-- dump date 20140620_033339 -- class Genbank::CDS -- table cds_note -- id note YP_001492846.1 COG1806 Uncharacterized protein conserved in bacteria YP_001492847.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_001492848.1 COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component YP_001492849.1 COG1682 ABC-type polysaccharide/polyol phosphate export systems, permease component YP_001492850.1 undetermined function YP_001492851.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_001492854.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001492855.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_001492858.1 COG0542 ATPases with chaperone activity, ATP-binding subunit YP_001492862.1 catalyzes the conversion of 3-hydroxyacyl-CoA to 3-oxyacyl-CoA YP_001492866.1 COG2337 Growth inhibitor YP_001492868.1 COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit YP_001492875.1 COG1286 Uncharacterized membrane protein, required for colicin V production YP_001492876.1 COG1678 Putative transcriptional regulator YP_001492877.1 COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems YP_001492880.1 COG0457 FOG: TPR repeat YP_001492883.1 COG1539 Dihydroneopterin aldolase YP_001492884.1 COG0262 Dihydrofolate reductase YP_001492885.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001492886.1 COG0500 SAM-dependent methyltransferases YP_001492888.1 COG1329 Transcriptional regulators, similar to M. xanthus CarD YP_001492889.1 COG1651 Protein-disulfide isomerase YP_001492890.1 COG5336 Uncharacterized protein conserved in bacteria YP_001492891.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001492892.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001492893.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B' is part of the membrane proton channel. YP_001492894.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_001492896.1 COG0459 Chaperonin GroEL (HSP60 family) YP_001492898.1 COG0658 Predicted membrane metal-binding protein YP_001492900.1 COG0617 tRNA nucleotidyltransferase/poly(A) polymerase YP_001492901.1 COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin YP_001492902.1 COG0802 Predicted ATPase or kinase YP_001492905.1 COG0042 tRNA-dihydrouridine synthase YP_001492906.1 COG1943 Transposase and inactivated derivatives YP_001492907.1 COG1943 Transposase and inactivated derivatives YP_001492909.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001492910.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001492911.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001492912.1 COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_001492913.1 COG0465 ATP-dependent Zn proteases YP_001492914.1 COG0270 Site-specific DNA methylase YP_001492917.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_001492918.1 COG3755 Uncharacterized protein conserved in bacteria YP_001492919.1 COG1565 Uncharacterized conserved protein YP_001492920.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001492921.1 COG0668 Small-conductance mechanosensitive channel YP_001492922.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_001492923.1 COG0558 Phosphatidylglycerophosphate synthase YP_001492926.1 COG0500 SAM-dependent methyltransferases YP_001492928.1 COG0242 N-formylmethionyl-tRNA deformylase YP_001492929.1 COG3202 ATP/ADP translocase YP_001492930.1 COG2271 Sugar phosphate permease YP_001492931.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001492932.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001492933.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001492934.1 COG1192 ATPases involved in chromosome partitioning YP_001492935.1 COG1475 Predicted transcriptional regulators YP_001492936.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001492938.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_001492940.1 COG0316 Uncharacterized conserved protein YP_001492941.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_001492942.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001492945.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001492948.1 COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases YP_001492949.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_001492950.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_001492951.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_001492952.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_001492953.1 COG3820 Uncharacterized protein conserved in bacteria YP_001492954.1 COG1282 NAD/NADP transhydrogenase beta subunit YP_001492955.1 COG3047 Outer membrane protein W YP_001492956.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_001492957.1 COG0477 Permeases of the major facilitator superfamily YP_001492961.1 COG1738 Uncharacterized conserved protein YP_001492962.1 COG1196 Chromosome segregation ATPases YP_001492964.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001492965.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001492966.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001492969.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_001492970.1 COG2121 Uncharacterized protein conserved in bacteria YP_001492971.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_001492972.1 COG0457 FOG: TPR repeat YP_001492973.1 COG2853 Surface lipoprotein YP_001492974.1 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component YP_001492975.1 COG1943 Transposase and inactivated derivatives YP_001492982.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001492983.1 COG1398 Fatty-acid desaturase YP_001492984.1 COG0462 Phosphoribosylpyrophosphate synthetase YP_001492985.1 COG0462 Phosphoribosylpyrophosphate synthetase YP_001492987.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_001492988.1 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component YP_001492989.1 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component YP_001492991.1 required for 70S ribosome assembly YP_001492992.1 RpmE; RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001492993.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001492994.1 COG3702 Type IV secretory pathway, VirB3 components YP_001492995.1 COG3451 Type IV secretory pathway, VirB4 components YP_001492996.1 COG3704 Type IV secretory pathway, VirB6 components YP_001492997.1 COG3704 Type IV secretory pathway, VirB6 components YP_001492998.1 COG3704 Type IV secretory pathway, VirB6 components YP_001492999.1 COG3704 Type IV secretory pathway, VirB6 components YP_001493000.1 COG3704 Type IV secretory pathway, VirB6 components YP_001493002.1 COG1487 Predicted nucleic acid-binding protein, contains PIN domain YP_001493003.1 catalyzes the formation of acetyl phosphate from acetyl-CoA and phosphate; can also act with other short-chain acyl-CoAs YP_001493004.1 COG0282 Acetate kinase YP_001493006.