-- dump date 20140620_033715 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272944000001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 272944000002 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272944000003 catalytic residues [active] 272944000004 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272944000005 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272944000006 Walker A/P-loop; other site 272944000007 ATP binding site [chemical binding]; other site 272944000008 Q-loop/lid; other site 272944000009 ABC transporter signature motif; other site 272944000010 Walker B; other site 272944000011 D-loop; other site 272944000012 H-loop/switch region; other site 272944000013 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272944000014 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 272944000015 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272944000016 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 272944000017 FAD binding pocket [chemical binding]; other site 272944000018 conserved FAD binding motif [chemical binding]; other site 272944000019 phosphate binding motif [ion binding]; other site 272944000020 beta-alpha-beta structure motif; other site 272944000021 NAD binding pocket [chemical binding]; other site 272944000022 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 272944000023 Predicted transcriptional regulator [Transcription]; Region: COG3905 272944000024 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 272944000025 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 272944000026 active site 272944000027 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272944000028 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 272944000029 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 272944000030 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 272944000031 trimer interface [polypeptide binding]; other site 272944000032 active site 272944000033 UDP-GlcNAc binding site [chemical binding]; other site 272944000034 lipid binding site [chemical binding]; lipid-binding site 272944000035 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 272944000036 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272944000037 FMN binding site [chemical binding]; other site 272944000038 active site 272944000039 catalytic residues [active] 272944000040 substrate binding site [chemical binding]; other site 272944000041 Putative catalytic NodB homology domain of uncharacterized protein RC0012 from Rickettsia conorii and its bacterial homologs; Region: CE4_RC0012_like; cd10963 272944000042 NodB motif; other site 272944000043 putative active site [active] 272944000044 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 272944000045 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272944000046 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272944000047 intersubunit interface [polypeptide binding]; other site 272944000048 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 272944000049 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272944000050 active site 272944000051 NTP binding site [chemical binding]; other site 272944000052 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944000053 metal binding triad [ion binding]; metal-binding site 272944000054 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272944000055 Competence protein; Region: Competence; pfam03772 272944000056 Proacrosin binding protein sp32; Region: PBP_sp32; pfam07222 272944000057 Autotransporter beta-domain; Region: Autotransporter; pfam03797 272944000058 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 272944000059 AAA domain; Region: AAA_22; pfam13401 272944000060 Tetratricopeptide repeat; Region: TPR_1; pfam00515 272944000061 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272944000062 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 272944000063 F0F1 ATP synthase subunit B; Validated; Region: PRK06568 272944000064 F0F1 ATP synthase subunit B'; Validated; Region: PRK06569 272944000065 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 272944000066 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 272944000067 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 272944000068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 272944000069 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 272944000070 Thioredoxin; Region: Thioredoxin_4; pfam13462 272944000071 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 272944000072 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272944000073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272944000074 S-adenosylmethionine binding site [chemical binding]; other site 272944000075 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 272944000076 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272944000077 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 272944000078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272944000079 Walker A/P-loop; other site 272944000080 ATP binding site [chemical binding]; other site 272944000081 Q-loop/lid; other site 272944000082 ABC transporter signature motif; other site 272944000083 Walker B; other site 272944000084 D-loop; other site 272944000085 H-loop/switch region; other site 272944000086 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 272944000087 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272944000088 folate binding site [chemical binding]; other site 272944000089 NADP+ binding site [chemical binding]; other site 272944000090 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 272944000091 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 272944000092 dimer interface [polypeptide binding]; other site 272944000093 inhibitor binding site; inhibition site 272944000094 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 272944000095 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 272944000096 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism]; Region: FolK; COG0801 272944000097 catalytic center binding site [active] 272944000098 ATP binding site [chemical binding]; other site 272944000099 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 272944000100 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 272944000101 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism]; Region: FolK; COG0801 272944000102 tetratricopeptide repeat protein; Provisional; Region: PRK11788 272944000103 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 272944000104 Cu(I) binding site [ion binding]; other site 272944000105 Putative transcriptional regulator [Transcription]; Region: COG1678 272944000106 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 272944000107 Protein of unknown function (DUF2748); Region: DUF2748; pfam10871 272944000108 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 272944000109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272944000110 NAD(P) binding site [chemical binding]; other site 272944000111 active site 272944000112 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272944000113 Clp amino terminal domain; Region: Clp_N; pfam02861 272944000114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272944000115 Walker A motif; other site 272944000116 ATP binding site [chemical binding]; other site 272944000117 Walker B motif; other site 272944000118 arginine finger; other site 272944000119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272944000120 Walker A motif; other site 272944000121 ATP binding site [chemical binding]; other site 272944000122 Walker B motif; other site 272944000123 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272944000124 UGMP family protein; Validated; Region: PRK09604 272944000125 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 272944000126 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 272944000127 Di-iron ligands [ion binding]; other site 272944000128 Protein of unknown function (DUF713); Region: DUF713; pfam05218 272944000129 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272944000130 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272944000131 DNA binding site [nucleotide binding] 272944000132 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272944000133 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272944000134 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272944000135 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272944000136 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272944000137 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272944000138 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272944000139 Ligand Binding Site [chemical binding]; other site 272944000140 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944000141 FtsH Extracellular; Region: FtsH_ext; pfam06480 272944000142 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272944000143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272944000144 Walker A motif; other site 272944000145 ATP binding site [chemical binding]; other site 272944000146 Walker B motif; other site 272944000147 arginine finger; other site 272944000148 Peptidase family M41; Region: Peptidase_M41; pfam01434 272944000149 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 272944000150 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272944000151 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272944000152 catalytic loop [active] 272944000153 iron binding site [ion binding]; other site 272944000154 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 272944000155 Uncharacterized conserved protein [Function unknown]; Region: COG1565 272944000156 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 272944000157 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944000158 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 272944000159 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272944000160 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272944000161 membrane protein insertase; Provisional; Region: PRK01318 272944000162 YidC periplasmic domain; Region: YidC_periplas; pfam14849 272944000163 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 272944000164 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272944000165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272944000166 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 272944000167 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272944000168 active site 272944000169 catalytic residues [active] 272944000170 metal binding site [ion binding]; metal-binding site 272944000171 TLC ATP/ADP transporter; Region: TLC; pfam03219 272944000172 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 272944000173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272944000174 putative substrate translocation pore; other site 272944000175 Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; Region: NDK; smart00562 272944000176 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 272944000177 active site 272944000178 multimer interface [polypeptide binding]; other site 272944000179 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272944000180 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 272944000181 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 272944000182 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272944000183 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 272944000184 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272944000185 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272944000186 P-loop; other site 272944000187 Magnesium ion binding site [ion binding]; other site 272944000188 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272944000189 ParB-like nuclease domain; Region: ParB; smart00470 272944000190 KorB domain; Region: KorB; pfam08535 272944000191 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 272944000192 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272944000193 ABC transporter; Region: ABC_tran_2; pfam12848 272944000194 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272944000195 Protein of unknown function (DUF2672); Region: DUF2672; pfam10878 272944000196 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 272944000197 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 272944000198 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 272944000199 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272944000200 Zn2+ binding site [ion binding]; other site 272944000201 Mg2+ binding site [ion binding]; other site 272944000202 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 272944000203 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 272944000204 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 272944000205 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272944000206 active site 272944000207 HIGH motif; other site 272944000208 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272944000209 KMSK motif region; other site 272944000210 tRNA binding surface [nucleotide binding]; other site 272944000211 DALR anticodon binding domain; Region: DALR_1; smart00836 272944000212 anticodon binding site; other site 272944000213 Sporulation related domain; Region: SPOR; pfam05036 272944000214 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 272944000215 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272944000216 CAP-like domain; other site 272944000217 active site 272944000218 primary dimer interface [polypeptide binding]; other site 272944000219 Gram-negative porin; Region: Porin_4; pfam13609 272944000220 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272944000221 trimer interface [polypeptide binding]; other site 272944000222 active site 272944000223 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 272944000224 SecA binding site; other site 272944000225 Preprotein binding site; other site 272944000226 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272944000227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272944000228 active site 272944000229 phosphorylation site [posttranslational modification] 272944000230 intermolecular recognition site; other site 272944000231 dimerization interface [polypeptide binding]; other site 272944000232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272944000233 DNA binding site [nucleotide binding] 272944000234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 272944000235 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 272944000236 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 272944000237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 272944000238 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 272944000239 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 272944000240 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272944000241 EamA-like transporter family; Region: EamA; pfam00892 272944000242 EamA-like transporter family; Region: EamA; pfam00892 272944000243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272944000244 metabolite-proton symporter; Region: 2A0106; TIGR00883 272944000245 putative substrate translocation pore; other site 272944000246 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 272944000247 Autotransporter beta-domain; Region: Autotransporter; pfam03797 272944000248 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272944000249 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272944000250 active site 272944000251 HIGH motif; other site 272944000252 KMSKS motif; other site 272944000253 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272944000254 tRNA binding surface [nucleotide binding]; other site 272944000255 anticodon binding site; other site 272944000256 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272944000257 rRNA interaction site [nucleotide binding]; other site 272944000258 S8 interaction site; other site 272944000259 putative laminin-1 binding site; other site 272944000260 elongation factor Ts; Provisional; Region: tsf; PRK09377 272944000261 UBA/TS-N domain; Region: UBA; pfam00627 272944000262 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 272944000263 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944000264 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 272944000265 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272944000266 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 272944000267 putative acyl-acceptor binding pocket; other site 272944000268 aspartate aminotransferase; Provisional; Region: PRK05764 272944000269 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272944000270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272944000271 homodimer interface [polypeptide binding]; other site 272944000272 catalytic residue [active] 272944000273 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 272944000274 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272944000275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272944000276 binding surface 272944000277 TPR motif; other site 272944000278 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272944000279 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272944000280 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 272944000281 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854 272944000282 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 272944000283 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272944000284 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272944000285 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 272944000286 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272944000287 active site 272944000288 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944000289 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 272944000290 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272944000291 active site 272944000292 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272944000293 dimer interface [polypeptide binding]; other site 272944000294 substrate binding site [chemical binding]; other site 272944000295 catalytic residues [active] 272944000296 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 272944000297 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 272944000298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272944000299 Walker A/P-loop; other site 272944000300 ATP binding site [chemical binding]; other site 272944000301 Q-loop/lid; other site 272944000302 ABC transporter signature motif; other site 272944000303 Walker B; other site 272944000304 D-loop; other site 272944000305 H-loop/switch region; other site 272944000306 CheD chemotactic sensory transduction; Region: CheD; cl00810 272944000307 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272944000308 50S ribosomal protein L31; Provisional; Region: PRK01397 272944000309 Predicted GTPase [General function prediction only]; Region: COG0218 272944000310 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272944000311 G1 box; other site 272944000312 GTP/Mg2+ binding site [chemical binding]; other site 272944000313 Switch I region; other site 272944000314 G2 box; other site 272944000315 G3 box; other site 272944000316 Switch II region; other site 272944000317 G4 box; other site 272944000318 G5 box; other site 272944000319 Acetylglutamate kinase [Amino acid transport and metabolism]; Region: ArgB; COG0548 272944000320 nucleotide binding site [chemical binding]; other site 272944000321 substrate binding site [chemical binding]; other site 272944000322 type IV secretion system protein VirB3; Provisional; Region: PRK13899 272944000323 type IV secretion system ATPase VirB4; Provisional; Region: PRK13898 272944000324 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 272944000325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272944000326 Walker A/P-loop; other site 272944000327 ATP binding site [chemical binding]; other site 272944000328 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 272944000329 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 272944000330 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 272944000331 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 272944000332 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 272944000333 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 272944000334 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 272944000335 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 272944000336 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 272944000337 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 272944000338 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 272944000339 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272944000340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750 272944000341 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 272944000342 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 272944000343 Protein export membrane protein; Region: SecD_SecF; pfam02355 272944000344 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 272944000345 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 272944000346 SLBB domain; Region: SLBB; pfam10531 272944000347 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 272944000348 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272944000349 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272944000350 Catalytic site [active] 272944000351 ribonuclease III; Reviewed; Region: rnc; PRK00102 272944000352 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272944000353 dimerization interface [polypeptide binding]; other site 272944000354 active site 272944000355 metal binding site [ion binding]; metal-binding site 272944000356 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272944000357 dsRNA binding site [nucleotide binding]; other site 272944000358 GTPase Era; Provisional; Region: era; PRK15494 272944000359 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944000360 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272944000361 G1 box; other site 272944000362 GTP/Mg2+ binding site [chemical binding]; other site 272944000363 Switch I region; other site 272944000364 G2 box; other site 272944000365 Switch II region; other site 272944000366 G3 box; other site 272944000367 G4 box; other site 272944000368 G5 box; other site 272944000369 KH domain; Region: KH_2; pfam07650 272944000370 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 272944000371 active site 272944000372 putative DNA-binding cleft [nucleotide binding]; other site 272944000373 dimer interface [polypeptide binding]; other site 272944000374 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 272944000375 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 272944000376 nucleotidyltransferase substrate binding protein, HI0074 family; Region: HI0074; TIGR01987 272944000377 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 272944000378 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 272944000379 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 272944000380 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 272944000381 Walker A motif; other site 272944000382 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 272944000383 HflK protein; Region: hflK; TIGR01933 272944000384 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272944000385 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 272944000386 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 272944000387 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272944000388 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272944000389 protein binding site [polypeptide binding]; other site 272944000390 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272944000391 protein binding site [polypeptide binding]; other site 272944000392 hypothetical protein; Validated; Region: PRK01415 272944000393 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 272944000394 active site residue [active] 272944000395 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 272944000396 Iron-sulfur protein interface; other site 272944000397 proximal quinone binding site [chemical binding]; other site 272944000398 SdhD (CybS) interface [polypeptide binding]; other site 272944000399 proximal heme binding site [chemical binding]; other site 272944000400 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 272944000401 putative SdhC subunit interface [polypeptide binding]; other site 272944000402 putative proximal heme binding site [chemical binding]; other site 272944000403 putative Iron-sulfur protein