-- dump date 20140620_033250 -- class Genbank::misc_feature -- table misc_feature_note -- id note 762570000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 762570000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 762570000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570000004 Walker A motif; other site 762570000005 ATP binding site [chemical binding]; other site 762570000006 Walker B motif; other site 762570000007 arginine finger; other site 762570000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 762570000009 DnaA box-binding interface [nucleotide binding]; other site 762570000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 762570000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 762570000012 putative DNA binding surface [nucleotide binding]; other site 762570000013 dimer interface [polypeptide binding]; other site 762570000014 beta-clamp/clamp loader binding surface; other site 762570000015 beta-clamp/translesion DNA polymerase binding surface; other site 762570000016 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 762570000017 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570000018 DNA binding residues [nucleotide binding] 762570000019 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 762570000020 23S rRNA interface [nucleotide binding]; other site 762570000021 L3 interface [polypeptide binding]; other site 762570000022 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 762570000023 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 762570000024 rRNA interaction site [nucleotide binding]; other site 762570000025 S8 interaction site; other site 762570000026 putative laminin-1 binding site; other site 762570000027 elongation factor Ts; Provisional; Region: tsf; PRK09377 762570000028 UBA/TS-N domain; Region: UBA; pfam00627 762570000029 Elongation factor TS; Region: EF_TS; pfam00889 762570000030 Elongation factor TS; Region: EF_TS; pfam00889 762570000031 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 762570000032 putative nucleotide binding site [chemical binding]; other site 762570000033 uridine monophosphate binding site [chemical binding]; other site 762570000034 homohexameric interface [polypeptide binding]; other site 762570000035 ribosome recycling factor; Reviewed; Region: frr; PRK00083 762570000036 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 762570000037 hinge region; other site 762570000038 hypothetical protein; Provisional; Region: PRK11820 762570000039 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 762570000040 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 762570000041 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 762570000042 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 762570000043 catalytic site [active] 762570000044 G-X2-G-X-G-K; other site 762570000045 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 762570000046 Flavoprotein; Region: Flavoprotein; pfam02441 762570000047 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 762570000048 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 762570000049 Fe-S cluster binding site [ion binding]; other site 762570000050 active site 762570000051 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 762570000052 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 762570000053 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 762570000054 Walker A motif; other site 762570000055 ATP binding site [chemical binding]; other site 762570000056 Walker B motif; other site 762570000057 DNA binding loops [nucleotide binding] 762570000058 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 762570000059 protein-splicing catalytic site; other site 762570000060 thioester formation/cholesterol transfer; other site 762570000061 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 762570000062 protein-splicing catalytic site; other site 762570000063 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762570000064 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 762570000065 putative metal binding site [ion binding]; other site 762570000066 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 762570000067 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570000068 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 762570000069 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 762570000070 dimer interface [polypeptide binding]; other site 762570000071 active site residues [active] 762570000072 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 762570000073 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 762570000074 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 762570000075 ribosomal protein L33; Region: rpl33; CHL00104 762570000076 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 762570000077 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 762570000078 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 762570000079 FtsX-like permease family; Region: FtsX; pfam02687 762570000080 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 762570000081 GTP-binding protein YchF; Reviewed; Region: PRK09601 762570000082 YchF GTPase; Region: YchF; cd01900 762570000083 G1 box; other site 762570000084 GTP/Mg2+ binding site [chemical binding]; other site 762570000085 Switch I region; other site 762570000086 G2 box; other site 762570000087 Switch II region; other site 762570000088 G3 box; other site 762570000089 G4 box; other site 762570000090 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 762570000091 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 762570000092 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 762570000093 active site 762570000094 metal binding site [ion binding]; metal-binding site 762570000095 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 762570000096 putative RNA binding site [nucleotide binding]; other site 762570000097 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 762570000098 Competence protein; Region: Competence; cl00471 762570000099 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762570000100 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762570000101 Ligand Binding Site [chemical binding]; other site 762570000102 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762570000103 Ligand Binding Site [chemical binding]; other site 762570000104 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 762570000105 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 762570000106 active site 762570000107 dimer interface [polypeptide binding]; other site 762570000108 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 762570000109 dimer interface [polypeptide binding]; other site 762570000110 active site 762570000111 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 762570000112 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 762570000113 dimer interface [polypeptide binding]; other site 762570000114 putative functional site; other site 762570000115 putative MPT binding site; other site 762570000116 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 762570000117 putative catalytic residue [active] 762570000118 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 762570000119 active site 762570000120 Ap6A binding site [chemical binding]; other site 762570000121 nudix motif; other site 762570000122 metal binding site [ion binding]; metal-binding site 762570000123 Uncharacterized conserved protein [Function unknown]; Region: COG2850 762570000124 Cupin-like domain; Region: Cupin_8; pfam13621 762570000125 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 762570000126 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 762570000127 dimer interface [polypeptide binding]; other site 762570000128 ADP-ribose binding site [chemical binding]; other site 762570000129 active site 762570000130 nudix motif; other site 762570000131 metal binding site [ion binding]; metal-binding site 762570000132 Ion transport protein; Region: Ion_trans; pfam00520 762570000133 Ion channel; Region: Ion_trans_2; pfam07885 762570000134 Double zinc ribbon; Region: DZR; pfam12773 762570000135 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 762570000136 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 762570000137 putative uracil binding site [chemical binding]; other site 762570000138 putative active site [active] 762570000139 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 762570000140 FG-GAP repeat; Region: FG-GAP_2; pfam14312 762570000141 FG-GAP repeat; Region: FG-GAP_2; pfam14312 762570000142 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570000143 active site 762570000144 NTP binding site [chemical binding]; other site 762570000145 metal binding triad [ion binding]; metal-binding site 762570000146 antibiotic binding site [chemical binding]; other site 762570000147 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 762570000148 Protein of unknown function (DUF524); Region: DUF524; pfam04411 762570000149 EVE domain; Region: EVE; cl00728 762570000150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 762570000151 excinuclease ABC subunit B; Provisional; Region: PRK05298 762570000152 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762570000153 ATP binding site [chemical binding]; other site 762570000154 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762570000155 nucleotide binding region [chemical binding]; other site 762570000156 ATP-binding site [chemical binding]; other site 762570000157 Ultra-violet resistance protein B; Region: UvrB; pfam12344 762570000158 UvrB/uvrC motif; Region: UVR; pfam02151 762570000159 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 762570000160 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570000161 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570000162 DNA binding residues [nucleotide binding] 762570000163 FecR protein; Region: FecR; pfam04773 762570000164 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762570000165 Secretin and TonB N terminus short domain; Region: STN; smart00965 762570000166 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570000167 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 762570000168 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 762570000169 iron-sulfur cluster [ion binding]; other site 762570000170 [2Fe-2S] cluster binding site [ion binding]; other site 762570000171 YceI-like domain; Region: YceI; pfam04264 762570000172 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 762570000173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762570000174 Walker A/P-loop; other site 762570000175 ATP binding site [chemical binding]; other site 762570000176 Q-loop/lid; other site 762570000177 ABC transporter signature motif; other site 762570000178 Walker B; other site 762570000179 D-loop; other site 762570000180 H-loop/switch region; other site 762570000181 TOBE domain; Region: TOBE; cl01440 762570000182 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 762570000183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762570000184 dimer interface [polypeptide binding]; other site 762570000185 conserved gate region; other site 762570000186 putative PBP binding loops; other site 762570000187 ABC-ATPase subunit interface; other site 762570000188 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 762570000189 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762570000190 Predicted transcriptional regulators [Transcription]; Region: COG1695 762570000191 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 762570000192 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 762570000193 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 762570000194 active site 762570000195 catalytic site [active] 762570000196 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 762570000197 Methyltransferase domain; Region: Methyltransf_23; pfam13489 762570000198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570000199 S-adenosylmethionine binding site [chemical binding]; other site 762570000200 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 762570000201 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762570000202 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762570000203 HlyD family secretion protein; Region: HlyD_3; pfam13437 762570000204 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762570000205 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762570000206 Walker A/P-loop; other site 762570000207 ATP binding site [chemical binding]; other site 762570000208 Q-loop/lid; other site 762570000209 ABC transporter signature motif; other site 762570000210 Walker B; other site 762570000211 D-loop; other site 762570000212 H-loop/switch region; other site 762570000213 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 762570000214 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 762570000215 active site 762570000216 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 762570000217 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 762570000218 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762570000219 catalytic residue [active] 762570000220 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762570000221 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762570000222 dimer interface [polypeptide binding]; other site 762570000223 putative CheW interface [polypeptide binding]; other site 762570000224 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 762570000225 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 762570000226 gamma subunit interface [polypeptide binding]; other site 762570000227 epsilon subunit interface [polypeptide binding]; other site 762570000228 LBP interface [polypeptide binding]; other site 762570000229 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 762570000230 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762570000231 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 762570000232 alpha subunit interaction interface [polypeptide binding]; other site 762570000233 Walker A motif; other site 762570000234 ATP binding site [chemical binding]; other site 762570000235 Walker B motif; other site 762570000236 inhibitor binding site; inhibition site 762570000237 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 762570000238 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 762570000239 putative active site [active] 762570000240 Zn binding site [ion binding]; other site 762570000241 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 762570000242 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 762570000243 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 762570000244 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 762570000245 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 762570000246 Ribosomal protein L31; Region: Ribosomal_L31; pfam01197 762570000247 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 762570000248 ThiC-associated domain; Region: ThiC-associated; pfam13667 762570000249 ThiC family; Region: ThiC; pfam01964 762570000250 HEPN domain; Region: HEPN; cl00824 762570000251 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570000252 active site 762570000253 NTP binding site [chemical binding]; other site 762570000254 metal binding triad [ion binding]; metal-binding site 762570000255 antibiotic binding site [chemical binding]; other site 762570000256 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 762570000257 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 762570000258 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 762570000259 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 762570000260 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 762570000261 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 762570000262 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 762570000263 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762570000264 active site 762570000265 catalytic tetrad [active] 762570000266 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762570000267 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 762570000268 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762570000269 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762570000270 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 762570000271 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762570000272 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 762570000273 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762570000274 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 762570000275 substrate binding site [chemical binding]; other site 762570000276 oxyanion hole (OAH) forming residues; other site 762570000277 trimer interface [polypeptide binding]; other site 762570000278 Domain of unknown function DUF21; Region: DUF21; pfam01595 762570000279 FOG: CBS domain [General function prediction only]; Region: COG0517 762570000280 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762570000281 Transporter associated domain; Region: CorC_HlyC; smart01091 762570000282 Uncharacterized conserved protein [Function unknown]; Region: COG2128 762570000283 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 762570000284 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 762570000285 active site 762570000286 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 762570000287 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570000288 citrate synthase; Provisional; Region: PRK14033 762570000289 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 762570000290 oxalacetate binding site [chemical binding]; other site 762570000291 citrylCoA binding site [chemical binding]; other site 762570000292 coenzyme A binding site [chemical binding]; other site 762570000293 catalytic triad [active] 762570000294 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 762570000295 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762570000296 tetramer interface [polypeptide binding]; other site 762570000297 active site 762570000298 Mg2+/Mn2+ binding site [ion binding]; other site 762570000299 AAA domain; Region: AAA_26; pfam13500 762570000300 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 762570000301 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762570000302 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 762570000303 inhibitor-cofactor binding pocket; inhibition site 762570000304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570000305 catalytic residue [active] 762570000306 hypothetical protein; Validated; Region: PRK06840 762570000307 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 762570000308 dimer interface [polypeptide binding]; other site 762570000309 active site 762570000310 CoA binding pocket [chemical binding]; other site 762570000311 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 762570000312 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 762570000313 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762570000314 catalytic residue [active] 762570000315 biotin synthase; Region: bioB; TIGR00433 762570000316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762570000317 FeS/SAM binding site; other site 762570000318 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 762570000319 HTH domain; Region: HTH_11; cl17392 762570000320 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 762570000321 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 762570000322 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 762570000323 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 762570000324 active site 762570000325 catalytic residues [active] 762570000326 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 762570000327 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762570000328 nucleotide binding site [chemical binding]; other site 762570000329 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 762570000330 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 762570000331 active site 762570000332 Zn binding site [ion binding]; other site 762570000333 FOG: CBS domain [General function prediction only]; Region: COG0517 762570000334 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 762570000335 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 762570000336 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 762570000337 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 762570000338 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 762570000339 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 762570000340 potential catalytic triad [active] 762570000341 conserved cys residue [active] 762570000342 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 762570000343 DNA-binding site [nucleotide binding]; DNA binding site 762570000344 RNA-binding motif; other site 762570000345 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 762570000346 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 762570000347 Trehalase; Region: Trehalase; cl17346 762570000348 trehalase; Provisional; Region: treF; PRK13270 762570000349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762570000350 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 762570000351 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 762570000352 putative NAD(P) binding site [chemical binding]; other site 762570000353 putative substrate binding site [chemical binding]; other site 762570000354 catalytic Zn binding site [ion binding]; other site 762570000355 structural Zn binding site [ion binding]; other site 762570000356 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 762570000357 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762570000358 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 762570000359 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 762570000360 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 762570000361 protein binding site [polypeptide binding]; other site 762570000362 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 762570000363 Catalytic dyad [active] 762570000364 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 762570000365 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762570000366 active site 762570000367 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 762570000368 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 762570000369 dimer interface [polypeptide binding]; other site 762570000370 active site 762570000371 glycine-pyridoxal phosphate binding site [chemical binding]; other site 762570000372 folate binding site [chemical binding]; other site 762570000373 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 762570000374 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 762570000375 Uncharacterized conserved protein [Function unknown]; Region: COG3342 762570000376 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 762570000377 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 762570000378 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 762570000379 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 762570000380 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 762570000381 NAD binding site [chemical binding]; other site 762570000382 dimer interface [polypeptide binding]; other site 762570000383 substrate binding site [chemical binding]; other site 762570000384 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762570000385 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 762570000386 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 762570000387 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762570000388 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 762570000389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762570000390 FeS/SAM binding site; other site 762570000391 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 762570000392 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 762570000393 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 762570000394 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 762570000395 TrkA-N domain; Region: TrkA_N; pfam02254 762570000396 TrkA-C domain; Region: TrkA_C; pfam02080 762570000397 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 762570000398 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570000399 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 762570000400 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 762570000401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570000402 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 762570000403 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570000404 DNA binding residues [nucleotide binding] 762570000405 GH3 auxin-responsive promoter; Region: GH3; pfam03321 762570000406 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 762570000407 dihydropteroate synthase; Region: DHPS; TIGR01496 762570000408 substrate binding pocket [chemical binding]; other site 762570000409 dimer interface [polypeptide binding]; other site 762570000410 inhibitor binding site; inhibition site 762570000411 Uncharacterized conserved protein [Function unknown]; Region: COG1624 762570000412 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 762570000413 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 762570000414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762570000415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762570000416 S-adenosylmethionine binding site [chemical binding]; other site 762570000417 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 762570000418 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 762570000419 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 762570000420 shikimate binding site; other site 762570000421 NAD(P) binding site [chemical binding]; other site 762570000422 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 762570000423 Putative transcription activator [Transcription]; Region: TenA; COG0819 762570000424 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 762570000425 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 762570000426 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762570000427 ligand binding site [chemical binding]; other site 762570000428 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 762570000429 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 762570000430 putative NAD(P) binding site [chemical binding]; other site 762570000431 homodimer interface [polypeptide binding]; other site 762570000432 homotetramer interface [polypeptide binding]; other site 762570000433 active site 762570000434 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 762570000435 Domain of unknown function (DUF368); Region: DUF368; pfam04018 762570000436 TPR repeat; Region: TPR_11; pfam13414 762570000437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570000438 binding surface 762570000439 TPR motif; other site 762570000440 TPR repeat; Region: TPR_11; pfam13414 762570000441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570000442 binding surface 762570000443 TPR motif; other site 762570000444 TPR repeat; Region: TPR_11; pfam13414 762570000445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570000446 binding surface 762570000447 TPR repeat; Region: TPR_11; pfam13414 762570000448 TPR motif; other site 762570000449 Tetratricopeptide repeat; Region: TPR_12; pfam13424 762570000450 TPR repeat; Region: TPR_11; pfam13414 762570000451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570000452 binding surface 762570000453 TPR motif; other site 762570000454 Tetratricopeptide repeat; Region: TPR_16; pfam13432 762570000455 thymidylate kinase; Validated; Region: tmk; PRK00698 762570000456 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 762570000457 TMP-binding site; other site 762570000458 ATP-binding site [chemical binding]; other site 762570000459 ferric uptake regulator; Provisional; Region: fur; PRK09462 762570000460 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 762570000461 metal binding site 2 [ion binding]; metal-binding site 762570000462 putative DNA binding helix; other site 762570000463 metal binding site 1 [ion binding]; metal-binding site 762570000464 dimer interface [polypeptide binding]; other site 762570000465 structural Zn2+ binding site [ion binding]; other site 762570000466 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 762570000467 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762570000468 active site 762570000469 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 762570000470 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 762570000471 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 762570000472 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 762570000473 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 762570000474 dimerization interface [polypeptide binding]; other site 762570000475 ATP binding site [chemical binding]; other site 762570000476 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 762570000477 dimerization interface [polypeptide binding]; other site 762570000478 ATP binding site [chemical binding]; other site 762570000479 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762570000480 catalytic residues [active] 762570000481 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 762570000482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762570000483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762570000484 BON domain; Region: BON; pfam04972 762570000485 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762570000486 Proline dehydrogenase; Region: Pro_dh; cl03282 762570000487 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 762570000488 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762570000489 homodimer interface [polypeptide binding]; other site 762570000490 substrate-cofactor binding pocket; other site 762570000491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570000492 catalytic residue [active] 762570000493 PAS domain S-box; Region: sensory_box; TIGR00229 762570000494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570000495 putative active site [active] 762570000496 heme pocket [chemical binding]; other site 762570000497 PAS domain S-box; Region: sensory_box; TIGR00229 762570000498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570000499 putative active site [active] 762570000500 heme pocket [chemical binding]; other site 762570000501 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 762570000502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570000503 putative active site [active] 762570000504 heme pocket [chemical binding]; other site 762570000505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570000506 dimer interface [polypeptide binding]; other site 762570000507 phosphorylation site [posttranslational modification] 762570000508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570000509 ATP binding site [chemical binding]; other site 762570000510 Mg2+ binding site [ion binding]; other site 762570000511 G-X-G motif; other site 762570000512 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 762570000513 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 762570000514 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 762570000515 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 762570000516 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 762570000517 active site residue [active] 762570000518 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 762570000519 active site residue [active] 762570000520 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 762570000521 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 762570000522 CoA-binding site [chemical binding]; other site 762570000523 ATP-binding [chemical binding]; other site 762570000524 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 762570000525 nucleotide binding site/active site [active] 762570000526 HIT family signature motif; other site 762570000527 catalytic residue [active] 762570000528 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 762570000529 active site 762570000530 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 762570000531 homodecamer interface [polypeptide binding]; other site 762570000532 GTP cyclohydrolase I; Provisional; Region: PLN03044 762570000533 active site 762570000534 putative catalytic site residues [active] 762570000535 zinc binding site [ion binding]; other site 762570000536 GTP-CH-I/GFRP interaction surface; other site 762570000537 short chain dehydrogenase; Provisional; Region: PRK07454 762570000538 classical (c) SDRs; Region: SDR_c; cd05233 762570000539 NAD(P) binding site [chemical binding]; other site 762570000540 active site 762570000541 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 762570000542 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 762570000543 active site 762570000544 PAS fold; Region: PAS_4; pfam08448 762570000545 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570000546 putative active site [active] 762570000547 PAS fold; Region: PAS; pfam00989 762570000548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570000549 putative active site [active] 762570000550 heme pocket [chemical binding]; other site 762570000551 hypothetical protein; Validated; Region: PRK00228 762570000552 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762570000553 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762570000554 active site 762570000555 catalytic tetrad [active] 762570000556 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 762570000557 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570000558 type III secretion system chaperone YscW; Region: YscW; TIGR02567 762570000559 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 762570000560 Dehydroquinase class II; Region: DHquinase_II; pfam01220 762570000561 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 762570000562 active site 762570000563 trimer interface [polypeptide binding]; other site 762570000564 dimer interface [polypeptide binding]; other site 762570000565 putative hydrolase; Provisional; Region: PRK02113 762570000566 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 762570000567 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 762570000568 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762570000569 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 762570000570 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 762570000571 putative Iron-sulfur protein interface [polypeptide binding]; other site 762570000572 putative proximal heme binding site [chemical binding]; other site 762570000573 putative SdhD-like interface [polypeptide binding]; other site 762570000574 putative distal heme binding site [chemical binding]; other site 762570000575 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 762570000576 putative Iron-sulfur protein interface [polypeptide binding]; other site 762570000577 putative proximal heme binding site [chemical binding]; other site 762570000578 putative SdhC-like subunit interface [polypeptide binding]; other site 762570000579 putative distal heme binding site [chemical binding]; other site 762570000580 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 762570000581 L-aspartate oxidase; Provisional; Region: PRK06175 762570000582 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 762570000583 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 762570000584 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762570000585 catalytic loop [active] 762570000586 iron binding site [ion binding]; other site 762570000587 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 762570000588 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 762570000589 putative active site pocket [active] 762570000590 dimerization interface [polypeptide binding]; other site 762570000591 putative catalytic residue [active] 762570000592 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 762570000593 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762570000594 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762570000595 catalytic residue [active] 762570000596 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762570000597 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 762570000598 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762570000599 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762570000600 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762570000601 nicotinate-nucleotide diphosphorylase (carboxylating); Region: PLN02716 762570000602 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 762570000603 dimerization interface [polypeptide binding]; other site 762570000604 active site 762570000605 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 762570000606 active site 762570000607 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 762570000608 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 762570000609 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 762570000610 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 762570000611 Probable Catalytic site; other site 762570000612 metal-binding site 762570000613 CoA-binding domain; Region: CoA_binding_3; pfam13727 762570000614 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 762570000615 heme-binding residues [chemical binding]; other site 762570000616 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762570000617 molybdopterin cofactor binding site; other site 762570000618 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 762570000619 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 762570000620 4Fe-4S binding domain; Region: Fer4; cl02805 762570000621 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 762570000622 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 762570000623 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 762570000624 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 762570000625 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 762570000626 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 762570000627 Cu(I) binding site [ion binding]; other site 762570000628 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 762570000629 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 762570000630 Cytochrome c; Region: Cytochrom_C; pfam00034 762570000631 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 762570000632 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 762570000633 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 762570000634 Subunit I/III interface [polypeptide binding]; other site 762570000635 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 762570000636 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 762570000637 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 762570000638 FAD binding site [chemical binding]; other site 762570000639 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 762570000640 DNA-binding site [nucleotide binding]; DNA binding site 762570000641 RNA-binding motif; other site 762570000642 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 762570000643 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 762570000644 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 762570000645 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 762570000646 putative active site [active] 762570000647 Predicted methyltransferases [General function prediction only]; Region: COG0313 762570000648 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 762570000649 putative SAM binding site [chemical binding]; other site 762570000650 putative homodimer interface [polypeptide binding]; other site 762570000651 Predicted permeases [General function prediction only]; Region: COG0795 762570000652 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 762570000653 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 762570000654 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 762570000655 phosphodiesterase YaeI; Provisional; Region: PRK11340 762570000656 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 762570000657 putative active site [active] 762570000658 putative metal binding site [ion binding]; other site 762570000659 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 762570000660 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 762570000661 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 762570000662 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 762570000663 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 762570000664 putative catalytic site [active] 762570000665 putative phosphate binding site [ion binding]; other site 762570000666 putative metal binding site [ion binding]; other site 762570000667 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 762570000668 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570000669 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570000670 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 762570000671 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 762570000672 ligand binding site [chemical binding]; other site 762570000673 NAD binding site [chemical binding]; other site 762570000674 catalytic site [active] 762570000675 homodimer interface [polypeptide binding]; other site 762570000676 GTPase Era; Reviewed; Region: era; PRK00089 762570000677 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 762570000678 G1 box; other site 762570000679 GTP/Mg2+ binding site [chemical binding]; other site 762570000680 Switch I region; other site 762570000681 G2 box; other site 762570000682 Switch II region; other site 762570000683 G3 box; other site 762570000684 G4 box; other site 762570000685 G5 box; other site 762570000686 KH domain; Region: KH_2; pfam07650 762570000687 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 762570000688 active site 762570000689 hydrophilic channel; other site 762570000690 dimerization interface [polypeptide binding]; other site 762570000691 catalytic residues [active] 762570000692 active site lid [active] 762570000693 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 762570000694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570000695 S-adenosylmethionine binding site [chemical binding]; other site 762570000696 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 762570000697 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 762570000698 active site 762570000699 (T/H)XGH motif; other site 762570000700 aspartate aminotransferase; Provisional; Region: PRK05764 762570000701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762570000702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570000703 homodimer interface [polypeptide binding]; other site 762570000704 catalytic residue [active] 762570000705 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 762570000706 Peptidase family M50; Region: Peptidase_M50; pfam02163 762570000707 active site 762570000708 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 762570000709 putative substrate binding region [chemical binding]; other site 762570000710 BNR repeat-like domain; Region: BNR_2; pfam13088 762570000711 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 762570000712 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762570000713 active site residue [active] 762570000714 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762570000715 active site residue [active] 762570000716 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 762570000717 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762570000718 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762570000719 catalytic residues [active] 762570000720 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762570000721 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 762570000722 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 762570000723 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762570000724 active site residue [active] 762570000725 Sulphur transport; Region: Sulf_transp; pfam04143 762570000726 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762570000727 dimerization interface [polypeptide binding]; other site 762570000728 putative DNA binding site [nucleotide binding]; other site 762570000729 putative Zn2+ binding site [ion binding]; other site 762570000730 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 762570000731 active site 762570000732 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 762570000733 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762570000734 active site 762570000735 metal binding site [ion binding]; metal-binding site 762570000736 DNA binding site [nucleotide binding] 762570000737 Transglycosylase; Region: Transgly; pfam00912 762570000738 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 762570000739 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762570000740 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 762570000741 putative active site [active] 762570000742 putative metal binding site [ion binding]; other site 762570000743 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 762570000744 Rhomboid family; Region: Rhomboid; pfam01694 762570000745 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 762570000746 GcpE protein; Region: GcpE; pfam04551 762570000747 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 762570000748 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762570000749 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762570000750 DNA binding site [nucleotide binding] 762570000751 domain linker motif; other site 762570000752 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762570000753 dimerization interface [polypeptide binding]; other site 762570000754 ligand binding site [chemical binding]; other site 762570000755 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 762570000756 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 762570000757 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 762570000758 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 762570000759 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570000760 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762570000761 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570000762 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570000763 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570000764 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 762570000765 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 762570000766 active site 762570000767 catalytic site [active] 762570000768 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570000769 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 762570000770 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 762570000771 active site 762570000772 homodimer interface [polypeptide binding]; other site 762570000773 catalytic site [active] 762570000774 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 762570000775 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 762570000776 GAF domain; Region: GAF; cl17456 762570000777 GAF domain; Region: GAF; cl17456 762570000778 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 762570000779 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 762570000780 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 762570000781 active site 762570000782 metal binding site [ion binding]; metal-binding site 762570000783 homotetramer interface [polypeptide binding]; other site 762570000784 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 762570000785 metal-dependent hydrolase; Provisional; Region: PRK00685 762570000786 Protein of unknown function (DUF433); Region: DUF433; pfam04255 762570000787 Predicted membrane protein [Function unknown]; Region: COG1297 762570000788 putative oligopeptide transporter, OPT family; Region: TIGR00733 762570000789 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 762570000790 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570000791 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 762570000792 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 762570000793 dimerization interface [polypeptide binding]; other site 762570000794 allosteric effector site; other site 762570000795 active site 762570000796 ADP/pyrophosphate binding site [chemical binding]; other site 762570000797 fructose-1,6-bisphosphate binding site; other site 762570000798 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 762570000799 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 762570000800 putative NAD(P) binding site [chemical binding]; other site 762570000801 active site 762570000802 Rossmann-like domain; Region: Rossmann-like; pfam10727 762570000803 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 762570000804 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 762570000805 active site 762570000806 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 762570000807 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 762570000808 dimer interface [polypeptide binding]; other site 762570000809 putative anticodon binding site; other site 762570000810 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 762570000811 motif 1; other site 762570000812 active site 762570000813 motif 2; other site 762570000814 motif 3; other site 762570000815 H+ Antiporter protein; Region: 2A0121; TIGR00900 762570000816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762570000817 putative substrate translocation pore; other site 762570000818 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 762570000819 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 762570000820 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 762570000821 FOG: PKD repeat [General function prediction only]; Region: COG3291 762570000822 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 762570000823 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 762570000824 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762570000825 ligand binding site [chemical binding]; other site 762570000826 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 762570000827 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 762570000828 Peptidase family M23; Region: Peptidase_M23; pfam01551 762570000829 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 762570000830 ATP synthase A chain; Region: ATP-synt_A; cl00413 762570000831 ATP synthase subunit C; Region: ATP-synt_C; cl00466 762570000832 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 762570000833 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 762570000834 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 762570000835 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 762570000836 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 762570000837 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762570000838 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 762570000839 beta subunit interaction interface [polypeptide binding]; other site 762570000840 Walker A motif; other site 762570000841 ATP binding site [chemical binding]; other site 762570000842 Walker B motif; other site 762570000843 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 762570000844 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 762570000845 core domain interface [polypeptide binding]; other site 762570000846 delta subunit interface [polypeptide binding]; other site 762570000847 epsilon subunit interface [polypeptide binding]; other site 762570000848 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 762570000849 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 762570000850 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 762570000851 Part of AAA domain; Region: AAA_19; pfam13245 762570000852 Family description; Region: UvrD_C_2; pfam13538 762570000853 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 762570000854 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 762570000855 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762570000856 FeS/SAM binding site; other site 762570000857 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 762570000858 Ligand Binding Site [chemical binding]; other site 762570000859 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 762570000860 active site 762570000861 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 762570000862 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 762570000863 Dynamin family; Region: Dynamin_N; pfam00350 762570000864 G1 box; other site 762570000865 GTP/Mg2+ binding site [chemical binding]; other site 762570000866 G2 box; other site 762570000867 Switch I region; other site 762570000868 G3 box; other site 762570000869 Switch II region; other site 762570000870 G4 box; other site 762570000871 G5 box; other site 762570000872 recombination factor protein RarA; Reviewed; Region: PRK13342 762570000873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570000874 Walker A motif; other site 762570000875 ATP binding site [chemical binding]; other site 762570000876 Walker B motif; other site 762570000877 arginine finger; other site 762570000878 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 762570000879 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 762570000880 6-phosphogluconate dehydratase; Region: edd; TIGR01196 762570000881 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 762570000882 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 762570000883 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 762570000884 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762570000885 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762570000886 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570000887 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762570000888 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570000889 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570000890 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570000891 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570000892 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762570000893 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570000894 Uncharacterized protein family (UPF0164); Region: UPF0164; pfam03687 762570000895 NHL repeat; Region: NHL; pfam01436 762570000896 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 762570000897 putative catalytic site [active] 762570000898 putative metal binding site [ion binding]; other site 762570000899 putative phosphate binding site [ion binding]; other site 762570000900 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570000901 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 762570000902 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 762570000903 active site 762570000904 dimer interface [polypeptide binding]; other site 762570000905 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 762570000906 intracellular protease, PfpI family; Region: PfpI; TIGR01382 762570000907 conserved cys residue [active] 762570000908 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 762570000909 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 762570000910 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762570000911 FeS/SAM binding site; other site 762570000912 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 762570000913 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 762570000914 TPP-binding site [chemical binding]; other site 762570000915 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 762570000916 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 762570000917 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 762570000918 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 762570000919 dimer interface [polypeptide binding]; other site 762570000920 PYR/PP interface [polypeptide binding]; other site 762570000921 TPP binding site [chemical binding]; other site 762570000922 substrate binding site [chemical binding]; other site 762570000923 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762570000924 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 762570000925 thymidylate synthase; Reviewed; Region: thyA; PRK01827 762570000926 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 762570000927 dimerization interface [polypeptide binding]; other site 762570000928 active site 762570000929 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 762570000930 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 762570000931 putative active site [active] 762570000932 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 762570000933 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 762570000934 folate binding site [chemical binding]; other site 762570000935 NADP+ binding site [chemical binding]; other site 762570000936 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 762570000937 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 762570000938 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 762570000939 protein-splicing catalytic site; other site 762570000940 thioester formation/cholesterol transfer; other site 762570000941 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 762570000942 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 762570000943 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 762570000944 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 762570000945 Two component regulator propeller; Region: Reg_prop; pfam07494 762570000946 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 762570000947 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 762570000948 dimerization interface [polypeptide binding]; other site 762570000949 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762570000950 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762570000951 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762570000952 dimer interface [polypeptide binding]; other site 762570000953 putative CheW interface [polypeptide binding]; other site 762570000954 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 762570000955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570000956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570000957 DNA binding residues [nucleotide binding] 762570000958 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570000959 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 762570000960 amidohydrolase; Region: amidohydrolases; TIGR01891 762570000961 putative metal binding site [ion binding]; other site 762570000962 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 762570000963 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 762570000964 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 762570000965 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762570000966 putative active site [active] 762570000967 putative metal binding site [ion binding]; other site 762570000968 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762570000969 EamA-like transporter family; Region: EamA; pfam00892 762570000970 EamA-like transporter family; Region: EamA; pfam00892 762570000971 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762570000972 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762570000973 DNA binding site [nucleotide binding] 762570000974 domain linker motif; other site 762570000975 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762570000976 dimerization interface [polypeptide binding]; other site 762570000977 ligand binding site [chemical binding]; other site 762570000978 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 762570000979 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 762570000980 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570000981 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570000982 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 762570000983 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570000984 Uncharacterized protein family (UPF0164); Region: UPF0164; pfam03687 762570000985 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 762570000986 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 762570000987 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 762570000988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762570000989 dimer interface [polypeptide binding]; other site 762570000990 conserved gate region; other site 762570000991 putative PBP binding loops; other site 762570000992 ABC-ATPase subunit interface; other site 762570000993 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 762570000994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762570000995 dimer interface [polypeptide binding]; other site 762570000996 conserved gate region; other site 762570000997 ABC-ATPase subunit interface; other site 762570000998 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 762570000999 active site 762570001000 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 762570001001 active site 762570001002 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 762570001003 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 762570001004 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 762570001005 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 762570001006 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 762570001007 Walker A/P-loop; other site 762570001008 ATP binding site [chemical binding]; other site 762570001009 Q-loop/lid; other site 762570001010 ABC transporter signature motif; other site 762570001011 Walker B; other site 762570001012 D-loop; other site 762570001013 H-loop/switch region; other site 762570001014 TOBE domain; Region: TOBE_2; pfam08402 762570001015 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 762570001016 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 762570001017 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 762570001018 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 762570001019 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 762570001020 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 762570001021 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762570001022 nucleotide binding region [chemical binding]; other site 762570001023 ATP-binding site [chemical binding]; other site 762570001024 SEC-C motif; Region: SEC-C; pfam02810 762570001025 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 762570001026 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 762570001027 Walker A/P-loop; other site 762570001028 ATP binding site [chemical binding]; other site 762570001029 Q-loop/lid; other site 762570001030 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 762570001031 ABC transporter signature motif; other site 762570001032 Walker B; other site 762570001033 D-loop; other site 762570001034 H-loop/switch region; other site 762570001035 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 762570001036 GAF domain; Region: GAF_2; pfam13185 762570001037 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 762570001038 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 762570001039 active site 762570001040 substrate binding site [chemical binding]; other site 762570001041 metal binding site [ion binding]; metal-binding site 762570001042 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 762570001043 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 762570001044 Low molecular weight phosphatase family; Region: LMWPc; cd00115 762570001045 active site 762570001046 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 762570001047 dimerization interface [polypeptide binding]; other site 762570001048 putative active site pocket [active] 762570001049 putative catalytic residue [active] 762570001050 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762570001051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762570001052 Coenzyme A binding pocket [chemical binding]; other site 762570001053 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 