-- dump date   	20140620_033546
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
391896000001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
391896000002	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
391896000003	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
391896000004	catalytic residues [active]
391896000005	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
391896000006	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
391896000007	Walker A/P-loop; other site
391896000008	ATP binding site [chemical binding]; other site
391896000009	Q-loop/lid; other site
391896000010	ABC transporter signature motif; other site
391896000011	Walker B; other site
391896000012	D-loop; other site
391896000013	H-loop/switch region; other site
391896000014	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
391896000015	ABC-2 type transporter; Region: ABC2_membrane; cl17235
391896000016	putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567
391896000017	Rickettsial palindromic element RPE4 domain; Region: RPE4; TIGR03777
391896000018	Rickettsial palindromic element RPE4 domain; Region: RPE4; TIGR03777
391896000019	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192
391896000020	FAD binding pocket [chemical binding]; other site
391896000021	FAD binding motif [chemical binding]; other site
391896000022	phosphate binding motif [ion binding]; other site
391896000023	NAD binding pocket [chemical binding]; other site
391896000024	Iron coordination center [ion binding]; other site
391896000025	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
391896000026	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
391896000027	Catalytic site [active]
391896000028	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
391896000029	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
391896000030	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
391896000031	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
391896000032	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
391896000033	membrane protein insertase; Provisional; Region: PRK01318
391896000034	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
391896000035	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
391896000036	Mechanosensitive ion channel; Region: MS_channel; pfam00924
391896000037	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
391896000038	Uncharacterized conserved protein [Function unknown]; Region: COG1565
391896000039	Bacterial SH3 domain; Region: SH3_4; pfam06347
391896000040	Bacterial SH3 domain; Region: SH3_4; pfam06347
391896000041	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
391896000042	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
391896000043	TrkA-N domain; Region: TrkA_N; pfam02254
391896000044	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
391896000045	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
391896000046	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896000047	metabolite-proton symporter; Region: 2A0106; TIGR00883
391896000048	putative substrate translocation pore; other site
391896000049	EamA-like transporter family; Region: EamA; pfam00892
391896000050	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
391896000051	EamA-like transporter family; Region: EamA; pfam00892
391896000052	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
391896000053	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896000054	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896000055	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896000056	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
391896000057	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
391896000058	Protein of unknown function (DUF1013); Region: DUF1013; cl11533
391896000059	Putative transcriptional regulator [Transcription]; Region: COG1678
391896000060	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
391896000061	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
391896000062	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
391896000063	P loop; other site
391896000064	GTP binding site [chemical binding]; other site
391896000065	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
391896000066	binding surface
391896000067	TPR motif; other site
391896000068	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
391896000069	catalytic center binding site [active]
391896000070	ATP binding site [chemical binding]; other site
391896000071	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
391896000072	dihydropteroate synthase; Region: DHPS; TIGR01496
391896000073	substrate binding pocket [chemical binding]; other site
391896000074	dimer interface [polypeptide binding]; other site
391896000075	inhibitor binding site; inhibition site
391896000076	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
391896000077	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
391896000078	folate binding site [chemical binding]; other site
391896000079	NADP+ binding site [chemical binding]; other site
391896000080	recombination protein F; Reviewed; Region: recF; PRK00064
391896000081	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391896000082	Walker A/P-loop; other site
391896000083	ATP binding site [chemical binding]; other site
391896000084	Q-loop/lid; other site
391896000085	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391896000086	ABC transporter signature motif; other site
391896000087	Walker B; other site
391896000088	D-loop; other site
391896000089	H-loop/switch region; other site
391896000090	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
391896000091	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
391896000092	trmE is a tRNA modification GTPase; Region: trmE; cd04164
391896000093	G1 box; other site
391896000094	GTP/Mg2+ binding site [chemical binding]; other site
391896000095	Switch I region; other site
391896000096	G2 box; other site
391896000097	Switch II region; other site
391896000098	G3 box; other site
391896000099	G4 box; other site
391896000100	G5 box; other site
391896000101	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
391896000102	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896000103	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896000104	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896000105	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
391896000106	HicB family; Region: HicB; pfam05534
391896000107	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
391896000108	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
391896000109	dimer interface [polypeptide binding]; other site
391896000110	active site
391896000111	citrylCoA binding site [chemical binding]; other site
391896000112	NADH binding [chemical binding]; other site
391896000113	cationic pore residues; other site
391896000114	oxalacetate/citrate binding site [chemical binding]; other site
391896000115	coenzyme A binding site [chemical binding]; other site
391896000116	catalytic triad [active]
391896000117	GTPase CgtA; Reviewed; Region: obgE; PRK12299
391896000118	GTP1/OBG; Region: GTP1_OBG; pfam01018
391896000119	Obg GTPase; Region: Obg; cd01898
391896000120	G1 box; other site
391896000121	GTP/Mg2+ binding site [chemical binding]; other site
391896000122	Switch I region; other site
391896000123	G2 box; other site
391896000124	G3 box; other site
391896000125	Switch II region; other site
391896000126	G4 box; other site
391896000127	G5 box; other site
391896000128	Predicted permeases [General function prediction only]; Region: COG0795
391896000129	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
391896000130	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
391896000131	active site
391896000132	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
391896000133	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
391896000134	putative hydrolase; Provisional; Region: PRK02113
391896000135	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
391896000136	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391896000137	Walker A/P-loop; other site
391896000138	ATP binding site [chemical binding]; other site
391896000139	Q-loop/lid; other site
391896000140	ABC transporter signature motif; other site
391896000141	Walker B; other site
391896000142	D-loop; other site
391896000143	H-loop/switch region; other site
391896000144	Predicted aspartyl protease [General function prediction only]; Region: COG3577
391896000145	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
391896000146	catalytic motif [active]
391896000147	Catalytic residue [active]
391896000148	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
391896000149	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
391896000150	nudix motif; other site
391896000151	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
391896000152	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
391896000153	Transporter associated domain; Region: CorC_HlyC; smart01091
391896000154	metal-binding heat shock protein; Provisional; Region: PRK00016
391896000155	Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045
391896000156	lipoyl synthase; Provisional; Region: PRK05481
391896000157	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391896000158	FeS/SAM binding site; other site
391896000159	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
391896000160	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
391896000161	dimer interface [polypeptide binding]; other site
391896000162	active site
391896000163	glycine-pyridoxal phosphate binding site [chemical binding]; other site
391896000164	folate binding site [chemical binding]; other site
391896000165	putative hydrolase; Provisional; Region: PRK11460
391896000166	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
391896000167	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
391896000168	putative GSH binding site [chemical binding]; other site
391896000169	catalytic residues [active]
391896000170	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
391896000171	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
391896000172	minor groove reading motif; other site
391896000173	helix-hairpin-helix signature motif; other site
391896000174	substrate binding pocket [chemical binding]; other site
391896000175	active site
391896000176	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
391896000177	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
391896000178	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
391896000179	CAP-like domain; other site
391896000180	active site
391896000181	primary dimer interface [polypeptide binding]; other site
391896000182	Sporulation related domain; Region: SPOR; pfam05036
391896000183	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
391896000184	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
391896000185	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
391896000186	active site
391896000187	HIGH motif; other site
391896000188	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391896000189	KMSK motif region; other site
391896000190	tRNA binding surface [nucleotide binding]; other site
391896000191	DALR anticodon binding domain; Region: DALR_1; smart00836
391896000192	anticodon binding site; other site
391896000193	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
391896000194	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
391896000195	Zn2+ binding site [ion binding]; other site
391896000196	Mg2+ binding site [ion binding]; other site
391896000197	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
391896000198	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
391896000199	GIY-YIG motif/motif A; other site
391896000200	putative active site [active]
391896000201	putative metal binding site [ion binding]; other site
391896000202	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
391896000203	Gram-negative porin; Region: Porin_4; pfam13609
391896000204	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
391896000205	trimer interface [polypeptide binding]; other site
391896000206	active site
391896000207	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
391896000208	SecA binding site; other site
391896000209	Preprotein binding site; other site
391896000210	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391896000211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391896000212	active site
391896000213	phosphorylation site [posttranslational modification]
391896000214	intermolecular recognition site; other site
391896000215	dimerization interface [polypeptide binding]; other site
391896000216	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391896000217	DNA binding site [nucleotide binding]
391896000218	7-cyano-7-deazaguanine reductase; Region: QueF; TIGR03138
391896000219	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
391896000220	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
391896000221	F0F1 ATP synthase subunit B; Validated; Region: PRK06568
391896000222	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
391896000223	F0F1 ATP synthase subunit B'; Validated; Region: PRK06569
391896000224	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
391896000225	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
391896000226	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
391896000227	ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Region: ATP_synt_6_or_A; TIGR01131
391896000228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
391896000229	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
391896000230	Thioredoxin; Region: Thioredoxin_4; pfam13462
391896000231	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
391896000232	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
391896000233	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
391896000234	elongation factor Ts; Provisional; Region: tsf; PRK09377
391896000235	UBA/TS-N domain; Region: UBA; pfam00627
391896000236	Elongation factor TS; Region: EF_TS; pfam00889
391896000237	Elongation factor TS; Region: EF_TS; pfam00889
391896000238	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
391896000239	rRNA interaction site [nucleotide binding]; other site
391896000240	S8 interaction site; other site
391896000241	putative laminin-1 binding site; other site
391896000242	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
391896000243	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
391896000244	active site
391896000245	HIGH motif; other site
391896000246	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
391896000247	KMSKS motif; other site
391896000248	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
391896000249	tRNA binding surface [nucleotide binding]; other site
391896000250	anticodon binding site; other site
391896000251	Autotransporter beta-domain; Region: Autotransporter; pfam03797
391896000252	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
391896000253	50S ribosomal protein L31; Provisional; Region: PRK01397
391896000254	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
391896000255	G1 box; other site
391896000256	GTP/Mg2+ binding site [chemical binding]; other site
391896000257	Switch I region; other site
391896000258	G2 box; other site
391896000259	G3 box; other site
391896000260	Switch II region; other site
391896000261	G4 box; other site
391896000262	G5 box; other site
391896000263	Acetylglutamate kinase [Amino acid transport and metabolism]; Region: ArgB; COG0548
391896000264	nucleotide binding site [chemical binding]; other site
391896000265	substrate binding site [chemical binding]; other site
391896000266	type IV secretion system protein VirB3; Provisional; Region: PRK13899
391896000267	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896000268	putative transposase; Provisional; Region: PRK09857
391896000269	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
391896000270	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896000271	metabolite-proton symporter; Region: 2A0106; TIGR00883
391896000272	putative substrate translocation pore; other site
391896000273	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
391896000274	putative transposase; Provisional; Region: PRK09857
391896000275	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
391896000276	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
391896000277	active site
391896000278	NTP binding site [chemical binding]; other site
391896000279	metal binding triad [ion binding]; metal-binding site
391896000280	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
391896000281	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
391896000282	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
391896000283	dimerization interface 3.5A [polypeptide binding]; other site
391896000284	active site
391896000285	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
391896000286	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
391896000287	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
391896000288	DNA binding residues [nucleotide binding]
391896000289	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
391896000290	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
391896000291	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
391896000292	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
391896000293	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
391896000294	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
391896000295	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
391896000296	DNA primase, catalytic core; Region: dnaG; TIGR01391
391896000297	CHC2 zinc finger; Region: zf-CHC2; pfam01807
391896000298	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
391896000299	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
391896000300	active site
391896000301	metal binding site [ion binding]; metal-binding site
391896000302	interdomain interaction site; other site
391896000303	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
391896000304	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
391896000305	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
391896000306	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
391896000307	lipoate-protein ligase B; Provisional; Region: PRK14347
391896000308	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
391896000309	hypothetical protein; Validated; Region: PRK00153
391896000310	DNA polymerase III subunits gamma and tau; Validated; Region: PRK06645
391896000311	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391896000312	Walker A motif; other site
391896000313	ATP binding site [chemical binding]; other site
391896000314	Walker B motif; other site
391896000315	arginine finger; other site
391896000316	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
391896000317	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
391896000318	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
391896000319	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
391896000320	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
391896000321	ligand binding site [chemical binding]; other site
391896000322	homodimer interface [polypeptide binding]; other site
391896000323	NAD(P) binding site [chemical binding]; other site
391896000324	trimer interface B [polypeptide binding]; other site
391896000325	trimer interface A [polypeptide binding]; other site
391896000326	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
391896000327	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
391896000328	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896000329	metabolite-proton symporter; Region: 2A0106; TIGR00883
391896000330	putative substrate translocation pore; other site
391896000331	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
391896000332	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
391896000333	Helix-turn-helix domain; Region: HTH_25; pfam13413
391896000334	NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902
391896000335	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
391896000336	AAA ATPase domain; Region: AAA_16; pfam13191
391896000337	NACHT domain; Region: NACHT; pfam05729
391896000338	trigger factor; Provisional; Region: tig; PRK01490
391896000339	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
391896000340	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
391896000341	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
391896000342	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
391896000343	oligomeric interface; other site
391896000344	putative active site [active]
391896000345	homodimer interface [polypeptide binding]; other site
391896000346	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
391896000347	motif 1; other site
391896000348	dimer interface [polypeptide binding]; other site
391896000349	active site
391896000350	motif 2; other site
391896000351	motif 3; other site
391896000352	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
391896000353	DALR anticodon binding domain; Region: DALR_1; pfam05746
391896000354	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
391896000355	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
391896000356	Methyltransferase domain; Region: Methyltransf_31; pfam13847
391896000357	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896000358	S-adenosylmethionine binding site [chemical binding]; other site
391896000359	TLC ATP/ADP transporter; Region: TLC; pfam03219
391896000360	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
391896000361	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896000362	putative substrate translocation pore; other site
391896000363	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
391896000364	active site
391896000365	multimer interface [polypeptide binding]; other site
391896000366	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
391896000367	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
391896000368	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
391896000369	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
391896000370	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
391896000371	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
391896000372	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
391896000373	Magnesium ion binding site [ion binding]; other site
391896000374	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
391896000375	ParB-like nuclease domain; Region: ParBc; pfam02195
391896000376	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
391896000377	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391896000378	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391896000379	ABC transporter; Region: ABC_tran_2; pfam12848
391896000380	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391896000381	Protein of unknown function (DUF2672); Region: DUF2672; pfam10878
391896000382	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
391896000383	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
391896000384	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
391896000385	dimer interface [polypeptide binding]; other site
391896000386	putative tRNA-binding site [nucleotide binding]; other site
391896000387	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
391896000388	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391896000389	Walker A/P-loop; other site
391896000390	ATP binding site [chemical binding]; other site
391896000391	Q-loop/lid; other site
391896000392	ABC transporter signature motif; other site
391896000393	Walker B; other site
391896000394	D-loop; other site
391896000395	H-loop/switch region; other site
391896000396	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
391896000397	Permease; Region: Permease; pfam02405
391896000398	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
391896000399	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
391896000400	active site
391896000401	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
391896000402	dimer interface [polypeptide binding]; other site
391896000403	substrate binding site [chemical binding]; other site
391896000404	catalytic residues [active]
391896000405	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
391896000406	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
391896000407	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391896000408	active site
391896000409	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
391896000410	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
391896000411	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
391896000412	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
391896000413	putative acyl-acceptor binding pocket; other site
391896000414	aspartate aminotransferase; Provisional; Region: PRK05764
391896000415	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391896000416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391896000417	homodimer interface [polypeptide binding]; other site
391896000418	catalytic residue [active]
391896000419	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391896000420	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
391896000421	binding surface
391896000422	TPR motif; other site
391896000423	Methyltransferase domain; Region: Methyltransf_23; pfam13489
391896000424	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896000425	S-adenosylmethionine binding site [chemical binding]; other site
391896000426	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
391896000427	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
391896000428	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896000429	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896000430	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896000431	bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed; Region: PRK01544
391896000432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896000433	S-adenosylmethionine binding site [chemical binding]; other site
391896000434	Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220
391896000435	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
391896000436	putative active site [active]
391896000437	homotetrameric interface [polypeptide binding]; other site
391896000438	metal binding site [ion binding]; metal-binding site
391896000439	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
391896000440	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
391896000441	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391896000442	RNA binding surface [nucleotide binding]; other site
391896000443	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
391896000444	active site
391896000445	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
391896000446	Fe-S cluster binding site [ion binding]; other site
391896000447	active site
391896000448	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896000449	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896000450	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896000451	type IV secretion system ATPase VirB4; Provisional; Region: PRK13898
391896000452	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
391896000453	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
391896000454	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391896000455	Walker A/P-loop; other site
