-- dump date 20140620_033339 -- class Genbank::misc_feature -- table misc_feature_note -- id note 293614000001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 293614000002 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 293614000003 catalytic residues [active] 293614000004 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 293614000005 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 293614000006 Walker A/P-loop; other site 293614000007 ATP binding site [chemical binding]; other site 293614000008 Q-loop/lid; other site 293614000009 ABC transporter signature motif; other site 293614000010 Walker B; other site 293614000011 D-loop; other site 293614000012 H-loop/switch region; other site 293614000013 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 293614000014 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 293614000015 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 293614000016 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 293614000017 FAD binding pocket [chemical binding]; other site 293614000018 FAD binding motif [chemical binding]; other site 293614000019 phosphate binding motif [ion binding]; other site 293614000020 beta-alpha-beta structure motif; other site 293614000021 NAD binding pocket [chemical binding]; other site 293614000022 Iron coordination center [ion binding]; other site 293614000023 acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Region: lipid_A_lpxA; TIGR01852 293614000024 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 293614000025 active site 293614000026 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 293614000027 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 293614000028 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 293614000029 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 293614000030 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 293614000031 trimer interface [polypeptide binding]; other site 293614000032 active site 293614000033 UDP-GlcNAc binding site [chemical binding]; other site 293614000034 lipid binding site [chemical binding]; lipid-binding site 293614000035 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 293614000036 active site 293614000037 nucleophile elbow; other site 293614000038 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 293614000039 Clp amino terminal domain; Region: Clp_N; pfam02861 293614000040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 293614000041 Walker A motif; other site 293614000042 ATP binding site [chemical binding]; other site 293614000043 Walker B motif; other site 293614000044 arginine finger; other site 293614000045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 293614000046 Walker A motif; other site 293614000047 ATP binding site [chemical binding]; other site 293614000048 Walker B motif; other site 293614000049 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 293614000050 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 293614000051 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 293614000052 NAD(P) binding site [chemical binding]; other site 293614000053 homotetramer interface [polypeptide binding]; other site 293614000054 homodimer interface [polypeptide binding]; other site 293614000055 active site 293614000056 Protein of unknown function (DUF2748); Region: DUF2748; pfam10871 293614000057 PemK-like protein; Region: PemK; cl00995 293614000058 Autotransporter beta-domain; Region: Autotransporter; smart00869 293614000059 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 293614000060 Colicin V production protein; Region: Colicin_V; pfam02674 293614000061 Putative transcriptional regulator [Transcription]; Region: COG1678 293614000062 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 293614000063 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 293614000064 Cu(I) binding site [ion binding]; other site 293614000065 tetratricopeptide repeat protein; Provisional; Region: PRK11788 293614000066 Dihydroneopterin aldolase; Region: FolB; smart00905 293614000067 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 293614000068 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 293614000069 dimer interface [polypeptide binding]; other site 293614000070 inhibitor binding site; inhibition site 293614000071 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 293614000072 recombination protein F; Reviewed; Region: recF; PRK00064 293614000073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 293614000074 Walker A/P-loop; other site 293614000075 ATP binding site [chemical binding]; other site 293614000076 Q-loop/lid; other site 293614000077 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 293614000078 ABC transporter signature motif; other site 293614000079 Walker B; other site 293614000080 D-loop; other site 293614000081 H-loop/switch region; other site 293614000082 Methyltransferase domain; Region: Methyltransf_31; pfam13847 293614000083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 293614000084 S-adenosylmethionine binding site [chemical binding]; other site 293614000085 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 293614000086 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 293614000087 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 293614000088 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 293614000089 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 293614000090 catalytic residues [active] 293614000091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 293614000092 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 293614000093 ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Region: ATP_synt_6_or_A; TIGR01131 293614000094 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 293614000095 F0F1 ATP synthase subunit B'; Validated; Region: PRK06569 293614000096 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 293614000097 F0F1 ATP synthase subunit B; Validated; Region: PRK06568 293614000098 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 293614000099 Autotransporter beta-domain; Region: Autotransporter; pfam03797 293614000100 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 293614000101 Competence protein; Region: Competence; pfam03772 293614000102 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 293614000103 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 293614000104 active site 293614000105 NTP binding site [chemical binding]; other site 293614000106 metal binding triad [ion binding]; metal-binding site 293614000107 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 293614000108 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 293614000109 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 293614000110 intersubunit interface [polypeptide binding]; other site 293614000111 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 293614000112 Putative catalytic NodB homology domain of uncharacterized protein RC0012 from Rickettsia conorii and its bacterial homologs; Region: CE4_RC0012_like; cd10963 293614000113 NodB motif; other site 293614000114 putative active site [active] 293614000115 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 293614000116 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 293614000117 FMN binding site [chemical binding]; other site 293614000118 active site 293614000119 catalytic residues [active] 293614000120 substrate binding site [chemical binding]; other site 293614000121 Transposase IS200 like; Region: Y1_Tnp; pfam01797 293614000122 Transposase IS200 like; Region: Y1_Tnp; cl00848 293614000123 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 293614000124 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 293614000125 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 293614000126 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 293614000127 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 293614000128 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 293614000129 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 293614000130 Ligand Binding Site [chemical binding]; other site 293614000131 FtsH Extracellular; Region: FtsH_ext; pfam06480 293614000132 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 293614000133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 293614000134 Walker A motif; other site 293614000135 ATP binding site [chemical binding]; other site 293614000136 Walker B motif; other site 293614000137 arginine finger; other site 293614000138 Peptidase family M41; Region: Peptidase_M41; pfam01434 293614000139 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 293614000140 cofactor binding site; other site 293614000141 DNA binding site [nucleotide binding] 293614000142 substrate interaction site [chemical binding]; other site 293614000143 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 293614000144 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 293614000145 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 293614000146 Uncharacterized conserved protein [Function unknown]; Region: COG1565 293614000147 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 293614000148 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 293614000149 Mechanosensitive ion channel; Region: MS_channel; pfam00924 293614000150 membrane protein insertase; Provisional; Region: PRK01318 293614000151 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 293614000152 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 293614000153 Methyltransferase domain; Region: Methyltransf_11; pfam08241 293614000154 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234 293614000155 active site 293614000156 metal binding site [ion binding]; metal-binding site 293614000157 catalytic residues [active] 293614000158 TLC ATP/ADP transporter; Region: TLC; pfam03219 293614000159 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 293614000160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 293614000161 putative substrate translocation pore; other site 293614000162 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 293614000163 active site 293614000164 multimer interface [polypeptide binding]; other site 293614000165 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 293614000166 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 293614000167 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 293614000168 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 293614000169 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 293614000170 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 293614000171 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 293614000172 P-loop; other site 293614000173 Magnesium ion binding site [ion binding]; other site 293614000174 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 293614000175 Magnesium ion binding site [ion binding]; other site 293614000176 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 293614000177 ParB-like nuclease domain; Region: ParB; smart00470 293614000178 KorB domain; Region: KorB; pfam08535 293614000179 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 293614000180 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 293614000181 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 293614000182 ABC transporter; Region: ABC_tran_2; pfam12848 293614000183 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 293614000184 Protein of unknown function (DUF2672); Region: DUF2672; pfam10878 293614000185 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 293614000186 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 293614000187 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 293614000188 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 293614000189 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 293614000190 Zn2+ binding site [ion binding]; other site 293614000191 Mg2+ binding site [ion binding]; other site 293614000192 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 293614000193 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 293614000194 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 293614000195 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 293614000196 active site 293614000197 HIGH motif; other site 293614000198 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 293614000199 KMSK motif region; other site 293614000200 tRNA binding surface [nucleotide binding]; other site 293614000201 DALR anticodon binding domain; Region: DALR_1; smart00836 293614000202 anticodon binding site; other site 293614000203 Sporulation related domain; Region: SPOR; pfam05036 293614000204 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 293614000205 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 293614000206 CAP-like domain; other site 293614000207 active site 293614000208 primary dimer interface [polypeptide binding]; other site 293614000209 Gram-negative porin; Region: Porin_4; pfam13609 293614000210 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 293614000211 trimer interface [polypeptide binding]; other site 293614000212 active site 293614000213 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 293614000214 SecA binding site; other site 293614000215 Preprotein binding site; other site 293614000216 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 293614000217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 293614000218 active site 293614000219 phosphorylation site [posttranslational modification] 293614000220 intermolecular recognition site; other site 293614000221 dimerization interface [polypeptide binding]; other site 293614000222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 293614000223 DNA binding site [nucleotide binding] 293614000224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 293614000225 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 293614000226 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 293614000227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 293614000228 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 293614000229 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 293614000230 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 293614000231 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 293614000232 EamA-like transporter family; Region: EamA; pfam00892 293614000233 EamA-like transporter family; Region: EamA; pfam00892 293614000234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 293614000235 metabolite-proton symporter; Region: 2A0106; TIGR00883 293614000236 putative substrate translocation pore; other site 293614000237 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 293614000238 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 293614000239 Tumour suppressor, Mitostatin; Region: Trichoplein; pfam13868 293614000240 Tumour suppressor, Mitostatin; Region: Trichoplein; pfam13868 293614000241 Autotransporter beta-domain; Region: Autotransporter; pfam03797 293614000242 Autotransporter beta-domain; Region: Autotransporter; pfam03797 293614000243 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 293614000244 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 293614000245 active site 293614000246 HIGH motif; other site 293614000247 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 293614000248 KMSKS motif; other site 293614000249 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 293614000250 tRNA binding surface [nucleotide binding]; other site 293614000251 anticodon binding site; other site 293614000252 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 293614000253 rRNA interaction site [nucleotide binding]; other site 293614000254 S8 interaction site; other site 293614000255 putative laminin-1 binding site; other site 293614000256 elongation factor Ts; Provisional; Region: tsf; PRK09377 293614000257 UBA/TS-N domain; Region: UBA; pfam00627 293614000258 Elongation factor TS; Region: EF_TS; pfam00889 293614000259 Elongation factor TS; Region: EF_TS; pfam00889 293614000260 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 293614000261 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 293614000262 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 293614000263 putative acyl-acceptor binding pocket; other site 293614000264 aspartate aminotransferase; Provisional; Region: PRK05764 293614000265 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 293614000266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 293614000267 homodimer interface [polypeptide binding]; other site 293614000268 catalytic residue [active] 293614000269 TPR repeat; Region: TPR_11; pfam13414 293614000270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 293614000271 binding surface 293614000272 TPR motif; other site 293614000273 Methyltransferase domain; Region: Methyltransf_23; pfam13489 293614000274 Methyltransferase domain; Region: Methyltransf_18; pfam12847 293614000275 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 293614000276 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854 293614000277 Transposase IS200 like; Region: Y1_Tnp; cl00848 293614000278 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 293614000279 UGMP family protein; Validated; Region: PRK09604 293614000280 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 293614000281 Rickettsial palindromic element RPE3 domain; Region: RPE3; TIGR03775 293614000282 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 293614000283 Fatty acid desaturase; Region: FA_desaturase; pfam00487 293614000284 Di-iron ligands [ion binding]; other site 293614000285 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 293614000286 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 293614000287 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 293614000288 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 293614000289 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 293614000290 active site 293614000291 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 293614000292 dimer interface [polypeptide binding]; other site 293614000293 substrate binding site [chemical binding]; other site 293614000294 catalytic residues [active] 293614000295 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 293614000296 Permease; Region: Permease; pfam02405 293614000297 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 293614000298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 293614000299 Walker A/P-loop; other site 293614000300 ATP binding site [chemical binding]; other site 293614000301 Q-loop/lid; other site 293614000302 ABC transporter signature motif; other site 293614000303 Walker B; other site 293614000304 D-loop; other site 293614000305 H-loop/switch region; other site 293614000306 Ribosomal protein L28 [Translation, ribosomal structure and biogenesis]; Region: RpmB; COG0227 293614000307 50S ribosomal protein L31; Provisional; Region: PRK01397 293614000308 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 293614000309 G1 box; other site 293614000310 GTP/Mg2+ binding site [chemical binding]; other site 293614000311 Switch I region; other site 293614000312 G2 box; other site 293614000313 G3 box; other site 293614000314 Switch II region; other site 293614000315 G4 box; other site 293614000316 G5 box; other site 293614000317 type IV secretion system protein VirB3; Provisional; Region: PRK13899 293614000318 type IV secretion system ATPase VirB4; Provisional; Region: PRK13898 293614000319 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 293614000320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 293614000321 Walker A/P-loop; other site 293614000322 ATP binding site [chemical binding]; other site 293614000323 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 293614000324 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 293614000325 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 293614000326 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 293614000327 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 293614000328 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 293614000329 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 293614000330 phosphate acetyltransferase; Provisional; Region: PRK11890 293614000331 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 293614000332 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 293614000333 propionate/acetate kinase; Provisional; Region: PRK12379 293614000334 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 293614000335 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 293614000336 hypothetical protein; Provisional; Region: PRK13694 293614000337 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 293614000338 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 293614000339 Protein export membrane protein; Region: SecD_SecF; pfam02355 293614000340 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 293614000341 SLBB domain; Region: SLBB; pfam10531 293614000342 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 293614000343 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 293614000344 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 293614000345 Catalytic site [active] 293614000346 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 293614000347 Catalytic site [active] 293614000348 ribonuclease III; Reviewed; Region: rnc; PRK00102 293614000349 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 293614000350 dimerization interface [polypeptide binding]; other site 293614000351 active site 293614000352 metal binding site [ion binding]; metal-binding site 293614000353 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 293614000354 dsRNA binding site [nucleotide binding]; other site 293614000355 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 293614000356 GTPase Era; Reviewed; Region: era; PRK00089 293614000357 G1 box; other site 293614000358 GTP/Mg2+ binding site [chemical binding]; other site 293614000359 Switch I region; other site 293614000360 G2 box; other site 293614000361 Switch II region; other site 293614000362 G3 box; other site 293614000363 G4 box; other site 293614000364 G5 box; other site 293614000365 KH domain; Region: KH_2; pfam07650 293614000366 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 293614000367 active site 293614000368 putative DNA-binding cleft [nucleotide binding]; other site 293614000369 dimer interface [polypeptide binding]; other site 293614000370 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 293614000371 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 293614000372 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 293614000373 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 293614000374 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 293614000375 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 293614000376 Walker A motif; other site 293614000377 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 293614000378 HflK protein; Region: hflK; TIGR01933 293614000379 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 293614000380 