-- dump date   	20140620_033654
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_001491739.1	COG1806 Uncharacterized protein conserved in bacteria
YP_001491740.1	COG0526 Thiol-disulfide isomerase and thioredoxins
YP_001491741.1	COG1129 ABC-type sugar transport system, ATPase component
YP_001491743.1	undetermined function
YP_001491744.1	catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis
YP_001491745.1	in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP
YP_001491746.1	adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis
YP_001491747.1	COG0042 tRNA-dihydrouridine synthase
YP_001491748.1	COG0802 Predicted ATPase or kinase
YP_001491749.1	COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin
YP_001491750.1	COG0617 tRNA nucleotidyltransferase/poly(A) polymerase
YP_001491754.1	COG0658 Predicted membrane metal-binding protein
YP_001491755.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_001491756.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B' is part of the membrane proton channel.
YP_001491757.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_001491758.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_001491759.1	COG5336 Uncharacterized protein conserved in bacteria
YP_001491760.1	COG1651 Protein-disulfide isomerase
YP_001491761.1	COG1329 Transcriptional regulators, similar to M. xanthus CarD
YP_001491762.1	COG0500 SAM-dependent methyltransferases
YP_001491763.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_001491765.1	COG1195 Recombinational DNA repair ATPase (RecF pathway)
YP_001491766.1	COG1678 Putative transcriptional regulator
YP_001491770.1	COG1286 Uncharacterized membrane protein, required for colicin V production
YP_001491772.1	COG0542 ATPases with chaperone activity, ATP-binding subunit
YP_001491773.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_001491774.1	COG1398 Fatty-acid desaturase
YP_001491775.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_001491776.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_001491777.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_001491778.1	COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
YP_001491779.1	COG0465 ATP-dependent Zn proteases
YP_001491780.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase
YP_001491781.1	COG1565 Uncharacterized conserved protein
YP_001491782.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_001491783.1	COG0668 Small-conductance mechanosensitive channel
YP_001491784.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_001491787.1	COG0558 Phosphatidylglycerophosphate synthase
YP_001491788.1	COG3202 ATP/ADP translocase
YP_001491789.1	COG2271 Sugar phosphate permease
YP_001491790.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_001491791.1	GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs
YP_001491792.1	COG1192 ATPases involved in chromosome partitioning
YP_001491793.1	COG1475 Predicted transcriptional regulators
YP_001491794.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_001491795.1	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
YP_001491796.1	catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis
YP_001491797.1	COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase
YP_001491798.1	COG0316 Uncharacterized conserved protein
YP_001491799.1	dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate
YP_001491800.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_001491801.1	COG0018 Arginyl-tRNA synthetase
YP_001491802.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_001491803.1	COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
YP_001491804.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_001491805.1	molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA
YP_001491806.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
YP_001491807.1	catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis
YP_001491808.1	COG3820 Uncharacterized protein conserved in bacteria
YP_001491810.1	COG1282 NAD/NADP transhydrogenase beta subunit
YP_001491811.1	COG3047 Outer membrane protein W
YP_001491812.1	COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily
YP_001491814.1	COG0477 Permeases of the major facilitator superfamily
YP_001491816.1	COG1738 Uncharacterized conserved protein
YP_001491817.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_001491818.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_001491819.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_001491820.1	catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A
YP_001491821.1	COG2121 Uncharacterized protein conserved in bacteria
YP_001491822.1	catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate
YP_001491823.1	COG0457 FOG: TPR repeat
YP_001491824.1	COG2853 Surface lipoprotein
YP_001491825.1	COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component
YP_001491826.1	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_001491827.1	COG0767 ABC-type transport system involved in resistance to organic solvents, permease component
YP_001491829.1	COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component
YP_001491830.1	required for 70S ribosome assembly
YP_001491831.1	RpmE; RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_001491832.1	binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential
YP_001491833.1	COG0218 Predicted GTPase
YP_001491834.1	COG3702 Type IV secretory pathway, VirB3 components
YP_001491835.1	COG3451 Type IV secretory pathway, VirB4 components
YP_001491836.1	COG3704 Type IV secretory pathway, VirB6 components
YP_001491837.1	COG3704 Type IV secretory pathway, VirB6 components
YP_001491838.1	COG3704 Type IV secretory pathway, VirB6 components
YP_001491839.1	COG3704 Type IV secretory pathway, VirB6 components
YP_001491844.1	COG0280 Phosphotransacetylase
YP_001491845.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_001491846.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_001491847.1	COG3750 Uncharacterized protein conserved in bacteria
YP_001491848.1	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_001491849.1	part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase
YP_001491850.1	COG0681 Signal peptidase I
YP_001491851.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_001491852.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_001491853.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_001491854.1	COG0565 rRNA methylase