391896000456	ATP binding site [chemical binding]; other site
391896000457	Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704
391896000458	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
391896000459	Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704
391896000460	Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704
391896000461	Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704
391896000462	UGMP family protein; Validated; Region: PRK09604
391896000463	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
391896000464	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
391896000465	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
391896000466	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
391896000467	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
391896000468	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391896000469	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391896000470	non-specific DNA binding site [nucleotide binding]; other site
391896000471	salt bridge; other site
391896000472	sequence-specific DNA binding site [nucleotide binding]; other site
391896000473	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
391896000474	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
391896000475	putative active site [active]
391896000476	catalytic triad [active]
391896000477	putative dimer interface [polypeptide binding]; other site
391896000478	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06603
391896000479	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
391896000480	NAD binding site [chemical binding]; other site
391896000481	homotetramer interface [polypeptide binding]; other site
391896000482	homodimer interface [polypeptide binding]; other site
391896000483	substrate binding site [chemical binding]; other site
391896000484	active site
391896000485	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
391896000486	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
391896000487	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
391896000488	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
391896000489	ATP-NAD kinase; Region: NAD_kinase; pfam01513
391896000490	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353
391896000491	RecR protein; Region: RecR; pfam02132
391896000492	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
391896000493	putative active site [active]
391896000494	putative metal-binding site [ion binding]; other site
391896000495	tetramer interface [polypeptide binding]; other site
391896000496	Predicted membrane protein/domain [Function unknown]; Region: COG1714
391896000497	RDD family; Region: RDD; pfam06271
391896000498	Predicted membrane protein [Function unknown]; Region: COG1238
391896000499	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
391896000500	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
391896000501	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
391896000502	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
391896000503	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
391896000504	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
391896000505	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
391896000506	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
391896000507	putative active site [active]
391896000508	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
391896000509	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
391896000510	CoA-ligase; Region: Ligase_CoA; pfam00549
391896000511	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
391896000512	CoA binding domain; Region: CoA_binding; pfam02629
391896000513	CoA-ligase; Region: Ligase_CoA; pfam00549
391896000514	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896000515	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896000516	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896000517	phosphate acetyltransferase; Provisional; Region: PRK11890
391896000518	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
391896000519	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
391896000520	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
391896000521	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
391896000522	putative active site [active]
391896000523	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896000524	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
391896000525	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
391896000526	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
391896000527	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
391896000528	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896000529	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896000530	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
391896000531	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
391896000532	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
391896000533	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
391896000534	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
391896000535	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
391896000536	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896000537	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896000538	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896000539	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
391896000540	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
391896000541	G1 box; other site
391896000542	GTP/Mg2+ binding site [chemical binding]; other site
391896000543	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
391896000544	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
391896000545	Ferredoxin [Energy production and conversion]; Region: COG1146
391896000546	4Fe-4S binding domain; Region: Fer4; cl02805
391896000547	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
391896000548	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
391896000549	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896000550	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896000551	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896000552	DNA polymerase I; Provisional; Region: PRK05755
391896000553	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
391896000554	active site
391896000555	metal binding site 1 [ion binding]; metal-binding site
391896000556	putative 5' ssDNA interaction site; other site
391896000557	metal binding site 3; metal-binding site
391896000558	metal binding site 2 [ion binding]; metal-binding site
391896000559	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
391896000560	putative DNA binding site [nucleotide binding]; other site
391896000561	putative metal binding site [ion binding]; other site
391896000562	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
391896000563	active site
391896000564	DNA binding site [nucleotide binding]
391896000565	catalytic site [active]
391896000566	pyruvate phosphate dikinase; Provisional; Region: PRK09279
391896000567	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
391896000568	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
391896000569	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
391896000570	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
391896000571	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
391896000572	GSH binding site (G-site) [chemical binding]; other site
391896000573	C-terminal domain interface [polypeptide binding]; other site
391896000574	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
391896000575	N-terminal domain interface [polypeptide binding]; other site
391896000576	dimer interface [polypeptide binding]; other site
391896000577	substrate binding pocket (H-site) [chemical binding]; other site
391896000578	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
391896000579	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
391896000580	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
391896000581	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
391896000582	FMN binding site [chemical binding]; other site
391896000583	active site
391896000584	catalytic residues [active]
391896000585	substrate binding site [chemical binding]; other site
391896000586	Putative catalytic NodB homology domain of uncharacterized protein RC0012 from Rickettsia conorii and its bacterial homologs; Region: CE4_RC0012_like; cd10963
391896000587	NodB motif; other site
391896000588	putative active site [active]
391896000589	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
391896000590	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
391896000591	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
391896000592	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
391896000593	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
391896000594	active site
391896000595	nucleophile elbow; other site
391896000596	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
391896000597	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
391896000598	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
391896000599	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
391896000600	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
391896000601	trimer interface [polypeptide binding]; other site
391896000602	active site
391896000603	UDP-GlcNAc binding site [chemical binding]; other site
391896000604	lipid binding site [chemical binding]; lipid-binding site
391896000605	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
391896000606	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
391896000607	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
391896000608	active site
391896000609	DNA Topoisomerase IV; Region: TOP4c; smart00434
391896000610	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480
391896000611	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
391896000612	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
391896000613	Protein export membrane protein; Region: SecD_SecF; pfam02355
391896000614	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
391896000615	SLBB domain; Region: SLBB; pfam10531
391896000616	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
391896000617	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
391896000618	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
391896000619	Catalytic site [active]
391896000620	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
391896000621	ribonuclease III; Reviewed; Region: rnc; PRK00102
391896000622	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
391896000623	dimerization interface [polypeptide binding]; other site
391896000624	active site
391896000625	metal binding site [ion binding]; metal-binding site
391896000626	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
391896000627	dsRNA binding site [nucleotide binding]; other site
391896000628	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391896000629	binding surface
391896000630	TPR repeat; Region: TPR_11; pfam13414
391896000631	TPR motif; other site
391896000632	TPR repeat; Region: TPR_11; pfam13414
391896000633	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391896000634	binding surface
391896000635	TPR motif; other site
391896000636	TPR repeat; Region: TPR_11; pfam13414
391896000637	GTPase Era; Reviewed; Region: era; PRK00089
391896000638	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
391896000639	G1 box; other site
391896000640	GTP/Mg2+ binding site [chemical binding]; other site
391896000641	Switch I region; other site
391896000642	G2 box; other site
391896000643	Switch II region; other site
391896000644	G3 box; other site
391896000645	G4 box; other site
391896000646	G5 box; other site
391896000647	KH domain; Region: KH_2; pfam07650
391896000648	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
391896000649	active site
391896000650	putative DNA-binding cleft [nucleotide binding]; other site
391896000651	dimer interface [polypeptide binding]; other site
391896000652	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
391896000653	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
391896000654	nucleotidyltransferase substrate binding protein, HI0074 family; Region: HI0074; TIGR01987
391896000655	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
391896000656	active site
391896000657	NTP binding site [chemical binding]; other site
391896000658	metal binding triad [ion binding]; metal-binding site
391896000659	antibiotic binding site [chemical binding]; other site
391896000660	Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045
391896000661	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
391896000662	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
391896000663	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
391896000664	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
391896000665	Walker A motif; other site
391896000666	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
391896000667	HflK protein; Region: hflK; TIGR01933
391896000668	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
391896000669	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
391896000670	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
391896000671	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
391896000672	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
391896000673	protein binding site [polypeptide binding]; other site
391896000674	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
391896000675	protein binding site [polypeptide binding]; other site
391896000676	hypothetical protein; Validated; Region: PRK01415
391896000677	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
391896000678	active site residue [active]
391896000679	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
391896000680	Iron-sulfur protein interface; other site
391896000681	proximal quinone binding site [chemical binding]; other site
391896000682	SdhD (CybS) interface [polypeptide binding]; other site
391896000683	proximal heme binding site [chemical binding]; other site
391896000684	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
391896000685	putative SdhC subunit interface [polypeptide binding]; other site
391896000686	putative proximal heme binding site [chemical binding]; other site
391896000687	putative Iron-sulfur protein interface [polypeptide binding]; other site
391896000688	putative proximal quinone binding site; other site
391896000689	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
391896000690	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
391896000691	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
391896000692	L-aspartate oxidase; Provisional; Region: PRK06175
391896000693	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
391896000694	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
391896000695	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391896000696	dimer interface [polypeptide binding]; other site
391896000697	conserved gate region; other site
391896000698	putative PBP binding loops; other site
391896000699	ABC-ATPase subunit interface; other site
391896000700	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
391896000701	S17 interaction site [polypeptide binding]; other site
391896000702	S8 interaction site; other site
391896000703	16S rRNA interaction site [nucleotide binding]; other site
391896000704	streptomycin interaction site [chemical binding]; other site
391896000705	23S rRNA interaction site [nucleotide binding]; other site
391896000706	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
391896000707	30S ribosomal protein S7; Validated; Region: PRK05302
391896000708	elongation factor G; Reviewed; Region: PRK00007
391896000709	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
391896000710	G1 box; other site
391896000711	putative GEF interaction site [polypeptide binding]; other site
391896000712	GTP/Mg2+ binding site [chemical binding]; other site
391896000713	Switch I region; other site
391896000714	G2 box; other site
391896000715	G3 box; other site
391896000716	Switch II region; other site
391896000717	G4 box; other site
391896000718	G5 box; other site
391896000719	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
391896000720	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
391896000721	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
391896000722	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
391896000723	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
391896000724	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
391896000725	putative homodimer interface [polypeptide binding]; other site
391896000726	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
391896000727	heterodimer interface [polypeptide binding]; other site
391896000728	homodimer interface [polypeptide binding]; other site
391896000729	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
391896000730	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
391896000731	23S rRNA interface [nucleotide binding]; other site
391896000732	L7/L12 interface [polypeptide binding]; other site
391896000733	putative thiostrepton binding site; other site
391896000734	L25 interface [polypeptide binding]; other site
391896000735	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
391896000736	mRNA/rRNA interface [nucleotide binding]; other site
391896000737	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
391896000738	23S rRNA interface [nucleotide binding]; other site
391896000739	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
391896000740	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
391896000741	core dimer interface [polypeptide binding]; other site
391896000742	peripheral dimer interface [polypeptide binding]; other site
391896000743	L10 interface [polypeptide binding]; other site
391896000744	L11 interface [polypeptide binding]; other site
391896000745	putative EF-Tu interaction site [polypeptide binding]; other site
391896000746	putative EF-G interaction site [polypeptide binding]; other site
391896000747	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
391896000748	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
391896000749	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
391896000750	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
391896000751	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
391896000752	RPB12 interaction site [polypeptide binding]; other site
391896000753	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
391896000754	RPB3 interaction site [polypeptide binding]; other site
391896000755	RPB1 interaction site [polypeptide binding]; other site
391896000756	RPB11 interaction site [polypeptide binding]; other site
391896000757	RPB10 interaction site [polypeptide binding]; other site
391896000758	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
391896000759	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
391896000760	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
391896000761	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
391896000762	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
391896000763	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
391896000764	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
391896000765	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
391896000766	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
391896000767	DNA binding site [nucleotide binding]
391896000768	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
391896000769	Uncharacterized conserved protein [Function unknown]; Region: COG2155
391896000770	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
391896000771	Protein export membrane protein; Region: SecD_SecF; cl14618
391896000772	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
391896000773	IHF dimer interface [polypeptide binding]; other site
391896000774	IHF - DNA interface [nucleotide binding]; other site
391896000775	DNA polymerase III subunit delta'; Validated; Region: PRK06581
391896000776	signal recognition particle protein; Provisional; Region: PRK10867
391896000777	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
391896000778	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
391896000779	P loop; other site
391896000780	GTP binding site [chemical binding]; other site
391896000781	Signal peptide binding domain; Region: SRP_SPB; pfam02978
391896000782	putative transposase; Provisional; Region: PRK09857
391896000783	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
391896000784	coproporphyrinogen III oxidase; Provisional; Region: PRK06582
391896000785	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391896000786	FeS/SAM binding site; other site
391896000787	HemN C-terminal domain; Region: HemN_C; pfam06969
391896000788	Domain of unknown function (DUF2383); Region: DUF2383; pfam09537
391896000789	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
391896000790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
391896000791	RNA methyltransferase, RsmE family; Region: TIGR00046
391896000792	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
391896000793	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
391896000794	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
391896000795	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
391896000796	dihydrodipicolinate reductase; Provisional; Region: PRK00048
391896000797	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
391896000798	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
391896000799	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
391896000800	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
391896000801	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391896000802	substrate binding pocket [chemical binding]; other site
391896000803	membrane-bound complex binding site; other site
391896000804	hinge residues; other site
391896000805	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
391896000806	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
391896000807	GatB domain; Region: GatB_Yqey; smart00845
391896000808	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
391896000809	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
391896000810	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
391896000811	ribosome recycling factor; Reviewed; Region: frr; PRK00083
391896000812	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
391896000813	hinge region; other site
391896000814	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
391896000815	putative nucleotide binding site [chemical binding]; other site
391896000816	uridine monophosphate binding site [chemical binding]; other site
391896000817	homohexameric interface [polypeptide binding]; other site
391896000818	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK06580
391896000819	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896000820	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896000821	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391896000822	non-specific DNA binding site [nucleotide binding]; other site
391896000823	salt bridge; other site
391896000824	sequence-specific DNA binding site [nucleotide binding]; other site
391896000825	Protein of unknown function (DUF2674); Region: DUF2674; pfam10879
391896000826	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
391896000827	putative coenzyme Q binding site [chemical binding]; other site
391896000828	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
391896000829	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
391896000830	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
391896000831	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
391896000832	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
391896000833	active site
391896000834	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
391896000835	protein binding site [polypeptide binding]; other site
391896000836	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
391896000837	putative substrate binding region [chemical binding]; other site
391896000838	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
391896000839	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
391896000840	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
391896000841	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
391896000842	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
391896000843	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
391896000844	Surface antigen; Region: Bac_surface_Ag; pfam01103
391896000845	Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572
391896000846	chaperone protein DnaJ; Provisional; Region: PRK14300
391896000847	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
391896000848	HSP70 interaction site [polypeptide binding]; other site
391896000849	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
391896000850	substrate binding site [polypeptide binding]; other site
391896000851	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
391896000852	Zn binding sites [ion binding]; other site
391896000853	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
391896000854	dimer interface [polypeptide binding]; other site
391896000855	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
391896000856	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
391896000857	nucleotide binding site [chemical binding]; other site
391896000858	NEF interaction site [polypeptide binding]; other site
391896000859	SBD interface [polypeptide binding]; other site
391896000860	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896000861	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896000862	Lipopolysaccharide-assembly; Region: LptE; cl01125
391896000863	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
391896000864	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
391896000865	diiron binding motif [ion binding]; other site
391896000866	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
391896000867	Subunit III/VIIa interface [polypeptide binding]; other site
391896000868	Phospholipid binding site [chemical binding]; other site
391896000869	Subunit I/III interface [polypeptide binding]; other site
391896000870	Subunit III/VIb interface [polypeptide binding]; other site
391896000871	Subunit III/VIa interface; other site
391896000872	Subunit III/Vb interface [polypeptide binding]; other site
391896000873	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
391896000874	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
391896000875	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
391896000876	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
391896000877	Walker A/P-loop; other site
391896000878	ATP binding site [chemical binding]; other site
391896000879	Q-loop/lid; other site
391896000880	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
391896000881	ABC transporter signature motif; other site
391896000882	Walker B; other site
391896000883	D-loop; other site
391896000884	H-loop/switch region; other site
391896000885	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
391896000886	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
391896000887	active site
391896000888	Zn binding site [ion binding]; other site
391896000889	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
391896000890	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