762570001054 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 762570001055 metal binding site [ion binding]; metal-binding site 762570001056 dimer interface [polypeptide binding]; other site 762570001057 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762570001058 Protein of unknown function (DUF328); Region: DUF328; pfam03883 762570001059 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 762570001060 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 762570001061 ATP-binding site [chemical binding]; other site 762570001062 Sugar specificity; other site 762570001063 Pyrimidine base specificity; other site 762570001064 Type III pantothenate kinase; Region: Pan_kinase; cl17198 762570001065 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 762570001066 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 762570001067 active site 762570001068 dimerization interface [polypeptide binding]; other site 762570001069 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 762570001070 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 762570001071 NAD binding site [chemical binding]; other site 762570001072 homotetramer interface [polypeptide binding]; other site 762570001073 homodimer interface [polypeptide binding]; other site 762570001074 substrate binding site [chemical binding]; other site 762570001075 active site 762570001076 Peptidase family M1; Region: Peptidase_M1; pfam01433 762570001077 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 762570001078 Zn binding site [ion binding]; other site 762570001079 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 762570001080 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 762570001081 Src Homology 3 domain superfamily; Region: SH3; cl17036 762570001082 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 762570001083 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 762570001084 Methyltransferase domain; Region: Methyltransf_23; pfam13489 762570001085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570001086 S-adenosylmethionine binding site [chemical binding]; other site 762570001087 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 762570001088 dimer interface [polypeptide binding]; other site 762570001089 active site residues [active] 762570001090 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 762570001091 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 762570001092 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 762570001093 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 762570001094 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 762570001095 Nucleoside recognition; Region: Gate; pfam07670 762570001096 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 762570001097 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 762570001098 Zn binding site [ion binding]; other site 762570001099 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 762570001100 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762570001101 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 762570001102 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 762570001103 Part of AAA domain; Region: AAA_19; pfam13245 762570001104 Family description; Region: UvrD_C_2; pfam13538 762570001105 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 762570001106 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 762570001107 hypothetical protein; Provisional; Region: PRK11770 762570001108 Domain of unknown function (DUF307); Region: DUF307; pfam03733 762570001109 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 762570001110 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 762570001111 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 762570001112 FMN binding site [chemical binding]; other site 762570001113 active site 762570001114 catalytic residues [active] 762570001115 substrate binding site [chemical binding]; other site 762570001116 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 762570001117 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762570001118 active site 762570001119 DNA binding site [nucleotide binding] 762570001120 Int/Topo IB signature motif; other site 762570001121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570001122 S-adenosylmethionine binding site [chemical binding]; other site 762570001123 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 762570001124 Recombination protein O N terminal; Region: RecO_N; pfam11967 762570001125 Recombination protein O C terminal; Region: RecO_C; pfam02565 762570001126 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 762570001127 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 762570001128 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762570001129 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762570001130 Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928 762570001131 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 762570001132 nudix motif; other site 762570001133 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 762570001134 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 762570001135 [4Fe-4S] binding site [ion binding]; other site 762570001136 molybdopterin cofactor binding site; other site 762570001137 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 762570001138 molybdopterin cofactor binding site; other site 762570001139 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 762570001140 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762570001141 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762570001142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762570001143 Walker A/P-loop; other site 762570001144 ATP binding site [chemical binding]; other site 762570001145 Q-loop/lid; other site 762570001146 ABC transporter signature motif; other site 762570001147 Walker B; other site 762570001148 D-loop; other site 762570001149 H-loop/switch region; other site 762570001150 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762570001151 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762570001152 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762570001153 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 762570001154 Walker A/P-loop; other site 762570001155 ATP binding site [chemical binding]; other site 762570001156 Q-loop/lid; other site 762570001157 ABC transporter signature motif; other site 762570001158 Walker B; other site 762570001159 D-loop; other site 762570001160 H-loop/switch region; other site 762570001161 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762570001162 putative DNA binding site [nucleotide binding]; other site 762570001163 dimerization interface [polypeptide binding]; other site 762570001164 putative Zn2+ binding site [ion binding]; other site 762570001165 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 762570001166 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762570001167 active site 762570001168 metal binding site [ion binding]; metal-binding site 762570001169 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 762570001170 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 762570001171 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 762570001172 Metal-binding active site; metal-binding site 762570001173 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 762570001174 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 762570001175 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 762570001176 active site 762570001177 phosphorylation site [posttranslational modification] 762570001178 TrkA-C domain; Region: TrkA_C; pfam02080 762570001179 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570001180 active site 762570001181 NTP binding site [chemical binding]; other site 762570001182 metal binding triad [ion binding]; metal-binding site 762570001183 antibiotic binding site [chemical binding]; other site 762570001184 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 762570001185 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 762570001186 THF binding site; other site 762570001187 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 762570001188 substrate binding site [chemical binding]; other site 762570001189 THF binding site; other site 762570001190 zinc-binding site [ion binding]; other site 762570001191 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 762570001192 dimer interface [polypeptide binding]; other site 762570001193 putative radical transfer pathway; other site 762570001194 diiron center [ion binding]; other site 762570001195 tyrosyl radical; other site 762570001196 ATP cone domain; Region: ATP-cone; pfam03477 762570001197 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 762570001198 ATP cone domain; Region: ATP-cone; pfam03477 762570001199 Class I ribonucleotide reductase; Region: RNR_I; cd01679 762570001200 active site 762570001201 dimer interface [polypeptide binding]; other site 762570001202 catalytic residues [active] 762570001203 effector binding site; other site 762570001204 R2 peptide binding site; other site 762570001205 YceI-like domain; Region: YceI; pfam04264 762570001206 YceI-like domain; Region: YceI; pfam04264 762570001207 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 762570001208 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 762570001209 nucleotide binding site [chemical binding]; other site 762570001210 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 762570001211 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 762570001212 Oxygen tolerance; Region: BatD; pfam13584 762570001213 von Willebrand factor type A domain; Region: VWA_2; pfam13519 762570001214 metal ion-dependent adhesion site (MIDAS); other site 762570001215 Aerotolerance regulator N-terminal; Region: BatA; cl06567 762570001216 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 762570001217 metal ion-dependent adhesion site (MIDAS); other site 762570001218 Protein of unknown function (DUF493); Region: DUF493; pfam04359 762570001219 Response regulator receiver domain; Region: Response_reg; pfam00072 762570001220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 762570001221 active site 762570001222 phosphorylation site [posttranslational modification] 762570001223 intermolecular recognition site; other site 762570001224 dimerization interface [polypeptide binding]; other site 762570001225 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 762570001226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762570001227 motif II; other site 762570001228 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 762570001229 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 762570001230 substrate-cofactor binding pocket; other site 762570001231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570001232 catalytic residue [active] 762570001233 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 762570001234 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762570001235 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 762570001236 ParB-like nuclease domain; Region: ParBc; pfam02195 762570001237 KorB domain; Region: KorB; pfam08535 762570001238 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 762570001239 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762570001240 P-loop; other site 762570001241 Magnesium ion binding site [ion binding]; other site 762570001242 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762570001243 Magnesium ion binding site [ion binding]; other site 762570001244 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 762570001245 Part of AAA domain; Region: AAA_19; pfam13245 762570001246 Family description; Region: UvrD_C_2; pfam13538 762570001247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762570001248 Coenzyme A binding pocket [chemical binding]; other site 762570001249 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 762570001250 DinB superfamily; Region: DinB_2; pfam12867 762570001251 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762570001252 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 762570001253 FtsX-like permease family; Region: FtsX; pfam02687 762570001254 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762570001255 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 762570001256 FtsX-like permease family; Region: FtsX; pfam02687 762570001257 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 762570001258 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762570001259 active site 762570001260 dimer interface [polypeptide binding]; other site 762570001261 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 762570001262 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 762570001263 putative carbohydrate kinase; Provisional; Region: PRK10565 762570001264 Uncharacterized conserved protein [Function unknown]; Region: COG0062 762570001265 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 762570001266 putative substrate binding site [chemical binding]; other site 762570001267 putative ATP binding site [chemical binding]; other site 762570001268 Bacterial Ig-like domain; Region: Big_5; pfam13205 762570001269 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570001270 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 762570001271 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 762570001272 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 762570001273 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 762570001274 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 762570001275 hexamer interface [polypeptide binding]; other site 762570001276 ligand binding site [chemical binding]; other site 762570001277 putative active site [active] 762570001278 NAD(P) binding site [chemical binding]; other site 762570001279 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762570001280 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762570001281 DNA binding site [nucleotide binding] 762570001282 domain linker motif; other site 762570001283 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762570001284 ligand binding site [chemical binding]; other site 762570001285 dimerization interface [polypeptide binding]; other site 762570001286 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 762570001287 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 762570001288 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 762570001289 hexamer (dimer of trimers) interface [polypeptide binding]; other site 762570001290 substrate binding site [chemical binding]; other site 762570001291 trimer interface [polypeptide binding]; other site 762570001292 Mn binding site [ion binding]; other site 762570001293 ribulokinase; Provisional; Region: PRK04123 762570001294 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 762570001295 N- and C-terminal domain interface [polypeptide binding]; other site 762570001296 active site 762570001297 MgATP binding site [chemical binding]; other site 762570001298 catalytic site [active] 762570001299 metal binding site [ion binding]; metal-binding site 762570001300 carbohydrate binding site [chemical binding]; other site 762570001301 homodimer interface [polypeptide binding]; other site 762570001302 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 762570001303 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 762570001304 intersubunit interface [polypeptide binding]; other site 762570001305 active site 762570001306 Zn2+ binding site [ion binding]; other site 762570001307 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 762570001308 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 762570001309 Na binding site [ion binding]; other site 762570001310 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 762570001311 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 762570001312 TPP-binding site [chemical binding]; other site 762570001313 dimer interface [polypeptide binding]; other site 762570001314 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 762570001315 PYR/PP interface [polypeptide binding]; other site 762570001316 dimer interface [polypeptide binding]; other site 762570001317 TPP binding site [chemical binding]; other site 762570001318 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762570001319 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 762570001320 active site 762570001321 intersubunit interactions; other site 762570001322 catalytic residue [active] 762570001323 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 762570001324 active site 762570001325 catalytic residues [active] 762570001326 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 762570001327 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 762570001328 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 762570001329 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762570001330 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762570001331 DNA binding site [nucleotide binding] 762570001332 domain linker motif; other site 762570001333 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762570001334 dimerization interface [polypeptide binding]; other site 762570001335 ligand binding site [chemical binding]; other site 762570001336 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 762570001337 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570001338 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 762570001339 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 762570001340 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570001341 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 762570001342 starch binding outer membrane protein SusD; Region: SusD; cd08977 762570001343 SusD family; Region: SusD; pfam07980 762570001344 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 762570001345 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 762570001346 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 762570001347 substrate binding site [chemical binding]; other site 762570001348 active site 762570001349 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 762570001350 substrate binding site [chemical binding]; other site 762570001351 active site 762570001352 Family description; Region: VCBS; pfam13517 762570001353 Family description; Region: VCBS; pfam13517 762570001354 Family description; Region: VCBS; pfam13517 762570001355 Family description; Region: VCBS; pfam13517 762570001356 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 762570001357 Family description; Region: VCBS; pfam13517 762570001358 Family description; Region: VCBS; pfam13517 762570001359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 762570001360 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 762570001361 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 762570001362 active site 762570001363 catalytic site [active] 762570001364 substrate binding site [chemical binding]; other site 762570001365 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 762570001366 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 762570001367 DinB family; Region: DinB; cl17821 762570001368 DinB superfamily; Region: DinB_2; pfam12867 762570001369 galactokinase; Region: gal_kin; TIGR00131 762570001370 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 762570001371 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 762570001372 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 762570001373 putative transporter; Provisional; Region: PRK10484 762570001374 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 762570001375 Na binding site [ion binding]; other site 762570001376 substrate binding site [chemical binding]; other site 762570001377 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 762570001378 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 762570001379 dimer interface [polypeptide binding]; other site 762570001380 active site 762570001381 Protein of unknown function, DUF486; Region: DUF486; cl01236 762570001382 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762570001383 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 762570001384 inhibitor site; inhibition site 762570001385 active site 762570001386 dimer interface [polypeptide binding]; other site 762570001387 catalytic residue [active] 762570001388 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 762570001389 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762570001390 NAD(P) binding site [chemical binding]; other site 762570001391 catalytic residues [active] 762570001392 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762570001393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762570001394 DNA-binding site [nucleotide binding]; DNA binding site 762570001395 FCD domain; Region: FCD; pfam07729 762570001396 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 762570001397 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 762570001398 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 762570001399 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 762570001400 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 762570001401 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 762570001402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762570001403 motif II; other site 762570001404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 762570001405 mannosyl-3-phosphoglycerate synthase; Provisional; Region: PRK14503 762570001406 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth); Region: Osmo_MPGsynth; pfam09488 762570001407 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 762570001408 Trehalase; Region: Trehalase; cl17346 762570001409 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 762570001410 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 762570001411 protein-splicing catalytic site; other site 762570001412 thioester formation/cholesterol transfer; other site 762570001413 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 762570001414 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 762570001415 protein-splicing catalytic site; other site 762570001416 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 762570001417 Kelch motif; Region: Kelch_1; pfam01344 762570001418 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 762570001419 Kelch motif; Region: Kelch_1; pfam01344 762570001420 Kelch motif; Region: Kelch_1; pfam01344 762570001421 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 762570001422 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 762570001423 Catalytic domain of Protein Kinases; Region: PKc; cd00180 762570001424 active site 762570001425 ATP binding site [chemical binding]; other site 762570001426 substrate binding site [chemical binding]; other site 762570001427 activation loop (A-loop); other site 762570001428 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 762570001429 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 762570001430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570001431 Walker A motif; other site 762570001432 ATP binding site [chemical binding]; other site 762570001433 Walker B motif; other site 762570001434 arginine finger; other site 762570001435 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762570001436 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570001437 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 762570001438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762570001439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570001440 dimer interface [polypeptide binding]; other site 762570001441 phosphorylation site [posttranslational modification] 762570001442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570001443 ATP binding site [chemical binding]; other site 762570001444 Mg2+ binding site [ion binding]; other site 762570001445 G-X-G motif; other site 762570001446 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762570001447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570001448 active site 762570001449 phosphorylation site [posttranslational modification] 762570001450 intermolecular recognition site; other site 762570001451 dimerization interface [polypeptide binding]; other site 762570001452 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762570001453 DNA binding site [nucleotide binding] 762570001454 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762570001455 HlyD family secretion protein; Region: HlyD_3; pfam13437 762570001456 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 762570001457 Outer membrane efflux protein; Region: OEP; pfam02321 762570001458 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 762570001459 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 762570001460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762570001461 Q-loop/lid; other site 762570001462 ABC transporter signature motif; other site 762570001463 Walker B; other site 762570001464 D-loop; other site 762570001465 H-loop/switch region; other site 762570001466 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 762570001467 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762570001468 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762570001469 metal-binding site [ion binding] 762570001470 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762570001471 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762570001472 motif II; other site 762570001473 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 762570001474 Alkaline phosphatase homologues; Region: alkPPc; smart00098 762570001475 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 762570001476 active site 762570001477 dimer interface [polypeptide binding]; other site 762570001478 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 762570001479 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 762570001480 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 762570001481 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 762570001482 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762570001483 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 762570001484 catalytic site [active] 762570001485 transcription termination factor Rho; Provisional; Region: PRK12608 762570001486 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762570001487 RNA binding site [nucleotide binding]; other site 762570001488 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762570001489 Walker A motif; other site 762570001490 ATP binding site [chemical binding]; other site 762570001491 Walker B motif; other site 762570001492 hypothetical protein; Reviewed; Region: PRK00024 762570001493 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 762570001494 helix-hairpin-helix signature motif; other site 762570001495 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 762570001496 MPN+ (JAMM) motif; other site 762570001497 Zinc-binding site [ion binding]; other site 762570001498 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 762570001499 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 762570001500 dockerin binding interface; other site 762570001501 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570001502 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 762570001503 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 762570001504 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 762570001505 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 762570001506 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 762570001507 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 762570001508 FAD binding domain; Region: FAD_binding_4; pfam01565 762570001509 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 762570001510 probable regulatory domain; Region: near_KaiC_dom; TIGR03879 762570001511 KaiC domain protein, AF_0795 family; Region: thermo_KaiC_2; TIGR03878 762570001512 KaiC; Region: KaiC; pfam06745 762570001513 Walker A motif; other site 762570001514 ATP binding site [chemical binding]; other site 762570001515 Walker B motif; other site 762570001516 Predicted methyltransferases [General function prediction only]; Region: COG1568 762570001517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570001518 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 762570001519 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 762570001520 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 762570001521 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 762570001522 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 762570001523 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 762570001524 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 762570001525 active site 762570001526 catalytic triad [active] 762570001527 oxyanion hole [active] 762570001528 switch loop; other site 762570001529 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762570001530 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762570001531 Walker A/P-loop; other site 762570001532 ATP binding site [chemical binding]; other site 762570001533 Q-loop/lid; other site 762570001534 ABC transporter signature motif; other site 762570001535 Walker B; other site 762570001536 D-loop; other site 762570001537 H-loop/switch region; other site 762570001538 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762570001539 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 762570001540 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762570001541 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 762570001542 metal binding site [ion binding]; metal-binding site 762570001543 dimer interface [polypeptide binding]; other site 762570001544 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 762570001545 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 762570001546 PA/protease or protease-like domain interface [polypeptide binding]; other site 762570001547 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 762570001548 Peptidase family M28; Region: Peptidase_M28; pfam04389 762570001549 metal binding site [ion binding]; metal-binding site 762570001550 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 762570001551 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 762570001552 metal ion-dependent adhesion site (MIDAS); other site 762570001553 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570001554 active site 762570001555 NTP binding site [chemical binding]; other site 762570001556 metal binding triad [ion binding]; metal-binding site 762570001557 antibiotic binding site [chemical binding]; other site 762570001558 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 762570001559 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570001560 active site 762570001561 NTP binding site [chemical binding]; other site 762570001562 metal binding triad [ion binding]; metal-binding site 762570001563 antibiotic binding site [chemical binding]; other site 762570001564 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 762570001565 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762570001566 active site 762570001567 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 762570001568 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 762570001569 ATP-binding site [chemical binding]; other site 762570001570 Gluconate-6-phosphate binding site [chemical binding]; other site 762570001571 Shikimate kinase; Region: SKI; pfam01202 762570001572 GntP family permease; Region: GntP_permease; pfam02447 762570001573 fructuronate transporter; Provisional; Region: PRK10034; cl15264 762570001574 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 762570001575 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 762570001576 metal binding site [ion binding]; metal-binding site 762570001577 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 762570001578 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 762570001579 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 762570001580 putative acyl-acceptor binding pocket; other site 762570001581 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 762570001582 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 762570001583 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 762570001584 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 762570001585 active site 762570001586 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 762570001587 homodimer interface [polypeptide binding]; other site 762570001588 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762570001589 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570001590 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 762570001591 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762570001592 active site 762570001593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570001594 S-adenosylmethionine binding site [chemical binding]; other site 762570001595 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762570001596 catalytic core [active] 762570001597 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 762570001598 chorismate binding enzyme; Region: Chorismate_bind; cl10555 762570001599 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 762570001600 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 762570001601 dimer interface [polypeptide binding]; other site 762570001602 tetramer interface [polypeptide binding]; other site 762570001603 PYR/PP interface [polypeptide binding]; other site 762570001604 TPP binding site [chemical binding]; other site 762570001605 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 762570001606 TPP-binding site; other site 762570001607 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 762570001608 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762570001609 catalytic loop [active] 762570001610 iron binding site [ion binding]; other site 762570001611 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 762570001612 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 762570001613 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 762570001614 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 762570001615 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 762570001616 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 762570001617 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 762570001618 UbiA prenyltransferase family; Region: UbiA; pfam01040 762570001619 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 762570001620 active site 762570001621 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 762570001622 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 762570001623 acyl-activating enzyme (AAE) consensus motif; other site 762570001624 putative AMP binding site [chemical binding]; other site 762570001625 putative active site [active] 762570001626 putative CoA binding site [chemical binding]; other site 762570001627 Response regulator receiver domain; Region: Response_reg; pfam00072 762570001628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570001629 active site 762570001630 phosphorylation site [posttranslational modification] 762570001631 intermolecular recognition site; other site 762570001632 dimerization interface [polypeptide binding]; other site 762570001633 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 762570001634 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 762570001635 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 762570001636 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 762570001637 anti sigma factor interaction site; other site 762570001638 regulatory phosphorylation site [posttranslational modification]; other site 762570001639 B3/4 domain; Region: B3_4; pfam03483 762570001640 OstA-like protein; Region: OstA; cl00844 762570001641 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 762570001642 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 762570001643 Walker A/P-loop; other site 762570001644 ATP binding site [chemical binding]; other site 762570001645 Q-loop/lid; other site 762570001646 ABC transporter signature motif; other site 762570001647 Walker B; other site 762570001648 D-loop; other site 762570001649 H-loop/switch region; other site 762570001650 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 762570001651 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 762570001652 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 762570001653 Ligand Binding Site [chemical binding]; other site 762570001654 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762570001655 active site residue [active] 762570001656 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 762570001657 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 762570001658 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 762570001659 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 762570001660 glutaminase active site [active] 762570001661 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 762570001662 dimer interface [polypeptide binding]; other site 762570001663 active site 762570001664 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 762570001665 dimer interface [polypeptide binding]; other site 762570001666 active site 762570001667 peptide chain release factor 1; Validated; Region: prfA; PRK00591 762570001668 This domain is found in peptide chain release factors; Region: PCRF; smart00937 762570001669 RF-1 domain; Region: RF-1; pfam00472 762570001670 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 762570001671 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 762570001672 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 762570001673 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 762570001674 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 762570001675 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 762570001676 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 762570001677 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 762570001678 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 762570001679 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762570001680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762570001681 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 762570001682 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762570001683 ABC-ATPase subunit interface; other site 762570001684 dimer interface [polypeptide binding]; other site 762570001685 putative PBP binding regions; other site 762570001686 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 762570001687 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 762570001688 intersubunit interface [polypeptide binding]; other site 762570001689 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 762570001690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570001691 active site 762570001692 phosphorylation site [posttranslational modification] 762570001693 intermolecular recognition site; other site 762570001694 dimerization interface [polypeptide binding]; other site 762570001695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570001696 Walker A motif; other site 762570001697 ATP binding site [chemical binding]; other site 762570001698 Walker B motif; other site 762570001699 arginine finger; other site 762570001700 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762570001701 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 762570001702 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 762570001703 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 762570001704 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 762570001705 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 762570001706 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 762570001707 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762570001708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762570001709 DNA binding site [nucleotide binding] 762570001710 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 762570001711 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 762570001712 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762570001713 Zn2+ binding site [ion binding]; other site 762570001714 Mg2+ binding site [ion binding]; other site 762570001715 Cell division protein ZapA; Region: ZapA; pfam05164 762570001716 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 762570001717 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 762570001718 putative tRNA-binding site [nucleotide binding]; other site 762570001719 B3/4 domain; Region: B3_4; pfam03483 762570001720 tRNA synthetase B5 domain; Region: B5; smart00874 762570001721 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 762570001722 dimer interface [polypeptide binding]; other site 762570001723 motif 1; other site 762570001724 motif 3; other site 762570001725 motif 2; other site 762570001726 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 762570001727 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 762570001728 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 762570001729 dimer interface [polypeptide binding]; other site 762570001730 motif 1; other site 762570001731 active site 762570001732 motif 2; other site 762570001733 motif 3; other site 762570001734 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 762570001735 23S rRNA binding site [nucleotide binding]; other site 762570001736 L21 binding site [polypeptide binding]; other site 762570001737 L13 binding site [polypeptide binding]; other site 762570001738 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 762570001739 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 762570001740 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 762570001741 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 762570001742 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 762570001743 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 762570001744 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 762570001745 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 762570001746 active site 762570001747 dimer interface [polypeptide binding]; other site 762570001748 motif 1; other site 762570001749 motif 2; other site 762570001750 motif 3; other site 762570001751 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 762570001752 anticodon binding site; other site 762570001753 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 762570001754 Active_site [active] 762570001755 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 762570001756 DNA polymerase III subunit delta'; Validated; Region: PRK05564 762570001757 DNA polymerase III subunit delta'; Validated; Region: PRK08485 762570001758 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 762570001759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 762570001760 TPR motif; other site 762570001761 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 762570001762 isocitrate lyase; Provisional; Region: PRK15063 762570001763 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762570001764 tetramer interface [polypeptide binding]; other site 762570001765 active site 762570001766 Mg2+/Mn2+ binding site [ion binding]; other site 762570001767 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762570001768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762570001769 non-specific DNA binding site [nucleotide binding]; other site 762570001770 salt bridge; other site 762570001771 sequence-specific DNA binding site [nucleotide binding]; other site 762570001772 Domain of unknown function (DUF955); Region: DUF955; pfam06114 762570001773 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 762570001774 active site 762570001775 substrate binding site [chemical binding]; other site 762570001776 ATP binding site [chemical binding]; other site 762570001777 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 762570001778 oligomerisation interface [polypeptide binding]; other site 762570001779 mobile loop; other site 762570001780 roof hairpin; other site 762570001781 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 762570001782 Na binding site [ion binding]; other site 762570001783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570001784 Response regulator receiver domain; Region: Response_reg; pfam00072 762570001785 active site 762570001786 phosphorylation site [posttranslational modification] 762570001787 intermolecular recognition site; other site 762570001788 dimerization interface [polypeptide binding]; other site 762570001789 Probable transposase; Region: OrfB_IS605; pfam01385 762570001790 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 762570001791 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 762570001792 HDOD domain; Region: HDOD; pfam08668 762570001793 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 762570001794 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 762570001795 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 762570001796 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 762570001797 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 762570001798 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 762570001799 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 762570001800 Rod binding protein; Region: Rod-binding; cl01626 762570001801 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 762570001802 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 762570001803 Flagellar L-ring protein; Region: FlgH; cl17277 762570001804 SAF-like; Region: SAF_2; pfam13144 762570001805 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 762570001806 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 762570001807 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 762570001808 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 762570001809 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 762570001810 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 762570001811 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 762570001812 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 762570001813 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 762570001814 GAF domain; Region: GAF; pfam01590 762570001815 PAS domain S-box; Region: sensory_box; TIGR00229 762570001816 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570001817 putative active site [active] 762570001818 heme pocket [chemical binding]; other site 762570001819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 762570001820 Histidine kinase; Region: HisKA_3; pfam07730 762570001821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570001822 ATP binding site [chemical binding]; other site 762570001823 Mg2+ binding site [ion binding]; other site 762570001824 G-X-G motif; other site 762570001825 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762570001826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570001827 active site 762570001828 phosphorylation site [posttranslational modification] 762570001829 intermolecular recognition site; other site 762570001830 dimerization interface [polypeptide binding]; other site 762570001831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762570001832 DNA binding residues [nucleotide binding] 762570001833 dimerization interface [polypeptide binding]; other site 762570001834 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570001835 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570001836 Putative zinc-finger; Region: zf-HC2; pfam13490 762570001837 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 762570001838 dimer interface [polypeptide binding]; other site 762570001839 Citrate synthase; Region: Citrate_synt; pfam00285 762570001840 active site 762570001841 citrylCoA binding site [chemical binding]; other site 762570001842 NADH binding [chemical binding]; other site 762570001843 cationic pore residues; other site 762570001844 oxalacetate/citrate binding site [chemical binding]; other site 762570001845 coenzyme A binding site [chemical binding]; other site 762570001846 catalytic triad [active] 762570001847 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 762570001848 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 762570001849 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 762570001850 putative catalytic residues [active] 762570001851 nucleotide binding site [chemical binding]; other site 762570001852 aspartate binding site [chemical binding]; other site 762570001853 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 762570001854 dimer interface [polypeptide binding]; other site 762570001855 putative threonine allosteric regulatory site; other site 762570001856 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 762570001857 putative threonine allosteric regulatory site; other site 762570001858 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 762570001859 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 762570001860 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762570001861 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762570001862 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 762570001863 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 762570001864 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 762570001865 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 762570001866 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 762570001867 active site 762570001868 multimer interface [polypeptide binding]; other site 762570001869 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762570001870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762570001871 DNA-binding site [nucleotide binding]; DNA binding site 762570001872 UTRA domain; Region: UTRA; pfam07702 762570001873 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 762570001874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762570001875 FeS/SAM binding site; other site 762570001876 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 762570001877 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570001878 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 762570001879 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762570001880 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 762570001881 Phosphotransferase enzyme family; Region: APH; pfam01636 762570001882 putative active site [active] 762570001883 putative substrate binding site [chemical binding]; other site 762570001884 ATP binding site [chemical binding]; other site 762570001885 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762570001886 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762570001887 active site 762570001888 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762570001889 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762570001890 active site 762570001891 short chain dehydrogenase; Provisional; Region: PRK07035 762570001892 classical (c) SDRs; Region: SDR_c; cd05233 762570001893 NAD(P) binding site [chemical binding]; other site 762570001894 active site 762570001895 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762570001896 Amidase; Region: Amidase; pfam01425 762570001897 enoyl-CoA hydratase; Provisional; Region: PRK06688 762570001898 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762570001899 substrate binding site [chemical binding]; other site 762570001900 oxyanion hole (OAH) forming residues; other site 762570001901 trimer interface [polypeptide binding]; other site 762570001902 short chain dehydrogenase; Provisional; Region: PRK08278 762570001903 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 762570001904 NAD(P) binding site [chemical binding]; other site 762570001905 homodimer interface [polypeptide binding]; other site 762570001906 active site 762570001907 4-coumarate--CoA ligase; Region: PLN02246 762570001908 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 762570001909 acyl-activating enzyme (AAE) consensus motif; other site 762570001910 active site 762570001911 putative CoA binding site [chemical binding]; other site 762570001912 AMP binding site [chemical binding]; other site 762570001913 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570001914 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570001915 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 762570001916 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570001917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762570001918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762570001919 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 762570001920 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762570001921 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762570001922 SCP-2 sterol transfer family; Region: SCP2; pfam02036 762570001923 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 762570001924 lipoyl synthase; Provisional; Region: PRK05481 762570001925 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762570001926 FeS/SAM binding site; other site 762570001927 L-lysine aminotransferase; Provisional; Region: PRK08297 762570001928 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762570001929 inhibitor-cofactor binding pocket; inhibition site 762570001930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570001931 catalytic residue [active] 762570001932 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 762570001933 DNA gyrase subunit A; Validated; Region: PRK05560 762570001934 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 762570001935 CAP-like domain; other site 762570001936 active site 762570001937 primary dimer interface [polypeptide binding]; other site 762570001938 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762570001939 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762570001940 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762570001941 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762570001942 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762570001943 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762570001944 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 762570001945 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 762570001946 active site 762570001947 catalytic site [active] 762570001948 isocitrate dehydrogenase; Validated; Region: PRK09222 762570001949 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 762570001950 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 762570001951 nudix motif; other site 762570001952 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762570001953 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762570001954 N-terminal plug; other site 762570001955 ligand-binding site [chemical binding]; other site 762570001956 Stage II sporulation protein; Region: SpoIID; pfam08486 762570001957 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 762570001958 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 762570001959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570001960 active site 762570001961 phosphorylation site [posttranslational modification] 762570001962 intermolecular recognition site; other site 762570001963 dimerization interface [polypeptide binding]; other site 762570001964 LytTr DNA-binding domain; Region: LytTR; smart00850 762570001965 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 762570001966 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 762570001967 GAF domain; Region: GAF; cl17456 762570001968 Histidine kinase; Region: His_kinase; pfam06580 762570001969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570001970 ATP binding site [chemical binding]; other site 762570001971 Mg2+ binding site [ion binding]; other site 762570001972 G-X-G motif; other site 762570001973 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 762570001974 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 762570001975 active site 762570001976 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 762570001977 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 762570001978 nucleotide binding site [chemical binding]; other site 762570001979 NEF interaction site [polypeptide binding]; other site 762570001980 SBD interface [polypeptide binding]; other site 762570001981 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 762570001982 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762570001983 active site 762570001984 competence damage-inducible protein A; Provisional; Region: PRK00549 762570001985 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 762570001986 putative MPT binding site; other site 762570001987 Competence-damaged protein; Region: CinA; pfam02464 762570001988 recombinase A; Provisional; Region: recA; PRK09354 762570001989 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 762570001990 hexamer interface [polypeptide binding]; other site 762570001991 Walker A motif; other site 762570001992 ATP binding site [chemical binding]; other site 762570001993 Walker B motif; other site 762570001994 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 762570001995 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 762570001996 active site 762570001997 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762570001998 dimerization interface [polypeptide binding]; other site 762570001999 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762570002000 dimerization interface [polypeptide binding]; other site 762570002001 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762570002002 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762570002003 dimer interface [polypeptide binding]; other site 762570002004 putative CheW interface [polypeptide binding]; other site 762570002005 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 762570002006 Uncharacterized conserved protein [Function unknown]; Region: COG4198 762570002007 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 762570002008 putative ligand binding site [chemical binding]; other site 762570002009 putative NAD binding site [chemical binding]; other site 762570002010 putative catalytic site [active] 762570002011 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 762570002012 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762570002013 catalytic residue [active] 762570002014 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 762570002015 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 762570002016 ligand binding site [chemical binding]; other site 762570002017 homodimer interface [polypeptide binding]; other site 762570002018 NAD(P) binding site [chemical binding]; other site 762570002019 trimer interface B [polypeptide binding]; other site 762570002020 trimer interface A [polypeptide binding]; other site 762570002021 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 762570002022 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 762570002023 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 762570002024 spermidine synthase; Provisional; Region: PRK00811 762570002025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570002026 S-adenosylmethionine binding site [chemical binding]; other site 762570002027 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 762570002028 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762570002029 catalytic residue [active] 762570002030 DivIVA protein; Region: DivIVA; pfam05103 762570002031 DivIVA domain; Region: DivI1A_domain; TIGR03544 762570002032 purine nucleoside phosphorylase; Provisional; Region: PRK08202 762570002033 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762570002034 Bacterial transcriptional regulator; Region: IclR; pfam01614 762570002035 malate synthase A; Region: malate_syn_A; TIGR01344 762570002036 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 762570002037 active site 762570002038 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762570002039 catalytic loop [active] 762570002040 iron binding site [ion binding]; other site 762570002041 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 762570002042 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762570002043 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762570002044 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762570002045 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 762570002046 SLBB domain; Region: SLBB; pfam10531 762570002047 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 762570002048 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 762570002049 putative active site [active] 762570002050 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 762570002051 putative active site [active] 762570002052 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 762570002053 putative active site [active] 762570002054 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 762570002055 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 762570002056 putative dimer interface [polypeptide binding]; other site 762570002057 [2Fe-2S] cluster binding site [ion binding]; other site 762570002058 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 762570002059 NADH dehydrogenase subunit D; Validated; Region: PRK06075 762570002060 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 762570002061 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 762570002062 NADH dehydrogenase subunit B; Validated; Region: PRK06411 762570002063 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 762570002064 adenylosuccinate lyase; Provisional; Region: PRK07492 762570002065 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 762570002066 tetramer interface [polypeptide binding]; other site 762570002067 active site 762570002068 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 762570002069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570002070 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570002071 DNA binding residues [nucleotide binding] 762570002072 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 762570002073 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 762570002074 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 762570002075 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 762570002076 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762570002077 dimerization interface [polypeptide binding]; other site 762570002078 putative DNA binding site [nucleotide binding]; other site 762570002079 putative Zn2+ binding site [ion binding]; other site 762570002080 AsnC family; Region: AsnC_trans_reg; pfam01037 762570002081 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570002082 active site 762570002083 NTP binding site [chemical binding]; other site 762570002084 metal binding triad [ion binding]; metal-binding site 762570002085 antibiotic binding site [chemical binding]; other site 762570002086 HEPN domain; Region: HEPN; pfam05168 762570002087 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 762570002088 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762570002089 catalytic triad [active] 762570002090 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 762570002091 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 762570002092 ssDNA binding site; other site 762570002093 generic binding surface II; other site 762570002094 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762570002095 ATP binding site [chemical binding]; other site 762570002096 putative Mg++ binding site [ion binding]; other site 762570002097 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762570002098 nucleotide binding region [chemical binding]; other site 762570002099 ATP-binding site [chemical binding]; other site 762570002100 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 762570002101 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 762570002102 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 762570002103 active site 762570002104 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 762570002105 catalytic triad [active] 762570002106 