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 293614000381 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 293614000382 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 293614000383 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 293614000384 protein binding site [polypeptide binding]; other site 293614000385 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 293614000386 protein binding site [polypeptide binding]; other site 293614000387 hypothetical protein; Validated; Region: PRK01415 293614000388 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 293614000389 active site residue [active] 293614000390 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 293614000391 Iron-sulfur protein interface; other site 293614000392 proximal quinone binding site [chemical binding]; other site 293614000393 SdhD (CybS) interface [polypeptide binding]; other site 293614000394 proximal heme binding site [chemical binding]; other site 293614000395 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 293614000396 putative SdhC subunit interface [polypeptide binding]; other site 293614000397 putative proximal heme binding site [chemical binding]; other site 293614000398 putative Iron-sulfur protein interface [polypeptide binding]; other site 293614000399 putative proximal quinone binding site; other site 293614000400 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 293614000401 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 293614000402 L-aspartate oxidase; Provisional; Region: PRK06175 293614000403 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 293614000404 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 293614000405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 293614000406 dimer interface [polypeptide binding]; other site 293614000407 conserved gate region; other site 293614000408 putative PBP binding loops; other site 293614000409 ABC-ATPase subunit interface; other site 293614000410 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 293614000411 S17 interaction site [polypeptide binding]; other site 293614000412 S8 interaction site; other site 293614000413 16S rRNA interaction site [nucleotide binding]; other site 293614000414 streptomycin interaction site [chemical binding]; other site 293614000415 23S rRNA interaction site [nucleotide binding]; other site 293614000416 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 293614000417 30S ribosomal protein S7; Validated; Region: PRK05302 293614000418 elongation factor G; Reviewed; Region: PRK00007 293614000419 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 293614000420 G1 box; other site 293614000421 putative GEF interaction site [polypeptide binding]; other site 293614000422 GTP/Mg2+ binding site [chemical binding]; other site 293614000423 Switch I region; other site 293614000424 G2 box; other site 293614000425 G3 box; other site 293614000426 Switch II region; other site 293614000427 G4 box; other site 293614000428 G5 box; other site 293614000429 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 293614000430 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 293614000431 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 293614000432 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 293614000433 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 293614000434 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 293614000435 putative homodimer interface [polypeptide binding]; other site 293614000436 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 293614000437 heterodimer interface [polypeptide binding]; other site 293614000438 homodimer interface [polypeptide binding]; other site 293614000439 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 293614000440 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 293614000441 23S rRNA interface [nucleotide binding]; other site 293614000442 putative thiostrepton binding site; other site 293614000443 L7/L12 interface [polypeptide binding]; other site 293614000444 L25 interface [polypeptide binding]; other site 293614000445 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 293614000446 mRNA/rRNA interface [nucleotide binding]; other site 293614000447 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 293614000448 23S rRNA interface [nucleotide binding]; other site 293614000449 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 293614000450 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 293614000451 core dimer interface [polypeptide binding]; other site 293614000452 peripheral dimer interface [polypeptide binding]; other site 293614000453 L10 interface [polypeptide binding]; other site 293614000454 L11 interface [polypeptide binding]; other site 293614000455 putative EF-Tu interaction site [polypeptide binding]; other site 293614000456 putative EF-G interaction site [polypeptide binding]; other site 293614000457 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 293614000458 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 293614000459 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 293614000460 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 293614000461 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 293614000462 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 293614000463 RPB3 interaction site [polypeptide binding]; other site 293614000464 RPB1 interaction site [polypeptide binding]; other site 293614000465 RPB11 interaction site [polypeptide binding]; other site 293614000466 RPB10 interaction site [polypeptide binding]; other site 293614000467 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 293614000468 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 293614000469 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 293614000470 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 293614000471 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 293614000472 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 293614000473 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 293614000474 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 293614000475 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 293614000476 DNA binding site [nucleotide binding] 293614000477 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 293614000478 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 293614000479 multifunctional aminopeptidase A; Provisional; Region: PRK00913 293614000480 interface (dimer of trimers) [polypeptide binding]; other site 293614000481 Substrate-binding/catalytic site; other site 293614000482 Zn-binding sites [ion binding]; other site 293614000483 ATPase MipZ; Region: MipZ; pfam09140 293614000484 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 293614000485 P-loop; other site 293614000486 Magnesium ion binding site [ion binding]; other site 293614000487 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 293614000488 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 293614000489 dimer interface [polypeptide binding]; other site 293614000490 anticodon binding site; other site 293614000491 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 293614000492 homodimer interface [polypeptide binding]; other site 293614000493 motif 1; other site 293614000494 active site 293614000495 motif 2; other site 293614000496 GAD domain; Region: GAD; pfam02938 293614000497 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 293614000498 active site 293614000499 motif 3; other site 293614000500 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 293614000501 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 293614000502 dihydrodipicolinate reductase; Provisional; Region: PRK00048 293614000503 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 293614000504 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 293614000505 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 293614000506 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 293614000507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 293614000508 substrate binding pocket [chemical binding]; other site 293614000509 membrane-bound complex binding site; other site 293614000510 hinge residues; other site 293614000511 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 293614000512 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 293614000513 GatB domain; Region: GatB_Yqey; smart00845 293614000514 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 293614000515 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 293614000516 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 293614000517 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 293614000518 ribosome recycling factor; Reviewed; Region: frr; PRK00083 293614000519 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 293614000520 hinge region; other site 293614000521 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 293614000522 putative nucleotide binding site [chemical binding]; other site 293614000523 uridine monophosphate binding site [chemical binding]; other site 293614000524 homohexameric interface [polypeptide binding]; other site 293614000525 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK06580 293614000526 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 293614000527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 293614000528 putative substrate translocation pore; other site 293614000529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 293614000530 Protein of unknown function (DUF2674); Region: DUF2674; pfam10879 293614000531 Transposase IS200 like; Region: Y1_Tnp; cl00848 293614000532 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 293614000533 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 293614000534 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 293614000535 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 293614000536 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 293614000537 Surface antigen; Region: Bac_surface_Ag; pfam01103 293614000538 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 293614000539 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 293614000540 active site 293614000541 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 293614000542 protein binding site [polypeptide binding]; other site 293614000543 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 293614000544 putative substrate binding region [chemical binding]; other site 293614000545 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 293614000546 putative RNA binding site [nucleotide binding]; other site 293614000547 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 293614000548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 293614000549 S-adenosylmethionine binding site [chemical binding]; other site 293614000550 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 293614000551 putative coenzyme Q binding site [chemical binding]; other site 293614000552 Rickettsial palindromic element RPE3 domain; Region: RPE3; TIGR03775 293614000553 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 293614000554 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 293614000555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 293614000556 RNA methyltransferase, RsmE family; Region: TIGR00046 293614000557 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 293614000558 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 293614000559 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 293614000560 IHF dimer interface [polypeptide binding]; other site 293614000561 IHF - DNA interface [nucleotide binding]; other site 293614000562 DNA polymerase III subunit delta'; Validated; Region: PRK06581 293614000563 signal recognition particle protein; Provisional; Region: PRK10867 293614000564 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 293614000565 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 293614000566 P loop; other site 293614000567 GTP binding site [chemical binding]; other site 293614000568 Signal peptide binding domain; Region: SRP_SPB; pfam02978 293614000569 coproporphyrinogen III oxidase; Provisional; Region: PRK06582 293614000570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 293614000571 FeS/SAM binding site; other site 293614000572 HemN C-terminal domain; Region: HemN_C; pfam06969 293614000573 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 293614000574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 293614000575 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 293614000576 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 293614000577 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 293614000578 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 293614000579 active site 293614000580 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 293614000581 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 293614000582 E3 interaction surface; other site 293614000583 lipoyl attachment site [posttranslational modification]; other site 293614000584 e3 binding domain; Region: E3_binding; pfam02817 293614000585 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 293614000586 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 293614000587 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 293614000588 TPP-binding site [chemical binding]; other site 293614000589 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 293614000590 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 293614000591 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 293614000592 active site 293614000593 Zn binding site [ion binding]; other site 293614000594 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 293614000595 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 293614000596 Walker A/P-loop; other site 293614000597 ATP binding site [chemical binding]; other site 293614000598 Q-loop/lid; other site 293614000599 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 293614000600 ABC transporter signature motif; other site 293614000601 Walker B; other site 293614000602 D-loop; other site 293614000603 H-loop/switch region; other site 293614000604 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 293614000605 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 293614000606 chaperone protein DnaJ; Provisional; Region: PRK14300 293614000607 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 293614000608 HSP70 interaction site [polypeptide binding]; other site 293614000609 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 293614000610 substrate binding site [polypeptide binding]; other site 293614000611 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 293614000612 Zn binding sites [ion binding]; other site 293614000613 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 293614000614 dimer interface [polypeptide binding]; other site 293614000615 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 293614000616 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 293614000617 nucleotide binding site [chemical binding]; other site 293614000618 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 293614000619 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 293614000620 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 293614000621 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 293614000622 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 293614000623 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 293614000624 diiron binding motif [ion binding]; other site 293614000625 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 293614000626 Subunit III/VIIa interface [polypeptide binding]; other site 293614000627 Phospholipid binding site [chemical binding]; other site 293614000628 Subunit I/III interface [polypeptide binding]; other site 293614000629 Subunit III/VIb interface [polypeptide binding]; other site 293614000630 Subunit III/VIa interface; other site 293614000631 Subunit III/Vb interface [polypeptide binding]; other site 293614000632 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 293614000633 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 293614000634 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 293614000635 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 293614000636 trimer interface [polypeptide binding]; other site 293614000637 active site 293614000638 substrate binding site [chemical binding]; other site 293614000639 CoA binding site [chemical binding]; other site 293614000640 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 293614000641 Transglycosylase; Region: Transgly; pfam00912 293614000642 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 293614000643 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 293614000644 Autotransporter beta-domain; Region: Autotransporter; cl17461 293614000645 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 293614000646 Ligand Binding Site [chemical binding]; other site 293614000647 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 293614000648 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 293614000649 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 293614000650 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 293614000651 catalytic loop [active] 293614000652 iron binding site [ion binding]; other site 293614000653 chaperone protein HscA; Provisional; Region: hscA; PRK01433 293614000654 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 293614000655 nucleotide binding site [chemical binding]; other site 293614000656 co-chaperone HscB; Provisional; Region: hscB; PRK01356 293614000657 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 293614000658 HSP70 interaction site [polypeptide binding]; other site 293614000659 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 293614000660 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 293614000661 RNA/DNA hybrid binding site [nucleotide binding]; other site 293614000662 active site 293614000663 excinuclease ABC subunit B; Provisional; Region: PRK05298 293614000664 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 293614000665 ATP binding site [chemical binding]; other site 293614000666 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 293614000667 nucleotide binding region [chemical binding]; other site 293614000668 ATP-binding site [chemical binding]; other site 293614000669 Ultra-violet resistance protein B; Region: UvrB; pfam12344 293614000670 UvrB/uvrC motif; Region: UVR; pfam02151 293614000671 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 293614000672 GSH binding site [chemical binding]; other site 293614000673 catalytic residues [active] 293614000674 DNA gyrase subunit A; Validated; Region: PRK05560 293614000675 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 293614000676 CAP-like domain; other site 293614000677 active site 293614000678 primary dimer interface [polypeptide binding]; other site 293614000679 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 293614000680 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 293614000681 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 293614000682 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 293614000683 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 293614000684 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 293614000685 active site 293614000686 catalytic residues [active] 293614000687 metal binding site [ion binding]; metal-binding site 293614000688 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 293614000689 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 293614000690 putative active site [active] 293614000691 substrate binding site [chemical binding]; other site 293614000692 putative cosubstrate binding site; other site 293614000693 catalytic site [active] 293614000694 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 293614000695 substrate binding site [chemical binding]; other site 293614000696 Predicted ATPase [General function prediction only]; Region: COG1485 293614000697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 293614000698 Walker A motif; other site 293614000699 ATP binding site [chemical binding]; other site 293614000700 Walker B motif; other site 293614000701 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: PRK01424 293614000702 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 293614000703 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 293614000704 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 293614000705 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 293614000706 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 293614000707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 293614000708 Walker A/P-loop; other site 293614000709 ATP binding site [chemical binding]; other site 293614000710 Q-loop/lid; other site 293614000711 ABC transporter signature motif; other site 293614000712 Walker B; other site 293614000713 D-loop; other site 293614000714 H-loop/switch region; other site 293614000715 Protein of unknown function (DUF2671); Region: DUF2671; pfam10877 293614000716 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 293614000717 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 293614000718 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 293614000719 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 293614000720 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 293614000721 putative metal binding site; other site 293614000722 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 293614000723 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 293614000724 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 293614000725 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 293614000726 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 293614000727 ATP binding site [chemical binding]; other site 293614000728 active site 293614000729 substrate binding site [chemical binding]; other site 293614000730 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 293614000731 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 293614000732 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 293614000733 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 293614000734 active site 293614000735 dimer interface [polypeptide binding]; other site 293614000736 motif 1; other site 293614000737 motif 2; other site 293614000738 motif 3; other site 293614000739 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 293614000740 anticodon binding site; other site 293614000741 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; cl02380 293614000742 Protein of unknown function (DUF2660); Region: DUF2660; pfam10859 293614000743 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 293614000744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 293614000745 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 293614000746 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 293614000747 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 293614000748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 