interface [polypeptide binding]; other site 272944000404 putative proximal quinone binding site; other site 272944000405 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 272944000406 L-aspartate oxidase; Provisional; Region: PRK06175 272944000407 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272944000408 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272944000409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272944000410 dimer interface [polypeptide binding]; other site 272944000411 conserved gate region; other site 272944000412 putative PBP binding loops; other site 272944000413 ABC-ATPase subunit interface; other site 272944000414 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272944000415 S17 interaction site [polypeptide binding]; other site 272944000416 S8 interaction site; other site 272944000417 16S rRNA interaction site [nucleotide binding]; other site 272944000418 streptomycin interaction site [chemical binding]; other site 272944000419 23S rRNA interaction site [nucleotide binding]; other site 272944000420 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272944000421 30S ribosomal protein S7; Validated; Region: PRK05302 272944000422 elongation factor G; Reviewed; Region: PRK00007 272944000423 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272944000424 G1 box; other site 272944000425 putative GEF interaction site [polypeptide binding]; other site 272944000426 GTP/Mg2+ binding site [chemical binding]; other site 272944000427 Switch I region; other site 272944000428 G2 box; other site 272944000429 G3 box; other site 272944000430 Switch II region; other site 272944000431 G4 box; other site 272944000432 G5 box; other site 272944000433 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272944000434 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272944000435 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272944000436 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272944000437 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 272944000438 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272944000439 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272944000440 putative homodimer interface [polypeptide binding]; other site 272944000441 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272944000442 heterodimer interface [polypeptide binding]; other site 272944000443 homodimer interface [polypeptide binding]; other site 272944000444 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272944000445 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272944000446 putative thiostrepton binding site; other site 272944000447 23S rRNA interface [nucleotide binding]; other site 272944000448 L7/L12 interface [polypeptide binding]; other site 272944000449 L25 interface [polypeptide binding]; other site 272944000450 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272944000451 mRNA/rRNA interface [nucleotide binding]; other site 272944000452 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272944000453 23S rRNA interface [nucleotide binding]; other site 272944000454 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272944000455 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272944000456 core dimer interface [polypeptide binding]; other site 272944000457 peripheral dimer interface [polypeptide binding]; other site 272944000458 L10 interface [polypeptide binding]; other site 272944000459 L11 interface [polypeptide binding]; other site 272944000460 putative EF-Tu interaction site [polypeptide binding]; other site 272944000461 putative EF-G interaction site [polypeptide binding]; other site 272944000462 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272944000463 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272944000464 RPB12 interaction site [polypeptide binding]; other site 272944000465 RPB1 interaction site [polypeptide binding]; other site 272944000466 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 272944000467 RPB10 interaction site [polypeptide binding]; other site 272944000468 RPB11 interaction site [polypeptide binding]; other site 272944000469 RPB3 interaction site [polypeptide binding]; other site 272944000470 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 272944000471 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 272944000472 beta and beta' interface [polypeptide binding]; other site 272944000473 beta' and sigma factor interface [polypeptide binding]; other site 272944000474 Zn-binding [ion binding]; other site 272944000475 active site region [active] 272944000476 catalytic site [active] 272944000477 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272944000478 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 272944000479 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272944000480 G-loop; other site 272944000481 DNA binding site [nucleotide binding] 272944000482 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944000483 multifunctional aminopeptidase A; Provisional; Region: PRK00913 272944000484 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272944000485 interface (dimer of trimers) [polypeptide binding]; other site 272944000486 Substrate-binding/catalytic site; other site 272944000487 Zn-binding sites [ion binding]; other site 272944000488 ATPase MipZ; Region: MipZ; pfam09140 272944000489 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272944000490 P-loop; other site 272944000491 Magnesium ion binding site [ion binding]; other site 272944000492 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 272944000493 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272944000494 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272944000495 dimer interface [polypeptide binding]; other site 272944000496 anticodon binding site; other site 272944000497 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272944000498 homodimer interface [polypeptide binding]; other site 272944000499 motif 1; other site 272944000500 active site 272944000501 motif 2; other site 272944000502 GAD domain; Region: GAD; pfam02938 272944000503 motif 3; other site 272944000504 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 272944000505 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 272944000506 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272944000507 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272944000508 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272944000509 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272944000510 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272944000511 substrate binding pocket [chemical binding]; other site 272944000512 membrane-bound complex binding site; other site 272944000513 hinge residues; other site 272944000514 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272944000515 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272944000516 GatB domain; Region: GatB_Yqey; smart00845 272944000517 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272944000518 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 272944000519 Uncharacterized conserved protein [Function unknown]; Region: COG4997 272944000520 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272944000521 hinge region; other site 272944000522 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272944000523 putative nucleotide binding site [chemical binding]; other site 272944000524 uridine monophosphate binding site [chemical binding]; other site 272944000525 homohexameric interface [polypeptide binding]; other site 272944000526 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK06580 272944000527 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272944000528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272944000529 putative substrate translocation pore; other site 272944000530 Protein of unknown function (DUF2674); Region: DUF2674; pfam10879 272944000531 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 272944000532 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272944000533 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272944000534 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272944000535 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272944000536 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272944000537 Surface antigen; Region: Bac_surface_Ag; pfam01103 272944000538 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 272944000539 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272944000540 active site 272944000541 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272944000542 protein binding site [polypeptide binding]; other site 272944000543 putative substrate binding region [chemical binding]; other site 272944000544 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 272944000545 putative RNA binding site [nucleotide binding]; other site 272944000546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272944000547 S-adenosylmethionine binding site [chemical binding]; other site 272944000548 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 272944000549 putative coenzyme Q binding site [chemical binding]; other site 272944000550 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944000551 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 272944000552 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 272944000553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 272944000554 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272944000555 MMPL family; Region: MMPL; cl14618 272944000556 MMPL family; Region: MMPL; cl14618 272944000557 histone-like DNA-binding protein HU; Region: HU; cd13831 272944000558 dimer interface [polypeptide binding]; other site 272944000559 DNA binding site [nucleotide binding] 272944000560 DNA polymerase III subunit delta'; Validated; Region: PRK06581 272944000561 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272944000562 signal recognition particle protein; Provisional; Region: PRK10867 272944000563 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272944000564 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272944000565 P loop; other site 272944000566 GTP binding site [chemical binding]; other site 272944000567 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272944000568 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 272944000569 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272944000570 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 272944000571 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 272944000572 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 272944000573 coproporphyrinogen III oxidase; Provisional; Region: PRK06582 272944000574 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272944000575 FeS/SAM binding site; other site 272944000576 HemN C-terminal domain; Region: HemN_C; pfam06969 272944000577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272944000578 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272944000579 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 272944000580 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 272944000581 active site 272944000582 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 272944000583 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272944000584 E3 interaction surface; other site 272944000585 lipoyl attachment site [posttranslational modification]; other site 272944000586 e3 binding domain; Region: E3_binding; pfam02817 272944000587 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272944000588 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 272944000589 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 272944000590 TPP-binding site [chemical binding]; other site 272944000591 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 272944000592 dimer interface [polypeptide binding]; other site 272944000593 PYR/PP interface [polypeptide binding]; other site 272944000594 TPP binding site [chemical binding]; other site 272944000595 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 272944000596 active site 272944000597 Zn binding site [ion binding]; other site 272944000598 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 272944000599 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272944000600 Walker A/P-loop; other site 272944000601 ATP binding site [chemical binding]; other site 272944000602 Q-loop/lid; other site 272944000603 Allexivirus 40kDa protein; Region: Allexi_40kDa; pfam05549 272944000604 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272944000605 ABC transporter signature motif; other site 272944000606 Walker B; other site 272944000607 D-loop; other site 272944000608 H-loop/switch region; other site 272944000609 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 272944000610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272944000611 binding surface 272944000612 TPR motif; other site 272944000613 Tetratricopeptide repeat; Region: TPR_6; pfam13174 272944000614 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 272944000615 chaperone protein DnaJ; Provisional; Region: PRK14300 272944000616 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272944000617 HSP70 interaction site [polypeptide binding]; other site 272944000618 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272944000619 substrate binding site [polypeptide binding]; other site 272944000620 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272944000621 Zn binding sites [ion binding]; other site 272944000622 dimer interface [polypeptide binding]; other site 272944000623 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272944000624 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272944000625 nucleotide binding site [chemical binding]; other site 272944000626 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272944000627 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272944000628 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272944000629 Lipopolysaccharide-assembly; Region: LptE; cl01125 272944000630 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 272944000631 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 272944000632 diiron binding motif [ion binding]; other site 272944000633 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 272944000634 Subunit III/VIIa interface [polypeptide binding]; other site 272944000635 Phospholipid binding site [chemical binding]; other site 272944000636 Subunit I/III interface [polypeptide binding]; other site 272944000637 Subunit III/VIb interface [polypeptide binding]; other site 272944000638 Subunit III/VIa interface; other site 272944000639 Subunit III/Vb interface [polypeptide binding]; other site 272944000640 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 272944000641 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 272944000642 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 272944000643 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 272944000644 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 272944000645 trimer interface [polypeptide binding]; other site 272944000646 active site 272944000647 substrate binding site [chemical binding]; other site 272944000648 CoA binding site [chemical binding]; other site 272944000649 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 272944000650 Transglycosylase; Region: Transgly; pfam00912 272944000651 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272944000652 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 272944000653 Autotransporter beta-domain; Region: Autotransporter; smart00869 272944000654 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272944000655 Ligand Binding Site [chemical binding]; other site 272944000656 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 272944000657 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272944000658 catalytic loop [active] 272944000659 iron binding site [ion binding]; other site 272944000660 chaperone protein HscA; Provisional; Region: hscA; PRK01433 272944000661 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272944000662 nucleotide binding site [chemical binding]; other site 272944000663 co-chaperone HscB; Provisional; Region: hscB; PRK01356 272944000664 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272944000665 HSP70 interaction site [polypeptide binding]; other site 272944000666 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272944000667 RNA/DNA hybrid binding site [nucleotide binding]; other site 272944000668 active site 272944000669 excinuclease ABC subunit B; Provisional; Region: PRK05298 272944000670 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272944000671 ATP binding site [chemical binding]; other site 272944000672 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 272944000673 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272944000674 nucleotide binding region [chemical binding]; other site 272944000675 ATP-binding site [chemical binding]; other site 272944000676 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272944000677 UvrB/uvrC motif; Region: UVR; pfam02151 272944000678 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 272944000679 GSH binding site [chemical binding]; other site 272944000680 catalytic residues [active] 272944000681 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 272944000682 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 272944000683 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 272944000684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272944000685 Walker A/P-loop; other site 272944000686 ATP binding site [chemical binding]; other site 272944000687 Q-loop/lid; other site 272944000688 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 272944000689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272944000690 H-loop/switch region; other site 272944000691 DNA gyrase subunit A; Validated; Region: PRK05560 272944000692 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272944000693 CAP-like domain; other site 272944000694 active site 272944000695 primary dimer interface [polypeptide binding]; other site 272944000696 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272944000697 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272944000698 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272944000699 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272944000700 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272944000701 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272944000702 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 272944000703 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272944000704 active site 272944000705 catalytic residues [active] 272944000706 metal binding site [ion binding]; metal-binding site 272944000707 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272944000708 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272944000709 putative active site [active] 272944000710 substrate binding site [chemical binding]; other site 272944000711 putative cosubstrate binding site; other site 272944000712 catalytic site [active] 272944000713 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272944000714 substrate binding site [chemical binding]; other site 272944000715 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism]; Region: COG4421 272944000716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272944000717 Walker A motif; other site 272944000718 ATP binding site [chemical binding]; other site 272944000719 Walker B motif; other site 272944000720 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: PRK01424 272944000721 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 272944000722 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272944000723 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272944000724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272944000725 Walker A/P-loop; other site 272944000726 ATP binding site [chemical binding]; other site 272944000727 Q-loop/lid; other site 272944000728 ABC transporter signature motif; other site 272944000729 Walker B; other site 272944000730 D-loop; other site 272944000731 H-loop/switch region; other site 272944000732 Protein of unknown function (DUF2671); Region: DUF2671; pfam10877 272944000733 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272944000734 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 272944000735 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272944000736 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 272944000737 toxin-antitoxin system, toxin component, Txe/YoeB family; Region: toxin_Txe_YoeB; TIGR02116 272944000738 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272944000739 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 272944000740 putative metal binding site; other site 272944000741 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272944000742 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272944000743 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272944000744 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 272944000745 ATP binding site [chemical binding]; other site 272944000746 active site 272944000747 substrate binding site [chemical binding]; other site 272944000748 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272944000749 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 272944000750 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272944000751 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272944000752 active site 272944000753 dimer interface [polypeptide binding]; other site 272944000754 motif 1; other site 272944000755 motif 2; other site 272944000756 motif 3; other site 272944000757 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272944000758 anticodon binding site; other site 272944000759 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272944000760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272944000761 ABC transporter signature motif; other site 272944000762 Walker B; other site 272944000763 D-loop; other site 272944000764 H-loop/switch region; other site 272944000765 Zn-ribbon-containing, possibly nucleic-acid-binding protein [General function prediction only]; Region: COG5595 272944000766 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; cl02380 272944000767 Protein of unknown function (DUF2660); Region: DUF2660; pfam10859 272944000768 V-type ATP synthase subunit I; Validated; Region: PRK05771 272944000769 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 272944000770 Outer membrane efflux protein; Region: OEP; pfam02321 272944000771 Outer membrane efflux protein; Region: OEP; pfam02321 272944000772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 272944000773 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 272944000774 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272944000775 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272944000776 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 272944000777 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 272944000778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272944000779 ATP binding site [chemical binding]; other site 272944000780 Mg2+ binding site [ion binding]; other site 272944000781 G-X-G motif; other site 272944000782 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272944000783 anchoring element; other site 272944000784 dimer interface [polypeptide binding]; other site 272944000785 ATP binding site [chemical binding]; other site 272944000786 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272944000787 active site 272944000788 metal binding site [ion binding]; metal-binding site 272944000789 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272944000790 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 272944000791 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 272944000792 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272944000793 protein binding site [polypeptide binding]; other site 272944000794 Catalytic dyad [active] 272944000795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272944000796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272944000797 dimer interface [polypeptide binding]; other site 272944000798 phosphorylation site [posttranslational modification] 272944000799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272944000800 ATP binding site [chemical binding]; other site 272944000801 Mg2+ binding site [ion binding]; other site 272944000802 G-X-G motif; other site 272944000803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 