YP_001491855.1	COG3660 Predicted nucleoside-diphosphate-sugar epimerase
YP_001491856.1	COG0489 ATPases involved in chromosome partitioning
YP_001491857.1	COG0330 Membrane protease subunits, stomatin/prohibitin homologs
YP_001491858.1	COG0330 Membrane protease subunits, stomatin/prohibitin homologs
YP_001491859.1	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YP_001491860.1	COG1054 Predicted sulfurtransferase
YP_001491862.1	COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit
YP_001491863.1	COG2142 Succinate dehydrogenase, hydrophobic anchor subunit
YP_001491864.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_001491865.1	COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
YP_001491866.1	COG0765 ABC-type amino acid transport system, permease component
YP_001491867.1	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_001491868.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_001491869.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_001491870.1	forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_001491871.1	Modulates Rho-dependent transcription termination
YP_001491872.1	binds directly to 23S ribosomal RNA
YP_001491873.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_001491874.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_001491875.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_001491876.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_001491877.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_001491878.1	COG0086 DNA-directed RNA polymerase, beta' subunit/160 kD subunit
YP_001491879.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_001491881.1	COG1192 ATPases involved in chromosome partitioning
YP_001491882.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_001491883.1	COG0670 Integral membrane protein, interacts with FtsH
YP_001491884.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_001491885.1	COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family
YP_001491887.1	COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain
YP_001491888.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_001491889.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_001491890.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain
YP_001491891.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_001491892.1	Catalyzes the phosphorylation of UMP to UDP
YP_001491893.1	subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali
YP_001491894.1	COG0477 Permeases of the major facilitator superfamily
YP_001491895.1	COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes
YP_001491896.1	COG4775 Outer membrane protein/protective antigen OMA87
YP_001491897.1	COG0750 Predicted membrane-associated Zn-dependent proteases 1
YP_001491898.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_001491901.1	COG0293 23S rRNA methylase
YP_001491902.1	COG2867 Oligoketide cyclase/lipid transport protein
YP_001491903.1	catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway
YP_001491905.1	COG2171 Tetrahydrodipicolinate N-succinyltransferase
YP_001491906.1	COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3
YP_001491907.1	COG2941 Ubiquinone biosynthesis protein COQ7
YP_001491908.1	required for the assembly and function of the DNAX complex which are required for the assembly of the beta subunit onto primed DNA
YP_001491911.1	COG1466 DNA polymerase III, delta subunit
YP_001491912.1	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YP_001491913.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_001491914.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_001491915.1	COG4572 Putative cation transport regulator
YP_001491916.1	COG4105 DNA uptake lipoprotein
YP_001491917.1	COG0497 ATPase involved in DNA repair
YP_001491918.1	COG2317 Zn-dependent carboxypeptidase
YP_001491919.1	SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide
YP_001491920.1	component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA
YP_001491921.1	COG0720 6-pyruvoyl-tetrahydropterin synthase
YP_001491922.1	COG1324 Uncharacterized protein involved in tolerance to divalent cations
YP_001491925.1	COG1301 Na+/H+-dicarboxylate symporters
YP_001491926.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_001491927.1	COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases
YP_001491928.1	COG0541 Signal recognition particle GTPase
YP_001491929.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_001491930.1	COG0776 Bacterial nucleoid DNA-binding protein
YP_001491931.1	COG0841 Cation/multidrug efflux pump
YP_001491932.1	COG2155 Uncharacterized conserved protein
YP_001491933.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_001491936.1	COG1385 Uncharacterized protein conserved in bacteria
YP_001491937.1	COG0589 Universal stress protein UspA and related nucleotide-binding proteins
YP_001491939.1	COG2358 TRAP-type uncharacterized transport system, periplasmic component
YP_001491940.1	COG0633 Ferredoxin
YP_001491941.1	involved in the maturation of iron-sulfur cluster-containing proteins
YP_001491942.1	J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins
YP_001491943.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_001491944.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_001491945.1	COG0695 Glutaredoxin and related proteins
YP_001491948.1	COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components
YP_001491949.1	COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)
YP_001491950.1	COG3346 Uncharacterized conserved protein
YP_001491951.1	3'-5' exonuclease of DNA polymerase III
YP_001491952.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis
YP_001491953.1	COG3494 Uncharacterized protein conserved in bacteria
YP_001491954.1	COG3814 Uncharacterized protein conserved in bacteria
YP_001491955.1	An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids
YP_001491956.1	COG3761 NADH:ubiquinone oxidoreductase 17.2 kD subunit
YP_001491964.1	COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component
YP_001491966.1	COG0331 (acyl-carrier-protein) S-malonyltransferase
YP_001491967.1	negatively supercoils closed circular double-stranded DNA
YP_001491969.1	COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