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001493007.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001493008.1 COG3750 Uncharacterized protein conserved in bacteria YP_001493009.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001493010.1 part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_001493011.1 COG0681 Signal peptidase I YP_001493012.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_001493013.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001493014.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001493015.1 COG0565 rRNA methylase YP_001493017.1 COG3660 Predicted nucleoside-diphosphate-sugar epimerase YP_001493018.1 COG0489 ATPases involved in chromosome partitioning YP_001493019.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs YP_001493021.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs YP_001493022.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_001493023.1 COG1054 Predicted sulfurtransferase YP_001493024.1 COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit YP_001493026.1 COG2142 Succinate dehydrogenase, hydrophobic anchor subunit YP_001493029.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001493030.1 COG0765 ABC-type amino acid transport system, permease component YP_001493031.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001493032.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001493033.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001493034.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001493035.1 Modulates Rho-dependent transcription termination YP_001493036.1 binds directly to 23S ribosomal RNA YP_001493037.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001493038.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001493039.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001493040.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001493041.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001493043.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001493044.1 COG1192 ATPases involved in chromosome partitioning YP_001493046.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001493048.1 COG0670 Integral membrane protein, interacts with FtsH YP_001493049.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001493050.1 COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family YP_001493051.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_001493052.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001493053.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001493054.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_001493056.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001493057.1 Catalyzes the phosphorylation of UMP to UDP YP_001493058.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001493059.1 COG0477 Permeases of the major facilitator superfamily YP_001493060.1 COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes YP_001493061.1 COG1943 Transposase and inactivated derivatives YP_001493063.1 COG4775 Outer membrane protein/protective antigen OMA87 YP_001493064.1 COG0750 Predicted membrane-associated Zn-dependent proteases 1 YP_001493065.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001493066.1 COG0293 23S rRNA methylase YP_001493070.1 COG2867 Oligoketide cyclase/lipid transport protein YP_001493072.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001493076.1 COG0776 Bacterial nucleoid DNA-binding protein YP_001493077.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001493078.1 COG0541 Signal recognition particle GTPase YP_001493079.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001493082.1 COG1301 Na+/H+-dicarboxylate symporters YP_001493083.1 COG1324 Uncharacterized protein involved in tolerance to divalent cations YP_001493084.1 COG0720 6-pyruvoyl-tetrahydropterin synthase YP_001493085.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_001493086.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001493087.1 COG2317 Zn-dependent carboxypeptidase YP_001493088.1 COG0497 ATPase involved in DNA repair YP_001493089.1 COG4105 DNA uptake lipoprotein YP_001493090.1 COG4572 Putative cation transport regulator YP_001493091.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001493092.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001493093.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_001493097.1 required for the assembly and function of the DNAX complex which are required for the assembly of the beta subunit onto primed DNA YP_001493098.1 COG2941 Ubiquinone biosynthesis protein COQ7 YP_001493100.1 COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3 YP_001493103.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_001493105.1 COG0457 FOG: TPR repeat YP_001493108.1 COG4953 Membrane carboxypeptidase/penicillin-binding protein PbpC YP_001493117.1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins YP_001493118.1 COG2358 TRAP-type uncharacterized transport system, periplasmic component YP_001493120.1 COG0633 Ferredoxin YP_001493121.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_001493122.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_001493123.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001493124.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001493125.1 COG0695 Glutaredoxin and related proteins YP_001493126.1 negatively supercoils closed circular double-stranded DNA YP_001493131.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001493132.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_001493135.1 COG1485 Predicted ATPase YP_001493136.1 COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) YP_001493137.1 COG0666 FOG: Ankyrin repeat YP_001493139.1 COG1132 ABC-type multidrug transport system, ATPase and permease components YP_001493141.1 COG1271 Cytochrome bd-type quinol oxidase, subunit 1 YP_001493142.1 COG1294 Cytochrome bd-type quinol oxidase, subunit 2 YP_001493143.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_001493144.1 COG0612 Predicted Zn-dependent peptidases YP_001493145.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001493147.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_001493153.1 COG1538 Outer membrane protein YP_001493154.1 COG3827 Uncharacterized protein conserved in bacteria YP_001493155.1 COG0666 FOG: Ankyrin repeat YP_001493156.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001493157.1 COG0793 Periplasmic protease YP_001493158.1 COG0642 Signal transduction histidine kinase YP_001493159.1 COG1729 Uncharacterized protein conserved in bacteria YP_001493160.1 COG1038 Pyruvate carboxylase YP_001493161.1 COG1520 FOG: WD40-like repeat YP_001493162.