272944000804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272944000805 binding surface 272944000806 TPR motif; other site 272944000807 Protein of unknown function (DUF2659); Region: DUF2659; pfam10858 272944000808 FOG: WD40-like repeat [Function unknown]; Region: COG1520 272944000809 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 272944000810 Trp docking motif [polypeptide binding]; other site 272944000811 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272944000812 23S rRNA interface [nucleotide binding]; other site 272944000813 L3 interface [polypeptide binding]; other site 272944000814 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272944000815 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 272944000816 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 272944000817 putative active site [active] 272944000818 Ap4A binding site [chemical binding]; other site 272944000819 nudix motif; other site 272944000820 putative metal binding site [ion binding]; other site 272944000821 response regulator PleD; Reviewed; Region: pleD; PRK09581 272944000822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272944000823 active site 272944000824 phosphorylation site [posttranslational modification] 272944000825 intermolecular recognition site; other site 272944000826 dimerization interface [polypeptide binding]; other site 272944000827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 272944000828 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272944000829 metal binding site [ion binding]; metal-binding site 272944000830 active site 272944000831 I-site; other site 272944000832 elongation factor P; Validated; Region: PRK00529 272944000833 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272944000834 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272944000835 RNA binding site [nucleotide binding]; other site 272944000836 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272944000837 RNA binding site [nucleotide binding]; other site 272944000838 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 272944000839 active site 272944000840 Domain of unknown function (DUF2610); Region: DUF2610; pfam11020 272944000841 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 272944000842 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 272944000843 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272944000844 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 272944000845 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 272944000846 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272944000847 HlyD family secretion protein; Region: HlyD_3; pfam13437 272944000848 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 272944000849 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272944000850 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272944000851 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272944000852 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272944000853 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272944000854 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 272944000855 FAD binding domain; Region: FAD_binding_4; pfam01565 272944000856 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272944000857 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 272944000858 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272944000859 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272944000860 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 272944000861 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272944000862 Cell division protein FtsQ; Region: FtsQ; pfam03799 272944000863 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 272944000864 Cell division protein FtsA; Region: FtsA; smart00842 272944000865 Cell division protein FtsA; Region: FtsA; pfam14450 272944000866 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 272944000867 Cytochrome c2 [Energy production and conversion]; Region: COG3474 272944000868 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 272944000869 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 272944000870 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 272944000871 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 272944000872 homodimer interface [polypeptide binding]; other site 272944000873 oligonucleotide binding site [chemical binding]; other site 272944000874 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 272944000875 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 272944000876 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272944000877 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272944000878 RNA binding surface [nucleotide binding]; other site 272944000879 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272944000880 active site 272944000881 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272944000882 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 272944000883 putative catalytic site [active] 272944000884 putative phosphate binding site [ion binding]; other site 272944000885 active site 272944000886 metal binding site A [ion binding]; metal-binding site 272944000887 DNA binding site [nucleotide binding] 272944000888 putative AP binding site [nucleotide binding]; other site 272944000889 putative metal binding site B [ion binding]; other site 272944000890 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272944000891 tetramer interface [polypeptide binding]; other site 272944000892 TPP-binding site [chemical binding]; other site 272944000893 heterodimer interface [polypeptide binding]; other site 272944000894 phosphorylation loop region [posttranslational modification] 272944000895 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 272944000896 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272944000897 alpha subunit interface [polypeptide binding]; other site 272944000898 TPP binding site [chemical binding]; other site 272944000899 heterodimer interface [polypeptide binding]; other site 272944000900 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272944000901 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 272944000902 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272944000903 G1 box; other site 272944000904 putative GEF interaction site [polypeptide binding]; other site 272944000905 GTP/Mg2+ binding site [chemical binding]; other site 272944000906 Switch I region; other site 272944000907 G2 box; other site 272944000908 G3 box; other site 272944000909 Switch II region; other site 272944000910 G4 box; other site 272944000911 G5 box; other site 272944000912 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272944000913 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272944000914 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 272944000915 isocitrate dehydrogenase; Validated; Region: PRK09222 272944000916 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 272944000917 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 272944000918 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12507 272944000919 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 272944000920 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 272944000921 CcmB protein; Region: CcmB; cl17444 272944000922 Protein of unknown function (DUF2670); Region: DUF2670; pfam10875 272944000923 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 272944000924 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 272944000925 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 272944000926 [2Fe-2S] cluster binding site [ion binding]; other site 272944000927 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 272944000928 Qi binding site; other site 272944000929 cytochrome b; Provisional; Region: CYTB; MTH00191 272944000930 intrachain domain interface; other site 272944000931 interchain domain interface [polypeptide binding]; other site 272944000932 heme bH binding site [chemical binding]; other site 272944000933 heme bL binding site [chemical binding]; other site 272944000934 Qo binding site; other site 272944000935 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 272944000936 interchain domain interface [polypeptide binding]; other site 272944000937 intrachain domain interface; other site 272944000938 Qi binding site; other site 272944000939 Qo binding site; other site 272944000940 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 272944000941 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 272944000942 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272944000943 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272944000944 putative dimer interface [polypeptide binding]; other site 272944000945 Protein of unknown function (DUF1016); Region: DUF1016; cl19557 272944000946 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 272944000947 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 272944000948 peptide chain release factor 2; Validated; Region: prfB; PRK00578 272944000949 PCRF domain; Region: PCRF; pfam03462 272944000950 RF-1 domain; Region: RF-1; pfam00472 272944000951 GTP-binding protein LepA; Provisional; Region: PRK05433 272944000952 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272944000953 G1 box; other site 272944000954 putative GEF interaction site [polypeptide binding]; other site 272944000955 GTP/Mg2+ binding site [chemical binding]; other site 272944000956 Switch I region; other site 272944000957 G2 box; other site 272944000958 G3 box; other site 272944000959 Switch II region; other site 272944000960 G4 box; other site 272944000961 G5 box; other site 272944000962 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272944000963 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272944000964 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272944000965 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272944000966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 272944000967 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272944000968 HD domain; Region: HD_4; pfam13328 272944000969 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 272944000970 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 272944000971 Rickettsial palindromic element RPE3 domain; Region: RPE3; TIGR03775 272944000972 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272944000973 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06588 272944000974 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272944000975 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272944000976 oligomeric interface; other site 272944000977 putative active site [active] 272944000978 homodimer interface [polypeptide binding]; other site 272944000979 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06589 272944000980 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272944000981 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06591 272944000982 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272944000983 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 272944000984 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 272944000985 VirB7 interaction site; other site 272944000986 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 272944000987 Protein of unknown function (DUF2706); Region: DUF2706; pfam10913 272944000988 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 272944000989 Type IV secretory pathway, VirB9 components [Intracellular trafficking and secretion]; Region: VirB9; COG3504 272944000990 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 272944000991 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 272944000992 type IV secretion system ATPase VirB11; Provisional; Region: PRK13900 272944000993 Walker A motif; other site 272944000994 ATP binding site [chemical binding]; other site 272944000995 Walker B motif; other site 272944000996 type IV secretion system component VirD4; Provisional; Region: PRK13897 272944000997 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 272944000998 Walker A motif; other site 272944000999 ATP binding site [chemical binding]; other site 272944001000 Walker B motif; other site 272944001001 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 272944001002 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 272944001003 Phage portal protein; Region: Phage_portal; cl19194 272944001004 Phage portal protein; Region: Phage_portal; cl19194 272944001005 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 272944001006 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 272944001007 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 272944001008 active site 272944001009 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272944001010 MutS domain I; Region: MutS_I; pfam01624 272944001011 MutS domain II; Region: MutS_II; pfam05188 272944001012 MutS domain III; Region: MutS_III; pfam05192 272944001013 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 272944001014 Walker A/P-loop; other site 272944001015 ATP binding site [chemical binding]; other site 272944001016 Q-loop/lid; other site 272944001017 ABC transporter signature motif; other site 272944001018 Walker B; other site 272944001019 D-loop; other site 272944001020 H-loop/switch region; other site 272944001021 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 272944001022 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272944001023 Peptidase family M23; Region: Peptidase_M23; pfam01551 272944001024 Protein of unknown function DUF45; Region: DUF45; pfam01863 272944001025 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 272944001026 translocation protein TolB; Provisional; Region: tolB; PRK05137 272944001027 TolB amino-terminal domain; Region: TolB_N; pfam04052 272944001028 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272944001029 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272944001030 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272944001031 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 272944001032 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272944001033 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272944001034 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 272944001035 DNA binding residues [nucleotide binding] 272944001036 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 272944001037 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 272944001038 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272944001039 Ligand Binding Site [chemical binding]; other site 272944001040 amino acid transporter; Region: 2A0306; TIGR00909 272944001041 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272944001042 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 272944001043 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272944001044 dimer interface [polypeptide binding]; other site 272944001045 motif 1; other site 272944001046 active site 272944001047 motif 2; other site 272944001048 motif 3; other site 272944001049 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272944001050 anticodon binding site; other site 272944001051 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272944001052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272944001053 Walker A/P-loop; other site 272944001054 ATP binding site [chemical binding]; other site 272944001055 Q-loop/lid; other site 272944001056 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272944001057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272944001058 Walker B; other site 272944001059 D-loop; other site 272944001060 H-loop/switch region; other site 272944001061 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 272944001062 TolQ protein; Region: tolQ; TIGR02796 272944001063 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 272944001064 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272944001065 HD domain; Region: HD_4; pfam13328 272944001066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272944001067 metabolite-proton symporter; Region: 2A0106; TIGR00883 272944001068 putative substrate translocation pore; other site 272944001069 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272944001070 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 272944001071 HlyD family secretion protein; Region: HlyD_3; pfam13437 272944001072 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 272944001073 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272944001074 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 272944001075 Walker A/P-loop; other site 272944001076 ATP binding site [chemical binding]; other site 272944001077 Q-loop/lid; other site 272944001078 ABC transporter signature motif; other site 272944001079 Walker B; other site 272944001080 D-loop; other site 272944001081 H-loop/switch region; other site 272944001082 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 272944001083 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 272944001084 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 272944001085 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272944001086 nucleotide binding site/active site [active] 272944001087 HIT family signature motif; other site 272944001088 catalytic residue [active] 272944001089 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 272944001090 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 272944001091 active site 272944001092 HslU subunit interaction site [polypeptide binding]; other site 272944001093 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 272944001094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272944001095 Walker A motif; other site 272944001096 ATP binding site [chemical binding]; other site 272944001097 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 272944001098 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272944001099 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 272944001100 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272944001101 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 272944001102 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 272944001103 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 272944001104 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 272944001105 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 272944001106 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 272944001107 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 272944001108 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272944001109 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 272944001110 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 272944001111 Rickettsial palindromic element RPE3 domain; Region: RPE3; TIGR03775 272944001112 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 272944001113 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 272944001114 dimerization interface [polypeptide binding]; other site 272944001115 frataxin-like protein; Provisional; Region: cyaY; PRK01379 272944001116 putative iron binding site [ion binding]; other site 272944001117 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 272944001118 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 272944001119 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 272944001120 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 272944001121 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272944001122 active site 272944001123 HIGH motif; other site 272944001124 KMSKS motif; other site 272944001125 DNA topoisomerase I; Validated; Region: PRK06599 272944001126 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272944001127 active site 272944001128 interdomain interaction site; other site 272944001129 putative metal-binding site [ion binding]; other site 272944001130 nucleotide binding site [chemical binding]; other site 272944001131 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272944001132 domain I; other site 272944001133 DNA binding groove [nucleotide binding] 272944001134 phosphate binding site [ion binding]; other site 272944001135 domain II; other site 272944001136 domain III; other site 272944001137 nucleotide binding site [chemical binding]; other site 272944001138 catalytic site [active] 272944001139 domain IV; other site 272944001140 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272944001141 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272944001142 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 272944001143 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 272944001144 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272944001145 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272944001146 dimer interface [polypeptide binding]; other site 272944001147 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272944001148 catalytic triad [active] 272944001149 peroxidatic and resolving cysteines [active] 272944001150 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272944001151 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 272944001152 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 272944001153 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 272944001154 Sulfatase; Region: Sulfatase; pfam00884 272944001155 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 272944001156 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 272944001157 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272944001158 NADP binding site [chemical binding]; other site 272944001159 active site 272944001160 putative substrate binding site [chemical binding]; other site 272944001161 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 272944001162 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 272944001163 NAD(P) binding site [chemical binding]; other site 272944001164 homodimer interface [polypeptide binding]; other site 272944001165 substrate binding site [chemical binding]; other site 272944001166 active site 272944001167 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 272944001168 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 272944001169 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 272944001170 active site 272944001171 homodimer interface [polypeptide binding]; other site 272944001172 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl19139 272944001173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272944001174 S-adenosylmethionine binding site [chemical binding]; other site 272944001175 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272944001176 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272944001177 active site 272944001178 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272944001179 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272944001180 active site 272944001181 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 272944001182 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 272944001183 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 272944001184 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272944001185 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272944001186 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 272944001187 catalytic site [active] 272944001188 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272944001189 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 272944001190 putative ADP-binding pocket [chemical binding]; other site 272944001191 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272944001192 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272944001193 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272944001194 RNA binding surface [nucleotide binding]; other site 272944001195 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 272944001196 putative active site [active] 272944001197 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 272944001198 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 272944001199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272944001200 TPR motif; other site 272944001201 binding surface 272944001202 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 272944001203 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272944001204 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 272944001205 RimM N-terminal domain; Region: RimM; pfam01782 272944001206 PRC-barrel domain; Region: PRC; pfam05239 272944001207 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272944001208 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 272944001209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 272944001210 