YP_001491970.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_001491971.1	modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth
YP_001491972.1	COG0223 Methionyl-tRNA formyltransferase
YP_001491973.1	COG1485 Predicted ATPase
YP_001491974.1	COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase)
YP_001491976.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_001491977.1	COG1271 Cytochrome bd-type quinol oxidase, subunit 1
YP_001491978.1	COG1294 Cytochrome bd-type quinol oxidase, subunit 2
YP_001491979.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_001491980.1	COG0612 Predicted Zn-dependent peptidases
YP_001491981.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_001491982.1	COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase
YP_001491983.1	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr)
YP_001491987.1	COG0441 Threonyl-tRNA synthetase
YP_001491988.1	COG1943 Transposase and inactivated derivatives
YP_001491989.1	COG1943 Transposase and inactivated derivatives
YP_001491991.1	COG1538 Outer membrane protein
YP_001491993.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_001491994.1	COG0793 Periplasmic protease
YP_001491995.1	COG0642 Signal transduction histidine kinase
YP_001491997.1	COG1729 Uncharacterized protein conserved in bacteria
YP_001491998.1	COG1520 FOG: WD40-like repeat
YP_001491999.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_001492000.1	forms a direct contact with the tRNA during translation
YP_001492001.1	COG2173 D-alanyl-D-alanine dipeptidase
YP_001492002.1	COG2154 Pterin-4a-carbinolamine dehydratase
YP_001492003.1	hydrolyzes diadenosine polyphosphate
YP_001492004.1	involved in swarmer-to-stalked cell differentiation in Caulobacter crescentus; catalyzes the condensation of two GTP molecules to form the secondary messenger cyclic di-GMP (c-di-GMP); upon phosphorylation of domain D1 the protein dimerizes; presumably this allows the two GTP-bound GGDEF (diguanylate cyclase) domains to catalyze the condensation reaction; allosterically inhibited by c-di-GMP
YP_001492005.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_001492006.1	COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family
YP_001492007.1	COG0012 Predicted GTPase, probable translation factor
YP_001492008.1	catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine
YP_001492009.1	COG1183 Phosphatidylserine synthase
YP_001492011.1	COG1566 Multidrug resistance efflux pump
YP_001492012.1	COG0271 Stress-induced morphogen (activity unknown)
YP_001492013.1	COG2200 FOG: EAL domain
YP_001492014.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_001492015.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_001492016.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_001492017.1	COG1589 Cell division septal protein
YP_001492020.1	COG0849 Actin-like ATPase involved in cell division
YP_001492022.1	COG3474 Cytochrome c2
YP_001492023.1	zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis
YP_001492024.1	COG0774 UDP-3-O-acyl-N-acetylglucosamine deacetylase
YP_001492025.1	COG1530 Ribonucleases G and E
YP_001492026.1	COG1612 Uncharacterized protein required for cytochrome oxidase assembly
YP_001492027.1	COG0564 Pseudouridylate synthases, 23S RNA-specific
YP_001492028.1	COG1680 Beta-lactamase class C and other penicillin binding proteins
YP_001492029.1	COG0708 Exonuclease III
YP_001492030.1	COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
YP_001492031.1	catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acyltransferase within the complex. The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2); it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase
YP_001492034.1	COG1217 Predicted membrane GTPase involved in stress response
YP_001492035.1	COG2825 Outer membrane protein
YP_001492036.1	catalyzes the formation of 2-oxoglutarate from isocitrate
YP_001492037.1	subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport
YP_001492038.1	subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali
YP_001492040.1	COG1563 Predicted subunit of the Multisubunit Na+/H+ antiporter
YP_001492041.1	COG0723 Rieske Fe-S protein
YP_001492042.1	COG1290 Cytochrome b subunit of the bc complex
YP_001492043.1	COG2857 Cytochrome c1
YP_001492044.1	COG0071 Molecular chaperone (small heat shock protein)
YP_001492045.1	recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1
YP_001492046.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_001492047.1	COG0481 Membrane GTPase LepA
YP_001492048.1	COG0593 ATPase involved in DNA replication initiation
YP_001492049.1	COG0628 Predicted permease
YP_001492050.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_001492051.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_001492052.1	COG1215 Glycosyltransferases, probably involved in cell wall biogenesis
YP_001492053.1	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_001492054.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_001492055.1	COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases
YP_001492056.1	COG5342 Invasion protein B, involved in pathogenesis
YP_001492057.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_001492058.1	Involved in ubiquinone biosynthesis
YP_001492059.1	COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components
YP_001492060.1	Synthesizes thioester adducts of fatty acids enzymatically to the phosphopantetheine group of acyl carrier protein
YP_001492061.1	COG0477 Permeases of the major facilitator superfamily
YP_001492064.1	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
YP_001492066.1	COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit
YP_001492067.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin)
YP_001492068.1	COG5590 Uncharacterized conserved protein
YP_001492069.1	a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA
YP_001492070.1	COG0828 Ribosomal protein S21
YP_001492071.1	COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation
YP_001492076.1	COG0666 FOG: Ankyrin repeat
YP_001492077.1	protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_001492078.1	in Escherichia coli transcription of this gene is enhanced by polyamines
YP_001492079.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_001492080.1	COG0291 Ribosomal protein L35
YP_001492081.1	COG0602 Organic radical activating enzymes