293614000749 ATP binding site [chemical binding]; other site 293614000750 Mg2+ binding site [ion binding]; other site 293614000751 G-X-G motif; other site 293614000752 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 293614000753 anchoring element; other site 293614000754 dimer interface [polypeptide binding]; other site 293614000755 ATP binding site [chemical binding]; other site 293614000756 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 293614000757 active site 293614000758 metal binding site [ion binding]; metal-binding site 293614000759 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 293614000760 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 293614000761 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 293614000762 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 293614000763 protein binding site [polypeptide binding]; other site 293614000764 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 293614000765 Catalytic dyad [active] 293614000766 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 293614000767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 293614000768 dimer interface [polypeptide binding]; other site 293614000769 phosphorylation site [posttranslational modification] 293614000770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 293614000771 ATP binding site [chemical binding]; other site 293614000772 Mg2+ binding site [ion binding]; other site 293614000773 G-X-G motif; other site 293614000774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 293614000775 Tetratricopeptide repeat; Region: TPR_6; pfam13174 293614000776 Protein of unknown function (DUF2659); Region: DUF2659; pfam10858 293614000777 FOG: WD40-like repeat [Function unknown]; Region: COG1520 293614000778 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 293614000779 Trp docking motif [polypeptide binding]; other site 293614000780 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 293614000781 23S rRNA interface [nucleotide binding]; other site 293614000782 L3 interface [polypeptide binding]; other site 293614000783 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 293614000784 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 293614000785 DCoH dimer interaction site [polypeptide binding]; other site 293614000786 aromatic arch; other site 293614000787 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 293614000788 DCoH tetramer interaction site [polypeptide binding]; other site 293614000789 substrate binding site [chemical binding]; other site 293614000790 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 293614000791 putative active site [active] 293614000792 Ap4A binding site [chemical binding]; other site 293614000793 nudix motif; other site 293614000794 putative metal binding site [ion binding]; other site 293614000795 response regulator PleD; Reviewed; Region: pleD; PRK09581 293614000796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 293614000797 active site 293614000798 phosphorylation site [posttranslational modification] 293614000799 intermolecular recognition site; other site 293614000800 dimerization interface [polypeptide binding]; other site 293614000801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 293614000802 active site 293614000803 phosphorylation site [posttranslational modification] 293614000804 intermolecular recognition site; other site 293614000805 dimerization interface [polypeptide binding]; other site 293614000806 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 293614000807 metal binding site [ion binding]; metal-binding site 293614000808 active site 293614000809 I-site; other site 293614000810 elongation factor P; Validated; Region: PRK00529 293614000811 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 293614000812 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 293614000813 RNA binding site [nucleotide binding]; other site 293614000814 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 293614000815 RNA binding site [nucleotide binding]; other site 293614000816 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 293614000817 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 293614000818 active site 293614000819 Domain of unknown function (DUF2610); Region: DUF2610; pfam11020 293614000820 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 293614000821 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 293614000822 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 293614000823 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 293614000824 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 293614000825 HlyD family secretion protein; Region: HlyD_3; pfam13437 293614000826 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 293614000827 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 293614000828 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 293614000829 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 293614000830 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 293614000831 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 293614000832 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 293614000833 FAD binding domain; Region: FAD_binding_4; pfam01565 293614000834 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 293614000835 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 293614000836 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 293614000837 ATP-grasp domain; Region: ATP-grasp_4; cl17255 293614000838 Cell division protein FtsQ; Region: FtsQ; pfam03799 293614000839 cell division protein FtsA; Region: ftsA; TIGR01174 293614000840 Cell division protein FtsA; Region: FtsA; smart00842 293614000841 Cell division protein FtsA; Region: FtsA; pfam14450 293614000842 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 293614000843 Cytochrome c2 [Energy production and conversion]; Region: COG3474 293614000844 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 293614000845 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 293614000846 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 293614000847 RNA binding site [nucleotide binding]; other site 293614000848 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 293614000849 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 293614000850 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 293614000851 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 293614000852 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 293614000853 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 293614000854 RNA binding surface [nucleotide binding]; other site 293614000855 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 293614000856 active site 293614000857 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 293614000858 Beta-lactamase; Region: Beta-lactamase; pfam00144 293614000859 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 293614000860 putative catalytic site [active] 293614000861 putative phosphate binding site [ion binding]; other site 293614000862 active site 293614000863 metal binding site A [ion binding]; metal-binding site 293614000864 DNA binding site [nucleotide binding] 293614000865 putative AP binding site [nucleotide binding]; other site 293614000866 putative metal binding site B [ion binding]; other site 293614000867 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 293614000868 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 293614000869 tetramer interface [polypeptide binding]; other site 293614000870 TPP-binding site [chemical binding]; other site 293614000871 heterodimer interface [polypeptide binding]; other site 293614000872 phosphorylation loop region [posttranslational modification] 293614000873 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 293614000874 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 293614000875 alpha subunit interface [polypeptide binding]; other site 293614000876 TPP binding site [chemical binding]; other site 293614000877 heterodimer interface [polypeptide binding]; other site 293614000878 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 293614000879 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 293614000880 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 293614000881 G1 box; other site 293614000882 putative GEF interaction site [polypeptide binding]; other site 293614000883 GTP/Mg2+ binding site [chemical binding]; other site 293614000884 Switch I region; other site 293614000885 G2 box; other site 293614000886 G3 box; other site 293614000887 Switch II region; other site 293614000888 G4 box; other site 293614000889 G5 box; other site 293614000890 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 293614000891 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 293614000892 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 293614000893 isocitrate dehydrogenase; Validated; Region: PRK09222 293614000894 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 293614000895 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 293614000896 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12507 293614000897 Predicted subunit of the Multisubunit Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: COG1563 293614000898 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 293614000899 Protein of unknown function (DUF2670); Region: DUF2670; pfam10875 293614000900 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 293614000901 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 293614000902 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 293614000903 [2Fe-2S] cluster binding site [ion binding]; other site 293614000904 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 293614000905 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 293614000906 Qi binding site; other site 293614000907 intrachain domain interface; other site 293614000908 interchain domain interface [polypeptide binding]; other site 293614000909 cytochrome b; Provisional; Region: CYTB; MTH00156 293614000910 heme bH binding site [chemical binding]; other site 293614000911 heme bL binding site [chemical binding]; other site 293614000912 Qo binding site; other site 293614000913 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 293614000914 interchain domain interface [polypeptide binding]; other site 293614000915 intrachain domain interface; other site 293614000916 Qi binding site; other site 293614000917 Qo binding site; other site 293614000918 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 293614000919 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 293614000920 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 293614000921 putative dimer interface [polypeptide binding]; other site 293614000922 PCRF domain; Region: PCRF; pfam03462 293614000923 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 293614000924 RF-1 domain; Region: RF-1; pfam00472 293614000925 GTP-binding protein LepA; Provisional; Region: PRK05433 293614000926 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 293614000927 G1 box; other site 293614000928 putative GEF interaction site [polypeptide binding]; other site 293614000929 GTP/Mg2+ binding site [chemical binding]; other site 293614000930 Switch I region; other site 293614000931 G2 box; other site 293614000932 G3 box; other site 293614000933 Switch II region; other site 293614000934 G4 box; other site 293614000935 G5 box; other site 293614000936 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 293614000937 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 293614000938 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 293614000939 Phage capsid family; Region: Phage_capsid; pfam05065 293614000940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 293614000941 sequence-specific DNA binding site [nucleotide binding]; other site 293614000942 salt bridge; other site 293614000943 Transposase IS200 like; Region: Y1_Tnp; cl00848 293614000944 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 293614000945 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 293614000946 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 293614000947 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06588 293614000948 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 293614000949 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 293614000950 putative active site [active] 293614000951 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06589 293614000952 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 293614000953 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06591 293614000954 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 293614000955 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 293614000956 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 293614000957 VirB7 interaction site; other site 293614000958 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 293614000959 Protein of unknown function (DUF2706); Region: DUF2706; pfam10913 293614000960 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 293614000961 Type IV secretory pathway, VirB9 components [Intracellular trafficking and secretion]; Region: VirB9; COG3504 293614000962 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 293614000963 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 293614000964 type IV secretion system ATPase VirB11; Provisional; Region: PRK13900 293614000965 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 293614000966 Walker A motif; other site 293614000967 hexamer interface [polypeptide binding]; other site 293614000968 ATP binding site [chemical binding]; other site 293614000969 Walker B motif; other site 293614000970 type IV secretion system component VirD4; Provisional; Region: PRK13897 293614000971 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 293614000972 Walker A motif; other site 293614000973 ATP binding site [chemical binding]; other site 293614000974 Walker B motif; other site 293614000975 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 293614000976 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 293614000977 Transposase IS200 like; Region: Y1_Tnp; cl00848 293614000978 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 293614000979 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 293614000980 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 293614000981 active site 293614000982 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 293614000983 MutS domain I; Region: MutS_I; pfam01624 293614000984 MutS domain II; Region: MutS_II; pfam05188 293614000985 MutS domain III; Region: MutS_III; pfam05192 293614000986 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 293614000987 Walker A/P-loop; other site 293614000988 ATP binding site [chemical binding]; other site 293614000989 Q-loop/lid; other site 293614000990 ABC transporter signature motif; other site 293614000991 Walker B; other site 293614000992 D-loop; other site 293614000993 H-loop/switch region; other site 293614000994 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 293614000995 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 293614000996 Peptidase family M23; Region: Peptidase_M23; pfam01551 293614000997 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 293614000998 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 293614000999 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 293614001000 translocation protein TolB; Provisional; Region: tolB; PRK05137 293614001001 TolB amino-terminal domain; Region: TolB_N; pfam04052 293614001002 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 293614001003 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 293614001004 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 293614001005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 293614001006 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 293614001007 DNA binding residues [nucleotide binding] 293614001008 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 293614001009 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 293614001010 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 293614001011 Ligand Binding Site [chemical binding]; other site 293614001012 amino acid transporter; Region: 2A0306; TIGR00909 293614001013 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 293614001014 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 293614001015 dimer interface [polypeptide binding]; other site 293614001016 motif 1; other site 293614001017 active site 293614001018 motif 2; other site 293614001019 motif 3; other site 293614001020 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 293614001021 anticodon binding site; other site 293614001022 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 293614001023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 293614001024 ABC transporter signature motif; other site 293614001025 Walker B; other site 293614001026 TolQ protein; Region: tolQ; TIGR02796 293614001027 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 293614001028 TolR protein; Region: tolR; TIGR02801 293614001029 CAAX protease self-immunity; Region: Abi; cl00558 293614001030 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 293614001031 HD domain; Region: HD_4; pfam13328 293614001032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 293614001033 metabolite-proton symporter; Region: 2A0106; TIGR00883 293614001034 putative substrate translocation pore; other site 293614001035 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 293614001036 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 293614001037 HlyD family secretion protein; Region: HlyD_3; pfam13437 293614001038 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 293614001039 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 293614001040 Walker A/P-loop; other site 293614001041 ATP binding site [chemical binding]; other site 293614001042 Q-loop/lid; other site 293614001043 ABC transporter signature motif; other site 293614001044 Walker B; other site 293614001045 D-loop; other site 293614001046 H-loop/switch region; other site 293614001047 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 293614001048 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 293614001049 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 293614001050 nucleotide binding site/active site [active] 293614001051 HIT family signature motif; other site 293614001052 catalytic residue [active] 293614001053 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 293614001054 active site 293614001055 HslU subunit interaction site [polypeptide binding]; other site 293614001056 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 293614001057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 293614001058 Walker A motif; other site 293614001059 ATP binding site [chemical binding]; other site 293614001060 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 293614001061 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 293614001062 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 293614001063 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 293614001064 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 293614001065 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 293614001066 dimerization interface [polypeptide binding]; other site 293614001067 frataxin-like protein; Provisional; Region: cyaY; PRK01379 293614001068 putative iron binding site [ion binding]; other site 293614001069 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 293614001070 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 293614001071 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 293614001072 HIGH motif; other site 293614001073 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 293614001074 active site 293614001075 KMSKS motif; other site 293614001076 DNA topoisomerase I; Validated; Region: PRK06599 293614001077 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 293614001078 active site 293614001079 interdomain interaction site; other site 293614001080 putative metal-binding site [ion binding]; other site 293614001081 nucleotide binding site [chemical binding]; other site 293614001082 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 293614001083 domain I; other site 293614001084 DNA binding groove [nucleotide binding] 293614001085 phosphate binding site [ion binding]; other site 293614001086 domain II; other site 293614001087 domain III; other site 293614001088 nucleotide binding site [chemical binding]; other site 293614001089 catalytic site [active] 293614001090 domain IV; other site 293614001091 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 293614001092 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 293614001093 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 293614001094 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 293614001095 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 293614001096 dimer interface [polypeptide binding]; other site 293614001097 decamer (pentamer of dimers) interface [polypeptide binding]; other site 293614001098 catalytic triad [active] 293614001099 peroxidatic and resolving cysteines [active] 293614001100 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 293614001101 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 293614001102 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 293614001103 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 293614001104 Sulfatase; Region: Sulfatase; pfam00884 293614001105 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 293614001106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 293614001107 non-specific DNA binding site [nucleotide binding]; other site 293614001108 salt bridge; other site 293614001109 sequence-specific DNA binding site [nucleotide binding]; other site 293614001110 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 293614001111 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 293614001112 NADP binding site [chemical binding]; other site 293614001113 active site 293614001114 putative substrate binding site [chemical binding]; other site 293614001115 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 293614001116 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 293614001117 NAD(P) binding site [chemical binding]; other site 293614001118 homodimer interface [polypeptide binding]; other site 293614001119 substrate binding site [chemical binding]; other site 293614001120 active site 293614001121 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 293614001122 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 293614001123 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 293614001124 active site 293614001125 homodimer interface [polypeptide binding]; other site 293614001126 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 293614001127 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 293614001128 active site 293614001129 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 293614001130 