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 272944001211 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 272944001212 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 272944001213 active site 272944001214 DNA binding site [nucleotide binding] 272944001215 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 272944001216 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 272944001217 putative dimer interface [polypeptide binding]; other site 272944001218 [2Fe-2S] cluster binding site [ion binding]; other site 272944001219 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 272944001220 NADH dehydrogenase subunit D; Validated; Region: PRK06075 272944001221 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 272944001222 Rickettsial palindromic element RPE2 domain; Region: RPE2; TIGR03774 272944001223 NADH dehydrogenase subunit B; Validated; Region: PRK06411 272944001224 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 272944001225 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 272944001226 O-Antigen ligase; Region: Wzy_C; pfam04932 272944001227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 272944001228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 272944001229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 272944001230 Phage-related terminase [General function prediction only]; Region: COG5362 272944001231 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 272944001232 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272944001233 active site 272944001234 DNA binding site [nucleotide binding] 272944001235 Int/Topo IB signature motif; other site 272944001236 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 272944001237 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272944001238 NAD binding site [chemical binding]; other site 272944001239 homotetramer interface [polypeptide binding]; other site 272944001240 homodimer interface [polypeptide binding]; other site 272944001241 substrate binding site [chemical binding]; other site 272944001242 active site 272944001243 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 272944001244 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 272944001245 putative active site [active] 272944001246 catalytic triad [active] 272944001247 putative dimer interface [polypeptide binding]; other site 272944001248 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 272944001249 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 272944001250 amidase catalytic site [active] 272944001251 Zn binding residues [ion binding]; other site 272944001252 substrate binding site [chemical binding]; other site 272944001253 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272944001254 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984 272944001255 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 272944001256 TM-ABC transporter signature motif; other site 272944001257 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 272944001258 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272944001259 Walker A/P-loop; other site 272944001260 ATP binding site [chemical binding]; other site 272944001261 Q-loop/lid; other site 272944001262 ABC transporter signature motif; other site 272944001263 Walker B; other site 272944001264 D-loop; other site 272944001265 H-loop/switch region; other site 272944001266 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272944001267 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 272944001268 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 272944001269 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272944001270 active site 272944001271 nucleotide binding site [chemical binding]; other site 272944001272 HIGH motif; other site 272944001273 KMSKS motif; other site 272944001274 Predicted permeases [General function prediction only]; Region: COG0679 272944001275 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 272944001276 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272944001277 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 272944001278 putative NAD(P) binding site [chemical binding]; other site 272944001279 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 272944001280 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 272944001281 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 272944001282 putative active site [active] 272944001283 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 272944001284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272944001285 metabolite-proton symporter; Region: 2A0106; TIGR00883 272944001286 putative substrate translocation pore; other site 272944001287 malate dehydrogenase; Reviewed; Region: PRK06223 272944001288 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 272944001289 NAD(P) binding site [chemical binding]; other site 272944001290 dimer interface [polypeptide binding]; other site 272944001291 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272944001292 substrate binding site [chemical binding]; other site 272944001293 Rickettsial palindromic element RPE4 domain; Region: RPE4; TIGR03777 272944001294 TLC ATP/ADP transporter; Region: TLC; pfam03219 272944001295 CTP synthetase; Validated; Region: pyrG; PRK05380 272944001296 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272944001297 Catalytic site [active] 272944001298 active site 272944001299 UTP binding site [chemical binding]; other site 272944001300 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272944001301 active site 272944001302 putative oxyanion hole; other site 272944001303 catalytic triad [active] 272944001304 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 272944001305 Ligand binding site; other site 272944001306 oligomer interface; other site 272944001307 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272944001308 nudix motif; other site 272944001309 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 272944001310 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 272944001311 active site 272944001312 prolyl-tRNA synthetase; Provisional; Region: PRK12325 272944001313 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 272944001314 dimer interface [polypeptide binding]; other site 272944001315 motif 1; other site 272944001316 active site 272944001317 motif 2; other site 272944001318 motif 3; other site 272944001319 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272944001320 anticodon binding site; other site 272944001321 Fic family protein [Function unknown]; Region: COG3177 272944001322 Fic/DOC family; Region: Fic; pfam02661 272944001323 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272944001324 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272944001325 RuvA N terminal domain; Region: RuvA_N; pfam01330 272944001326 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272944001327 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272944001328 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272944001329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272944001330 Walker A motif; other site 272944001331 ATP binding site [chemical binding]; other site 272944001332 Walker B motif; other site 272944001333 arginine finger; other site 272944001334 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272944001335 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272944001336 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272944001337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272944001338 Walker A/P-loop; other site 272944001339 ATP binding site [chemical binding]; other site 272944001340 Q-loop/lid; other site 272944001341 ABC transporter signature motif; other site 272944001342 Walker B; other site 272944001343 D-loop; other site 272944001344 H-loop/switch region; other site 272944001345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272944001346 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272944001347 putative substrate translocation pore; other site 272944001348 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272944001349 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 272944001350 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944001351 Rickettsial palindromic element RPE5 domain; Region: RPE5; TIGR03776 272944001352 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 272944001353 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 272944001354 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 272944001355 BON domain; Region: BON; pfam04972 272944001356 BON domain; Region: BON; pfam04972 272944001357 Intracellular septation protein A [Cell division and chromosome partitioning]; Region: COG2917 272944001358 Iron permease FTR1 family; Region: FTR1; cl00475 272944001359 Uncharacterized subfamiy of Cupredoxin; Region: Cupredoxin_like_3; cd04203 272944001360 Type 1 (T1) Cu binding site [ion binding]; other site 272944001361 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272944001362 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 272944001363 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459 272944001364 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 272944001365 catalytic residues [active] 272944001366 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 272944001367 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272944001368 tandem repeat interface [polypeptide binding]; other site 272944001369 oligomer interface [polypeptide binding]; other site 272944001370 active site residues [active] 272944001371 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272944001372 trimer interface [polypeptide binding]; other site 272944001373 active site 272944001374 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272944001375 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272944001376 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272944001377 catalytic residue [active] 272944001378 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 272944001379 dimer interface [polypeptide binding]; other site 272944001380 catalytic triad [active] 272944001381 Rickettsial palindromic element RPE4 domain; Region: RPE4; TIGR03777 272944001382 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 272944001383 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 272944001384 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 272944001385 catalytic triad [active] 272944001386 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 272944001387 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 272944001388 Subunit I/III interface [polypeptide binding]; other site 272944001389 D-pathway; other site 272944001390 Subunit I/VIIc interface [polypeptide binding]; other site 272944001391 Subunit I/IV interface [polypeptide binding]; other site 272944001392 Subunit I/II interface [polypeptide binding]; other site 272944001393 Low-spin heme (heme a) binding site [chemical binding]; other site 272944001394 Subunit I/VIIa interface [polypeptide binding]; other site 272944001395 Subunit I/VIa interface [polypeptide binding]; other site 272944001396 Dimer interface; other site 272944001397 Putative water exit pathway; other site 272944001398 Binuclear center (heme a3/CuB) [ion binding]; other site 272944001399 K-pathway; other site 272944001400 Subunit I/Vb interface [polypeptide binding]; other site 272944001401 Putative proton exit pathway; other site 272944001402 Subunit I/VIb interface; other site 272944001403 Subunit I/VIc interface [polypeptide binding]; other site 272944001404 Electron transfer pathway; other site 272944001405 Subunit I/VIIIb interface [polypeptide binding]; other site 272944001406 Subunit I/VIIb interface [polypeptide binding]; other site 272944001407 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 272944001408 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272944001409 putative trimer interface [polypeptide binding]; other site 272944001410 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944001411 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 272944001412 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 272944001413 C-terminal domain of Cytochrome c Oxidase subunit II; Region: CcO_II_C; cd13912 272944001414 subunit II/VIb interface [polypeptide binding]; other site 272944001415 subunit II/VIc interface [polypeptide binding]; other site 272944001416 CuA binding site [ion binding]; other site 272944001417 subunit I/II interface [polypeptide binding]; other site 272944001418 subunit II/IV interface [polypeptide binding]; other site 272944001419 Cytidylyltransferase [Cell envelope biogenesis, outer membrane / Lipid metabolism]; Region: TagD; COG0615 272944001420 active site 272944001421 HIGH motif; other site 272944001422 nucleotide binding site [chemical binding]; other site 272944001423 putative peptidase; Provisional; Region: PRK11649 272944001424 Peptidase family M23; Region: Peptidase_M23; pfam01551 272944001425 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 272944001426 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 272944001427 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 272944001428 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01368 272944001429 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272944001430 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272944001431 cell division protein FtsW; Region: ftsW; TIGR02614 272944001432 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 272944001433 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272944001434 active site 272944001435 homodimer interface [polypeptide binding]; other site 272944001436 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272944001437 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272944001438 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 272944001439 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272944001440 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272944001441 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272944001442 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272944001443 chlorohydrolase; Provisional; Region: PRK08418 272944001444 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272944001445 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 272944001446 Outer membrane efflux protein; Region: OEP; pfam02321 272944001447 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 272944001448 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272944001449 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272944001450 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 272944001451 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 272944001452 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 272944001453 diaminopimelate epimerase; Region: DapF; TIGR00652 272944001454 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 272944001455 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 272944001456 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272944001457 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 272944001458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272944001459 FeS/SAM binding site; other site 272944001460 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272944001461 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272944001462 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272944001463 dimer interface [polypeptide binding]; other site 272944001464 motif 1; other site 272944001465 active site 272944001466 motif 2; other site 272944001467 motif 3; other site 272944001468 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272944001469 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272944001470 putative tRNA-binding site [nucleotide binding]; other site 272944001471 B3/4 domain; Region: B3_4; pfam03483 272944001472 tRNA synthetase B5 domain; Region: B5; smart00874 272944001473 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272944001474 dimer interface [polypeptide binding]; other site 272944001475 motif 1; other site 272944001476 motif 3; other site 272944001477 motif 2; other site 272944001478 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 272944001479 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272944001480 DNA polymerase III subunit beta; Validated; Region: PRK05643 272944001481 putative DNA binding surface [nucleotide binding]; other site 272944001482 dimer interface [polypeptide binding]; other site 272944001483 beta-clamp/clamp loader binding surface; other site 272944001484 beta-clamp/translesion DNA polymerase binding surface; other site 272944001485 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 272944001486 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272944001487 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272944001488 active site 272944001489 HIGH motif; other site 272944001490 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272944001491 KMSKS motif; other site 272944001492 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272944001493 tRNA binding surface [nucleotide binding]; other site 272944001494 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 272944001495 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 272944001496 catalytic site [active] 272944001497 putative active site [active] 272944001498 putative substrate binding site [chemical binding]; other site 272944001499 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 272944001500 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 272944001501 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 272944001502 active site 272944001503 dimer interface [polypeptide binding]; other site 272944001504 Rickettsial palindromic element RPE3 domain; Region: RPE3; TIGR03775 272944001505 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272944001506 HAMP domain; Region: HAMP; pfam00672 272944001507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272944001508 dimer interface [polypeptide binding]; other site 272944001509 phosphorylation site [posttranslational modification] 272944001510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272944001511 ATP binding site [chemical binding]; other site 272944001512 Mg2+ binding site [ion binding]; other site 272944001513 G-X-G motif; other site 272944001514 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272944001515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272944001516 active site 272944001517 phosphorylation site [posttranslational modification] 272944001518 intermolecular recognition site; other site 272944001519 dimerization interface [polypeptide binding]; other site 272944001520 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272944001521 DNA binding site [nucleotide binding] 272944001522 branched-chain amino acid aminotransferase; Validated; Region: PRK06606 272944001523 homodimer interface [polypeptide binding]; other site 272944001524 substrate-cofactor binding pocket; other site 272944001525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272944001526 catalytic residue [active] 272944001527 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272944001528 dimer interface [polypeptide binding]; other site 272944001529 active site 272944001530 catalytic residue [active] 272944001531 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272944001532 SmpB-tmRNA interface; other site 272944001533 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 272944001534 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 272944001535 catalytic residues [active] 272944001536 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 272944001537 CoA binding domain; Region: CoA_binding; pfam02629 272944001538 CoA-ligase; Region: Ligase_CoA; pfam00549 272944001539 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 272944001540 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 272944001541 CoA-ligase; Region: Ligase_CoA; pfam00549 272944001542 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 272944001543 putative active site [active] 272944001544 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 272944001545 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 272944001546 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 272944001547 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272944001548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 272944001549 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 272944001550 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272944001551 Predicted membrane protein [Function unknown]; Region: COG1238 272944001552 Predicted membrane protein/domain [Function unknown]; Region: COG1714 272944001553 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 272944001554 RecR protein; Region: RecR; pfam02132 272944001555 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272944001556 putative active site [active] 272944001557 putative metal-binding site [ion binding]; other site 272944001558 tetramer interface [polypeptide binding]; other site 272944001559 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 272944001560 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272944001561 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272944001562 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 272944001563 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 272944001564 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272944001565 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272944001566 Predicted permeases [General function prediction only]; Region: COG0679 272944001567 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272944001568 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272944001569 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272944001570 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272944001571 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272944001572 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 272944001573 tetramerization interface [polypeptide binding]; other site 272944001574 NAD(P) binding site [chemical binding]; other site 272944001575 catalytic residues [active] 272944001576 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272944001577 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272944001578 active site 272944001579 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272944001580 Part of AAA domain; Region: AAA_19; pfam13245 272944001581 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272944001582 Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013 272944001583 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 272944001584 tetramer interface [polypeptide binding]; other site 272944001585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272944001586 catalytic residue [active] 272944001587 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 272944001588 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 272944001589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272944001590 Walker A motif; other site 272944001591 ATP binding site [chemical binding]; other site 272944001592 Walker B motif; other site 272944001593 arginine finger; other site 272944001594 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272944001595 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272944001596 30S subunit binding site; other site 272944001597 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 272944001598 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 272944001599 trimer interface [polypeptide binding]; other site 272944001600 putative metal binding site [ion binding]; other site 272944001601 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14171 272944001602 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272944001603 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272944001604 homodimer interface [polypeptide binding]; other site 272944001605 NADP binding site [chemical binding]; other site 272944001606 substrate binding site [chemical binding]; other site 272944001607 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272944001608 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272944001609 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272944001610 Uncharacterized secreted protein [Function unknown]; Region: COG5430 272944001611 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 272944001612 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 272944001613 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 272944001614 Outer membrane usher protein; Region: Usher; pfam00577 272944001615 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 272944001616 Outer membrane usher protein; Region: Usher; pfam00577 272944001617 Uncharacterized secreted protein [Function unknown]; Region: COG5430 272944001618 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 272944001619 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272944001620 active site 272944001621 dimer interface [polypeptide binding]; other site 272944001622 catalytic residues [active] 272944001623 effector binding site; other site 272944001624 R2 peptide binding site; other site 272944001625 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 272944001626 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 272944001627 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272944001628 dimer interface [polypeptide binding]; other site 272944001629 putative radical transfer pathway; other site 272944001630 diiron center [ion binding]; other site 272944001631 tyrosyl radical; other site 272944001632 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272944001633 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 272944001634 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272944001635 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 272944001636 active site 272944001637 substrate binding site [chemical binding]; other site 272944001638 metal binding site [ion binding]; metal-binding site 272944001639 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 272944001640 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 272944001641 Walker A/P-loop; other site 272944001642 ATP binding site [chemical binding]; other site 272944001643 Q-loop/lid; other site 272944001644 ABC transporter signature motif; other site 272944001645 Walker B; other site 272944001646 D-loop; other site 272944001647 H-loop/switch region; other site 272944001648 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944001649 OstA-like protein; Region: OstA; cl00844 272944001650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 272944001651 KpsF/GutQ family protein; Region: kpsF; TIGR00393 272944001652 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 272944001653 putative active site [active] 272944001654 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 272944001655 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272944001656 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 272944001657 RNase E interface [polypeptide binding]; other site 272944001658 trimer interface [polypeptide binding]; other site 272944001659 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 272944001660 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 272944001661 RNase E interface [polypeptide binding]; other site 272944001662 trimer interface [polypeptide binding]; other site 272944001663 active site 272944001664 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272944001665 putative nucleic acid binding region [nucleotide binding]; other site 272944001666 G-X-X-G motif; other site 272944001667 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272944001668 RNA binding site [nucleotide binding]; other site 272944001669 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272944001670 16S/18S rRNA binding site [nucleotide binding]; other site 272944001671 S13e-L30e interaction site [polypeptide binding]; other site 272944001672 25S rRNA binding site [nucleotide binding]; other site 272944001673 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK14846 272944001674 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272944001675 RNA binding site [nucleotide binding]; other site 272944001676 active site 272944001677 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944001678 TLC ATP/ADP transporter; Region: TLC; pfam03219 272944001679 120 KDa Rickettsia surface antigen; Region: 120_Rick_ant; pfam12574 272944001680 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272944001681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272944001682 non-specific DNA binding site [nucleotide binding]; other site 272944001683 salt bridge; other site 272944001684 sequence-specific DNA binding site [nucleotide binding]; other site 272944001685 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 272944001686 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 272944001687 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272944001688 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 272944001689 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272944001690 active site 272944001691 catalytic residues [active] 272944001692 metal binding site [ion binding]; metal-binding site 272944001693 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944001694 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 272944001695 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 272944001696 putative active site [active] 272944001697 homotetrameric interface [polypeptide binding]; other site 272944001698 hypothetical protein; Provisional; Region: PRK06661 272944001699 intersubunit interface [polypeptide binding]; other site 272944001700 active site 272944001701 Zn2+ binding site [ion binding]; other site 272944001702 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 272944001703 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272944001704 Substrate binding site; other site 272944001705 Mg++ binding site; other site 272944001706 hypothetical protein; Validated; Region: PRK00110 272944001707 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 272944001708 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272944001709 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272944001710 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272944001711 Protein of unknown function (DUF2532); Region: DUF2532; pfam10811 272944001712 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 272944001713 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 272944001714 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 272944001715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272944001716 S-adenosylmethionine binding site [chemical binding]; other site 272944001717 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 272944001718 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272944001719 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272944001720 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272944001721 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 272944001722 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 272944001723 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 272944001724 catalytic site [active] 272944001725 putative active site [active] 272944001726 putative substrate binding site [chemical binding]; other site 272944001727 HRDC domain; Region: HRDC; cl02578 272944001728 Uncharacterized conserved protein [Function unknown]; Region: COG1723 272944001729 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 272944001730 Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893 272944001731 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 272944001732 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272944001733 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272944001734 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272944001735 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 272944001736 Na binding site [ion binding]; other site 272944001737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272944001738 dimer interface [polypeptide binding]; other site 272944001739 phosphorylation site [posttranslational modification] 272944001740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272944001741 ATP binding site [chemical binding]; other site 272944001742 G-X-G motif; other site 272944001743 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 272944001744 dimer interface [polypeptide binding]; other site 272944001745 catalytic triad [active] 272944001746 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 272944001747 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 272944001748 domain interfaces; other site 272944001749 active site 272944001750 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944001751 AAA domain; Region: AAA_14; pfam13173 272944001752 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272944001753 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 272944001754 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 272944001755 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 272944001756 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272944001757 active site 272944001758 HIGH motif; other site 272944001759 dimer interface [polypeptide binding]; other site 272944001760 KMSKS motif; other site 272944001761 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272944001762 putative acyl-acceptor binding pocket; other site 272944001763 Protein required for attachment to host cells [Cell motility and secretion]; Region: COG5622 272944001764 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 272944001765 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272944001766 HemY protein N-terminus; Region: HemY_N; pfam07219 272944001767 Rickettsial palindromic element RPE2 domain; Region: RPE2; TIGR03774 272944001768 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cl03649 272944001769 active site 272944001770 Lysine efflux permease [General function prediction only]; Region: COG1279 272944001771 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272944001772 muropeptide transporter; Reviewed; Region: ampG; cl17669 272944001773 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 272944001774 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 272944001775 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272944001776 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 272944001777 TLC ATP/ADP transporter; Region: TLC; pfam03219 272944001778 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272944001779 substrate binding pocket [chemical binding]; other site 272944001780 chain length determination region; other site 272944001781 substrate-Mg2+ binding site; other site 272944001782 catalytic residues [active] 272944001783 aspartate-rich region 1; other site 272944001784 active site lid residues [active] 272944001785 aspartate-rich region 2; other site 272944001786 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272944001787 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272944001788 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 272944001789 active site 272944001790 arginine:agmatin antiporter; Provisional; Region: PRK10644 272944001791 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272944001792 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272944001793 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 272944001794 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272944001795 trimerization site [polypeptide binding]; other site 272944001796 active site 272944001797 cysteine desulfurase; Provisional; Region: PRK14012 272944001798 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272944001799 catalytic residue [active] 272944001800 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272944001801 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272944001802 catalytic residue [active] 272944001803 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 272944001804 Rrf2 family protein; Region: rrf2_super; TIGR00738 272944001805 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 272944001806 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 272944001807 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 272944001808 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272944001809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272944001810 Coenzyme A binding pocket [chemical binding]; other site 272944001811 Predicted acetyltransferase [General function prediction only]; Region: COG5628 272944001812 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 272944001813 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 272944001814 homotetramer interface [polypeptide binding]; other site 272944001815 FMN binding site [chemical binding]; other site 272944001816 homodimer contacts [polypeptide binding]; other site 272944001817 putative active site [active] 272944001818 putative substrate binding site [chemical binding]; other site 272944001819 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272944001820 oligomer interface [polypeptide binding]; other site 272944001821 active site residues [active] 272944001822 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 272944001823 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 272944001824 RNA binding site [nucleotide binding]; other site 272944001825 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272944001826 RNA binding site [nucleotide binding]; other site 272944001827 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272944001828 RNA binding site [nucleotide binding]; other site 272944001829 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272944001830 RNA binding site [nucleotide binding]; other site 272944001831 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272944001832 RNA binding site [nucleotide binding]; other site 272944001833 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272944001834 RNA binding site [nucleotide binding]; other site 272944001835 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 272944001836 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272944001837 AAA domain; Region: AAA_17; pfam13207 272944001838 CMP-binding site; other site 272944001839 The sites determining sugar specificity; other site 272944001840 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 272944001841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3022 272944001842 Bacterial nucleoid DNA-binding protein [DNA replication, recombination, and repair]; Region: HimA; COG0776 272944001843 DNA binding site [nucleotide binding] 272944001844 dimer interface [polypeptide binding]; other site 272944001845 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 272944001846 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272944001847 tandem repeat interface [polypeptide binding]; other site 272944001848 oligomer interface [polypeptide binding]; other site 272944001849 active site residues [active] 272944001850 transcription termination factor Rho; Provisional; Region: rho; PRK09376 272944001851 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 272944001852 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 272944001853 RNA binding site [nucleotide binding]; other site 272944001854 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 272944001855 multimer interface [polypeptide binding]; other site 272944001856 Walker A motif; other site 272944001857 ATP binding site [chemical binding]; other site 272944001858 Walker B motif; other site 272944001859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272944001860 S-adenosylmethionine binding site [chemical binding]; other site 272944001861 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272944001862 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272944001863 DHH family; Region: DHH; pfam01368 272944001864 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272944001865 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272944001866 RF-1 domain; Region: RF-1; pfam00472 272944001867 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272944001868 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 272944001869 E3 interaction surface; other site 272944001870 lipoyl attachment site [posttranslational modification]; other site 272944001871 e3 binding domain; Region: E3_binding; pfam02817 272944001872 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272944001873 translation initiation factor IF-3; Region: infC; TIGR00168 272944001874 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272944001875 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272944001876 Predicted membrane protein [Function unknown]; Region: COG5346 272944001877 Uncharacterized conserved protein [Function unknown]; Region: COG5449 272944001878 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 272944001879 Uncharacterized conserved protein [Function unknown]; Region: COG5448 272944001880 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 272944001881 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 272944001882 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 272944001883 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 272944001884 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 272944001885 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 272944001886 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272944001887 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272944001888 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272944001889 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272944001890 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272944001891 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 272944001892 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 272944001893 conserved cys residue [active] 272944001894 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272944001895 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 272944001896 GSH binding site (G-site) [chemical binding]; other site 272944001897 C-terminal domain interface [polypeptide binding]; other site 272944001898 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 272944001899 N-terminal domain interface [polypeptide binding]; other site 272944001900 dimer interface [polypeptide binding]; other site 272944001901 substrate binding pocket (H-site) [chemical binding]; other site 272944001902 pyruvate phosphate dikinase; Provisional; Region: PRK09279 272944001903 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272944001904 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272944001905 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272944001906 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 272944001907 metal binding site [ion binding]; metal-binding site 272944001908 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 272944001909 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 272944001910 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272944001911 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 272944001912 dimer interface [polypeptide binding]; other site 272944001913 allosteric magnesium binding site [ion binding]; other site 272944001914 active site 272944001915 aspartate-rich active site metal binding site; other site 272944001916 Schiff base residues; other site 272944001917 primosome assembly protein PriA; Validated; Region: PRK05580 272944001918 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272944001919 ATP binding site [chemical binding]; other site 272944001920 putative Mg++ binding site [ion binding]; other site 272944001921 helicase superfamily c-terminal domain; Region: HELICc; smart00490 272944001922 aromatic acid decarboxylase; Validated; Region: PRK05920 272944001923 replicative DNA helicase; Provisional; Region: PRK09165 272944001924 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272944001925 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272944001926 Walker A motif; other site 272944001927 ATP binding site [chemical binding]; other site 272944001928 Walker B motif; other site 272944001929 DNA binding loops [nucleotide binding] 272944001930 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 272944001931 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272944001932 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272944001933 RNA binding surface [nucleotide binding]; other site 272944001934 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 272944001935 active site 272944001936 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272944001937 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272944001938 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272944001939 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272944001940 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272944001941 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272944001942 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272944001943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272944001944 S-adenosylmethionine binding site [chemical binding]; other site 272944001945 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944001946 DNA repair protein RadA; Provisional; Region: PRK11823 272944001947 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 272944001948 Walker A motif/ATP binding site; other site 272944001949 ATP binding site [chemical binding]; other site 272944001950 Walker B motif; other site 272944001951 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272944001952 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 272944001953 Recombination protein O N terminal; Region: RecO_N; pfam11967 272944001954 Recombination protein O C terminal; Region: RecO_C; pfam02565 272944001955 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 272944001956 Glycoprotease family; Region: Peptidase_M22; pfam00814 272944001957 translation initiation factor IF-2; Validated; Region: infB; PRK05306 272944001958 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272944001959 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272944001960 G1 box; other site 272944001961 putative GEF interaction site [polypeptide binding]; other site 272944001962 GTP/Mg2+ binding site [chemical binding]; other site 272944001963 Switch I region; other site 272944001964 G2 box; other site 272944001965 G3 box; other site 272944001966 Switch II region; other site 272944001967 G4 box; other site 272944001968 G5 box; other site 272944001969 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272944001970 Translation-initiation factor 2; Region: IF-2; pfam11987 272944001971 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272944001972 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 272944001973 NusA N-terminal domain; Region: NusA_N; pfam08529 272944001974 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272944001975 RNA binding site [nucleotide binding]; other site 272944001976 homodimer interface [polypeptide binding]; other site 272944001977 NusA-like KH domain; Region: KH_5; pfam13184 272944001978 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272944001979 G-X-X-G motif; other site 272944001980 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 272944001981 Sm and related proteins; Region: Sm_like; cl00259 272944001982 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 272944001983 putative oligomer interface [polypeptide binding]; other site 272944001984 putative RNA binding site [nucleotide binding]; other site 272944001985 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 272944001986 NAD binding pocket [chemical binding]; other site 272944001987 Rrf2 family protein; Region: rrf2_super; TIGR00738 272944001988 Transcriptional regulator; Region: Rrf2; cl17282 272944001989 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 272944001990 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272944001991 RNA binding surface [nucleotide binding]; other site 272944001992 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 272944001993 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272944001994 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272944001995 active site 272944001996 HIGH motif; other site 272944001997 dimer interface [polypeptide binding]; other site 272944001998 KMSKS motif; other site 272944001999 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272944002000 RNA binding surface [nucleotide binding]; other site 272944002001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 272944002002 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 272944002003 metabolite-proton symporter; Region: 2A0106; TIGR00883 272944002004 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 272944002005 active site 272944002006 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 272944002007 MG2 domain; Region: A2M_N; pfam01835 272944002008 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 272944002009 Alpha-2-macroglobulin family; Region: A2M; pfam00207 272944002010 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 