YP_001492082.1	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_001492083.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_001492084.1	COG0193 Peptidyl-tRNA hydrolase
YP_001492085.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_001492095.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_001492099.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_001492101.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_001492102.1	COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase
YP_001492103.1	COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit
YP_001492104.1	COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit
YP_001492107.1	COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit
YP_001492108.1	COG1200 RecG-like helicase
YP_001492110.1	COG1135 ABC-type metal ion transport system, ATPase component
YP_001492112.1	COG0728 Uncharacterized membrane protein, putative virulence factor
YP_001492113.1	catalyzes the hydrolysis of pyrophosphate to phosphate
YP_001492114.1	CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane
YP_001492115.1	COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems
YP_001492116.1	part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane
YP_001492117.1	member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex
YP_001492119.1	COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain)
YP_001492121.1	COG1943 Transposase and inactivated derivatives
YP_001492122.1	COG0647 Predicted sugar phosphatases of the HAD superfamily
YP_001492123.1	negatively supercoils closed circular double-stranded DNA
YP_001492124.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_001492125.1	Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_001492126.1	Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids
YP_001492127.1	COG0760 Parvulin-like peptidyl-prolyl isomerase
YP_001492128.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_001492129.1	COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase)
YP_001492132.1	COG0666 FOG: Ankyrin repeat
YP_001492133.1	COG0286 Type I restriction-modification system methyltransferase subunit
YP_001492135.1	COG0286 Type I restriction-modification system methyltransferase subunit
YP_001492136.1	COG0591 Na+/proline symporter
YP_001492137.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_001492139.1	COG2847 Uncharacterized protein conserved in bacteria
YP_001492140.1	COG0350 Methylated DNA-protein cysteine methyltransferase
YP_001492141.1	COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
YP_001492142.1	MraZ; UPF0040; crystal structure shows similarity to AbrB
YP_001492143.1	COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis
YP_001492144.1	COG5462 Predicted secreted (periplasmic) protein
YP_001492146.1	COG0768 Cell division protein FtsI/penicillin-binding protein 2
YP_001492150.1	COG0768 Cell division protein FtsI/penicillin-binding protein 2
YP_001492151.1	COG1357 Uncharacterized low-complexity proteins
YP_001492152.1	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains
YP_001492153.1	subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali
YP_001492154.1	Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone
YP_001492160.1	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YP_001492161.1	COG0477 Permeases of the major facilitator superfamily
YP_001492166.1	COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases
YP_001492167.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_001492168.1	COG0162 Tyrosyl-tRNA synthetase
YP_001492169.1	COG1189 Predicted rRNA methylase
YP_001492170.1	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins
YP_001492171.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_001492172.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_001492173.1	COG0532 Translation initiation factor 2 (IF-2; GTPase)
YP_001492174.1	COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone
YP_001492175.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_001492176.1	COG0191 Fructose/tagatose bisphosphate aldolase
YP_001492177.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_001492178.1	COG0742 N6-adenine-specific methylase
YP_001492179.1	COG1357 Uncharacterized low-complexity proteins
YP_001492180.1	COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases
YP_001492182.1	COG0814 Amino acid permeases
YP_001492183.1	unwinds double stranded DNA
YP_001492184.1	COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase
YP_001492185.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_001492186.1	COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase
YP_001492187.1	catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_001492188.1	COG0113 Delta-aminolevulinic acid dehydratase
YP_001492189.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001492191.1	COG1007 NADH:ubiquinone oxidoreductase subunit 2 (chain N)
YP_001492195.1	COG1943 Transposase and inactivated derivatives
YP_001492196.1	COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes
YP_001492197.1	catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis
YP_001492198.1	COG0822 NifU homolog involved in Fe-S cluster formation
YP_001492199.1	COG0316 Uncharacterized conserved protein
YP_001492200.1	COG0531 Amino acid transporters
YP_001492201.1	COG0006 Xaa-Pro aminopeptidase
YP_001492203.1	COG0142 Geranylgeranyl pyrophosphate synthase
YP_001492204.1	COG3202 ATP/ADP translocase
YP_001492205.1	COG1943 Transposase and inactivated derivatives
YP_001492206.1	COG0477 Permeases of the major facilitator superfamily
YP_001492209.1	COG1279 Lysine efflux permease
YP_001492210.1	COG0457 FOG: TPR repeat
YP_001492212.1	COG2945 Predicted hydrolase of the alpha/beta superfamily
YP_001492213.1	COG5622 Protein required for attachment to host cells
YP_001492214.1	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase
YP_001492215.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001492216.1	COG0180 Tryptophanyl-tRNA synthetase
YP_001492217.1	transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis
YP_001492221.1	COG0181 Porphobilinogen deaminase
YP_001492223.1	COG0642 Signal transduction histidine kinase
YP_001492224.1	COG0354 Predicted aminomethyltransferase related to GcvT
YP_001492225.1	COG1723 Uncharacterized conserved protein
YP_001492226.1	COG0349 Ribonuclease D