391896000891	TPP-binding site [chemical binding]; other site
391896000892	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
391896000893	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
391896000894	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
391896000895	E3 interaction surface; other site
391896000896	lipoyl attachment site [posttranslational modification]; other site
391896000897	e3 binding domain; Region: E3_binding; pfam02817
391896000898	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
391896000899	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
391896000900	active site
391896000901	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
391896000902	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
391896000903	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
391896000904	excinuclease ABC subunit B; Provisional; Region: PRK05298
391896000905	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391896000906	ATP binding site [chemical binding]; other site
391896000907	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391896000908	nucleotide binding region [chemical binding]; other site
391896000909	ATP-binding site [chemical binding]; other site
391896000910	Ultra-violet resistance protein B; Region: UvrB; pfam12344
391896000911	UvrB/uvrC motif; Region: UVR; pfam02151
391896000912	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
391896000913	GSH binding site [chemical binding]; other site
391896000914	catalytic residues [active]
391896000915	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
391896000916	Transglycosylase; Region: Transgly; pfam00912
391896000917	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
391896000918	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
391896000919	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
391896000920	catalytic residues [active]
391896000921	Methyltransferase domain; Region: Methyltransf_31; pfam13847
391896000922	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896000923	S-adenosylmethionine binding site [chemical binding]; other site
391896000924	PemK-like protein; Region: PemK; pfam02452
391896000925	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
391896000926	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
391896000927	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
391896000928	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
391896000929	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
391896000930	DNA-binding site [nucleotide binding]; DNA binding site
391896000931	RNA-binding motif; other site
391896000932	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
391896000933	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
391896000934	ATP binding site [chemical binding]; other site
391896000935	Mg++ binding site [ion binding]; other site
391896000936	motif III; other site
391896000937	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391896000938	nucleotide binding region [chemical binding]; other site
391896000939	ATP-binding site [chemical binding]; other site
391896000940	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896000941	putative substrate translocation pore; other site
391896000942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
391896000943	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
391896000944	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
391896000945	Serine protease inhibitor ecotin [General function prediction only]; Region: Eco; COG4574
391896000946	secondary substrate binding site; other site
391896000947	primary substrate binding site; other site
391896000948	inhibition loop; other site
391896000949	dimerization interface [polypeptide binding]; other site
391896000950	cell division protein FtsZ; Validated; Region: PRK09330
391896000951	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
391896000952	nucleotide binding site [chemical binding]; other site
391896000953	SulA interaction site; other site
391896000954	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896000955	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896000956	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896000957	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
391896000958	fumarate hydratase; Reviewed; Region: fumC; PRK00485
391896000959	Class II fumarases; Region: Fumarase_classII; cd01362
391896000960	active site
391896000961	tetramer interface [polypeptide binding]; other site
391896000962	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
391896000963	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
391896000964	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
391896000965	elongation factor Tu; Reviewed; Region: PRK00049
391896000966	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
391896000967	G1 box; other site
391896000968	GEF interaction site [polypeptide binding]; other site
391896000969	GTP/Mg2+ binding site [chemical binding]; other site
391896000970	Switch I region; other site
391896000971	G2 box; other site
391896000972	G3 box; other site
391896000973	Switch II region; other site
391896000974	G4 box; other site
391896000975	G5 box; other site
391896000976	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
391896000977	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
391896000978	Antibiotic Binding Site [chemical binding]; other site
391896000979	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
391896000980	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
391896000981	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
391896000982	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
391896000983	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
391896000984	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
391896000985	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
391896000986	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
391896000987	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
391896000988	putative translocon binding site; other site
391896000989	protein-rRNA interface [nucleotide binding]; other site
391896000990	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
391896000991	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
391896000992	G-X-X-G motif; other site
391896000993	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
391896000994	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
391896000995	23S rRNA interface [nucleotide binding]; other site
391896000996	5S rRNA interface [nucleotide binding]; other site
391896000997	putative antibiotic binding site [chemical binding]; other site
391896000998	L25 interface [polypeptide binding]; other site
391896000999	L27 interface [polypeptide binding]; other site
391896001000	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
391896001001	23S rRNA interface [nucleotide binding]; other site
391896001002	putative translocon interaction site; other site
391896001003	signal recognition particle (SRP54) interaction site; other site
391896001004	L23 interface [polypeptide binding]; other site
391896001005	trigger factor interaction site; other site
391896001006	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
391896001007	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
391896001008	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
391896001009	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
391896001010	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
391896001011	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
391896001012	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
391896001013	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
391896001014	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
391896001015	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
391896001016	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
391896001017	23S rRNA interface [nucleotide binding]; other site
391896001018	L21e interface [polypeptide binding]; other site
391896001019	5S rRNA interface [nucleotide binding]; other site
391896001020	L27 interface [polypeptide binding]; other site
391896001021	L5 interface [polypeptide binding]; other site
391896001022	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
391896001023	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
391896001024	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
391896001025	23S rRNA binding site [nucleotide binding]; other site
391896001026	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
391896001027	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
391896001028	SecY translocase; Region: SecY; pfam00344
391896001029	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
391896001030	30S ribosomal protein S13; Region: bact_S13; TIGR03631
391896001031	30S ribosomal protein S11; Validated; Region: PRK05309
391896001032	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
391896001033	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
391896001034	alphaNTD homodimer interface [polypeptide binding]; other site
391896001035	alphaNTD - beta interaction site [polypeptide binding]; other site
391896001036	alphaNTD - beta' interaction site [polypeptide binding]; other site
391896001037	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
391896001038	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
391896001039	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
391896001040	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391896001041	HD domain; Region: HD_4; pfam13328
391896001042	metabolite-proton symporter; Region: 2A0106; TIGR00883
391896001043	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896001044	putative substrate translocation pore; other site
391896001045	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
391896001046	Leucine rich repeat; Region: LRR_8; pfam13855
391896001047	Bacterial PH domain; Region: DUF304; pfam03703
391896001048	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
391896001049	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
391896001050	Cl binding site [ion binding]; other site
391896001051	oligomer interface [polypeptide binding]; other site
391896001052	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
391896001053	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001054	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001055	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
391896001056	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
391896001057	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
391896001058	oligomeric interface; other site
391896001059	putative active site [active]
391896001060	homodimer interface [polypeptide binding]; other site
391896001061	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
391896001062	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
391896001063	type IV secretion system component VirD4; Provisional; Region: PRK13897
391896001064	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
391896001065	Walker A motif; other site
391896001066	ATP binding site [chemical binding]; other site
391896001067	Walker B motif; other site
391896001068	type IV secretion system ATPase VirB11; Provisional; Region: PRK13900
391896001069	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
391896001070	Walker A motif; other site
391896001071	hexamer interface [polypeptide binding]; other site
391896001072	ATP binding site [chemical binding]; other site
391896001073	Walker B motif; other site
391896001074	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
391896001075	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
391896001076	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
391896001077	Protein of unknown function (DUF2706); Region: DUF2706; pfam10913
391896001078	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
391896001079	VirB7 interaction site; other site
391896001080	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
391896001081	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06591
391896001082	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
391896001083	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896001084	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896001085	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896001086	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06589
391896001087	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
391896001088	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: PRK01424
391896001089	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
391896001090	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001091	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001092	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001093	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001094	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
391896001095	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
391896001096	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
391896001097	DEAD/DEAH box helicase; Region: DEAD; pfam00270
391896001098	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
391896001099	SEC-C motif; Region: SEC-C; pfam02810
391896001100	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
391896001101	Leucine-rich repeats; other site
391896001102	Substrate binding site [chemical binding]; other site
391896001103	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
391896001104	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
391896001105	catalytic triad [active]
391896001106	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
391896001107	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
391896001108	RDD family; Region: RDD; pfam06271
391896001109	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
391896001110	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
391896001111	Subunit I/III interface [polypeptide binding]; other site
391896001112	D-pathway; other site
391896001113	Subunit I/VIIc interface [polypeptide binding]; other site
391896001114	Subunit I/IV interface [polypeptide binding]; other site
391896001115	Subunit I/II interface [polypeptide binding]; other site
391896001116	Low-spin heme (heme a) binding site [chemical binding]; other site
391896001117	Subunit I/VIIa interface [polypeptide binding]; other site
391896001118	Subunit I/VIa interface [polypeptide binding]; other site
391896001119	Dimer interface; other site
391896001120	Putative water exit pathway; other site
391896001121	Binuclear center (heme a3/CuB) [ion binding]; other site
391896001122	K-pathway; other site
391896001123	Subunit I/Vb interface [polypeptide binding]; other site
391896001124	Putative proton exit pathway; other site
391896001125	Subunit I/VIb interface; other site
391896001126	Subunit I/VIc interface [polypeptide binding]; other site
391896001127	Electron transfer pathway; other site
391896001128	Subunit I/VIIIb interface [polypeptide binding]; other site
391896001129	Subunit I/VIIb interface [polypeptide binding]; other site
391896001130	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
391896001131	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
391896001132	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
391896001133	Cytidylyltransferase [Cell envelope biogenesis, outer membrane / Lipid metabolism]; Region: TagD; COG0615
391896001134	active site
391896001135	nucleotide binding site [chemical binding]; other site
391896001136	HIGH motif; other site
391896001137	KMSKS motif; other site
391896001138	putative peptidase; Provisional; Region: PRK11649
391896001139	Peptidase family M23; Region: Peptidase_M23; pfam01551
391896001140	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
391896001141	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
391896001142	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
391896001143	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
391896001144	cofactor binding site; other site
391896001145	DNA binding site [nucleotide binding]
391896001146	substrate interaction site [chemical binding]; other site
391896001147	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01368
391896001148	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391896001149	cell division protein FtsW; Region: ftsW; TIGR02614
391896001150	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
391896001151	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
391896001152	active site
391896001153	homodimer interface [polypeptide binding]; other site
391896001154	Protein of unknown function (DUF328); Region: DUF328; pfam03883
391896001155	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984
391896001156	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
391896001157	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
391896001158	TM-ABC transporter signature motif; other site
391896001159	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
391896001160	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
391896001161	Walker A/P-loop; other site
391896001162	ATP binding site [chemical binding]; other site
391896001163	Q-loop/lid; other site
391896001164	ABC transporter signature motif; other site
391896001165	Walker B; other site
391896001166	D-loop; other site
391896001167	H-loop/switch region; other site
391896001168	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
391896001169	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
391896001170	catalytic core domain of  class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674
391896001171	active site
391896001172	HIGH motif; other site
391896001173	KMSKS motif; other site
391896001174	Predicted permeases [General function prediction only]; Region: COG0679
391896001175	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
391896001176	Malic enzyme, N-terminal domain; Region: malic; pfam00390
391896001177	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
391896001178	putative NAD(P) binding site [chemical binding]; other site
391896001179	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
391896001180	Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; Region: Sec7; cd00171
391896001181	active site/putative ARF binding site [active]
391896001182	ribonuclease P; Reviewed; Region: rnpA; PRK01492
391896001183	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
391896001184	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
391896001185	23S rRNA binding site [nucleotide binding]; other site
391896001186	L21 binding site [polypeptide binding]; other site
391896001187	L13 binding site [polypeptide binding]; other site
391896001188	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
391896001189	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
391896001190	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391896001191	FeS/SAM binding site; other site
391896001192	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
391896001193	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
391896001194	5S rRNA interface [nucleotide binding]; other site
391896001195	CTC domain interface [polypeptide binding]; other site
391896001196	L16 interface [polypeptide binding]; other site
391896001197	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
391896001198	putative active site [active]
391896001199	catalytic residue [active]
391896001200	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391896001201	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
391896001202	Coenzyme A binding pocket [chemical binding]; other site
391896001203	GTP-binding protein YchF; Reviewed; Region: PRK09601
391896001204	YchF GTPase; Region: YchF; cd01900
391896001205	G1 box; other site
391896001206	GTP/Mg2+ binding site [chemical binding]; other site
391896001207	Switch I region; other site
391896001208	G2 box; other site
391896001209	Switch II region; other site
391896001210	G3 box; other site
391896001211	G4 box; other site
391896001212	G5 box; other site
391896001213	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
391896001214	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
391896001215	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896001216	putative substrate translocation pore; other site
391896001217	GH3 auxin-responsive promoter; Region: GH3; pfam03321
391896001218	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
391896001219	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
391896001220	Mg++ binding site [ion binding]; other site
391896001221	putative catalytic motif [active]
391896001222	putative substrate binding site [chemical binding]; other site
391896001223	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
391896001224	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
391896001225	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391896001226	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391896001227	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
391896001228	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
391896001229	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391896001230	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391896001231	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
391896001232	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
391896001233	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391896001234	ATP binding site [chemical binding]; other site
391896001235	putative Mg++ binding site [ion binding]; other site
391896001236	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391896001237	nucleotide binding region [chemical binding]; other site
391896001238	ATP-binding site [chemical binding]; other site
391896001239	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
391896001240	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
391896001241	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
391896001242	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
391896001243	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
391896001244	DnaA N-terminal domain; Region: DnaA_N; pfam11638
391896001245	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391896001246	Walker A motif; other site
391896001247	ATP binding site [chemical binding]; other site
391896001248	Walker B motif; other site
391896001249	arginine finger; other site
391896001250	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
391896001251	DnaA box-binding interface [nucleotide binding]; other site
391896001252	Patatin [General function prediction only]; Region: COG3621
391896001253	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
391896001254	active site
391896001255	nucleophile elbow; other site
391896001256	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
391896001257	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
391896001258	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391896001259	RNA binding surface [nucleotide binding]; other site
391896001260	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
391896001261	UbiA prenyltransferase family; Region: UbiA; pfam01040
391896001262	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
391896001263	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
391896001264	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
391896001265	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
391896001266	putative dimer interface [polypeptide binding]; other site
391896001267	Protein of unknown function (DUF3154); Region: DUF3154; pfam11351
391896001268	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896001269	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896001270	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896001271	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391896001272	Mitochondria Fission Protein Fis1, cytosolic domain; Region: Fis1; cd12212
391896001273	Cephalosporin hydroxylase; Region: CmcI; pfam04989
391896001274	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
391896001275	active site
391896001276	iron coordination sites [ion binding]; other site
391896001277	substrate binding pocket [chemical binding]; other site
391896001278	Protein of unknown function (DUF2608); Region: DUF2608; pfam11019
391896001279	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
391896001280	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321
391896001281	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
391896001282	trimer interface [polypeptide binding]; other site
391896001283	active site
391896001284	substrate binding site [chemical binding]; other site
391896001285	CoA binding site [chemical binding]; other site
391896001286	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
391896001287	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391896001288	Coenzyme A binding pocket [chemical binding]; other site
391896001289	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
391896001290	homodimer interface [polypeptide binding]; other site
391896001291	active site
391896001292	putative chemical substrate binding site [chemical binding]; other site
391896001293	metal binding site [ion binding]; metal-binding site
391896001294	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001295	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
391896001296	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
391896001297	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678
391896001298	nudix motif; other site
391896001299	Protein of unknown function (DUF2000); Region: DUF2000; cl02074
391896001300	Protein of unknown function (DUF2000); Region: DUF2000; cl02074
391896001301	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
391896001302	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391896001303	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391896001304	Walker A/P-loop; other site
391896001305	ATP binding site [chemical binding]; other site
391896001306	Q-loop/lid; other site
391896001307	ABC transporter signature motif; other site
391896001308	Walker B; other site
391896001309	D-loop; other site
391896001310	H-loop/switch region; other site
391896001311	PIN domain; Region: PIN; pfam01850
391896001312	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
391896001313	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
391896001314	HicB family; Region: HicB; pfam05534
391896001315	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
391896001316	Ligand Binding Site [chemical binding]; other site
391896001317	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
391896001318	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
391896001319	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
391896001320	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
391896001321	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391896001322	Walker A motif; other site
391896001323	ATP binding site [chemical binding]; other site
391896001324	Walker B motif; other site
391896001325	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
391896001326	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
391896001327	RmuC family; Region: RmuC; pfam02646
391896001328	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
391896001329	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
391896001330	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
391896001331	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