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 293614001131 active site 293614001132 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 293614001133 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 293614001134 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 293614001135 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 293614001136 catalytic site [active] 293614001137 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 293614001138 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 293614001139 putative ADP-binding pocket [chemical binding]; other site 293614001140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 293614001141 Walker B; other site 293614001142 D-loop; other site 293614001143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 293614001144 Walker A/P-loop; other site 293614001145 ATP binding site [chemical binding]; other site 293614001146 Q-loop/lid; other site 293614001147 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 293614001148 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 293614001149 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 293614001150 RNA binding surface [nucleotide binding]; other site 293614001151 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 293614001152 UbiA prenyltransferase family; Region: UbiA; pfam01040 293614001153 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 293614001154 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 293614001155 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 293614001156 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 293614001157 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 293614001158 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 293614001159 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 293614001160 RimM N-terminal domain; Region: RimM; pfam01782 293614001161 PRC-barrel domain; Region: PRC; pfam05239 293614001162 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 293614001163 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 293614001164 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 293614001165 hypothetical protein; Provisional; Region: PRK14388 293614001166 NADH dehydrogenase subunit E; Validated; Region: PRK07539 293614001167 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 293614001168 putative dimer interface [polypeptide binding]; other site 293614001169 [2Fe-2S] cluster binding site [ion binding]; other site 293614001170 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 293614001171 NADH dehydrogenase subunit D; Validated; Region: PRK06075 293614001172 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 293614001173 catalytic site [active] 293614001174 metal binding site [ion binding]; metal-binding site 293614001175 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 293614001176 active site 293614001177 GIY-YIG motif/motif A; other site 293614001178 catalytic site [active] 293614001179 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 293614001180 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 293614001181 NADH dehydrogenase subunit B; Validated; Region: PRK06411 293614001182 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 293614001183 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 293614001184 O-Antigen ligase; Region: Wzy_C; pfam04932 293614001185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 293614001186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 293614001187 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 293614001188 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 293614001189 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 293614001190 active site 293614001191 DNA binding site [nucleotide binding] 293614001192 Int/Topo IB signature motif; other site 293614001193 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06603 293614001194 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 293614001195 NAD binding site [chemical binding]; other site 293614001196 homotetramer interface [polypeptide binding]; other site 293614001197 homodimer interface [polypeptide binding]; other site 293614001198 substrate binding site [chemical binding]; other site 293614001199 active site 293614001200 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 293614001201 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 293614001202 putative active site [active] 293614001203 catalytic triad [active] 293614001204 putative dimer interface [polypeptide binding]; other site 293614001205 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984 293614001206 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 293614001207 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 293614001208 TM-ABC transporter signature motif; other site 293614001209 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 293614001210 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 293614001211 Walker A/P-loop; other site 293614001212 ATP binding site [chemical binding]; other site 293614001213 Q-loop/lid; other site 293614001214 ABC transporter signature motif; other site 293614001215 Walker B; other site 293614001216 D-loop; other site 293614001217 H-loop/switch region; other site 293614001218 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 293614001219 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 293614001220 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 293614001221 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 293614001222 active site 293614001223 HIGH motif; other site 293614001224 KMSKS motif; other site 293614001225 Predicted permeases [General function prediction only]; Region: COG0679 293614001226 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 293614001227 Malic enzyme, N-terminal domain; Region: malic; pfam00390 293614001228 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 293614001229 putative NAD(P) binding site [chemical binding]; other site 293614001230 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 293614001231 Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; Region: Sec7; cd00171 293614001232 active site/putative ARF binding site [active] 293614001233 Transposase IS200 like; Region: Y1_Tnp; cl00848 293614001234 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 293614001235 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 293614001236 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 293614001237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 293614001238 metabolite-proton symporter; Region: 2A0106; TIGR00883 293614001239 putative substrate translocation pore; other site 293614001240 Rickettsial palindromic element RPE3 domain; Region: RPE3; TIGR03775 293614001241 malate dehydrogenase; Reviewed; Region: PRK06223 293614001242 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 293614001243 NAD(P) binding site [chemical binding]; other site 293614001244 dimer interface [polypeptide binding]; other site 293614001245 tetramer (dimer of dimers) interface [polypeptide binding]; other site 293614001246 substrate binding site [chemical binding]; other site 293614001247 TLC ATP/ADP transporter; Region: TLC; pfam03219 293614001248 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 293614001249 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 293614001250 Ligand binding site; other site 293614001251 oligomer interface; other site 293614001252 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 293614001253 nudix motif; other site 293614001254 Rickettsial palindromic element RPE4 domain; Region: RPE4; TIGR03777 293614001255 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 293614001256 GTP cyclohydrolase I; Provisional; Region: PLN03044 293614001257 active site 293614001258 prolyl-tRNA synthetase; Provisional; Region: PRK12325 293614001259 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 293614001260 dimer interface [polypeptide binding]; other site 293614001261 motif 1; other site 293614001262 active site 293614001263 motif 2; other site 293614001264 motif 3; other site 293614001265 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 293614001266 anticodon binding site; other site 293614001267 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 293614001268 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 293614001269 RuvA N terminal domain; Region: RuvA_N; pfam01330 293614001270 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 293614001271 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 293614001272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 293614001273 Walker A motif; other site 293614001274 ATP binding site [chemical binding]; other site 293614001275 Walker B motif; other site 293614001276 arginine finger; other site 293614001277 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 293614001278 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 293614001279 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 293614001280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 293614001281 Walker A/P-loop; other site 293614001282 ATP binding site [chemical binding]; other site 293614001283 Q-loop/lid; other site 293614001284 ABC transporter signature motif; other site 293614001285 Walker B; other site 293614001286 D-loop; other site 293614001287 H-loop/switch region; other site 293614001288 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 293614001289 muropeptide transporter; Reviewed; Region: ampG; PRK11902 293614001290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 293614001291 putative substrate translocation pore; other site 293614001292 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 293614001293 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 293614001294 Entericidin EcnA/B family; Region: Entericidin; cl02322 293614001295 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 293614001296 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 293614001297 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 293614001298 BON domain; Region: BON; pfam04972 293614001299 BON domain; Region: BON; pfam04972 293614001300 Intracellular septation protein A [Cell division and chromosome partitioning]; Region: COG2917 293614001301 Iron permease FTR1 family; Region: FTR1; cl00475 293614001302 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 293614001303 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 293614001304 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 293614001305 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 293614001306 active site 293614001307 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 293614001308 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 293614001309 catalytic residues [active] 293614001310 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 293614001311 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 293614001312 tandem repeat interface [polypeptide binding]; other site 293614001313 oligomer interface [polypeptide binding]; other site 293614001314 active site residues [active] 293614001315 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 293614001316 trimer interface [polypeptide binding]; other site 293614001317 active site 293614001318 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 293614001319 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 293614001320 N-acetyl-D-glucosamine binding site [chemical binding]; other site 293614001321 catalytic residue [active] 293614001322 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 293614001323 dimer interface [polypeptide binding]; other site 293614001324 catalytic triad [active] 293614001325 Rickettsial palindromic element RPE3 domain; Region: RPE3; TIGR03775 293614001326 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 293614001327 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 293614001328 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 293614001329 catalytic triad [active] 293614001330 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 293614001331 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 293614001332 Subunit I/III interface [polypeptide binding]; other site 293614001333 D-pathway; other site 293614001334 Subunit I/VIIc interface [polypeptide binding]; other site 293614001335 Subunit I/IV interface [polypeptide binding]; other site 293614001336 Subunit I/II interface [polypeptide binding]; other site 293614001337 Low-spin heme (heme a) binding site [chemical binding]; other site 293614001338 Subunit I/VIIa interface [polypeptide binding]; other site 293614001339 Subunit I/VIa interface [polypeptide binding]; other site 293614001340 Dimer interface; other site 293614001341 Putative water exit pathway; other site 293614001342 Binuclear center (heme a3/CuB) [ion binding]; other site 293614001343 K-pathway; other site 293614001344 Subunit I/Vb interface [polypeptide binding]; other site 293614001345 Putative proton exit pathway; other site 293614001346 Subunit I/VIb interface; other site 293614001347 Subunit I/VIc interface [polypeptide binding]; other site 293614001348 Electron transfer pathway; other site 293614001349 Subunit I/VIIIb interface [polypeptide binding]; other site 293614001350 Subunit I/VIIb interface [polypeptide binding]; other site 293614001351 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 293614001352 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 293614001353 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 293614001354 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 293614001355 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 293614001356 Peptidase family M23; Region: Peptidase_M23; pfam01551 293614001357 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 293614001358 lipoprotein signal peptidase; Provisional; Region: PRK14787 293614001359 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 293614001360 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 293614001361 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01368 293614001362 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 293614001363 Rickettsial palindromic element RPE3 domain; Region: RPE3; TIGR03775 293614001364 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 293614001365 cell division protein FtsW; Region: ftsW; TIGR02614 293614001366 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 293614001367 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 293614001368 active site 293614001369 homodimer interface [polypeptide binding]; other site 293614001370 phosphoglucomutase; Validated; Region: PRK07564 293614001371 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 293614001372 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 293614001373 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 293614001374 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 293614001375 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 293614001376 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 293614001377 diaminopimelate epimerase; Region: DapF; TIGR00652 293614001378 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 293614001379 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 293614001380 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 293614001381 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 293614001382 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 293614001383 FeS/SAM binding site; other site 293614001384 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 293614001385 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 293614001386 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 293614001387 dimer interface [polypeptide binding]; other site 293614001388 motif 1; other site 293614001389 active site 293614001390 motif 2; other site 293614001391 motif 3; other site 293614001392 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 293614001393 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 293614001394 putative tRNA-binding site [nucleotide binding]; other site 293614001395 B3/4 domain; Region: B3_4; pfam03483 293614001396 tRNA synthetase B5 domain; Region: B5; smart00874 293614001397 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 293614001398 dimer interface [polypeptide binding]; other site 293614001399 motif 1; other site 293614001400 motif 3; other site 293614001401 motif 2; other site 293614001402 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 293614001403 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 293614001404 DNA polymerase III subunit beta; Validated; Region: PRK05643 293614001405 putative DNA binding surface [nucleotide binding]; other site 293614001406 dimer interface [polypeptide binding]; other site 293614001407 beta-clamp/clamp loader binding surface; other site 293614001408 beta-clamp/translesion DNA polymerase binding surface; other site 293614001409 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 293614001410 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 293614001411 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 293614001412 HIGH motif; other site 293614001413 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 293614001414 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 293614001415 active site 293614001416 KMSKS motif; other site 293614001417 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 293614001418 tRNA binding surface [nucleotide binding]; other site 293614001419 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 293614001420 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 293614001421 catalytic site [active] 293614001422 putative active site [active] 293614001423 putative substrate binding site [chemical binding]; other site 293614001424 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 293614001425 Septum formation initiator; Region: DivIC; pfam04977 293614001426 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 293614001427 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 293614001428 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 293614001429 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 293614001430 catalytic residue [active] 293614001431 putative FPP diphosphate binding site; other site 293614001432 putative FPP binding hydrophobic cleft; other site 293614001433 dimer interface [polypeptide binding]; other site 293614001434 putative IPP diphosphate binding site; other site 293614001435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 293614001436 HAMP domain; Region: HAMP; pfam00672 293614001437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 293614001438 dimer interface [polypeptide binding]; other site 293614001439 phosphorylation site [posttranslational modification] 293614001440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 293614001441 ATP binding site [chemical binding]; other site 293614001442 Mg2+ binding site [ion binding]; other site 293614001443 G-X-G motif; other site 293614001444 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 293614001445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 293614001446 active site 293614001447 phosphorylation site [posttranslational modification] 293614001448 intermolecular recognition site; other site 293614001449 dimerization interface [polypeptide binding]; other site 293614001450 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 293614001451 DNA binding site [nucleotide binding] 293614001452 branched-chain amino acid aminotransferase; Validated; Region: PRK06606 293614001453 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 293614001454 homodimer interface [polypeptide binding]; other site 293614001455 substrate-cofactor binding pocket; other site 293614001456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 293614001457 catalytic residue [active] 293614001458 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 293614001459 dihydrodipicolinate synthase; Region: dapA; TIGR00674 293614001460 dimer interface [polypeptide binding]; other site 293614001461 active site 293614001462 catalytic residue [active] 293614001463 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 293614001464 SmpB-tmRNA interface; other site 293614001465 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 293614001466 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 293614001467 catalytic residues [active] 293614001468 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 293614001469 CoA binding domain; Region: CoA_binding; pfam02629 293614001470 CoA-ligase; Region: Ligase_CoA; pfam00549 293614001471 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 293614001472 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 293614001473 CoA-ligase; Region: Ligase_CoA; pfam00549 293614001474 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 293614001475 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 293614001476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 293614001477 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 293614001478 Predicted membrane protein [Function unknown]; Region: COG1238 293614001479 Predicted membrane protein/domain [Function unknown]; Region: COG1714 293614001480 recombination protein RecR; Reviewed; Region: recR; PRK00076 293614001481 RecR protein; Region: RecR; pfam02132 293614001482 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 293614001483 putative active site [active] 293614001484 putative metal-binding site [ion binding]; other site 293614001485 tetramer interface [polypeptide binding]; other site 293614001486 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 293614001487 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 293614001488 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 293614001489 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 293614001490 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 293614001491 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 293614001492 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 293614001493 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 293614001494 Predicted permeases [General function prediction only]; Region: COG0679 293614001495 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 293614001496 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 293614001497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 293614001498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 293614001499 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 293614001500 metal ion-dependent adhesion site (MIDAS); other site 293614001501 Transposase IS200 like; Region: Y1_Tnp; pfam01797 293614001502 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 293614001503 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 293614001504 tetramerization interface [polypeptide binding]; other site 293614001505 NAD(P) binding site [chemical binding]; other site 293614001506 catalytic residues [active] 293614001507 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 293614001508 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 