; pfam00037 518766007888 GTP-binding protein Der; Reviewed; Region: PRK00093 518766007889 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 518766007890 G1 box; other site 518766007891 GTP/Mg2+ binding site [chemical binding]; other site 518766007892 Switch I region; other site 518766007893 G2 box; other site 518766007894 Switch II region; other site 518766007895 G3 box; other site 518766007896 G4 box; other site 518766007897 G5 box; other site 518766007898 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 518766007899 G1 box; other site 518766007900 GTP/Mg2+ binding site [chemical binding]; other site 518766007901 Switch I region; other site 518766007902 G2 box; other site 518766007903 G3 box; other site 518766007904 Switch II region; other site 518766007905 G4 box; other site 518766007906 G5 box; other site 518766007907 EcsC protein family; Region: EcsC; pfam12787 518766007908 Bacitracin resistance protein BacA; Region: BacA; pfam02673 518766007909 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 518766007910 Domain of unknown function (DUF814); Region: DUF814; pfam05670 518766007911 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 518766007912 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 518766007913 short chain dehydrogenase; Provisional; Region: PRK07326 518766007914 classical (c) SDRs; Region: SDR_c; cd05233 518766007915 NAD(P) binding site [chemical binding]; other site 518766007916 active site 518766007917 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 518766007918 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 518766007919 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 518766007920 Penicillinase repressor; Region: Pencillinase_R; pfam03965 518766007921 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 518766007922 active site 518766007923 catalytic triad [active] 518766007924 oxyanion hole [active] 518766007925 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 518766007926 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 518766007927 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 518766007928 DinB superfamily; Region: DinB_2; pfam12867 518766007929 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 518766007930 Predicted esterase [General function prediction only]; Region: COG0400 518766007931 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 518766007932 DctM-like transporters; Region: DctM; pfam06808 518766007933 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 518766007934 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 518766007935 4Fe-4S binding domain; Region: Fer4; cl02805 518766007936 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 518766007937 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 518766007938 active site 518766007939 dimer interfaces [polypeptide binding]; other site 518766007940 catalytic residues [active] 518766007941 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 518766007942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 518766007943 Walker A motif; other site 518766007944 ATP binding site [chemical binding]; other site 518766007945 Walker B motif; other site 518766007946 arginine finger; other site 518766007947 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 518766007948 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 518766007949 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 518766007950 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 518766007951 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 518766007952 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 518766007953 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 518766007954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766007955 dimer interface [polypeptide binding]; other site 518766007956 phosphorylation site [posttranslational modification] 518766007957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766007958 ATP binding site [chemical binding]; other site 518766007959 Mg2+ binding site [ion binding]; other site 518766007960 G-X-G motif; other site 518766007961 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 518766007962 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 518766007963 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 518766007964 catalytic residue [active] 518766007965 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 518766007966 active site 518766007967 catalytic residues [active] 518766007968 metal binding site [ion binding]; metal-binding site 518766007969 glycine dehydrogenase; Provisional; Region: PRK05367 518766007970 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 518766007971 tetramer interface [polypeptide binding]; other site 518766007972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766007973 catalytic residue [active] 518766007974 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 518766007975 tetramer interface [polypeptide binding]; other site 518766007976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 518766007977 catalytic residue [active] 518766007978 Protein of unknown function DUF89; Region: DUF89; pfam01937 518766007979 ribonuclease III; Reviewed; Region: rnc; PRK00102 518766007980 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 518766007981 dimerization interface [polypeptide binding]; other site 518766007982 active site 518766007983 metal binding site [ion binding]; metal-binding site 518766007984 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 518766007985 dsRNA binding site [nucleotide binding]; other site 518766007986 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 518766007987 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 518766007988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 518766007989 putative cation:proton antiport protein; Provisional; Region: PRK10669 518766007990 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 518766007991 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 518766007992 TrkA-N domain; Region: TrkA_N; pfam02254 518766007993 TrkA-C domain; Region: TrkA_C; pfam02080 518766007994 Nitrogen regulatory protein P-II; Region: P-II; cl00412 518766007995 Domain of unknown function (DUF897); Region: DUF897; pfam05982 518766007996 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 518766007997 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 518766007998 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 518766007999 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 518766008000 TrkA-N domain; Region: TrkA_N; pfam02254 518766008001 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 518766008002 active site 518766008003 phosphorylation site [posttranslational modification] 518766008004 HEPN domain; Region: HEPN; pfam05168 518766008005 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 518766008006 active site 518766008007 NTP binding site [chemical binding]; other site 518766008008 metal binding triad [ion binding]; metal-binding site 518766008009 antibiotic binding site [chemical binding]; other site 518766008010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766008011 dimer interface [polypeptide