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001493163.1 forms a direct contact with the tRNA during translation YP_001493165.1 COG2154 Pterin-4a-carbinolamine dehydratase YP_001493167.1 hydrolyzes diadenosine polyphosphate YP_001493168.1 involved in swarmer-to-stalked cell differentiation in Caulobacter crescentus; catalyzes the condensation of two GTP molecules to form the secondary messenger cyclic di-GMP (c-di-GMP); upon phosphorylation of domain D1 the protein dimerizes; presumably this allows the two GTP-bound GGDEF (diguanylate cyclase) domains to catalyze the condensation reaction; allosterically inhibited by c-di-GMP YP_001493169.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001493170.1 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family YP_001493172.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine YP_001493173.1 COG1183 Phosphatidylserine synthase YP_001493174.1 COG1566 Multidrug resistance efflux pump YP_001493177.1 COG0271 Stress-induced morphogen (activity unknown) YP_001493178.1 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) YP_001493179.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001493180.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001493181.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001493182.1 COG1589 Cell division septal protein YP_001493183.1 COG0849 Actin-like ATPase involved in cell division YP_001493186.1 COG1585 Membrane protein implicated in regulation of membrane protease activity YP_001493187.1 COG3474 Cytochrome c2 YP_001493189.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_001493191.1 COG1530 Ribonucleases G and E YP_001493192.1 COG1612 Uncharacterized protein required for cytochrome oxidase assembly YP_001493193.1 COG0564 Pseudouridylate synthases, 23S RNA-specific YP_001493194.1 COG1680 Beta-lactamase class C and other penicillin binding proteins YP_001493195.1 COG0708 Exonuclease III YP_001493196.1 COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit YP_001493197.1 catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acyltransferase within the complex. The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2); it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase YP_001493198.1 COG1217 Predicted membrane GTPase involved in stress response YP_001493202.1 COG2825 Outer membrane protein YP_001493203.1 catalyzes the formation of 2-oxoglutarate from isocitrate YP_001493204.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_001493205.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001493208.1 COG0723 Rieske Fe-S protein YP_001493209.1 COG1290 Cytochrome b subunit of the bc complex YP_001493210.1 COG2857 Cytochrome c1 YP_001493212.1 COG0071 Molecular chaperone (small heat shock protein) YP_001493213.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_001493214.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001493216.1 COG3093 Plasmid maintenance system antidote protein YP_001493217.1 COG1943 Transposase and inactivated derivatives YP_001493218.1 COG0772 Bacterial cell division membrane protein YP_001493219.1 COG1770 Protease II YP_001493220.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_001493222.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_001493224.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_001493226.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001493227.1 COG3504 Type IV secretory pathway, VirB9 components YP_001493228.1 COG3736 Type IV secretory pathway, component VirB8 YP_001493230.1 COG3736 Type IV secretory pathway, component VirB8 YP_001493231.1 COG3504 Type IV secretory pathway, VirB9 components YP_001493232.1 COG2948 Type IV secretory pathway, VirB10 components YP_001493233.1 COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis YP_001493234.1 COG3505 Type IV secretory pathway, VirD4 components YP_001493235.1 COG0248 Exopolyphosphatase YP_001493242.1 COG1943 Transposase and inactivated derivatives YP_001493254.1 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase YP_001493255.1 This protein performs the mismatch recognition step during the DNA repair process YP_001493257.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_001493258.1 COG0739 Membrane proteins related to metalloendopeptidases YP_001493259.1 COG2161 Antitoxin of toxin-antitoxin stability system YP_001493260.1 COG4115 Uncharacterized protein conserved in bacteria YP_001493261.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor YP_001493262.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_001493263.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_001493264.1 involved in the insertion of copper into subunit I of cytochrome C oxidase YP_001493266.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001493267.1 COG0531 Amino acid transporters YP_001493268.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001493269.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains YP_001493270.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains YP_001493271.1 COG0811 Biopolymer transport proteins YP_001493272.1 COG0848 Biopolymer transport protein YP_001493274.1 COG1266 Predicted metal-dependent membrane protease YP_001493275.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_001493276.1 COG0477 Permeases of the major facilitator superfamily YP_001493277.1 COG0845 Membrane-fusion protein YP_001493278.1 COG4618 ABC-type protease/lipase transport system, ATPase and permease components YP_001493279.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001493280.1 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases YP_001493282.1 heat shock protein involved in degradation of misfolded proteins YP_001493283.1 heat shock protein involved in degradation of misfolded proteins YP_001493285.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_001493287.1 COG1559 Predicted periplasmic solute-binding protein YP_001493288.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_001493294.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001493295.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001493298.1 COG0450 Peroxiredoxin YP_001493299.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs YP_001493300.1 COG2194 Predicted membrane-associated, metal-dependent hydrolase YP_001493301.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001493302.1 COG3093 Plasmid maintenance system antidote protein YP_001493303.1 COG1091 dTDP-4-dehydrorhamnose reductase YP_001493304.1 COG1086 Predicted nucleoside-diphosphate sugar epimerases YP_001493305.1 COG0381 UDP-N-acetylglucosamine 2-epimerase YP_001493309.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_001493311.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_001493312.1 COG0438 Glycosyltransferase YP_001493313.1 COG1132 ABC-type multidrug transport system, ATPase and permease components YP_001493314.