293614001509 active site 293614001510 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 293614001511 Part of AAA domain; Region: AAA_19; pfam13245 293614001512 Family description; Region: UvrD_C_2; pfam13538 293614001513 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 293614001514 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 293614001515 tetramer interface [polypeptide binding]; other site 293614001516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 293614001517 catalytic residue [active] 293614001518 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 293614001519 Found in ATP-dependent protease La (LON); Region: LON; smart00464 293614001520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 293614001521 Walker A motif; other site 293614001522 ATP binding site [chemical binding]; other site 293614001523 Walker B motif; other site 293614001524 arginine finger; other site 293614001525 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 293614001526 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 293614001527 30S subunit binding site; other site 293614001528 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 293614001529 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14171 293614001530 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 293614001531 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 293614001532 homodimer interface [polypeptide binding]; other site 293614001533 NADP binding site [chemical binding]; other site 293614001534 substrate binding site [chemical binding]; other site 293614001535 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 293614001536 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 293614001537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 293614001538 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 293614001539 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 293614001540 Class I ribonucleotide reductase; Region: RNR_I; cd01679 293614001541 active site 293614001542 dimer interface [polypeptide binding]; other site 293614001543 catalytic residues [active] 293614001544 effector binding site; other site 293614001545 R2 peptide binding site; other site 293614001546 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 293614001547 dimer interface [polypeptide binding]; other site 293614001548 putative radical transfer pathway; other site 293614001549 diiron center [ion binding]; other site 293614001550 tyrosyl radical; other site 293614001551 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 293614001552 similar to hypothetical protein 293614001553 Transposase IS200 like; Region: Y1_Tnp; pfam01797 293614001554 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 293614001555 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 293614001556 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 293614001557 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 293614001558 active site 293614001559 substrate binding site [chemical binding]; other site 293614001560 metal binding site [ion binding]; metal-binding site 293614001561 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 293614001562 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 293614001563 Walker A/P-loop; other site 293614001564 ATP binding site [chemical binding]; other site 293614001565 Q-loop/lid; other site 293614001566 ABC transporter signature motif; other site 293614001567 Walker B; other site 293614001568 D-loop; other site 293614001569 H-loop/switch region; other site 293614001570 OstA-like protein; Region: OstA; pfam03968 293614001571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 293614001572 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 293614001573 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 293614001574 putative active site [active] 293614001575 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 293614001576 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 293614001577 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 293614001578 RNase E interface [polypeptide binding]; other site 293614001579 trimer interface [polypeptide binding]; other site 293614001580 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 293614001581 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 293614001582 RNase E interface [polypeptide binding]; other site 293614001583 trimer interface [polypeptide binding]; other site 293614001584 active site 293614001585 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 293614001586 putative nucleic acid binding region [nucleotide binding]; other site 293614001587 G-X-X-G motif; other site 293614001588 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 293614001589 RNA binding site [nucleotide binding]; other site 293614001590 domain interface; other site 293614001591 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 293614001592 16S/18S rRNA binding site [nucleotide binding]; other site 293614001593 S13e-L30e interaction site [polypeptide binding]; other site 293614001594 25S rRNA binding site [nucleotide binding]; other site 293614001595 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01528 293614001596 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 293614001597 RNA binding site [nucleotide binding]; other site 293614001598 active site 293614001599 TLC ATP/ADP transporter; Region: TLC; pfam03219 293614001600 120 KDa Rickettsia surface antigen; Region: 120_Rick_ant; pfam12574 293614001601 Transposase IS200 like; Region: Y1_Tnp; pfam01797 293614001602 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 293614001603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 293614001604 non-specific DNA binding site [nucleotide binding]; other site 293614001605 salt bridge; other site 293614001606 sequence-specific DNA binding site [nucleotide binding]; other site 293614001607 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 293614001608 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 293614001609 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 293614001610 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 293614001611 uncharacterized protein, YfiH family; Region: TIGR00726 293614001612 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 293614001613 active site 293614001614 catalytic residues [active] 293614001615 metal binding site [ion binding]; metal-binding site 293614001616 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 293614001617 pyruvate phosphate dikinase; Provisional; Region: PRK09279 293614001618 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 293614001619 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 293614001620 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 293614001621 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 293614001622 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 293614001623 GSH binding site (G-site) [chemical binding]; other site 293614001624 C-terminal domain interface [polypeptide binding]; other site 293614001625 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 293614001626 N-terminal domain interface [polypeptide binding]; other site 293614001627 dimer interface [polypeptide binding]; other site 293614001628 substrate binding pocket (H-site) [chemical binding]; other site 293614001629 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 293614001630 conserved cys residue [active] 293614001631 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 293614001632 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 293614001633 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 293614001634 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 293614001635 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 293614001636 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 293614001637 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 293614001638 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 293614001639 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 293614001640 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 293614001641 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 293614001642 Predicted membrane protein [Function unknown]; Region: COG5346 293614001643 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 293614001644 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 293614001645 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 293614001646 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 293614001647 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 293614001648 E3 interaction surface; other site 293614001649 lipoyl attachment site [posttranslational modification]; other site 293614001650 e3 binding domain; Region: E3_binding; pfam02817 293614001651 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 293614001652 peptide chain release factor 1; Validated; Region: prfA; PRK00591 293614001653 This domain is found in peptide chain release factors; Region: PCRF; smart00937 293614001654 RF-1 domain; Region: RF-1; pfam00472 293614001655 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 293614001656 DHH family; Region: DHH; pfam01368 293614001657 DHHA1 domain; Region: DHHA1; pfam02272 293614001658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 293614001659 S-adenosylmethionine binding site [chemical binding]; other site 293614001660 Methyltransferase domain; Region: Methyltransf_31; pfam13847 293614001661 transcription termination factor Rho; Provisional; Region: rho; PRK09376 293614001662 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 293614001663 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 293614001664 RNA binding site [nucleotide binding]; other site 293614001665 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 293614001666 multimer interface [polypeptide binding]; other site 293614001667 Walker A motif; other site 293614001668 ATP binding site [chemical binding]; other site 293614001669 Walker B motif; other site 293614001670 Bacterial nucleoid DNA-binding protein [DNA replication, recombination, and repair]; Region: HimA; COG0776 293614001671 IHF - DNA interface [nucleotide binding]; other site 293614001672 IHF dimer interface [polypeptide binding]; other site 293614001673 Protein of unknown function (DUF328); Region: DUF328; cl01143 293614001674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 293614001675 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 293614001676 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 293614001677 domain interfaces; other site 293614001678 active site 293614001679 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 293614001680 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 293614001681 substrate binding pocket [chemical binding]; other site 293614001682 chain length determination region; other site 293614001683 substrate-Mg2+ binding site; other site 293614001684 catalytic residues [active] 293614001685 aspartate-rich region 1; other site 293614001686 active site lid residues [active] 293614001687 aspartate-rich region 2; other site 293614001688 TLC ATP/ADP transporter; Region: TLC; pfam03219 293614001689 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 293614001690 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 293614001691 Ligand binding site; other site 293614001692 metal-binding site 293614001693 AmpG-like permease; Region: 2A0125; TIGR00901 293614001694 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 293614001695 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 293614001696 active site 293614001697 HemY protein N-terminus; Region: HemY_N; pfam07219 293614001698 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 293614001699 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 293614001700 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 293614001701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 293614001702 Protein required for attachment to host cells; Region: Host_attach; cl02398 293614001703 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 293614001704 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 293614001705 putative acyl-acceptor binding pocket; other site 293614001706 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 293614001707 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 293614001708 active site 293614001709 HIGH motif; other site 293614001710 dimer interface [polypeptide binding]; other site 293614001711 KMSKS motif; other site 293614001712 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 293614001713 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 293614001714 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 293614001715 active site 293614001716 arginine:agmatin antiporter; Provisional; Region: PRK10644 293614001717 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 293614001718 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 293614001719 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 293614001720 trimerization site [polypeptide binding]; other site 293614001721 active site 293614001722 cysteine desulfurase; Provisional; Region: PRK14012 293614001723 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 293614001724 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 293614001725 catalytic residue [active] 293614001726 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 293614001727 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 293614001728 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 293614001729 catalytic residue [active] 293614001730 Transcriptional regulator; Region: Rrf2; cl17282 293614001731 Rrf2 family protein; Region: rrf2_super; TIGR00738 293614001732 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00144 293614001733 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 293614001734 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 293614001735 dimer interface [polypeptide binding]; other site 293614001736 allosteric magnesium binding site [ion binding]; other site 293614001737 active site 293614001738 aspartate-rich active site metal binding site; other site 293614001739 Schiff base residues; other site 293614001740 primosome assembly protein PriA; Validated; Region: PRK05580 293614001741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 293614001742 ATP binding site [chemical binding]; other site 293614001743 putative Mg++ binding site [ion binding]; other site 293614001744 helicase superfamily c-terminal domain; Region: HELICc; smart00490 293614001745 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 293614001746 Flavoprotein; Region: Flavoprotein; pfam02441 293614001747 replicative DNA helicase; Provisional; Region: PRK09165 293614001748 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 293614001749 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 293614001750 Walker A motif; other site 293614001751 ATP binding site [chemical binding]; other site 293614001752 Walker B motif; other site 293614001753 DNA binding loops [nucleotide binding] 293614001754 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 293614001755 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 293614001756 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 293614001757 RNA binding surface [nucleotide binding]; other site 293614001758 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 293614001759 active site 293614001760 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 293614001761 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 293614001762 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 293614001763 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 293614001764 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 293614001765 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 293614001766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 293614001767 S-adenosylmethionine binding site [chemical binding]; other site 293614001768 DNA repair protein RadA; Provisional; Region: PRK11823 293614001769 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 293614001770 Walker A motif/ATP binding site; other site 293614001771 ATP binding site [chemical binding]; other site 293614001772 Walker B motif; other site 293614001773 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 293614001774 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 293614001775 Recombination protein O N terminal; Region: RecO_N; pfam11967 293614001776 Recombination protein O C terminal; Region: RecO_C; pfam02565 293614001777 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 293614001778 Glycoprotease family; Region: Peptidase_M22; pfam00814 293614001779 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 293614001780 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 293614001781 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 293614001782 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 293614001783 G1 box; other site 293614001784 putative GEF interaction site [polypeptide binding]; other site 293614001785 GTP/Mg2+ binding site [chemical binding]; other site 293614001786 Switch I region; other site 293614001787 G2 box; other site 293614001788 G3 box; other site 293614001789 Switch II region; other site 293614001790 G4 box; other site 293614001791 G5 box; other site 293614001792 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 293614001793 Translation-initiation factor 2; Region: IF-2; pfam11987 293614001794 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 293614001795 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 293614001796 NusA N-terminal domain; Region: NusA_N; pfam08529 293614001797 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 293614001798 RNA binding site [nucleotide binding]; other site 293614001799 homodimer interface [polypeptide binding]; other site 293614001800 NusA-like KH domain; Region: KH_5; pfam13184 293614001801 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 293614001802 G-X-X-G motif; other site 293614001803 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 293614001804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 293614001805 Sm and related proteins; Region: Sm_like; cl00259 293614001806 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 293614001807 putative oligomer interface [polypeptide binding]; other site 293614001808 putative RNA binding site [nucleotide binding]; other site 293614001809 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 293614001810 DNA binding residues [nucleotide binding] 293614001811 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 293614001812 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 293614001813 RNA binding surface [nucleotide binding]; other site 293614001814 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 293614001815 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 293614001816 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 293614001817 active site 293614001818 HIGH motif; other site 293614001819 dimer interface [polypeptide binding]; other site 293614001820 KMSKS motif; other site 293614001821 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 293614001822 RNA binding surface [nucleotide binding]; other site 293614001823 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 293614001824 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 293614001825 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 293614001826 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 293614001827 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 293614001828 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 293614001829 catalytic site [active] 293614001830 putative active site [active] 293614001831 putative substrate binding site [chemical binding]; other site 293614001832 HRDC domain; Region: HRDC; cl02578 293614001833 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 293614001834 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 293614001835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 293614001836 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 293614001837 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 293614001838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 293614001839 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 293614001840 S-adenosylmethionine binding site [chemical binding]; other site 293614001841 Protein of unknown function (DUF2532); Region: DUF2532; pfam10811 293614001842 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 293614001843 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 293614001844 N-acetyl-D-glucosamine binding site [chemical binding]; other site 293614001845 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 293614001846 hypothetical protein; Validated; Region: PRK00110 293614001847 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 293614001848 Substrate binding site; other site 293614001849 Mg++ binding site; other site 293614001850 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 293614001851 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 293614001852 homotetramer interface [polypeptide binding]; other site 293614001853 FMN binding site [chemical binding]; other site 293614001854 homodimer contacts [polypeptide binding]; other site 293614001855 putative active site [active] 293614001856 putative substrate binding site [chemical binding]; other site 293614001857 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 293614001858 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 293614001859 Putative cyclase; Region: Cyclase; cl00814 293614001860 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 293614001861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 293614001862 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 293614001863 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 293614001864 oligomer interface [polypeptide binding]; other site 293614001865 active site residues [active] 293614001866 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 293614001867 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 293614001868 RNA binding site [nucleotide binding]; other site 293614001869 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 293614001870 RNA binding site [nucleotide binding]; other site 293614001871 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 293614001872 RNA binding site [nucleotide binding]; other site 293614001873 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 293614001874 RNA binding site [nucleotide binding]; other site 293614001875 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 293614001876 RNA binding site [nucleotide binding]; other site 293614001877 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 293614001878 RNA binding site [nucleotide binding]; other site 293614001879 cytidylate kinase; Provisional; Region: cmk; PRK00023 293614001880 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 293614001881 CMP-binding site; other site 293614001882 The sites determining sugar specificity; other