dimer interface [polypeptide binding]; other site 762570002107 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762570002108 classical (c) SDRs; Region: SDR_c; cd05233 762570002109 NAD(P) binding site [chemical binding]; other site 762570002110 active site 762570002111 Homeodomain-like domain; Region: HTH_23; pfam13384 762570002112 Winged helix-turn helix; Region: HTH_29; pfam13551 762570002113 Homeodomain-like domain; Region: HTH_32; pfam13565 762570002114 DDE superfamily endonuclease; Region: DDE_3; pfam13358 762570002115 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570002116 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762570002117 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 762570002118 N-terminal plug; other site 762570002119 ligand-binding site [chemical binding]; other site 762570002120 hypothetical protein; Provisional; Region: PRK08201 762570002121 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 762570002122 metal binding site [ion binding]; metal-binding site 762570002123 putative dimer interface [polypeptide binding]; other site 762570002124 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 762570002125 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 762570002126 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762570002127 Beta-Casp domain; Region: Beta-Casp; pfam10996 762570002128 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 762570002129 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762570002130 FAD binding domain; Region: FAD_binding_4; pfam01565 762570002131 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 762570002132 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 762570002133 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 762570002134 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 762570002135 NAD(P) binding site [chemical binding]; other site 762570002136 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 762570002137 tandem repeat interface [polypeptide binding]; other site 762570002138 oligomer interface [polypeptide binding]; other site 762570002139 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 762570002140 active site residues [active] 762570002141 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 762570002142 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 762570002143 tandem repeat interface [polypeptide binding]; other site 762570002144 oligomer interface [polypeptide binding]; other site 762570002145 active site residues [active] 762570002146 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 762570002147 GrpE; Region: GrpE; pfam01025 762570002148 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 762570002149 dimer interface [polypeptide binding]; other site 762570002150 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 762570002151 chaperone protein DnaJ; Provisional; Region: PRK14281 762570002152 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 762570002153 HSP70 interaction site [polypeptide binding]; other site 762570002154 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 762570002155 substrate binding site [polypeptide binding]; other site 762570002156 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 762570002157 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 762570002158 dimer interface [polypeptide binding]; other site 762570002159 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 762570002160 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 762570002161 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 762570002162 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 762570002163 tetramer interface [polypeptide binding]; other site 762570002164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570002165 catalytic residue [active] 762570002166 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 762570002167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 762570002168 Bacterial PH domain; Region: DUF304; cl01348 762570002169 Bacterial PH domain; Region: DUF304; pfam03703 762570002170 Bacterial PH domain; Region: DUF304; pfam03703 762570002171 Bacterial PH domain; Region: DUF304; pfam03703 762570002172 aminodeoxychorismate synthase; Provisional; Region: PRK07508 762570002173 chorismate binding enzyme; Region: Chorismate_bind; cl10555 762570002174 hypothetical protein; Provisional; Region: PRK07546 762570002175 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 762570002176 homodimer interface [polypeptide binding]; other site 762570002177 substrate-cofactor binding pocket; other site 762570002178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570002179 catalytic residue [active] 762570002180 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 762570002181 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762570002182 ligand binding site [chemical binding]; other site 762570002183 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 762570002184 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 762570002185 metal binding triad; other site 762570002186 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 762570002187 Na2 binding site [ion binding]; other site 762570002188 putative substrate binding site 1 [chemical binding]; other site 762570002189 Na binding site 1 [ion binding]; other site 762570002190 putative substrate binding site 2 [chemical binding]; other site 762570002191 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 762570002192 Domain of unknown function DUF21; Region: DUF21; pfam01595 762570002193 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762570002194 Transporter associated domain; Region: CorC_HlyC; smart01091 762570002195 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 762570002196 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 762570002197 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 762570002198 active site 762570002199 tetramer interface [polypeptide binding]; other site 762570002200 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762570002201 active site 762570002202 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 762570002203 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762570002204 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 762570002205 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762570002206 active site 762570002207 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 762570002208 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 762570002209 active site 762570002210 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 762570002211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762570002212 active site 762570002213 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 762570002214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570002215 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762570002216 Walker A motif; other site 762570002217 ATP binding site [chemical binding]; other site 762570002218 Walker B motif; other site 762570002219 arginine finger; other site 762570002220 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 762570002221 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 762570002222 putative active site; other site 762570002223 catalytic residue [active] 762570002224 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762570002225 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762570002226 hydroxyglutarate oxidase; Provisional; Region: PRK11728 762570002227 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 762570002228 hydroxyglutarate oxidase; Provisional; Region: PRK11728 762570002229 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 762570002230 thiS-thiF/thiG interaction site; other site 762570002231 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 762570002232 ThiS interaction site; other site 762570002233 putative active site [active] 762570002234 tetramer interface [polypeptide binding]; other site 762570002235 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 762570002236 active site 762570002237 thiamine phosphate binding site [chemical binding]; other site 762570002238 pyrophosphate binding site [ion binding]; other site 762570002239 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 762570002240 dimer interface [polypeptide binding]; other site 762570002241 substrate binding site [chemical binding]; other site 762570002242 ATP binding site [chemical binding]; other site 762570002243 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 762570002244 DEAD/DEAH box helicase; Region: DEAD; pfam00270 762570002245 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 762570002246 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 762570002247 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762570002248 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762570002249 active site 762570002250 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762570002251 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 762570002252 PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121 762570002253 apical/protease domain interface [polypeptide binding]; other site 762570002254 substrate binding [chemical binding]; other site 762570002255 dimer interface [polypeptide binding]; other site 762570002256 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 762570002257 Peptidase family M28; Region: Peptidase_M28; pfam04389 762570002258 metal binding site [ion binding]; metal-binding site 762570002259 Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253 762570002260 allantoate amidohydrolase; Reviewed; Region: PRK09290 762570002261 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 762570002262 active site 762570002263 metal binding site [ion binding]; metal-binding site 762570002264 dimer interface [polypeptide binding]; other site 762570002265 aconitate hydratase; Validated; Region: PRK09277 762570002266 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 762570002267 substrate binding site [chemical binding]; other site 762570002268 ligand binding site [chemical binding]; other site 762570002269 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 762570002270 substrate binding site [chemical binding]; other site 762570002271 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762570002272 FecR protein; Region: FecR; pfam04773 762570002273 starch binding outer membrane protein SusD; Region: SusD; cd08977 762570002274 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 762570002275 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 762570002276 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 762570002277 transmembrane helices; other site 762570002278 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 762570002279 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 762570002280 active site 762570002281 trimer interface [polypeptide binding]; other site 762570002282 allosteric site; other site 762570002283 active site lid [active] 762570002284 hexamer (dimer of trimers) interface [polypeptide binding]; other site 762570002285 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 762570002286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762570002287 putative substrate translocation pore; other site 762570002288 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 762570002289 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570002290 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570002291 DNA binding residues [nucleotide binding] 762570002292 UPF0489 domain; Region: UPF0489; pfam12640 762570002293 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 762570002294 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 762570002295 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 762570002296 Asparagine synthase; Region: Asn_synthase; pfam00733 762570002297 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762570002298 FAD binding domain; Region: FAD_binding_4; pfam01565 762570002299 Berberine and berberine like; Region: BBE; pfam08031 762570002300 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 762570002301 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 762570002302 catalytic motif [active] 762570002303 Zn binding site [ion binding]; other site 762570002304 RibD C-terminal domain; Region: RibD_C; cl17279 762570002305 HDOD domain; Region: HDOD; pfam08668 762570002306 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762570002307 Zn2+ binding site [ion binding]; other site 762570002308 Mg2+ binding site [ion binding]; other site 762570002309 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 762570002310 Lumazine binding domain; Region: Lum_binding; pfam00677 762570002311 Lumazine binding domain; Region: Lum_binding; pfam00677 762570002312 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 762570002313 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 762570002314 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762570002315 FeS/SAM binding site; other site 762570002316 TRAM domain; Region: TRAM; pfam01938 762570002317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570002318 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762570002319 Walker A motif; other site 762570002320 ATP binding site [chemical binding]; other site 762570002321 Walker B motif; other site 762570002322 arginine finger; other site 762570002323 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762570002324 Lipopolysaccharide-assembly; Region: LptE; pfam04390 762570002325 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 762570002326 thiamine monophosphate kinase; Provisional; Region: PRK05731 762570002327 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 762570002328 ATP binding site [chemical binding]; other site 762570002329 dimerization interface [polypeptide binding]; other site 762570002330 CsbD-like; Region: CsbD; pfam05532 762570002331 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 762570002332 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 762570002333 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 762570002334 dimerization interface [polypeptide binding]; other site 762570002335 active site 762570002336 Preprotein translocase subunit; Region: YajC; pfam02699 762570002337 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762570002338 primosomal protein N' Region: priA; TIGR00595 762570002339 ATP binding site [chemical binding]; other site 762570002340 putative Mg++ binding site [ion binding]; other site 762570002341 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762570002342 ATP-binding site [chemical binding]; other site 762570002343 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 762570002344 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 762570002345 substrate binding site [chemical binding]; other site 762570002346 hexamer interface [polypeptide binding]; other site 762570002347 metal binding site [ion binding]; metal-binding site 762570002348 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 762570002349 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 762570002350 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 762570002351 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 762570002352 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762570002353 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 762570002354 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 762570002355 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 762570002356 HIGH motif; other site 762570002357 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 762570002358 active site 762570002359 KMSKS motif; other site 762570002360 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 762570002361 tRNA binding surface [nucleotide binding]; other site 762570002362 anticodon binding site; other site 762570002363 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 762570002364 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 762570002365 GTP-binding protein LepA; Provisional; Region: PRK05433 762570002366 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 762570002367 G1 box; other site 762570002368 putative GEF interaction site [polypeptide binding]; other site 762570002369 GTP/Mg2+ binding site [chemical binding]; other site 762570002370 Switch I region; other site 762570002371 G2 box; other site 762570002372 G3 box; other site 762570002373 Switch II region; other site 762570002374 G4 box; other site 762570002375 G5 box; other site 762570002376 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 762570002377 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 762570002378 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 762570002379 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 762570002380 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762570002381 Catalytic site [active] 762570002382 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762570002383 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 762570002384 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762570002385 Catalytic site [active] 762570002386 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762570002387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 762570002388 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 762570002389 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 762570002390 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762570002391 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 762570002392 putative NAD(P) binding site [chemical binding]; other site 762570002393 putative active site [active] 762570002394 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 762570002395 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762570002396 active site 2 [active] 762570002397 active site 1 [active] 762570002398 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 762570002399 active site 762570002400 oxidoreductase; Validated; Region: PRK05717 762570002401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762570002402 NAD(P) binding site [chemical binding]; other site 762570002403 active site 762570002404 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 762570002405 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 762570002406 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762570002407 Walker A motif; other site 762570002408 ATP binding site [chemical binding]; other site 762570002409 Walker B motif; other site 762570002410 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 762570002411 Zn binding site [ion binding]; other site 762570002412 Double zinc ribbon; Region: DZR; pfam12773 762570002413 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 762570002414 TPR repeat; Region: TPR_11; pfam13414 762570002415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570002416 TPR motif; other site 762570002417 binding surface 762570002418 Repair protein; Region: Repair_PSII; cl01535 762570002419 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762570002420 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762570002421 active site 762570002422 metal binding site [ion binding]; metal-binding site 762570002423 Tetratricopeptide repeat; Region: TPR_12; pfam13424 762570002424 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 762570002425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570002426 Walker A motif; other site 762570002427 ATP binding site [chemical binding]; other site 762570002428 Walker B motif; other site 762570002429 arginine finger; other site 762570002430 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762570002431 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 762570002432 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 762570002433 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 762570002434 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 762570002435 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762570002436 catalytic residue [active] 762570002437 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 762570002438 FeS assembly protein SufD; Region: sufD; TIGR01981 762570002439 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 762570002440 FeS assembly ATPase SufC; Region: sufC; TIGR01978 762570002441 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 762570002442 Walker A/P-loop; other site 762570002443 ATP binding site [chemical binding]; other site 762570002444 Q-loop/lid; other site 762570002445 ABC transporter signature motif; other site 762570002446 Walker B; other site 762570002447 D-loop; other site 762570002448 H-loop/switch region; other site 762570002449 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 762570002450 putative ABC transporter; Region: ycf24; CHL00085 762570002451 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 762570002452 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 762570002453 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 762570002454 FOG: CBS domain [General function prediction only]; Region: COG0517 762570002455 NosL; Region: NosL; cl01769 762570002456 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 762570002457 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762570002458 Walker A/P-loop; other site 762570002459 ATP binding site [chemical binding]; other site 762570002460 Q-loop/lid; other site 762570002461 ABC transporter signature motif; other site 762570002462 Walker B; other site 762570002463 D-loop; other site 762570002464 H-loop/switch region; other site 762570002465 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 762570002466 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 762570002467 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 762570002468 Cytochrome c; Region: Cytochrom_C; pfam00034 762570002469 Rrf2 family protein; Region: rrf2_super; TIGR00738 762570002470 Transcriptional regulator; Region: Rrf2; pfam02082 762570002471 Rrf2 family protein; Region: rrf2_super; TIGR00738 762570002472 Transcriptional regulator; Region: Rrf2; pfam02082 762570002473 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762570002474 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 762570002475 NAD(P) binding site [chemical binding]; other site 762570002476 catalytic residues [active] 762570002477 Uncharacterized conserved protein [Function unknown]; Region: COG4095 762570002478 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 762570002479 catalytic center binding site [active] 762570002480 ATP binding site [chemical binding]; other site 762570002481 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 762570002482 Substrate-binding site [chemical binding]; other site 762570002483 Substrate specificity [chemical binding]; other site 762570002484 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 762570002485 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 762570002486 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 762570002487 catalytic site [active] 762570002488 subunit interface [polypeptide binding]; other site 762570002489 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762570002490 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 762570002491 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762570002492 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 762570002493 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 762570002494 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762570002495 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 762570002496 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762570002497 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 762570002498 putative FMN binding site [chemical binding]; other site 762570002499 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570002500 active site 762570002501 NTP binding site [chemical binding]; other site 762570002502 metal binding triad [ion binding]; metal-binding site 762570002503 antibiotic binding site [chemical binding]; other site 762570002504 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570002505 active site 762570002506 NTP binding site [chemical binding]; other site 762570002507 metal binding triad [ion binding]; metal-binding site 762570002508 antibiotic binding site [chemical binding]; other site 762570002509 HEPN domain; Region: HEPN; cl00824 762570002510 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 762570002511 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 762570002512 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 762570002513 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 762570002514 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 762570002515 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 762570002516 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 762570002517 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 762570002518 Uncharacterized conserved protein [Function unknown]; Region: COG1739 762570002519 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 762570002520 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 762570002521 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 762570002522 Uncharacterized conserved protein [Function unknown]; Region: COG1656 762570002523 Protein of unknown function DUF82; Region: DUF82; pfam01927 762570002524 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 762570002525 RNA/DNA hybrid binding site [nucleotide binding]; other site 762570002526 active site 762570002527 GTPase CgtA; Reviewed; Region: obgE; PRK12299 762570002528 GTP1/OBG; Region: GTP1_OBG; pfam01018 762570002529 Obg GTPase; Region: Obg; cd01898 762570002530 G1 box; other site 762570002531 GTP/Mg2+ binding site [chemical binding]; other site 762570002532 Switch I region; other site 762570002533 G2 box; other site 762570002534 G3 box; other site 762570002535 Switch II region; other site 762570002536 G4 box; other site 762570002537 G5 box; other site 762570002538 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 762570002539 DNA protecting protein DprA; Region: dprA; TIGR00732 762570002540 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 762570002541 putative catalytic site [active] 762570002542 putative metal binding site [ion binding]; other site 762570002543 putative phosphate binding site [ion binding]; other site 762570002544 glycogen synthase; Provisional; Region: glgA; PRK00654 762570002545 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 762570002546 ADP-binding pocket [chemical binding]; other site 762570002547 homodimer interface [polypeptide binding]; other site 762570002548 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 762570002549 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 762570002550 ligand binding site; other site 762570002551 oligomer interface; other site 762570002552 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 762570002553 dimer interface [polypeptide binding]; other site 762570002554 N-terminal domain interface [polypeptide binding]; other site 762570002555 sulfate 1 binding site; other site 762570002556 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762570002557 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570002558 HDOD domain; Region: HDOD; pfam08668 762570002559 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 762570002560 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 762570002561 active site 762570002562 dimer interface [polypeptide binding]; other site 762570002563 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762570002564 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762570002565 active site 762570002566 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 762570002567 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 762570002568 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 762570002569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762570002570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762570002571 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762570002572 Peptidase family M23; Region: Peptidase_M23; pfam01551 762570002573 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 762570002574 TPR repeat; Region: TPR_11; pfam13414 762570002575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570002576 binding surface 762570002577 TPR motif; other site 762570002578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570002579 TPR motif; other site 762570002580 binding surface 762570002581 Tetratricopeptide repeat; Region: TPR_16; pfam13432 762570002582 seryl-tRNA synthetase; Provisional; Region: PRK05431 762570002583 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 762570002584 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 762570002585 dimer interface [polypeptide binding]; other site 762570002586 active site 762570002587 motif 1; other site 762570002588 motif 2; other site 762570002589 motif 3; other site 762570002590 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 762570002591 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 762570002592 NADP binding site [chemical binding]; other site 762570002593 active site 762570002594 putative substrate binding site [chemical binding]; other site 762570002595 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 762570002596 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 762570002597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 762570002598 binding surface 762570002599 TPR motif; other site 762570002600 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 762570002601 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 762570002602 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 762570002603 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 762570002604 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 762570002605 RIP metalloprotease RseP; Region: TIGR00054 762570002606 active site 762570002607 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 762570002608 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 762570002609 protein binding site [polypeptide binding]; other site 762570002610 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 762570002611 putative substrate binding region [chemical binding]; other site 762570002612 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 762570002613 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 762570002614 catalytic residue [active] 762570002615 putative FPP diphosphate binding site; other site 762570002616 putative FPP binding hydrophobic cleft; other site 762570002617 dimer interface [polypeptide binding]; other site 762570002618 putative IPP diphosphate binding site; other site 762570002619 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 762570002620 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 762570002621 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 762570002622 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 762570002623 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 762570002624 Surface antigen; Region: Bac_surface_Ag; pfam01103 762570002625 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 762570002626 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 762570002627 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 762570002628 oligomerization interface [polypeptide binding]; other site 762570002629 active site 762570002630 metal binding site [ion binding]; metal-binding site 762570002631 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 762570002632 Uncharacterized conserved protein [Function unknown]; Region: COG0432 762570002633 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 762570002634 putative active site [active] 762570002635 metal binding site [ion binding]; metal-binding site 762570002636 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 762570002637 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 762570002638 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 762570002639 substrate binding site [chemical binding]; other site 762570002640 tetramer interface [polypeptide binding]; other site 762570002641 catalytic residue [active] 762570002642 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 762570002643 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 762570002644 active site 762570002645 Zn binding site [ion binding]; other site 762570002646 ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Region: COG2401 762570002647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762570002648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 762570002649 Walker A/P-loop; other site 762570002650 ATP binding site [chemical binding]; other site 762570002651 Q-loop/lid; other site 762570002652 ABC transporter signature motif; other site 762570002653 Walker B; other site 762570002654 D-loop; other site 762570002655 H-loop/switch region; other site 762570002656 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 762570002657 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 762570002658 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 762570002659 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 762570002660 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762570002661 Walker A/P-loop; other site 762570002662 ATP binding site [chemical binding]; other site 762570002663 Q-loop/lid; other site 762570002664 ABC transporter signature motif; other site 762570002665 Walker B; other site 762570002666 D-loop; other site 762570002667 H-loop/switch region; other site 762570002668 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 762570002669 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 762570002670 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 762570002671 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 762570002672 Protein of unknown function DUF72; Region: DUF72; cl00777 762570002673 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 762570002674 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 762570002675 nucleotide binding site/active site [active] 762570002676 HIT family signature motif; other site 762570002677 catalytic residue [active] 762570002678 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 762570002679 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 762570002680 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 762570002681 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 762570002682 homopentamer interface [polypeptide binding]; other site 762570002683 active site 762570002684 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 762570002685 Two component regulator propeller; Region: Reg_prop; pfam07494 762570002686 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570002687 Preprotein translocase SecG subunit; Region: SecG; pfam03840 762570002688 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 762570002689 dimer interface [polypeptide binding]; other site 762570002690 ADP-ribose binding site [chemical binding]; other site 762570002691 active site 762570002692 nudix motif; other site 762570002693 metal binding site [ion binding]; metal-binding site 762570002694 hypothetical protein; Provisional; Region: PRK02877 762570002695 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 762570002696 RNA methyltransferase, RsmE family; Region: TIGR00046 762570002697 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 762570002698 Surface antigen; Region: Bac_surface_Ag; pfam01103 762570002699 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 762570002700 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762570002701 minor groove reading motif; other site 762570002702 helix-hairpin-helix signature motif; other site 762570002703 substrate binding pocket [chemical binding]; other site 762570002704 active site 762570002705 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 762570002706 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 762570002707 active site 762570002708 8-oxo-dGMP binding site [chemical binding]; other site 762570002709 nudix motif; other site 762570002710 metal binding site [ion binding]; metal-binding site 762570002711 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 762570002712 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 762570002713 oligomerisation interface [polypeptide binding]; other site 762570002714 mobile loop; other site 762570002715 roof hairpin; other site 762570002716 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 762570002717 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 762570002718 ring oligomerisation interface [polypeptide binding]; other site 762570002719 ATP/Mg binding site [chemical binding]; other site 762570002720 stacking interactions; other site 762570002721 hinge regions; other site 762570002722 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 762570002723 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 762570002724 active site 762570002725 PHP Thumb interface [polypeptide binding]; other site 762570002726 metal binding site [ion binding]; metal-binding site 762570002727 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 762570002728 generic binding surface II; other site 762570002729 generic binding surface I; other site 762570002730 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 762570002731 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 762570002732 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 762570002733 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 762570002734 Na binding site [ion binding]; other site 762570002735 putative glycosylation site [posttranslational modification]; other site 762570002736 putative glycosylation site [posttranslational modification]; other site 762570002737 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 762570002738 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 762570002739 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 762570002740 substrate binding pocket [chemical binding]; other site 762570002741 chain length determination region; other site 762570002742 substrate-Mg2+ binding site; other site 762570002743 catalytic residues [active] 762570002744 aspartate-rich region 1; other site 762570002745 active site lid residues [active] 762570002746 aspartate-rich region 2; other site 762570002747 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 762570002748 putative substrate binding site 1 [chemical binding]; other site 762570002749 Na binding site 1 [ion binding]; other site 762570002750 Na2 binding site [ion binding]; other site 762570002751 putative substrate binding site 2 [chemical binding]; other site 762570002752 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 762570002753 active site 762570002754 Zn binding site [ion binding]; other site 762570002755 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 762570002756 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762570002757 catalytic residues [active] 762570002758 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 762570002759 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762570002760 putative catalytic residue [active] 762570002761 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 762570002762 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 762570002763 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762570002764 catalytic residues [active] 762570002765 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 762570002766 oligoendopeptidase F; Region: pepF; TIGR00181 762570002767 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 762570002768 active site 762570002769 Zn binding site [ion binding]; other site 762570002770 Bacterial Ig-like domain; Region: Big_5; pfam13205 762570002771 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570002772 Ribulose bisphosphate carboxylase like proteins (RLPs) similar to R.rubrum RLP; Region: RLP_RrRLP; cd08210 762570002773 dimer interface [polypeptide binding]; other site 762570002774 active site 762570002775 catalytic residue [active] 762570002776 metal binding site [ion binding]; metal-binding site 762570002777 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762570002778 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762570002779 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 762570002780 active site 762570002781 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 762570002782 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 762570002783 tRNA; other site 762570002784 putative tRNA binding site [nucleotide binding]; other site 762570002785 putative NADP binding site [chemical binding]; other site 762570002786 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 762570002787 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 762570002788 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 762570002789 domain interfaces; other site 762570002790 active site 762570002791 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 762570002792 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 762570002793 active site 762570002794 Uncharacterized conserved protein [Function unknown]; Region: COG0432 762570002795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 762570002796 Protein of unknown function (DUF433); Region: DUF433; pfam04255 762570002797 glycogen branching enzyme; Provisional; Region: PRK12313 762570002798 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 762570002799 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 762570002800 active site 762570002801 catalytic site [active] 762570002802 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 762570002803 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 762570002804 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 762570002805 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 762570002806 active site 762570002807 catalytic site [active] 762570002808 Cupin domain; Region: Cupin_2; pfam07883 762570002809 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 762570002810 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 762570002811 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 762570002812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570002813 Walker A motif; other site 762570002814 ATP binding site [chemical binding]; other site 762570002815 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 762570002816 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 762570002817 LabA_like proteins; Region: LabA_like; cd06167 762570002818 putative metal binding site [ion binding]; other site 762570002819 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 762570002820 active site 762570002821 HslU subunit interaction site [polypeptide binding]; other site 762570002822 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 762570002823 rod shape-determining protein MreC; Provisional; Region: PRK13922 762570002824 rod shape-determining protein MreC; Region: MreC; pfam04085 762570002825 rod shape-determining protein MreB; Provisional; Region: PRK13927 762570002826 MreB and similar proteins; Region: MreB_like; cd10225 762570002827 nucleotide binding site [chemical binding]; other site 762570002828 Mg binding site [ion binding]; other site 762570002829 putative protofilament interaction site [polypeptide binding]; other site 762570002830 RodZ interaction site [polypeptide binding]; other site 762570002831 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 762570002832 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 762570002833 purine monophosphate binding site [chemical binding]; other site 762570002834 dimer interface [polypeptide binding]; other site 762570002835 putative catalytic residues [active] 762570002836 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 762570002837 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 762570002838 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 762570002839 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 762570002840 active site 762570002841 substrate binding site [chemical binding]; other site 762570002842 cosubstrate binding site; other site 762570002843 catalytic site [active] 762570002844 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 762570002845 dimer interface [polypeptide binding]; other site 762570002846 catalytic triad [active] 762570002847 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 762570002848 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 762570002849 oligomer interface [polypeptide binding]; other site 762570002850 metal binding site [ion binding]; metal-binding site 762570002851 metal binding site [ion binding]; metal-binding site 762570002852 Cl binding site [ion binding]; other site 762570002853 aspartate ring; other site 762570002854 basic sphincter; other site 762570002855 putative hydrophobic gate; other site 762570002856 periplasmic entrance; other site 762570002857 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 762570002858 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 762570002859 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 762570002860 DXD motif; other site 762570002861 WbqC-like protein family; Region: WbqC; pfam08889 762570002862 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 762570002863 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762570002864 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762570002865 catalytic residue [active] 762570002866 Homeodomain-like domain; Region: HTH_23; pfam13384 762570002867 Winged helix-turn helix; Region: HTH_29; pfam13551 762570002868 Homeodomain-like domain; Region: HTH_32; pfam13565 762570002869 DDE superfamily endonuclease; Region: DDE_3; pfam13358 762570002870 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570002871 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762570002872 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570002873 Histidine kinase; Region: His_kinase; pfam06580 762570002874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570002875 ATP binding site [chemical binding]; other site 762570002876 Mg2+ binding site [ion binding]; other site 762570002877 G-X-G motif; other site 762570002878 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 762570002879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570002880 active site 762570002881 phosphorylation site [posttranslational modification] 762570002882 intermolecular recognition site; other site 762570002883 dimerization interface [polypeptide binding]; other site 762570002884 LytTr DNA-binding domain; Region: LytTR; smart00850 762570002885 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 762570002886 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 762570002887 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 762570002888 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 762570002889 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 762570002890 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 762570002891 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 762570002892 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 762570002893 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 762570002894 Peptidase family M28; Region: Peptidase_M28; pfam04389 762570002895 putative metal binding site [ion binding]; other site 762570002896 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 762570002897 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762570002898 Amidase; Region: Amidase; pfam01425 762570002899 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762570002900 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762570002901 DNA binding site [nucleotide binding] 762570002902 domain linker motif; other site 762570002903 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762570002904 ligand binding site [chemical binding]; other site 762570002905 dimerization interface [polypeptide binding]; other site 762570002906 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 762570002907 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 762570002908 active site 762570002909 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 762570002910 ligand binding site [chemical binding]; other site 762570002911 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570002912 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 762570002913 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 762570002914 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570002915 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570002916 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 762570002917 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570002918 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570002919 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570002920 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 762570002921 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 762570002922 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 762570002923 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 762570002924 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570002925 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 762570002926 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 762570002927 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570002928 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570002929 DNA binding residues [nucleotide binding] 762570002930 FecR protein; Region: FecR; pfam04773 762570002931 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762570002932 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570002933 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 762570002934 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 762570002935 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570002936 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 762570002937 starch binding outer membrane protein SusD; Region: SusD; cd08977 762570002938 SusD family; Region: SusD; pfam07980 762570002939 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 762570002940 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 762570002941 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 762570002942 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 762570002943 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 762570002944 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 762570002945 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 762570002946 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 762570002947 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 762570002948 hypothetical protein; Provisional; Region: PRK04164 762570002949 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 762570002950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570002951 PAS domain; Region: PAS_9; pfam13426 762570002952 putative active site [active] 762570002953 heme pocket [chemical binding]; other site 762570002954 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 762570002955 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 762570002956 cobalamin binding residues [chemical binding]; other site 762570002957 putative BtuC binding residues; other site 762570002958 dimer interface [polypeptide binding]; other site 762570002959 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 762570002960 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 762570002961 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762570002962 N-terminal plug; other site 762570002963 ligand-binding site [chemical binding]; other site 762570002964 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 762570002965 HsdM N-terminal domain; Region: HsdM_N; pfam12161 762570002966 Methyltransferase domain; Region: Methyltransf_26; pfam13659 762570002967 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 762570002968 Divergent AAA domain; Region: AAA_4; pfam04326 762570002969 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 762570002970 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 762570002971 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762570002972 Transposase IS200 like; Region: Y1_Tnp; cl00848 762570002973 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 762570002974 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 762570002975 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762570002976 ATP binding site [chemical binding]; other site 762570002977 putative Mg++ binding site [ion binding]; other site 762570002978 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 762570002979 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570002980 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 762570002981 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762570002982 N-terminal plug; other site 762570002983 ligand-binding site [chemical binding]; other site 762570002984 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 762570002985 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 762570002986 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 762570002987 substrate binding site; other site 762570002988 dimer interface; other site 762570002989 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 762570002990 homotrimer interaction site [polypeptide binding]; other site 762570002991 zinc binding site [ion binding]; other site 762570002992 CDP-binding sites; other site 762570002993 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 762570002994 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 762570002995 elongation factor Tu; Reviewed; Region: PRK00049 762570002996 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 762570002997 G1 box; other site 762570002998 GEF interaction site [polypeptide binding]; other site 762570002999 GTP/Mg2+ binding site [chemical binding]; other site 762570003000 Switch I region; other site 762570003001 G2 box; other site 762570003002 G3 box; other site 762570003003 Switch II region; other site 762570003004 G4 box; other site 762570003005 G5 box; other site 762570003006 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 762570003007 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 762570003008 Antibiotic Binding Site [chemical binding]; other site 762570003009 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 762570003010 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 762570003011 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 762570003012 putative homodimer interface [polypeptide binding]; other site 762570003013 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 762570003014 heterodimer interface [polypeptide binding]; other site 762570003015 homodimer interface [polypeptide binding]; other site 762570003016 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 762570003017 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 762570003018 23S rRNA interface [nucleotide binding]; other site 762570003019 L7/L12 interface [polypeptide binding]; other site 762570003020 putative thiostrepton binding site; other site 762570003021 L25 interface [polypeptide binding]; other site 762570003022 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 762570003023 mRNA/rRNA interface [nucleotide binding]; other site 762570003024 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 762570003025 23S rRNA interface [nucleotide binding]; other site 762570003026 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 762570003027 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 762570003028 core dimer interface [polypeptide binding]; other site 762570003029 peripheral dimer interface [polypeptide binding]; other site 762570003030 L10 interface [polypeptide binding]; other site 762570003031 L11 interface [polypeptide binding]; other site 762570003032 putative EF-Tu interaction site [polypeptide binding]; other site 762570003033 putative EF-G interaction site [polypeptide binding]; other site 762570003034 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 762570003035 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 762570003036 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 762570003037 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 762570003038 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 762570003039 RPB12 interaction site [polypeptide binding]; other site 762570003040 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 762570003041 RPB11 interaction site [polypeptide binding]; other site 762570003042 RPB12 interaction site [polypeptide binding]; other site 762570003043 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 762570003044 RPB12 interaction site [polypeptide binding]; other site 762570003045 RPB3 interaction site [polypeptide binding]; other site 762570003046 RPB1 interaction site [polypeptide binding]; other site 762570003047 RPB11 interaction site [polypeptide binding]; other site 762570003048 RPB10 interaction site [polypeptide binding]; other site 762570003049 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 762570003050 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 762570003051 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 762570003052 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 762570003053 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 762570003054 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 762570003055 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 762570003056 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 762570003057 DNA binding site [nucleotide binding] 762570003058 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 762570003059 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 762570003060 putative active site [active] 762570003061 Zn binding site [ion binding]; other site 762570003062 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 762570003063 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 762570003064 catalytic residues [active] 762570003065 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 762570003066 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 762570003067 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762570003068 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762570003069 Penicillin amidase; Region: Penicil_amidase; pfam01804 762570003070 hypothetical protein; Provisional; Region: PRK08609 762570003071 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 762570003072 metal binding triad [ion binding]; metal-binding site 762570003073 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 762570003074 active site 762570003075 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 762570003076 C-terminal peptidase (prc); Region: prc; TIGR00225 762570003077 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 762570003078 protein binding site [polypeptide binding]; other site 762570003079 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 762570003080 Catalytic dyad [active] 762570003081 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 762570003082 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 762570003083 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 762570003084 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 762570003085 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 762570003086 EamA-like transporter family; Region: EamA; pfam00892 762570003087 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 762570003088 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 762570003089 Probable Catalytic site; other site 762570003090 metal-binding site 762570003091 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 762570003092 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 762570003093 SLBB domain; Region: SLBB; pfam10531 762570003094 SLBB domain; Region: SLBB; pfam10531 762570003095 SLBB domain; Region: SLBB; pfam10531 762570003096 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 762570003097 SLBB domain; Region: SLBB; pfam10531 762570003098 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 762570003099 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 762570003100 thiamine phosphate binding site [chemical binding]; other site 762570003101 active site 762570003102 pyrophosphate binding site [ion binding]; other site 762570003103 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 762570003104 DHH family; Region: DHH; pfam01368 762570003105 DHHA1 domain; Region: DHHA1; pfam02272 762570003106 multifunctional aminopeptidase A; Provisional; Region: PRK00913 762570003107 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 762570003108 interface (dimer of trimers) [polypeptide binding]; other site 762570003109 Substrate-binding/catalytic site; other site 762570003110 Zn-binding sites [ion binding]; other site 762570003111 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762570003112 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762570003113 WHG domain; Region: WHG; pfam13305 762570003114 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 762570003115 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 762570003116 acyl-activating enzyme (AAE) consensus motif; other site 762570003117 putative AMP binding site [chemical binding]; other site 762570003118 putative active site [active] 762570003119 putative CoA binding site [chemical binding]; other site 762570003120 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 762570003121 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762570003122 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762570003123 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762570003124 substrate binding site [chemical binding]; other site 762570003125 oxyanion hole (OAH) forming residues; other site 762570003126 trimer interface [polypeptide binding]; other site 762570003127 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 762570003128 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762570003129 dimer interface [polypeptide binding]; other site 762570003130 active site 762570003131 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 762570003132 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762570003133 active site 762570003134 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 762570003135 Protein of unknown function (DUF433); Region: DUF433; pfam04255 762570003136 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 762570003137 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 762570003138 active site 762570003139 interdomain interaction site; other site 762570003140 putative metal-binding site [ion binding]; other site 762570003141 nucleotide binding site [chemical binding]; other site 762570003142 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 762570003143 domain I; other site 762570003144 phosphate binding site [ion binding]; other site 762570003145 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 762570003146 domain II; other site 762570003147 domain III; other site 762570003148 nucleotide binding site [chemical binding]; other site 762570003149 DNA binding groove [nucleotide binding] 762570003150 catalytic site [active] 762570003151 domain IV; other site 762570003152 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 762570003153 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 762570003154 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 762570003155 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 762570003156 Two component regulator propeller; Region: Reg_prop; pfam07494 762570003157 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 762570003158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762570003159 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cd00890 762570003160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570003161 dimer interface [polypeptide binding]; other site 762570003162 phosphorylation site [posttranslational modification] 762570003163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570003164 ATP binding site [chemical binding]; other site 762570003165 Mg2+ binding site [ion binding]; other site 762570003166 G-X-G motif; other site 762570003167 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 762570003168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570003169 active site 762570003170 phosphorylation site [posttranslational modification] 762570003171 intermolecular recognition site; other site 762570003172 dimerization interface [polypeptide binding]; other site 762570003173 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 762570003174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570003175 active site 762570003176 phosphorylation site [posttranslational modification] 762570003177 intermolecular recognition site; other site 762570003178 dimerization interface [polypeptide binding]; other site 762570003179 GTPase RsgA; Reviewed; Region: PRK00098 762570003180 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 762570003181 RNA binding site [nucleotide binding]; other site 762570003182 homodimer interface [polypeptide binding]; other site 762570003183 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 762570003184 GTPase/Zn-binding domain interface [polypeptide binding]; other site 762570003185 GTP/Mg2+ binding site [chemical binding]; other site 762570003186 G4 box; other site 762570003187 G5 box; other site 762570003188 G1 box; other site 762570003189 Switch I region; other site 762570003190 G2 box; other site 762570003191 G3 box; other site 762570003192 Switch II region; other site 762570003193 ABC transporter F family; Provisional; Region: PLN03073 762570003194 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 762570003195 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 762570003196 Found in ATP-dependent protease La (LON); Region: LON; smart00464 762570003197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570003198 Walker A motif; other site 762570003199 ATP binding site [chemical binding]; other site 762570003200 Walker B motif; other site 762570003201 arginine finger; other site 762570003202 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 762570003203 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 762570003204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 762570003205 dimer interface [polypeptide binding]; other site 762570003206 phosphorylation site [posttranslational modification] 762570003207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570003208 ATP binding site [chemical binding]; other site 762570003209 Mg2+ binding site [ion binding]; other site 762570003210 G-X-G motif; other site 762570003211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570003212 Response regulator receiver domain; Region: Response_reg; pfam00072 762570003213 active site 762570003214 phosphorylation site [posttranslational modification] 762570003215 intermolecular recognition site; other site 762570003216 dimerization interface [polypeptide binding]; other site 762570003217 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 762570003218 Predicted permeases [General function prediction only]; Region: COG0795 762570003219 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 762570003220 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 762570003221 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 762570003222 CoA-ligase; Region: Ligase_CoA; pfam00549 762570003223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762570003224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762570003225 Coenzyme A binding pocket [chemical binding]; other site 762570003226 BON domain; Region: BON; pfam04972 762570003227 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 762570003228 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 762570003229 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762570003230 nucleotide binding site [chemical binding]; other site 762570003231 Septum formation initiator; Region: DivIC; pfam04977 762570003232 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 762570003233 enolase; Provisional; Region: eno; PRK00077 762570003234 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 762570003235 dimer interface [polypeptide binding]; other site 762570003236 metal binding site [ion binding]; metal-binding site 762570003237 substrate binding pocket [chemical binding]; other site 762570003238 Tetratricopeptide repeat; Region: TPR_12; pfam13424 762570003239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570003240 binding surface 762570003241 TPR motif; other site 762570003242 TPR repeat; Region: TPR_11; pfam13414 762570003243 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 762570003244 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 762570003245 putative alpha-glucosidase; Provisional; Region: PRK10658 762570003246 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 762570003247 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 762570003248 trimer interface [polypeptide binding]; other site 762570003249 active site 762570003250 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 762570003251 catalytic site [active] 762570003252 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 762570003253 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 762570003254 active site 762570003255 nucleophile elbow; other site 762570003256 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 762570003257 hypothetical protein; Validated; Region: PRK07411 762570003258 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 762570003259 ATP binding site [chemical binding]; other site 762570003260 substrate interface [chemical binding]; other site 762570003261 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762570003262 active site residue [active] 762570003263 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 762570003264 MoaE interaction surface [polypeptide binding]; other site 762570003265 thiocarboxylated glycine; other site 762570003266 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 762570003267 MPN+ (JAMM) motif; other site 762570003268 Zinc-binding site [ion binding]; other site 762570003269 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 762570003270 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 762570003271 dimer interface [polypeptide binding]; other site 762570003272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570003273 catalytic residue [active] 762570003274 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 762570003275 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 762570003276 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 762570003277 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 762570003278 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 762570003279 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 762570003280 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 762570003281 putative CoA binding site [chemical binding]; other site 762570003282 putative trimer interface [polypeptide binding]; other site 762570003283 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 762570003284 putative trimer interface [polypeptide binding]; other site 762570003285 putative active site [active] 762570003286 putative substrate binding site [chemical binding]; other site 762570003287 putative CoA binding site [chemical binding]; other site 762570003288 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 762570003289 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 762570003290 active site residue [active] 762570003291 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 762570003292 active site residue [active] 762570003293 OsmC-like protein; Region: OsmC; pfam02566 762570003294 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 762570003295 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 762570003296 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 762570003297 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 762570003298 active site 762570003299 SAM binding site [chemical binding]; other site 762570003300 homodimer interface [polypeptide binding]; other site 762570003301 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 762570003302 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762570003303 homodimer interface [polypeptide binding]; other site 762570003304 substrate-cofactor binding pocket; other site 762570003305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570003306 catalytic residue [active] 762570003307 protoporphyrinogen oxidase; Region: PLN02576 762570003308 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762570003309 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 762570003310 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 762570003311 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 762570003312 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 762570003313 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 762570003314 trimer interface [polypeptide binding]; other site 762570003315 active site 762570003316 substrate binding site [chemical binding]; other site 762570003317 CoA binding site [chemical binding]; other site 762570003318 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 762570003319 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762570003320 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 762570003321 dimer interface [polypeptide binding]; other site 762570003322 active site 762570003323 catalytic residue [active] 762570003324 dihydrodipicolinate reductase; Provisional; Region: PRK00048 762570003325 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 762570003326 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 762570003327 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 762570003328 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 762570003329 nucleotide binding site [chemical binding]; other site 762570003330 substrate binding site [chemical binding]; other site 762570003331 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935 762570003332 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 762570003333 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 762570003334 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762570003335 catalytic residue [active] 762570003336 Acetyl-CoA acetyltransferase [Lipid metabolism]; Region: PaaJ; COG0183 762570003337 Protein of unknown function DUF99; Region: DUF99; pfam01949 762570003338 hypothetical protein; Provisional; Region: PRK00766 762570003339 NAD-dependent deacetylase; Provisional; Region: PRK05333 762570003340 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 762570003341 NAD+ binding site [chemical binding]; other site 762570003342 substrate binding site [chemical binding]; other site 762570003343 Zn binding site [ion binding]; other site 762570003344 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 762570003345 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 762570003346 Methyltransferase domain; Region: Methyltransf_23; pfam13489 762570003347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570003348 S-adenosylmethionine binding site [chemical binding]; other site 762570003349 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 762570003350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762570003351 Walker A/P-loop; other site 762570003352 ATP binding site [chemical binding]; other site 762570003353 Q-loop/lid; other site 762570003354 ABC transporter signature motif; other site 762570003355 Walker B; other site 762570003356 D-loop; other site 762570003357 H-loop/switch region; other site 762570003358 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 762570003359 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 762570003360 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 762570003361 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 762570003362 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762570003363 active site 762570003364 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 762570003365 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 762570003366 metal binding triad [ion binding]; metal-binding site 762570003367 Predicted transcriptional regulator [Transcription]; Region: COG2378 762570003368 HTH domain; Region: HTH_11; pfam08279 762570003369 WYL domain; Region: WYL; pfam13280 762570003370 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 762570003371 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 762570003372 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 762570003373 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 762570003374 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 762570003375 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 762570003376 toxin interface [polypeptide binding]; other site 762570003377 Zn binding site [ion binding]; other site 762570003378 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 762570003379 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 762570003380 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 762570003381 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 762570003382 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 762570003383 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 762570003384 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 762570003385 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 762570003386 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570003387 active site 762570003388 NTP binding site [chemical binding]; other site 762570003389 metal binding triad [ion binding]; metal-binding site 762570003390 antibiotic binding site [chemical binding]; other site 762570003391 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 762570003392 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 762570003393 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 762570003394 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839 762570003395 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 762570003396 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 762570003397 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 762570003398 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 762570003399 active site 762570003400 catalytic site [active] 762570003401 substrate binding site [chemical binding]; other site 762570003402 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 762570003403 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 762570003404 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 762570003405 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 762570003406 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 762570003407 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 762570003408 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 762570003409 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 762570003410 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762570003411 RNA binding site [nucleotide binding]; other site 762570003412 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 762570003413 CRISPR-associated protein, TIGR02710 family; Region: TIGR02710 762570003414 Domain of unknown function (DUF303); Region: DUF303; pfam03629 762570003415 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 762570003416 Domain of unknown function (DUF303); Region: DUF303; pfam03629 762570003417 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 762570003418 GYD domain; Region: GYD; cl01743 762570003419 argininosuccinate lyase; Provisional; Region: PRK00855 762570003420 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 762570003421 active sites [active] 762570003422 tetramer interface [polypeptide binding]; other site 762570003423 CHASE3 domain; Region: CHASE3; pfam05227 762570003424 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762570003425 dimerization interface [polypeptide binding]; other site 762570003426 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 762570003427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762570003428 dimerization interface [polypeptide binding]; other site 762570003429 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762570003430 dimer interface [polypeptide binding]; other site 762570003431 putative CheW interface [polypeptide binding]; other site 762570003432 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 762570003433 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 762570003434 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 762570003435 metal binding site [ion binding]; metal-binding site 762570003436 dimer interface [polypeptide binding]; other site 762570003437 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 762570003438 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762570003439 RNA binding surface [nucleotide binding]; other site 762570003440 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 762570003441 active site 762570003442 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 762570003443 active site 762570003444 phosphorylation site [posttranslational modification] 762570003445 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 762570003446 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 762570003447 dimer interface [polypeptide binding]; other site 762570003448 motif 1; other site 762570003449 active site 762570003450 motif 2; other site 762570003451 motif 3; other site 762570003452 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 762570003453 anticodon binding site; other site 762570003454 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 762570003455 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 762570003456 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 762570003457 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 762570003458 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 762570003459 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 762570003460 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 762570003461 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762570003462 ligand binding site [chemical binding]; other site 762570003463 flexible hinge region; other site 762570003464 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 762570003465 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 762570003466 metal binding triad; other site 762570003467 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 762570003468 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570003469 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570003470 DNA binding residues [nucleotide binding] 762570003471 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 762570003472 catalytic nucleophile [active] 762570003473 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 762570003474 E-class dimer interface [polypeptide binding]; other site 762570003475 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 762570003476 P-class dimer interface [polypeptide binding]; other site 762570003477 active site 762570003478 Cu2+ binding site [ion binding]; other site 762570003479 Zn2+ binding site [ion binding]; other site 762570003480 putative peptidase; Provisional; Region: PRK11649 762570003481 Peptidase family M23; Region: Peptidase_M23; pfam01551 762570003482 agmatinase; Region: agmatinase; TIGR01230 762570003483 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 762570003484 putative active site [active] 762570003485 putative metal binding site [ion binding]; other site 762570003486 imidazolonepropionase; Validated; Region: PRK09356 762570003487 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 762570003488 active site 762570003489 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 762570003490 active sites [active] 762570003491 tetramer interface [polypeptide binding]; other site 762570003492 urocanate hydratase; Provisional; Region: PRK05414 762570003493 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 762570003494 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 762570003495 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 762570003496 Walker A/P-loop; other site 762570003497 ATP binding site [chemical binding]; other site 762570003498 Q-loop/lid; other site 762570003499 ABC transporter signature motif; other site 762570003500 Walker B; other site 762570003501 D-loop; other site 762570003502 H-loop/switch region; other site 762570003503 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 762570003504 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 762570003505 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 762570003506 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 762570003507 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 762570003508 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 762570003509 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 762570003510 active site 762570003511 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 762570003512 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762570003513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762570003514 catalytic residue [active] 762570003515 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 762570003516 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 762570003517 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 762570003518 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 762570003519 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 762570003520 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 762570003521 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 762570003522 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 762570003523 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 762570003524 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 762570003525 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 762570003526 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 762570003527 substrate binding site [chemical binding]; other site 762570003528 glutamase interaction surface [polypeptide binding]; other site 762570003529 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 762570003530 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 762570003531 catalytic residues [active] 762570003532 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 762570003533 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 762570003534 putative active site [active] 762570003535 oxyanion strand; other site 762570003536 catalytic triad [active] 762570003537 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 762570003538 pyrroline-5-carboxylate reductase; Region: PLN02688 762570003539 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 762570003540 putative active site pocket [active] 762570003541 4-fold oligomerization interface [polypeptide binding]; other site 762570003542 metal binding residues [ion binding]; metal-binding site 762570003543 3-fold/trimer interface [polypeptide binding]; other site 762570003544 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 762570003545 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 762570003546 active site 762570003547 HIGH motif; other site 762570003548 KMSKS motif; other site 762570003549 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 762570003550 tRNA binding surface [nucleotide binding]; other site 762570003551 anticodon binding site; other site 762570003552 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 762570003553 dimer interface [polypeptide binding]; other site 762570003554 putative tRNA-binding site [nucleotide binding]; other site 762570003555 Herpesvirus UL37 tegument protein; Region: Herpes_UL37_1; cl17798 762570003556 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 762570003557 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 762570003558 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 762570003559 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 762570003560 D-pathway; other site 762570003561 Low-spin heme binding site [chemical binding]; other site 762570003562 Putative water exit pathway; other site 762570003563 Binuclear center (active site) [active] 762570003564 K-pathway; other site 762570003565 Putative proton exit pathway; other site 762570003566 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570003567 active site 762570003568 NTP binding site [chemical binding]; other site 762570003569 metal binding triad [ion binding]; metal-binding site 762570003570 antibiotic binding site [chemical binding]; other site 762570003571 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 762570003572 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 762570003573 motif 1; other site 762570003574 active site 762570003575 motif 2; other site 762570003576 motif 3; other site 762570003577 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 762570003578 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 762570003579 putative active site [active] 762570003580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 762570003581 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 762570003582 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 762570003583 substrate binding site [chemical binding]; other site 762570003584 dimer interface [polypeptide binding]; other site 762570003585 NADP binding site [chemical binding]; other site 762570003586 catalytic residues [active] 762570003587 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762570003588 active site 2 [active] 762570003589 active site 1 [active] 762570003590 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 762570003591 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762570003592 putative trimer interface [polypeptide binding]; other site 762570003593 putative CoA binding site [chemical binding]; other site 762570003594 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 762570003595 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762570003596 dimer interface [polypeptide binding]; other site 762570003597 active site 762570003598 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762570003599 CoenzymeA binding site [chemical binding]; other site 762570003600 subunit interaction site [polypeptide binding]; other site 762570003601 PHB binding site; other site 762570003602 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 762570003603 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762570003604 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762570003605 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762570003606 enoyl-CoA hydratase; Provisional; Region: PRK08140 762570003607 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762570003608 substrate binding site [chemical binding]; other site 762570003609 oxyanion hole (OAH) forming residues; other site 762570003610 trimer interface [polypeptide binding]; other site 762570003611 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762570003612 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 762570003613 substrate binding site [chemical binding]; other site 762570003614 oxyanion hole (OAH) forming residues; other site 762570003615 trimer interface [polypeptide binding]; other site 762570003616 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 762570003617 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762570003618 tetramer interface [polypeptide binding]; other site 762570003619 TPP-binding site [chemical binding]; other site 762570003620 heterodimer interface [polypeptide binding]; other site 762570003621 phosphorylation loop region [posttranslational modification] 762570003622 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762570003623 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762570003624 alpha subunit interface [polypeptide binding]; other site 762570003625 TPP binding site [chemical binding]; other site 762570003626 heterodimer interface [polypeptide binding]; other site 762570003627 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762570003628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762570003629 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 762570003630 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 762570003631 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 762570003632 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 762570003633 Phenylacetic acid degradation B; Region: PaaB; cl01371 762570003634 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 762570003635 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 762570003636 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 762570003637 MutS domain I; Region: MutS_I; pfam01624 762570003638 MutS domain II; Region: MutS_II; pfam05188 762570003639 MutS domain III; Region: MutS_III; pfam05192 762570003640 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 762570003641 Walker A/P-loop; other site 762570003642 ATP binding site [chemical binding]; other site 762570003643 Q-loop/lid; other site 762570003644 ABC transporter signature motif; other site 762570003645 Walker B; other site 762570003646 D-loop; other site 762570003647 H-loop/switch region; other site 762570003648 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 762570003649 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 762570003650 trimer interface [polypeptide binding]; other site 762570003651 putative metal binding site [ion binding]; other site 762570003652 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 762570003653 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 762570003654 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 762570003655 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 762570003656 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 762570003657 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 762570003658 ABC1 family; Region: ABC1; cl17513 762570003659 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 762570003660 active site 762570003661 ATP binding site [chemical binding]; other site 762570003662 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 762570003663 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 762570003664 hinge; other site 762570003665 active site 762570003666 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 762570003667 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 762570003668 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762570003669 catalytic residue [active] 762570003670 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 762570003671 AMP binding site [chemical binding]; other site 762570003672 metal binding site [ion binding]; metal-binding site 762570003673 active site 762570003674 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 762570003675 glucose/galactose transporter; Region: gluP; TIGR01272 762570003676 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 762570003677 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 762570003678 active site 762570003679 trimer interface [polypeptide binding]; other site 762570003680 allosteric site; other site 762570003681 active site lid [active] 762570003682 hexamer (dimer of trimers) interface [polypeptide binding]; other site 762570003683 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 762570003684 Helix-turn-helix domain; Region: HTH_25; pfam13413 762570003685 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 762570003686 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 762570003687 nucleotide binding pocket [chemical binding]; other site 762570003688 K-X-D-G motif; other site 762570003689 catalytic site [active] 762570003690 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 762570003691 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 762570003692 Helix-hairpin-helix motif; Region: HHH; pfam00633 762570003693 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 762570003694 Dimer interface [polypeptide binding]; other site 762570003695 BRCT sequence motif; other site 762570003696 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 762570003697 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 762570003698 Probable transposase; Region: OrfB_IS605; pfam01385 762570003699 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 762570003700 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 762570003701 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 762570003702 Na binding site [ion binding]; other site 762570003703 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 762570003704 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 762570003705 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762570003706 Zn2+ binding site [ion binding]; other site 762570003707 Mg2+ binding site [ion binding]; other site 762570003708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762570003709 DNA-binding site [nucleotide binding]; DNA binding site 762570003710 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 762570003711 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 762570003712 Glutamate binding site [chemical binding]; other site 762570003713 NAD binding site [chemical binding]; other site 762570003714 catalytic residues [active] 762570003715 adenylate kinase; Reviewed; Region: adk; PRK00279 762570003716 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 762570003717 AMP-binding site [chemical binding]; other site 762570003718 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 762570003719 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 762570003720 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 762570003721 substrate binding pocket [chemical binding]; other site 762570003722 chain length determination region; other site 762570003723 substrate-Mg2+ binding site; other site 762570003724 catalytic residues [active] 762570003725 aspartate-rich region 1; other site 762570003726 active site lid residues [active] 762570003727 aspartate-rich region 2; other site 762570003728 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 762570003729 dimerization domain swap beta strand [polypeptide binding]; other site 762570003730 regulatory protein interface [polypeptide binding]; other site 762570003731 active site 762570003732 regulatory phosphorylation site [posttranslational modification]; other site 762570003733 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 762570003734 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 762570003735 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 762570003736 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 762570003737 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 762570003738 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 762570003739 dimer interface [polypeptide binding]; other site 762570003740 active site 762570003741 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 762570003742 dimer interface [polypeptide binding]; other site 762570003743 active site 762570003744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762570003745 active site 762570003746 motif I; other site 762570003747 motif II; other site 762570003748 membrane glycoprotein; Provisional; Region: PHA03332 762570003749 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 762570003750 dimer interface [polypeptide binding]; other site 762570003751 Alkaline phosphatase homologues; Region: alkPPc; smart00098 762570003752 active site 762570003753 hypothetical protein; Validated; Region: PRK07883 762570003754 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 762570003755 active site 762570003756 catalytic site [active] 762570003757 substrate binding site [chemical binding]; other site 762570003758 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 762570003759 GIY-YIG motif/motif A; other site 762570003760 active site 762570003761 catalytic site [active] 762570003762 putative DNA binding site [nucleotide binding]; other site 762570003763 metal binding site [ion binding]; metal-binding site 762570003764 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 762570003765 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762570003766 HD domain; Region: HD; pfam01966 762570003767 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 762570003768 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 762570003769 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 762570003770 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 762570003771 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 762570003772 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 762570003773 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 762570003774 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 762570003775 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 762570003776 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 762570003777 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 762570003778 aromatic arch; other site 762570003779 DCoH dimer interaction site [polypeptide binding]; other site 762570003780 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 762570003781 DCoH tetramer interaction site [polypeptide binding]; other site 762570003782 substrate binding site [chemical binding]; other site 762570003783 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 762570003784 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 762570003785 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 762570003786 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 762570003787 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 762570003788 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 762570003789 GIY-YIG motif/motif A; other site 762570003790 active site 762570003791 catalytic site [active] 762570003792 putative DNA binding site [nucleotide binding]; other site 762570003793 metal binding site [ion binding]; metal-binding site 762570003794 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 762570003795 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 762570003796 DNA binding site [nucleotide binding] 762570003797 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 762570003798 putative active site [active] 762570003799 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 762570003800 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 762570003801 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 762570003802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762570003803 Walker A/P-loop; other site 762570003804 ATP binding site [chemical binding]; other site 762570003805 Q-loop/lid; other site 762570003806 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 762570003807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762570003808 ABC transporter signature motif; other site 762570003809 Walker B; other site 762570003810 D-loop; other site 762570003811 H-loop/switch region; other site 762570003812 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762570003813 EamA-like transporter family; Region: EamA; pfam00892 762570003814 EamA-like transporter family; Region: EamA; pfam00892 762570003815 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 762570003816 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 762570003817 DNA binding residues [nucleotide binding] 762570003818 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 762570003819 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 762570003820 active site 762570003821 dimer interface [polypeptide binding]; other site 762570003822 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 762570003823 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 762570003824 active site 762570003825 FMN binding site [chemical binding]; other site 762570003826 substrate binding site [chemical binding]; other site 762570003827 3Fe-4S cluster binding site [ion binding]; other site 762570003828 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 762570003829 domain interface; other site 762570003830 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 762570003831 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762570003832 homoserine kinase; Provisional; Region: PRK01212 762570003833 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 762570003834 threonine synthase; Validated; Region: PRK09225 762570003835 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 762570003836 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762570003837 catalytic residue [active] 762570003838 enoyl-CoA hydratase; Provisional; Region: PRK05995 762570003839 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762570003840 substrate binding site [chemical binding]; other site 762570003841 oxyanion hole (OAH) forming residues; other site 762570003842 trimer interface [polypeptide binding]; other site 762570003843 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 762570003844 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 762570003845 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 762570003846 dimerization interface [polypeptide binding]; other site 762570003847 putative ATP binding site [chemical binding]; other site 762570003848 membrane protein; Provisional; Region: PRK14410 762570003849 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 762570003850 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 762570003851 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 762570003852 Divergent AAA domain; Region: AAA_4; pfam04326 762570003853 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 762570003854 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 762570003855 CAP-like domain; other site 762570003856 active site 762570003857 primary dimer interface [polypeptide binding]; other site 762570003858 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762570003859 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762570003860 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 762570003861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570003862 ATP binding site [chemical binding]; other site 762570003863 Mg2+ binding site [ion binding]; other site 762570003864 G-X-G motif; other site 762570003865 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 762570003866 anchoring element; other site 762570003867 dimer interface [polypeptide binding]; other site 762570003868 ATP binding site [chemical binding]; other site 762570003869 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 762570003870 active site 762570003871 putative metal-binding site [ion binding]; other site 762570003872 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 762570003873 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762570003874 EamA-like transporter family; Region: EamA; pfam00892 762570003875 EamA-like transporter family; Region: EamA; pfam00892 762570003876 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 762570003877 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762570003878 ABC-ATPase subunit interface; other site 762570003879 dimer interface [polypeptide binding]; other site 762570003880 putative PBP binding regions; other site 762570003881 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 762570003882 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762570003883 ABC-ATPase subunit interface; other site 762570003884 dimer interface [polypeptide binding]; other site 762570003885 putative PBP binding regions; other site 762570003886 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 762570003887 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 762570003888 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 762570003889 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 762570003890 intersubunit interface [polypeptide binding]; other site 762570003891 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 762570003892 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 762570003893 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 762570003894 FeoA domain; Region: FeoA; pfam04023 762570003895 CHRD domain; Region: CHRD; pfam07452 762570003896 CHRD domain; Region: CHRD; pfam07452 762570003897 CHRD domain; Region: CHRD; pfam07452 762570003898 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570003899 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762570003900 catalytic residues [active] 762570003901 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 762570003902 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 762570003903 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 762570003904 FAD binding pocket [chemical binding]; other site 762570003905 FAD binding motif [chemical binding]; other site 762570003906 phosphate binding motif [ion binding]; other site 762570003907 beta-alpha-beta structure motif; other site 762570003908 NAD binding pocket [chemical binding]; other site 762570003909 MoxR-like ATPases [General function prediction only]; Region: COG0714 762570003910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570003911 Walker A motif; other site 762570003912 ATP binding site [chemical binding]; other site 762570003913 Walker B motif; other site 762570003914 arginine finger; other site 762570003915 SurA N-terminal domain; Region: SurA_N; pfam09312 762570003916 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 762570003917 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 762570003918 SurA N-terminal domain; Region: SurA_N_3; cl07813 762570003919 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 762570003920 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 762570003921 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 762570003922 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 762570003923 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 762570003924 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 762570003925 HIGH motif; other site 762570003926 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 762570003927 active site 762570003928 KMSKS motif; other site 762570003929 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 762570003930 cytidylate kinase; Provisional; Region: cmk; PRK00023 762570003931 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 762570003932 CMP-binding site; other site 762570003933 The sites determining sugar specificity; other site 762570003934 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 762570003935 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 762570003936 RNA binding site [nucleotide binding]; other site 762570003937 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 762570003938 RNA binding site [nucleotide binding]; other site 762570003939 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 762570003940 RNA binding site [nucleotide binding]; other site 762570003941 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 762570003942 RNA binding site [nucleotide binding]; other site 762570003943 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762570003944 RNA binding site [nucleotide binding]; other site 762570003945 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 762570003946 RNA binding site [nucleotide binding]; other site 762570003947 HD supefamily hydrolase [General function prediction only]; Region: COG3294 762570003948 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 762570003949 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 762570003950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570003951 catalytic residue [active] 762570003952 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 762570003953 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 762570003954 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 762570003955 putative dimer interface [polypeptide binding]; other site 762570003956 Nrap protein; Region: Nrap; pfam03813 762570003957 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 762570003958 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 762570003959 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 762570003960 active site 762570003961 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 762570003962 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 762570003963 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 762570003964 TrkA-N domain; Region: TrkA_N; pfam02254 762570003965 TrkA-C domain; Region: TrkA_C; pfam02080 762570003966 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 762570003967 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762570003968 NAD binding site [chemical binding]; other site 762570003969 catalytic residues [active] 762570003970 hypothetical protein; Validated; Region: PRK07682 762570003971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762570003972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570003973 homodimer interface [polypeptide binding]; other site 762570003974 catalytic residue [active] 762570003975 peptide chain release factor 2; Validated; Region: prfB; PRK00578 762570003976 This domain is found in peptide chain release factors; Region: PCRF; smart00937 762570003977 RF-1 domain; Region: RF-1; pfam00472 762570003978 L-aspartate oxidase; Region: PLN02815 762570003979 L-aspartate oxidase; Provisional; Region: PRK06175 762570003980 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 762570003981 ribosome maturation protein RimP; Reviewed; Region: PRK00092 762570003982 Sm and related proteins; Region: Sm_like; cl00259 762570003983 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 762570003984 putative oligomer interface [polypeptide binding]; other site 762570003985 putative RNA binding site [nucleotide binding]; other site 762570003986 transcription termination factor NusA; Region: NusA; TIGR01953 762570003987 NusA N-terminal domain; Region: NusA_N; pfam08529 762570003988 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 762570003989 RNA binding site [nucleotide binding]; other site 762570003990 homodimer interface [polypeptide binding]; other site 762570003991 NusA-like KH domain; Region: KH_5; pfam13184 762570003992 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 762570003993 G-X-X-G motif; other site 762570003994 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 762570003995 translation initiation factor IF-2; Region: IF-2; TIGR00487 762570003996 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 762570003997 G1 box; other site 762570003998 putative GEF interaction site [polypeptide binding]; other site 762570003999 GTP/Mg2+ binding site [chemical binding]; other site 762570004000 Switch I region; other site 762570004001 G2 box; other site 762570004002 G3 box; other site 762570004003 Switch II region; other site 762570004004 G4 box; other site 762570004005 G5 box; other site 762570004006 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 762570004007 Translation-initiation factor 2; Region: IF-2; pfam11987 762570004008 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 762570004009 Ribosome-binding factor A; Region: RBFA; pfam02033 762570004010 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 762570004011 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 762570004012 RNA binding site [nucleotide binding]; other site 762570004013 active site 762570004014 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 762570004015 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 762570004016 active site 762570004017 Riboflavin kinase; Region: Flavokinase; pfam01687 762570004018 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 762570004019 16S/18S rRNA binding site [nucleotide binding]; other site 762570004020 S13e-L30e interaction site [polypeptide binding]; other site 762570004021 25S rRNA binding site [nucleotide binding]; other site 762570004022 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 762570004023 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 762570004024 RNase E interface [polypeptide binding]; other site 762570004025 trimer interface [polypeptide binding]; other site 762570004026 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 762570004027 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 762570004028 RNase E interface [polypeptide binding]; other site 762570004029 trimer interface [polypeptide binding]; other site 762570004030 active site 762570004031 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 762570004032 putative nucleic acid binding region [nucleotide binding]; other site 762570004033 G-X-X-G motif; other site 762570004034 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 762570004035 RNA binding site [nucleotide binding]; other site 762570004036 domain interface; other site 762570004037 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762570004038 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 762570004039 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762570004040 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 762570004041 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 762570004042 NAD binding site [chemical binding]; other site 762570004043 substrate binding site [chemical binding]; other site 762570004044 homodimer interface [polypeptide binding]; other site 762570004045 active site 762570004046 ScpA/B protein; Region: ScpA_ScpB; cl00598 762570004047 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 762570004048 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762570004049 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 762570004050 RNA binding surface [nucleotide binding]; other site 762570004051 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 762570004052 active site 762570004053 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 762570004054 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 762570004055 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 762570004056 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 762570004057 active site 762570004058 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762570004059 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762570004060 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 762570004061 active site 762570004062 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 762570004063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570004064 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 762570004065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570004066 ATP binding site [chemical binding]; other site 762570004067 Mg2+ binding site [ion binding]; other site 762570004068 G-X-G motif; other site 762570004069 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 762570004070 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 762570004071 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 762570004072 oligomeric interface; other site 762570004073 putative active site [active] 762570004074 homodimer interface [polypeptide binding]; other site 762570004075 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 762570004076 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762570004077 active site 762570004078 DNA binding site [nucleotide binding] 762570004079 Int/Topo IB signature motif; other site 762570004080 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762570004081 active site 2 [active] 762570004082 active site 1 [active] 762570004083 SWIM zinc finger; Region: SWIM; pfam04434 762570004084 Uncharacterized conserved protein [Function unknown]; Region: COG4715 762570004085 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 762570004086 HicB family; Region: HicB; pfam05534 762570004087 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 762570004088 Probable transposase; Region: OrfB_IS605; pfam01385 762570004089 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 762570004090 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 762570004091 PIN domain; Region: PIN_3; pfam13470 762570004092 Predicted transcriptional regulator [Transcription]; Region: COG3905 762570004093 Predicted transcriptional regulator [Transcription]; Region: COG2378 762570004094 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762570004095 putative DNA binding site [nucleotide binding]; other site 762570004096 putative Zn2+ binding site [ion binding]; other site 762570004097 WYL domain; Region: WYL; pfam13280 762570004098 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 762570004099 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 762570004100 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762570004101 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762570004102 DNA binding site [nucleotide binding] 762570004103 domain linker motif; other site 762570004104 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762570004105 dimerization interface [polypeptide binding]; other site 762570004106 ligand binding site [chemical binding]; other site 762570004107 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 762570004108 active site 762570004109 ATP binding site [chemical binding]; other site 762570004110 substrate binding site [chemical binding]; other site 762570004111 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762570004112 Pyrococcus horikoshii Ph0642 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Ph0642_like; cd07577 762570004113 putative active site [active] 762570004114 catalytic triad [active] 762570004115 dimer interface [polypeptide binding]; other site 762570004116 putative tetramer interface [polypeptide binding]; other site 762570004117 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 762570004118 MoaE homodimer interface [polypeptide binding]; other site 762570004119 MoaD interaction [polypeptide binding]; other site 762570004120 active site residues [active] 762570004121 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 762570004122 MoaE interaction surface [polypeptide binding]; other site 762570004123 MoeB interaction surface [polypeptide binding]; other site 762570004124 thiocarboxylated glycine; other site 762570004125 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 762570004126 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762570004127 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 762570004128 active site 762570004129 catalytic motif [active] 762570004130 Zn binding site [ion binding]; other site 762570004131 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 762570004132 active site 762570004133 catalytic motif [active] 762570004134 Zn binding site [ion binding]; other site 762570004135 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 762570004136 metal ion-dependent adhesion site (MIDAS); other site 762570004137 CARDB; Region: CARDB; pfam07705 762570004138 Lamin Tail Domain; Region: LTD; pfam00932 762570004139 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 762570004140 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 762570004141 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 762570004142 Clp amino terminal domain; Region: Clp_N; pfam02861 762570004143 Clp amino terminal domain; Region: Clp_N; pfam02861 762570004144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570004145 Walker A motif; other site 762570004146 ATP binding site [chemical binding]; other site 762570004147 Walker B motif; other site 762570004148 arginine finger; other site 762570004149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570004150 Walker A motif; other site 762570004151 ATP binding site [chemical binding]; other site 762570004152 Walker B motif; other site 762570004153 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762570004154 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 762570004155 active site 762570004156 dimer interface [polypeptide binding]; other site 762570004157 catalytic nucleophile [active] 762570004158 Probable transposase; Region: OrfB_IS605; pfam01385 762570004159 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 762570004160 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 762570004161 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762570004162 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 762570004163 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762570004164 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762570004165 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 762570004166 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762570004167 DNA polymerase I; Provisional; Region: PRK05755 762570004168 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 762570004169 active site 762570004170 metal binding site 1 [ion binding]; metal-binding site 762570004171 putative 5' ssDNA interaction site; other site 762570004172 metal binding site 3; metal-binding site 762570004173 metal binding site 2 [ion binding]; metal-binding site 762570004174 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 762570004175 putative DNA binding site [nucleotide binding]; other site 762570004176 putative metal binding site [ion binding]; other site 762570004177 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 762570004178 active site 762570004179 catalytic site [active] 762570004180 substrate binding site [chemical binding]; other site 762570004181 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 762570004182 active site 762570004183 DNA binding site [nucleotide binding] 762570004184 catalytic site [active] 762570004185 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 762570004186 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 762570004187 NAD binding site [chemical binding]; other site 762570004188 substrate binding site [chemical binding]; other site 762570004189 homodimer interface [polypeptide binding]; other site 762570004190 active site 762570004191 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 762570004192 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762570004193 active site 762570004194 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 762570004195 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 762570004196 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762570004197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762570004198 motif II; other site 762570004199 Fructosamine kinase; Region: Fructosamin_kin; cl17579 762570004200 Phosphotransferase enzyme family; Region: APH; pfam01636 762570004201 Low molecular weight phosphatase family; Region: LMWPc; cd00115 762570004202 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 762570004203 active site 762570004204 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 762570004205 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 762570004206 generic binding surface I; other site 762570004207 generic binding surface II; other site 762570004208 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 762570004209 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 762570004210 Ligand Binding Site [chemical binding]; other site 762570004211 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 762570004212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762570004213 FeS/SAM binding site; other site 762570004214 HemN C-terminal domain; Region: HemN_C; pfam06969 762570004215 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570004216 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 762570004217 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 762570004218 DNA polymerase II large subunit; Validated; Region: PRK04023 762570004219 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570004220 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762570004221 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570004222 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570004223 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 762570004224 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: PurL; COG0047 762570004225 catalytic triad [active] 762570004226 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762570004227 Cytochrome c; Region: Cytochrom_C; pfam00034 762570004228 MOSC domain; Region: MOSC; pfam03473 762570004229 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 762570004230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762570004231 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 762570004232 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 762570004233 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762570004234 dimerization interface [polypeptide binding]; other site 762570004235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570004236 dimer interface [polypeptide binding]; other site 762570004237 phosphorylation site [posttranslational modification] 762570004238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570004239 ATP binding site [chemical binding]; other site 762570004240 Mg2+ binding site [ion binding]; other site 762570004241 G-X-G motif; other site 762570004242 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762570004243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570004244 active site 762570004245 phosphorylation site [posttranslational modification] 762570004246 intermolecular recognition site; other site 762570004247 dimerization interface [polypeptide binding]; other site 762570004248 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762570004249 DNA binding site [nucleotide binding] 762570004250 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 762570004251 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 762570004252 Multicopper oxidase; Region: Cu-oxidase; pfam00394 762570004253 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 762570004254 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 762570004255 Predicted metal-binding protein [General function prediction only]; Region: COG3019 762570004256 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 762570004257 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762570004258 catalytic residues [active] 762570004259 Short C-terminal domain; Region: SHOCT; pfam09851 762570004260 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 762570004261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570004262 S-adenosylmethionine binding site [chemical binding]; other site 762570004263 Domain of unknown function DUF302; Region: DUF302; pfam03625 762570004264 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 762570004265 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762570004266 Zn binding site [ion binding]; other site 762570004267 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 762570004268 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762570004269 Zn binding site [ion binding]; other site 762570004270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762570004271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762570004272 putative substrate translocation pore; other site 762570004273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762570004274 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762570004275 metal-binding site [ion binding] 762570004276 mercuric reductase; Region: MerA; TIGR02053 762570004277 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 762570004278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762570004279 NAD binding site [chemical binding]; other site 762570004280 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762570004281 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762570004282 metal-binding site [ion binding] 762570004283 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762570004284 dimerization interface [polypeptide binding]; other site 762570004285 putative DNA binding site [nucleotide binding]; other site 762570004286 putative Zn2+ binding site [ion binding]; other site 762570004287 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 762570004288 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 762570004289 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 762570004290 active site 762570004291 Zn binding site [ion binding]; other site 762570004292 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 762570004293 30S subunit binding site; other site 762570004294 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762570004295 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762570004296 active site 762570004297 metal binding site [ion binding]; metal-binding site 762570004298 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 762570004299 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762570004300 E3 interaction surface; other site 762570004301 lipoyl attachment site [posttranslational modification]; other site 762570004302 e3 binding domain; Region: E3_binding; pfam02817 762570004303 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 762570004304 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762570004305 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762570004306 alpha subunit interface [polypeptide binding]; other site 762570004307 TPP binding site [chemical binding]; other site 762570004308 heterodimer interface [polypeptide binding]; other site 762570004309 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762570004310 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 762570004311 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762570004312 tetramer interface [polypeptide binding]; other site 762570004313 TPP-binding site [chemical binding]; other site 762570004314 heterodimer interface [polypeptide binding]; other site 762570004315 phosphorylation loop region [posttranslational modification] 762570004316 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 762570004317 Ligand binding site; other site 762570004318 Putative Catalytic site; other site 762570004319 DXD motif; other site 762570004320 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 762570004321 putative active site [active] 762570004322 putative metal binding site [ion binding]; other site 762570004323 isocitrate dehydrogenase; Validated; Region: PRK07362 762570004324 isocitrate dehydrogenase; Reviewed; Region: PRK07006 762570004325 Domain of unknown function (DUF3524); Region: DUF3524; pfam12038 762570004326 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570004327 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762570004328 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 762570004329 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 762570004330 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 762570004331 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762570004332 ATP binding site [chemical binding]; other site 762570004333 putative Mg++ binding site [ion binding]; other site 762570004334 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 762570004335 Abortive infection C-terminus; Region: Abi_C; pfam14355 762570004336 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 762570004337 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 762570004338 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 762570004339 AAA domain; Region: AAA_13; pfam13166 762570004340 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 762570004341 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762570004342 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762570004343 HsdM N-terminal domain; Region: HsdM_N; pfam12161 762570004344 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 762570004345 Methyltransferase domain; Region: Methyltransf_26; pfam13659 762570004346 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 762570004347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762570004348 Walker A/P-loop; other site 762570004349 ATP binding site [chemical binding]; other site 762570004350 Q-loop/lid; other site 762570004351 ABC transporter signature motif; other site 762570004352 Walker B; other site 762570004353 D-loop; other site 762570004354 H-loop/switch region; other site 762570004355 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785 762570004356 DNA polymerase type-B family; Region: POLBc; smart00486 762570004357 active site 762570004358 catalytic site [active] 762570004359 substrate binding site [chemical binding]; other site 762570004360 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 762570004361 active site 762570004362 metal-binding site 762570004363 arginine decarboxylase; Provisional; Region: PRK05354 762570004364 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 762570004365 dimer interface [polypeptide binding]; other site 762570004366 active site 762570004367 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762570004368 catalytic residues [active] 762570004369 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 762570004370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 762570004371 intermolecular recognition site; other site 762570004372 active site 762570004373 dimerization interface [polypeptide binding]; other site 762570004374 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 762570004375 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 762570004376 PA/protease or protease-like domain interface [polypeptide binding]; other site 762570004377 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 762570004378 Peptidase family M28; Region: Peptidase_M28; pfam04389 762570004379 metal binding site [ion binding]; metal-binding site 762570004380 Protein of unknown function (DUF429); Region: DUF429; cl12046 762570004381 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 762570004382 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 762570004383 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 762570004384 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 762570004385 NADP binding site [chemical binding]; other site 762570004386 dimer interface [polypeptide binding]; other site 762570004387 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 762570004388 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762570004389 active site 762570004390 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 762570004391 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762570004392 active site 762570004393 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 762570004394 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 762570004395 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 762570004396 dimer interface [polypeptide binding]; other site 762570004397 ADP-ribose binding site [chemical binding]; other site 762570004398 active site 762570004399 nudix motif; other site 762570004400 metal binding site [ion binding]; metal-binding site 762570004401 methionine sulfoxide reductase B; Provisional; Region: PRK00222 762570004402 SelR domain; Region: SelR; pfam01641 762570004403 acetyl-CoA synthetase; Provisional; Region: PRK00174 762570004404 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 762570004405 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 762570004406 acyl-activating enzyme (AAE) consensus motif; other site 762570004407 putative AMP binding site [chemical binding]; other site 762570004408 putative active site [active] 762570004409 putative CoA binding site [chemical binding]; other site 762570004410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570004411 TPR motif; other site 762570004412 Tetratricopeptide repeat; Region: TPR_16; pfam13432 762570004413 binding surface 762570004414 Tetratricopeptide repeat; Region: TPR_16; pfam13432 762570004415 Family description; Region: VCBS; pfam13517 762570004416 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 762570004417 Probable transposase; Region: OrfB_IS605; pfam01385 762570004418 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 762570004419 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 762570004420 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 762570004421 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 762570004422 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 762570004423 Ligand binding site [chemical binding]; other site 762570004424 Electron transfer flavoprotein domain; Region: ETF; pfam01012 762570004425 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 762570004426 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 762570004427 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 762570004428 putative oxidoreductase FixC; Provisional; Region: PRK10157 762570004429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762570004430 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 762570004431 acyl-coenzyme A oxidase; Region: PLN02526 762570004432 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 762570004433 FAD binding site [chemical binding]; other site 762570004434 substrate binding pocket [chemical binding]; other site 762570004435 catalytic base [active] 762570004436 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 762570004437 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 762570004438 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762570004439 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 762570004440 lipoyl-biotinyl attachment site [posttranslational modification]; other site 762570004441 HlyD family secretion protein; Region: HlyD_3; pfam13437 762570004442 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762570004443 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 762570004444 FtsX-like permease family; Region: FtsX; pfam02687 762570004445 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762570004446 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 762570004447 FtsX-like permease family; Region: FtsX; pfam02687 762570004448 glutamine synthetase, type I; Region: GlnA; TIGR00653 762570004449 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 762570004450 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 762570004451 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 762570004452 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762570004453 PYR/PP interface [polypeptide binding]; other site 762570004454 dimer interface [polypeptide binding]; other site 762570004455 TPP binding site [chemical binding]; other site 762570004456 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762570004457 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 762570004458 TPP-binding site [chemical binding]; other site 762570004459 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 762570004460 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 762570004461 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762570004462 minor groove reading motif; other site 762570004463 helix-hairpin-helix signature motif; other site 762570004464 substrate binding pocket [chemical binding]; other site 762570004465 active site 762570004466 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 762570004467 hypothetical protein; Reviewed; Region: PRK12497 762570004468 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 762570004469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762570004470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570004471 dimer interface [polypeptide binding]; other site 762570004472 phosphorylation site [posttranslational modification] 762570004473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570004474 ATP binding site [chemical binding]; other site 762570004475 Mg2+ binding site [ion binding]; other site 762570004476 G-X-G motif; other site 762570004477 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 762570004478 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 762570004479 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 762570004480 GDP-binding site [chemical binding]; other site 762570004481 ACT binding site; other site 762570004482 IMP binding site; other site 762570004483 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 762570004484 anti sigma factor interaction site; other site 762570004485 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 762570004486 regulatory phosphorylation site [posttranslational modification]; other site 762570004487 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 762570004488 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 762570004489 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 762570004490 putative dimer interface [polypeptide binding]; other site 762570004491 putative anticodon binding site; other site 762570004492 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762570004493 motif 1; other site 762570004494 dimer interface [polypeptide binding]; other site 762570004495 active site 762570004496 motif 2; other site 762570004497 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762570004498 active site 762570004499 motif 3; other site 762570004500 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 762570004501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762570004502 NAD(P) binding site [chemical binding]; other site 762570004503 active site 762570004504 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 762570004505 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 762570004506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 762570004507 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762570004508 TAP-like protein; Region: Abhydrolase_4; pfam08386 762570004509 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 762570004510 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 762570004511 phosphate binding site [ion binding]; other site 762570004512 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 762570004513 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570004514 active site 762570004515 NTP binding site [chemical binding]; other site 762570004516 metal binding triad [ion binding]; metal-binding site 762570004517 antibiotic binding site [chemical binding]; other site 762570004518 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762570004519 CoenzymeA binding site [chemical binding]; other site 762570004520 subunit interaction site [polypeptide binding]; other site 762570004521 PHB binding site; other site 762570004522 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 762570004523 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762570004524 substrate binding site [chemical binding]; other site 762570004525 oxyanion hole (OAH) forming residues; other site 762570004526 trimer interface [polypeptide binding]; other site 762570004527 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762570004528 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762570004529 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 762570004530 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762570004531 dimer interface [polypeptide binding]; other site 762570004532 active site 762570004533 Mgc45594 gene product and other MDR family members; Region: Mgc45594_like; cd08250 762570004534 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 762570004535 NADP binding site [chemical binding]; other site 762570004536 dimer interface [polypeptide binding]; other site 762570004537 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 762570004538 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762570004539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762570004540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762570004541 WHG domain; Region: WHG; pfam13305 762570004542 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 762570004543 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 762570004544 ligand binding site [chemical binding]; other site 762570004545 NAD binding site [chemical binding]; other site 762570004546 tetramer interface [polypeptide binding]; other site 762570004547 catalytic site [active] 762570004548 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 762570004549 triosephosphate isomerase; Provisional; Region: PRK14567 762570004550 substrate binding site [chemical binding]; other site 762570004551 dimer interface [polypeptide binding]; other site 762570004552 catalytic triad [active] 762570004553 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762570004554 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762570004555 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 762570004556 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 762570004557 GatB domain; Region: GatB_Yqey; smart00845 762570004558 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 762570004559 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 762570004560 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 762570004561 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 762570004562 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 762570004563 starch binding outer membrane protein SusD; Region: SusD; cd08977 762570004564 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 762570004565 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570004566 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 762570004567 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 762570004568 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570004569 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 762570004570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570004571 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 762570004572 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 762570004573 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 762570004574 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762570004575 catalytic triad [active] 762570004576 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 762570004577 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762570004578 tetramer interface [polypeptide binding]; other site 762570004579 TPP-binding site [chemical binding]; other site 762570004580 heterodimer interface [polypeptide binding]; other site 762570004581 phosphorylation loop region [posttranslational modification] 762570004582 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762570004583 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762570004584 alpha subunit interface [polypeptide binding]; other site 762570004585 TPP binding site [chemical binding]; other site 762570004586 heterodimer interface [polypeptide binding]; other site 762570004587 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762570004588 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 762570004589 Bacterial sugar transferase; Region: Bac_transf; pfam02397 762570004590 Radical SAM superfamily; Region: Radical_SAM; pfam04055 762570004591 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762570004592 FeS/SAM binding site; other site 762570004593 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 762570004594 putative active site [active] 762570004595 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 762570004596 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 762570004597 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 762570004598 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 762570004599 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 762570004600 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 762570004601 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 762570004602 putative RNA binding site [nucleotide binding]; other site 762570004603 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 762570004604 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 762570004605 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 762570004606 Na binding site [ion binding]; other site 762570004607 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 762570004608 acetyl-CoA synthetase; Provisional; Region: PRK00174 762570004609 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 762570004610 active site 762570004611 CoA binding site [chemical binding]; other site 762570004612 acyl-activating enzyme (AAE) consensus motif; other site 762570004613 AMP binding site [chemical binding]; other site 762570004614 acetate binding site [chemical binding]; other site 762570004615 PAS domain; Region: PAS; smart00091 762570004616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762570004617 Response regulator receiver domain; Region: Response_reg; pfam00072 762570004618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570004619 active site 762570004620 phosphorylation site [posttranslational modification] 762570004621 intermolecular recognition site; other site 762570004622 dimerization interface [polypeptide binding]; other site 762570004623 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 762570004624 Na binding site [ion binding]; other site 762570004625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570004626 dimer interface [polypeptide binding]; other site 762570004627 phosphorylation site [posttranslational modification] 762570004628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570004629 ATP binding site [chemical binding]; other site 762570004630 G-X-G motif; other site 762570004631 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762570004632 putative DNA binding site [nucleotide binding]; other site 762570004633 putative Zn2+ binding site [ion binding]; other site 762570004634 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 762570004635 PAS fold; Region: PAS; pfam00989 762570004636 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 762570004637 active site 762570004638 catalytic site [active] 762570004639 substrate binding site [chemical binding]; other site 762570004640 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 762570004641 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762570004642 P-loop; other site 762570004643 Magnesium ion binding site [ion binding]; other site 762570004644 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762570004645 Magnesium ion binding site [ion binding]; other site 762570004646 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 762570004647 putative active site [active] 762570004648 catalytic triad [active] 762570004649 putative dimer interface [polypeptide binding]; other site 762570004650 Maf-like protein; Region: Maf; pfam02545 762570004651 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 762570004652 active site 762570004653 dimer interface [polypeptide binding]; other site 762570004654 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 762570004655 catalytic triad [active] 762570004656 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 762570004657 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 762570004658 putative active site; other site 762570004659 catalytic triad [active] 762570004660 putative dimer interface [polypeptide binding]; other site 762570004661 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 762570004662 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 762570004663 HDOD domain; Region: HDOD; pfam08668 762570004664 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 762570004665 homooctamer interface [polypeptide binding]; other site 762570004666 active site 762570004667 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 762570004668 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 762570004669 substrate binding site [chemical binding]; other site 762570004670 ATP binding site [chemical binding]; other site 762570004671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570004672 binding surface 762570004673 TPR motif; other site 762570004674 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 762570004675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570004676 binding surface 762570004677 TPR motif; other site 762570004678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 762570004679 binding surface 762570004680 TPR motif; other site 762570004681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570004682 binding surface 762570004683 TPR motif; other site 762570004684 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 762570004685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570004686 binding surface 762570004687 TPR motif; other site 762570004688 Tetratricopeptide repeat; Region: TPR_12; pfam13424 762570004689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570004690 binding surface 762570004691 TPR repeat; Region: TPR_11; pfam13414 762570004692 TPR motif; other site 762570004693 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 762570004694 Tetratricopeptide repeat; Region: TPR_12; pfam13424 762570004695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570004696 binding surface 762570004697 TPR motif; other site 762570004698 Tetratricopeptide repeat; Region: TPR_12; pfam13424 762570004699 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570004700 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 762570004701 IHF dimer interface [polypeptide binding]; other site 762570004702 IHF - DNA interface [nucleotide binding]; other site 762570004703 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 762570004704 IHF dimer interface [polypeptide binding]; other site 762570004705 Sporulation related domain; Region: SPOR; pfam05036 762570004706 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 762570004707 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 762570004708 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 762570004709 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 762570004710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570004711 Walker A motif; other site 762570004712 ATP binding site [chemical binding]; other site 762570004713 Walker B motif; other site 762570004714 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 762570004715 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 762570004716 ATP-NAD kinase; Region: NAD_kinase; pfam01513 762570004717 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762570004718 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762570004719 DNA binding site [nucleotide binding] 762570004720 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762570004721 dimerization interface [polypeptide binding]; other site 762570004722 ligand binding site [chemical binding]; other site 762570004723 D-mannonate oxidoreductase; Provisional; Region: PRK08277 762570004724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762570004725 NAD(P) binding site [chemical binding]; other site 762570004726 active site 762570004727 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 762570004728 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 762570004729 active site 762570004730 DNA binding site [nucleotide binding] 762570004731 Tetratricopeptide repeat; Region: TPR_12; pfam13424 762570004732 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570004733 binding surface 762570004734 TPR motif; other site 762570004735 putative acyltransferase; Provisional; Region: PRK05790 762570004736 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762570004737 dimer interface [polypeptide binding]; other site 762570004738 active site 762570004739 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 762570004740 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 762570004741 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570004742 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 762570004743 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762570004744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762570004745 motif II; other site 762570004746 SnoaL-like domain; Region: SnoaL_3; pfam13474 762570004747 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 762570004748 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762570004749 molybdopterin cofactor binding site; other site 762570004750 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 762570004751 molybdopterin cofactor binding site; other site 762570004752 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 762570004753 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 762570004754 DNA-binding site [nucleotide binding]; DNA binding site 762570004755 RNA-binding motif; other site 762570004756 Protein of unknown function DUF72; Region: DUF72; pfam01904 762570004757 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 762570004758 putative active site [active] 762570004759 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 762570004760 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 762570004761 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 762570004762 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762570004763 catalytic core [active] 762570004764 NRDE protein; Region: NRDE; pfam05742 762570004765 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570004766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762570004767 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 762570004768 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 762570004769 active site 762570004770 dimer interface [polypeptide binding]; other site 762570004771 metal binding site [ion binding]; metal-binding site 762570004772 Family of unknown function (DUF490); Region: DUF490; pfam04357 762570004773 ribonuclease R; Region: RNase_R; TIGR02063 762570004774 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 762570004775 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762570004776 RNB domain; Region: RNB; pfam00773 762570004777 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 762570004778 RNA binding site [nucleotide binding]; other site 762570004779 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 762570004780 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762570004781 inhibitor-cofactor binding pocket; inhibition site 762570004782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570004783 catalytic residue [active] 762570004784 Ferrochelatase; Region: Ferrochelatase; pfam00762 762570004785 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 762570004786 C-terminal domain interface [polypeptide binding]; other site 762570004787 active site 762570004788 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 762570004789 active site 762570004790 N-terminal domain interface [polypeptide binding]; other site 762570004791 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 762570004792 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 762570004793 active site 762570004794 substrate-binding site [chemical binding]; other site 762570004795 metal-binding site [ion binding] 762570004796 ATP binding site [chemical binding]; other site 762570004797 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 762570004798 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762570004799 active site 762570004800 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 762570004801 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 762570004802 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 762570004803 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 762570004804 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 762570004805 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 762570004806 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 762570004807 active site 762570004808 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 762570004809 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 762570004810 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 762570004811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570004812 dimer interface [polypeptide binding]; other site 762570004813 phosphorylation site [posttranslational modification] 762570004814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570004815 ATP binding site [chemical binding]; other site 762570004816 Mg2+ binding site [ion binding]; other site 762570004817 G-X-G motif; other site 762570004818 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 762570004819 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 762570004820 substrate binding site [chemical binding]; other site 762570004821 active site 762570004822 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 762570004823 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 762570004824 beta-D-glucuronidase; Provisional; Region: PRK10150 762570004825 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 762570004826 PGAP1-like protein; Region: PGAP1; pfam07819 762570004827 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 762570004828 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570004829 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762570004830 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 762570004831 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 762570004832 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 762570004833 active site 762570004834 nucleophile elbow; other site 762570004835 DNA protecting protein DprA; Region: dprA; TIGR00732 762570004836 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 762570004837 Peptidase S46; Region: Peptidase_S46; pfam10459 762570004838 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 762570004839 Peptidase S46; Region: Peptidase_S46; pfam10459 762570004840 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 762570004841 methionine gamma-lyase; Validated; Region: PRK07049 762570004842 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762570004843 homodimer interface [polypeptide binding]; other site 762570004844 substrate-cofactor binding pocket; other site 762570004845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570004846 catalytic residue [active] 762570004847 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 762570004848 Response regulator receiver domain; Region: Response_reg; pfam00072 762570004849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570004850 active site 762570004851 phosphorylation site [posttranslational modification] 762570004852 intermolecular recognition site; other site 762570004853 dimerization interface [polypeptide binding]; other site 762570004854 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 762570004855 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 762570004856 Cu(I) binding site [ion binding]; other site 762570004857 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 762570004858 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570004859 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 762570004860 putative catalytic site [active] 762570004861 putative metal binding site [ion binding]; other site 762570004862 putative phosphate binding site [ion binding]; other site 762570004863 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 762570004864 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 762570004865 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 762570004866 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 762570004867 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 762570004868 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762570004869 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762570004870 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762570004871 active site 762570004872 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 762570004873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 762570004874 Probable transposase; Region: OrfB_IS605; pfam01385 762570004875 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 762570004876 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570004877 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570004878 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570004879 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762570004880 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570004881 active site 762570004882 NTP binding site [chemical binding]; other site 762570004883 metal binding triad [ion binding]; metal-binding site 762570004884 antibiotic binding site [chemical binding]; other site 762570004885 AAA domain; Region: AAA_21; pfam13304 762570004886 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762570004887 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570004888 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762570004889 active site 762570004890 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762570004891 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762570004892 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570004893 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762570004894 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570004895 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570004896 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762570004897 Exostosin family; Region: Exostosin; pfam03016 762570004898 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762570004899 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570004900 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570004901 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762570004902 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570004903 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 762570004904 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 762570004905 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 762570004906 NAD binding site [chemical binding]; other site 762570004907 homotetramer interface [polypeptide binding]; other site 762570004908 homodimer interface [polypeptide binding]; other site 762570004909 active site 762570004910 substrate binding site [chemical binding]; other site 762570004911 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762570004912 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 762570004913 active site 762570004914 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 762570004915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762570004916 NAD(P) binding site [chemical binding]; other site 762570004917 active site 762570004918 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 762570004919 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570004920 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 762570004921 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 762570004922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762570004923 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 762570004924 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570004925 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762570004926 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 762570004927 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 762570004928 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 762570004929 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 762570004930 Protein of unknown function (DUF563); Region: DUF563; pfam04577 762570004931 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 762570004932 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762570004933 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762570004934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762570004935 Walker A/P-loop; other site 762570004936 ATP binding site [chemical binding]; other site 762570004937 Q-loop/lid; other site 762570004938 ABC transporter signature motif; other site 762570004939 Walker B; other site 762570004940 D-loop; other site 762570004941 H-loop/switch region; other site 762570004942 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 762570004943 Chain length determinant protein; Region: Wzz; pfam02706 762570004944 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 762570004945 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 762570004946 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 762570004947 Bacterial sugar transferase; Region: Bac_transf; pfam02397 762570004948 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 762570004949 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570004950 putative ADP-binding pocket [chemical binding]; other site 762570004951 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762570004952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570004953 active site 762570004954 phosphorylation site [posttranslational modification] 762570004955 intermolecular recognition site; other site 762570004956 dimerization interface [polypeptide binding]; other site 762570004957 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762570004958 DNA binding residues [nucleotide binding] 762570004959 dimerization interface [polypeptide binding]; other site 762570004960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762570004961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570004962 active site 762570004963 phosphorylation site [posttranslational modification] 762570004964 intermolecular recognition site; other site 762570004965 dimerization interface [polypeptide binding]; other site 762570004966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762570004967 DNA binding residues [nucleotide binding] 762570004968 dimerization interface [polypeptide binding]; other site 762570004969 PAS fold; Region: PAS; pfam00989 762570004970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570004971 putative active site [active] 762570004972 heme pocket [chemical binding]; other site 762570004973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 762570004974 Histidine kinase; Region: HisKA_3; pfam07730 762570004975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570004976 ATP binding site [chemical binding]; other site 762570004977 Mg2+ binding site [ion binding]; other site 762570004978 G-X-G motif; other site 762570004979 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 762570004980 NlpC/P60 family; Region: NLPC_P60; pfam00877 762570004981 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 762570004982 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 762570004983 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 762570004984 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 762570004985 Transglycosylase; Region: Transgly; cl17702 762570004986 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 762570004987 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 762570004988 tetramer interface [polypeptide binding]; other site 762570004989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570004990 catalytic residue [active] 762570004991 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 762570004992 active site 762570004993 Zn binding site [ion binding]; other site 762570004994 Colicin V production protein; Region: Colicin_V; pfam02674 762570004995 Yqey-like protein; Region: YqeY; pfam09424 762570004996 PQQ-like domain; Region: PQQ_2; pfam13360 762570004997 PQQ-like domain; Region: PQQ_2; pfam13360 762570004998 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 762570004999 Trp docking motif [polypeptide binding]; other site 762570005000 active site 762570005001 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 762570005002 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570005003 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570005004 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570005005 Surface antigen; Region: Bac_surface_Ag; pfam01103 762570005006 Suppression of tumorigenicity 7; Region: ST7; cd11557 762570005007 Trehalose utilisation; Region: ThuA; pfam06283 762570005008 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 762570005009 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 762570005010 Metal-binding active site; metal-binding site 762570005011 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 762570005012 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 762570005013 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 762570005014 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 762570005015 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 762570005016 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 762570005017 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 762570005018 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762570005019 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 762570005020 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 762570005021 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 762570005022 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 762570005023 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 762570005024 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 762570005025 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 762570005026 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 762570005027 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 762570005028 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 762570005029 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 762570005030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 762570005031 TPR repeat; Region: TPR_11; pfam13414 762570005032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570005033 binding surface 762570005034 TPR motif; other site 762570005035 TPR repeat; Region: TPR_11; pfam13414 762570005036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570005037 binding surface 762570005038 TPR motif; other site 762570005039 TPR repeat; Region: TPR_11; pfam13414 762570005040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570005041 TPR repeat; Region: TPR_11; pfam13414 762570005042 TPR motif; other site 762570005043 binding surface 762570005044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570005045 TPR motif; other site 762570005046 binding surface 762570005047 TPR repeat; Region: TPR_11; pfam13414 762570005048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570005049 binding surface 762570005050 TPR motif; other site 762570005051 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570005052 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 762570005053 Protein of unknown function, DUF608; Region: DUF608; pfam04685 762570005054 Uncharacterized conserved protein [Function unknown]; Region: COG2361 762570005055 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570005056 active site 762570005057 NTP binding site [chemical binding]; other site 762570005058 metal binding triad [ion binding]; metal-binding site 762570005059 antibiotic binding site [chemical binding]; other site 762570005060 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 762570005061 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 762570005062 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 762570005063 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 762570005064 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 762570005065 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 762570005066 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762570005067 Walker A/P-loop; other site 762570005068 ATP binding site [chemical binding]; other site 762570005069 Q-loop/lid; other site 762570005070 ABC transporter signature motif; other site 762570005071 Walker B; other site 762570005072 D-loop; other site 762570005073 H-loop/switch region; other site 762570005074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 762570005075 Protein of unknown function (DUF433); Region: DUF433; pfam04255 762570005076 alpha-glucosidase; Provisional; Region: PRK10137 762570005077 Trehalase; Region: Trehalase; cl17346 762570005078 Nudix hydrolase homolog; Region: PLN02791 762570005079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762570005080 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762570005081 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 762570005082 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762570005083 HlyD family secretion protein; Region: HlyD_3; pfam13437 762570005084 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762570005085 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762570005086 Walker A/P-loop; other site 762570005087 ATP binding site [chemical binding]; other site 762570005088 Q-loop/lid; other site 762570005089 ABC transporter signature motif; other site 762570005090 Walker B; other site 762570005091 D-loop; other site 762570005092 H-loop/switch region; other site 762570005093 Outer membrane efflux protein; Region: OEP; pfam02321 762570005094 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762570005095 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762570005096 Walker A/P-loop; other site 762570005097 ATP binding site [chemical binding]; other site 762570005098 Q-loop/lid; other site 762570005099 ABC transporter signature motif; other site 762570005100 Walker B; other site 762570005101 D-loop; other site 762570005102 H-loop/switch region; other site 762570005103 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 762570005104 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 762570005105 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 762570005106 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 762570005107 tellurium resistance terB-like protein; Region: terB_like; cl11965 762570005108 metal binding site [ion binding]; metal-binding site 762570005109 tellurium resistance terB-like protein; Region: terB_like; cd07177 762570005110 metal binding site [ion binding]; metal-binding site 762570005111 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762570005112 CoA binding domain; Region: CoA_binding_2; pfam13380 762570005113 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 762570005114 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 762570005115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762570005116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762570005117 Coenzyme A binding pocket [chemical binding]; other site 762570005118 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 762570005119 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 762570005120 active site 762570005121 substrate binding site [chemical binding]; other site 762570005122 metal binding site [ion binding]; metal-binding site 762570005123 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 762570005124 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 762570005125 protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473 762570005126 UbiA prenyltransferase family; Region: UbiA; pfam01040 762570005127 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762570005128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762570005129 Walker A/P-loop; other site 762570005130 ATP binding site [chemical binding]; other site 762570005131 Q-loop/lid; other site 762570005132 ABC transporter signature motif; other site 762570005133 Walker B; other site 762570005134 D-loop; other site 762570005135 H-loop/switch region; other site 762570005136 ABC-2 type transporter; Region: ABC2_membrane; cl17235 762570005137 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 762570005138 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 762570005139 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762570005140 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762570005141 active site 762570005142 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762570005143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570005144 phosphorylation site [posttranslational modification] 762570005145 dimer interface [polypeptide binding]; other site 762570005146 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762570005147 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 762570005148 quinolinate synthetase; Provisional; Region: PRK09375 762570005149 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762570005150 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762570005151 Walker A/P-loop; other site 762570005152 ATP binding site [chemical binding]; other site 762570005153 Q-loop/lid; other site 762570005154 ABC transporter signature motif; other site 762570005155 Walker B; other site 762570005156 D-loop; other site 762570005157 H-loop/switch region; other site 762570005158 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 762570005159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570005160 active site 762570005161 phosphorylation site [posttranslational modification] 762570005162 intermolecular recognition site; other site 762570005163 dimerization interface [polypeptide binding]; other site 762570005164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570005165 Walker A motif; other site 762570005166 ATP binding site [chemical binding]; other site 762570005167 Walker B motif; other site 762570005168 arginine finger; other site 762570005169 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762570005170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 762570005171 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 762570005172 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 762570005173 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 762570005174 Phosphoglycerate kinase; Region: PGK; pfam00162 762570005175 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 762570005176 substrate binding site [chemical binding]; other site 762570005177 hinge regions; other site 762570005178 ADP binding site [chemical binding]; other site 762570005179 catalytic site [active] 762570005180 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 762570005181 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762570005182 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 762570005183 Amidinotransferase; Region: Amidinotransf; pfam02274 762570005184 prephenate dehydrogenase; Validated; Region: PRK06545 762570005185 prephenate dehydrogenase; Validated; Region: PRK08507 762570005186 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 762570005187 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 762570005188 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 762570005189 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 762570005190 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 762570005191 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 762570005192 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 762570005193 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 762570005194 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 762570005195 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 762570005196 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 762570005197 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 762570005198 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 762570005199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570005200 S-adenosylmethionine binding site [chemical binding]; other site 762570005201 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 762570005202 classical (c) SDRs; Region: SDR_c; cd05233 762570005203 NAD(P) binding site [chemical binding]; other site 762570005204 active site 762570005205 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl17183 762570005206 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762570005207 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 762570005208 High potential iron-sulfur protein; Region: HIPIP; pfam01355 762570005209 Acylphosphatase; Region: Acylphosphatase; pfam00708 762570005210 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 762570005211 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 762570005212 active site 762570005213 catalytic site [active] 762570005214 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 762570005215 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 762570005216 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 762570005217 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762570005218 putative catalytic residue [active] 762570005219 Peptidase family M48; Region: Peptidase_M48; cl12018 762570005220 Tetratricopeptide repeat; Region: TPR_12; pfam13424 762570005221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570005222 binding surface 762570005223 TPR motif; other site 762570005224 Repair protein; Region: Repair_PSII; pfam04536 762570005225 LemA family; Region: LemA; cl00742 762570005226 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 762570005227 C-terminal peptidase (prc); Region: prc; TIGR00225 762570005228 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 762570005229 protein binding site [polypeptide binding]; other site 762570005230 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 762570005231 Catalytic dyad [active] 762570005232 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 762570005233 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 762570005234 putative dimer interface [polypeptide binding]; other site 762570005235 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 762570005236 PhoU domain; Region: PhoU; pfam01895 762570005237 PhoU domain; Region: PhoU; pfam01895 762570005238 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 762570005239 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 762570005240 Walker A/P-loop; other site 762570005241 ATP binding site [chemical binding]; other site 762570005242 Q-loop/lid; other site 762570005243 ABC transporter signature motif; other site 762570005244 Walker B; other site 762570005245 D-loop; other site 762570005246 H-loop/switch region; other site 762570005247 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 762570005248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762570005249 dimer interface [polypeptide binding]; other site 762570005250 conserved gate region; other site 762570005251 putative PBP binding loops; other site 762570005252 ABC-ATPase subunit interface; other site 762570005253 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 762570005254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762570005255 dimer interface [polypeptide binding]; other site 762570005256 conserved gate region; other site 762570005257 putative PBP binding loops; other site 762570005258 ABC-ATPase subunit interface; other site 762570005259 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762570005260 phosphate binding protein; Region: ptsS_2; TIGR02136 762570005261 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 762570005262 Zn binding site [ion binding]; other site 762570005263 Protein of unknown function (DUF461); Region: DUF461; cl01071 762570005264 FMN-binding domain; Region: FMN_bind; pfam04205 762570005265 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 762570005266 ApbE family; Region: ApbE; pfam02424 762570005267 phosphoglyceromutase; Provisional; Region: PRK05434 762570005268 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 762570005269 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 762570005270 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762570005271 minor groove reading motif; other site 762570005272 helix-hairpin-helix signature motif; other site 762570005273 substrate binding pocket [chemical binding]; other site 762570005274 active site 762570005275 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 762570005276 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 762570005277 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 762570005278 Putative zinc ribbon domain; Region: DUF164; pfam02591 762570005279 Uncharacterized conserved protein [Function unknown]; Region: COG0327 762570005280 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 762570005281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 762570005282 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 762570005283 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 762570005284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762570005285 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 762570005286 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 