YP_001492227.1	COG0212 5-formyltetrahydrofolate cyclo-ligase
YP_001492228.1	Catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_001492230.1	COG0500 SAM-dependent methyltransferases
YP_001492233.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif
YP_001492234.1	COG0217 Uncharacterized conserved protein
YP_001492237.1	COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)
YP_001492239.1	COG1694 Predicted pyrophosphatase
YP_001492240.1	catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate
YP_001492242.1	COG0474 Cation transport ATPase
YP_001492243.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_001492244.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_001492245.1	Catalyzes the formation of (d)CDP from ATP and (d)CMP
YP_001492248.1	COG0283 Cytidylate kinase
YP_001492249.1	COG2801 Transposase and inactivated derivatives
YP_001492251.1	COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases
YP_001492259.1	COG0477 Permeases of the major facilitator superfamily
YP_001492262.1	COG0358 DNA primase (bacterial type)
YP_001492273.1	COG0457 FOG: TPR repeat
YP_001492274.1	COG0776 Bacterial nucleoid DNA-binding protein
YP_001492275.1	COG0616 Periplasmic serine proteases (ClpP class)
YP_001492276.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_001492277.1	COG0500 SAM-dependent methyltransferases
YP_001492278.1	COG0608 Single-stranded DNA-specific exonuclease
YP_001492279.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_001492280.1	COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes
YP_001492281.1	IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits
YP_001492285.1	COG5346 Predicted membrane protein
YP_001492287.1	COG0340 Biotin-(acetyl-CoA carboxylase) ligase
YP_001492288.1	COG0605 Superoxide dismutase
YP_001492289.1	COG0285 Folylpolyglutamate synthase
YP_001492292.1	COG4285 Uncharacterized conserved protein
YP_001492293.1	COG0625 Glutathione S-transferase
YP_001492294.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_001492301.1	COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase
YP_001492302.1	COG1496 Uncharacterized conserved protein
YP_001492303.1	COG0174 Glutamine synthetase
YP_001492304.1	COG1295 Predicted membrane protein
YP_001492306.1	COG1396 Predicted transcriptional regulators
YP_001492307.1	COG3202 ATP/ADP translocase
YP_001492308.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_001492309.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_001492310.1	COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)
YP_001492311.1	COG0794 Predicted sugar phosphate isomerase involved in capsule formation
YP_001492312.1	COG5375 Uncharacterized protein conserved in bacteria
YP_001492313.1	COG1934 Uncharacterized protein conserved in bacteria
YP_001492314.1	COG1137 ABC-type (unclassified) transport system, ATPase component
YP_001492315.1	COG1109 Phosphomannomutase
YP_001492316.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_001492317.1	COG0593 ATPase involved in DNA replication initiation
YP_001492318.1	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE
YP_001492319.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_001492321.1	COG0209 Ribonucleotide reductase, alpha subunit
YP_001492322.1	COG0492 Thioredoxin reductase
YP_001492323.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_001492325.1	COG1544 Ribosome-associated protein Y (PSrp-1)
YP_001492327.1	COG5525 Bacteriophage tail assembly protein
YP_001492328.1	COG0466 ATP-dependent Lon protease, bacterial type
YP_001492329.1	catalyzes the formation of 2-oxobutanoate from L-threonine
YP_001492330.1	COG1137 ABC-type (unclassified) transport system, ATPase component
YP_001492331.1	COG1038 Pyruvate carboxylase
YP_001492332.1	COG0210 Superfamily I DNA and RNA helicases
YP_001492334.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_001492335.1	COG1012 NAD-dependent aldehyde dehydrogenases
YP_001492336.1	COG1943 Transposase and inactivated derivatives
YP_001492339.1	COG1943 Transposase and inactivated derivatives
YP_001492340.1	COG0492 Thioredoxin reductase
YP_001492341.1	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)
YP_001492344.1	COG0679 Predicted permeases
YP_001492345.1	COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily
YP_001492346.1	catalyzes the phosphorylation of NAD to NADP
YP_001492349.1	COG0061 Predicted sugar kinase
YP_001492350.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_001492351.1	COG1714 Predicted membrane protein/domain
YP_001492352.1	COG1238 Predicted membrane protein
YP_001492353.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_001492354.1	COG4395 Uncharacterized protein conserved in bacteria
YP_001492355.1	COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases
YP_001492356.1	catalyzes the interconversion of succinyl-CoA and succinate
YP_001492357.1	Catalyzes the only substrate-level phosphorylation in the TCA cycle
YP_001492359.1	COG0074 Succinyl-CoA synthetase, alpha subunit
YP_001492360.1	COG1651 Protein-disulfide isomerase
YP_001492361.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_001492362.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_001492363.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_001492364.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
YP_001492366.1	COG0020 Undecaprenyl pyrophosphate synthase
YP_001492367.1	COG0575 CDP-diglyceride synthetase
YP_001492368.1	COG2919 Septum formation initiator
YP_001492369.1	COG0349 Ribonuclease D
YP_001492370.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_001492371.1	COG0495 Leucyl-tRNA synthetase
YP_001492372.1	binds the polymerase to DNA and acts as a sliding clamp
YP_001492373.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_001492374.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_001492375.1	COG0621 2-methylthioadenine synthetase
YP_001492376.1	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_001492379.1	COG0438 Glycosyltransferase
YP_001492381.1	COG1538 Outer membrane protein
YP_001492382.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_001492385.1	COG0772 Bacterial cell division membrane protein
YP_001492386.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_001492387.1	COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase
YP_001492388.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_001492389.1	COG0739 Membrane proteins related to metalloendopeptidases
YP_001492390.1	COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2
YP_001492391.1	COG0110 Acetyltransferase (isoleucine patch superfamily)
YP_001492392.1	COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1
YP_001492393.1	COG2071 Predicted glutamine amidotransferases
YP_001492394.1	COG2887 RecB family exonuclease
YP_001492396.1	COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF
YP_001492397.1	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)
YP_001492398.1	catalyzes the formation of dUMP from dUTP
YP_001492399.1	COG0616 Periplasmic serine proteases (ClpP class)
YP_001492400.1	COG0526 Thiol-disulfide isomerase and thioredoxins
YP_001492401.1	COG3485 Protocatechuate 3,4-dioxygenase beta subunit
YP_001492404.1	COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2
YP_001492405.1	COG0672 High-affinity Fe2+/Pb2+ permease
YP_001492406.1	Involved in cell division; probably involved in intracellular septation
YP_001492407.1	COG2823 Predicted periplasmic or secreted lipoprotein
YP_001492408.1	COG0797 Lipoproteins
YP_001492409.1	COG1686 D-alanyl-D-alanine carboxypeptidase
YP_001492410.1	COG0477 Permeases of the major facilitator superfamily
YP_001492411.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_001492412.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_001492414.1	COG2255 Holliday junction resolvasome, helicase subunit
YP_001492415.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_001492417.1	COG0632 Holliday junction resolvasome, DNA-binding subunit
YP_001492418.1	COG3177 Uncharacterized conserved protein
YP_001492419.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_001492420.1	involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer
YP_001492422.1	COG0302 GTP cyclohydrolase I
YP_001492423.1	CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS
YP_001492424.1	COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase
YP_001492425.1	COG3202 ATP/ADP translocase
YP_001492426.1	Catalyzes the reversible oxidation of malate to oxaloacetate
YP_001492432.1	COG0039 Malate/lactate dehydrogenases
YP_001492434.1	COG0477 Permeases of the major facilitator superfamily
YP_001492435.1	NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate
YP_001492436.1	COG0679 Predicted permeases
YP_001492437.1	class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine
YP_001492440.1	COG3023 Negative regulator of beta-lactamase expression
YP_001492441.1	COG1396 Predicted transcriptional regulators
YP_001492442.1	Transfers the fatty acyl group on membrane lipoproteins
YP_001492443.1	Catalyzes a key regulatory step in fatty acid biosynthesis
YP_001492446.1	COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH)
YP_001492447.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_001492448.1	COG4765 Uncharacterized protein conserved in bacteria
YP_001492449.1	COG3307 Lipid A core - O-antigen ligase and related enzymes
YP_001492450.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001492451.1	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen
YP_001492452.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001492453.1	COG2827 Predicted endonuclease containing a URI domain
YP_001492454.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001492455.1	COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7
YP_001492456.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001492457.1	COG0759 Uncharacterized conserved protein
YP_001492458.1	responsible for recognizing base lesions in the genome and initiating base excision DNA repair
YP_001492459.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_001492460.1	COG1722 Exonuclease VII small subunit
YP_001492461.1	Essential for efficient processing of 16S rRNA
YP_001492464.1	COG0806 RimM protein, required for 16S rRNA processing
YP_001492465.1	converts protoheme IX and farnesyl diphosphate to heme O
YP_001492466.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_001492467.1	COG0438 Glycosyltransferase
YP_001492469.1	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)
YP_001492470.1	COG0845 Membrane-fusion protein
YP_001492471.1	COG0438 Glycosyltransferase
YP_001492472.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_001492473.1	COG0438 Glycosyltransferase
YP_001492474.1	COG0438 Glycosyltransferase
YP_001492475.1	COG0500 SAM-dependent methyltransferases
YP_001492476.1	COG0381 UDP-N-acetylglucosamine 2-epimerase
YP_001492477.1	COG1086 Predicted nucleoside-diphosphate sugar epimerases
YP_001492479.1	COG1091 dTDP-4-dehydrorhamnose reductase
YP_001492480.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_001492482.1	COG2194 Predicted membrane-associated, metal-dependent hydrolase
YP_001492483.1	COG0330 Membrane protease subunits, stomatin/prohibitin homologs
YP_001492484.1	COG0450 Peroxiredoxin
YP_001492485.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_001492486.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_001492490.1	COG0008 Glutamyl- and glutaminyl-tRNA synthetases
YP_001492491.1	defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly
YP_001492493.1	COG1559 Predicted periplasmic solute-binding protein
YP_001492494.1	catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM
YP_001492500.1	heat shock protein involved in degradation of misfolded proteins
YP_001492501.1	heat shock protein involved in degradation of misfolded proteins
YP_001492504.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_001492514.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_001492516.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_001492521.1	involved in the insertion of copper into subunit I of cytochrome C oxidase
YP_001492522.1	binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters
YP_001492523.1	forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA
YP_001492524.1	flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor
YP_001492529.1	This protein performs the mismatch recognition step during the DNA repair process
YP_001492549.1	subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali
YP_001492550.1	subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone
YP_001492551.1	COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit
YP_001492552.1	subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone
YP_001492553.1	COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit
YP_001492554.1	COG1487 Predicted nucleic acid-binding protein, contains PIN domain
YP_001492555.1	subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone
YP_001492556.1	COG1770 Protease II
YP_001492557.1	COG0772 Bacterial cell division membrane protein
YP_001492558.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_001492559.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_001492560.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_001492561.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_001492562.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_001492563.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_001492564.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_001492565.1	late assembly protein
YP_001492566.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_001492567.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_001492568.1	binds 5S rRNA along with protein L5 and L25
YP_001492569.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_001492570.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_001492571.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif
YP_001492572.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_001492573.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_001492574.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_001492575.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_001492576.1	one of the stabilizing components for the large ribosomal subunit
YP_001492577.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_001492578.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_001492579.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_001492580.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_001492581.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_001492582.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_001492583.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_001492584.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_001492585.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_001492586.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_001492588.1	COG0566 rRNA methylases
YP_001492589.1	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_001492590.1	COG0114 Fumarase
YP_001492591.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_001492592.1	COG0206 Cell division GTPase
YP_001492593.1	COG4574 Serine protease inhibitor ecotin
YP_001492594.1	COG0694 Thioredoxin-like proteins and domains
YP_001492595.1	COG0513 Superfamily II DNA and RNA helicases
YP_001492600.1	COG1278 Cold shock proteins
YP_001492601.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_001492602.1	COG0760 Parvulin-like peptidyl-prolyl isomerase
YP_001492603.1	COG1452 Organic solvent tolerance protein OstA
YP_001492604.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_001492605.1	COG1570 Exonuclease VII, large subunit
YP_001492606.1	COG0708 Exonuclease III
YP_001492607.1	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_001492610.1	COG1373 Predicted ATPase (AAA+ superfamily)
YP_001492611.1	COG0661 Predicted unusual protein kinase
YP_001492612.1	Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone
YP_001492613.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_001492615.1	COG0266 Formamidopyrimidine-DNA glycosylase
YP_001492616.1	COG4553 Poly-beta-hydroxyalkanoate depolymerase
YP_001492617.1	COG0084 Mg-dependent DNase
YP_001492618.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_001492619.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_001492620.1	COG0477 Permeases of the major facilitator superfamily
YP_001492621.1	UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin
YP_001492622.1	COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases
YP_001492623.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_001492624.1	COG0525 Valyl-tRNA synthetase
YP_001492625.1	COG1373 Predicted ATPase (AAA+ superfamily)
YP_001492629.1	COG1322 Uncharacterized protein conserved in bacteria
YP_001492630.1	binds and unfolds substrates as part of the ClpXP protease
YP_001492631.1	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
YP_001492632.1	COG0603 Predicted PP-loop superfamily ATPase
YP_001492634.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_001492637.1	COG0477 Permeases of the major facilitator superfamily
YP_001492638.1	COG4591 ABC-type transport system, involved in lipoprotein release, permease component
YP_001492640.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_001492641.1	COG4536 Putative Mg2+ and Co2+ transporter CorB
YP_001492644.1	COG1138 Cytochrome c biogenesis factor
YP_001492645.1	COG4625 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain
YP_001492646.1	COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases
YP_001492647.1	COG1472 Beta-glucosidase-related glycosidases
YP_001492648.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_001492649.1	transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate
YP_001492650.1	COG0739 Membrane proteins related to metalloendopeptidases
YP_001492652.1	COG2961 Protein involved in catabolism of external DNA
YP_001492653.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_001492654.1	COG4748 Uncharacterized conserved protein
YP_001492655.1	Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)
YP_001492656.1	COG0183 Acetyl-CoA acetyltransferase
YP_001492657.1	COG3202 ATP/ADP translocase
YP_001492658.1	COG1253 Hemolysins and related proteins containing CBS domains
YP_001492659.1	COG0319 Predicted metal-dependent hydrolase
YP_001492660.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_001492661.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_001492662.1	COG0400 Predicted esterase
YP_001492663.1	COG0278 Glutaredoxin-related protein
YP_001492664.1	COG0177 Predicted EndoIII-related endonuclease
YP_001492665.1	COG0313 Predicted methyltransferases
YP_001492667.1	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_001492668.1	COG1267 Phosphatidylglycerophosphatase A and related proteins
YP_001492669.1	COG0261 Ribosomal protein L21
YP_001492670.1	involved in the peptidyltransferase reaction during translation
YP_001492671.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.