391896001332	LicD family; Region: LicD; cl01378
391896001333	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
391896001334	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391896001335	active site
391896001336	HIGH motif; other site
391896001337	nucleotide binding site [chemical binding]; other site
391896001338	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
391896001339	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391896001340	active site
391896001341	KMSKS motif; other site
391896001342	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
391896001343	tRNA binding surface [nucleotide binding]; other site
391896001344	anticodon binding site; other site
391896001345	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
391896001346	Uncharacterized conserved protein [Function unknown]; Region: COG5464
391896001347	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
391896001348	RNA/DNA hybrid binding site [nucleotide binding]; other site
391896001349	active site
391896001350	co-chaperone HscB; Provisional; Region: hscB; PRK01356
391896001351	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
391896001352	HSP70 interaction site [polypeptide binding]; other site
391896001353	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
391896001354	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
391896001355	catalytic loop [active]
391896001356	iron binding site [ion binding]; other site
391896001357	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
391896001358	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
391896001359	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
391896001360	Ligand Binding Site [chemical binding]; other site
391896001361	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
391896001362	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
391896001363	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
391896001364	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
391896001365	Protein of unknown function (DUF2671); Region: DUF2671; pfam10877
391896001366	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391896001367	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391896001368	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391896001369	Walker A/P-loop; other site
391896001370	ATP binding site [chemical binding]; other site
391896001371	Q-loop/lid; other site
391896001372	ABC transporter signature motif; other site
391896001373	Walker B; other site
391896001374	D-loop; other site
391896001375	H-loop/switch region; other site
391896001376	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
391896001377	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
391896001378	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
391896001379	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391896001380	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
391896001381	putative metal binding site; other site
391896001382	toxin-antitoxin system, toxin component, Txe/YoeB family; Region: toxin_Txe_YoeB; TIGR02116
391896001383	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
391896001384	Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175
391896001385	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
391896001386	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
391896001387	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
391896001388	Ligand Binding Site [chemical binding]; other site
391896001389	amino acid transporter; Region: 2A0306; TIGR00909
391896001390	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
391896001391	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
391896001392	dimer interface [polypeptide binding]; other site
391896001393	motif 1; other site
391896001394	active site
391896001395	motif 2; other site
391896001396	motif 3; other site
391896001397	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
391896001398	anticodon binding site; other site
391896001399	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
391896001400	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
391896001401	ATP binding site [chemical binding]; other site
391896001402	active site
391896001403	substrate binding site [chemical binding]; other site
391896001404	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
391896001405	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
391896001406	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
391896001407	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
391896001408	active site
391896001409	dimer interface [polypeptide binding]; other site
391896001410	motif 1; other site
391896001411	motif 2; other site
391896001412	motif 3; other site
391896001413	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
391896001414	anticodon binding site; other site
391896001415	hypothetical protein; Validated; Region: PRK06620
391896001416	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
391896001417	proline/glycine betaine transporter; Provisional; Region: PRK10642
391896001418	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896001419	putative substrate translocation pore; other site
391896001420	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
391896001421	MraZ protein; Region: MraZ; pfam02381
391896001422	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
391896001423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896001424	S-adenosylmethionine binding site [chemical binding]; other site
391896001425	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
391896001426	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
391896001427	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
391896001428	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
391896001429	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
391896001430	120 KDa Rickettsia surface antigen; Region: 120_Rick_ant; pfam12574
391896001431	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391896001432	HD domain; Region: HD_4; pfam13328
391896001433	metabolite-proton symporter; Region: 2A0106; TIGR00883
391896001434	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391896001435	HD domain; Region: HD_4; pfam13328
391896001436	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391896001437	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391896001438	binding surface
391896001439	TPR motif; other site
391896001440	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391896001441	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391896001442	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001443	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001444	BRO family, N-terminal domain; Region: Bro-N; smart01040
391896001445	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391896001446	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391896001447	non-specific DNA binding site [nucleotide binding]; other site
391896001448	salt bridge; other site
391896001449	sequence-specific DNA binding site [nucleotide binding]; other site
391896001450	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
391896001451	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
391896001452	active site
391896001453	catalytic residues [active]
391896001454	metal binding site [ion binding]; metal-binding site
391896001455	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
391896001456	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
391896001457	substrate binding site [chemical binding]; other site
391896001458	putative active site [active]
391896001459	putative cosubstrate binding site; other site
391896001460	catalytic site [active]
391896001461	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
391896001462	substrate binding site [chemical binding]; other site
391896001463	Protein of unknown function (DUF563); Region: DUF563; cl15705
391896001464	Predicted ATPase [General function prediction only]; Region: COG1485
391896001465	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
391896001466	Walker A motif; other site
391896001467	ATP binding site [chemical binding]; other site
391896001468	Walker B motif; other site
391896001469	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391896001470	HD domain; Region: HD_4; pfam13328
391896001471	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896001472	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
391896001473	Substrate binding site; other site
391896001474	Mg++ binding site; other site
391896001475	hypothetical protein; Validated; Region: PRK00110
391896001476	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
391896001477	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
391896001478	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
391896001479	N-acetyl-D-glucosamine binding site [chemical binding]; other site
391896001480	Protein of unknown function (DUF2532); Region: DUF2532; pfam10811
391896001481	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
391896001482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896001483	S-adenosylmethionine binding site [chemical binding]; other site
391896001484	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
391896001485	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
391896001486	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391896001487	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
391896001488	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391896001489	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
391896001490	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
391896001491	N-acetyl-D-glucosamine binding site [chemical binding]; other site
391896001492	catalytic residue [active]
391896001493	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
391896001494	dimer interface [polypeptide binding]; other site
391896001495	catalytic triad [active]
391896001496	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
391896001497	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
391896001498	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001499	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001500	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001501	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001502	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
391896001503	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
391896001504	ring oligomerisation interface [polypeptide binding]; other site
391896001505	ATP/Mg binding site [chemical binding]; other site
391896001506	stacking interactions; other site
391896001507	hinge regions; other site
391896001508	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
391896001509	oligomerisation interface [polypeptide binding]; other site
391896001510	mobile loop; other site
391896001511	roof hairpin; other site
391896001512	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391896001513	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
391896001514	synthetase active site [active]
391896001515	NTP binding site [chemical binding]; other site
391896001516	metal binding site [ion binding]; metal-binding site
391896001517	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391896001518	HD domain; Region: HD_4; pfam13328
391896001519	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
391896001520	active site
391896001521	PCRF domain; Region: PCRF; pfam03462
391896001522	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
391896001523	RF-1 domain; Region: RF-1; pfam00472
391896001524	GTP-binding protein LepA; Provisional; Region: PRK05433
391896001525	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
391896001526	G1 box; other site
391896001527	putative GEF interaction site [polypeptide binding]; other site
391896001528	GTP/Mg2+ binding site [chemical binding]; other site
391896001529	Switch I region; other site
391896001530	G2 box; other site
391896001531	G3 box; other site
391896001532	Switch II region; other site
391896001533	G4 box; other site
391896001534	G5 box; other site
391896001535	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
391896001536	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
391896001537	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
391896001538	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001539	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001540	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001541	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001542	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
391896001543	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
391896001544	HIGH motif; other site
391896001545	Rickettsial palindromic element RPE4 domain; Region: RPE4; TIGR03777
391896001546	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
391896001547	active site
391896001548	KMSKS motif; other site
391896001549	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
391896001550	tRNA binding surface [nucleotide binding]; other site
391896001551	anticodon binding site; other site
391896001552	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
391896001553	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
391896001554	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
391896001555	putative active site [active]
391896001556	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
391896001557	Domain of unknown function DUF20; Region: UPF0118; pfam01594
391896001558	GrpE; Region: GrpE; pfam01025
391896001559	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
391896001560	dimer interface [polypeptide binding]; other site
391896001561	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
391896001562	ribonuclease PH; Reviewed; Region: rph; PRK00173
391896001563	Ribonuclease PH; Region: RNase_PH_bact; cd11362
391896001564	hexamer interface [polypeptide binding]; other site
391896001565	active site
391896001566	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
391896001567	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391896001568	RNA binding surface [nucleotide binding]; other site
391896001569	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896001570	S-adenosylmethionine binding site [chemical binding]; other site
391896001571	Transcriptional regulator; Region: Rrf2; cl17282
391896001572	Rrf2 family protein; Region: rrf2_super; TIGR00738
391896001573	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
391896001574	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
391896001575	heme-binding site [chemical binding]; other site
391896001576	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
391896001577	FAD binding pocket [chemical binding]; other site
391896001578	conserved FAD binding motif [chemical binding]; other site
391896001579	phosphate binding motif [ion binding]; other site
391896001580	beta-alpha-beta structure motif; other site
391896001581	NAD binding pocket [chemical binding]; other site
391896001582	ribosome maturation protein RimP; Reviewed; Region: PRK00092
391896001583	Sm and related proteins; Region: Sm_like; cl00259
391896001584	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
391896001585	putative oligomer interface [polypeptide binding]; other site
391896001586	putative RNA binding site [nucleotide binding]; other site
391896001587	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
391896001588	NusA N-terminal domain; Region: NusA_N; pfam08529
391896001589	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
391896001590	RNA binding site [nucleotide binding]; other site
391896001591	homodimer interface [polypeptide binding]; other site
391896001592	NusA-like KH domain; Region: KH_5; pfam13184
391896001593	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
391896001594	G-X-X-G motif; other site
391896001595	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
391896001596	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
391896001597	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
391896001598	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
391896001599	G1 box; other site
391896001600	putative GEF interaction site [polypeptide binding]; other site
391896001601	GTP/Mg2+ binding site [chemical binding]; other site
391896001602	Switch I region; other site
391896001603	G2 box; other site
391896001604	G3 box; other site
391896001605	Switch II region; other site
391896001606	G4 box; other site
391896001607	G5 box; other site
391896001608	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
391896001609	Translation-initiation factor 2; Region: IF-2; pfam11987
391896001610	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
391896001611	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
391896001612	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
391896001613	GIY-YIG motif/motif A; other site
391896001614	active site
391896001615	catalytic site [active]
391896001616	putative DNA binding site [nucleotide binding]; other site
391896001617	metal binding site [ion binding]; metal-binding site
391896001618	UvrB/uvrC motif; Region: UVR; pfam02151
391896001619	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
391896001620	Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; Region: GINS_A; cl17012
391896001621	Zeta toxin; Region: Zeta_toxin; pfam06414
391896001622	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
391896001623	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
391896001624	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
391896001625	Substrate binding site [chemical binding]; other site
391896001626	TPR repeat; Region: TPR_11; pfam13414
391896001627	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391896001628	binding surface
391896001629	TPR motif; other site
391896001630	TPR repeat; Region: TPR_11; pfam13414
391896001631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391896001632	TPR motif; other site
391896001633	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
391896001634	Fic/DOC family; Region: Fic; pfam02661
391896001635	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
391896001636	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
391896001637	HEAT repeats; Region: HEAT_2; pfam13646
391896001638	protein binding surface [polypeptide binding]; other site
391896001639	Transposase, Mutator family; Region: Transposase_mut; pfam00872
391896001640	MULE transposase domain; Region: MULE; pfam10551
391896001641	Transposase, Mutator family; Region: Transposase_mut; pfam00872
391896001642	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
391896001643	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
391896001644	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896001645	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896001646	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896001647	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
391896001648	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
391896001649	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
391896001650	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391896001651	active site
391896001652	DNA binding site [nucleotide binding]
391896001653	Int/Topo IB signature motif; other site
391896001654	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
391896001655	MgtE intracellular N domain; Region: MgtE_N; pfam03448
391896001656	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
391896001657	Divalent cation transporter; Region: MgtE; pfam01769
391896001658	similar to hypothetical protein
391896001659	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001660	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001661	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001662	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001663	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001664	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
391896001665	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001666	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
391896001667	conserved cys residue [active]
391896001668	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
391896001669	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
391896001670	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
391896001671	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391896001672	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
391896001673	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391896001674	Mg2+ binding site [ion binding]; other site
391896001675	G-X-G motif; other site
391896001676	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
391896001677	anchoring element; other site
391896001678	dimer interface [polypeptide binding]; other site
391896001679	ATP binding site [chemical binding]; other site
391896001680	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
391896001681	active site
391896001682	putative metal-binding site [ion binding]; other site
391896001683	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
391896001684	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
391896001685	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
391896001686	hinge; other site
391896001687	active site
391896001688	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
391896001689	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
391896001690	TLC ATP/ADP transporter; Region: TLC; pfam03219
391896001691	CTP synthetase; Validated; Region: pyrG; PRK05380
391896001692	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
391896001693	Catalytic site [active]
391896001694	active site
391896001695	UTP binding site [chemical binding]; other site
391896001696	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
391896001697	active site
391896001698	putative oxyanion hole; other site
391896001699	catalytic triad [active]
391896001700	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
391896001701	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
391896001702	Ligand binding site; other site
391896001703	oligomer interface; other site
391896001704	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
391896001705	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001706	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001707	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
391896001708	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14171
391896001709	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
391896001710	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
391896001711	homodimer interface [polypeptide binding]; other site
391896001712	NADP binding site [chemical binding]; other site
391896001713	substrate binding site [chemical binding]; other site
391896001714	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
391896001715	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
391896001716	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391896001717	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
391896001718	putative active site [active]
391896001719	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
391896001720	Spore Coat Protein U domain; Region: SCPU; pfam05229
391896001721	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
391896001722	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
391896001723	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
391896001724	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
391896001725	Spore Coat Protein U domain; Region: SCPU; pfam05229
391896001726	BRO family, N-terminal domain; Region: Bro-N; smart01040
391896001727	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
391896001728	putative active site [active]
391896001729	Ap4A binding site [chemical binding]; other site
391896001730	nudix motif; other site
391896001731	putative metal binding site [ion binding]; other site
391896001732	response regulator PleD; Reviewed; Region: pleD; PRK09581
391896001733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391896001734	active site
391896001735	phosphorylation site [posttranslational modification]
391896001736	intermolecular recognition site; other site
391896001737	dimerization interface [polypeptide binding]; other site
391896001738	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391896001739	active site
391896001740	phosphorylation site [posttranslational modification]
391896001741	intermolecular recognition site; other site
391896001742	dimerization interface [polypeptide binding]; other site
391896001743	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
391896001744	metal binding site [ion binding]; metal-binding site
391896001745	active site
391896001746	I-site; other site
391896001747	elongation factor P; Validated; Region: PRK00529
391896001748	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
391896001749	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
391896001750	RNA binding site [nucleotide binding]; other site
391896001751	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
391896001752	RNA binding site [nucleotide binding]; other site
391896001753	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
391896001754	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
391896001755	active site
391896001756	Domain of unknown function (DUF2610); Region: DUF2610; pfam11020
391896001757	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
391896001758	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
391896001759	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
391896001760	CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009
391896001761	HlyD family secretion protein; Region: HlyD; pfam00529
391896001762	HlyD family secretion protein; Region: HlyD_3; pfam13437
391896001763	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
391896001764	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
391896001765	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
391896001766	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
391896001767	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391896001768	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391896001769	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
391896001770	FAD binding domain; Region: FAD_binding_4; pfam01565
391896001771	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
391896001772	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
391896001773	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
391896001774	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391896001775	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
391896001776	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
391896001777	Cell division protein FtsQ; Region: FtsQ; pfam03799
391896001778	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896001779	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896001780	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896001781	cell division protein FtsA; Region: ftsA; TIGR01174
391896001782	Cell division protein FtsA; Region: FtsA; smart00842
391896001783	Cell division protein FtsA; Region: FtsA; pfam14450
391896001784	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
391896001785	Cytochrome c2 [Energy production and conversion]; Region: COG3474
391896001786	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
391896001787	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