site 293614001883 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 293614001884 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 293614001885 Transposase, Mutator family; Region: Transposase_mut; pfam00872 293614001886 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 293614001887 Transposase IS200 like; Region: Y1_Tnp; cl00848 293614001888 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 293614001889 MG2 domain; Region: A2M_N; pfam01835 293614001890 Alpha-2-macroglobulin family; Region: A2M; pfam00207 293614001891 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 293614001892 surface patch; other site 293614001893 thioester region; other site 293614001894 specificity defining residues; other site 293614001895 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 293614001896 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 293614001897 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 293614001898 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 293614001899 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 293614001900 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 293614001901 substrate binding site [chemical binding]; other site 293614001902 oxyanion hole (OAH) forming residues; other site 293614001903 trimer interface [polypeptide binding]; other site 293614001904 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 293614001905 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK06617 293614001906 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 293614001907 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 293614001908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 293614001909 active site 293614001910 phosphorylation site [posttranslational modification] 293614001911 intermolecular recognition site; other site 293614001912 dimerization interface [polypeptide binding]; other site 293614001913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 293614001914 Walker A motif; other site 293614001915 ATP binding site [chemical binding]; other site 293614001916 Walker B motif; other site 293614001917 arginine finger; other site 293614001918 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 293614001919 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 293614001920 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 293614001921 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 293614001922 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 293614001923 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 293614001924 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 293614001925 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 293614001926 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 293614001927 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 293614001928 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 293614001929 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 293614001930 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 293614001931 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 293614001932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 293614001933 S-adenosylmethionine binding site [chemical binding]; other site 293614001934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 293614001935 MraZ protein; Region: MraZ; pfam02381 293614001936 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 293614001937 Na binding site [ion binding]; other site 293614001938 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 293614001939 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 293614001940 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 293614001941 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 293614001942 GIY-YIG motif/motif A; other site 293614001943 active site 293614001944 catalytic site [active] 293614001945 putative DNA binding site [nucleotide binding]; other site 293614001946 metal binding site [ion binding]; metal-binding site 293614001947 UvrB/uvrC motif; Region: UVR; pfam02151 293614001948 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 293614001949 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 293614001950 A new structural DNA glycosylase; Region: AlkD_like; cl11434 293614001951 active site 293614001952 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 293614001953 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 293614001954 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 293614001955 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 293614001956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 293614001957 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 293614001958 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 293614001959 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 293614001960 SEC-C motif; Region: SEC-C; pfam02810 293614001961 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 293614001962 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 293614001963 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 293614001964 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 293614001965 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 293614001966 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 293614001967 hinge; other site 293614001968 active site 293614001969 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 293614001970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 293614001971 Mg2+ binding site [ion binding]; other site 293614001972 G-X-G motif; other site 293614001973 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 293614001974 anchoring element; other site 293614001975 dimer interface [polypeptide binding]; other site 293614001976 ATP binding site [chemical binding]; other site 293614001977 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 293614001978 active site 293614001979 putative metal-binding site [ion binding]; other site 293614001980 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 293614001981 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 293614001982 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 293614001983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 293614001984 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 293614001985 MgtE intracellular N domain; Region: MgtE_N; pfam03448 293614001986 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 293614001987 Divalent cation transporter; Region: MgtE; pfam01769 293614001988 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 293614001989 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 293614001990 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 293614001991 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 293614001992 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 293614001993 Cu(I) binding site [ion binding]; other site 293614001994 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 293614001995 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 293614001996 dimer interface [polypeptide binding]; other site 293614001997 substrate binding site [chemical binding]; other site 293614001998 metal binding sites [ion binding]; metal-binding site 293614001999 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 293614002000 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 293614002001 TraX protein; Region: TraX; pfam05857 293614002002 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 293614002003 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 293614002004 ssDNA binding site; other site 293614002005 generic binding surface II; other site 293614002006 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 293614002007 ATP binding site [chemical binding]; other site 293614002008 putative Mg++ binding site [ion binding]; other site 293614002009 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 293614002010 nucleotide binding region [chemical binding]; other site 293614002011 ATP-binding site [chemical binding]; other site 293614002012 Coenzyme A transferase; Region: CoA_trans; cl17247 293614002013 Coenzyme A transferase; Region: CoA_trans; cl17247 293614002014 Coenzyme A transferase; Region: CoA_trans; cl17247 293614002015 V-type ATP synthase subunit I; Validated; Region: PRK05771 293614002016 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 293614002017 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 293614002018 Mg++ binding site [ion binding]; other site 293614002019 putative catalytic motif [active] 293614002020 putative substrate binding site [chemical binding]; other site 293614002021 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 293614002022 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 293614002023 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 293614002024 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 293614002025 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 293614002026 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 293614002027 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 293614002028 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 293614002029 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 293614002030 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 293614002031 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 293614002032 ATP binding site [chemical binding]; other site 293614002033 putative Mg++ binding site [ion binding]; other site 293614002034 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 293614002035 nucleotide binding region [chemical binding]; other site 293614002036 ATP-binding site [chemical binding]; other site 293614002037 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 293614002038 Uncharacterized conserved protein [Function unknown]; Region: COG2938 293614002039 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 293614002040 active site residue [active] 293614002041 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 293614002042 DnaA N-terminal domain; Region: DnaA_N; pfam11638 293614002043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 293614002044 Walker A motif; other site 293614002045 ATP binding site [chemical binding]; other site 293614002046 Walker B motif; other site 293614002047 arginine finger; other site 293614002048 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 293614002049 DnaA box-binding interface [nucleotide binding]; other site 293614002050 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 293614002051 active site 293614002052 nucleophile elbow; other site 293614002053 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 293614002054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 293614002055 putative substrate translocation pore; other site 293614002056 GTP-binding protein YchF; Reviewed; Region: PRK09601 293614002057 YchF GTPase; Region: YchF; cd01900 293614002058 G1 box; other site 293614002059 GTP/Mg2+ binding site [chemical binding]; other site 293614002060 Switch I region; other site 293614002061 G2 box; other site 293614002062 Switch II region; other site 293614002063 G3 box; other site 293614002064 G4 box; other site 293614002065 G5 box; other site 293614002066 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 293614002067 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 293614002068 putative active site [active] 293614002069 catalytic residue [active] 293614002070 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 293614002071 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 293614002072 5S rRNA interface [nucleotide binding]; other site 293614002073 CTC domain interface [polypeptide binding]; other site 293614002074 L16 interface [polypeptide binding]; other site 293614002075 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 293614002076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 293614002077 FeS/SAM binding site; other site 293614002078 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 293614002079 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 293614002080 23S rRNA binding site [nucleotide binding]; other site 293614002081 L21 binding site [polypeptide binding]; other site 293614002082 L13 binding site [polypeptide binding]; other site 293614002083 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 293614002084 ribonuclease P; Reviewed; Region: rnpA; PRK01492 293614002085 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 293614002086 Phosphotransferase enzyme family; Region: APH; pfam01636 293614002087 active site 293614002088 ATP binding site [chemical binding]; other site 293614002089 substrate binding site [chemical binding]; other site 293614002090 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 293614002091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 293614002092 dimerization interface [polypeptide binding]; other site 293614002093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 293614002094 dimer interface [polypeptide binding]; other site 293614002095 phosphorylation site [posttranslational modification] 293614002096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 293614002097 ATP binding site [chemical binding]; other site 293614002098 Mg2+ binding site [ion binding]; other site 293614002099 G-X-G motif; other site 293614002100 Ribosomal protein S21 [Translation, ribosomal structure and biogenesis]; Region: RpsU; COG0828 293614002101 Uncharacterized conserved protein [Function unknown]; Region: COG5590 293614002102 COQ9; Region: COQ9; pfam08511 293614002103 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 293614002104 putative active site [active] 293614002105 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 293614002106 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 293614002107 HIGH motif; other site 293614002108 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 293614002109 active site 293614002110 KMSKS motif; other site 293614002111 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 293614002112 tRNA binding surface [nucleotide binding]; other site 293614002113 anticodon binding site; other site 293614002114 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 293614002115 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 293614002116 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 293614002117 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 293614002118 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 293614002119 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 293614002120 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 293614002121 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 293614002122 carboxyltransferase (CT) interaction site; other site 293614002123 biotinylation site [posttranslational modification]; other site 293614002124 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 293614002125 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 293614002126 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 293614002127 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 293614002128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 293614002129 putative substrate translocation pore; other site 293614002130 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 293614002131 putative acyl-acceptor binding pocket; other site 293614002132 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 293614002133 acyl-activating enzyme (AAE) consensus motif; other site 293614002134 putative AMP binding site [chemical binding]; other site 293614002135 TfoX N-terminal domain; Region: TfoX_N; pfam04993 293614002136 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 293614002137 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 293614002138 ABC-ATPase subunit interface; other site 293614002139 dimer interface [polypeptide binding]; other site 293614002140 putative PBP binding regions; other site 293614002141 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 293614002142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 293614002143 S-adenosylmethionine binding site [chemical binding]; other site 293614002144 glutamyl-tRNA synthetase; Provisional; Region: gltX; PRK14895 293614002145 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 293614002146 HIGH motif; other site 293614002147 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 293614002148 active site 293614002149 KMSKS motif; other site 293614002150 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 293614002151 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 293614002152 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 293614002153 synthetase active site [active] 293614002154 metal binding site [ion binding]; metal-binding site 293614002155 NTP binding site [chemical binding]; other site 293614002156 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 293614002157 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 293614002158 ring oligomerisation interface [polypeptide binding]; other site 293614002159 ATP/Mg binding site [chemical binding]; other site 293614002160 stacking interactions; other site 293614002161 hinge regions; other site 293614002162 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 293614002163 oligomerisation interface [polypeptide binding]; other site 293614002164 mobile loop; other site 293614002165 roof hairpin; other site 293614002166 ribonuclease PH; Reviewed; Region: rph; PRK00173 293614002167 Ribonuclease PH; Region: RNase_PH_bact; cd11362 293614002168 hexamer interface [polypeptide binding]; other site 293614002169 active site 293614002170 GrpE; Region: GrpE; pfam01025 293614002171 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 293614002172 dimer interface [polypeptide binding]; other site 293614002173 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 293614002174 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 293614002175 Domain of unknown function DUF20; Region: UPF0118; pfam01594 293614002176 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 293614002177 hypothetical protein; Validated; Region: PRK06620 293614002178 metabolite-proton symporter; Region: 2A0106; TIGR00883 293614002179 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 293614002180 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 293614002181 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 293614002182 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 293614002183 alphaNTD - beta interaction site [polypeptide binding]; other site 293614002184 alphaNTD homodimer interface [polypeptide binding]; other site 293614002185 alphaNTD - beta' interaction site [polypeptide binding]; other site 293614002186 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 293614002187 30S ribosomal protein S11; Validated; Region: PRK05309 293614002188 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 293614002189 30S ribosomal protein S13; Region: bact_S13; TIGR03631 293614002190 adenylate kinase; Reviewed; Region: adk; PRK00279 293614002191 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 293614002192 AMP-binding site [chemical binding]; other site 293614002193 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 293614002194 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 293614002195 SecY translocase; Region: SecY; pfam00344 293614002196 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 293614002197 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 293614002198 23S rRNA binding site [nucleotide binding]; other site 293614002199 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 293614002200 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 293614002201 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 293614002202 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 293614002203 5S rRNA interface [nucleotide binding]; other site 293614002204 23S rRNA interface [nucleotide binding]; other site 293614002205 L5 interface [polypeptide binding]; other site 293614002206 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 293614002207 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 293614002208 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 293614002209 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 293614002210 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 293614002211 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 293614002212 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 293614002213 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 293614002214 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 293614002215 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 293614002216 RNA binding site [nucleotide binding]; other site 293614002217 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 293614002218 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 293614002219 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 293614002220 L23 interface [polypeptide binding]; other site 293614002221 trigger factor interaction site; other site 293614002222 23S rRNA interface [nucleotide binding]; other site 293614002223 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 293614002224 23S rRNA interface [nucleotide binding]; other site 293614002225 5S rRNA interface [nucleotide binding]; other site 293614002226 putative antibiotic binding site [chemical binding]; other site 293614002227 L25 interface [polypeptide binding]; other site 293614002228 L27 interface [polypeptide binding]; other site 293614002229 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 293614002230 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 293614002231 G-X-X-G motif; other site 293614002232 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 293614002233 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 293614002234 putative translocon binding site; other site 293614002235 protein-rRNA interface [nucleotide binding]; other site 293614002236 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 293614002237 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 293614002238 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 293614002239 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 293614002240 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 293614002241 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 293614002242 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 293614002243 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 293614002244 elongation factor Tu; Reviewed; Region: PRK00049 293614002245 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 293614002246 G1 box; other site 293614002247 GEF interaction site [polypeptide binding]; other site 293614002248 GTP/Mg2+ binding site [chemical binding]; other site 293614002249 Switch I region; other site 293614002250 G2 box; other site 293614002251 G3 box; other site 293614002252 Switch II region; other site 293614002253 G4 box; other site 293614002254 G5 box; other site 293614002255 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 293614002256 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 