272944002011 surface patch; other site 272944002012 thioester region; other site 272944002013 specificity defining residues; other site 272944002014 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 272944002015 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl18948 272944002016 oxyanion hole (OAH) forming residues; other site 272944002017 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 272944002018 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl18948 272944002019 substrate binding site [chemical binding]; other site 272944002020 oxyanion hole (OAH) forming residues; other site 272944002021 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 272944002022 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272944002023 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 272944002024 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272944002025 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 272944002026 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272944002027 active site 272944002028 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 272944002029 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 272944002030 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944002031 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK06617 272944002032 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 272944002033 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272944002034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272944002035 active site 272944002036 phosphorylation site [posttranslational modification] 272944002037 intermolecular recognition site; other site 272944002038 dimerization interface [polypeptide binding]; other site 272944002039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272944002040 Walker A motif; other site 272944002041 ATP binding site [chemical binding]; other site 272944002042 Walker B motif; other site 272944002043 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272944002044 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272944002045 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272944002046 DNA repair protein RecN; Region: recN; TIGR00634 272944002047 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 272944002048 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272944002049 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272944002050 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272944002051 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272944002052 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272944002053 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 272944002054 MraW methylase family; Region: Methyltransf_5; cl17771 272944002055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272944002056 S-adenosylmethionine binding site [chemical binding]; other site 272944002057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 272944002058 MraZ protein; Region: MraZ; pfam02381 272944002059 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272944002060 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 272944002061 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 272944002062 Na binding site [ion binding]; other site 272944002063 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272944002064 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272944002065 GIY-YIG motif/motif A; other site 272944002066 active site 272944002067 catalytic site [active] 272944002068 putative DNA binding site [nucleotide binding]; other site 272944002069 metal binding site [ion binding]; metal-binding site 272944002070 UvrB/uvrC motif; Region: UVR; pfam02151 272944002071 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272944002072 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272944002073 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 272944002074 A new structural DNA glycosylase; Region: AlkD_like; cd06561 272944002075 active site 272944002076 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272944002077 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272944002078 DNA binding site [nucleotide binding] 272944002079 active site 272944002080 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 272944002081 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272944002082 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 272944002083 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 272944002084 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272944002085 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272944002086 DNA binding site [nucleotide binding] 272944002087 active site 272944002088 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 272944002089 Ankyrin repeat; Region: Ank; pfam00023 272944002090 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 272944002091 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272944002092 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272944002093 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 272944002094 SEC-C motif; Region: SEC-C; pfam02810 272944002095 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 272944002096 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272944002097 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 272944002098 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 272944002099 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 272944002100 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272944002101 hinge; other site 272944002102 active site 272944002103 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 272944002104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272944002105 ATP binding site [chemical binding]; other site 272944002106 Mg2+ binding site [ion binding]; other site 272944002107 G-X-G motif; other site 272944002108 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272944002109 anchoring element; other site 272944002110 dimer interface [polypeptide binding]; other site 272944002111 ATP binding site [chemical binding]; other site 272944002112 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272944002113 active site 272944002114 putative metal-binding site [ion binding]; other site 272944002115 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272944002116 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 272944002117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272944002118 active site 272944002119 motif I; other site 272944002120 motif II; other site 272944002121 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272944002122 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 272944002123 MgtE intracellular N domain; Region: MgtE_N; pfam03448 272944002124 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 272944002125 Divalent cation transporter; Region: MgtE; cl00786 272944002126 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272944002127 HD domain; Region: HD_4; pfam13328 272944002128 metabolite-proton symporter; Region: 2A0106; TIGR00883 272944002129 Rickettsial palindromic element RPE5 domain; Region: RPE5; TIGR03776 272944002130 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 272944002131 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 272944002132 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 272944002133 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 272944002134 Cu(I) binding site [ion binding]; other site 272944002135 Cytochrome c-type biogenesis protein CcmE [Posttranslational modification, protein turnover, chaperones]; Region: CcmE; COG2332 272944002136 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 272944002137 dimer interface [polypeptide binding]; other site 272944002138 substrate binding site [chemical binding]; other site 272944002139 metal binding sites [ion binding]; metal-binding site 272944002140 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944002141 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 272944002142 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 272944002143 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 272944002144 TraX protein; Region: TraX; pfam05857 272944002145 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 272944002146 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272944002147 ssDNA binding site; other site 272944002148 generic binding surface II; other site 272944002149 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272944002150 ATP binding site [chemical binding]; other site 272944002151 putative Mg++ binding site [ion binding]; other site 272944002152 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272944002153 nucleotide binding region [chemical binding]; other site 272944002154 ATP-binding site [chemical binding]; other site 272944002155 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 272944002156 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 272944002157 Coenzyme A transferase; Region: CoA_trans; cl17247 272944002158 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 272944002159 V-type ATP synthase subunit I; Validated; Region: PRK05771 272944002160 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272944002161 Mg++ binding site [ion binding]; other site 272944002162 putative catalytic motif [active] 272944002163 putative substrate binding site [chemical binding]; other site 272944002164 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 272944002165 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272944002166 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272944002167 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272944002168 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 272944002169 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272944002170 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272944002171 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272944002172 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272944002173 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 272944002174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272944002175 ATP binding site [chemical binding]; other site 272944002176 putative Mg++ binding site [ion binding]; other site 272944002177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272944002178 nucleotide binding region [chemical binding]; other site 272944002179 ATP-binding site [chemical binding]; other site 272944002180 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 272944002181 Uncharacterized conserved protein [Function unknown]; Region: COG2938 272944002182 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 272944002183 active site residue [active] 272944002184 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 272944002185 DnaA N-terminal domain; Region: DnaA_N; pfam11638 272944002186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272944002187 Walker A motif; other site 272944002188 ATP binding site [chemical binding]; other site 272944002189 Walker B motif; other site 272944002190 arginine finger; other site 272944002191 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272944002192 DnaA box-binding interface [nucleotide binding]; other site 272944002193 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 272944002194 active site 272944002195 nucleophile elbow; other site 272944002196 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 272944002197 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 272944002198 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 272944002199 HEPN domain; Region: HEPN; cl00824 272944002200 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 272944002201 active site 272944002202 NTP binding site [chemical binding]; other site 272944002203 metal binding triad [ion binding]; metal-binding site 272944002204 GTP-binding protein YchF; Reviewed; Region: PRK09601 272944002205 YchF GTPase; Region: YchF; cd01900 272944002206 G1 box; other site 272944002207 GTP/Mg2+ binding site [chemical binding]; other site 272944002208 Switch I region; other site 272944002209 G2 box; other site 272944002210 Switch II region; other site 272944002211 G3 box; other site 272944002212 G4 box; other site 272944002213 G5 box; other site 272944002214 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272944002215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272944002216 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272944002217 putative active site [active] 272944002218 catalytic residue [active] 272944002219 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 272944002220 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 272944002221 5S rRNA interface [nucleotide binding]; other site 272944002222 CTC domain interface [polypeptide binding]; other site 272944002223 L16 interface [polypeptide binding]; other site 272944002224 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 272944002225 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 272944002226 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 272944002227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272944002228 FeS/SAM binding site; other site 272944002229 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272944002230 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272944002231 23S rRNA binding site [nucleotide binding]; other site 272944002232 L21 binding site [polypeptide binding]; other site 272944002233 L13 binding site [polypeptide binding]; other site 272944002234 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 272944002235 ribonuclease P; Reviewed; Region: rnpA; PRK01492 272944002236 Protein of unknown function (DUF416); Region: DUF416; cl01166 272944002237 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272944002238 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 272944002239 Cl binding site [ion binding]; other site 272944002240 oligomer interface [polypeptide binding]; other site 272944002241 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272944002242 Phosphotransferase enzyme family; Region: APH; pfam01636 272944002243 substrate binding site [chemical binding]; other site 272944002244 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 272944002245 Serpentine type 7TM GPCR chemoreceptor Srh; Region: 7TM_GPCR_Srh; cl11665 272944002246 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272944002247 dimerization interface [polypeptide binding]; other site 272944002248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272944002249 dimer interface [polypeptide binding]; other site 272944002250 phosphorylation site [posttranslational modification] 272944002251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272944002252 ATP binding site [chemical binding]; other site 272944002253 Mg2+ binding site [ion binding]; other site 272944002254 G-X-G motif; other site 272944002255 Ribosomal protein S21 [Translation, ribosomal structure and biogenesis]; Region: RpsU; COG0828 272944002256 Uncharacterized conserved protein [Function unknown]; Region: COG5590 272944002257 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 272944002258 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272944002259 active site 272944002260 HIGH motif; other site 272944002261 nucleotide binding site [chemical binding]; other site 272944002262 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272944002263 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272944002264 active site 272944002265 KMSKS motif; other site 272944002266 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 272944002267 tRNA binding surface [nucleotide binding]; other site 272944002268 anticodon binding site; other site 272944002269 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272944002270 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272944002271 Ankyrin repeat; Region: Ank; pfam00023 272944002272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272944002273 TPR motif; other site 272944002274 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 272944002275 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272944002276 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272944002277 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272944002278 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272944002279 carboxyltransferase (CT) interaction site; other site 272944002280 biotinylation site [posttranslational modification]; other site 272944002281 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 272944002282 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 272944002283 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 272944002284 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 272944002285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272944002286 putative substrate translocation pore; other site 272944002287 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272944002288 putative acyl-acceptor binding pocket; other site 272944002289 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 272944002290 acyl-activating enzyme (AAE) consensus motif; other site 272944002291 putative AMP binding site [chemical binding]; other site 272944002292 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 272944002293 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272944002294 ABC-ATPase subunit interface; other site 272944002295 dimer interface [polypeptide binding]; other site 272944002296 putative PBP binding regions; other site 272944002297 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 272944002298 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944002299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272944002300 S-adenosylmethionine binding site [chemical binding]; other site 272944002301 glutamyl-tRNA synthetase; Provisional; Region: gltX; PRK14895 272944002302 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272944002303 active site 272944002304 HIGH motif; other site 272944002305 KMSKS motif; other site 272944002306 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944002307 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 272944002308 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 272944002309 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272944002310 ring oligomerisation interface [polypeptide binding]; other site 272944002311 ATP/Mg binding site [chemical binding]; other site 272944002312 stacking interactions; other site 272944002313 hinge regions; other site 272944002314 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272944002315 oligomerisation interface [polypeptide binding]; other site 272944002316 mobile loop; other site 272944002317 roof hairpin; other site 272944002318 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272944002319 active site 272944002320 ribonuclease PH; Reviewed; Region: rph; PRK00173 272944002321 Ribonuclease PH; Region: RNase_PH_bact; cd11362 272944002322 hexamer interface [polypeptide binding]; other site 272944002323 active site 272944002324 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272944002325 dimer interface [polypeptide binding]; other site 272944002326 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272944002327 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272944002328 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 272944002329 hypothetical protein; Validated; Region: PRK06620 272944002330 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272944002331 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 272944002332 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272944002333 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272944002334 alphaNTD - beta interaction site [polypeptide binding]; other site 272944002335 alphaNTD homodimer interface [polypeptide binding]; other site 272944002336 alphaNTD - beta' interaction site [polypeptide binding]; other site 272944002337 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272944002338 30S ribosomal protein S11; Validated; Region: PRK05309 272944002339 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272944002340 adenylate kinase; Reviewed; Region: adk; PRK00279 272944002341 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272944002342 AMP-binding site [chemical binding]; other site 272944002343 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272944002344 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272944002345 SecY translocase; Region: SecY; pfam00344 272944002346 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272944002347 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 272944002348 23S rRNA binding site [nucleotide binding]; other site 272944002349 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272944002350 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272944002351 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272944002352 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272944002353 23S rRNA interface [nucleotide binding]; other site 272944002354 L21e interface [polypeptide binding]; other site 272944002355 5S rRNA interface [nucleotide binding]; other site 272944002356 L27 interface [polypeptide binding]; other site 272944002357 L5 interface [polypeptide binding]; other site 272944002358 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272944002359 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272944002360 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272944002361 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272944002362 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 272944002363 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272944002364 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272944002365 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272944002366 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272944002367 RNA binding site [nucleotide binding]; other site 272944002368 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272944002369 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272944002370 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272944002371 putative translocon interaction site; other site 272944002372 signal recognition particle (SRP54) interaction site; other site 272944002373 L23 interface [polypeptide binding]; other site 272944002374 trigger factor interaction site; other site 272944002375 23S rRNA interface [nucleotide binding]; other site 272944002376 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272944002377 23S rRNA interface [nucleotide binding]; other site 272944002378 5S rRNA interface [nucleotide binding]; other site 272944002379 putative antibiotic binding site [chemical binding]; other site 272944002380 L25 interface [polypeptide binding]; other site 272944002381 L27 interface [polypeptide binding]; other site 272944002382 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272944002383 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272944002384 G-X-X-G motif; other site 272944002385 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272944002386 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272944002387 putative translocon binding site; other site 272944002388 protein-rRNA interface [nucleotide binding]; other site 272944002389 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272944002390 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272944002391 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272944002392 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272944002393 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 272944002394 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272944002395 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272944002396 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272944002397 elongation factor Tu; Reviewed; Region: PRK00049 272944002398 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272944002399 G1 box; other site 272944002400 GEF interaction site [polypeptide binding]; other site 272944002401 GTP/Mg2+ binding site [chemical binding]; other site 272944002402 Switch I region; other site 272944002403 G2 box; other site 272944002404 G3 box; other site 272944002405 Switch II region; other site 272944002406 G4 box; other site 272944002407 G5 box; other site 272944002408 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272944002409 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272944002410 Antibiotic Binding Site [chemical binding]; other site 272944002411 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272944002412 