binding]; other site 518766008012 phosphorylation site [posttranslational modification] 518766008013 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 518766008014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766008015 ATP binding site [chemical binding]; other site 518766008016 Mg2+ binding site [ion binding]; other site 518766008017 G-X-G motif; other site 518766008018 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 518766008019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766008020 active site 518766008021 phosphorylation site [posttranslational modification] 518766008022 intermolecular recognition site; other site 518766008023 dimerization interface [polypeptide binding]; other site 518766008024 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 518766008025 DNA binding site [nucleotide binding] 518766008026 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 518766008027 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 518766008028 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 518766008029 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 518766008030 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 518766008031 N-terminal plug; other site 518766008032 MarR family; Region: MarR_2; cl17246 518766008033 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 518766008034 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 518766008035 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 518766008036 homodimer interface [polypeptide binding]; other site 518766008037 substrate-cofactor binding pocket; other site 518766008038 catalytic residue [active] 518766008039 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 518766008040 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 518766008041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 518766008042 Coenzyme A binding pocket [chemical binding]; other site 518766008043 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 518766008044 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 518766008045 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 518766008046 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 518766008047 protein binding site [polypeptide binding]; other site 518766008048 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 518766008049 pseudouridine synthase; Region: TIGR00093 518766008050 active site 518766008051 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 518766008052 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 518766008053 homotetramer interface [polypeptide binding]; other site 518766008054 ligand binding site [chemical binding]; other site 518766008055 catalytic site [active] 518766008056 NAD binding site [chemical binding]; other site 518766008057 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 518766008058 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 518766008059 Zn binding site [ion binding]; other site 518766008060 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 518766008061 S-adenosylmethionine synthetase; Validated; Region: PRK05250 518766008062 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 518766008063 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 518766008064 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 518766008065 acyl carrier protein; Provisional; Region: acpP; PRK00982 518766008066 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 518766008067 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 518766008068 dimer interface [polypeptide binding]; other site 518766008069 active site 518766008070 Protein of unknown function (DUF721); Region: DUF721; pfam05258 518766008071 Outer membrane efflux protein; Region: OEP; pfam02321 518766008072 Outer membrane efflux protein; Region: OEP; pfam02321 518766008073 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 518766008074 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 518766008075 active site 518766008076 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 518766008077 cell division protein FtsZ; Validated; Region: PRK09330 518766008078 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 518766008079 nucleotide binding site [chemical binding]; other site 518766008080 SulA interaction site; other site 518766008081 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 518766008082 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 518766008083 nucleotide binding site [chemical binding]; other site 518766008084 Cell division protein FtsA; Region: FtsA; pfam14450 518766008085 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 518766008086 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 518766008087 Cell division protein FtsQ; Region: FtsQ; pfam03799 518766008088 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 518766008089 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 518766008090 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 518766008091 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 518766008092 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 518766008093 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 518766008094 active site 518766008095 homodimer interface [polypeptide binding]; other site 518766008096 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 518766008097 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 518766008098 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 518766008099 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 518766008100 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 518766008101 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 518766008102 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 518766008103 Mg++ binding site [ion binding]; other site 518766008104 putative catalytic motif [active] 518766008105 putative substrate binding site [chemical binding]; other site 518766008106 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 518766008107 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 518766008108 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 518766008109 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 518766008110 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 518766008111 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 518766008112 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 518766008113 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 518766008114 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 518766008115 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 518766008116 MraW methylase family; Region: Methyltransf_5; cl17771 518766008117 cell division protein MraZ; Reviewed; Region: PRK00326 518766008118 MraZ protein; Region: MraZ; pfam02381 518766008119 MraZ protein; Region: MraZ; pfam02381 518766008120 LexA repressor; Validated; Region: PRK00215 518766008121 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 518766008122 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 518766008123 Catalytic site [active] 518766008124 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 518766008125 CTP synthetase; Validated; Region: pyrG; PRK05380 518766008126 