293614002257 Antibiotic Binding Site [chemical binding]; other site 293614002258 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 293614002259 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 293614002260 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 293614002261 fumarate hydratase; Reviewed; Region: fumC; PRK00485 293614002262 Class II fumarases; Region: Fumarase_classII; cd01362 293614002263 active site 293614002264 tetramer interface [polypeptide binding]; other site 293614002265 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 293614002266 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 293614002267 putative active site [active] 293614002268 cell division protein FtsZ; Validated; Region: PRK09330 293614002269 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 293614002270 nucleotide binding site [chemical binding]; other site 293614002271 SulA interaction site; other site 293614002272 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cl00178 293614002273 primary substrate binding site; other site 293614002274 inhibition loop; other site 293614002275 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 293614002276 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 293614002277 muropeptide transporter; Validated; Region: ampG; cl17669 293614002278 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 293614002279 DEAD-like helicases superfamily; Region: DEXDc; smart00487 293614002280 ATP binding site [chemical binding]; other site 293614002281 Mg++ binding site [ion binding]; other site 293614002282 motif III; other site 293614002283 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 293614002284 nucleotide binding region [chemical binding]; other site 293614002285 ATP-binding site [chemical binding]; other site 293614002286 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 293614002287 DNA-binding site [nucleotide binding]; DNA binding site 293614002288 RNA-binding motif; other site 293614002289 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 293614002290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 293614002291 S-adenosylmethionine binding site [chemical binding]; other site 293614002292 SurA N-terminal domain; Region: SurA_N_3; cl07813 293614002293 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 293614002294 Organic solvent tolerance protein; Region: OstA_C; pfam04453 293614002295 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 293614002296 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 293614002297 generic binding surface II; other site 293614002298 generic binding surface I; other site 293614002299 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 293614002300 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 293614002301 substrate binding pocket [chemical binding]; other site 293614002302 membrane-bound complex binding site; other site 293614002303 hinge residues; other site 293614002304 Predicted membrane protein [Function unknown]; Region: COG2860 293614002305 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 293614002306 putative catalytic site [active] 293614002307 putative phosphate binding site [ion binding]; other site 293614002308 active site 293614002309 metal binding site A [ion binding]; metal-binding site 293614002310 DNA binding site [nucleotide binding] 293614002311 putative AP binding site [nucleotide binding]; other site 293614002312 putative metal binding site B [ion binding]; other site 293614002313 Uncharacterized conserved protein [Function unknown]; Region: COG4095 293614002314 GTP-binding protein Der; Reviewed; Region: PRK00093 293614002315 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 293614002316 G1 box; other site 293614002317 GTP/Mg2+ binding site [chemical binding]; other site 293614002318 Switch I region; other site 293614002319 G2 box; other site 293614002320 Switch II region; other site 293614002321 G3 box; other site 293614002322 G4 box; other site 293614002323 G5 box; other site 293614002324 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 293614002325 G1 box; other site 293614002326 GTP/Mg2+ binding site [chemical binding]; other site 293614002327 Switch I region; other site 293614002328 G2 box; other site 293614002329 G3 box; other site 293614002330 Switch II region; other site 293614002331 G4 box; other site 293614002332 G5 box; other site 293614002333 AAA domain; Region: AAA_14; pfam13173 293614002334 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 293614002335 ABC1 family; Region: ABC1; pfam03109 293614002336 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 293614002337 active site 293614002338 ATP binding site [chemical binding]; other site 293614002339 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 293614002340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 293614002341 S-adenosylmethionine binding site [chemical binding]; other site 293614002342 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 293614002343 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 293614002344 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 293614002345 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 293614002346 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 293614002347 Protein of unknown function (DUF511); Region: DUF511; cl01114 293614002348 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 293614002349 active site 293614002350 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 293614002351 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 293614002352 HIGH motif; other site 293614002353 active site 293614002354 KMSKS motif; other site 293614002355 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 293614002356 tRNA binding surface [nucleotide binding]; other site 293614002357 anticodon binding site; other site 293614002358 thymidylate kinase; Validated; Region: tmk; PRK00698 293614002359 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 293614002360 TMP-binding site; other site 293614002361 ATP-binding site [chemical binding]; other site 293614002362 metabolite-proton symporter; Region: 2A0106; TIGR00883 293614002363 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 293614002364 UbiA prenyltransferase family; Region: UbiA; pfam01040 293614002365 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 293614002366 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 293614002367 active site 293614002368 HIGH motif; other site 293614002369 nucleotide binding site [chemical binding]; other site 293614002370 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 293614002371 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 293614002372 active site 293614002373 KMSKS motif; other site 293614002374 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 293614002375 tRNA binding surface [nucleotide binding]; other site 293614002376 anticodon binding site; other site 293614002377 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 293614002378 RmuC family; Region: RmuC; pfam02646 293614002379 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 293614002380 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 293614002381 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 293614002382 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 293614002383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 293614002384 Walker A motif; other site 293614002385 ATP binding site [chemical binding]; other site 293614002386 Walker B motif; other site 293614002387 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 293614002388 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 293614002389 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 293614002390 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 293614002391 Ligand Binding Site [chemical binding]; other site 293614002392 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 293614002393 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 293614002394 YcfA-like protein; Region: YcfA; cl00752 293614002395 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 293614002396 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 293614002397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 293614002398 Walker A/P-loop; other site 293614002399 ATP binding site [chemical binding]; other site 293614002400 Q-loop/lid; other site 293614002401 ABC transporter signature motif; other site 293614002402 Walker B; other site 293614002403 D-loop; other site 293614002404 H-loop/switch region; other site 293614002405 Protein of unknown function (DUF2673); Region: DUF2673; pfam10880 293614002406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 293614002407 putative substrate translocation pore; other site 293614002408 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 293614002409 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 293614002410 FtsX-like permease family; Region: FtsX; pfam02687 293614002411 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 293614002412 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 293614002413 Walker A/P-loop; other site 293614002414 ATP binding site [chemical binding]; other site 293614002415 Q-loop/lid; other site 293614002416 ABC transporter signature motif; other site 293614002417 Walker B; other site 293614002418 D-loop; other site 293614002419 H-loop/switch region; other site 293614002420 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 293614002421 Domain of unknown function DUF21; Region: DUF21; pfam01595 293614002422 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 293614002423 Transporter associated domain; Region: CorC_HlyC; smart01091 293614002424 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 293614002425 Rickettsia outer membrane protein B; Region: rOmpB; pfam12334 293614002426 Autotransporter beta-domain; Region: Autotransporter; smart00869 293614002427 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 293614002428 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 293614002429 synthetase active site [active] 293614002430 NTP binding site [chemical binding]; other site 293614002431 metal binding site [ion binding]; metal-binding site 293614002432 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 293614002433 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 293614002434 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 293614002435 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 293614002436 DNA binding residues [nucleotide binding] 293614002437 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 293614002438 IHF dimer interface [polypeptide binding]; other site 293614002439 IHF - DNA interface [nucleotide binding]; other site 293614002440 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 293614002441 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 293614002442 catalytic triad [active] 293614002443 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 293614002444 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 293614002445 putative acyl-acceptor binding pocket; other site 293614002446 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 293614002447 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 293614002448 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 293614002449 Peptidase family M23; Region: Peptidase_M23; pfam01551 293614002450 Protein of unknown function (DUF519); Region: DUF519; pfam04378 293614002451 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 293614002452 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 293614002453 nucleotide binding pocket [chemical binding]; other site 293614002454 K-X-D-G motif; other site 293614002455 catalytic site [active] 293614002456 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 293614002457 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 293614002458 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 293614002459 Dimer interface [polypeptide binding]; other site 293614002460 BRCT sequence motif; other site 293614002461 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 293614002462 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 293614002463 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 293614002464 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 293614002465 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 293614002466 Adenovirus IVa2 protein; Region: Adeno_IVa2; pfam02456 293614002467 trmE is a tRNA modification GTPase; Region: trmE; cd04164 293614002468 G1 box; other site 293614002469 GTP/Mg2+ binding site [chemical binding]; other site 293614002470 Switch I region; other site 293614002471 G2 box; other site 293614002472 Switch II region; other site 293614002473 G3 box; other site 293614002474 G4 box; other site 293614002475 G5 box; other site 293614002476 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 293614002477 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 293614002478 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 293614002479 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 293614002480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 293614002481 metabolite-proton symporter; Region: 2A0106; TIGR00883 293614002482 putative substrate translocation pore; other site 293614002483 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 293614002484 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 293614002485 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 293614002486 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 293614002487 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 293614002488 aspartate kinase; Reviewed; Region: PRK06635 293614002489 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 293614002490 putative nucleotide binding site [chemical binding]; other site 293614002491 putative catalytic residues [active] 293614002492 putative Mg ion binding site [ion binding]; other site 293614002493 putative aspartate binding site [chemical binding]; other site 293614002494 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 293614002495 putative allosteric regulatory residue; other site 293614002496 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 293614002497 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 293614002498 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 293614002499 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 293614002500 tetramer interfaces [polypeptide binding]; other site 293614002501 binuclear metal-binding site [ion binding]; other site 293614002502 twin arginine translocase protein A; Provisional; Region: tatA; PRK01470 293614002503 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 293614002504 putative ligand binding site [chemical binding]; other site 293614002505 Predicted methyltransferases [General function prediction only]; Region: COG0313 293614002506 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 293614002507 putative SAM binding site [chemical binding]; other site 293614002508 putative homodimer interface [polypeptide binding]; other site 293614002509 Predicted small secreted protein [Function unknown]; Region: COG5510 293614002510 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 293614002511 endonuclease III; Region: ENDO3c; smart00478 293614002512 minor groove reading motif; other site 293614002513 helix-hairpin-helix signature motif; other site 293614002514 substrate binding pocket [chemical binding]; other site 293614002515 active site 293614002516 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 293614002517 putative GSH binding site [chemical binding]; other site 293614002518 catalytic residues [active] 293614002519 putative hydrolase; Provisional; Region: PRK11460 293614002520 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 293614002521 DNA methylase; Region: N6_N4_Mtase; cl17433 293614002522 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 293614002523 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 293614002524 dimer interface [polypeptide binding]; other site 293614002525 active site 293614002526 glycine-pyridoxal phosphate binding site [chemical binding]; other site 293614002527 folate binding site [chemical binding]; other site 293614002528 lipoyl synthase; Provisional; Region: PRK05481 293614002529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 293614002530 FeS/SAM binding site; other site 293614002531 PemK-like protein; Region: PemK; pfam02452 293614002532 metal-binding heat shock protein; Provisional; Region: PRK00016 293614002533 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 293614002534 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 293614002535 Transporter associated domain; Region: CorC_HlyC; smart01091 293614002536 Transposase IS200 like; Region: Y1_Tnp; cl00848 293614002537 TLC ATP/ADP transporter; Region: TLC; pfam03219 293614002538 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 293614002539 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 293614002540 acetyl-CoA acetyltransferase; Provisional; Region: PRK06633 293614002541 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 293614002542 dimer interface [polypeptide binding]; other site 293614002543 active site 293614002544 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 293614002545 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 293614002546 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 293614002547 Part of AAA domain; Region: AAA_19; pfam13245 293614002548 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 293614002549 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 293614002550 Family description; Region: UvrD_C_2; pfam13538 293614002551 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 293614002552 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 293614002553 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 293614002554 active site 293614002555 catalytic site [active] 293614002556 substrate binding site [chemical binding]; other site 293614002557 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 293614002558 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 293614002559 CoA-binding site [chemical binding]; other site 293614002560 ATP-binding [chemical binding]; other site 293614002561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 293614002562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 293614002563 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 293614002564 RNA/DNA hybrid binding site [nucleotide binding]; other site 293614002565 active site 293614002566 hypothetical protein; Provisional; Region: PRK06630 293614002567 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 293614002568 mce related protein; Region: MCE; pfam02470 293614002569 HD domain; Region: HD_4; pfam13328 293614002570 HD domain; Region: HD_4; pfam13328 293614002571 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 293614002572 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 293614002573 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 293614002574 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 293614002575 hexamer interface [polypeptide binding]; other site 293614002576 Walker A motif; other site 293614002577 ATP binding site [chemical binding]; other site 293614002578 Walker B motif; other site 293614002579 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 293614002580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 293614002581 NAD(P) binding site [chemical binding]; other site 293614002582 active site 293614002583 acyl carrier protein; Provisional; Region: acpP; PRK00982 293614002584 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 293614002585 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 293614002586 dimer interface [polypeptide binding]; other site 293614002587 active site 293614002588 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 293614002589 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 293614002590 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 293614002591 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 293614002592 catalytic site [active] 293614002593 G-X2-G-X-G-K; other site 293614002594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 293614002595 sequence-specific DNA binding site [nucleotide binding]; other site 293614002596 salt bridge; other site 293614002597 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 293614002598 rod shape-determining protein MreC; Region: MreC; pfam04085 293614002599 rod shape-determining protein MreB; Provisional; Region: PRK13927 293614002600 MreB and similar proteins; Region: MreB_like; cd10225 293614002601 nucleotide binding site [chemical binding]; other site 293614002602 Mg binding site [ion binding]; other site 293614002603 putative protofilament interaction site [polypeptide binding]; other site 293614002604 RodZ interaction site [polypeptide binding]; other site 293614002605 Predicted permeases [General function prediction only]; Region: COG0795 293614002606 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 293614002607 putative outer membrane lipoprotein; Provisional; Region: PRK09967 293614002608 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 293614002609 ligand binding site [chemical binding]; other site 293614002610 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 293614002611 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 293614002612 dimer interface [polypeptide binding]; other site 293614002613 active site 293614002614 CoA binding pocket [chemical binding]; other site 293614002615 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 293614002616 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 293614002617 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 293614002618 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 293614002619 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 293614002620 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 293614002621 P loop; other site 293614002622 GTP binding site [chemical binding]; other site 293614002623 DNA polymerase I; Provisional; Region: PRK05755 293614002624 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 293614002625 active site 293614002626 metal binding site 1 [ion binding]; metal-binding site 293614002627 putative 5' ssDNA interaction site; other site 293614002628 metal binding site 3; metal-binding site 293614002629 metal binding site 2 [ion binding]; metal-binding site 293614002630 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 293614002631 putative DNA binding site [nucleotide binding]; other site 293614002632 putative metal binding site [ion binding]; other site 293614002633 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 293614002634 active site 293614002635 substrate binding site [chemical binding]; other site 293614002636 catalytic site [active] 293614002637 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 293614002638 active site 293614002639 DNA binding site [nucleotide binding] 293614002640 catalytic site [active] 