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains YP_001493318.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001493319.1 converts protoheme IX and farnesyl diphosphate to heme O YP_001493320.1 COG1533 DNA repair photolyase YP_001493325.1 COG2982 Uncharacterized protein involved in outer membrane biogenesis YP_001493327.1 Essential for efficient processing of 16S rRNA YP_001493328.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_001493330.1 COG2094 3-methyladenine DNA glycosylase YP_001493331.1 COG0759 Uncharacterized conserved protein YP_001493332.1 Catalyzes the transfer of electrons from NADH to quinone YP_001493333.1 Catalyzes the transfer of electrons from NADH to quinone YP_001493334.1 COG2827 Predicted endonuclease containing a URI domain YP_001493335.1 COG2827 Predicted endonuclease containing a URI domain YP_001493336.1 Catalyzes the transfer of electrons from NADH to quinone YP_001493337.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_001493338.1 Catalyzes the transfer of electrons from NADH to quinone YP_001493339.1 COG3307 Lipid A core - O-antigen ligase and related enzymes YP_001493340.1 COG4765 Uncharacterized protein conserved in bacteria YP_001493341.1 COG5410 Uncharacterized protein conserved in bacteria YP_001493344.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001493347.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001493348.1 Transfers the fatty acyl group on membrane lipoproteins YP_001493349.1 COG2984 ABC-type uncharacterized transport system, periplasmic component YP_001493350.1 COG4120 ABC-type uncharacterized transport system, permease component YP_001493351.1 COG1101 ABC-type uncharacterized transport system, ATPase component YP_001493353.1 COG1495 Disulfide bond formation protein DsbB YP_001493354.1 class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine YP_001493355.1 COG0679 Predicted permeases YP_001493356.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_001493357.1 COG5307 SEC7 domain proteins YP_001493358.1 COG1943 Transposase and inactivated derivatives YP_001493359.1 COG4374 Uncharacterized protein conserved in bacteria YP_001493362.1 COG0477 Permeases of the major facilitator superfamily YP_001493365.1 Catalyzes the reversible oxidation of malate to oxaloacetate YP_001493366.1 COG3202 ATP/ADP translocase YP_001493369.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_001493370.1 COG1051 ADP-ribose pyrophosphatase YP_001493372.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001493373.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001493377.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001493380.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001493381.1 COG1132 ABC-type multidrug transport system, ATPase and permease components YP_001493382.1 COG0477 Permeases of the major facilitator superfamily YP_001493383.1 COG1686 D-alanyl-D-alanine carboxypeptidase YP_001493384.1 COG0797 Lipoproteins YP_001493385.1 COG2823 Predicted periplasmic or secreted lipoprotein YP_001493386.1 Involved in cell division; probably involved in intracellular septation YP_001493387.1 COG0672 High-affinity Fe2+/Pb2+ permease YP_001493390.1 COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2 YP_001493391.1 COG3485 Protocatechuate 3,4-dioxygenase beta subunit YP_001493392.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_001493393.1 COG0616 Periplasmic serine proteases (ClpP class) YP_001493394.1 catalyzes the formation of dUMP from dUTP YP_001493395.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_001493397.1 COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF YP_001493398.1 COG2887 RecB family exonuclease YP_001493400.1 COG2071 Predicted glutamine amidotransferases YP_001493401.1 COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1 YP_001493404.1 COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2 YP_001493405.1 COG0739 Membrane proteins related to metalloendopeptidases YP_001493406.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001493408.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001493409.1 COG0772 Bacterial cell division membrane protein YP_001493410.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001493413.1 COG0841 Cation/multidrug efflux pump YP_001493415.1 COG0845 Membrane-fusion protein YP_001493416.1 COG0845 Membrane-fusion protein YP_001493417.1 COG1538 Outer membrane protein YP_001493418.1 COG0438 Glycosyltransferase YP_001493420.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001493421.1 COG0621 2-methylthioadenine synthetase YP_001493422.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001493423.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001493424.1 binds the polymerase to DNA and acts as a sliding clamp YP_001493426.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001493427.1 COG0349 Ribonuclease D YP_001493428.1 COG2919 Septum formation initiator YP_001493429.1 COG0575 CDP-diglyceride synthetase YP_001493430.1 COG0020 Undecaprenyl pyrophosphate synthase YP_001493431.1 COG0642 Signal transduction histidine kinase YP_001493432.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_001493433.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001493434.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001493435.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001493436.1 COG1651 Protein-disulfide isomerase YP_001493437.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_001493438.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001493440.1 COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases YP_001493441.1 COG4395 Uncharacterized protein conserved in bacteria YP_001493442.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001493443.1 COG1238 Predicted membrane protein YP_001493444.1 COG1714 Predicted membrane protein/domain YP_001493445.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001493446.1 COG3023 Negative regulator of beta-lactamase expression YP_001493453.1 catalyzes the phosphorylation of NAD to NADP YP_001493454.1 COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily YP_001493456.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001493459.1 COG0679 Predicted permeases YP_001493460.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_001493461.1 COG0492 Thioredoxin reductase YP_001493465.1 COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain YP_001493467.1 COG1943 Transposase and inactivated derivatives YP_001493468.1 COG1012 NAD-dependent aldehyde dehydrogenases YP_001493470.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_001493471.1 COG0210 Superfamily I DNA and RNA helicases YP_001493476.1 catalyzes the formation of 2-oxobutanoate from L-threonine YP_001493477.1 COG0466 ATP-dependent Lon protease, bacterial type YP_001493481.1 COG1544 Ribosome-associated protein Y (PSrp-1) YP_001493482.1 COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily YP_001493483.