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 518766008127 Catalytic site [active] 518766008128 active site 518766008129 UTP binding site [chemical binding]; other site 518766008130 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 518766008131 active site 518766008132 putative oxyanion hole; other site 518766008133 catalytic triad [active] 518766008134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766008135 S-adenosylmethionine binding site [chemical binding]; other site 518766008136 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766008137 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 518766008138 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 518766008139 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 518766008140 Ligand binding site; other site 518766008141 Putative Catalytic site; other site 518766008142 DXD motif; other site 518766008143 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 518766008144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766008145 ATP binding site [chemical binding]; other site 518766008146 Mg2+ binding site [ion binding]; other site 518766008147 G-X-G motif; other site 518766008148 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 518766008149 anchoring element; other site 518766008150 dimer interface [polypeptide binding]; other site 518766008151 ATP binding site [chemical binding]; other site 518766008152 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 518766008153 active site 518766008154 putative metal-binding site [ion binding]; other site 518766008155 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 518766008156 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 518766008157 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 518766008158 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 518766008159 active site 518766008160 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 518766008161 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 518766008162 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 518766008163 HflX GTPase family; Region: HflX; cd01878 518766008164 G1 box; other site 518766008165 GTP/Mg2+ binding site [chemical binding]; other site 518766008166 Switch I region; other site 518766008167 G2 box; other site 518766008168 G3 box; other site 518766008169 Switch II region; other site 518766008170 G4 box; other site 518766008171 G5 box; other site 518766008172 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 518766008173 von Willebrand factor type A domain; Region: VWA_2; pfam13519 518766008174 CARDB; Region: CARDB; pfam07705 518766008175 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 518766008176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 518766008177 S-adenosylmethionine binding site [chemical binding]; other site 518766008178 HDOD domain; Region: HDOD; pfam08668 518766008179 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 518766008180 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 518766008181 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 518766008182 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 518766008183 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 518766008184 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 518766008185 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 518766008186 Cupin domain; Region: Cupin_2; pfam07883 518766008187 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 518766008188 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 518766008189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 518766008190 ABC transporter signature motif; other site 518766008191 Walker B; other site 518766008192 D-loop; other site 518766008193 H-loop/switch region; other site 518766008194 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 518766008195 Protein of unknown function DUF86; Region: DUF86; pfam01934 518766008196 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 518766008197 active site 518766008198 NTP binding site [chemical binding]; other site 518766008199 metal binding triad [ion binding]; metal-binding site 518766008200 antibiotic binding site [chemical binding]; other site 518766008201 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 518766008202 methionine sulfoxide reductase A; Provisional; Region: PRK14054 518766008203 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766008204 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 518766008205 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766008206 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 518766008207 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 518766008208 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 518766008209 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 518766008210 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 518766008211 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 518766008212 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 518766008213 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 518766008214 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 518766008215 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 518766008216 active site 518766008217 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 518766008218 dimer interaction site [polypeptide binding]; other site 518766008219 substrate-binding tunnel; other site 518766008220 active site 518766008221 catalytic site [active] 518766008222 substrate binding site [chemical binding]; other site 518766008223 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 518766008224 Peptidase family M48; Region: Peptidase_M48; cl12018 518766008225 recombination protein F; Reviewed; Region: recF; PRK00064 518766008226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 518766008227 Walker A/P-loop; other site 518766008228 ATP binding site [chemical binding]; other site 518766008229 Q-loop/lid; other site 518766008230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 518766008231 ABC transporter signature motif; other site 518766008232 Walker B; other site 518766008233 D-loop; other site 518766008234 H-loop/switch region; other site 518766008235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766008236 TPR motif; other site 518766008237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766008238 binding surface 518766008239 TPR motif; other site 518766008240 Tetratricopeptide repeat; Region: TPR_12; pfam13424 518766008241 CHAT domain; Region: CHAT; pfam12770 518766008242 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 518766008243 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 518766008244 putative active site [active] 518766008245 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 518766008246 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 518766008247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 518766008248 ATP binding site [chemical binding]; other site 518766008249 putative Mg++ binding site [ion binding]; other site 518766008250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 518766008251 nucleotide binding region [chemical