391896001788	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391896001789	AAA domain; Region: AAA_14; pfam13173
391896001790	hypothetical protein; Provisional; Region: PRK06661
391896001791	intersubunit interface [polypeptide binding]; other site
391896001792	active site
391896001793	Zn2+ binding site [ion binding]; other site
391896001794	Transcriptional regulator; Region: Rrf2; cl17282
391896001795	Rrf2 family protein; Region: rrf2_super; TIGR00738
391896001796	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
391896001797	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
391896001798	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391896001799	catalytic residue [active]
391896001800	cysteine desulfurase; Provisional; Region: PRK14012
391896001801	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
391896001802	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391896001803	catalytic residue [active]
391896001804	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
391896001805	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
391896001806	trimerization site [polypeptide binding]; other site
391896001807	active site
391896001808	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
391896001809	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896001810	putative substrate translocation pore; other site
391896001811	Fic family protein [Function unknown]; Region: COG3177
391896001812	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
391896001813	Fic/DOC family; Region: Fic; pfam02661
391896001814	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
391896001815	RuvA N terminal domain; Region: RuvA_N; pfam01330
391896001816	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
391896001817	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
391896001818	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391896001819	Walker A motif; other site
391896001820	ATP binding site [chemical binding]; other site
391896001821	Walker B motif; other site
391896001822	arginine finger; other site
391896001823	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
391896001824	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391896001825	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391896001826	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
391896001827	Walker A/P-loop; other site
391896001828	ATP binding site [chemical binding]; other site
391896001829	Q-loop/lid; other site
391896001830	ABC transporter signature motif; other site
391896001831	Walker B; other site
391896001832	D-loop; other site
391896001833	H-loop/switch region; other site
391896001834	muropeptide transporter; Reviewed; Region: ampG; PRK11902
391896001835	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896001836	putative substrate translocation pore; other site
391896001837	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
391896001838	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
391896001839	replicative DNA helicase; Provisional; Region: PRK09165
391896001840	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
391896001841	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
391896001842	Walker A motif; other site
391896001843	ATP binding site [chemical binding]; other site
391896001844	Walker B motif; other site
391896001845	DNA binding loops [nucleotide binding]
391896001846	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
391896001847	putative active site [active]
391896001848	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
391896001849	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
391896001850	Flavoprotein; Region: Flavoprotein; pfam02441
391896001851	primosome assembly protein PriA; Validated; Region: PRK05580
391896001852	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391896001853	ATP binding site [chemical binding]; other site
391896001854	putative Mg++ binding site [ion binding]; other site
391896001855	helicase superfamily c-terminal domain; Region: HELICc; smart00490
391896001856	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001857	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001858	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001859	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001860	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
391896001861	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001862	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001863	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896001864	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
391896001865	dimer interface [polypeptide binding]; other site
391896001866	allosteric magnesium binding site [ion binding]; other site
391896001867	active site
391896001868	aspartate-rich active site metal binding site; other site
391896001869	Schiff base residues; other site
391896001870	Autotransporter beta-domain; Region: Autotransporter; smart00869
391896001871	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896001872	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896001873	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896001874	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
391896001875	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
391896001876	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
391896001877	active site
391896001878	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
391896001879	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391896001880	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391896001881	non-specific DNA binding site [nucleotide binding]; other site
391896001882	salt bridge; other site
391896001883	sequence-specific DNA binding site [nucleotide binding]; other site
391896001884	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
391896001885	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
391896001886	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
391896001887	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
391896001888	Protein of unknown function (DUF497); Region: DUF497; pfam04365
391896001889	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
391896001890	active site
391896001891	catalytic residues [active]
391896001892	metal binding site [ion binding]; metal-binding site
391896001893	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
391896001894	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
391896001895	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896001896	TPR repeat; Region: TPR_11; pfam13414
391896001897	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391896001898	binding surface
391896001899	TPR motif; other site
391896001900	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391896001901	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
391896001902	conserved cys residue [active]
391896001903	Orientia OTT_1508-like deaminase; Region: OTT_1508_deam; pfam14441
391896001904	AAA domain; Region: AAA_14; pfam13173
391896001905	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391896001906	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
391896001907	DNA polymerase III subunit beta; Validated; Region: PRK05643
391896001908	putative DNA binding surface [nucleotide binding]; other site
391896001909	dimer interface [polypeptide binding]; other site
391896001910	beta-clamp/clamp loader binding surface; other site
391896001911	beta-clamp/translesion DNA polymerase binding surface; other site
391896001912	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
391896001913	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
391896001914	putative tRNA-binding site [nucleotide binding]; other site
391896001915	B3/4 domain; Region: B3_4; pfam03483
391896001916	Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045
391896001917	tRNA synthetase B5 domain; Region: B5; smart00874
391896001918	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
391896001919	dimer interface [polypeptide binding]; other site
391896001920	motif 1; other site
391896001921	motif 3; other site
391896001922	motif 2; other site
391896001923	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
391896001924	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
391896001925	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
391896001926	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
391896001927	dimer interface [polypeptide binding]; other site
391896001928	motif 1; other site
391896001929	active site
391896001930	motif 2; other site
391896001931	motif 3; other site
391896001932	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
391896001933	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
391896001934	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391896001935	FeS/SAM binding site; other site
391896001936	diaminopimelate epimerase; Region: DapF; TIGR00652
391896001937	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
391896001938	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
391896001939	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
391896001940	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391896001941	Outer membrane efflux protein; Region: OEP; pfam02321
391896001942	Outer membrane efflux protein; Region: OEP; pfam02321
391896001943	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
391896001944	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
391896001945	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
391896001946	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391896001947	non-specific DNA binding site [nucleotide binding]; other site
391896001948	salt bridge; other site
391896001949	sequence-specific DNA binding site [nucleotide binding]; other site
391896001950	malate dehydrogenase; Reviewed; Region: PRK06223
391896001951	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
391896001952	NAD(P) binding site [chemical binding]; other site
391896001953	dimer interface [polypeptide binding]; other site
391896001954	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391896001955	substrate binding site [chemical binding]; other site
391896001956	TMPIT-like protein; Region: TMPIT; pfam07851
391896001957	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
391896001958	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
391896001959	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
391896001960	active site
391896001961	Protein of unknown function (DUF2608); Region: DUF2608; pfam11019
391896001962	Protein of unknown function (DUF2608); Region: DUF2608; pfam11019
391896001963	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
391896001964	AAA domain; Region: AAA_22; pfam13401
391896001965	AAA domain; Region: AAA_14; pfam13173
391896001966	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391896001967	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391896001968	binding surface
391896001969	TPR motif; other site
391896001970	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391896001971	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391896001972	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391896001973	binding surface
391896001974	TPR motif; other site
391896001975	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391896001976	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391896001977	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391896001978	binding surface
391896001979	TPR motif; other site
391896001980	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391896001981	hypothetical protein; Reviewed; Region: PRK01530
391896001982	heat shock protein 90; Provisional; Region: PRK05218
391896001983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391896001984	ATP binding site [chemical binding]; other site
391896001985	Mg2+ binding site [ion binding]; other site
391896001986	G-X-G motif; other site
391896001987	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
391896001988	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
391896001989	substrate-cofactor binding pocket; other site
391896001990	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391896001991	catalytic residue [active]
391896001992	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391896001993	active site
391896001994	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
391896001995	Apolipoprotein L; Region: ApoL; pfam05461
391896001996	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK06617
391896001997	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
391896001998	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612
391896001999	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896002000	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
391896002001	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
391896002002	30S subunit binding site; other site
391896002003	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
391896002004	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
391896002005	trimer interface [polypeptide binding]; other site
391896002006	putative metal binding site [ion binding]; other site
391896002007	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
391896002008	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
391896002009	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
391896002010	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
391896002011	active site
391896002012	catalytic residues [active]
391896002013	metal binding site [ion binding]; metal-binding site
391896002014	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
391896002015	Part of AAA domain; Region: AAA_19; pfam13245
391896002016	Family description; Region: UvrD_C_2; pfam13538
391896002017	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896002018	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896002019	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896002020	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391896002021	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
391896002022	active site
391896002023	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
391896002024	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
391896002025	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
391896002026	Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751
391896002027	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
391896002028	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
391896002029	catalytic site [active]
391896002030	putative active site [active]
391896002031	putative substrate binding site [chemical binding]; other site
391896002032	HRDC domain; Region: HRDC; cl02578
391896002033	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
391896002034	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
391896002035	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
391896002036	DNA binding site [nucleotide binding]
391896002037	active site
391896002038	TraX protein; Region: TraX; cl05434
391896002039	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
391896002040	MviN-like protein; Region: MVIN; pfam03023
391896002041	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
391896002042	dimer interface [polypeptide binding]; other site
391896002043	substrate binding site [chemical binding]; other site
391896002044	metal binding sites [ion binding]; metal-binding site
391896002045	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
391896002046	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
391896002047	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
391896002048	Cu(I) binding site [ion binding]; other site
391896002049	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
391896002050	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
391896002051	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
391896002052	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391896002053	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
391896002054	putative ADP-binding pocket [chemical binding]; other site
391896002055	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
391896002056	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
391896002057	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
391896002058	catalytic site [active]
391896002059	Protein of unknown function (DUF2608); Region: DUF2608; pfam11019
391896002060	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
391896002061	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
391896002062	HlyD family secretion protein; Region: HlyD_3; pfam13437
391896002063	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391896002064	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
391896002065	active site
391896002066	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
391896002067	active site
391896002068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
391896002069	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
391896002070	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
391896002071	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
391896002072	active site
391896002073	homodimer interface [polypeptide binding]; other site
391896002074	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
391896002075	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
391896002076	NAD(P) binding site [chemical binding]; other site
391896002077	homodimer interface [polypeptide binding]; other site
391896002078	substrate binding site [chemical binding]; other site
391896002079	active site
391896002080	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
391896002081	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
391896002082	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
391896002083	NADP binding site [chemical binding]; other site
391896002084	active site
391896002085	putative substrate binding site [chemical binding]; other site
391896002086	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
391896002087	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391896002088	active site
391896002089	HIGH motif; other site
391896002090	nucleotide binding site [chemical binding]; other site
391896002091	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
391896002092	active site
391896002093	KMSKS motif; other site
391896002094	DNA topoisomerase I; Validated; Region: PRK06599
391896002095	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
391896002096	active site
391896002097	interdomain interaction site; other site
391896002098	putative metal-binding site [ion binding]; other site
391896002099	nucleotide binding site [chemical binding]; other site
391896002100	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
391896002101	domain I; other site
391896002102	DNA binding groove [nucleotide binding]
391896002103	phosphate binding site [ion binding]; other site
391896002104	domain II; other site
391896002105	domain III; other site
391896002106	nucleotide binding site [chemical binding]; other site
391896002107	catalytic site [active]
391896002108	domain IV; other site
391896002109	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
391896002110	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
391896002111	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
391896002112	DNA protecting protein DprA; Region: dprA; TIGR00732
391896002113	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
391896002114	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
391896002115	dimer interface [polypeptide binding]; other site
391896002116	decamer (pentamer of dimers) interface [polypeptide binding]; other site
391896002117	catalytic triad [active]
391896002118	peroxidatic and resolving cysteines [active]
391896002119	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
391896002120	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
391896002121	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
391896002122	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
391896002123	substrate binding pocket [chemical binding]; other site
391896002124	chain length determination region; other site
391896002125	substrate-Mg2+ binding site; other site
391896002126	catalytic residues [active]
391896002127	aspartate-rich region 1; other site
391896002128	active site lid residues [active]
391896002129	aspartate-rich region 2; other site
391896002130	Helix-turn-helix domain; Region: HTH_37; pfam13744
391896002131	non-specific DNA binding site [nucleotide binding]; other site
391896002132	salt bridge; other site
391896002133	sequence-specific DNA binding site [nucleotide binding]; other site
391896002134	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
391896002135	TLC ATP/ADP transporter; Region: TLC; pfam03219
391896002136	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
391896002137	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
391896002138	Ligand binding site; other site
391896002139	metal-binding site
391896002140	AmpG-like permease; Region: 2A0125; TIGR00901
391896002141	LysE type translocator; Region: LysE; cl00565
391896002142	Lysine efflux permease [General function prediction only]; Region: COG1279
391896002143	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
391896002144	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
391896002145	active site
391896002146	HemY protein N-terminus; Region: HemY_N; pfam07219
391896002147	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
391896002148	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
391896002149	homotetramer interface [polypeptide binding]; other site
391896002150	FMN binding site [chemical binding]; other site
391896002151	homodimer contacts [polypeptide binding]; other site
391896002152	putative active site [active]
391896002153	putative substrate binding site [chemical binding]; other site
391896002154	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
391896002155	dimer interface [polypeptide binding]; other site
391896002156	putative radical transfer pathway; other site
391896002157	diiron center [ion binding]; other site
391896002158	tyrosyl radical; other site
391896002159	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
391896002160	Class I ribonucleotide reductase; Region: RNR_I; cd01679
391896002161	active site
391896002162	dimer interface [polypeptide binding]; other site
391896002163	catalytic residues [active]
391896002164	effector binding site; other site
391896002165	R2 peptide binding site; other site
391896002166	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
391896002167	IHF - DNA interface [nucleotide binding]; other site
391896002168	IHF dimer interface [polypeptide binding]; other site
391896002169	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
391896002170	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
391896002171	tandem repeat interface [polypeptide binding]; other site
391896002172	oligomer interface [polypeptide binding]; other site
391896002173	active site residues [active]
391896002174	transcription termination factor Rho; Provisional; Region: rho; PRK09376
391896002175	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
391896002176	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
391896002177	RNA binding site [nucleotide binding]; other site
391896002178	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
391896002179	multimer interface [polypeptide binding]; other site
391896002180	Walker A motif; other site
391896002181	ATP binding site [chemical binding]; other site
391896002182	Walker B motif; other site
391896002183	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
391896002184	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
391896002185	catalytic residues [active]
391896002186	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
391896002187	SmpB-tmRNA interface; other site
391896002188	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
391896002189	dihydrodipicolinate synthase; Region: dapA; TIGR00674
391896002190	dimer interface [polypeptide binding]; other site
391896002191	active site
391896002192	catalytic residue [active]
391896002193	branched-chain amino acid aminotransferase; Validated; Region: PRK06606
391896002194	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
391896002195	homodimer interface [polypeptide binding]; other site
391896002196	substrate-cofactor binding pocket; other site
391896002197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391896002198	catalytic residue [active]
391896002199	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391896002200	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391896002201	active site
391896002202	phosphorylation site [posttranslational modification]
391896002203	intermolecular recognition site; other site
391896002204	dimerization interface [polypeptide binding]; other site
391896002205	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391896002206	DNA binding site [nucleotide binding]
391896002207	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391896002208	dimer interface [polypeptide binding]; other site
391896002209	phosphorylation site [posttranslational modification]
391896002210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391896002211	ATP binding site [chemical binding]; other site
391896002212	Mg2+ binding site [ion binding]; other site
391896002213	G-X-G motif; other site
391896002214	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
391896002215	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
391896002216	catalytic residue [active]
391896002217	putative FPP diphosphate  binding site; other site
391896002218	putative FPP binding hydrophobic cleft; other site
391896002219	dimer interface [polypeptide binding]; other site
391896002220	putative IPP diphosphate binding site; other site
391896002221	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
391896002222	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
391896002223	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
391896002224	Septum formation initiator; Region: DivIC; pfam04977
391896002225	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
391896002226	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
391896002227	catalytic site [active]
391896002228	putative active site [active]
391896002229	putative substrate binding site [chemical binding]; other site
391896002230	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
391896002231	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
391896002232	Na binding site [ion binding]; other site
391896002233	Fic family protein [Function unknown]; Region: COG3177
391896002234	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
391896002235	Fic/DOC family; Region: Fic; pfam02661
391896002236	Fic family protein [Function unknown]; Region: COG3177
391896002237	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
391896002238	Fic/DOC family; Region: Fic; pfam02661
391896002239	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
391896002240	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
391896002241	DXD motif; other site
391896002242	PemK-like protein; Region: PemK; pfam02452
391896002243	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
391896002244	Phage portal protein; Region: Phage_portal; pfam04860
391896002245	Phage-related protein [Function unknown]; Region: COG4695
391896002246	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