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 272944002413 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272944002414 fumarate hydratase; Reviewed; Region: fumC; PRK00485 272944002415 Class II fumarases; Region: Fumarase_classII; cd01362 272944002416 active site 272944002417 tetramer interface [polypeptide binding]; other site 272944002418 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 272944002419 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 272944002420 putative active site [active] 272944002421 homotetrameric interface [polypeptide binding]; other site 272944002422 cell division protein FtsZ; Validated; Region: PRK09330 272944002423 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272944002424 nucleotide binding site [chemical binding]; other site 272944002425 SulA interaction site; other site 272944002426 Serine protease inhibitor ecotin [General function prediction only]; Region: Eco; COG4574 272944002427 primary substrate binding site; other site 272944002428 inhibition loop; other site 272944002429 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 272944002430 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 272944002431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272944002432 putative substrate translocation pore; other site 272944002433 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272944002434 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 272944002435 ATP binding site [chemical binding]; other site 272944002436 Mg++ binding site [ion binding]; other site 272944002437 motif III; other site 272944002438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272944002439 nucleotide binding region [chemical binding]; other site 272944002440 ATP-binding site [chemical binding]; other site 272944002441 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272944002442 DNA-binding site [nucleotide binding]; DNA binding site 272944002443 RNA-binding motif; other site 272944002444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272944002445 S-adenosylmethionine binding site [chemical binding]; other site 272944002446 Rickettsial palindromic element RPE2 domain; Region: RPE2; TIGR03774 272944002447 SurA N-terminal domain; Region: SurA_N_3; cl07813 272944002448 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 272944002449 Organic solvent tolerance protein; Region: OstA_C; pfam04453 272944002450 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 272944002451 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272944002452 generic binding surface II; other site 272944002453 generic binding surface I; other site 272944002454 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272944002455 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 272944002456 putative catalytic site [active] 272944002457 putative phosphate binding site [ion binding]; other site 272944002458 active site 272944002459 metal binding site A [ion binding]; metal-binding site 272944002460 DNA binding site [nucleotide binding] 272944002461 putative AP binding site [nucleotide binding]; other site 272944002462 putative metal binding site B [ion binding]; other site 272944002463 Uncharacterized conserved protein [Function unknown]; Region: COG4095 272944002464 GTP-binding protein Der; Reviewed; Region: PRK00093 272944002465 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272944002466 G1 box; other site 272944002467 GTP/Mg2+ binding site [chemical binding]; other site 272944002468 Switch I region; other site 272944002469 G2 box; other site 272944002470 Switch II region; other site 272944002471 G3 box; other site 272944002472 G4 box; other site 272944002473 G5 box; other site 272944002474 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272944002475 G1 box; other site 272944002476 GTP/Mg2+ binding site [chemical binding]; other site 272944002477 Switch I region; other site 272944002478 G2 box; other site 272944002479 G3 box; other site 272944002480 Switch II region; other site 272944002481 G4 box; other site 272944002482 G5 box; other site 272944002483 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 272944002484 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272944002485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272944002486 Walker A motif; other site 272944002487 ATP binding site [chemical binding]; other site 272944002488 Walker B motif; other site 272944002489 arginine finger; other site 272944002490 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 272944002491 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 272944002492 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 272944002493 active site 272944002494 ATP binding site [chemical binding]; other site 272944002495 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 272944002496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272944002497 S-adenosylmethionine binding site [chemical binding]; other site 272944002498 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272944002499 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272944002500 DNA binding site [nucleotide binding] 272944002501 catalytic residue [active] 272944002502 H2TH interface [polypeptide binding]; other site 272944002503 putative catalytic residues [active] 272944002504 turnover-facilitating residue; other site 272944002505 intercalation triad [nucleotide binding]; other site 272944002506 8OG recognition residue [nucleotide binding]; other site 272944002507 putative reading head residues; other site 272944002508 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272944002509 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272944002510 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944002511 Rickettsial palindromic element RPE3 domain; Region: RPE3; TIGR03775 272944002512 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 272944002513 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272944002514 active site 272944002515 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 272944002516 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272944002517 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 272944002518 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 272944002519 Protein of unknown function (DUF511); Region: DUF511; cl01114 272944002520 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 272944002521 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272944002522 active site 272944002523 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 272944002524 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272944002525 active site 272944002526 HIGH motif; other site 272944002527 KMSKS motif; other site 272944002528 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272944002529 tRNA binding surface [nucleotide binding]; other site 272944002530 anticodon binding site; other site 272944002531 thymidylate kinase; Validated; Region: tmk; PRK00698 272944002532 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272944002533 TMP-binding site; other site 272944002534 ATP-binding site [chemical binding]; other site 272944002535 metabolite-proton symporter; Region: 2A0106; TIGR00883 272944002536 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 272944002537 putative active site [active] 272944002538 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 272944002539 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 272944002540 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272944002541 active site 272944002542 nucleotide binding site [chemical binding]; other site 272944002543 HIGH motif; other site 272944002544 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272944002545 KMSKS motif; other site 272944002546 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272944002547 tRNA binding surface [nucleotide binding]; other site 272944002548 anticodon binding site; other site 272944002549 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 272944002550 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 272944002551 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 272944002552 RmuC family; Region: RmuC; pfam02646 272944002553 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 272944002554 Glycosyltransferase involved in LPS biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG3306 272944002555 DoxX-like family; Region: DoxX_3; pfam13781 272944002556 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 272944002557 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272944002558 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272944002559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272944002560 Walker A motif; other site 272944002561 ATP binding site [chemical binding]; other site 272944002562 Walker B motif; other site 272944002563 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272944002564 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272944002565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272944002566 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 272944002567 Ligand Binding Site [chemical binding]; other site 272944002568 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 272944002569 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 272944002570 HicB family; Region: HicB; pfam05534 272944002571 YcfA-like protein; Region: YcfA; pfam07927 272944002572 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 272944002573 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272944002574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272944002575 Walker A/P-loop; other site 272944002576 ATP binding site [chemical binding]; other site 272944002577 Q-loop/lid; other site 272944002578 ABC transporter signature motif; other site 272944002579 Walker B; other site 272944002580 D-loop; other site 272944002581 H-loop/switch region; other site 272944002582 Protein of unknown function (DUF2673); Region: DUF2673; pfam10880 272944002583 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 272944002584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272944002585 putative substrate translocation pore; other site 272944002586 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 272944002587 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272944002588 FtsX-like permease family; Region: FtsX; pfam02687 272944002589 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272944002590 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272944002591 Walker A/P-loop; other site 272944002592 ATP binding site [chemical binding]; other site 272944002593 Q-loop/lid; other site 272944002594 ABC transporter signature motif; other site 272944002595 Walker B; other site 272944002596 D-loop; other site 272944002597 H-loop/switch region; other site 272944002598 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 272944002599 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 272944002600 Domain of unknown function DUF21; Region: DUF21; pfam01595 272944002601 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272944002602 Transporter associated domain; Region: CorC_HlyC; smart01091 272944002603 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 272944002604 Rickettsia outer membrane protein B; Region: rOmpB; pfam12334 272944002605 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 272944002606 Autotransporter beta-domain; Region: Autotransporter; smart00869 272944002607 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 272944002608 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272944002609 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272944002610 DNA binding residues [nucleotide binding] 272944002611 Bacterial nucleoid DNA-binding protein [DNA replication, recombination, and repair]; Region: HimA; COG0776 272944002612 DNA binding site [nucleotide binding] 272944002613 dimer interface [polypeptide binding]; other site 272944002614 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 272944002615 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272944002616 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272944002617 catalytic triad [active] 272944002618 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 272944002619 putative acyl-acceptor binding pocket; other site 272944002620 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 272944002621 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272944002622 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272944002623 Peptidase family M23; Region: Peptidase_M23; pfam01551 272944002624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272944002625 Virulence protein RhuM family; Region: Virulence_RhuM; cl19850 272944002626 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272944002627 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272944002628 nucleotide binding pocket [chemical binding]; other site 272944002629 K-X-D-G motif; other site 272944002630 catalytic site [active] 272944002631 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272944002632 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272944002633 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 272944002634 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272944002635 Dimer interface [polypeptide binding]; other site 272944002636 BRCT sequence motif; other site 272944002637 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 272944002638 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 272944002639 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272944002640 HD domain; Region: HD_4; pfam13328 272944002641 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272944002642 HD domain; Region: HD_4; pfam13328 272944002643 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 272944002644 mce related protein; Region: MCE; pfam02470 272944002645 hypothetical protein; Provisional; Region: PRK06630 272944002646 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 272944002647 RNA/DNA hybrid binding site [nucleotide binding]; other site 272944002648 active site 272944002649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 272944002650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 272944002651 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272944002652 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272944002653 CoA-binding site [chemical binding]; other site 272944002654 ATP-binding [chemical binding]; other site 272944002655 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 272944002656 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 272944002657 active site 272944002658 catalytic site [active] 272944002659 substrate binding site [chemical binding]; other site 272944002660 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 272944002661 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272944002662 Part of AAA domain; Region: AAA_19; pfam13245 272944002663 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272944002664 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272944002665 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 272944002666 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 272944002667 AAA domain; Region: AAA_12; pfam13087 272944002668 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 272944002669 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272944002670 active site 272944002671 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 272944002672 active site 272944002673 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 272944002674 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272944002675 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 272944002676 TLC ATP/ADP transporter; Region: TLC; pfam03219 272944002677 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 272944002678 nudix motif; other site 272944002679 FOG: CBS domain [General function prediction only]; Region: COG0517 272944002680 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272944002681 Transporter associated domain; Region: CorC_HlyC; smart01091 272944002682 metal-binding heat shock protein; Provisional; Region: PRK00016 272944002683 PemK-like protein; Region: PemK; pfam02452 272944002684 lipoyl synthase; Provisional; Region: PRK05481 272944002685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272944002686 FeS/SAM binding site; other site 272944002687 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272944002688 dimer interface [polypeptide binding]; other site 272944002689 active site 272944002690 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272944002691 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 272944002692 folate binding site [chemical binding]; other site 272944002693 Predicted esterase [General function prediction only]; Region: COG0400 272944002694 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272944002695 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 272944002696 putative GSH binding site [chemical binding]; other site 272944002697 catalytic residues [active] 272944002698 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272944002699 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272944002700 minor groove reading motif; other site 272944002701 helix-hairpin-helix signature motif; other site 272944002702 substrate binding pocket [chemical binding]; other site 272944002703 active site 272944002704 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272944002705 Predicted small secreted protein [Function unknown]; Region: COG5510 272944002706 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 272944002707 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 272944002708 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 272944002709 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272944002710 putative SAM binding site [chemical binding]; other site 272944002711 putative homodimer interface [polypeptide binding]; other site 272944002712 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 272944002713 putative ligand binding site [chemical binding]; other site 272944002714 twin arginine translocase protein A; Provisional; Region: tatA; PRK01470 272944002715 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 272944002716 tetramer interfaces [polypeptide binding]; other site 272944002717 binuclear metal-binding site [ion binding]; other site 272944002718 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272944002719 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272944002720 aspartate kinase; Reviewed; Region: PRK06635 272944002721 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 272944002722 putative nucleotide binding site [chemical binding]; other site 272944002723 putative catalytic residues [active] 272944002724 putative Mg ion binding site [ion binding]; other site 272944002725 putative aspartate binding site [chemical binding]; other site 272944002726 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272944002727 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 272944002728 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cl01007 272944002729 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 272944002730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272944002731 metabolite-proton symporter; Region: 2A0106; TIGR00883 272944002732 putative substrate translocation pore; other site 272944002733 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 272944002734 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944002735 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 272944002736 Helix-turn-helix domain; Region: HTH_25; pfam13413 272944002737 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 272944002738 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 272944002739 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 272944002740 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272944002741 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272944002742 G1 box; other site 272944002743 GTP/Mg2+ binding site [chemical binding]; other site 272944002744 Switch I region; other site 272944002745 G2 box; other site 272944002746 Switch II region; other site 272944002747 G3 box; other site 272944002748 G4 box; other site 272944002749 G5 box; other site 272944002750 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272944002751 Mediator complex subunit 3 fungal; Region: Med3; pfam11593 272944002752 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 272944002753 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272944002754 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272944002755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272944002756 recombinase A; Provisional; Region: recA; PRK09354 272944002757 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272944002758 hexamer interface [polypeptide binding]; other site 272944002759 Walker A motif; other site 272944002760 ATP binding site [chemical binding]; other site 272944002761 Walker B motif; other site 272944002762 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 272944002763 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272944002764 homotetramer interface [polypeptide binding]; other site 272944002765 NAD(P) binding site [chemical binding]; other site 272944002766 homodimer interface [polypeptide binding]; other site 272944002767 active site 272944002768 Phosphopantetheine attachment site; Region: PP-binding; cl09936 272944002769 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 272944002770 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272944002771 dimer interface [polypeptide binding]; other site 272944002772 active site 272944002773 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272944002774 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272944002775 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272944002776 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272944002777 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272944002778 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 272944002779 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272944002780 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272944002781 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944002782 Guanylate kinase; Region: Guanylate_kin; pfam00625 272944002783 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272944002784 catalytic site [active] 272944002785 G-X2-G-X-G-K; other site 272944002786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272944002787 non-specific DNA binding site [nucleotide binding]; other site 272944002788 salt bridge; other site 272944002789 sequence-specific DNA binding site [nucleotide binding]; other site 272944002790 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 272944002791 rod shape-determining protein MreB; Provisional; Region: PRK13927 272944002792 MreB and similar proteins; Region: MreB_like; cd10225 272944002793 nucleotide binding site [chemical binding]; other site 272944002794 Mg binding site [ion binding]; other site 272944002795 putative protofilament interaction site [polypeptide binding]; other site 272944002796 RodZ interaction site [polypeptide binding]; other site 272944002797 Predicted permeases [General function prediction only]; Region: COG0795 272944002798 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272944002799 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272944002800 ligand binding site [chemical binding]; other site 272944002801 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944002802 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272944002803 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272944002804 dimer interface [polypeptide binding]; other site 272944002805 active site 272944002806 CoA binding pocket [chemical binding]; other site 272944002807 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 272944002808 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 272944002809 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272944002810 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272944002811 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 272944002812 DNA polymerase I; Provisional; Region: PRK05755 272944002813 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272944002814 active site 272944002815 metal binding site 1 [ion binding]; metal-binding site 272944002816 putative 5' ssDNA interaction site; other site 272944002817 metal binding site 3; metal-binding site 272944002818 metal binding site 2 [ion binding]; metal-binding site 272944002819 