binding]; other site 518766008252 ATP-binding site [chemical binding]; other site 518766008253 TRCF domain; Region: TRCF; pfam03461 518766008254 Predicted transcriptional regulator [Transcription]; Region: COG2378 518766008255 HTH domain; Region: HTH_11; pfam08279 518766008256 WYL domain; Region: WYL; pfam13280 518766008257 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 518766008258 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 518766008259 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 518766008260 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 518766008261 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 518766008262 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766008263 PAS fold; Region: PAS_3; pfam08447 518766008264 putative active site [active] 518766008265 heme pocket [chemical binding]; other site 518766008266 PAS domain; Region: PAS_9; pfam13426 518766008267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766008268 putative active site [active] 518766008269 heme pocket [chemical binding]; other site 518766008270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766008271 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 518766008272 putative active site [active] 518766008273 heme pocket [chemical binding]; other site 518766008274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766008275 dimer interface [polypeptide binding]; other site 518766008276 phosphorylation site [posttranslational modification] 518766008277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766008278 ATP binding site [chemical binding]; other site 518766008279 Mg2+ binding site [ion binding]; other site 518766008280 G-X-G motif; other site 518766008281 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 518766008282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 518766008283 active site 518766008284 phosphorylation site [posttranslational modification] 518766008285 intermolecular recognition site; other site 518766008286 dimerization interface [polypeptide binding]; other site 518766008287 PAS domain S-box; Region: sensory_box; TIGR00229 518766008288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766008289 putative active site [active] 518766008290 heme pocket [chemical binding]; other site 518766008291 PAS domain S-box; Region: sensory_box; TIGR00229 518766008292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766008293 putative active site [active] 518766008294 heme pocket [chemical binding]; other site 518766008295 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 518766008296 GAF domain; Region: GAF; pfam01590 518766008297 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 518766008298 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 518766008299 putative active site [active] 518766008300 heme pocket [chemical binding]; other site 518766008301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 518766008302 dimer interface [polypeptide binding]; other site 518766008303 phosphorylation site [posttranslational modification] 518766008304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 518766008305 ATP binding site [chemical binding]; other site 518766008306 Mg2+ binding site [ion binding]; other site 518766008307 G-X-G motif; other site 518766008308 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 518766008309 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 518766008310 trmE is a tRNA modification GTPase; Region: trmE; cd04164 518766008311 G1 box; other site 518766008312 GTP/Mg2+ binding site [chemical binding]; other site 518766008313 Switch I region; other site 518766008314 G2 box; other site 518766008315 Switch II region; other site 518766008316 G3 box; other site 518766008317 G4 box; other site 518766008318 G5 box; other site 518766008319 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 518766008320 membrane protein insertase; Provisional; Region: PRK01318 518766008321 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 518766008322 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 518766008323 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 518766008324 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 518766008325 FAD binding domain; Region: FAD_binding_4; pfam01565 518766008326 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 518766008327 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 518766008328 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 518766008329 catalytic loop [active] 518766008330 iron binding site [ion binding]; other site 518766008331 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 518766008332 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 518766008333 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 518766008334 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 518766008335 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 518766008336 putative hydrophobic ligand binding site [chemical binding]; other site 518766008337 MoxR-like ATPases [General function prediction only]; Region: COG0714 518766008338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 518766008339 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 518766008340 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 518766008341 metal ion-dependent adhesion site (MIDAS); other site 518766008342 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 518766008343 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 518766008344 XdhC Rossmann domain; Region: XdhC_C; pfam13478 518766008345 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 518766008346 metal-binding site [ion binding] 518766008347 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 518766008348 Ligand binding site; other site 518766008349 metal-binding site 518766008350 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 518766008351 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 518766008352 XdhC Rossmann domain; Region: XdhC_C; pfam13478 518766008353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 518766008354 putative substrate translocation pore; other site 518766008355 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 518766008356 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 518766008357 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 518766008358 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 518766008359 heme-binding site [chemical binding]; other site 518766008360 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 518766008361 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 518766008362 [4Fe-4S] binding site [ion binding]; other site 518766008363 molybdopterin cofactor binding site; other site 518766008364 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 518766008365 molybdopterin cofactor binding site; other site 518766008366 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 518766008367 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 518766008368 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 518766008369 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 518766008370 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 