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001493485.1 COG0492 Thioredoxin reductase YP_001493488.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001493489.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_001493490.1 COG1357 Uncharacterized low-complexity proteins YP_001493492.1 COG1943 Transposase and inactivated derivatives YP_001493495.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001493496.1 COG1109 Phosphomannomutase YP_001493497.1 COG1137 ABC-type (unclassified) transport system, ATPase component YP_001493498.1 COG1934 Uncharacterized protein conserved in bacteria YP_001493499.1 COG5375 Uncharacterized protein conserved in bacteria YP_001493500.1 COG0794 Predicted sugar phosphate isomerase involved in capsule formation YP_001493501.1 COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) YP_001493502.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001493503.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001493504.1 COG3202 ATP/ADP translocase YP_001493507.1 COG1943 Transposase and inactivated derivatives YP_001493508.1 COG1396 Predicted transcriptional regulators YP_001493509.1 COG1295 Predicted membrane protein YP_001493510.1 COG0174 Glutamine synthetase YP_001493511.1 COG1496 Uncharacterized conserved protein YP_001493512.1 COG0242 N-formylmethionyl-tRNA deformylase YP_001493517.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001493518.1 COG0625 Glutathione S-transferase YP_001493519.1 COG4285 Uncharacterized conserved protein YP_001493521.1 COG1268 Uncharacterized conserved protein YP_001493522.1 COG0285 Folylpolyglutamate synthase YP_001493523.1 COG0605 Superoxide dismutase YP_001493525.1 COG0340 Biotin-(acetyl-CoA carboxylase) ligase YP_001493530.1 COG5448 Uncharacterized conserved protein YP_001493532.1 COG5449 Uncharacterized conserved protein YP_001493534.1 COG5346 Predicted membrane protein YP_001493535.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_001493536.1 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes YP_001493537.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001493538.1 COG0608 Single-stranded DNA-specific exonuclease YP_001493539.1 COG0500 SAM-dependent methyltransferases YP_001493540.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001493541.1 COG0776 Bacterial nucleoid DNA-binding protein YP_001493544.1 COG3022 Uncharacterized protein conserved in bacteria YP_001493545.1 COG0642 Signal transduction histidine kinase YP_001493548.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_001493549.1 COG0142 Geranylgeranyl pyrophosphate synthase YP_001493551.1 COG3202 ATP/ADP translocase YP_001493552.1 COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases YP_001493553.1 COG0477 Permeases of the major facilitator superfamily YP_001493556.1 COG0457 FOG: TPR repeat YP_001493557.1 COG2945 Predicted hydrolase of the alpha/beta superfamily YP_001493558.1 COG3077 DNA-damage-inducible protein J YP_001493559.1 COG3041 Uncharacterized protein conserved in bacteria YP_001493560.1 COG5622 Protein required for attachment to host cells YP_001493561.1 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_001493562.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001493564.1 COG0006 Xaa-Pro aminopeptidase YP_001493565.1 COG0531 Amino acid transporters YP_001493571.1 COG0316 Uncharacterized conserved protein YP_001493572.1 COG0822 NifU homolog involved in Fe-S cluster formation YP_001493573.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_001493574.1 COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes YP_001493575.1 COG1959 Predicted transcriptional regulator YP_001493578.1 Catalyzes the transfer of electrons from NADH to quinone YP_001493580.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001493581.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_001493582.1 COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase YP_001493583.1 unwinds double stranded DNA YP_001493585.1 COG0814 Amino acid permeases YP_001493586.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_001493587.1 COG1357 Uncharacterized low-complexity proteins YP_001493588.1 COG0742 N6-adenine-specific methylase YP_001493589.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001493590.1 COG0191 Fructose/tagatose bisphosphate aldolase YP_001493591.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_001493592.1 COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone YP_001493593.1 COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain) YP_001493594.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001493595.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001493596.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001493597.1 COG3177 Uncharacterized conserved protein YP_001493599.1 COG1189 Predicted rRNA methylase YP_001493600.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001493604.1 COG0354 Predicted aminomethyltransferase related to GcvT YP_001493605.1 COG1723 Uncharacterized conserved protein YP_001493606.1 COG0349 Ribonuclease D YP_001493607.1 COG0212 5-formyltetrahydrofolate cyclo-ligase YP_001493608.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001493609.1 COG0500 SAM-dependent methyltransferases YP_001493612.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_001493615.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif YP_001493616.1 COG0217 Uncharacterized conserved protein YP_001493617.1 COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) YP_001493619.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate YP_001493626.1 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins YP_001493627.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001493628.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001493629.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001493632.1 COG1301 Na+/H+-dicarboxylate symporters YP_001493641.1 COG3328 Transposase and inactivated derivatives YP_001493642.1 COG3328 Transposase and inactivated derivatives YP_001493643.1 COG1943 Transposase and inactivated derivatives YP_001493644.1 COG2373 Large extracellular alpha-helical protein YP_001493645.1 COG1250 3-hydroxyacyl-CoA dehydrogenase YP_001493647.1 COG0474 Cation transport ATPase YP_001493650.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone YP_001493651.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001493652.1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains YP_001493653.1 COG1357 Uncharacterized low-complexity proteins YP_001493656.1 COG0666 FOG: Ankyrin repeat YP_001493657.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2 YP_001493659.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2 YP_001493661.1 COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis YP_001493662.