391896002247	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391896002248	dimer interface [polypeptide binding]; other site
391896002249	conserved gate region; other site
391896002250	putative PBP binding loops; other site
391896002251	ABC-ATPase subunit interface; other site
391896002252	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
391896002253	exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280
391896002254	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
391896002255	RimM N-terminal domain; Region: RimM; pfam01782
391896002256	PRC-barrel domain; Region: PRC; pfam05239
391896002257	120 KDa Rickettsia surface antigen; Region: 120_Rick_ant; pfam12574
391896002258	120 KDa Rickettsia surface antigen; Region: 120_Rick_ant; pfam12574
391896002259	TLC ATP/ADP transporter; Region: TLC; pfam03219
391896002260	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01528
391896002261	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
391896002262	RNA binding site [nucleotide binding]; other site
391896002263	active site
391896002264	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
391896002265	16S/18S rRNA binding site [nucleotide binding]; other site
391896002266	S13e-L30e interaction site [polypeptide binding]; other site
391896002267	25S rRNA binding site [nucleotide binding]; other site
391896002268	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
391896002269	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
391896002270	RNase E interface [polypeptide binding]; other site
391896002271	trimer interface [polypeptide binding]; other site
391896002272	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
391896002273	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
391896002274	RNase E interface [polypeptide binding]; other site
391896002275	trimer interface [polypeptide binding]; other site
391896002276	active site
391896002277	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
391896002278	putative nucleic acid binding region [nucleotide binding]; other site
391896002279	G-X-X-G motif; other site
391896002280	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
391896002281	RNA binding site [nucleotide binding]; other site
391896002282	domain interface; other site
391896002283	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
391896002284	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
391896002285	putative active site [active]
391896002286	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
391896002287	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
391896002288	OstA-like protein; Region: OstA; cl00844
391896002289	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
391896002290	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
391896002291	Walker A/P-loop; other site
391896002292	ATP binding site [chemical binding]; other site
391896002293	Q-loop/lid; other site
391896002294	ABC transporter signature motif; other site
391896002295	Walker B; other site
391896002296	D-loop; other site
391896002297	H-loop/switch region; other site
391896002298	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
391896002299	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
391896002300	active site
391896002301	substrate binding site [chemical binding]; other site
391896002302	metal binding site [ion binding]; metal-binding site
391896002303	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
391896002304	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
391896002305	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
391896002306	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
391896002307	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
391896002308	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
391896002309	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
391896002310	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
391896002311	Protein required for attachment to host cells; Region: Host_attach; cl02398
391896002312	Protein required for attachment to host cells; Region: Host_attach; cl02398
391896002313	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
391896002314	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
391896002315	putative acyl-acceptor binding pocket; other site
391896002316	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
391896002317	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
391896002318	active site
391896002319	HIGH motif; other site
391896002320	dimer interface [polypeptide binding]; other site
391896002321	KMSKS motif; other site
391896002322	DNA gyrase subunit A; Validated; Region: PRK05560
391896002323	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
391896002324	CAP-like domain; other site
391896002325	active site
391896002326	primary dimer interface [polypeptide binding]; other site
391896002327	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391896002328	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391896002329	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391896002330	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391896002331	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391896002332	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
391896002333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391896002334	Walker A motif; other site
391896002335	ATP binding site [chemical binding]; other site
391896002336	Walker B motif; other site
391896002337	arginine finger; other site
391896002338	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
391896002339	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
391896002340	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
391896002341	tetramer interface [polypeptide binding]; other site
391896002342	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391896002343	catalytic residue [active]
391896002344	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
391896002345	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391896002346	Rickettsial palindromic element RPE4 domain; Region: RPE4; TIGR03777
391896002347	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
391896002348	GTP cyclohydrolase I; Provisional; Region: PLN03044
391896002349	active site
391896002350	prolyl-tRNA synthetase; Provisional; Region: PRK12325
391896002351	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
391896002352	dimer interface [polypeptide binding]; other site
391896002353	motif 1; other site
391896002354	active site
391896002355	motif 2; other site
391896002356	motif 3; other site
391896002357	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
391896002358	anticodon binding site; other site
391896002359	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896002360	metabolite-proton symporter; Region: 2A0106; TIGR00883
391896002361	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391896002362	HD domain; Region: HD_4; pfam13328
391896002363	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
391896002364	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
391896002365	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
391896002366	Sulfatase; Region: Sulfatase; pfam00884
391896002367	frataxin-like protein; Provisional; Region: cyaY; PRK01379
391896002368	putative iron binding site [ion binding]; other site
391896002369	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
391896002370	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
391896002371	dimerization interface [polypeptide binding]; other site
391896002372	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
391896002373	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
391896002374	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
391896002375	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
391896002376	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
391896002377	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
391896002378	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
391896002379	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391896002380	Walker A motif; other site
391896002381	ATP binding site [chemical binding]; other site
391896002382	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
391896002383	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
391896002384	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
391896002385	active site
391896002386	HslU subunit interaction site [polypeptide binding]; other site
391896002387	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
391896002388	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
391896002389	nucleotide binding site/active site [active]
391896002390	HIT family signature motif; other site
391896002391	catalytic residue [active]
391896002392	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
391896002393	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
391896002394	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
391896002395	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
391896002396	Walker A/P-loop; other site
391896002397	ATP binding site [chemical binding]; other site
391896002398	Q-loop/lid; other site
391896002399	ABC transporter signature motif; other site
391896002400	Walker B; other site
391896002401	D-loop; other site
391896002402	H-loop/switch region; other site
391896002403	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
391896002404	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
391896002405	HlyD family secretion protein; Region: HlyD_3; pfam13437
391896002406	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
391896002407	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
391896002408	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
391896002409	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12507
391896002410	Predicted subunit of the Multisubunit Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: COG1563
391896002411	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
391896002412	Protein of unknown function (DUF2670); Region: DUF2670; pfam10875
391896002413	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
391896002414	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
391896002415	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
391896002416	[2Fe-2S] cluster binding site [ion binding]; other site
391896002417	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
391896002418	Qi binding site; other site
391896002419	cytochrome b; Provisional; Region: CYTB; MTH00191
391896002420	intrachain domain interface; other site
391896002421	interchain domain interface [polypeptide binding]; other site
391896002422	heme bH binding site [chemical binding]; other site
391896002423	heme bL binding site [chemical binding]; other site
391896002424	Qo binding site; other site
391896002425	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
391896002426	interchain domain interface [polypeptide binding]; other site
391896002427	intrachain domain interface; other site
391896002428	Qi binding site; other site
391896002429	Qo binding site; other site
391896002430	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
391896002431	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896002432	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896002433	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896002434	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
391896002435	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
391896002436	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
391896002437	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
391896002438	dimerization interface [polypeptide binding]; other site
391896002439	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391896002440	dimer interface [polypeptide binding]; other site
391896002441	phosphorylation site [posttranslational modification]
391896002442	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391896002443	ATP binding site [chemical binding]; other site
391896002444	Mg2+ binding site [ion binding]; other site
391896002445	G-X-G motif; other site
391896002446	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
391896002447	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
391896002448	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
391896002449	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
391896002450	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
391896002451	carboxyltransferase (CT) interaction site; other site
391896002452	biotinylation site [posttranslational modification]; other site
391896002453	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
391896002454	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
391896002455	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
391896002456	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
391896002457	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896002458	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
391896002459	putative acyl-acceptor binding pocket; other site
391896002460	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
391896002461	acyl-activating enzyme (AAE) consensus motif; other site
391896002462	putative AMP binding site [chemical binding]; other site
391896002463	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
391896002464	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
391896002465	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
391896002466	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391896002467	Coenzyme A binding pocket [chemical binding]; other site
391896002468	Fic family protein [Function unknown]; Region: COG3177
391896002469	Rickettsial palindromic element RPE5 domain; Region: RPE5; TIGR03776
391896002470	Fic/DOC family; Region: Fic; pfam02661
391896002471	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
391896002472	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391896002473	Coenzyme A binding pocket [chemical binding]; other site
391896002474	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
391896002475	glutamyl-tRNA synthetase; Provisional; Region: gltX; PRK14895
391896002476	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
391896002477	HIGH motif; other site
391896002478	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
391896002479	active site
391896002480	KMSKS motif; other site
391896002481	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896002482	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896002483	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896002484	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
391896002485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896002486	S-adenosylmethionine binding site [chemical binding]; other site
391896002487	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
391896002488	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
391896002489	ribosomal protein S21; Region: S21p; TIGR00030
391896002490	Uncharacterized conserved protein [Function unknown]; Region: COG5590
391896002491	COQ9; Region: COQ9; pfam08511
391896002492	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071
391896002493	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144
391896002494	conserved cys residue [active]
391896002495	Methyltransferase domain; Region: Methyltransf_31; pfam13847
391896002496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896002497	S-adenosylmethionine binding site [chemical binding]; other site
391896002498	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
391896002499	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
391896002500	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391896002501	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
391896002502	Predicted permeases [General function prediction only]; Region: COG0679
391896002503	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
391896002504	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
391896002505	catalytic residues [active]
391896002506	catalytic nucleophile [active]
391896002507	Recombinase; Region: Recombinase; pfam07508
391896002508	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391896002509	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
391896002510	active site
391896002511	DNA binding site [nucleotide binding]
391896002512	Int/Topo IB signature motif; other site
391896002513	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
391896002514	Leucine-rich repeats; other site
391896002515	Substrate binding site [chemical binding]; other site
391896002516	TraE protein; Region: TraE; cl05060
391896002517	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
391896002518	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
391896002519	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
391896002520	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
391896002521	Walker A motif; other site
391896002522	ATP binding site [chemical binding]; other site
391896002523	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
391896002524	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
391896002525	TraU protein; Region: TraU; pfam06834
391896002526	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
391896002527	Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; pfam06986
391896002528	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
391896002529	F plasmid transfer operon protein; Region: TraF; pfam13728
391896002530	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
391896002531	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
391896002532	TPR repeat; Region: TPR_11; pfam13414
391896002533	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391896002534	binding surface
391896002535	TPR motif; other site
391896002536	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391896002537	binding surface
391896002538	TPR repeat; Region: TPR_11; pfam13414
391896002539	TPR motif; other site
391896002540	TPR repeat; Region: TPR_11; pfam13414
391896002541	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391896002542	binding surface
391896002543	TPR motif; other site
391896002544	TPR repeat; Region: TPR_11; pfam13414
391896002545	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391896002546	binding surface
391896002547	TPR repeat; Region: TPR_11; pfam13414
391896002548	TPR motif; other site
391896002549	TPR repeat; Region: TPR_11; pfam13414
391896002550	F sex factor protein N terminal; Region: TraD_N; pfam12615
391896002551	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
391896002552	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
391896002553	Walker A motif; other site
391896002554	ATP binding site [chemical binding]; other site
391896002555	Walker B motif; other site
391896002556	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
391896002557	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
391896002558	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
391896002559	MobA/MobL family; Region: MobA_MobL; pfam03389
391896002560	AAA domain; Region: AAA_30; pfam13604
391896002561	Family description; Region: UvrD_C_2; pfam13538
391896002562	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
391896002563	active site
391896002564	metal binding site [ion binding]; metal-binding site
391896002565	interdomain interaction site; other site
391896002566	Conjugal transfer protein TraD; Region: TraD; pfam06412
391896002567	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391896002568	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
391896002569	synthetase active site [active]
391896002570	NTP binding site [chemical binding]; other site
391896002571	metal binding site [ion binding]; metal-binding site
391896002572	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
391896002573	DNA binding residues [nucleotide binding]
391896002574	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391896002575	HD domain; Region: HD_4; pfam13328
391896002576	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391896002577	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
391896002578	dimer interface [polypeptide binding]; other site
391896002579	phosphorylation site [posttranslational modification]
391896002580	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391896002581	ATP binding site [chemical binding]; other site
391896002582	Mg2+ binding site [ion binding]; other site
391896002583	G-X-G motif; other site
391896002584	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
391896002585	DnaA N-terminal domain; Region: DnaA_N; pfam11638
391896002586	cytidylate kinase; Provisional; Region: cmk; PRK00023
391896002587	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
391896002588	CMP-binding site; other site
391896002589	The sites determining sugar specificity; other site
391896002590	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
391896002591	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
391896002592	RNA binding site [nucleotide binding]; other site
391896002593	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
391896002594	RNA binding site [nucleotide binding]; other site
391896002595	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
391896002596	RNA binding site [nucleotide binding]; other site
391896002597	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
391896002598	RNA binding site [nucleotide binding]; other site
391896002599	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
391896002600	RNA binding site [nucleotide binding]; other site
391896002601	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
391896002602	RNA binding site [nucleotide binding]; other site
391896002603	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
391896002604	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
391896002605	oligomer interface [polypeptide binding]; other site
391896002606	active site residues [active]
391896002607	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
391896002608	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
391896002609	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847
391896002610	UbiA prenyltransferase family; Region: UbiA; pfam01040
391896002611	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
391896002612	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
391896002613	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
391896002614	Terminase-like family; Region: Terminase_6; pfam03237
391896002615	Phage-related terminase [General function prediction only]; Region: COG5362
391896002616	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
391896002617	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
391896002618	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
391896002619	NADH dehydrogenase subunit B; Validated; Region: PRK06411
391896002620	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
391896002621	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
391896002622	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
391896002623	NADH dehydrogenase subunit D; Validated; Region: PRK06075
391896002624	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
391896002625	GIY-YIG motif/motif A; other site
391896002626	putative active site [active]
391896002627	putative metal binding site [ion binding]; other site
391896002628	NADH dehydrogenase subunit E; Validated; Region: PRK07539
391896002629	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
391896002630	putative dimer interface [polypeptide binding]; other site
391896002631	[2Fe-2S] cluster binding site [ion binding]; other site
391896002632	Haemolytic domain; Region: Haemolytic; cl00506
391896002633	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
391896002634	active site
391896002635	DNA binding site [nucleotide binding]
391896002636	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
391896002637	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
391896002638	MutS domain I; Region: MutS_I; pfam01624
391896002639	MutS domain II; Region: MutS_II; pfam05188
391896002640	MutS domain III; Region: MutS_III; pfam05192
391896002641	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
391896002642	Walker A/P-loop; other site
391896002643	ATP binding site [chemical binding]; other site
391896002644	Q-loop/lid; other site
391896002645	ABC transporter signature motif; other site
391896002646	Walker B; other site
391896002647	D-loop; other site
391896002648	H-loop/switch region; other site
391896002649	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
391896002650	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391896002651	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391896002652	Walker A/P-loop; other site
391896002653	ATP binding site [chemical binding]; other site
391896002654	Q-loop/lid; other site
391896002655	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391896002656	ABC transporter signature motif; other site
391896002657	Walker B; other site
391896002658	D-loop; other site
391896002659	ABC transporter; Region: ABC_tran_2; pfam12848
391896002660	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391896002661	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
391896002662	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391896002663	Autotransporter beta-domain; Region: Autotransporter; pfam03797
391896002664	AAA domain; Region: AAA_14; pfam13173
391896002665	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391896002666	Mechanosensitive ion channel; Region: MS_channel; pfam00924
391896002667	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391896002668	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391896002669	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391896002670	Walker A/P-loop; other site
391896002671	ATP binding site [chemical binding]; other site
391896002672	Q-loop/lid; other site
391896002673	ABC transporter signature motif; other site
391896002674	Walker B; other site
391896002675	D-loop; other site
391896002676	H-loop/switch region; other site
391896002677	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391896002678	DNA binding residues [nucleotide binding]
391896002679	dimerization interface [polypeptide binding]; other site
391896002680	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
391896002681	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
391896002682	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
391896002683	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
391896002684	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
391896002685	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
391896002686	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
391896002687	GIY-YIG motif/motif A; other site
391896002688	active site
391896002689	catalytic site [active]
391896002690	putative DNA binding site [nucleotide binding]; other site
391896002691	metal binding site [ion binding]; metal-binding site
391896002692	UvrB/uvrC motif; Region: UVR; pfam02151
391896002693	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
391896002694	mce related protein; Region: MCE; pfam02470
391896002695	hypothetical protein; Provisional; Region: PRK06630
391896002696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
391896002697	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494
391896002698	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
391896002699	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
391896002700	CoA-binding site [chemical binding]; other site