762570005287 oligomeric interface; other site 762570005288 putative active site [active] 762570005289 homodimer interface [polypeptide binding]; other site 762570005290 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 762570005291 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 762570005292 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 762570005293 Tetramer interface [polypeptide binding]; other site 762570005294 active site 762570005295 FMN-binding site [chemical binding]; other site 762570005296 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 762570005297 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 762570005298 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 762570005299 protein binding site [polypeptide binding]; other site 762570005300 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 762570005301 protein binding site [polypeptide binding]; other site 762570005302 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 762570005303 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 762570005304 putative acyl-acceptor binding pocket; other site 762570005305 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 762570005306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762570005307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570005308 dimer interface [polypeptide binding]; other site 762570005309 phosphorylation site [posttranslational modification] 762570005310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570005311 ATP binding site [chemical binding]; other site 762570005312 Mg2+ binding site [ion binding]; other site 762570005313 G-X-G motif; other site 762570005314 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 762570005315 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570005316 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 762570005317 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762570005318 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 762570005319 ATP-sulfurylase; Region: ATPS; cd00517 762570005320 active site 762570005321 HXXH motif; other site 762570005322 flexible loop; other site 762570005323 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 762570005324 ligand-binding site [chemical binding]; other site 762570005325 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 762570005326 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 762570005327 TrkA-C domain; Region: TrkA_C; pfam02080 762570005328 TrkA-C domain; Region: TrkA_C; pfam02080 762570005329 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 762570005330 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 762570005331 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 762570005332 NAD binding site [chemical binding]; other site 762570005333 putative substrate binding site 2 [chemical binding]; other site 762570005334 putative substrate binding site 1 [chemical binding]; other site 762570005335 active site 762570005336 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 762570005337 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 762570005338 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 762570005339 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 762570005340 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 762570005341 substrate binding site [chemical binding]; other site 762570005342 putative active site [active] 762570005343 redox center [active] 762570005344 Thioredoxin; Region: Thioredoxin_4; pfam13462 762570005345 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 762570005346 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 762570005347 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 762570005348 Cl- selectivity filter; other site 762570005349 Cl- binding residues [ion binding]; other site 762570005350 pore gating glutamate residue; other site 762570005351 dimer interface [polypeptide binding]; other site 762570005352 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 762570005353 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 762570005354 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762570005355 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 762570005356 intersubunit interface [polypeptide binding]; other site 762570005357 active site 762570005358 catalytic residue [active] 762570005359 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 762570005360 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762570005361 ATP binding site [chemical binding]; other site 762570005362 putative Mg++ binding site [ion binding]; other site 762570005363 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762570005364 nucleotide binding region [chemical binding]; other site 762570005365 ATP-binding site [chemical binding]; other site 762570005366 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 762570005367 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 762570005368 AAA domain; Region: AAA_14; pfam13173 762570005369 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 762570005370 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 762570005371 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 762570005372 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 762570005373 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 762570005374 substrate binding site [chemical binding]; other site 762570005375 active site 762570005376 catalytic residues [active] 762570005377 heterodimer interface [polypeptide binding]; other site 762570005378 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 762570005379 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 762570005380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570005381 catalytic residue [active] 762570005382 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 762570005383 active site 762570005384 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 762570005385 active site 762570005386 ribulose/triose binding site [chemical binding]; other site 762570005387 phosphate binding site [ion binding]; other site 762570005388 substrate (anthranilate) binding pocket [chemical binding]; other site 762570005389 product (indole) binding pocket [chemical binding]; other site 762570005390 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 762570005391 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 762570005392 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 762570005393 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 762570005394 Glutamine amidotransferase class-I; Region: GATase; pfam00117 762570005395 glutamine binding [chemical binding]; other site 762570005396 catalytic triad [active] 762570005397 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 762570005398 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 762570005399 active site 762570005400 HIGH motif; other site 762570005401 dimer interface [polypeptide binding]; other site 762570005402 KMSKS motif; other site 762570005403 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 762570005404 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 762570005405 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 762570005406 NHL repeat; Region: NHL; pfam01436 762570005407 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 762570005408 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570005409 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570005410 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570005411 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 762570005412 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 762570005413 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 762570005414 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762570005415 catalytic residues [active] 762570005416 hypothetical protein; Provisional; Region: PRK08262 762570005417 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 762570005418 metal binding site [ion binding]; metal-binding site 762570005419 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 762570005420 ATP-grasp domain; Region: ATP-grasp; pfam02222 762570005421 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 762570005422 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 762570005423 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 762570005424 active site 762570005425 HIGH motif; other site 762570005426 dimer interface [polypeptide binding]; other site 762570005427 KMSKS motif; other site 762570005428 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762570005429 RNA binding surface [nucleotide binding]; other site 762570005430 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 762570005431 SmpB-tmRNA interface; other site 762570005432 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 762570005433 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 762570005434 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 762570005435 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 762570005436 RimM N-terminal domain; Region: RimM; pfam01782 762570005437 ribosomal protein S16; Region: S16; TIGR00002 762570005438 signal recognition particle protein; Provisional; Region: PRK10867 762570005439 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 762570005440 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 762570005441 P loop; other site 762570005442 GTP binding site [chemical binding]; other site 762570005443 Signal peptide binding domain; Region: SRP_SPB; pfam02978 762570005444 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 762570005445 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 762570005446 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 762570005447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 762570005448 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 762570005449 Probable transposase; Region: OrfB_IS605; pfam01385 762570005450 PspC domain; Region: PspC; pfam04024 762570005451 potential frameshift: common BLAST hit: gi|268316575|ref|YP_003290294.1| multi-sensor signal transduction histidine kinase 762570005452 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762570005453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570005454 ATP binding site [chemical binding]; other site 762570005455 Mg2+ binding site [ion binding]; other site 762570005456 G-X-G motif; other site 762570005457 PAS domain S-box; Region: sensory_box; TIGR00229 762570005458 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570005459 putative active site [active] 762570005460 heme pocket [chemical binding]; other site 762570005461 PAS domain S-box; Region: sensory_box; TIGR00229 762570005462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570005463 putative active site [active] 762570005464 heme pocket [chemical binding]; other site 762570005465 PAS domain S-box; Region: sensory_box; TIGR00229 762570005466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570005467 putative active site [active] 762570005468 heme pocket [chemical binding]; other site 762570005469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570005470 PAS domain; Region: PAS_9; pfam13426 762570005471 putative active site [active] 762570005472 heme pocket [chemical binding]; other site 762570005473 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 762570005474 GAF domain; Region: GAF; cl17456 762570005475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570005476 PAS domain; Region: PAS_9; pfam13426 762570005477 putative active site [active] 762570005478 heme pocket [chemical binding]; other site 762570005479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570005480 dimer interface [polypeptide binding]; other site 762570005481 phosphorylation site [posttranslational modification] 762570005482 polyphosphate kinase; Provisional; Region: PRK05443 762570005483 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 762570005484 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 762570005485 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 762570005486 putative domain interface [polypeptide binding]; other site 762570005487 putative active site [active] 762570005488 catalytic site [active] 762570005489 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 762570005490 putative domain interface [polypeptide binding]; other site 762570005491 putative active site [active] 762570005492 catalytic site [active] 762570005493 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 762570005494 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762570005495 Ligand Binding Site [chemical binding]; other site 762570005496 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762570005497 Ligand Binding Site [chemical binding]; other site 762570005498 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 762570005499 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762570005500 Ligand Binding Site [chemical binding]; other site 762570005501 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762570005502 Ligand Binding Site [chemical binding]; other site 762570005503 4-alpha-glucanotransferase; Provisional; Region: PRK14508 762570005504 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 762570005505 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 762570005506 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 762570005507 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762570005508 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762570005509 dihydroorotase; Validated; Region: pyrC; PRK09357 762570005510 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 762570005511 active site 762570005512 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 762570005513 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762570005514 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762570005515 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 762570005516 alanine racemase; Reviewed; Region: alr; PRK00053 762570005517 active site 762570005518 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762570005519 dimer interface [polypeptide binding]; other site 762570005520 substrate binding site [chemical binding]; other site 762570005521 catalytic residues [active] 762570005522 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762570005523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570005524 active site 762570005525 phosphorylation site [posttranslational modification] 762570005526 intermolecular recognition site; other site 762570005527 dimerization interface [polypeptide binding]; other site 762570005528 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762570005529 DNA binding site [nucleotide binding] 762570005530 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 762570005531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762570005532 dimerization interface [polypeptide binding]; other site 762570005533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570005534 dimer interface [polypeptide binding]; other site 762570005535 phosphorylation site [posttranslational modification] 762570005536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570005537 ATP binding site [chemical binding]; other site 762570005538 Mg2+ binding site [ion binding]; other site 762570005539 G-X-G motif; other site 762570005540 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 762570005541 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762570005542 tetramer interface [polypeptide binding]; other site 762570005543 TPP-binding site [chemical binding]; other site 762570005544 heterodimer interface [polypeptide binding]; other site 762570005545 phosphorylation loop region [posttranslational modification] 762570005546 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762570005547 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762570005548 alpha subunit interface [polypeptide binding]; other site 762570005549 TPP binding site [chemical binding]; other site 762570005550 heterodimer interface [polypeptide binding]; other site 762570005551 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762570005552 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 762570005553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570005554 binding surface 762570005555 TPR motif; other site 762570005556 TPR repeat; Region: TPR_11; pfam13414 762570005557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570005558 binding surface 762570005559 TPR motif; other site 762570005560 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 762570005561 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 762570005562 putative dimer interface [polypeptide binding]; other site 762570005563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762570005564 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762570005565 dimerization interface [polypeptide binding]; other site 762570005566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570005567 dimer interface [polypeptide binding]; other site 762570005568 phosphorylation site [posttranslational modification] 762570005569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570005570 ATP binding site [chemical binding]; other site 762570005571 G-X-G motif; other site 762570005572 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762570005573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570005574 active site 762570005575 phosphorylation site [posttranslational modification] 762570005576 intermolecular recognition site; other site 762570005577 dimerization interface [polypeptide binding]; other site 762570005578 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762570005579 DNA binding site [nucleotide binding] 762570005580 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 762570005581 putative active site [active] 762570005582 putative CoA binding site [chemical binding]; other site 762570005583 nudix motif; other site 762570005584 metal binding site [ion binding]; metal-binding site 762570005585 Fe-S metabolism associated domain; Region: SufE; cl00951 762570005586 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 762570005587 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 762570005588 active site residue [active] 762570005589 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 762570005590 active site residue [active] 762570005591 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 762570005592 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 762570005593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762570005594 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 762570005595 active site 762570005596 motif I; other site 762570005597 motif II; other site 762570005598 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 762570005599 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 762570005600 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 762570005601 active site 762570005602 homotetramer interface [polypeptide binding]; other site 762570005603 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 762570005604 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570005605 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570005606 DNA primase; Validated; Region: dnaG; PRK05667 762570005607 CHC2 zinc finger; Region: zf-CHC2; pfam01807 762570005608 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 762570005609 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 762570005610 active site 762570005611 metal binding site [ion binding]; metal-binding site 762570005612 interdomain interaction site; other site 762570005613 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 762570005614 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 762570005615 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 762570005616 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 762570005617 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 762570005618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762570005619 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762570005620 Walker A/P-loop; other site 762570005621 ATP binding site [chemical binding]; other site 762570005622 Q-loop/lid; other site 762570005623 ABC transporter signature motif; other site 762570005624 Walker B; other site 762570005625 D-loop; other site 762570005626 H-loop/switch region; other site 762570005627 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 762570005628 active site 762570005629 dimer interface [polypeptide binding]; other site 762570005630 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 762570005631 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 762570005632 Ligand Binding Site [chemical binding]; other site 762570005633 Molecular Tunnel; other site 762570005634 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 762570005635 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 762570005636 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762570005637 active site 762570005638 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 762570005639 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 762570005640 TilS substrate C-terminal domain; Region: TilS_C; smart00977 762570005641 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 762570005642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570005643 ATP binding site [chemical binding]; other site 762570005644 Mg2+ binding site [ion binding]; other site 762570005645 G-X-G motif; other site 762570005646 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 762570005647 ATP binding site [chemical binding]; other site 762570005648 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 762570005649 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 762570005650 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 762570005651 CAAX protease self-immunity; Region: Abi; pfam02517 762570005652 Homeodomain-like domain; Region: HTH_23; pfam13384 762570005653 Winged helix-turn helix; Region: HTH_29; pfam13551 762570005654 Homeodomain-like domain; Region: HTH_32; pfam13565 762570005655 DDE superfamily endonuclease; Region: DDE_3; pfam13358 762570005656 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 762570005657 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 762570005658 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 762570005659 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 762570005660 active site 762570005661 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 762570005662 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 762570005663 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 762570005664 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 762570005665 homodimer interface [polypeptide binding]; other site 762570005666 NADP binding site [chemical binding]; other site 762570005667 substrate binding site [chemical binding]; other site 762570005668 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 762570005669 argininosuccinate synthase; Provisional; Region: PRK13820 762570005670 ANP binding site [chemical binding]; other site 762570005671 Substrate Binding Site II [chemical binding]; other site 762570005672 Substrate Binding Site I [chemical binding]; other site 762570005673 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762570005674 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 762570005675 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 762570005676 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 762570005677 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762570005678 inhibitor-cofactor binding pocket; inhibition site 762570005679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570005680 catalytic residue [active] 762570005681 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 762570005682 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 762570005683 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762570005684 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 762570005685 nucleotide binding site [chemical binding]; other site 762570005686 N-acetyl-L-glutamate binding site [chemical binding]; other site 762570005687 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 762570005688 MOFRL family; Region: MOFRL; pfam05161 762570005689 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 762570005690 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 762570005691 dimerization interface [polypeptide binding]; other site 762570005692 DPS ferroxidase diiron center [ion binding]; other site 762570005693 ion pore; other site 762570005694 pyruvate phosphate dikinase; Provisional; Region: PRK09279 762570005695 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 762570005696 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 762570005697 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 762570005698 HAS barrel domain; Region: HAS-barrel; pfam09378 762570005699 NurA domain; Region: NurA; pfam09376 762570005700 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 762570005701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762570005702 FeS/SAM binding site; other site 762570005703 HemN C-terminal domain; Region: HemN_C; pfam06969 762570005704 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570005705 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 762570005706 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 762570005707 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 762570005708 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 762570005709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762570005710 Coenzyme A binding pocket [chemical binding]; other site 762570005711 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 762570005712 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 762570005713 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 762570005714 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 762570005715 nucleotide binding site [chemical binding]; other site 762570005716 substrate binding site [chemical binding]; other site 762570005717 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 762570005718 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762570005719 homodimer interface [polypeptide binding]; other site 762570005720 substrate-cofactor binding pocket; other site 762570005721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570005722 catalytic residue [active] 762570005723 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 762570005724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762570005725 FeS/SAM binding site; other site 762570005726 HerA helicase [Replication, recombination, and repair]; Region: COG0433 762570005727 Domain of unknown function DUF87; Region: DUF87; pfam01935 762570005728 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 762570005729 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 762570005730 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 762570005731 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 762570005732 Beta-lactamase; Region: Beta-lactamase; pfam00144 762570005733 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 762570005734 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 762570005735 B12 binding site [chemical binding]; other site 762570005736 cobalt ligand [ion binding]; other site 762570005737 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762570005738 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 762570005739 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 762570005740 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762570005741 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 762570005742 substrate binding site [chemical binding]; other site 762570005743 oxyanion hole (OAH) forming residues; other site 762570005744 trimer interface [polypeptide binding]; other site 762570005745 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 762570005746 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 762570005747 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 762570005748 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 762570005749 NusB family; Region: NusB; pfam01029 762570005750 putative RNA binding site [nucleotide binding]; other site 762570005751 16S rRNA methyltransferase B; Provisional; Region: PRK14902 762570005752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570005753 S-adenosylmethionine binding site [chemical binding]; other site 762570005754 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 762570005755 [2Fe-2S] cluster binding site [ion binding]; other site 762570005756 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 762570005757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762570005758 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 762570005759 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 762570005760 NAD(P) binding site [chemical binding]; other site 762570005761 malate dehydrogenase; Reviewed; Region: PRK06223 762570005762 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 762570005763 NAD(P) binding site [chemical binding]; other site 762570005764 dimer interface [polypeptide binding]; other site 762570005765 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762570005766 substrate binding site [chemical binding]; other site 762570005767 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 762570005768 BNR repeat-like domain; Region: BNR_2; pfam13088 762570005769 BNR repeat-like domain; Region: BNR_2; pfam13088 762570005770 VPS10 domain; Region: VPS10; smart00602 762570005771 CrcB-like protein; Region: CRCB; cl09114 762570005772 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 762570005773 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 762570005774 M28 Zn-Peptidases; Region: M28_like_4; cd08015 762570005775 Peptidase family M28; Region: Peptidase_M28; pfam04389 762570005776 metal binding site [ion binding]; metal-binding site 762570005777 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 762570005778 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762570005779 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 762570005780 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 762570005781 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762570005782 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762570005783 HlyD family secretion protein; Region: HlyD_3; pfam13437 762570005784 FOG: CBS domain [General function prediction only]; Region: COG0517 762570005785 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 762570005786 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 762570005787 Peptidase family M1; Region: Peptidase_M1; pfam01433 762570005788 Zn binding site [ion binding]; other site 762570005789 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 762570005790 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 762570005791 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 762570005792 Bacterial sugar transferase; Region: Bac_transf; pfam02397 762570005793 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 762570005794 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 762570005795 NADP binding site [chemical binding]; other site 762570005796 active site 762570005797 putative substrate binding site [chemical binding]; other site 762570005798 GDP-mannose 4,6-dehydratase; Region: PLN02653 762570005799 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 762570005800 NADP-binding site; other site 762570005801 homotetramer interface [polypeptide binding]; other site 762570005802 substrate binding site [chemical binding]; other site 762570005803 homodimer interface [polypeptide binding]; other site 762570005804 active site 762570005805 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 762570005806 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 762570005807 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570005808 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762570005809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570005810 S-adenosylmethionine binding site [chemical binding]; other site 762570005811 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762570005812 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570005813 O-Antigen ligase; Region: Wzy_C; pfam04932 762570005814 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 762570005815 GDP-Fucose binding site [chemical binding]; other site 762570005816 Methyltransferase domain; Region: Methyltransf_24; pfam13578 762570005817 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 762570005818 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 762570005819 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 762570005820 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 762570005821 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 762570005822 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 762570005823 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 762570005824 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 762570005825 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 762570005826 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 762570005827 Substrate binding site; other site 762570005828 Cupin domain; Region: Cupin_2; cl17218 762570005829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762570005830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762570005831 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 762570005832 Outer membrane efflux protein; Region: OEP; pfam02321 762570005833 Outer membrane efflux protein; Region: OEP; pfam02321 762570005834 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762570005835 HlyD family secretion protein; Region: HlyD_3; pfam13437 762570005836 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 762570005837 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 762570005838 MerC mercury resistance protein; Region: MerC; pfam03203 762570005839 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 762570005840 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 762570005841 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 762570005842 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 762570005843 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762570005844 ligand binding site [chemical binding]; other site 762570005845 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570005846 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 762570005847 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762570005848 N-terminal plug; other site 762570005849 ligand-binding site [chemical binding]; other site 762570005850 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 762570005851 active site 762570005852 catalytic residues [active] 762570005853 metal binding site [ion binding]; metal-binding site 762570005854 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 762570005855 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 762570005856 IHF - DNA interface [nucleotide binding]; other site 762570005857 IHF dimer interface [polypeptide binding]; other site 762570005858 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 762570005859 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762570005860 Zn2+ binding site [ion binding]; other site 762570005861 Mg2+ binding site [ion binding]; other site 762570005862 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 762570005863 synthetase active site [active] 762570005864 NTP binding site [chemical binding]; other site 762570005865 metal binding site [ion binding]; metal-binding site 762570005866 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 762570005867 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 762570005868 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 762570005869 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 762570005870 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 762570005871 alphaNTD homodimer interface [polypeptide binding]; other site 762570005872 alphaNTD - beta interaction site [polypeptide binding]; other site 762570005873 alphaNTD - beta' interaction site [polypeptide binding]; other site 762570005874 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 762570005875 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 762570005876 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 762570005877 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762570005878 RNA binding surface [nucleotide binding]; other site 762570005879 30S ribosomal protein S11; Validated; Region: PRK05309 762570005880 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 762570005881 30S ribosomal protein S13; Region: bact_S13; TIGR03631 762570005882 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 762570005883 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 762570005884 rRNA binding site [nucleotide binding]; other site 762570005885 predicted 30S ribosome binding site; other site 762570005886 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 762570005887 active site 762570005888 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 762570005889 SecY translocase; Region: SecY; pfam00344 762570005890 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 762570005891 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 762570005892 23S rRNA binding site [nucleotide binding]; other site 762570005893 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 762570005894 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 762570005895 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 762570005896 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 762570005897 5S rRNA interface [nucleotide binding]; other site 762570005898 L27 interface [polypeptide binding]; other site 762570005899 23S rRNA interface [nucleotide binding]; other site 762570005900 L5 interface [polypeptide binding]; other site 762570005901 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 762570005902 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 762570005903 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 762570005904 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 762570005905 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 762570005906 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 762570005907 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 762570005908 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 762570005909 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 762570005910 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 762570005911 RNA binding site [nucleotide binding]; other site 762570005912 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 762570005913 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 762570005914 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 762570005915 23S rRNA interface [nucleotide binding]; other site 762570005916 putative translocon interaction site; other site 762570005917 signal recognition particle (SRP54) interaction site; other site 762570005918 L23 interface [polypeptide binding]; other site 762570005919 trigger factor interaction site; other site 762570005920 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 762570005921 23S rRNA interface [nucleotide binding]; other site 762570005922 5S rRNA interface [nucleotide binding]; other site 762570005923 putative antibiotic binding site [chemical binding]; other site 762570005924 L25 interface [polypeptide binding]; other site 762570005925 L27 interface [polypeptide binding]; other site 762570005926 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 762570005927 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 762570005928 G-X-X-G motif; other site 762570005929 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 762570005930 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 762570005931 putative translocon binding site; other site 762570005932 protein-rRNA interface [nucleotide binding]; other site 762570005933 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 762570005934 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 762570005935 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 762570005936 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 762570005937 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 762570005938 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 762570005939 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 762570005940 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 762570005941 elongation factor Tu; Reviewed; Region: PRK00049 762570005942 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 762570005943 G1 box; other site 762570005944 GEF interaction site [polypeptide binding]; other site 762570005945 GTP/Mg2+ binding site [chemical binding]; other site 762570005946 Switch I region; other site 762570005947 G2 box; other site 762570005948 G3 box; other site 762570005949 Switch II region; other site 762570005950 G4 box; other site 762570005951 G5 box; other site 762570005952 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 762570005953 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 762570005954 Antibiotic Binding Site [chemical binding]; other site 762570005955 elongation factor G; Reviewed; Region: PRK00007 762570005956 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 762570005957 G1 box; other site 762570005958 putative GEF interaction site [polypeptide binding]; other site 762570005959 GTP/Mg2+ binding site [chemical binding]; other site 762570005960 Switch I region; other site 762570005961 G2 box; other site 762570005962 G3 box; other site 762570005963 Switch II region; other site 762570005964 G4 box; other site 762570005965 G5 box; other site 762570005966 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 762570005967 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 762570005968 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 762570005969 30S ribosomal protein S7; Validated; Region: PRK05302 762570005970 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 762570005971 S17 interaction site [polypeptide binding]; other site 762570005972 S8 interaction site; other site 762570005973 16S rRNA interaction site [nucleotide binding]; other site 762570005974 streptomycin interaction site [chemical binding]; other site 762570005975 23S rRNA interaction site [nucleotide binding]; other site 762570005976 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 762570005977 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 762570005978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570005979 Walker B motif; other site 762570005980 arginine finger; other site 762570005981 Peptidase family M41; Region: Peptidase_M41; pfam01434 762570005982 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 762570005983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 762570005984 binding surface 762570005985 TPR motif; other site 762570005986 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 762570005987 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 762570005988 domain interfaces; other site 762570005989 active site 762570005990 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 762570005991 Peptidase family M50; Region: Peptidase_M50; pfam02163 762570005992 active site 762570005993 putative substrate binding region [chemical binding]; other site 762570005994 FOG: CBS domain [General function prediction only]; Region: COG0517 762570005995 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 762570005996 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570005997 Domain of unknown function DUF21; Region: DUF21; pfam01595 762570005998 Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Region: COG3620 762570005999 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762570006000 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 762570006001 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762570006002 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762570006003 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762570006004 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 762570006005 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 762570006006 intersubunit interface [polypeptide binding]; other site 762570006007 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 762570006008 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 762570006009 active site 762570006010 dimer interface [polypeptide binding]; other site 762570006011 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570006012 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762570006013 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 762570006014 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 762570006015 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 762570006016 Isochorismatase family; Region: Isochorismatase; pfam00857 762570006017 catalytic triad [active] 762570006018 metal binding site [ion binding]; metal-binding site 762570006019 conserved cis-peptide bond; other site 762570006020 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 762570006021 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 762570006022 NAD(P) binding site [chemical binding]; other site 762570006023 catalytic residues [active] 762570006024 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 762570006025 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 762570006026 oligomer interface [polypeptide binding]; other site 762570006027 active site 762570006028 metal binding site [ion binding]; metal-binding site 762570006029 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762570006030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570006031 active site 762570006032 phosphorylation site [posttranslational modification] 762570006033 intermolecular recognition site; other site 762570006034 dimerization interface [polypeptide binding]; other site 762570006035 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762570006036 DNA binding site [nucleotide binding] 762570006037 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762570006038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570006039 active site 762570006040 phosphorylation site [posttranslational modification] 762570006041 intermolecular recognition site; other site 762570006042 dimerization interface [polypeptide binding]; other site 762570006043 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762570006044 DNA binding site [nucleotide binding] 762570006045 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 762570006046 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 762570006047 Ligand Binding Site [chemical binding]; other site 762570006048 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762570006049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762570006050 NAD(P) binding site [chemical binding]; other site 762570006051 active site 762570006052 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762570006053 homotrimer interaction site [polypeptide binding]; other site 762570006054 putative active site [active] 762570006055 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762570006056 active site 762570006057 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 762570006058 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 762570006059 active site 762570006060 metal binding site [ion binding]; metal-binding site 762570006061 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 762570006062 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 762570006063 Haemolytic domain; Region: Haemolytic; pfam01809 762570006064 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 762570006065 MPT binding site; other site 762570006066 trimer interface [polypeptide binding]; other site 762570006067 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 762570006068 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 762570006069 active site 762570006070 HIGH motif; other site 762570006071 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 762570006072 KMSKS motif; other site 762570006073 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762570006074 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 762570006075 dimer interface [polypeptide binding]; other site 762570006076 allosteric magnesium binding site [ion binding]; other site 762570006077 active site 762570006078 aspartate-rich active site metal binding site; other site 762570006079 Schiff base residues; other site 762570006080 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 762570006081 flagellin; Provisional; Region: PRK12802 762570006082 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 762570006083 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 762570006084 Flagellar protein FliS; Region: FliS; cl00654 762570006085 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 762570006086 flagellar capping protein; Validated; Region: fliD; PRK07737 762570006087 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 762570006088 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 762570006089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570006090 active site 762570006091 phosphorylation site [posttranslational modification] 762570006092 intermolecular recognition site; other site 762570006093 dimerization interface [polypeptide binding]; other site 762570006094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570006095 Walker A motif; other site 762570006096 ATP binding site [chemical binding]; other site 762570006097 Walker B motif; other site 762570006098 arginine finger; other site 762570006099 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762570006100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762570006101 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 762570006102 dimer interface [polypeptide binding]; other site 762570006103 phosphorylation site [posttranslational modification] 762570006104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570006105 ATP binding site [chemical binding]; other site 762570006106 Mg2+ binding site [ion binding]; other site 762570006107 G-X-G motif; other site 762570006108 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 762570006109 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 762570006110 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 762570006111 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 762570006112 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 762570006113 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 762570006114 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 762570006115 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 762570006116 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 762570006117 FliG C-terminal domain; Region: FliG_C; pfam01706 762570006118 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 762570006119 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762570006120 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 762570006121 Walker A motif/ATP binding site; other site 762570006122 Walker B motif; other site 762570006123 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 762570006124 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 762570006125 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 762570006126 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 762570006127 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 762570006128 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 762570006129 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 762570006130 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 762570006131 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 762570006132 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 762570006133 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 762570006134 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 762570006135 putative CheA interaction surface; other site 762570006136 HEAT repeats; Region: HEAT_2; pfam13646 762570006137 HEAT repeats; Region: HEAT_2; pfam13646 762570006138 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 762570006139 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 762570006140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570006141 S-adenosylmethionine binding site [chemical binding]; other site 762570006142 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 762570006143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570006144 active site 762570006145 phosphorylation site [posttranslational modification] 762570006146 intermolecular recognition site; other site 762570006147 dimerization interface [polypeptide binding]; other site 762570006148 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 762570006149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570006150 active site 762570006151 phosphorylation site [posttranslational modification] 762570006152 intermolecular recognition site; other site 762570006153 dimerization interface [polypeptide binding]; other site 762570006154 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 762570006155 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 762570006156 putative binding surface; other site 762570006157 active site 762570006158 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 762570006159 putative binding surface; other site 762570006160 active site 762570006161 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 762570006162 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 762570006163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570006164 ATP binding site [chemical binding]; other site 762570006165 Mg2+ binding site [ion binding]; other site 762570006166 G-X-G motif; other site 762570006167 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 762570006168 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 762570006169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570006170 active site 762570006171 phosphorylation site [posttranslational modification] 762570006172 intermolecular recognition site; other site 762570006173 dimerization interface [polypeptide binding]; other site 762570006174 CheB methylesterase; Region: CheB_methylest; pfam01339 762570006175 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 762570006176 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 762570006177 flagellar motor protein MotS; Reviewed; Region: PRK06925 762570006178 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 762570006179 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762570006180 ligand binding site [chemical binding]; other site 762570006181 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 762570006182 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 762570006183 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 762570006184 flagellar motor switch protein FliN; Region: fliN; TIGR02480 762570006185 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 762570006186 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 762570006187 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 762570006188 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 762570006189 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 762570006190 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 762570006191 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 762570006192 FHIPEP family; Region: FHIPEP; pfam00771 762570006193 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 762570006194 AAA domain; Region: AAA_17; pfam13207 762570006195 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 762570006196 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762570006197 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 762570006198 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570006199 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 762570006200 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570006201 DNA binding residues [nucleotide binding] 762570006202 SurA N-terminal domain; Region: SurA_N_3; cl07813 762570006203 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 762570006204 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 762570006205 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 762570006206 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 762570006207 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 762570006208 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 762570006209 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 762570006210 PhoH-like protein; Region: PhoH; pfam02562 762570006211 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 762570006212 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762570006213 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762570006214 KWG Leptospira; Region: KWG; pfam07656 762570006215 KWG Leptospira; Region: KWG; pfam07656 762570006216 KWG Leptospira; Region: KWG; pfam07656 762570006217 KWG Leptospira; Region: KWG; pfam07656 762570006218 KWG Leptospira; Region: KWG; pfam07656 762570006219 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 762570006220 tetramerization interface [polypeptide binding]; other site 762570006221 active site 762570006222 pantoate--beta-alanine ligase; Region: panC; TIGR00018 762570006223 Pantoate-beta-alanine ligase; Region: PanC; cd00560 762570006224 active site 762570006225 ATP-binding site [chemical binding]; other site 762570006226 pantoate-binding site; other site 762570006227 HXXH motif; other site 762570006228 fumarate hydratase; Reviewed; Region: fumC; PRK00485 762570006229 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 762570006230 active sites [active] 762570006231 tetramer interface [polypeptide binding]; other site 762570006232 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 762570006233 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 762570006234 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 762570006235 protein binding site [polypeptide binding]; other site 762570006236 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 762570006237 protein binding site [polypeptide binding]; other site 762570006238 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 762570006239 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 762570006240 dimer interface [polypeptide binding]; other site 762570006241 ssDNA binding site [nucleotide binding]; other site 762570006242 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762570006243 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 762570006244 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 762570006245 homodimer interface [polypeptide binding]; other site 762570006246 metal binding site [ion binding]; metal-binding site 762570006247 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 762570006248 homodimer interface [polypeptide binding]; other site 762570006249 active site 762570006250 putative chemical substrate binding site [chemical binding]; other site 762570006251 metal binding site [ion binding]; metal-binding site 762570006252 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 762570006253 catalytic triad [active] 762570006254 putative active site [active] 762570006255 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 762570006256 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 762570006257 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 762570006258 active site 762570006259 catalytic residues [active] 762570006260 metal binding site [ion binding]; metal-binding site 762570006261 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 762570006262 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 762570006263 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 762570006264 substrate binding site [chemical binding]; other site 762570006265 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 762570006266 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 762570006267 substrate binding site [chemical binding]; other site 762570006268 ligand binding site [chemical binding]; other site 762570006269 2-isopropylmalate synthase; Validated; Region: PRK00915 762570006270 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 762570006271 active site 762570006272 catalytic residues [active] 762570006273 metal binding site [ion binding]; metal-binding site 762570006274 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 762570006275 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 762570006276 tartrate dehydrogenase; Region: TTC; TIGR02089 762570006277 ketol-acid reductoisomerase; Provisional; Region: PRK05479 762570006278 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 762570006279 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 762570006280 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 762570006281 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 762570006282 putative valine binding site [chemical binding]; other site 762570006283 dimer interface [polypeptide binding]; other site 762570006284 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 762570006285 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 762570006286 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762570006287 PYR/PP interface [polypeptide binding]; other site 762570006288 dimer interface [polypeptide binding]; other site 762570006289 TPP binding site [chemical binding]; other site 762570006290 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762570006291 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 762570006292 TPP-binding site [chemical binding]; other site 762570006293 dimer interface [polypeptide binding]; other site 762570006294 Cation transport protein; Region: TrkH; cl17365 762570006295 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 762570006296 TrkA-N domain; Region: TrkA_N; pfam02254 762570006297 TrkA-C domain; Region: TrkA_C; pfam02080 762570006298 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762570006299 dimerization interface [polypeptide binding]; other site 762570006300 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 762570006301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570006302 dimer interface [polypeptide binding]; other site 762570006303 phosphorylation site [posttranslational modification] 762570006304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570006305 ATP binding site [chemical binding]; other site 762570006306 Mg2+ binding site [ion binding]; other site 762570006307 G-X-G motif; other site 762570006308 glyoxylate reductase; Reviewed; Region: PRK13243 762570006309 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 762570006310 dimerization interface [polypeptide binding]; other site 762570006311 ligand binding site [chemical binding]; other site 762570006312 NADP binding site [chemical binding]; other site 762570006313 catalytic site [active] 762570006314 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 762570006315 MutS domain III; Region: MutS_III; pfam05192 762570006316 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 762570006317 Walker A/P-loop; other site 762570006318 ATP binding site [chemical binding]; other site 762570006319 Q-loop/lid; other site 762570006320 ABC transporter signature motif; other site 762570006321 Walker B; other site 762570006322 D-loop; other site 762570006323 H-loop/switch region; other site 762570006324 Smr domain; Region: Smr; pfam01713 762570006325 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 762570006326 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 762570006327 active site 762570006328 Substrate binding site; other site 762570006329 Mg++ binding site; other site 762570006330 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 762570006331 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 