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001493663.1 COG0591 Na+/proline symporter YP_001493664.1 COG2161 Antitoxin of toxin-antitoxin stability system YP_001493666.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001493667.1 COG2847 Uncharacterized protein conserved in bacteria YP_001493668.1 COG4912 Predicted DNA alkylation repair enzyme YP_001493673.1 COG0666 FOG: Ankyrin repeat YP_001493675.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001493676.1 COG0760 Parvulin-like peptidyl-prolyl isomerase YP_001493677.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001493678.1 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_001493679.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001493680.1 negatively supercoils closed circular double-stranded DNA YP_001493681.1 COG0647 Predicted sugar phosphatases of the HAD superfamily YP_001493682.1 COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain) YP_001493686.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_001493687.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001493688.1 COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems YP_001493689.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_001493690.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_001493691.1 COG0728 Uncharacterized membrane protein, putative virulence factor YP_001493694.1 COG1200 RecG-like helicase YP_001493697.1 COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit YP_001493699.1 COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit YP_001493702.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001493703.1 COG0770 UDP-N-acetylmuramyl pentapeptide synthase YP_001493704.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001493705.1 COG1197 Transcription-repair coupling factor (superfamily II helicase) YP_001493706.1 COG2938 Uncharacterized conserved protein YP_001493707.1 COG0607 Rhodanese-related sulfurtransferase YP_001493708.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001493712.1 COG3621 Patatin YP_001493713.1 COG0477 Permeases of the major facilitator superfamily YP_001493714.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001493717.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001493718.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001493719.1 COG0602 Organic radical activating enzymes YP_001493721.1 COG0291 Ribosomal protein L35 YP_001493722.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001493723.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_001493724.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_001493729.1 COG3173 Predicted aminoglycoside phosphotransferase YP_001493730.1 COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation YP_001493731.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001493732.1 COG5590 Uncharacterized conserved protein YP_001493733.1 COG1848 Predicted nucleic acid-binding protein, contains PIN domain YP_001493734.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) YP_001493737.1 COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit YP_001493738.1 COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) YP_001493741.1 Synthesizes thioester adducts of fatty acids enzymatically to the phosphopantetheine group of acyl carrier protein YP_001493742.1 COG3070 Regulator of competence-specific genes YP_001493743.1 COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components YP_001493744.1 Involved in ubiquinone biosynthesis YP_001493745.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001493746.1 COG5342 Invasion protein B, involved in pathogenesis YP_001493748.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_001493749.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001493750.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001493752.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001493753.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_001493754.1 COG0628 Predicted permease YP_001493755.1 COG0593 ATPase involved in DNA replication initiation YP_001493756.1 COG0477 Permeases of the major facilitator superfamily YP_001493757.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001493758.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001493759.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001493760.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001493761.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001493762.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001493763.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001493764.1 late assembly protein YP_001493765.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001493766.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001493767.1 binds 5S rRNA along with protein L5 and L25 YP_001493768.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001493769.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001493770.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001493771.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001493772.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001493773.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001493774.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001493775.1 one of the stabilizing components for the large ribosomal subunit YP_001493776.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001493777.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001493778.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001493779.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001493780.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001493781.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001493782.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001493783.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001493784.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_001493785.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001493786.1 COG0566 rRNA methylases YP_001493788.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001493789.1 COG4118 Antitoxin of toxin-antitoxin stability system YP_001493791.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001493793.1 COG4574 Serine protease inhibitor ecotin YP_001493794.1 COG0694 Thioredoxin-like proteins and domains YP_001493795.1 COG0477 Permeases of the major facilitator superfamily YP_001493797.1 COG0513 Superfamily II DNA and RNA helicases YP_001493798.1 COG1278 Cold shock proteins YP_001493800.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001493801.1 COG0760 Parvulin-like peptidyl-prolyl isomerase YP_001493802.1 COG1452 Organic solvent tolerance protein OstA YP_001493804.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001493805.