YP_001492672.1	COG0527 Aspartokinases
YP_001492674.1	COG0477 Permeases of the major facilitator superfamily
YP_001492675.1	COG1426 Uncharacterized protein conserved in bacteria
YP_001492676.1	COG2902 NAD-specific glutamate dehydrogenase
YP_001492677.1	in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE
YP_001492678.1	COG0486 Predicted GTPase
YP_001492679.1	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_001492680.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_001492681.1	carries the fatty acid chain in fatty acid biosynthesis
YP_001492682.1	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_001492684.1	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
YP_001492685.1	Essential for recycling GMP and indirectly, cGMP
YP_001492686.1	COG1396 Predicted transcriptional regulators
YP_001492687.1	in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall
YP_001492688.1	functions in MreBCD complex in some organisms
YP_001492689.1	COG0795 Predicted permeases
YP_001492690.1	COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins
YP_001492691.1	FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_001492692.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_001492693.1	COG2913 Small protein A (tmRNA-binding)
YP_001492694.1	COG0552 Signal recognition particle GTPase
YP_001492695.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_001492696.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_001492698.1	COG1004 Predicted UDP-glucose 6-dehydrogenase
YP_001492699.1	COG0477 Permeases of the major facilitator superfamily
YP_001492700.1	COG0805 Sec-independent protein secretion pathway component TatC
YP_001492701.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001492703.1	COG3451 Type IV secretory pathway, VirB4 components
YP_001492706.1	COG0861 Membrane protein TerC, possibly involved in tellurium resistance
YP_001492707.1	COG0500 SAM-dependent methyltransferases
YP_001492708.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001492709.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001492710.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_001492711.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001492712.1	ATP-binding protein; required for proper cytochrome c maturation
YP_001492713.1	COG4133 ABC-type transport system involved in cytochrome c biogenesis, ATPase component
YP_001492714.1	COG1373 Predicted ATPase (AAA+ superfamily)
YP_001492715.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001492716.1	COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)
YP_001492717.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001492718.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001492719.1	COG3671 Predicted membrane protein
YP_001492720.1	Catalyzes the conversion of citrate to isocitrate
YP_001492721.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_001492722.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_001492723.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_001492724.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_001492725.1	Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_001492726.1	Catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_001492727.1	COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
YP_001492728.1	COG5009 Membrane carboxypeptidase/penicillin-binding protein
YP_001492729.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_001492732.1	COG0621 2-methylthioadenine synthetase
YP_001492735.1	COG1373 Predicted ATPase (AAA+ superfamily)
YP_001492737.1	COG0475 Kef-type K+ transport systems, membrane components
YP_001492738.1	COG0799 Uncharacterized homolog of plant Iojap protein
YP_001492747.1	COG0271 Stress-induced morphogen (activity unknown)
YP_001492748.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_001492749.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_001492750.1	COG1734 DnaK suppressor protein
YP_001492751.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_001492752.1	COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes
YP_001492753.1	COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases
YP_001492754.1	COG0760 Parvulin-like peptidyl-prolyl isomerase
YP_001492755.1	COG3210 Large exoproteins involved in heme utilization or adhesion
YP_001492758.1	COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins
YP_001492759.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn
YP_001492760.1	COG2003 DNA repair proteins
YP_001492763.1	COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase
YP_001492764.1	COG3637 Opacity protein and related surface antigens
YP_001492765.1	COG3637 Opacity protein and related surface antigens
YP_001492766.1	COG1146 Ferredoxin
YP_001492767.1	COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component
YP_001492768.1	COG0590 Cytosine/adenosine deaminases
YP_001492769.1	COG0053 Predicted Co/Zn/Cd cation transporters
YP_001492770.1	COG4520 Surface antigen
YP_001492771.1	COG1881 Phospholipid-binding protein
YP_001492772.1	COG1121 ABC-type Mn/Zn transport systems, ATPase component
YP_001492773.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_001492774.1	binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA
YP_001492775.1	COG0629 Single-stranded DNA-binding protein
YP_001492776.1	COG0477 Permeases of the major facilitator superfamily
YP_001492777.1	COG1872 Uncharacterized conserved protein
YP_001492778.1	molecular chaperone
YP_001492779.1	catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine
YP_001492780.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_001492781.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_001492782.1	type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH
YP_001492784.1	COG0372 Citrate synthase
YP_001492785.1	COG1573 Uracil-DNA glycosylase
YP_001492786.1	COG0564 Pseudouridylate synthases, 23S RNA-specific
YP_001492787.1	COG2890 Methylase of polypeptide chain release factors
YP_001492788.1	COG0009 Putative translation factor (SUA5)
YP_001492789.1	glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_001492790.1	glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_001492791.1	COG1636 Uncharacterized protein conserved in bacteria
YP_001492793.1	COG0477 Permeases of the major facilitator superfamily
YP_001492795.1	COG1474 Cdc6-related protein, AAA superfamily ATPase
YP_001492796.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001492797.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_001492798.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria
YP_001492799.1	synthesizes RNA primers at the replication forks
YP_001492800.1	COG0170 Dolichol kinase
YP_001492801.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_001492803.1	COG3288 NAD/NADP transhydrogenase alpha subunit
YP_001492804.1	COG2834 Outer membrane lipoprotein-sorting protein
YP_001492805.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; rhe tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_001492806.1	COG0718 Uncharacterized protein conserved in bacteria
YP_001492807.1	COG3577 Predicted aspartyl protease
YP_001492808.1	COG1126 ABC-type polar amino acid transport system, ATPase component
YP_001492809.1	COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
YP_001492810.1	COG0671 Membrane-associated phospholipid phosphatase
YP_001492811.1	COG0795 Predicted permeases
YP_001492812.1	binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_001492813.1	dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.
YP_001492817.1	COG1434 Uncharacterized conserved protein
YP_001492818.1	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein
YP_001492819.1	COG3023 Negative regulator of beta-lactamase expression
YP_001492820.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_001492821.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_001492822.1	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YP_001492823.1	COG4391 Uncharacterized protein conserved in bacteria
YP_001492824.1	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
YP_001492826.1	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
YP_001492827.1	COG0477 Permeases of the major facilitator superfamily
YP_001492828.1	catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis
YP_001492829.1	COG1981 Predicted membrane protein
YP_001492830.1	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_001492831.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III