293614002641 S-adenosylmethionine synthetase; Validated; Region: PRK05250 293614002642 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 293614002643 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 293614002644 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 293614002645 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 293614002646 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 293614002647 putative active site [active] 293614002648 putative PHP Thumb interface [polypeptide binding]; other site 293614002649 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 293614002650 generic binding surface I; other site 293614002651 generic binding surface II; other site 293614002652 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 293614002653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 293614002654 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 293614002655 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 293614002656 Protein of unknown function; Region: DUF3971; pfam13116 293614002657 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 293614002658 muropeptide transporter; Validated; Region: ampG; cl17669 293614002659 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 293614002660 seryl-tRNA synthetase; Provisional; Region: PRK05431 293614002661 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 293614002662 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 293614002663 dimer interface [polypeptide binding]; other site 293614002664 active site 293614002665 motif 1; other site 293614002666 motif 2; other site 293614002667 motif 3; other site 293614002668 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 293614002669 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 293614002670 Integral membrane protein TerC family; Region: TerC; cl10468 293614002671 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 293614002672 Methyltransferase domain; Region: Methyltransf_31; pfam13847 293614002673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 293614002674 S-adenosylmethionine binding site [chemical binding]; other site 293614002675 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 293614002676 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 293614002677 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 293614002678 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 293614002679 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 293614002680 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 293614002681 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 293614002682 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 293614002683 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 293614002684 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 293614002685 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13541 293614002686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 293614002687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 293614002688 Walker A/P-loop; other site 293614002689 Walker A/P-loop; other site 293614002690 ATP binding site [chemical binding]; other site 293614002691 ATP binding site [chemical binding]; other site 293614002692 Q-loop/lid; other site 293614002693 ABC transporter signature motif; other site 293614002694 Walker B; other site 293614002695 D-loop; other site 293614002696 H-loop/switch region; other site 293614002697 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 293614002698 4Fe-4S binding domain; Region: Fer4; cl02805 293614002699 4Fe-4S binding domain; Region: Fer4; pfam00037 293614002700 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 293614002701 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 293614002702 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 293614002703 NADH dehydrogenase subunit G; Validated; Region: PRK09130 293614002704 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 293614002705 catalytic loop [active] 293614002706 iron binding site [ion binding]; other site 293614002707 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 293614002708 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 293614002709 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 293614002710 Predicted membrane protein [Function unknown]; Region: COG3671 293614002711 aconitate hydratase; Validated; Region: PRK09277 293614002712 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 293614002713 substrate binding site [chemical binding]; other site 293614002714 ligand binding site [chemical binding]; other site 293614002715 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 293614002716 substrate binding site [chemical binding]; other site 293614002717 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK01474 293614002718 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 293614002719 gamma subunit interface [polypeptide binding]; other site 293614002720 epsilon subunit interface [polypeptide binding]; other site 293614002721 LBP interface [polypeptide binding]; other site 293614002722 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 293614002723 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 293614002724 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 293614002725 alpha subunit interaction interface [polypeptide binding]; other site 293614002726 Walker A motif; other site 293614002727 ATP binding site [chemical binding]; other site 293614002728 Walker B motif; other site 293614002729 inhibitor binding site; inhibition site 293614002730 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 293614002731 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 293614002732 core domain interface [polypeptide binding]; other site 293614002733 delta subunit interface [polypeptide binding]; other site 293614002734 epsilon subunit interface [polypeptide binding]; other site 293614002735 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 293614002736 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 293614002737 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 293614002738 beta subunit interaction interface [polypeptide binding]; other site 293614002739 Walker A motif; other site 293614002740 ATP binding site [chemical binding]; other site 293614002741 Walker B motif; other site 293614002742 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 293614002743 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 293614002744 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 293614002745 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 293614002746 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 293614002747 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 293614002748 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 293614002749 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 293614002750 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 293614002751 dimerization interface [polypeptide binding]; other site 293614002752 DPS ferroxidase diiron center [ion binding]; other site 293614002753 ion pore; other site 293614002754 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 293614002755 Transglycosylase; Region: Transgly; pfam00912 293614002756 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 293614002757 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 293614002758 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 293614002759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 293614002760 FeS/SAM binding site; other site 293614002761 TRAM domain; Region: TRAM; pfam01938 293614002762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 293614002763 Bacterial SH3 domain; Region: SH3_4; pfam06347 293614002764 Bacterial SH3 domain; Region: SH3_4; pfam06347 293614002765 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 293614002766 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 293614002767 TrkA-N domain; Region: TrkA_N; pfam02254 293614002768 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 293614002769 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 293614002770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 293614002771 non-specific DNA binding site [nucleotide binding]; other site 293614002772 salt bridge; other site 293614002773 sequence-specific DNA binding site [nucleotide binding]; other site 293614002774 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 293614002775 rRNA binding site [nucleotide binding]; other site 293614002776 predicted 30S ribosome binding site; other site 293614002777 Maf-like protein; Region: Maf; pfam02545 293614002778 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 293614002779 active site 293614002780 dimer interface [polypeptide binding]; other site 293614002781 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 293614002782 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 293614002783 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 293614002784 active site 293614002785 DNA binding site [nucleotide binding] 293614002786 Int/Topo IB signature motif; other site 293614002787 Phasin protein; Region: Phasin_2; pfam09361 293614002788 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 293614002789 PLD-like domain; Region: PLDc_2; pfam13091 293614002790 putative active site [active] 293614002791 catalytic site [active] 293614002792 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 293614002793 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 293614002794 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 293614002795 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 293614002796 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 293614002797 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 293614002798 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 293614002799 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 293614002800 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 293614002801 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 293614002802 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 293614002803 active site 293614002804 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 293614002805 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 293614002806 Mg++ binding site [ion binding]; other site 293614002807 putative catalytic motif [active] 293614002808 putative substrate binding site [chemical binding]; other site 293614002809 Protein of unknown function (DUF721); Region: DUF721; pfam05258 293614002810 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 293614002811 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 293614002812 Ferredoxin [Energy production and conversion]; Region: COG1146 293614002813 4Fe-4S binding domain; Region: Fer4; cl02805 293614002814 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 293614002815 heme exporter protein CcmC; Region: ccmC; TIGR01191 293614002816 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 293614002817 nucleoside/Zn binding site; other site 293614002818 dimer interface [polypeptide binding]; other site 293614002819 catalytic motif [active] 293614002820 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 293614002821 Cation efflux family; Region: Cation_efflux; cl00316 293614002822 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 293614002823 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 293614002824 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 293614002825 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 293614002826 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 293614002827 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 293614002828 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 293614002829 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 293614002830 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 293614002831 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 293614002832 dimer interface [polypeptide binding]; other site 293614002833 ssDNA binding site [nucleotide binding]; other site 293614002834 tetramer (dimer of dimers) interface [polypeptide binding]; other site 293614002835 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 293614002836 metabolite-proton symporter; Region: 2A0106; TIGR00883 293614002837 hypothetical protein; Reviewed; Region: PRK01530 293614002838 heat shock protein 90; Provisional; Region: PRK05218 293614002839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 293614002840 ATP binding site [chemical binding]; other site 293614002841 Mg2+ binding site [ion binding]; other site 293614002842 G-X-G motif; other site 293614002843 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 293614002844 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 293614002845 substrate-cofactor binding pocket; other site 293614002846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 293614002847 catalytic residue [active] 293614002848 trigger factor; Provisional; Region: tig; PRK01490 293614002849 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 293614002850 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 293614002851 GTPase CgtA; Reviewed; Region: obgE; PRK12299 293614002852 GTP1/OBG; Region: GTP1_OBG; pfam01018 293614002853 Obg GTPase; Region: Obg; cd01898 293614002854 G1 box; other site 293614002855 GTP/Mg2+ binding site [chemical binding]; other site 293614002856 Switch I region; other site 293614002857 G2 box; other site 293614002858 G3 box; other site 293614002859 Switch II region; other site 293614002860 G4 box; other site 293614002861 G5 box; other site 293614002862 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 293614002863 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 293614002864 dimer interface [polypeptide binding]; other site 293614002865 active site 293614002866 citrylCoA binding site [chemical binding]; other site 293614002867 NADH binding [chemical binding]; other site 293614002868 cationic pore residues; other site 293614002869 oxalacetate/citrate binding site [chemical binding]; other site 293614002870 coenzyme A binding site [chemical binding]; other site 293614002871 catalytic triad [active] 293614002872 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 293614002873 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 293614002874 Fe-S cluster binding site [ion binding]; other site 293614002875 active site 293614002876 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 293614002877 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 293614002878 RNA binding surface [nucleotide binding]; other site 293614002879 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 293614002880 active site 293614002881 PemK-like protein; Region: PemK; pfam02452 293614002882 bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed; Region: PRK01544 293614002883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 293614002884 S-adenosylmethionine binding site [chemical binding]; other site 293614002885 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 293614002886 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 293614002887 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 293614002888 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 293614002889 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 293614002890 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 293614002891 motif 1; other site 293614002892 dimer interface [polypeptide binding]; other site 293614002893 active site 293614002894 motif 2; other site 293614002895 motif 3; other site 293614002896 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 293614002897 putative active site [active] 293614002898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 293614002899 metabolite-proton symporter; Region: 2A0106; TIGR00883 293614002900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 293614002901 putative substrate translocation pore; other site 293614002902 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 293614002903 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 293614002904 motif 1; other site 293614002905 active site 293614002906 motif 2; other site 293614002907 motif 3; other site 293614002908 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 293614002909 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 293614002910 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 293614002911 dimerization interface 3.5A [polypeptide binding]; other site 293614002912 active site 293614002913 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 293614002914 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 293614002915 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 293614002916 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 293614002917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 293614002918 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 293614002919 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 293614002920 DNA binding residues [nucleotide binding] 293614002921 DNA primase, catalytic core; Region: dnaG; TIGR01391 293614002922 CHC2 zinc finger; Region: zf-CHC2; pfam01807 293614002923 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 293614002924 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 293614002925 active site 293614002926 metal binding site [ion binding]; metal-binding site 293614002927 interdomain interaction site; other site 293614002928 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 293614002929 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 293614002930 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 293614002931 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 293614002932 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 293614002933 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 293614002934 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 293614002935 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 293614002936 ligand binding site [chemical binding]; other site 293614002937 homodimer interface [polypeptide binding]; other site 293614002938 NAD(P) binding site [chemical binding]; other site 293614002939 trimer interface B [polypeptide binding]; other site 293614002940 trimer interface A [polypeptide binding]; other site 293614002941 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 293614002942 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 293614002943 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06645 293614002944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 293614002945 Walker A motif; other site 293614002946 ATP binding site [chemical binding]; other site 293614002947 Walker B motif; other site 293614002948 arginine finger; other site 293614002949 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 293614002950 hypothetical protein; Validated; Region: PRK00153 293614002951 Predicted aspartyl protease [General function prediction only]; Region: COG3577 293614002952 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 293614002953 catalytic motif [active] 293614002954 Catalytic residue [active] 293614002955 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 293614002956 Beta-lactamase; Region: Beta-lactamase; pfam00144 293614002957 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 293614002958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 293614002959 Walker A/P-loop; other site 293614002960 ATP binding site [chemical binding]; other site 293614002961 Q-loop/lid; other site 293614002962 ABC transporter signature motif; other site 293614002963 Walker B; other site 293614002964 D-loop; other site 293614002965 H-loop/switch region; other site 293614002966 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 293614002967 putative hydrolase; Provisional; Region: PRK02113 293614002968 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 293614002969 active site 293614002970 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 293614002971 Predicted permeases [General function prediction only]; Region: COG0795 293614002972 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 293614002973 DNA polymerase III subunit chi; Provisional; Region: PRK06646 293614002974 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 293614002975 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 293614002976 metal binding site [ion binding]; metal-binding site 293614002977 dimer interface [polypeptide binding]; other site 293614002978 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 293614002979 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 293614002980 Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004 293614002981 Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004 293614002982 Uncharacterized conserved protein [Function unknown]; Region: COG1434 293614002983 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 293614002984 putative active site [active] 293614002985 lipoate-protein ligase B; Provisional; Region: PRK14347 293614002986 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 293614002987 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 293614002988 amidase catalytic site [active] 293614002989 Zn binding residues [ion binding]; other site 293614002990 substrate binding site [chemical binding]; other site 293614002991 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 293614002992 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 293614002993 ribosomal protein L33, bacterial type; Region: rpmG_bact; TIGR01023 293614002994 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 293614002995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 293614002996 ATP binding site [chemical binding]; other site 293614002997 Mg2+ binding site [ion binding]; other site 293614002998 G-X-G motif; other site 293614002999 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 293614003000 ATP binding site [chemical binding]; other site 293614003001 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 293614003002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 293614003003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 293614003004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 293614003005 metabolite-proton symporter; Region: 2A0106; TIGR00883 293614003006 putative substrate translocation pore; other site 293614003007 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 293614003008 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 293614003009 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 293614003010 ferrochelatase; Reviewed; Region: hemH; PRK00035 293614003011 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 293614003012 C-terminal domain interface [polypeptide binding]; other site 293614003013 active site 293614003014 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 293614003015 active site 293614003016 N-terminal domain interface [polypeptide binding]; other site 293614003017 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 293614003018 substrate binding site [chemical binding]; other site 293614003019 active site