518766008371 tetramer interface [polypeptide binding]; other site 518766008372 heme binding pocket [chemical binding]; other site 518766008373 NADPH binding site [chemical binding]; other site 518766008374 Transcriptional regulator [Transcription]; Region: LysR; COG0583 518766008375 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 518766008376 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 518766008377 dimerization interface [polypeptide binding]; other site 518766008378 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 518766008379 dimerization interface [polypeptide binding]; other site 518766008380 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 518766008381 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 518766008382 dimer interface [polypeptide binding]; other site 518766008383 putative CheW interface [polypeptide binding]; other site 518766008384 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 518766008385 dimanganese center [ion binding]; other site 518766008386 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 518766008387 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 518766008388 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766008389 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 518766008390 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 518766008391 N-terminal plug; other site 518766008392 ligand-binding site [chemical binding]; other site 518766008393 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 518766008394 MgtE intracellular N domain; Region: MgtE_N; smart00924 518766008395 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 518766008396 Divalent cation transporter; Region: MgtE; pfam01769 518766008397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 518766008398 TPR motif; other site 518766008399 binding surface 518766008400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766008401 binding surface 518766008402 TPR repeat; Region: TPR_11; pfam13414 518766008403 TPR motif; other site 518766008404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 518766008405 binding surface 518766008406 TPR motif; other site 518766008407 TPR repeat; Region: TPR_11; pfam13414 518766008408 Transcriptional regulators [Transcription]; Region: PurR; COG1609 518766008409 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 518766008410 DNA binding site [nucleotide binding] 518766008411 domain linker motif; other site 518766008412 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 518766008413 ligand binding site [chemical binding]; other site 518766008414 dimerization interface [polypeptide binding]; other site 518766008415 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 518766008416 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 518766008417 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 518766008418 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 518766008419 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 518766008420 active site 518766008421 trimer interface [polypeptide binding]; other site 518766008422 allosteric site; other site 518766008423 active site lid [active] 518766008424 hexamer (dimer of trimers) interface [polypeptide binding]; other site 518766008425 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 518766008426 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 518766008427 putative ligand binding site [chemical binding]; other site 518766008428 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 518766008429 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 518766008430 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 518766008431 starch binding outer membrane protein SusD; Region: SusD; cl17845 518766008432 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 518766008433 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 518766008434 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 518766008435 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 518766008436 active site 518766008437 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 518766008438 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 518766008439 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 518766008440 catalytic triad [active] 518766008441 Protein of unknown function, DUF399; Region: DUF399; pfam04187 518766008442 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 518766008443 DEAD-like helicases superfamily; Region: DEXDc; smart00487 518766008444 ATP binding site [chemical binding]; other site 518766008445 Mg++ binding site [ion binding]; other site 518766008446 motif III; other site 518766008447 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 518766008448 nucleotide binding region [chemical binding]; other site 518766008449 ATP-binding site [chemical binding]; other site 518766008450 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 518766008451 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 518766008452 NAD(P) binding site [chemical binding]; other site 518766008453 homotetramer interface [polypeptide binding]; other site 518766008454 homodimer interface [polypeptide binding]; other site 518766008455 active site 518766008456 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 518766008457 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 518766008458 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 518766008459 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 518766008460 dimer interface [polypeptide binding]; other site 518766008461 active site 518766008462 CoA binding pocket [chemical binding]; other site 518766008463 putative phosphate acyltransferase; Provisional; Region: PRK05331 518766008464 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 518766008465 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 518766008466 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 518766008467 CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621 518766008468 CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165 518766008469 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 518766008470 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 518766008471 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 518766008472 non-specific DNA binding site [nucleotide binding]; other site 518766008473 salt bridge; other site 518766008474 sequence-specific DNA binding site [nucleotide binding]; other site 518766008475 Domain of unknown function (DUF955); Region: DUF955; cl01076 518766008476 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 518766008477 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 518766008478 amidase catalytic site [active] 518766008479 Zn binding residues [ion binding]; other site 518766008480 substrate binding site [chemical binding]; other site 518766008481 Cna protein B-type domain; Region: Cna_B_2; pfam13715 518766008482 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 518766008483 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 518766008484 Family description; Region: VCBS; pfam13517 518766008485 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 518766008486 Archaeal ATPase; Region: Arch_ATPase; pfam01637 518766008487 AAA domain; Region: AAA_14; pfam13173 518766008488 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 518766008489 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 518766008490 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 518766008491 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 518766008492 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 518766008493 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 518766008494 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 518766008495 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 518766008496 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839 518766008497 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 518766008498 DNA binding residues [nucleotide binding] 518766008499 dimerization interface [polypeptide binding]; other site 518766008500 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 518766008501 JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744 518766008502 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 518766008503 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 518766008504 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 518766008505 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839 518766008506 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 518766008507 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 518766008508 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 518766008509 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 518766008510 HSP70 interaction site [polypeptide binding]; other site 518766008511 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 518766008512 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 518766008513 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 518766008514 Protein of unknown function, DUF488; Region: DUF488; pfam04343 518766008515 Protein of unknown function, DUF488; Region: DUF488; pfam04343 518766008516 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 518766008517 AAA domain; Region: AAA_30; pfam13604 518766008518 AAA domain; Region: AAA_22; pfam13401 518766008519 Family description; Region: UvrD_C_2; pfam13538 518766008520 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 518766008521 CRISPR-associated protein, TIGR02710 family; Region: TIGR02710 518766008522 DEAD-like helicases superfamily; Region: DEXDc; smart00487 518766008523 Protein of unknown function (DUF342); Region: DUF342; pfam03961 518766008524 DEAD-like helicases superfamily; Region: DEXDc; smart00487 518766008525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 518766008526 ATP binding site [chemical binding]; other site 518766008527 putative Mg++ binding site [ion binding]; other site 518766008528 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 518766008529 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 518766008530 ATP-binding site [chemical binding]; other site 518766008531 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 518766008532 active site 518766008533 substrate binding site [chemical binding]; other site 518766008534 catalytic site [active] 518766008535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 518766008536 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 518766008537 Probable transposase; Region: OrfB_IS605; pfam01385 518766008538 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 518766008539 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 518766008540 putative active site [active] 518766008541 homotetrameric interface [polypeptide binding]; other site 518766008542 metal binding site [ion binding]; metal-binding site 518766008543 HEPN domain; Region: HEPN; pfam05168 518766008544 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 518766008545 active site 518766008546 NTP binding site [chemical binding]; other site 518766008547 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 518766008548 CHASE3 domain; Region: CHASE3; pfam05227 518766008549 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 518766008550 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 518766008551 dimerization interface [polypeptide binding]; other site 518766008552 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 518766008553 dimerization interface [polypeptide binding]; other site 518766008554 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 518766008555 dimer interface [polypeptide binding]; other site 518766008556 putative CheW interface [polypeptide binding]; other site 518766008557 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 518766008558 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 518766008559 P-loop; other site 518766008560 Magnesium ion binding site [ion binding]; other site 518766008561 DDE superfamily endonuclease; Region: DDE_3; pfam13358 518766008562 Homeodomain-like domain; Region: HTH_23; pfam13384 518766008563 Winged helix-turn helix; Region: HTH_29; pfam13551 518766008564 Homeodomain-like domain; Region: HTH_32; pfam13565 518766008565 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 518766008566 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 518766008567 Probable transposase; Region: OrfB_IS605; pfam01385 518766008568 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 518766008569 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 518766008570 PIN domain; Region: PIN_3; cl17397 518766008571 Predicted transcriptional regulator [Transcription]; Region: COG3905 518766008572 Predicted transcriptional regulator [Transcription]; Region: COG2378 518766008573 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 518766008574 putative DNA binding site [nucleotide binding]; other site 518766008575 putative Zn2+ binding site [ion binding]; other site 518766008576 WYL domain; Region: WYL; pfam13280 518766008577 Restriction endonuclease EcoRV; Region: Endonuc-EcoRV; pfam09233 518766008578 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 518766008579 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 518766008580 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 518766008581 ATP binding site [chemical binding]; other site 518766008582 putative Mg++ binding site [ion binding]; other site 518766008583 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 518766008584 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 518766008585 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 518766008586 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 518766008587 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 518766008588 Part of AAA domain; Region: AAA_19; pfam13245 518766008589 Homeodomain-like domain; Region: HTH_23; pfam13384 518766008590 Winged helix-turn helix; Region: HTH_29; pfam13551 518766008591 Homeodomain-like domain; Region: HTH_32; pfam13565 518766008592 Winged helix-turn helix; Region: HTH_33; pfam13592 518766008593 DDE superfamily endonuclease; Region: DDE_3; pfam13358 518766008594 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 518766008595 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 518766008596 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634