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_001493806.1 COG0708 Exonuclease III YP_001493807.1 COG4095 Uncharacterized conserved protein YP_001493808.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001493809.1 COG1373 Predicted ATPase (AAA+ superfamily) YP_001493812.1 COG0661 Predicted unusual protein kinase YP_001493813.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_001493816.1 COG0836 Mannose-1-phosphate guanylyltransferase YP_001493817.1 COG0836 Mannose-1-phosphate guanylyltransferase YP_001493819.1 COG4553 Poly-beta-hydroxyalkanoate depolymerase YP_001493821.1 COG0084 Mg-dependent DNase YP_001493822.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001493823.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_001493824.1 COG0477 Permeases of the major facilitator superfamily YP_001493825.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin YP_001493826.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001493827.1 COG1322 Uncharacterized protein conserved in bacteria YP_001493834.1 binds and unfolds substrates as part of the ClpXP protease YP_001493835.1 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins YP_001493836.1 COG0603 Predicted PP-loop superfamily ATPase YP_001493838.1 COG1598 Uncharacterized conserved protein YP_001493840.1 COG1132 ABC-type multidrug transport system, ATPase and permease components YP_001493842.1 COG0477 Permeases of the major facilitator superfamily YP_001493843.1 COG4591 ABC-type transport system, involved in lipoprotein release, permease component YP_001493844.1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component YP_001493847.1 COG4536 Putative Mg2+ and Co2+ transporter CorB YP_001493848.1 COG1138 Cytochrome c biogenesis factor YP_001493850.1 COG4625 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain YP_001493851.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_001493852.1 COG1472 Beta-glucosidase-related glycosidases YP_001493853.1 COG0789 Predicted transcriptional regulators YP_001493854.1 COG0776 Bacterial nucleoid DNA-binding protein YP_001493856.1 COG1225 Peroxiredoxin YP_001493857.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_001493858.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_001493859.1 COG0739 Membrane proteins related to metalloendopeptidases YP_001493860.1 COG2961 Protein involved in catabolism of external DNA YP_001493862.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_001493864.1 COG2161 Antitoxin of toxin-antitoxin stability system YP_001493865.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001493869.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001493870.1 COG2902 NAD-specific glutamate dehydrogenase YP_001493872.1 COG3027 Uncharacterized protein conserved in bacteria YP_001493874.1 COG0477 Permeases of the major facilitator superfamily YP_001493877.1 COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold YP_001493878.1 COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold YP_001493879.1 COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains YP_001493880.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_001493881.1 involved in the peptidyltransferase reaction during translation YP_001493882.1 COG0261 Ribosomal protein L21 YP_001493883.1 COG1267 Phosphatidylglycerophosphatase A and related proteins YP_001493884.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001493886.1 COG0313 Predicted methyltransferases YP_001493889.1 COG5510 Predicted small secreted protein YP_001493890.1 COG0177 Predicted EndoIII-related endonuclease YP_001493891.1 COG0278 Glutaredoxin-related protein YP_001493892.1 COG0400 Predicted esterase YP_001493895.1 COG0863 DNA modification methylase YP_001493897.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001493898.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001493900.1 COG2337 Growth inhibitor YP_001493901.1 COG0319 Predicted metal-dependent hydrolase YP_001493902.1 COG1253 Hemolysins and related proteins containing CBS domains YP_001493904.1 COG1943 Transposase and inactivated derivatives YP_001493905.1 COG3202 ATP/ADP translocase YP_001493906.1 COG3243 Poly(3-hydroxyalkanoate) synthetase YP_001493907.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001493912.1 COG0331 (acyl-carrier-protein) S-malonyltransferase YP_001493913.1 COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) YP_001493914.1 COG3346 Uncharacterized conserved protein YP_001493915.1 3'-5' exonuclease of DNA polymerase III YP_001493916.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_001493917.1 COG3494 Uncharacterized protein conserved in bacteria YP_001493918.1 COG3814 Uncharacterized protein conserved in bacteria YP_001493919.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_001493920.1 COG3761 NADH:ubiquinone oxidoreductase 17.2 kD subunit YP_001493921.1 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component YP_001493923.1 COG0477 Permeases of the major facilitator superfamily YP_001493924.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_001493927.1 COG0477 Permeases of the major facilitator superfamily YP_001493928.1 COG0477 Permeases of the major facilitator superfamily YP_001493929.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001493930.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001493931.1 carries the fatty acid chain in fatty acid biosynthesis YP_001493932.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001493935.1 COG1373 Predicted ATPase (AAA+ superfamily) YP_001493936.1 COG1373 Predicted ATPase (AAA+ superfamily) YP_001493937.1 COG1373 Predicted ATPase (AAA+ superfamily) YP_001493938.1 Essential for recycling GMP and indirectly, cGMP YP_001493939.1 COG1396 Predicted transcriptional regulators YP_001493940.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001493941.1 functions in MreBCD complex in some organisms YP_001493942.1 COG0795 Predicted permeases YP_001493943.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_001493944.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001493945.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001493946.1 COG2913 Small protein A (tmRNA-binding) YP_001493947.1 COG0552 Signal recognition particle GTPase YP_001493948.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_001493949.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001493951.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_001493952.1 COG1004 Predicted UDP-glucose 6-dehydrogenase YP_001493954.1 COG0477 Permeases of the major facilitator superfamily YP_001493955.1 COG0805 Sec-independent protein secretion pathway component TatC YP_001493956.