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272944002820 putative DNA binding site [nucleotide binding]; other site 272944002821 putative metal binding site [ion binding]; other site 272944002822 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 272944002823 active site 272944002824 substrate binding site [chemical binding]; other site 272944002825 catalytic site [active] 272944002826 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272944002827 active site 272944002828 DNA binding site [nucleotide binding] 272944002829 catalytic site [active] 272944002830 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 272944002831 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 272944002832 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 272944002833 putative active site [active] 272944002834 putative PHP Thumb interface [polypeptide binding]; other site 272944002835 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272944002836 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272944002837 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272944002838 generic binding surface I; other site 272944002839 generic binding surface II; other site 272944002840 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 272944002841 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 272944002842 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 272944002843 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 272944002844 Protein of unknown function; Region: DUF3971; pfam13116 272944002845 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272944002846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272944002847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272944002848 putative substrate translocation pore; other site 272944002849 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 272944002850 seryl-tRNA synthetase; Provisional; Region: PRK05431 272944002851 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272944002852 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272944002853 dimer interface [polypeptide binding]; other site 272944002854 active site 272944002855 motif 1; other site 272944002856 motif 2; other site 272944002857 motif 3; other site 272944002858 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 272944002859 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 272944002860 Integral membrane protein TerC family; Region: TerC; cl10468 272944002861 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 272944002862 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272944002863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272944002864 S-adenosylmethionine binding site [chemical binding]; other site 272944002865 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 272944002866 Predicted transcriptional regulator [Transcription]; Region: COG2944 272944002867 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272944002868 salt bridge; other site 272944002869 non-specific DNA binding site [nucleotide binding]; other site 272944002870 sequence-specific DNA binding site [nucleotide binding]; other site 272944002871 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 272944002872 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 272944002873 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 272944002874 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 272944002875 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272944002876 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 272944002877 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272944002878 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 272944002879 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13541 272944002880 Walker A/P-loop; other site 272944002881 ATP binding site [chemical binding]; other site 272944002882 Q-loop/lid; other site 272944002883 ABC transporter signature motif; other site 272944002884 Walker B; other site 272944002885 D-loop; other site 272944002886 H-loop/switch region; other site 272944002887 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 272944002888 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 272944002889 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 272944002890 NADH dehydrogenase subunit G; Validated; Region: PRK09130 272944002891 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272944002892 catalytic loop [active] 272944002893 iron binding site [ion binding]; other site 272944002894 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 272944002895 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 272944002896 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 272944002897 Predicted membrane protein [Function unknown]; Region: COG3671 272944002898 aconitate hydratase; Validated; Region: PRK09277 272944002899 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 272944002900 substrate binding site [chemical binding]; other site 272944002901 ligand binding site [chemical binding]; other site 272944002902 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 272944002903 substrate binding site [chemical binding]; other site 272944002904 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK01474 272944002905 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272944002906 gamma subunit interface [polypeptide binding]; other site 272944002907 epsilon subunit interface [polypeptide binding]; other site 272944002908 LBP interface [polypeptide binding]; other site 272944002909 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272944002910 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272944002911 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272944002912 alpha subunit interaction interface [polypeptide binding]; other site 272944002913 Walker A motif; other site 272944002914 ATP binding site [chemical binding]; other site 272944002915 Walker B motif; other site 272944002916 inhibitor binding site; inhibition site 272944002917 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272944002918 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272944002919 core domain interface [polypeptide binding]; other site 272944002920 delta subunit interface [polypeptide binding]; other site 272944002921 epsilon subunit interface [polypeptide binding]; other site 272944002922 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272944002923 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272944002924 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272944002925 beta subunit interaction interface [polypeptide binding]; other site 272944002926 Walker A motif; other site 272944002927 ATP binding site [chemical binding]; other site 272944002928 Walker B motif; other site 272944002929 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272944002930 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 272944002931 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 272944002932 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272944002933 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272944002934 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272944002935 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 272944002936 dinuclear metal binding motif [ion binding]; other site 272944002937 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 272944002938 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 272944002939 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 272944002940 Transglycosylase; Region: Transgly; pfam00912 272944002941 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272944002942 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 272944002943 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272944002944 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272944002945 FeS/SAM binding site; other site 272944002946 TRAM domain; Region: TRAM; pfam01938 272944002947 HEPN domain; Region: HEPN; cl00824 272944002948 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 272944002949 metal binding triad [ion binding]; metal-binding site 272944002950 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 272944002951 Rickettsial palindromic element RPE1 domain; Region: RPE1; TIGR01045 272944002952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 272944002953 Bacterial SH3 domain; Region: SH3_4; pfam06347 272944002954 Bacterial SH3 domain; Region: SH3_4; pfam06347 272944002955 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 272944002956 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272944002957 TrkA-N domain; Region: TrkA_N; pfam02254 272944002958 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 272944002959 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 272944002960 Autotransporter beta-domain; Region: Autotransporter; smart00869 272944002961 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272944002962 rRNA binding site [nucleotide binding]; other site 272944002963 predicted 30S ribosome binding site; other site 272944002964 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 272944002965 active site 272944002966 dimer interface [polypeptide binding]; other site 272944002967 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 272944002968 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 272944002969 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272944002970 active site 272944002971 DNA binding site [nucleotide binding] 272944002972 Int/Topo IB signature motif; other site 272944002973 Phasin protein; Region: Phasin_2; pfam09361 272944002974 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 272944002975 PLD-like domain; Region: PLDc_2; pfam13091 272944002976 putative active site [active] 272944002977 catalytic site [active] 272944002978 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 272944002979 SurA N-terminal domain; Region: SurA_N_3; cl07813 272944002980 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 272944002981 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 272944002982 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 272944002983 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 272944002984 Autotransporter beta-domain; Region: Autotransporter; pfam03797 272944002985 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272944002986 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 272944002987 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272944002988 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272944002989 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272944002990 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272944002991 active site 272944002992 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 272944002993 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 272944002994 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 272944002995 MPN+ (JAMM) motif; other site 272944002996 Zinc-binding site [ion binding]; other site 272944002997 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 272944002998 Mg++ binding site [ion binding]; other site 272944002999 putative catalytic motif [active] 272944003000 putative substrate binding site [chemical binding]; other site 272944003001 Protein of unknown function (DUF721); Region: DUF721; pfam05258 272944003002 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 272944003003 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 272944003004 Ferredoxin [Energy production and conversion]; Region: COG1146 272944003005 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272944003006 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 272944003007 heme exporter protein CcmC; Region: ccmC; TIGR01191 272944003008 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272944003009 nucleoside/Zn binding site; other site 272944003010 dimer interface [polypeptide binding]; other site 272944003011 catalytic motif [active] 272944003012 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272944003013 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 272944003014 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 272944003015 substrate binding site [chemical binding]; other site 272944003016 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272944003017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272944003018 Walker A/P-loop; other site 272944003019 ATP binding site [chemical binding]; other site 272944003020 Q-loop/lid; other site 272944003021 ABC transporter signature motif; other site 272944003022 Walker B; other site 272944003023 D-loop; other site 272944003024 H-loop/switch region; other site 272944003025 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272944003026 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272944003027 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272944003028 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272944003029 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272944003030 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272944003031 dimer interface [polypeptide binding]; other site 272944003032 ssDNA binding site [nucleotide binding]; other site 272944003033 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272944003034 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 272944003035 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 272944003036 hypothetical protein; Reviewed; Region: PRK01530 272944003037 heat shock protein 90; Provisional; Region: PRK05218 272944003038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272944003039 ATP binding site [chemical binding]; other site 272944003040 Mg2+ binding site [ion binding]; other site 272944003041 G-X-G motif; other site 272944003042 Hsp90 protein; Region: HSP90; pfam00183 272944003043 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 272944003044 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 272944003045 substrate-cofactor binding pocket; other site 272944003046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272944003047 catalytic residue [active] 272944003048 trigger factor; Provisional; Region: tig; PRK01490 272944003049 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 272944003050 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272944003051 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272944003052 GTPase CgtA; Reviewed; Region: obgE; PRK12299 272944003053 GTP1/OBG; Region: GTP1_OBG; pfam01018 272944003054 Obg GTPase; Region: Obg; cd01898 272944003055 G1 box; other site 272944003056 GTP/Mg2+ binding site [chemical binding]; other site 272944003057 Switch I region; other site 272944003058 G2 box; other site 272944003059 G3 box; other site 272944003060 Switch II region; other site 272944003061 G4 box; other site 272944003062 G5 box; other site 272944003063 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 272944003064 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 272944003065 dimer interface [polypeptide binding]; other site 272944003066 active site 272944003067 citrylCoA binding site [chemical binding]; other site 272944003068 NADH binding [chemical binding]; other site 272944003069 cationic pore residues; other site 272944003070 oxalacetate/citrate binding site [chemical binding]; other site 272944003071 coenzyme A binding site [chemical binding]; other site 272944003072 catalytic triad [active] 272944003073 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 272944003074 Fe-S cluster binding site [ion binding]; other site 272944003075 active site 272944003076 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272944003077 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272944003078 RNA binding surface [nucleotide binding]; other site 272944003079 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272944003080 active site 272944003081 bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed; Region: PRK01544 272944003082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272944003083 S-adenosylmethionine binding site [chemical binding]; other site 272944003084 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 272944003085 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 272944003086 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 272944003087 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 272944003088 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 272944003089 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272944003090 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 272944003091 motif 1; other site 272944003092 dimer interface [polypeptide binding]; other site 272944003093 active site 272944003094 motif 2; other site 272944003095 motif 3; other site 272944003096 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272944003097 oligomeric interface; other site 272944003098 putative active site [active] 272944003099 homodimer interface [polypeptide binding]; other site 272944003100 prevent-host-death family protein; Region: phd_fam; TIGR01552 272944003101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 272944003102 metabolite-proton symporter; Region: 2A0106; TIGR00883 272944003103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272944003104 metabolite-proton symporter; Region: 2A0106; TIGR00883 272944003105 ADP-specific Phosphofructokinase/Glucokinase conserved region; Region: ADP_PFK_GK; cl14060 272944003106 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272944003107 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272944003108 motif 1; other site 272944003109 active site 272944003110 motif 2; other site 272944003111 motif 3; other site 272944003112 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272944003113 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272944003114 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272944003115 dimerization interface 3.5A [polypeptide binding]; other site 272944003116 active site 272944003117 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 272944003118 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 272944003119 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272944003120 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 272944003121 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272944003122 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272944003123 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272944003124 DNA binding residues [nucleotide binding] 272944003125 DNA primase, catalytic core; Region: dnaG; TIGR01391 272944003126 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272944003127 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272944003128 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272944003129 active site 272944003130 metal binding site [ion binding]; metal-binding site 272944003131 interdomain interaction site; other site 272944003132 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 272944003133 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272944003134 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272944003135 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272944003136 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 272944003137 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 272944003138 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 272944003139 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 272944003140 ligand binding site [chemical binding]; other site 272944003141 homodimer interface [polypeptide binding]; other site 272944003142 NAD(P) binding site [chemical binding]; other site 272944003143 trimer interface B [polypeptide binding]; other site 272944003144 trimer interface A [polypeptide binding]; other site 272944003145 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 272944003146 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06645 272944003147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272944003148 Walker A motif; other site 272944003149 ATP binding site [chemical binding]; other site 272944003150 Walker B motif; other site 272944003151 arginine finger; other site 272944003152 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272944003153 hypothetical protein; Validated; Region: PRK00153 272944003154 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 272944003155 catalytic motif [active] 272944003156 Catalytic residue [active] 272944003157 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272944003158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272944003159 Walker A/P-loop; other site 272944003160 ATP binding site [chemical binding]; other site 272944003161 Q-loop/lid; other site 272944003162 ABC transporter signature motif; other site 272944003163 Walker B; other site 272944003164 D-loop; other site 272944003165 H-loop/switch region; other site 272944003166 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272944003167 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272944003168 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 272944003169 active site 272944003170 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 272944003171 Predicted permeases [General function prediction only]; Region: COG0795 272944003172 DNA polymerase III subunit chi; Provisional; Region: PRK06646 272944003173 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 272944003174 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 272944003175 metal binding site [ion binding]; metal-binding site 272944003176 dimer interface [polypeptide binding]; other site 272944003177 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272944003178 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272944003179 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 272944003180 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 272944003181 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 272944003182 Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004 272944003183 Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004 272944003184 Uncharacterized conserved protein [Function unknown]; Region: COG1434 272944003185 putative active site [active] 272944003186 lipoate-protein ligase B; Provisional; Region: PRK14347 272944003187 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 272944003188 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 272944003189 amidase catalytic site [active] 272944003190 Zn binding residues [ion binding]; other site 272944003191 substrate binding site [chemical binding]; other site 272944003192 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 272944003193 ribosomal protein L33, bacterial type; Region: rpmG_bact; TIGR01023 272944003194 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 272944003195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272944003196 ATP binding site [chemical binding]; other site 272944003197 Mg2+ binding site [ion binding]; other site 272944003198 G-X-G motif; other site 272944003199 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 272944003200 ATP binding site [chemical binding]; other site 272944003201 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 272944003202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 272944003203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272944003204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272944003205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272944003206 TPR motif; other site 272944003207 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272944003208 binding surface 272944003209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272944003210 TPR motif; other site 272944003211 binding surface 272944003212 TPR repeat; Region: TPR_11; pfam13414 272944003213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272944003214 metabolite-proton symporter; Region: 2A0106; TIGR00883 272944003215 putative substrate translocation pore; other site 272944003216 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 272944003217 BRO family, N-terminal domain; Region: Bro-N; cl10591 272944003218 TIGR00701 family protein; Region: TIGR00701 272944003219 ferrochelatase; Reviewed; Region: hemH; PRK00035 272944003220 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 272944003221 C-terminal domain interface [polypeptide binding]; other site 272944003222 active site 272944003223 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 272944003224 active site 272944003225 N-terminal domain interface [polypeptide binding]; other site 272944003226 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 272944003227 substrate binding site [chemical binding]; other site 272944003228 active site