391896002701	ATP-binding [chemical binding]; other site
391896002702	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
391896002703	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
391896002704	active site
391896002705	catalytic site [active]
391896002706	substrate binding site [chemical binding]; other site
391896002707	Uncharacterized conserved protein [Function unknown]; Region: COG4278
391896002708	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
391896002709	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
391896002710	Part of AAA domain; Region: AAA_19; pfam13245
391896002711	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
391896002712	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
391896002713	Family description; Region: UvrD_C_2; pfam13538
391896002714	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
391896002715	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896002716	Autotransporter beta-domain; Region: Autotransporter; pfam03797
391896002717	multifunctional aminopeptidase A; Provisional; Region: PRK00913
391896002718	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
391896002719	interface (dimer of trimers) [polypeptide binding]; other site
391896002720	Substrate-binding/catalytic site; other site
391896002721	Zn-binding sites [ion binding]; other site
391896002722	ATPase MipZ; Region: MipZ; pfam09140
391896002723	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
391896002724	P-loop; other site
391896002725	Magnesium ion binding site [ion binding]; other site
391896002726	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
391896002727	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
391896002728	dimer interface [polypeptide binding]; other site
391896002729	anticodon binding site; other site
391896002730	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
391896002731	homodimer interface [polypeptide binding]; other site
391896002732	motif 1; other site
391896002733	active site
391896002734	motif 2; other site
391896002735	GAD domain; Region: GAD; pfam02938
391896002736	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
391896002737	active site
391896002738	motif 3; other site
391896002739	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
391896002740	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896002741	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896002742	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
391896002743	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
391896002744	domain interfaces; other site
391896002745	active site
391896002746	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
391896002747	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
391896002748	dimer interface [polypeptide binding]; other site
391896002749	catalytic triad [active]
391896002750	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
391896002751	Na binding site [ion binding]; other site
391896002752	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391896002753	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391896002754	dimer interface [polypeptide binding]; other site
391896002755	phosphorylation site [posttranslational modification]
391896002756	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391896002757	ATP binding site [chemical binding]; other site
391896002758	Mg2+ binding site [ion binding]; other site
391896002759	G-X-G motif; other site
391896002760	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896002761	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896002762	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896002763	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
391896002764	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
391896002765	tetramerization interface [polypeptide binding]; other site
391896002766	NAD(P) binding site [chemical binding]; other site
391896002767	catalytic residues [active]
391896002768	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
391896002769	metal ion-dependent adhesion site (MIDAS); other site
391896002770	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
391896002771	Glycoprotease family; Region: Peptidase_M22; pfam00814
391896002772	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
391896002773	trimer interface [polypeptide binding]; other site
391896002774	active site
391896002775	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
391896002776	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
391896002777	tandem repeat interface [polypeptide binding]; other site
391896002778	oligomer interface [polypeptide binding]; other site
391896002779	active site residues [active]
391896002780	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
391896002781	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
391896002782	catalytic residues [active]
391896002783	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
391896002784	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
391896002785	active site
391896002786	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896002787	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896002788	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896002789	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
391896002790	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
391896002791	Iron permease FTR1 family; Region: FTR1; cl00475
391896002792	intracellular septation protein A; Reviewed; Region: PRK00259
391896002793	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
391896002794	BON domain; Region: BON; pfam04972
391896002795	BON domain; Region: BON; pfam04972
391896002796	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
391896002797	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
391896002798	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
391896002799	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391896002800	RNA binding surface [nucleotide binding]; other site
391896002801	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
391896002802	active site
391896002803	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
391896002804	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896002805	S-adenosylmethionine binding site [chemical binding]; other site
391896002806	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896002807	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896002808	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896002809	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896002810	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896002811	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896002812	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896002813	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896002814	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896002815	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896002816	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
391896002817	DNA repair protein RadA; Provisional; Region: PRK11823
391896002818	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
391896002819	Walker A motif/ATP binding site; other site
391896002820	ATP binding site [chemical binding]; other site
391896002821	Walker B motif; other site
391896002822	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
391896002823	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
391896002824	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
391896002825	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
391896002826	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
391896002827	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
391896002828	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
391896002829	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
391896002830	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
391896002831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391896002832	active site
391896002833	phosphorylation site [posttranslational modification]
391896002834	intermolecular recognition site; other site
391896002835	dimerization interface [polypeptide binding]; other site
391896002836	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391896002837	Walker A motif; other site
391896002838	ATP binding site [chemical binding]; other site
391896002839	Walker B motif; other site
391896002840	arginine finger; other site
391896002841	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
391896002842	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
391896002843	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
391896002844	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
391896002845	Phage capsid family; Region: Phage_capsid; pfam05065
391896002846	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
391896002847	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
391896002848	oligomerization interface [polypeptide binding]; other site
391896002849	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
391896002850	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
391896002851	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
391896002852	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
391896002853	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
391896002854	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
391896002855	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
391896002856	Predicted membrane protein [Function unknown]; Region: COG5346
391896002857	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
391896002858	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
391896002859	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
391896002860	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
391896002861	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
391896002862	E3 interaction surface; other site
391896002863	lipoyl attachment site [posttranslational modification]; other site
391896002864	e3 binding domain; Region: E3_binding; pfam02817
391896002865	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
391896002866	peptide chain release factor 1; Validated; Region: prfA; PRK00591
391896002867	This domain is found in peptide chain release factors; Region: PCRF; smart00937
391896002868	RF-1 domain; Region: RF-1; pfam00472
391896002869	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
391896002870	DHH family; Region: DHH; pfam01368
391896002871	DHHA1 domain; Region: DHHA1; pfam02272
391896002872	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896002873	Methyltransferase domain; Region: Methyltransf_31; pfam13847
391896002874	S-adenosylmethionine binding site [chemical binding]; other site
391896002875	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
391896002876	Recombination protein O N terminal; Region: RecO_N; pfam11967
391896002877	Recombination protein O C terminal; Region: RecO_C; pfam02565
391896002878	Protein of unknown function (DUF2608); Region: DUF2608; pfam11019
391896002879	isocitrate dehydrogenase; Validated; Region: PRK09222
391896002880	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
391896002881	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
391896002882	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
391896002883	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
391896002884	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
391896002885	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
391896002886	G1 box; other site
391896002887	putative GEF interaction site [polypeptide binding]; other site
391896002888	GTP/Mg2+ binding site [chemical binding]; other site
391896002889	Switch I region; other site
391896002890	G2 box; other site
391896002891	G3 box; other site
391896002892	Switch II region; other site
391896002893	G4 box; other site
391896002894	G5 box; other site
391896002895	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
391896002896	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
391896002897	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896002898	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896002899	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896002900	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391896002901	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391896002902	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
391896002903	Walker A/P-loop; other site
391896002904	ATP binding site [chemical binding]; other site
391896002905	Q-loop/lid; other site
391896002906	ABC transporter signature motif; other site
391896002907	Walker B; other site
391896002908	D-loop; other site
391896002909	H-loop/switch region; other site
391896002910	CAAX protease self-immunity; Region: Abi; pfam02517
391896002911	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
391896002912	Protein of unknown function DUF45; Region: DUF45; pfam01863
391896002913	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
391896002914	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
391896002915	Rickettsial palindromic element RPE3 domain; Region: RPE3; TIGR03775
391896002916	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
391896002917	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896002918	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896002919	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896002920	Autotransporter beta-domain; Region: Autotransporter; smart00869
391896002921	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
391896002922	active site
391896002923	catalytic triad [active]
391896002924	oxyanion hole [active]
391896002925	translocation protein TolB; Provisional; Region: tolB; PRK05137
391896002926	TolB amino-terminal domain; Region: TolB_N; pfam04052
391896002927	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
391896002928	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
391896002929	Gram-negative bacterial tonB protein; Region: TonB; cl10048
391896002930	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
391896002931	TolR protein; Region: tolR; TIGR02801
391896002932	TolQ protein; Region: tolQ; TIGR02796
391896002933	AAA domain; Region: AAA_14; pfam13173
391896002934	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391896002935	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
391896002936	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
391896002937	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896002938	pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212
391896002939	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
391896002940	alpha subunit interface [polypeptide binding]; other site
391896002941	TPP binding site [chemical binding]; other site
391896002942	heterodimer interface [polypeptide binding]; other site
391896002943	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
391896002944	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
391896002945	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
391896002946	tetramer interface [polypeptide binding]; other site
391896002947	TPP-binding site [chemical binding]; other site
391896002948	heterodimer interface [polypeptide binding]; other site
391896002949	phosphorylation loop region [posttranslational modification]
391896002950	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
391896002951	putative catalytic site [active]
391896002952	putative phosphate binding site [ion binding]; other site
391896002953	active site
391896002954	metal binding site A [ion binding]; metal-binding site
391896002955	DNA binding site [nucleotide binding]
391896002956	putative AP binding site [nucleotide binding]; other site
391896002957	putative metal binding site B [ion binding]; other site
391896002958	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
391896002959	Beta-lactamase; Region: Beta-lactamase; pfam00144
391896002960	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
391896002961	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391896002962	RNA binding surface [nucleotide binding]; other site
391896002963	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
391896002964	active site
391896002965	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
391896002966	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
391896002967	Serine hydrolase; Region: Ser_hydrolase; cl17834
391896002968	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
391896002969	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896002970	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896002971	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896002972	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
391896002973	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
391896002974	GIY-YIG motif/motif A; other site
391896002975	active site
391896002976	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
391896002977	RNA binding site [nucleotide binding]; other site
391896002978	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
391896002979	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
391896002980	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391896002981	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896002982	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896002983	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896002984	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896002985	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896002986	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896002987	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
391896002988	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
391896002989	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
391896002990	23S rRNA interface [nucleotide binding]; other site
391896002991	L3 interface [polypeptide binding]; other site
391896002992	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
391896002993	Trp docking motif [polypeptide binding]; other site
391896002994	active site
391896002995	PQQ-like domain; Region: PQQ_2; pfam13360
391896002996	Protein of unknown function (DUF2659); Region: DUF2659; pfam10858
391896002997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
391896002998	Tetratricopeptide repeat; Region: TPR_6; pfam13174
391896002999	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391896003000	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391896003001	dimer interface [polypeptide binding]; other site
391896003002	phosphorylation site [posttranslational modification]
391896003003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391896003004	ATP binding site [chemical binding]; other site
391896003005	Mg2+ binding site [ion binding]; other site
391896003006	G-X-G motif; other site
391896003007	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
391896003008	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
391896003009	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
391896003010	protein binding site [polypeptide binding]; other site
391896003011	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
391896003012	Catalytic dyad [active]
391896003013	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
391896003014	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391896003015	ATP binding site [chemical binding]; other site
391896003016	Mg2+ binding site [ion binding]; other site
391896003017	G-X-G motif; other site
391896003018	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
391896003019	anchoring element; other site
391896003020	dimer interface [polypeptide binding]; other site
391896003021	ATP binding site [chemical binding]; other site
391896003022	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
391896003023	active site
391896003024	metal binding site [ion binding]; metal-binding site
391896003025	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
391896003026	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896003027	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896003028	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
391896003029	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896003030	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896003031	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896003032	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827
391896003033	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
391896003034	Protein of unknown function (DUF2660); Region: DUF2660; pfam10859
391896003035	thymidylate kinase; Validated; Region: tmk; PRK00698
391896003036	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
391896003037	TMP-binding site; other site
391896003038	ATP-binding site [chemical binding]; other site
391896003039	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
391896003040	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
391896003041	HIGH motif; other site
391896003042	active site
391896003043	KMSKS motif; other site
391896003044	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
391896003045	tRNA binding surface [nucleotide binding]; other site
391896003046	anticodon binding site; other site
391896003047	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
391896003048	active site
391896003049	Protein of unknown function (DUF511); Region: DUF511; pfam04373
391896003050	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
391896003051	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
391896003052	Substrate binding site; other site
391896003053	Cupin domain; Region: Cupin_2; cl17218
391896003054	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
391896003055	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
391896003056	DNA binding site [nucleotide binding]
391896003057	catalytic residue [active]
391896003058	H2TH interface [polypeptide binding]; other site
391896003059	putative catalytic residues [active]
391896003060	turnover-facilitating residue; other site
391896003061	intercalation triad [nucleotide binding]; other site
391896003062	8OG recognition residue [nucleotide binding]; other site
391896003063	putative reading head residues; other site
391896003064	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
391896003065	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
391896003066	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
391896003067	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896003068	S-adenosylmethionine binding site [chemical binding]; other site
391896003069	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
391896003070	ABC1 family; Region: ABC1; pfam03109
391896003071	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
391896003072	active site
391896003073	ATP binding site [chemical binding]; other site
391896003074	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391896003075	AAA domain; Region: AAA_14; pfam13173
391896003076	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
391896003077	GTP-binding protein Der; Reviewed; Region: PRK00093
391896003078	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
391896003079	G1 box; other site
391896003080	GTP/Mg2+ binding site [chemical binding]; other site
391896003081	Switch I region; other site
391896003082	G2 box; other site
391896003083	Switch II region; other site
391896003084	G3 box; other site
391896003085	G4 box; other site
391896003086	G5 box; other site
391896003087	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
391896003088	G1 box; other site
391896003089	GTP/Mg2+ binding site [chemical binding]; other site
391896003090	Switch I region; other site
391896003091	G2 box; other site
391896003092	G3 box; other site
391896003093	Switch II region; other site
391896003094	G4 box; other site
391896003095	G5 box; other site
391896003096	Uncharacterized conserved protein [Function unknown]; Region: COG4095
391896003097	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896003098	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896003099	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896003100	SurA N-terminal domain; Region: SurA_N_3; cl07813
391896003101	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
391896003102	Organic solvent tolerance protein; Region: OstA_C; pfam04453
391896003103	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
391896003104	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
391896003105	generic binding surface II; other site
391896003106	generic binding surface I; other site
391896003107	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
391896003108	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391896003109	substrate binding pocket [chemical binding]; other site
391896003110	membrane-bound complex binding site; other site
391896003111	hinge residues; other site
391896003112	Predicted membrane protein [Function unknown]; Region: COG2860
391896003113	UPF0126 domain; Region: UPF0126; pfam03458
391896003114	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
391896003115	putative catalytic site [active]
391896003116	putative phosphate binding site [ion binding]; other site
391896003117	active site
391896003118	metal binding site A [ion binding]; metal-binding site
391896003119	DNA binding site [nucleotide binding]
391896003120	putative AP binding site [nucleotide binding]; other site
391896003121	putative metal binding site B [ion binding]; other site
391896003122	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
391896003123	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896003124	S-adenosylmethionine binding site [chemical binding]; other site
391896003125	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896003126	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896003127	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896003128	Protein of unknown function (DUF2673); Region: DUF2673; pfam10880
391896003129	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
391896003130	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896003131	putative substrate translocation pore; other site
391896003132	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391896003133	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391896003134	Walker A/P-loop; other site
391896003135	ATP binding site [chemical binding]; other site
391896003136	Q-loop/lid; other site
391896003137	ABC transporter signature motif; other site
391896003138	Walker B; other site
391896003139	D-loop; other site
391896003140	H-loop/switch region; other site
391896003141	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
391896003142	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
391896003143	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
391896003144	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
391896003145	nucleotide binding pocket [chemical binding]; other site
391896003146	K-X-D-G motif; other site
391896003147	catalytic site [active]
391896003148	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
391896003149	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
391896003150	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
391896003151	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
391896003152	Dimer interface [polypeptide binding]; other site
391896003153	BRCT sequence motif; other site
391896003154	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
391896003155	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896003156	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