762570006332 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762570006333 ligand binding site [chemical binding]; other site 762570006334 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 762570006335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570006336 binding surface 762570006337 TPR motif; other site 762570006338 TPR repeat; Region: TPR_11; pfam13414 762570006339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570006340 TPR motif; other site 762570006341 TPR repeat; Region: TPR_11; pfam13414 762570006342 binding surface 762570006343 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 762570006344 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 762570006345 inhibitor-cofactor binding pocket; inhibition site 762570006346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570006347 catalytic residue [active] 762570006348 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 762570006349 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 762570006350 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762570006351 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 762570006352 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 762570006353 HIGH motif; other site 762570006354 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 762570006355 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 762570006356 active site 762570006357 KMSKS motif; other site 762570006358 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 762570006359 tRNA binding surface [nucleotide binding]; other site 762570006360 anticodon binding site; other site 762570006361 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 762570006362 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 762570006363 SurA N-terminal domain; Region: SurA_N_3; cl07813 762570006364 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 762570006365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762570006366 Coenzyme A binding pocket [chemical binding]; other site 762570006367 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 762570006368 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 762570006369 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 762570006370 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762570006371 catalytic residue [active] 762570006372 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 762570006373 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 762570006374 Methyltransferase domain; Region: Methyltransf_31; pfam13847 762570006375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570006376 S-adenosylmethionine binding site [chemical binding]; other site 762570006377 LytB protein; Region: LYTB; cl00507 762570006378 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 762570006379 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 762570006380 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 762570006381 Protein of unknown function (DUF448); Region: DUF448; pfam04296 762570006382 putative RNA binding cleft [nucleotide binding]; other site 762570006383 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762570006384 Domain of unknown function DUF20; Region: UPF0118; pfam01594 762570006385 mce related protein; Region: MCE; pfam02470 762570006386 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 762570006387 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 762570006388 Walker A/P-loop; other site 762570006389 ATP binding site [chemical binding]; other site 762570006390 Q-loop/lid; other site 762570006391 ABC transporter signature motif; other site 762570006392 Walker B; other site 762570006393 D-loop; other site 762570006394 H-loop/switch region; other site 762570006395 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 762570006396 Permease; Region: Permease; pfam02405 762570006397 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 762570006398 Family of unknown function (DUF490); Region: DUF490; pfam04357 762570006399 Family of unknown function (DUF490); Region: DUF490; pfam04357 762570006400 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 762570006401 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 762570006402 Surface antigen; Region: Bac_surface_Ag; pfam01103 762570006403 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 762570006404 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 762570006405 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 762570006406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570006407 Walker A motif; other site 762570006408 ATP binding site [chemical binding]; other site 762570006409 Walker B motif; other site 762570006410 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 762570006411 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 762570006412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570006413 S-adenosylmethionine binding site [chemical binding]; other site 762570006414 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 762570006415 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 762570006416 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 762570006417 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 762570006418 substrate-cofactor binding pocket; other site 762570006419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570006420 catalytic residue [active] 762570006421 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 762570006422 Threonine dehydrogenase; Region: TDH; cd05281 762570006423 structural Zn binding site [ion binding]; other site 762570006424 catalytic Zn binding site [ion binding]; other site 762570006425 tetramer interface [polypeptide binding]; other site 762570006426 NADP binding site [chemical binding]; other site 762570006427 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 762570006428 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 762570006429 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 762570006430 4Fe-4S binding domain; Region: Fer4; pfam00037 762570006431 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 762570006432 Cysteine-rich domain; Region: CCG; pfam02754 762570006433 Cysteine-rich domain; Region: CCG; pfam02754 762570006434 short chain dehydrogenase; Validated; Region: PRK08324 762570006435 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 762570006436 active site 762570006437 Zn2+ binding site [ion binding]; other site 762570006438 intersubunit interface [polypeptide binding]; other site 762570006439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762570006440 NAD(P) binding site [chemical binding]; other site 762570006441 active site 762570006442 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 762570006443 N- and C-terminal domain interface [polypeptide binding]; other site 762570006444 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 762570006445 active site 762570006446 putative catalytic site [active] 762570006447 metal binding site [ion binding]; metal-binding site 762570006448 ATP binding site [chemical binding]; other site 762570006449 carbohydrate binding site [chemical binding]; other site 762570006450 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 762570006451 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 762570006452 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 762570006453 starch binding outer membrane protein SusD; Region: SusD; cd08977 762570006454 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 762570006455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 762570006456 DNA binding residues [nucleotide binding] 762570006457 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 762570006458 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 762570006459 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762570006460 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762570006461 N-terminal plug; other site 762570006462 ligand-binding site [chemical binding]; other site 762570006463 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762570006464 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 762570006465 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 762570006466 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 762570006467 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 762570006468 substrate binding [chemical binding]; other site 762570006469 active site 762570006470 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 762570006471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 762570006472 binding surface 762570006473 TPR motif; other site 762570006474 Tetratricopeptide repeat; Region: TPR_12; pfam13424 762570006475 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 762570006476 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 762570006477 active site 762570006478 (T/H)XGH motif; other site 762570006479 Outer membrane lipoprotein; Region: YfiO; pfam13525 762570006480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570006481 binding surface 762570006482 TPR motif; other site 762570006483 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762570006484 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 762570006485 ligand binding site [chemical binding]; other site 762570006486 GMP synthase; Reviewed; Region: guaA; PRK00074 762570006487 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 762570006488 AMP/PPi binding site [chemical binding]; other site 762570006489 candidate oxyanion hole; other site 762570006490 catalytic triad [active] 762570006491 potential glutamine specificity residues [chemical binding]; other site 762570006492 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 762570006493 ATP Binding subdomain [chemical binding]; other site 762570006494 Ligand Binding sites [chemical binding]; other site 762570006495 Dimerization subdomain; other site 762570006496 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 762570006497 lipoyl attachment site [posttranslational modification]; other site 762570006498 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 762570006499 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762570006500 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 762570006501 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 762570006502 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 762570006503 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 762570006504 carboxyltransferase (CT) interaction site; other site 762570006505 biotinylation site [posttranslational modification]; other site 762570006506 elongation factor P; Validated; Region: PRK00529 762570006507 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 762570006508 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 762570006509 RNA binding site [nucleotide binding]; other site 762570006510 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 762570006511 RNA binding site [nucleotide binding]; other site 762570006512 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 762570006513 aminoacyl-tRNA ligase; Region: PLN02563 762570006514 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 762570006515 HIGH motif; other site 762570006516 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 762570006517 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762570006518 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762570006519 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762570006520 active site 762570006521 KMSKS motif; other site 762570006522 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 762570006523 tRNA binding surface [nucleotide binding]; other site 762570006524 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762570006525 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 762570006526 HD domain; Region: HD_4; pfam13328 762570006527 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 762570006528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 762570006529 Bifunctional nuclease; Region: DNase-RNase; pfam02577 762570006530 UvrB/uvrC motif; Region: UVR; pfam02151 762570006531 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 762570006532 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762570006533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570006534 homodimer interface [polypeptide binding]; other site 762570006535 catalytic residue [active] 762570006536 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 762570006537 histidinol dehydrogenase; Region: hisD; TIGR00069 762570006538 NAD binding site [chemical binding]; other site 762570006539 dimerization interface [polypeptide binding]; other site 762570006540 product binding site; other site 762570006541 substrate binding site [chemical binding]; other site 762570006542 zinc binding site [ion binding]; other site 762570006543 catalytic residues [active] 762570006544 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 762570006545 purine nucleoside phosphorylase; Provisional; Region: PRK08202 762570006546 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 762570006547 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 762570006548 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762570006549 Domain of unknown function DUF20; Region: UPF0118; pfam01594 762570006550 RecX family; Region: RecX; cl00936 762570006551 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 762570006552 Secretin and TonB N terminus short domain; Region: STN; smart00965 762570006553 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570006554 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570006555 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762570006556 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762570006557 FecR protein; Region: FecR; pfam04773 762570006558 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 762570006559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570006560 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570006561 DNA binding residues [nucleotide binding] 762570006562 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 762570006563 active site 762570006564 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 762570006565 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926 762570006566 HEAT repeats; Region: HEAT_2; pfam13646 762570006567 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 762570006568 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 762570006569 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 762570006570 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 762570006571 Protein export membrane protein; Region: SecD_SecF; cl14618 762570006572 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 762570006573 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762570006574 HlyD family secretion protein; Region: HlyD_3; pfam13437 762570006575 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 762570006576 AAA domain; Region: AAA_23; pfam13476 762570006577 Walker A/P-loop; other site 762570006578 ATP binding site [chemical binding]; other site 762570006579 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 762570006580 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 762570006581 ABC transporter signature motif; other site 762570006582 Walker B; other site 762570006583 D-loop; other site 762570006584 H-loop/switch region; other site 762570006585 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 762570006586 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 762570006587 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 762570006588 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 762570006589 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 762570006590 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 762570006591 Na binding site [ion binding]; other site 762570006592 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 762570006593 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 762570006594 Prephenate dehydratase; Region: PDT; pfam00800 762570006595 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 762570006596 putative L-Phe binding site [chemical binding]; other site 762570006597 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 762570006598 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 762570006599 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 762570006600 active site 762570006601 HIGH motif; other site 762570006602 KMSK motif region; other site 762570006603 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762570006604 tRNA binding surface [nucleotide binding]; other site 762570006605 anticodon binding site; other site 762570006606 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 762570006607 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 762570006608 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 762570006609 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 762570006610 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 762570006611 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 762570006612 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570006613 Surface antigen; Region: Bac_surface_Ag; pfam01103 762570006614 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 762570006615 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 762570006616 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 762570006617 quinone interaction residues [chemical binding]; other site 762570006618 active site 762570006619 catalytic residues [active] 762570006620 FMN binding site [chemical binding]; other site 762570006621 substrate binding site [chemical binding]; other site 762570006622 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 762570006623 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762570006624 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 762570006625 acyl-activating enzyme (AAE) consensus motif; other site 762570006626 putative AMP binding site [chemical binding]; other site 762570006627 putative active site [active] 762570006628 putative CoA binding site [chemical binding]; other site 762570006629 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 762570006630 elongation factor G; Reviewed; Region: PRK12740 762570006631 G1 box; other site 762570006632 putative GEF interaction site [polypeptide binding]; other site 762570006633 GTP/Mg2+ binding site [chemical binding]; other site 762570006634 Switch I region; other site 762570006635 G2 box; other site 762570006636 G3 box; other site 762570006637 Switch II region; other site 762570006638 G4 box; other site 762570006639 G5 box; other site 762570006640 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 762570006641 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 762570006642 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 762570006643 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 762570006644 Glycoprotease family; Region: Peptidase_M22; pfam00814 762570006645 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 762570006646 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 762570006647 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 762570006648 cell surface protein SprA; Region: surface_SprA; TIGR04189 762570006649 Motility related/secretion protein; Region: SprA_N; pfam14349 762570006650 Motility related/secretion protein; Region: SprA_N; pfam14349 762570006651 Motility related/secretion protein; Region: SprA_N; pfam14349 762570006652 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 762570006653 Protein of unknown function (DUF423); Region: DUF423; pfam04241 762570006654 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 762570006655 UGMP family protein; Validated; Region: PRK09604 762570006656 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 762570006657 Chorismate mutase type II; Region: CM_2; smart00830 762570006658 YceG-like family; Region: YceG; pfam02618 762570006659 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 762570006660 dimerization interface [polypeptide binding]; other site 762570006661 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 762570006662 prolyl-tRNA synthetase; Provisional; Region: PRK08661 762570006663 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 762570006664 dimer interface [polypeptide binding]; other site 762570006665 motif 1; other site 762570006666 active site 762570006667 motif 2; other site 762570006668 motif 3; other site 762570006669 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 762570006670 anticodon binding site; other site 762570006671 zinc-binding site [ion binding]; other site 762570006672 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570006673 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762570006674 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570006675 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 762570006676 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 762570006677 active site 762570006678 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 762570006679 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 762570006680 substrate binding site [chemical binding]; other site 762570006681 ATP binding site [chemical binding]; other site 762570006682 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 762570006683 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 762570006684 active site 762570006685 intersubunit interface [polypeptide binding]; other site 762570006686 catalytic residue [active] 762570006687 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 762570006688 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 762570006689 metal binding site [ion binding]; metal-binding site 762570006690 substrate binding pocket [chemical binding]; other site 762570006691 DctM-like transporters; Region: DctM; pfam06808 762570006692 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 762570006693 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 762570006694 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 762570006695 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 762570006696 Uncharacterized conserved protein [Function unknown]; Region: COG3189 762570006697 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 762570006698 4Fe-4S binding domain; Region: Fer4; pfam00037 762570006699 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 762570006700 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 762570006701 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 762570006702 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 762570006703 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 762570006704 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 762570006705 Hemerythrin-like domain; Region: Hr-like; cd12108 762570006706 Fe binding site [ion binding]; other site 762570006707 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 762570006708 Predicted transcriptional regulator [Transcription]; Region: COG2345 762570006709 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 762570006710 nucleoside/Zn binding site; other site 762570006711 dimer interface [polypeptide binding]; other site 762570006712 catalytic motif [active] 762570006713 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 762570006714 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 762570006715 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 762570006716 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 762570006717 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 762570006718 putative active site [active] 762570006719 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 762570006720 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762570006721 TPR repeat; Region: TPR_11; pfam13414 762570006722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570006723 binding surface 762570006724 TPR motif; other site 762570006725 KduI/IolB family; Region: KduI; cl01508 762570006726 glucuronate isomerase; Reviewed; Region: PRK02925 762570006727 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 762570006728 Rhomboid family; Region: Rhomboid; pfam01694 762570006729 Predicted membrane protein [Function unknown]; Region: COG3174 762570006730 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 762570006731 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 762570006732 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 762570006733 putative active site [active] 762570006734 catalytic triad [active] 762570006735 Uncharacterized conserved protein [Function unknown]; Region: COG2353 762570006736 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 762570006737 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762570006738 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762570006739 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 762570006740 transcription termination factor Rho; Provisional; Region: PRK12608 762570006741 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 762570006742 RNA binding site [nucleotide binding]; other site 762570006743 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 762570006744 multimer interface [polypeptide binding]; other site 762570006745 Walker A motif; other site 762570006746 ATP binding site [chemical binding]; other site 762570006747 Walker B motif; other site 762570006748 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570006749 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 762570006750 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570006751 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570006752 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570006753 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570006754 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570006755 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 762570006756 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 762570006757 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 762570006758 protein binding site [polypeptide binding]; other site 762570006759 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 762570006760 Domain interface; other site 762570006761 Peptide binding site; other site 762570006762 Active site tetrad [active] 762570006763 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 762570006764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762570006765 motif II; other site 762570006766 NAD synthetase; Provisional; Region: PRK13981 762570006767 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 762570006768 multimer interface [polypeptide binding]; other site 762570006769 active site 762570006770 catalytic triad [active] 762570006771 protein interface 1 [polypeptide binding]; other site 762570006772 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 762570006773 homodimer interface [polypeptide binding]; other site 762570006774 NAD binding pocket [chemical binding]; other site 762570006775 ATP binding pocket [chemical binding]; other site 762570006776 Mg binding site [ion binding]; other site 762570006777 active-site loop [active] 762570006778 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 762570006779 RuvA N terminal domain; Region: RuvA_N; pfam01330 762570006780 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 762570006781 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762570006782 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762570006783 dimerization interface [polypeptide binding]; other site 762570006784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570006785 dimer interface [polypeptide binding]; other site 762570006786 phosphorylation site [posttranslational modification] 762570006787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570006788 ATP binding site [chemical binding]; other site 762570006789 Mg2+ binding site [ion binding]; other site 762570006790 G-X-G motif; other site 762570006791 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 762570006792 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 762570006793 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 762570006794 metal ion-dependent adhesion site (MIDAS); other site 762570006795 NAD-dependent deacetylase; Provisional; Region: PRK00481 762570006796 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 762570006797 NAD+ binding site [chemical binding]; other site 762570006798 substrate binding site [chemical binding]; other site 762570006799 Zn binding site [ion binding]; other site 762570006800 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 762570006801 Domain of unknown function DUF59; Region: DUF59; pfam01883 762570006802 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 762570006803 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 762570006804 Walker A motif; other site 762570006805 exopolyphosphatase; Region: exo_poly_only; TIGR03706 762570006806 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762570006807 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 762570006808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570006809 S-adenosylmethionine binding site [chemical binding]; other site 762570006810 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 762570006811 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 762570006812 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 762570006813 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 762570006814 anti sigma factor interaction site; other site 762570006815 regulatory phosphorylation site [posttranslational modification]; other site 762570006816 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 762570006817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570006818 ATP binding site [chemical binding]; other site 762570006819 Mg2+ binding site [ion binding]; other site 762570006820 G-X-G motif; other site 762570006821 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 762570006822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570006823 S-adenosylmethionine binding site [chemical binding]; other site 762570006824 6-phosphofructokinase; Provisional; Region: PRK03202 762570006825 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 762570006826 active site 762570006827 ADP/pyrophosphate binding site [chemical binding]; other site 762570006828 dimerization interface [polypeptide binding]; other site 762570006829 allosteric effector site; other site 762570006830 fructose-1,6-bisphosphate binding site; other site 762570006831 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 762570006832 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 762570006833 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 762570006834 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570006835 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570006836 DNA binding residues [nucleotide binding] 762570006837 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 762570006838 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762570006839 homodimer interface [polypeptide binding]; other site 762570006840 substrate-cofactor binding pocket; other site 762570006841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570006842 catalytic residue [active] 762570006843 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 762570006844 DNA repair protein RadA; Provisional; Region: PRK11823 762570006845 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 762570006846 Walker A motif/ATP binding site; other site 762570006847 ATP binding site [chemical binding]; other site 762570006848 Walker B motif; other site 762570006849 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 762570006850 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 762570006851 Permease; Region: Permease; pfam02405 762570006852 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 762570006853 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 762570006854 Walker A/P-loop; other site 762570006855 ATP binding site [chemical binding]; other site 762570006856 Q-loop/lid; other site 762570006857 ABC transporter signature motif; other site 762570006858 Walker B; other site 762570006859 D-loop; other site 762570006860 H-loop/switch region; other site 762570006861 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 762570006862 mce related protein; Region: MCE; pfam02470 762570006863 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 762570006864 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 762570006865 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 762570006866 AAA domain; Region: AAA_18; pfam13238 762570006867 Substrate-binding site [chemical binding]; other site 762570006868 Substrate specificity [chemical binding]; other site 762570006869 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 762570006870 trimer interface [polypeptide binding]; other site 762570006871 active site 762570006872 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 762570006873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762570006874 putative substrate translocation pore; other site 762570006875 POT family; Region: PTR2; cl17359 762570006876 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 762570006877 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 762570006878 dimer interface [polypeptide binding]; other site 762570006879 anticodon binding site; other site 762570006880 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 762570006881 homodimer interface [polypeptide binding]; other site 762570006882 motif 1; other site 762570006883 active site 762570006884 motif 2; other site 762570006885 GAD domain; Region: GAD; pfam02938 762570006886 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 762570006887 motif 3; other site 762570006888 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 762570006889 spermidine synthase; Provisional; Region: PRK00811 762570006890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570006891 S-adenosylmethionine binding site [chemical binding]; other site 762570006892 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 762570006893 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 762570006894 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 762570006895 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 762570006896 Ubiquitin-like proteins; Region: UBQ; cl00155 762570006897 charged pocket; other site 762570006898 hydrophobic patch; other site 762570006899 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 762570006900 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 762570006901 Active Sites [active] 762570006902 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 762570006903 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 762570006904 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 762570006905 Response regulator receiver domain; Region: Response_reg; pfam00072 762570006906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570006907 active site 762570006908 phosphorylation site [posttranslational modification] 762570006909 intermolecular recognition site; other site 762570006910 dimerization interface [polypeptide binding]; other site 762570006911 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762570006912 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762570006913 metal binding site [ion binding]; metal-binding site 762570006914 active site 762570006915 I-site; other site 762570006916 Response regulator receiver domain; Region: Response_reg; pfam00072 762570006917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570006918 active site 762570006919 phosphorylation site [posttranslational modification] 762570006920 intermolecular recognition site; other site 762570006921 dimerization interface [polypeptide binding]; other site 762570006922 HEAT repeats; Region: HEAT_2; pfam13646 762570006923 hypothetical protein; Provisional; Region: PRK13665 762570006924 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 762570006925 trimer interface [polypeptide binding]; other site 762570006926 dimer interface [polypeptide binding]; other site 762570006927 putative active site [active] 762570006928 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 762570006929 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 762570006930 active site 762570006931 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 762570006932 putative active site [active] 762570006933 dimerization interface [polypeptide binding]; other site 762570006934 putative tRNAtyr binding site [nucleotide binding]; other site 762570006935 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 762570006936 active site 762570006937 dimerization interface [polypeptide binding]; other site 762570006938 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 762570006939 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 762570006940 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 762570006941 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 762570006942 TPP-binding site [chemical binding]; other site 762570006943 Uncharacterized conserved protein (DUF2361); Region: DUF2361; pfam10153 762570006944 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 762570006945 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 762570006946 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 762570006947 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 762570006948 P loop; other site 762570006949 GTP binding site [chemical binding]; other site 762570006950 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 762570006951 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 762570006952 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762570006953 putative trimer interface [polypeptide binding]; other site 762570006954 putative CoA binding site [chemical binding]; other site 762570006955 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 762570006956 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 762570006957 metal ion-dependent adhesion site (MIDAS); other site 762570006958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570006959 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762570006960 Walker A motif; other site 762570006961 ATP binding site [chemical binding]; other site 762570006962 Walker B motif; other site 762570006963 arginine finger; other site 762570006964 Predicted transcriptional regulators [Transcription]; Region: COG1733 762570006965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762570006966 dimerization interface [polypeptide binding]; other site 762570006967 putative DNA binding site [nucleotide binding]; other site 762570006968 putative Zn2+ binding site [ion binding]; other site 762570006969 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 762570006970 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 762570006971 NADP binding site [chemical binding]; other site 762570006972 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 762570006973 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 762570006974 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 762570006975 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 762570006976 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 762570006977 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 762570006978 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 762570006979 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 762570006980 putative metal binding site [ion binding]; other site 762570006981 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762570006982 active site 762570006983 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 762570006984 Na binding site [ion binding]; other site 762570006985 Isochorismatase family; Region: Isochorismatase; pfam00857 762570006986 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 762570006987 catalytic triad [active] 762570006988 conserved cis-peptide bond; other site 762570006989 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 762570006990 active site 762570006991 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 762570006992 dimer interface [polypeptide binding]; other site 762570006993 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 762570006994 Ligand Binding Site [chemical binding]; other site 762570006995 Molecular Tunnel; other site 762570006996 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 762570006997 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 762570006998 putative transporter; Provisional; Region: PRK10484 762570006999 Na binding site [ion binding]; other site 762570007000 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 762570007001 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 762570007002 NADP binding site [chemical binding]; other site 762570007003 homodimer interface [polypeptide binding]; other site 762570007004 active site 762570007005 Right handed beta helix region; Region: Beta_helix; pfam13229 762570007006 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570007007 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 762570007008 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 762570007009 Pectate lyase; Region: Pec_lyase_C; cl01593 762570007010 Fn3 associated; Region: Fn3_assoc; pfam13287 762570007011 PA14 domain; Region: PA14; cl08459 762570007012 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570007013 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570007014 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570007015 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762570007016 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570007017 hypothetical protein; Validated; Region: PRK00110 762570007018 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 762570007019 active site 762570007020 putative DNA-binding cleft [nucleotide binding]; other site 762570007021 dimer interface [polypeptide binding]; other site 762570007022 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 762570007023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762570007024 Walker A/P-loop; other site 762570007025 ATP binding site [chemical binding]; other site 762570007026 Q-loop/lid; other site 762570007027 ABC transporter signature motif; other site 762570007028 Walker B; other site 762570007029 D-loop; other site 762570007030 H-loop/switch region; other site 762570007031 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 762570007032 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 762570007033 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 762570007034 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762570007035 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 762570007036 Surface antigen; Region: Bac_surface_Ag; pfam01103 762570007037 trigger factor; Region: tig; TIGR00115 762570007038 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 762570007039 Clp protease; Region: CLP_protease; pfam00574 762570007040 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 762570007041 oligomer interface [polypeptide binding]; other site 762570007042 active site residues [active] 762570007043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570007044 active site 762570007045 phosphorylation site [posttranslational modification] 762570007046 intermolecular recognition site; other site 762570007047 dimerization interface [polypeptide binding]; other site 762570007048 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570007049 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762570007050 putative active site [active] 762570007051 heme pocket [chemical binding]; other site 762570007052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570007053 dimer interface [polypeptide binding]; other site 762570007054 phosphorylation site [posttranslational modification] 762570007055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570007056 ATP binding site [chemical binding]; other site 762570007057 Mg2+ binding site [ion binding]; other site 762570007058 G-X-G motif; other site 762570007059 Response regulator receiver domain; Region: Response_reg; pfam00072 762570007060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570007061 active site 762570007062 phosphorylation site [posttranslational modification] 762570007063 intermolecular recognition site; other site 762570007064 dimerization interface [polypeptide binding]; other site 762570007065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570007066 Response regulator receiver domain; Region: Response_reg; pfam00072 762570007067 active site 762570007068 phosphorylation site [posttranslational modification] 762570007069 intermolecular recognition site; other site 762570007070 dimerization interface [polypeptide binding]; other site 762570007071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570007072 PAS domain; Region: PAS_9; pfam13426 762570007073 putative active site [active] 762570007074 heme pocket [chemical binding]; other site 762570007075 PAS fold; Region: PAS_4; pfam08448 762570007076 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 762570007077 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570007078 putative active site [active] 762570007079 heme pocket [chemical binding]; other site 762570007080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570007081 dimer interface [polypeptide binding]; other site 762570007082 phosphorylation site [posttranslational modification] 762570007083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570007084 ATP binding site [chemical binding]; other site 762570007085 Mg2+ binding site [ion binding]; other site 762570007086 G-X-G motif; other site 762570007087 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 762570007088 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762570007089 E3 interaction surface; other site 762570007090 lipoyl attachment site [posttranslational modification]; other site 762570007091 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762570007092 E3 interaction surface; other site 762570007093 lipoyl attachment site [posttranslational modification]; other site 762570007094 e3 binding domain; Region: E3_binding; pfam02817 762570007095 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 762570007096 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 762570007097 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 762570007098 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 762570007099 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 762570007100 putative active site [active] 762570007101 catalytic residue [active] 762570007102 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 762570007103 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 762570007104 5S rRNA interface [nucleotide binding]; other site 762570007105 CTC domain interface [polypeptide binding]; other site 762570007106 L16 interface [polypeptide binding]; other site 762570007107 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 762570007108 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 762570007109 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762570007110 active site 762570007111 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 762570007112 homodimer interface [polypeptide binding]; other site 762570007113 homotetramer interface [polypeptide binding]; other site 762570007114 active site pocket [active] 762570007115 cleavage site 762570007116 aspartate racemase; Region: asp_race; TIGR00035 762570007117 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762570007118 HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3 762570007119 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762570007120 active site 762570007121 motif I; other site 762570007122 motif II; other site 762570007123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762570007124 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 762570007125 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 762570007126 active site 762570007127 putative lithium-binding site [ion binding]; other site 762570007128 substrate binding site [chemical binding]; other site 762570007129 PIN domain; Region: PIN_3; pfam13470 762570007130 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 762570007131 Asp-box motif; other site 762570007132 catalytic site [active] 762570007133 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 762570007134 CcmE; Region: CcmE; cl00994 762570007135 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 762570007136 CcmB protein; Region: CcmB; cl17444 762570007137 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 762570007138 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 762570007139 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570007140 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570007141 DNA binding residues [nucleotide binding] 762570007142 Cytochrome c; Region: Cytochrom_C; pfam00034 762570007143 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 762570007144 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 762570007145 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 762570007146 G1 box; other site 762570007147 putative GEF interaction site [polypeptide binding]; other site 762570007148 GTP/Mg2+ binding site [chemical binding]; other site 762570007149 Switch I region; other site 762570007150 G2 box; other site 762570007151 G3 box; other site 762570007152 Switch II region; other site 762570007153 G4 box; other site 762570007154 G5 box; other site 762570007155 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 762570007156 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 762570007157 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 762570007158 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 762570007159 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 762570007160 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 762570007161 substrate binding pocket [chemical binding]; other site 762570007162 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 762570007163 B12 binding site [chemical binding]; other site 762570007164 cobalt ligand [ion binding]; other site 762570007165 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 762570007166 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 762570007167 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 762570007168 GAF domain; Region: GAF; pfam01590 762570007169 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 762570007170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570007171 putative active site [active] 762570007172 heme pocket [chemical binding]; other site 762570007173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570007174 dimer interface [polypeptide binding]; other site 762570007175 phosphorylation site [posttranslational modification] 762570007176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570007177 ATP binding site [chemical binding]; other site 762570007178 Mg2+ binding site [ion binding]; other site 762570007179 G-X-G motif; other site 762570007180 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 762570007181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570007182 active site 762570007183 phosphorylation site [posttranslational modification] 762570007184 intermolecular recognition site; other site 762570007185 dimerization interface [polypeptide binding]; other site 762570007186 HDOD domain; Region: HDOD; pfam08668 762570007187 Response regulator receiver domain; Region: Response_reg; pfam00072 762570007188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570007189 active site 762570007190 phosphorylation site [posttranslational modification] 762570007191 intermolecular recognition site; other site 762570007192 dimerization interface [polypeptide binding]; other site 762570007193 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762570007194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570007195 active site 762570007196 phosphorylation site [posttranslational modification] 762570007197 intermolecular recognition site; other site 762570007198 dimerization interface [polypeptide binding]; other site 762570007199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762570007200 DNA binding residues [nucleotide binding] 762570007201 dimerization interface [polypeptide binding]; other site 762570007202 PAS domain S-box; Region: sensory_box; TIGR00229 762570007203 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570007204 putative active site [active] 762570007205 heme pocket [chemical binding]; other site 762570007206 GAF domain; Region: GAF; cl17456 762570007207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 762570007208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570007209 ATP binding site [chemical binding]; other site 762570007210 Mg2+ binding site [ion binding]; other site 762570007211 G-X-G motif; other site 762570007212 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 762570007213 dimerization interface [polypeptide binding]; other site 762570007214 putative active cleft [active] 762570007215 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 762570007216 active site 762570007217 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 762570007218 Na binding site [ion binding]; other site 762570007219 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 762570007220 putative metal binding site [ion binding]; other site 762570007221 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 762570007222 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570007223 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570007224 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 762570007225 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570007226 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570007227 MarR family; Region: MarR_2; pfam12802 762570007228 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 762570007229 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762570007230 nucleotide binding site [chemical binding]; other site 762570007231 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762570007232 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 762570007233 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 762570007234 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762570007235 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 762570007236 acyl-activating enzyme (AAE) consensus motif; other site 762570007237 acyl-activating enzyme (AAE) consensus motif; other site 762570007238 putative AMP binding site [chemical binding]; other site 762570007239 putative active site [active] 762570007240 putative CoA binding site [chemical binding]; other site 762570007241 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 762570007242 Na binding site [ion binding]; other site 762570007243 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 762570007244 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 762570007245 dimer interface [polypeptide binding]; other site 762570007246 active site 762570007247 CoA binding pocket [chemical binding]; other site 762570007248 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 762570007249 homotetramer interface [polypeptide binding]; other site 762570007250 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 762570007251 NAD(P) binding site [chemical binding]; other site 762570007252 homodimer interface [polypeptide binding]; other site 762570007253 active site 762570007254 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570007255 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570007256 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762570007257 Predicted transcriptional regulators [Transcription]; Region: COG1510 762570007258 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 762570007259 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 762570007260 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 762570007261 DNA binding residues [nucleotide binding] 762570007262 dimer interface [polypeptide binding]; other site 762570007263 metal binding site [ion binding]; metal-binding site 762570007264 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762570007265 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762570007266 metal-binding site [ion binding] 762570007267 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 762570007268 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762570007269 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762570007270 motif II; other site 762570007271 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762570007272 metal-binding site [ion binding] 762570007273 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 762570007274 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762570007275 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762570007276 HlyD family secretion protein; Region: HlyD_3; pfam13437 762570007277 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 762570007278 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 762570007279 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 762570007280 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 762570007281 putative active site [active] 762570007282 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 762570007283 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 762570007284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762570007285 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762570007286 putative substrate translocation pore; other site 762570007287 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 762570007288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762570007289 dimerization interface [polypeptide binding]; other site 762570007290 putative DNA binding site [nucleotide binding]; other site 762570007291 putative Zn2+ binding site [ion binding]; other site 762570007292 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762570007293 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762570007294 metal-binding site [ion binding] 762570007295 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762570007296 Soluble P-type ATPase [General function prediction only]; Region: COG4087 762570007297 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 762570007298 Clp amino terminal domain; Region: Clp_N; pfam02861 762570007299 Clp amino terminal domain; Region: Clp_N; pfam02861 762570007300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570007301 Walker A motif; other site 762570007302 ATP binding site [chemical binding]; other site 762570007303 Walker B motif; other site 762570007304 arginine finger; other site 762570007305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570007306 Walker A motif; other site 762570007307 ATP binding site [chemical binding]; other site 762570007308 Walker B motif; other site 762570007309 arginine finger; other site 762570007310 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762570007311 Abhydrolase family; Region: Abhydrolase_7; pfam12715 762570007312 Dienelactone hydrolase family; Region: DLH; pfam01738 762570007313 putative pectinesterase; Region: PLN02432; cl01911 762570007314 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 762570007315 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 762570007316 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570007317 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 762570007318 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570007319 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570007320 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 762570007321 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 762570007322 GTP binding site; other site 762570007323 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762570007324 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 762570007325 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570007326 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570007327 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 762570007328 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570007329 glycyl-tRNA synthetase; Provisional; Region: PRK04173 762570007330 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762570007331 motif 1; other site 762570007332 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 762570007333 active site 762570007334 motif 2; other site 762570007335 motif 3; other site 762570007336 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 762570007337 anticodon binding site; other site 762570007338 hypothetical protein; Reviewed; Region: PRK00024 762570007339 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 762570007340 helix-hairpin-helix signature motif; other site 762570007341 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 762570007342 MPN+ (JAMM) motif; other site 762570007343 Zinc-binding site [ion binding]; other site 762570007344 transcription termination factor Rho; Provisional; Region: PRK12608 762570007345 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762570007346 RNA binding site [nucleotide binding]; other site 762570007347 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762570007348 Walker A motif; other site 762570007349 ATP binding site [chemical binding]; other site 762570007350 Walker B motif; other site 762570007351 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 762570007352 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762570007353 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 762570007354 catalytic site [active] 762570007355 TAP-like protein; Region: Abhydrolase_4; pfam08386 762570007356 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 762570007357 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 762570007358 UPF0278 family; Region: UPF0278; cl17319 762570007359 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 762570007360 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 762570007361 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762570007362 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762570007363 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 762570007364 putative active site [active] 762570007365 YdjC motif; other site 762570007366 Mg binding site [ion binding]; other site 762570007367 homodimer interface [polypeptide binding]; other site 762570007368 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 762570007369 RNA/DNA hybrid binding site [nucleotide binding]; other site 762570007370 active site 762570007371 shikimate kinase; Reviewed; Region: aroK; PRK00131 762570007372 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 762570007373 ADP binding site [chemical binding]; other site 762570007374 magnesium binding site [ion binding]; other site 762570007375 putative shikimate binding site; other site 762570007376 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 762570007377 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 762570007378 dimerization interface 3.5A [polypeptide binding]; other site 762570007379 active site 762570007380 Amidinotransferase; Region: Amidinotransf; cl12043 762570007381 HEPN domain; Region: HEPN; cl00824 762570007382 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570007383 active site 762570007384 NTP binding site [chemical binding]; other site 762570007385 metal binding triad [ion binding]; metal-binding site 762570007386 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 762570007387 putative active site [active] 762570007388 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 762570007389 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 762570007390 nucleoside/Zn binding site; other site 762570007391 dimer interface [polypeptide binding]; other site 762570007392 catalytic motif [active] 762570007393 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 