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001493957.1 COG3451 Type IV secretory pathway, VirB4 components YP_001493959.1 COG0861 Membrane protein TerC, possibly involved in tellurium resistance YP_001493960.1 COG3637 Opacity protein and related surface antigens YP_001493961.1 COG0500 SAM-dependent methyltransferases YP_001493962.1 Catalyzes the transfer of electrons from NADH to quinone YP_001493963.1 Catalyzes the transfer of electrons from NADH to quinone YP_001493964.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_001493965.1 Catalyzes the transfer of electrons from NADH to quinone YP_001493967.1 ATP-binding protein; required for proper cytochrome c maturation YP_001493968.1 Catalyzes the transfer of electrons from NADH to quinone YP_001493969.1 COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) YP_001493970.1 Catalyzes the transfer of electrons from NADH to quinone YP_001493971.1 Catalyzes the transfer of electrons from NADH to quinone YP_001493972.1 COG3671 Predicted membrane protein YP_001493975.1 Catalyzes the conversion of citrate to isocitrate YP_001493976.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_001493977.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001493978.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001493979.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001493980.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001493981.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001493982.1 COG0783 DNA-binding ferritin-like protein (oxidative damage protectant) YP_001493985.1 COG5009 Membrane carboxypeptidase/penicillin-binding protein YP_001493986.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001493989.1 COG3807 Uncharacterized protein conserved in bacteria YP_001493990.1 COG0475 Kef-type K+ transport systems, membrane components YP_001493991.1 COG0799 Uncharacterized homolog of plant Iojap protein YP_001493992.1 COG0271 Stress-induced morphogen (activity unknown) YP_001493994.1 COG1396 Predicted transcriptional regulators YP_001493995.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001493996.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001493997.1 COG1734 DnaK suppressor protein YP_001493998.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001494000.1 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes YP_001494001.1 COG3243 Poly(3-hydroxyalkanoate) synthetase YP_001494002.1 COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases YP_001494003.1 COG0760 Parvulin-like peptidyl-prolyl isomerase YP_001494011.1 COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins YP_001494012.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_001494013.1 COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase YP_001494015.1 COG3637 Opacity protein and related surface antigens YP_001494016.1 COG3637 Opacity protein and related surface antigens YP_001494017.1 COG1146 Ferredoxin YP_001494018.1 COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component YP_001494019.1 COG0590 Cytosine/adenosine deaminases YP_001494020.1 COG0053 Predicted Co/Zn/Cd cation transporters YP_001494021.1 COG4520 Surface antigen YP_001494022.1 COG1881 Phospholipid-binding protein YP_001494023.1 COG1121 ABC-type Mn/Zn transport systems, ATPase component YP_001494024.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001494025.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_001494027.1 COG0477 Permeases of the major facilitator superfamily YP_001494033.1 COG1872 Uncharacterized conserved protein YP_001494034.1 molecular chaperone YP_001494035.1 catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine YP_001494037.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001494038.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001494039.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_001494041.1 COG1573 Uracil-DNA glycosylase YP_001494042.1 COG0564 Pseudouridylate synthases, 23S RNA-specific YP_001494044.1 COG2337 Growth inhibitor YP_001494045.1 fusion of hemK/trmB; N-terminal HemK domain transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; C-terminal YP_001494046.1 COG0009 Putative translation factor (SUA5) YP_001494047.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001494048.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001494049.1 COG1487 Predicted nucleic acid-binding protein, contains PIN domain YP_001494050.1 COG1636 Uncharacterized protein conserved in bacteria YP_001494051.1 COG0477 Permeases of the major facilitator superfamily YP_001494052.1 COG0477 Permeases of the major facilitator superfamily YP_001494054.1 COG1474 Cdc6-related protein, AAA superfamily ATPase YP_001494056.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001494063.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001494064.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_001494065.1 synthesizes RNA primers at the replication forks YP_001494066.1 COG0170 Dolichol kinase YP_001494067.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001494068.1 COG3288 NAD/NADP transhydrogenase alpha subunit YP_001494069.1 COG3288 NAD/NADP transhydrogenase alpha subunit YP_001494070.1 COG2834 Outer membrane lipoprotein-sorting protein YP_001494071.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; rhe tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_001494072.1 COG0718 Uncharacterized protein conserved in bacteria YP_001494073.1 COG3577 Predicted aspartyl protease YP_001494074.1 COG1680 Beta-lactamase class C and other penicillin binding proteins YP_001494075.1 COG1126 ABC-type polar amino acid transport system, ATPase component YP_001494076.1 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I YP_001494077.1 COG0671 Membrane-associated phospholipid phosphatase YP_001494078.1 COG0795 Predicted permeases YP_001494079.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001494081.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001494082.1 COG0286 Type I restriction-modification system methyltransferase subunit YP_001494085.1 COG3004 Na+/H+ antiporter YP_001494086.1 COG3004 Na+/H+ antiporter YP_001494087.1 COG1434 Uncharacterized conserved protein YP_001494088.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_001494089.1 COG3023 Negative regulator of beta-lactamase expression YP_001494090.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001494091.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001494092.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001494093.1 COG4391 Uncharacterized protein conserved in bacteria YP_001494095.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_001494099.1 COG0477 Permeases of the major facilitator superfamily YP_001494100.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_001494102.1 COG1981 Predicted membrane protein YP_001494103.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_001494104.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III