391896003157	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
391896003158	Peptidase family M23; Region: Peptidase_M23; pfam01551
391896003159	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
391896003160	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
391896003161	putative acyl-acceptor binding pocket; other site
391896003162	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
391896003163	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
391896003164	Rickettsia outer membrane protein B; Region: rOmpB; pfam12334
391896003165	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
391896003166	Autotransporter beta-domain; Region: Autotransporter; smart00869
391896003167	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391896003168	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
391896003169	synthetase active site [active]
391896003170	NTP binding site [chemical binding]; other site
391896003171	metal binding site [ion binding]; metal-binding site
391896003172	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
391896003173	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
391896003174	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
391896003175	IHF dimer interface [polypeptide binding]; other site
391896003176	IHF - DNA interface [nucleotide binding]; other site
391896003177	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
391896003178	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
391896003179	catalytic triad [active]
391896003180	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
391896003181	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
391896003182	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391896003183	active site
391896003184	DNA binding site [nucleotide binding]
391896003185	Int/Topo IB signature motif; other site
391896003186	Phasin protein; Region: Phasin_2; pfam09361
391896003187	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
391896003188	PLD-like domain; Region: PLDc_2; pfam13091
391896003189	putative active site [active]
391896003190	catalytic site [active]
391896003191	Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243
391896003192	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
391896003193	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
391896003194	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
391896003195	SurA N-terminal domain; Region: SurA_N_3; cl07813
391896003196	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
391896003197	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
391896003198	Autotransporter beta-domain; Region: Autotransporter; pfam03797
391896003199	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
391896003200	Competence protein; Region: Competence; pfam03772
391896003201	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
391896003202	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
391896003203	active site
391896003204	NTP binding site [chemical binding]; other site
391896003205	metal binding triad [ion binding]; metal-binding site
391896003206	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
391896003207	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
391896003208	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
391896003209	intersubunit interface [polypeptide binding]; other site
391896003210	AAA domain; Region: AAA_14; pfam13173
391896003211	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391896003212	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
391896003213	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
391896003214	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
391896003215	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
391896003216	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
391896003217	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
391896003218	dimer interface [polypeptide binding]; other site
391896003219	ssDNA binding site [nucleotide binding]; other site
391896003220	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391896003221	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
391896003222	Protein of unknown function (DUF721); Region: DUF721; pfam05258
391896003223	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
391896003224	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
391896003225	Mg++ binding site [ion binding]; other site
391896003226	putative catalytic motif [active]
391896003227	putative substrate binding site [chemical binding]; other site
391896003228	hypothetical protein; Reviewed; Region: PRK00024
391896003229	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
391896003230	MPN+ (JAMM) motif; other site
391896003231	Zinc-binding site [ion binding]; other site
391896003232	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
391896003233	active site
391896003234	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391896003235	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391896003236	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391896003237	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
391896003238	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
391896003239	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
391896003240	Sulfatase; Region: Sulfatase; pfam00884
391896003241	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
391896003242	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896003243	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896003244	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896003245	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
391896003246	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391896003247	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
391896003248	rRNA binding site [nucleotide binding]; other site
391896003249	predicted 30S ribosome binding site; other site
391896003250	Maf-like protein; Region: Maf; pfam02545
391896003251	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
391896003252	active site
391896003253	dimer interface [polypeptide binding]; other site
391896003254	TLC ATP/ADP transporter; Region: TLC; pfam03219
391896003255	Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243
391896003256	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
391896003257	acetyl-CoA acetyltransferase; Provisional; Region: PRK06633
391896003258	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
391896003259	dimer interface [polypeptide binding]; other site
391896003260	active site
391896003261	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
391896003262	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
391896003263	putative active site [active]
391896003264	Part of AAA domain; Region: AAA_19; pfam13245
391896003265	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
391896003266	AAA domain; Region: AAA_12; pfam13087
391896003267	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
391896003268	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
391896003269	catalytic site [active]
391896003270	G-X2-G-X-G-K; other site
391896003271	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391896003272	sequence-specific DNA binding site [nucleotide binding]; other site
391896003273	salt bridge; other site
391896003274	rod shape-determining protein MreC; Provisional; Region: PRK13922
391896003275	rod shape-determining protein MreC; Region: MreC; pfam04085
391896003276	rod shape-determining protein MreB; Provisional; Region: PRK13927
391896003277	MreB and similar proteins; Region: MreB_like; cd10225
391896003278	nucleotide binding site [chemical binding]; other site
391896003279	Mg binding site [ion binding]; other site
391896003280	putative protofilament interaction site [polypeptide binding]; other site
391896003281	RodZ interaction site [polypeptide binding]; other site
391896003282	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
391896003283	Predicted permeases [General function prediction only]; Region: COG0795
391896003284	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
391896003285	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
391896003286	ligand binding site [chemical binding]; other site
391896003287	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
391896003288	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
391896003289	dimer interface [polypeptide binding]; other site
391896003290	active site
391896003291	CoA binding pocket [chemical binding]; other site
391896003292	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
391896003293	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
391896003294	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
391896003295	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391896003296	TPR motif; other site
391896003297	binding surface
391896003298	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391896003299	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391896003300	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391896003301	DNA binding site [nucleotide binding]
391896003302	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
391896003303	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
391896003304	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
391896003305	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
391896003306	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
391896003307	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
391896003308	recombinase A; Provisional; Region: recA; PRK09354
391896003309	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
391896003310	hexamer interface [polypeptide binding]; other site
391896003311	Walker A motif; other site
391896003312	ATP binding site [chemical binding]; other site
391896003313	Walker B motif; other site
391896003314	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
391896003315	NAD(P) binding site [chemical binding]; other site
391896003316	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
391896003317	homotetramer interface [polypeptide binding]; other site
391896003318	homodimer interface [polypeptide binding]; other site
391896003319	active site
391896003320	acyl carrier protein; Provisional; Region: acpP; PRK00982
391896003321	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
391896003322	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
391896003323	dimer interface [polypeptide binding]; other site
391896003324	active site
391896003325	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
391896003326	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391896003327	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391896003328	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
391896003329	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
391896003330	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391896003331	FeS/SAM binding site; other site
391896003332	TRAM domain; Region: TRAM; pfam01938
391896003333	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
391896003334	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
391896003335	Transglycosylase; Region: Transgly; pfam00912
391896003336	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
391896003337	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
391896003338	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
391896003339	DNA photolyase; Region: DNA_photolyase; pfam00875
391896003340	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391896003341	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391896003342	Walker A motif; other site
391896003343	ATP binding site [chemical binding]; other site
391896003344	Walker B motif; other site
391896003345	arginine finger; other site
391896003346	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
391896003347	4Fe-4S binding domain; Region: Fer4; cl02805
391896003348	4Fe-4S binding domain; Region: Fer4; pfam00037
391896003349	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
391896003350	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
391896003351	NADH dehydrogenase subunit G; Validated; Region: PRK09130
391896003352	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
391896003353	catalytic loop [active]
391896003354	iron binding site [ion binding]; other site
391896003355	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
391896003356	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
391896003357	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
391896003358	Predicted membrane protein [Function unknown]; Region: COG3671
391896003359	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
391896003360	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
391896003361	aconitate hydratase; Validated; Region: PRK09277
391896003362	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
391896003363	substrate binding site [chemical binding]; other site
391896003364	ligand binding site [chemical binding]; other site
391896003365	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
391896003366	substrate binding site [chemical binding]; other site
391896003367	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK01474
391896003368	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
391896003369	gamma subunit interface [polypeptide binding]; other site
391896003370	epsilon subunit interface [polypeptide binding]; other site
391896003371	LBP interface [polypeptide binding]; other site
391896003372	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
391896003373	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
391896003374	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
391896003375	alpha subunit interaction interface [polypeptide binding]; other site
391896003376	Walker A motif; other site
391896003377	ATP binding site [chemical binding]; other site
391896003378	Walker B motif; other site
391896003379	inhibitor binding site; inhibition site
391896003380	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
391896003381	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
391896003382	core domain interface [polypeptide binding]; other site
391896003383	delta subunit interface [polypeptide binding]; other site
391896003384	epsilon subunit interface [polypeptide binding]; other site
391896003385	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
391896003386	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
391896003387	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
391896003388	beta subunit interaction interface [polypeptide binding]; other site
391896003389	Walker A motif; other site
391896003390	ATP binding site [chemical binding]; other site
391896003391	Walker B motif; other site
391896003392	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
391896003393	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
391896003394	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
391896003395	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
391896003396	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391896003397	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391896003398	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
391896003399	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
391896003400	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
391896003401	dimerization interface [polypeptide binding]; other site
391896003402	DPS ferroxidase diiron center [ion binding]; other site
391896003403	ion pore; other site
391896003404	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13541
391896003405	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391896003406	Walker A/P-loop; other site
391896003407	ATP binding site [chemical binding]; other site
391896003408	Q-loop/lid; other site
391896003409	ABC transporter signature motif; other site
391896003410	Walker B; other site
391896003411	D-loop; other site
391896003412	H-loop/switch region; other site
391896003413	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
391896003414	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
391896003415	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
391896003416	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
391896003417	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
391896003418	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
391896003419	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
391896003420	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
391896003421	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
391896003422	Methyltransferase domain; Region: Methyltransf_31; pfam13847
391896003423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896003424	S-adenosylmethionine binding site [chemical binding]; other site
391896003425	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
391896003426	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
391896003427	Integral membrane protein TerC family; Region: TerC; cl10468
391896003428	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
391896003429	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
391896003430	seryl-tRNA synthetase; Provisional; Region: PRK05431
391896003431	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
391896003432	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
391896003433	dimer interface [polypeptide binding]; other site
391896003434	active site
391896003435	motif 1; other site
391896003436	motif 2; other site
391896003437	motif 3; other site
391896003438	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
391896003439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896003440	putative substrate translocation pore; other site
391896003441	Protein of unknown function; Region: DUF3971; pfam13116
391896003442	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
391896003443	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
391896003444	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
391896003445	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
391896003446	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
391896003447	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
391896003448	putative active site [active]
391896003449	putative PHP Thumb interface [polypeptide binding]; other site
391896003450	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
391896003451	generic binding surface I; other site
391896003452	generic binding surface II; other site
391896003453	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
391896003454	Protein of unknown function (DUF2748); Region: DUF2748; pfam10871
391896003455	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
391896003456	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391896003457	NAD(P) binding site [chemical binding]; other site
391896003458	active site
391896003459	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391896003460	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
391896003461	Clp amino terminal domain; Region: Clp_N; pfam02861
391896003462	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391896003463	Walker A motif; other site
391896003464	ATP binding site [chemical binding]; other site
391896003465	Walker B motif; other site
391896003466	arginine finger; other site
391896003467	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
391896003468	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391896003469	Walker A motif; other site
391896003470	ATP binding site [chemical binding]; other site
391896003471	Walker B motif; other site
391896003472	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
391896003473	PemK-like protein; Region: PemK; pfam02452
391896003474	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
391896003475	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391896003476	non-specific DNA binding site [nucleotide binding]; other site
391896003477	salt bridge; other site
391896003478	sequence-specific DNA binding site [nucleotide binding]; other site
391896003479	Methyltransferase domain; Region: Methyltransf_31; pfam13847
391896003480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391896003481	S-adenosylmethionine binding site [chemical binding]; other site
391896003482	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
391896003483	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
391896003484	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
391896003485	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
391896003486	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391896003487	metabolite-proton symporter; Region: 2A0106; TIGR00883
391896003488	putative substrate translocation pore; other site
391896003489	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391896003490	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
391896003491	NAD(P) binding site [chemical binding]; other site
391896003492	active site
391896003493	Zinc-finger domain; Region: zf-CHCC; cl01821
391896003494	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
391896003495	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391896003496	ATP binding site [chemical binding]; other site
391896003497	Mg2+ binding site [ion binding]; other site
391896003498	G-X-G motif; other site
391896003499	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
391896003500	ATP binding site [chemical binding]; other site
391896003501	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
391896003502	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
391896003503	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
391896003504	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
391896003505	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
391896003506	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
391896003507	cofactor binding site; other site
391896003508	DNA binding site [nucleotide binding]
391896003509	substrate interaction site [chemical binding]; other site
391896003510	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
391896003511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391896003512	Walker A motif; other site
391896003513	ATP binding site [chemical binding]; other site
391896003514	Walker B motif; other site
391896003515	arginine finger; other site
391896003516	Peptidase family M41; Region: Peptidase_M41; pfam01434
391896003517	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
391896003518	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
391896003519	Ligand Binding Site [chemical binding]; other site
391896003520	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
391896003521	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
391896003522	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
391896003523	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
391896003524	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
391896003525	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
391896003526	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
391896003527	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
391896003528	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
391896003529	aspartate kinase; Reviewed; Region: PRK06635
391896003530	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
391896003531	putative nucleotide binding site [chemical binding]; other site
391896003532	putative catalytic residues [active]
391896003533	putative Mg ion binding site [ion binding]; other site
391896003534	putative aspartate binding site [chemical binding]; other site
391896003535	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
391896003536	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
391896003537	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
391896003538	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
391896003539	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
391896003540	aromatic arch; other site
391896003541	DCoH dimer interaction site [polypeptide binding]; other site
391896003542	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
391896003543	DCoH tetramer interaction site [polypeptide binding]; other site
391896003544	substrate binding site [chemical binding]; other site
391896003545	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
391896003546	cofactor binding site; other site
391896003547	metal binding site [ion binding]; metal-binding site
391896003548	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
391896003549	tetramer interfaces [polypeptide binding]; other site
391896003550	binuclear metal-binding site [ion binding]; other site
391896003551	twin arginine translocase protein A; Provisional; Region: tatA; PRK01470
391896003552	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
391896003553	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391896003554	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
391896003555	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
391896003556	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
391896003557	putative ligand binding site [chemical binding]; other site
391896003558	Predicted methyltransferases [General function prediction only]; Region: COG0313
391896003559	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
391896003560	putative SAM binding site [chemical binding]; other site
391896003561	putative homodimer interface [polypeptide binding]; other site
391896003562	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
391896003563	Predicted small secreted protein [Function unknown]; Region: COG5510
391896003564	Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004
391896003565	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
391896003566	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
391896003567	Methyltransferase domain; Region: Methyltransf_26; pfam13659
391896003568	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
391896003569	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
391896003570	metal binding site [ion binding]; metal-binding site
391896003571	dimer interface [polypeptide binding]; other site
391896003572	DNA polymerase III subunit chi; Provisional; Region: PRK06646
391896003573	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
391896003574	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
391896003575	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
391896003576	substrate binding site [chemical binding]; other site
391896003577	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
391896003578	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
391896003579	Cation efflux family; Region: Cation_efflux; cl00316
391896003580	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
391896003581	nucleoside/Zn binding site; other site
391896003582	dimer interface [polypeptide binding]; other site
391896003583	catalytic motif [active]
391896003584	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
391896003585	ferrochelatase; Reviewed; Region: hemH; PRK00035
391896003586	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
391896003587	C-terminal domain interface [polypeptide binding]; other site
391896003588	active site
391896003589	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
391896003590	active site
391896003591	N-terminal domain interface [polypeptide binding]; other site
391896003592	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
391896003593	substrate binding site [chemical binding]; other site
391896003594	active site