762570007394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 762570007395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762570007396 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570007397 active site 762570007398 NTP binding site [chemical binding]; other site 762570007399 metal binding triad [ion binding]; metal-binding site 762570007400 antibiotic binding site [chemical binding]; other site 762570007401 Protein of unknown function DUF86; Region: DUF86; cl01031 762570007402 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 762570007403 G1 box; other site 762570007404 GTP/Mg2+ binding site [chemical binding]; other site 762570007405 Switch I region; other site 762570007406 G2 box; other site 762570007407 G3 box; other site 762570007408 Switch II region; other site 762570007409 G4 box; other site 762570007410 G5 box; other site 762570007411 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 762570007412 CoA binding domain; Region: CoA_binding; smart00881 762570007413 CoA-ligase; Region: Ligase_CoA; pfam00549 762570007414 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762570007415 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 762570007416 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 762570007417 adenosine deaminase; Provisional; Region: PRK09358 762570007418 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 762570007419 active site 762570007420 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 762570007421 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 762570007422 hinge; other site 762570007423 active site 762570007424 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 762570007425 oligomeric interface; other site 762570007426 putative active site [active] 762570007427 homodimer interface [polypeptide binding]; other site 762570007428 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 762570007429 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 762570007430 DNA binding site [nucleotide binding] 762570007431 active site 762570007432 starch binding outer membrane protein SusD; Region: SusD; cl17845 762570007433 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 762570007434 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570007435 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570007436 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 762570007437 FAD binding domain; Region: FAD_binding_4; pfam01565 762570007438 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 762570007439 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762570007440 PGAP1-like protein; Region: PGAP1; pfam07819 762570007441 chaperone protein DnaJ; Provisional; Region: PRK14299 762570007442 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 762570007443 HSP70 interaction site [polypeptide binding]; other site 762570007444 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 762570007445 substrate binding site [polypeptide binding]; other site 762570007446 dimer interface [polypeptide binding]; other site 762570007447 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 762570007448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570007449 S-adenosylmethionine binding site [chemical binding]; other site 762570007450 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 762570007451 RNB domain; Region: RNB; pfam00773 762570007452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 762570007453 Protein of unknown function (DUF433); Region: DUF433; pfam04255 762570007454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570007455 S-adenosylmethionine binding site [chemical binding]; other site 762570007456 Response regulator receiver domain; Region: Response_reg; pfam00072 762570007457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570007458 active site 762570007459 phosphorylation site [posttranslational modification] 762570007460 intermolecular recognition site; other site 762570007461 dimerization interface [polypeptide binding]; other site 762570007462 PglZ domain; Region: PglZ; pfam08665 762570007463 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 762570007464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762570007465 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762570007466 NAD(P) binding site [chemical binding]; other site 762570007467 active site 762570007468 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 762570007469 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 762570007470 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 762570007471 PA/protease or protease-like domain interface [polypeptide binding]; other site 762570007472 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 762570007473 metal binding site [ion binding]; metal-binding site 762570007474 Predicted dehydrogenase [General function prediction only]; Region: COG0579 762570007475 hydroxyglutarate oxidase; Provisional; Region: PRK11728 762570007476 metal-dependent hydrolase; Provisional; Region: PRK13291 762570007477 DinB superfamily; Region: DinB_2; pfam12867 762570007478 MjaI restriction endonuclease; Region: RE_MjaI; pfam09568 762570007479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570007480 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 762570007481 DNA methylase; Region: N6_N4_Mtase; pfam01555 762570007482 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 762570007483 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 762570007484 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 762570007485 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 762570007486 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 762570007487 Nitrogen regulatory protein P-II; Region: P-II; smart00938 762570007488 Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503 762570007489 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 762570007490 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762570007491 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 762570007492 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 762570007493 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762570007494 FtsX-like permease family; Region: FtsX; pfam02687 762570007495 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762570007496 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762570007497 Walker A/P-loop; other site 762570007498 ATP binding site [chemical binding]; other site 762570007499 Q-loop/lid; other site 762570007500 ABC transporter signature motif; other site 762570007501 Walker B; other site 762570007502 D-loop; other site 762570007503 H-loop/switch region; other site 762570007504 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 762570007505 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762570007506 FeS/SAM binding site; other site 762570007507 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 762570007508 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 762570007509 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 762570007510 protein-splicing catalytic site; other site 762570007511 thioester formation/cholesterol transfer; other site 762570007512 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 762570007513 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 762570007514 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 762570007515 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 762570007516 protein-splicing catalytic site; other site 762570007517 thioester formation/cholesterol transfer; other site 762570007518 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 762570007519 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 762570007520 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 762570007521 TSCPD domain; Region: TSCPD; pfam12637 762570007522 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 762570007523 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 762570007524 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 762570007525 active site 762570007526 NTP binding site [chemical binding]; other site 762570007527 metal binding triad [ion binding]; metal-binding site 762570007528 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 762570007529 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762570007530 Zn2+ binding site [ion binding]; other site 762570007531 Mg2+ binding site [ion binding]; other site 762570007532 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 762570007533 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 762570007534 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 762570007535 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762570007536 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 762570007537 putative ADP-ribose binding site [chemical binding]; other site 762570007538 putative active site [active] 762570007539 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 762570007540 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 762570007541 dimer interface [polypeptide binding]; other site 762570007542 active site 762570007543 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 762570007544 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 762570007545 putative active site [active] 762570007546 substrate binding site [chemical binding]; other site 762570007547 putative cosubstrate binding site; other site 762570007548 catalytic site [active] 762570007549 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 762570007550 substrate binding site [chemical binding]; other site 762570007551 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 762570007552 MoxR-like ATPases [General function prediction only]; Region: COG0714 762570007553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570007554 Walker A motif; other site 762570007555 ATP binding site [chemical binding]; other site 762570007556 Walker B motif; other site 762570007557 arginine finger; other site 762570007558 HPr kinase/phosphorylase; Provisional; Region: PRK05428 762570007559 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 762570007560 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 762570007561 Hpr binding site; other site 762570007562 active site 762570007563 homohexamer subunit interaction site [polypeptide binding]; other site 762570007564 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 762570007565 Peptidase family M23; Region: Peptidase_M23; pfam01551 762570007566 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 762570007567 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 762570007568 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 762570007569 Surface antigen; Region: Bac_surface_Ag; pfam01103 762570007570 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762570007571 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762570007572 ligand binding site [chemical binding]; other site 762570007573 flexible hinge region; other site 762570007574 TRAM domain; Region: TRAM; cl01282 762570007575 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 762570007576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570007577 S-adenosylmethionine binding site [chemical binding]; other site 762570007578 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 762570007579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762570007580 NAD(P) binding site [chemical binding]; other site 762570007581 active site 762570007582 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762570007583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762570007584 putative substrate translocation pore; other site 762570007585 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570007586 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570007587 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570007588 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570007589 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 762570007590 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762570007591 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 762570007592 DHH family; Region: DHH; pfam01368 762570007593 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 762570007594 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 762570007595 potassium/proton antiporter; Reviewed; Region: PRK05326 762570007596 TrkA-C domain; Region: TrkA_C; pfam02080 762570007597 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570007598 active site 762570007599 NTP binding site [chemical binding]; other site 762570007600 metal binding triad [ion binding]; metal-binding site 762570007601 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 762570007602 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 762570007603 FeoA domain; Region: FeoA; cl00838 762570007604 FeoA domain; Region: FeoA; pfam04023 762570007605 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 762570007606 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 762570007607 G1 box; other site 762570007608 GTP/Mg2+ binding site [chemical binding]; other site 762570007609 Switch I region; other site 762570007610 G2 box; other site 762570007611 G3 box; other site 762570007612 Switch II region; other site 762570007613 G4 box; other site 762570007614 G5 box; other site 762570007615 Nucleoside recognition; Region: Gate; pfam07670 762570007616 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 762570007617 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 762570007618 Nucleoside recognition; Region: Gate; pfam07670 762570007619 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 762570007620 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762570007621 CAAX protease self-immunity; Region: Abi; pfam02517 762570007622 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570007623 active site 762570007624 NTP binding site [chemical binding]; other site 762570007625 metal binding triad [ion binding]; metal-binding site 762570007626 antibiotic binding site [chemical binding]; other site 762570007627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570007628 S-adenosylmethionine binding site [chemical binding]; other site 762570007629 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570007630 active site 762570007631 NTP binding site [chemical binding]; other site 762570007632 metal binding triad [ion binding]; metal-binding site 762570007633 antibiotic binding site [chemical binding]; other site 762570007634 Homeodomain-like domain; Region: HTH_23; pfam13384 762570007635 Winged helix-turn helix; Region: HTH_29; pfam13551 762570007636 Homeodomain-like domain; Region: HTH_32; pfam13565 762570007637 DDE superfamily endonuclease; Region: DDE_3; pfam13358 762570007638 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 762570007639 high affinity sulphate transporter 1; Region: sulP; TIGR00815 762570007640 Sulfate transporter family; Region: Sulfate_transp; pfam00916 762570007641 Sulfate transporter family; Region: Sulfate_transp; pfam00916 762570007642 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 762570007643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 762570007644 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 762570007645 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762570007646 Methyltransferase domain; Region: Methyltransf_31; pfam13847 762570007647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570007648 S-adenosylmethionine binding site [chemical binding]; other site 762570007649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762570007650 Coenzyme A binding pocket [chemical binding]; other site 762570007651 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762570007652 dimerization interface [polypeptide binding]; other site 762570007653 putative DNA binding site [nucleotide binding]; other site 762570007654 putative Zn2+ binding site [ion binding]; other site 762570007655 HupE / UreJ protein; Region: HupE_UreJ; cl01011 762570007656 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762570007657 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 762570007658 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 762570007659 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762570007660 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762570007661 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 762570007662 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 762570007663 4Fe-4S binding domain; Region: Fer4; pfam00037 762570007664 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 762570007665 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 762570007666 dimer interface [polypeptide binding]; other site 762570007667 PYR/PP interface [polypeptide binding]; other site 762570007668 TPP binding site [chemical binding]; other site 762570007669 substrate binding site [chemical binding]; other site 762570007670 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 762570007671 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 762570007672 TPP-binding site [chemical binding]; other site 762570007673 putative dimer interface [polypeptide binding]; other site 762570007674 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 762570007675 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762570007676 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762570007677 ligand binding site [chemical binding]; other site 762570007678 flexible hinge region; other site 762570007679 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 762570007680 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 762570007681 FAD binding pocket [chemical binding]; other site 762570007682 FAD binding motif [chemical binding]; other site 762570007683 phosphate binding motif [ion binding]; other site 762570007684 beta-alpha-beta structure motif; other site 762570007685 NAD binding pocket [chemical binding]; other site 762570007686 Iron coordination center [ion binding]; other site 762570007687 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 762570007688 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 762570007689 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 762570007690 nickel binding site [ion binding]; other site 762570007691 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 762570007692 Acylphosphatase; Region: Acylphosphatase; pfam00708 762570007693 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 762570007694 HypF finger; Region: zf-HYPF; pfam07503 762570007695 HypF finger; Region: zf-HYPF; pfam07503 762570007696 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 762570007697 HupF/HypC family; Region: HupF_HypC; pfam01455 762570007698 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 762570007699 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 762570007700 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 762570007701 dimerization interface [polypeptide binding]; other site 762570007702 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 762570007703 ATP binding site [chemical binding]; other site 762570007704 alpha-galactosidase; Region: PLN02808; cl17638 762570007705 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762570007706 Tetratricopeptide repeat; Region: TPR_12; pfam13424 762570007707 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 762570007708 metal ion-dependent adhesion site (MIDAS); other site 762570007709 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 762570007710 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 762570007711 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 762570007712 Na binding site [ion binding]; other site 762570007713 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 762570007714 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 762570007715 active site 762570007716 homotrimer interface [polypeptide binding]; other site 762570007717 catalytic site [active] 762570007718 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 762570007719 thymidine kinase; Provisional; Region: PRK04296 762570007720 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 762570007721 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 762570007722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570007723 Walker A motif; other site 762570007724 ATP binding site [chemical binding]; other site 762570007725 Walker B motif; other site 762570007726 arginine finger; other site 762570007727 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 762570007728 Protein of unknown function (DUF721); Region: DUF721; pfam05258 762570007729 hypothetical protein; Validated; Region: PRK00153 762570007730 recombination protein RecR; Reviewed; Region: recR; PRK00076 762570007731 RecR protein; Region: RecR; pfam02132 762570007732 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 762570007733 putative active site [active] 762570007734 putative metal-binding site [ion binding]; other site 762570007735 tetramer interface [polypeptide binding]; other site 762570007736 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 762570007737 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762570007738 classical (c) SDRs; Region: SDR_c; cd05233 762570007739 NAD(P) binding site [chemical binding]; other site 762570007740 active site 762570007741 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 762570007742 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570007743 putative ADP-binding pocket [chemical binding]; other site 762570007744 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 762570007745 Domain of unknown function (DUF377); Region: DUF377; pfam04041 762570007746 active site 762570007747 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 762570007748 active site 762570007749 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 762570007750 active site 762570007751 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 762570007752 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 762570007753 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 762570007754 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 762570007755 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570007756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570007757 DNA binding residues [nucleotide binding] 762570007758 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 762570007759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570007760 S-adenosylmethionine binding site [chemical binding]; other site 762570007761 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 762570007762 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 762570007763 Ferritin-like domain; Region: Ferritin; pfam00210 762570007764 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 762570007765 dinuclear metal binding motif [ion binding]; other site 762570007766 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 762570007767 putative catalytic site [active] 762570007768 putative phosphate binding site [ion binding]; other site 762570007769 active site 762570007770 metal binding site A [ion binding]; metal-binding site 762570007771 DNA binding site [nucleotide binding] 762570007772 putative AP binding site [nucleotide binding]; other site 762570007773 putative metal binding site B [ion binding]; other site 762570007774 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 762570007775 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 762570007776 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 762570007777 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 762570007778 SLBB domain; Region: SLBB; pfam10531 762570007779 Chain length determinant protein; Region: Wzz; cl15801 762570007780 Surface antigen; Region: Bac_surface_Ag; pfam01103 762570007781 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 762570007782 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762570007783 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762570007784 DNA binding residues [nucleotide binding] 762570007785 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 762570007786 DNA polymerase III, delta subunit; Region: holA; TIGR01128 762570007787 DinB superfamily; Region: DinB_2; pfam12867 762570007788 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 762570007789 4Fe-4S binding domain; Region: Fer4; cl02805 762570007790 4Fe-4S binding domain; Region: Fer4; pfam00037 762570007791 GTP-binding protein Der; Reviewed; Region: PRK00093 762570007792 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 762570007793 G1 box; other site 762570007794 GTP/Mg2+ binding site [chemical binding]; other site 762570007795 Switch I region; other site 762570007796 G2 box; other site 762570007797 Switch II region; other site 762570007798 G3 box; other site 762570007799 G4 box; other site 762570007800 G5 box; other site 762570007801 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 762570007802 G1 box; other site 762570007803 GTP/Mg2+ binding site [chemical binding]; other site 762570007804 Switch I region; other site 762570007805 G2 box; other site 762570007806 G3 box; other site 762570007807 Switch II region; other site 762570007808 G4 box; other site 762570007809 G5 box; other site 762570007810 EcsC protein family; Region: EcsC; pfam12787 762570007811 Bacitracin resistance protein BacA; Region: BacA; pfam02673 762570007812 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 762570007813 Domain of unknown function (DUF814); Region: DUF814; pfam05670 762570007814 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 762570007815 Protein of unknown function (DUF433); Region: DUF433; pfam04255 762570007816 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 762570007817 short chain dehydrogenase; Provisional; Region: PRK07326 762570007818 classical (c) SDRs; Region: SDR_c; cd05233 762570007819 NAD(P) binding site [chemical binding]; other site 762570007820 active site 762570007821 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 762570007822 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 762570007823 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 762570007824 Penicillinase repressor; Region: Pencillinase_R; pfam03965 762570007825 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 762570007826 active site 762570007827 catalytic triad [active] 762570007828 oxyanion hole [active] 762570007829 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 762570007830 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 762570007831 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 762570007832 DinB superfamily; Region: DinB_2; pfam12867 762570007833 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 762570007834 Serine hydrolase (FSH1); Region: FSH1; pfam03959 762570007835 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 762570007836 DctM-like transporters; Region: DctM; pfam06808 762570007837 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 762570007838 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 762570007839 4Fe-4S binding domain; Region: Fer4; cl02805 762570007840 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 762570007841 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 762570007842 active site 762570007843 dimer interfaces [polypeptide binding]; other site 762570007844 catalytic residues [active] 762570007845 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 762570007846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762570007847 Walker A motif; other site 762570007848 ATP binding site [chemical binding]; other site 762570007849 Walker B motif; other site 762570007850 arginine finger; other site 762570007851 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 762570007852 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 762570007853 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 762570007854 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 762570007855 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 762570007856 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 762570007857 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762570007858 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762570007859 catalytic residue [active] 762570007860 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 762570007861 active site 762570007862 catalytic residues [active] 762570007863 metal binding site [ion binding]; metal-binding site 762570007864 glycine dehydrogenase; Provisional; Region: PRK05367 762570007865 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 762570007866 tetramer interface [polypeptide binding]; other site 762570007867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570007868 catalytic residue [active] 762570007869 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 762570007870 tetramer interface [polypeptide binding]; other site 762570007871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762570007872 catalytic residue [active] 762570007873 Protein of unknown function DUF89; Region: DUF89; pfam01937 762570007874 ribonuclease III; Reviewed; Region: rnc; PRK00102 762570007875 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 762570007876 dimerization interface [polypeptide binding]; other site 762570007877 active site 762570007878 metal binding site [ion binding]; metal-binding site 762570007879 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 762570007880 dsRNA binding site [nucleotide binding]; other site 762570007881 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 762570007882 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762570007883 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762570007884 LabA_like proteins; Region: LabA_like; cd06167 762570007885 putative metal binding site [ion binding]; other site 762570007886 Nitrogen regulatory protein P-II; Region: P-II; cl00412 762570007887 Domain of unknown function (DUF897); Region: DUF897; pfam05982 762570007888 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 762570007889 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 762570007890 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 762570007891 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 762570007892 TrkA-N domain; Region: TrkA_N; pfam02254 762570007893 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 762570007894 active site 762570007895 phosphorylation site [posttranslational modification] 762570007896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570007897 dimer interface [polypeptide binding]; other site 762570007898 phosphorylation site [posttranslational modification] 762570007899 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 762570007900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570007901 ATP binding site [chemical binding]; other site 762570007902 Mg2+ binding site [ion binding]; other site 762570007903 G-X-G motif; other site 762570007904 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762570007905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762570007906 active site 762570007907 phosphorylation site [posttranslational modification] 762570007908 intermolecular recognition site; other site 762570007909 dimerization interface [polypeptide binding]; other site 762570007910 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762570007911 DNA binding site [nucleotide binding] 762570007912 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 762570007913 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 762570007914 Uncharacterized conserved protein [Function unknown]; Region: COG3391 762570007915 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 762570007916 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 762570007917 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570007918 MarR family; Region: MarR_2; cl17246 762570007919 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762570007920 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 762570007921 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 762570007922 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 762570007923 homodimer interface [polypeptide binding]; other site 762570007924 substrate-cofactor binding pocket; other site 762570007925 catalytic residue [active] 762570007926 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 762570007927 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762570007928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762570007929 Coenzyme A binding pocket [chemical binding]; other site 762570007930 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 762570007931 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 762570007932 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 762570007933 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 762570007934 protein binding site [polypeptide binding]; other site 762570007935 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 762570007936 pseudouridine synthase; Region: TIGR00093 762570007937 active site 762570007938 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 762570007939 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 762570007940 homotetramer interface [polypeptide binding]; other site 762570007941 ligand binding site [chemical binding]; other site 762570007942 catalytic site [active] 762570007943 NAD binding site [chemical binding]; other site 762570007944 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 762570007945 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 762570007946 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 762570007947 Zn binding site [ion binding]; other site 762570007948 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570007949 S-adenosylmethionine synthetase; Validated; Region: PRK05250 762570007950 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 762570007951 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 762570007952 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 762570007953 acyl carrier protein; Provisional; Region: acpP; PRK00982 762570007954 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 762570007955 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 762570007956 dimer interface [polypeptide binding]; other site 762570007957 active site 762570007958 Protein of unknown function (DUF721); Region: DUF721; pfam05258 762570007959 Outer membrane efflux protein; Region: OEP; pfam02321 762570007960 Outer membrane efflux protein; Region: OEP; pfam02321 762570007961 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 762570007962 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762570007963 active site 762570007964 beta-D-glucuronidase; Provisional; Region: PRK10150 762570007965 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 762570007966 cell division protein FtsZ; Validated; Region: PRK09330 762570007967 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 762570007968 nucleotide binding site [chemical binding]; other site 762570007969 SulA interaction site; other site 762570007970 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 762570007971 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762570007972 nucleotide binding site [chemical binding]; other site 762570007973 Cell division protein FtsA; Region: FtsA; pfam14450 762570007974 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 762570007975 Cell division protein FtsQ; Region: FtsQ; pfam03799 762570007976 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 762570007977 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762570007978 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762570007979 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762570007980 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 762570007981 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 762570007982 active site 762570007983 homodimer interface [polypeptide binding]; other site 762570007984 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 762570007985 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 762570007986 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762570007987 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762570007988 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762570007989 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 762570007990 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 762570007991 Mg++ binding site [ion binding]; other site 762570007992 putative catalytic motif [active] 762570007993 putative substrate binding site [chemical binding]; other site 762570007994 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 762570007995 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762570007996 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762570007997 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762570007998 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 762570007999 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 762570008000 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 762570008001 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 762570008002 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 762570008003 MraW methylase family; Region: Methyltransf_5; cl17771 762570008004 cell division protein MraZ; Reviewed; Region: PRK00326 762570008005 MraZ protein; Region: MraZ; pfam02381 762570008006 MraZ protein; Region: MraZ; pfam02381 762570008007 LexA repressor; Validated; Region: PRK00215 762570008008 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 762570008009 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 762570008010 Catalytic site [active] 762570008011 CTP synthetase; Validated; Region: pyrG; PRK05380 762570008012 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 762570008013 Catalytic site [active] 762570008014 active site 762570008015 UTP binding site [chemical binding]; other site 762570008016 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 762570008017 active site 762570008018 putative oxyanion hole; other site 762570008019 catalytic triad [active] 762570008020 Methyltransferase domain; Region: Methyltransf_31; pfam13847 762570008021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570008022 S-adenosylmethionine binding site [chemical binding]; other site 762570008023 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570008024 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 762570008025 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 762570008026 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 762570008027 Ligand binding site; other site 762570008028 Putative Catalytic site; other site 762570008029 DXD motif; other site 762570008030 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 762570008031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570008032 ATP binding site [chemical binding]; other site 762570008033 Mg2+ binding site [ion binding]; other site 762570008034 G-X-G motif; other site 762570008035 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 762570008036 anchoring element; other site 762570008037 dimer interface [polypeptide binding]; other site 762570008038 ATP binding site [chemical binding]; other site 762570008039 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 762570008040 active site 762570008041 putative metal-binding site [ion binding]; other site 762570008042 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 762570008043 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762570008044 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 762570008045 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 762570008046 active site 762570008047 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 762570008048 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 762570008049 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 762570008050 HflX GTPase family; Region: HflX; cd01878 762570008051 G1 box; other site 762570008052 GTP/Mg2+ binding site [chemical binding]; other site 762570008053 Switch I region; other site 762570008054 G2 box; other site 762570008055 G3 box; other site 762570008056 Switch II region; other site 762570008057 G4 box; other site 762570008058 G5 box; other site 762570008059 Aerotolerance regulator N-terminal; Region: BatA; cl06567 762570008060 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 762570008061 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762570008062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762570008063 S-adenosylmethionine binding site [chemical binding]; other site 762570008064 HDOD domain; Region: HDOD; pfam08668 762570008065 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 762570008066 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 762570008067 Cupin domain; Region: Cupin_2; pfam07883 762570008068 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 762570008069 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 762570008070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762570008071 ABC transporter signature motif; other site 762570008072 Walker B; other site 762570008073 D-loop; other site 762570008074 H-loop/switch region; other site 762570008075 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 762570008076 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570008077 active site 762570008078 NTP binding site [chemical binding]; other site 762570008079 metal binding triad [ion binding]; metal-binding site 762570008080 antibiotic binding site [chemical binding]; other site 762570008081 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 762570008082 methionine sulfoxide reductase A; Provisional; Region: PRK14054 762570008083 MarR family; Region: MarR_2; cl17246 762570008084 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762570008085 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 762570008086 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762570008087 HlyD family secretion protein; Region: HlyD_3; pfam13437 762570008088 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762570008089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762570008090 putative substrate translocation pore; other site 762570008091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762570008092 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 762570008093 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570008094 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 762570008095 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570008096 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 762570008097 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 762570008098 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 762570008099 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 762570008100 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 762570008101 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762570008102 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762570008103 transcriptional regulator EutR; Provisional; Region: PRK10130 762570008104 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 762570008105 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762570008106 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762570008107 active site 762570008108 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 762570008109 dimer interaction site [polypeptide binding]; other site 762570008110 substrate-binding tunnel; other site 762570008111 active site 762570008112 catalytic site [active] 762570008113 substrate binding site [chemical binding]; other site 762570008114 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 762570008115 Peptidase family M48; Region: Peptidase_M48; cl12018 762570008116 recombination protein F; Reviewed; Region: recF; PRK00064 762570008117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762570008118 Walker A/P-loop; other site 762570008119 ATP binding site [chemical binding]; other site 762570008120 Q-loop/lid; other site 762570008121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762570008122 ABC transporter signature motif; other site 762570008123 Walker B; other site 762570008124 D-loop; other site 762570008125 H-loop/switch region; other site 762570008126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570008127 TPR motif; other site 762570008128 binding surface 762570008129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762570008130 binding surface 762570008131 TPR motif; other site 762570008132 CHAT domain; Region: CHAT; pfam12770 762570008133 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 762570008134 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 762570008135 putative active site [active] 762570008136 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 762570008137 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 762570008138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762570008139 ATP binding site [chemical binding]; other site 762570008140 putative Mg++ binding site [ion binding]; other site 762570008141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762570008142 nucleotide binding region [chemical binding]; other site 762570008143 ATP-binding site [chemical binding]; other site 762570008144 TRCF domain; Region: TRCF; pfam03461 762570008145 Predicted transcriptional regulator [Transcription]; Region: COG2378 762570008146 HTH domain; Region: HTH_11; pfam08279 762570008147 WYL domain; Region: WYL; pfam13280 762570008148 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 762570008149 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 762570008150 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 762570008151 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 762570008152 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 762570008153 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 762570008154 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 762570008155 PAS domain S-box; Region: sensory_box; TIGR00229 762570008156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570008157 putative active site [active] 762570008158 heme pocket [chemical binding]; other site 762570008159 PAS domain S-box; Region: sensory_box; TIGR00229 762570008160 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570008161 putative active site [active] 762570008162 heme pocket [chemical binding]; other site 762570008163 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 762570008164 GAF domain; Region: GAF; pfam01590 762570008165 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 762570008166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762570008167 putative active site [active] 762570008168 heme pocket [chemical binding]; other site 762570008169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762570008170 dimer interface [polypeptide binding]; other site 762570008171 phosphorylation site [posttranslational modification] 762570008172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762570008173 ATP binding site [chemical binding]; other site 762570008174 Mg2+ binding site [ion binding]; other site 762570008175 G-X-G motif; other site 762570008176 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 762570008177 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 762570008178 trmE is a tRNA modification GTPase; Region: trmE; cd04164 762570008179 G1 box; other site 762570008180 GTP/Mg2+ binding site [chemical binding]; other site 762570008181 Switch I region; other site 762570008182 G2 box; other site 762570008183 Switch II region; other site 762570008184 G3 box; other site 762570008185 G4 box; other site 762570008186 G5 box; other site 762570008187 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 762570008188 membrane protein insertase; Provisional; Region: PRK01318 762570008189 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 762570008190 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 762570008191 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 762570008192 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 762570008193 FAD binding domain; Region: FAD_binding_4; pfam01565 762570008194 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 762570008195 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 762570008196 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762570008197 catalytic loop [active] 762570008198 iron binding site [ion binding]; other site 762570008199 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 762570008200 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 762570008201 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 762570008202 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 762570008203 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 762570008204 putative hydrophobic ligand binding site [chemical binding]; other site 762570008205 MoxR-like ATPases [General function prediction only]; Region: COG0714 762570008206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 762570008207 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 762570008208 metal ion-dependent adhesion site (MIDAS); other site 762570008209 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 762570008210 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 762570008211 XdhC Rossmann domain; Region: XdhC_C; pfam13478 762570008212 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762570008213 metal-binding site [ion binding] 762570008214 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 762570008215 Ligand binding site; other site 762570008216 metal-binding site 762570008217 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 762570008218 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 762570008219 XdhC Rossmann domain; Region: XdhC_C; pfam13478 762570008220 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 762570008221 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 762570008222 tetramer interface [polypeptide binding]; other site 762570008223 heme binding pocket [chemical binding]; other site 762570008224 NADPH binding site [chemical binding]; other site 762570008225 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762570008226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762570008227 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 762570008228 dimerization interface [polypeptide binding]; other site 762570008229 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 762570008230 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 762570008231 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762570008232 dimerization interface [polypeptide binding]; other site 762570008233 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762570008234 dimer interface [polypeptide binding]; other site 762570008235 putative CheW interface [polypeptide binding]; other site 762570008236 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 762570008237 dimanganese center [ion binding]; other site 762570008238 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762570008239 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 762570008240 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570008241 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762570008242 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762570008243 N-terminal plug; other site 762570008244 ligand-binding site [chemical binding]; other site 762570008245 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 762570008246 MgtE intracellular N domain; Region: MgtE_N; smart00924 762570008247 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 762570008248 Divalent cation transporter; Region: MgtE; pfam01769 762570008249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 762570008250 TPR motif; other site 762570008251 binding surface 762570008252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762570008253 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762570008254 DNA binding site [nucleotide binding] 762570008255 domain linker motif; other site 762570008256 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762570008257 ligand binding site [chemical binding]; other site 762570008258 dimerization interface [polypeptide binding]; other site 762570008259 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 762570008260 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 762570008261 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762570008262 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 762570008263 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 762570008264 active site 762570008265 trimer interface [polypeptide binding]; other site 762570008266 allosteric site; other site 762570008267 active site lid [active] 762570008268 hexamer (dimer of trimers) interface [polypeptide binding]; other site 762570008269 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 762570008270 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 762570008271 putative ligand binding site [chemical binding]; other site 762570008272 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 762570008273 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 762570008274 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762570008275 nucleotide binding site [chemical binding]; other site 762570008276 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 762570008277 Cna protein B-type domain; Region: Cna_B_2; pfam13715 762570008278 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 762570008279 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762570008280 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 762570008281 starch binding outer membrane protein SusD; Region: SusD; cl17845 762570008282 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 762570008283 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 762570008284 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 762570008285 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 762570008286 active site 762570008287 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 762570008288 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 762570008289 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 762570008290 catalytic triad [active] 762570008291 Protein of unknown function, DUF399; Region: DUF399; pfam04187 762570008292 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 762570008293 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762570008294 ATP binding site [chemical binding]; other site 762570008295 Mg++ binding site [ion binding]; other site 762570008296 motif III; other site 762570008297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762570008298 nucleotide binding region [chemical binding]; other site 762570008299 ATP-binding site [chemical binding]; other site 762570008300 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 762570008301 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 762570008302 NAD(P) binding site [chemical binding]; other site 762570008303 homotetramer interface [polypeptide binding]; other site 762570008304 homodimer interface [polypeptide binding]; other site 762570008305 active site 762570008306 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 762570008307 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 762570008308 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 762570008309 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 762570008310 dimer interface [polypeptide binding]; other site 762570008311 active site 762570008312 CoA binding pocket [chemical binding]; other site 762570008313 putative phosphate acyltransferase; Provisional; Region: PRK05331 762570008314 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 762570008315 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 762570008316 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 762570008317 AAA domain; Region: AAA_30; pfam13604 762570008318 Family description; Region: UvrD_C_2; pfam13538 762570008319 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762570008320 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 762570008321 P-loop; other site 762570008322 Magnesium ion binding site [ion binding]; other site 762570008323 Homeodomain-like domain; Region: HTH_23; pfam13384 762570008324 Winged helix-turn helix; Region: HTH_29; pfam13551 762570008325 Homeodomain-like domain; Region: HTH_32; pfam13565 762570008326 DDE superfamily endonuclease; Region: DDE_3; pfam13358 762570008327 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 762570008328 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 762570008329 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 762570008330 Predicted transcriptional regulator [Transcription]; Region: COG2378 762570008331 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762570008332 putative DNA binding site [nucleotide binding]; other site 762570008333 putative Zn2+ binding site [ion binding]; other site 762570008334 WYL domain; Region: WYL; pfam13280 762570008335 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 762570008336 DNA methylase; Region: N6_N4_Mtase; pfam01555 762570008337 DNA methylase; Region: N6_N4_Mtase; cl17433 762570008338 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 762570008339 active site 762570008340 NTP binding site [chemical binding]; other site 762570008341 metal binding triad [ion binding]; metal-binding site 762570008342 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762570008343 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762570008344 ATP binding site [chemical binding]; other site 762570008345 putative Mg++ binding site [ion binding]; other site 762570008346 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 762570008347 GIY-YIG motif/motif A; other site 762570008348 putative active site [active] 762570008349 putative metal binding site [ion binding]; other site 762570008350 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 762570008351 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 762570008352 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 762570008353 Catalytic site [active] 762570008354 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 762570008355 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 762570008356 active site 762570008357 DNA binding site [nucleotide binding] 762570008358 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 762570008359 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 762570008360 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 762570008361 catalytic residues [active] 762570008362 catalytic nucleophile [active] 762570008363 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 762570008364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 762570008365 Probable transposase; Region: OrfB_IS605; pfam01385 762570008366 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 762570008367 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 762570008368 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 762570008369 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 762570008370 fatty aldehyde decarbonylase; Region: PLN02869 762570008371 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 762570008372 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 762570008373 metal ion-dependent adhesion site (MIDAS); other site 762570008374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 762570008375 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 762570008376 Probable transposase; Region: OrfB_IS605; pfam01385 762570008377 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 762570008378 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 762570008379 Family description; Region: VCBS; pfam13517 762570008380 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 762570008381 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 762570008382 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 762570008383 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 762570008384 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 762570008385 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 762570008386 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839 762570008387 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 762570008388 DNA binding residues [nucleotide binding] 762570008389 dimerization interface [polypeptide binding]; other site 762570008390 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 762570008391 JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744 762570008392 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 762570008393 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 762570008394 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 762570008395 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839 762570008396 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 762570008397 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 762570008398 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 762570008399 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 762570008400 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 762570008401 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 762570008402 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 762570008403 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 762570008404 AAA domain; Region: AAA_30; pfam13604 762570008405 AAA domain; Region: AAA_22; pfam13401 762570008406 Family description; Region: UvrD_C_2; pfam13538 762570008407 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 762570008408 CRISPR-associated protein, TIGR02710 family; Region: TIGR02710 762570008409 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762570008410 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 762570008411 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 762570008412 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762570008413 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762570008414 ATP binding site [chemical binding]; other site 762570008415 putative Mg++ binding site [ion binding]; other site 762570008416 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 762570008417 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762570008418 ATP-binding site [chemical binding]; other site 762570008419 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 762570008420 active site 762570008421 substrate binding site [chemical binding]; other site 762570008422 catalytic site [active] 762570008423 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 762570008424 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 762570008425 Probable transposase; Region: OrfB_IS605; pfam01385 762570008426 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 762570008427 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 762570008428 putative active site [active] 762570008429 homotetrameric interface [polypeptide binding]; other site 762570008430 metal binding site [ion binding]; metal-binding site 762570008431 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 762570008432 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 762570008433 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762570008434 active site 762570008435 NTP binding site [chemical binding]; other site 762570008436 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 762570008437 CHASE3 domain; Region: CHASE3; pfam05227 762570008438 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 762570008439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762570008440 dimerization interface [polypeptide binding]; other site 762570008441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762570008442 dimerization interface [polypeptide binding]; other site 762570008443 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762570008444 dimer interface [polypeptide binding]; other site 762570008445 putative CheW interface [polypeptide binding]; other site