-- dump date 20140620_034550 -- class Genbank::CDS -- table cds_note -- id note YP_001494105.1 COG1806 Uncharacterized protein conserved in bacteria YP_001494106.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_001494107.1 COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component YP_001494108.1 COG1682 ABC-type polysaccharide/polyol phosphate export systems, permease component YP_001494109.1 undetermined function YP_001494110.1 COG2337 Growth inhibitor YP_001494111.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_001494112.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001494113.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_001494115.1 COG1752 Predicted esterase of the alpha-beta hydrolase superfamily YP_001494116.1 COG1752 Predicted esterase of the alpha-beta hydrolase superfamily YP_001494117.1 COG1196 Chromosome segregation ATPases YP_001494120.1 COG0042 tRNA-dihydrouridine synthase YP_001494123.1 COG0802 Predicted ATPase or kinase YP_001494124.1 COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin YP_001494125.1 COG0617 tRNA nucleotidyltransferase/poly(A) polymerase YP_001494127.1 COG0658 Predicted membrane metal-binding protein YP_001494133.1 COG0740 Protease subunit of ATP-dependent Clp proteases YP_001494135.1 COG0457 FOG: TPR repeat YP_001494136.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_001494137.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B' is part of the membrane proton channel. YP_001494138.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001494139.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001494140.1 COG5336 Uncharacterized protein conserved in bacteria YP_001494141.1 COG1651 Protein-disulfide isomerase YP_001494142.1 COG1329 Transcriptional regulators, similar to M. xanthus CarD YP_001494143.1 COG0500 SAM-dependent methyltransferases YP_001494145.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001494146.1 COG5424 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C YP_001494147.1 COG0262 Dihydrofolate reductase YP_001494149.1 COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase YP_001494157.1 COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems YP_001494158.1 COG1678 Putative transcriptional regulator YP_001494159.1 COG1286 Uncharacterized membrane protein, required for colicin V production YP_001494172.1 COG0542 ATPases with chaperone activity, ATP-binding subunit YP_001494174.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001494175.1 COG1398 Fatty-acid desaturase YP_001494176.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_001494177.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001494178.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001494179.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001494180.1 COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_001494181.1 COG0465 ATP-dependent Zn proteases YP_001494182.1 COG0270 Site-specific DNA methylase YP_001494183.1 COG0270 Site-specific DNA methylase YP_001494184.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_001494187.1 COG1565 Uncharacterized conserved protein YP_001494188.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001494190.1 COG0668 Small-conductance mechanosensitive channel YP_001494191.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_001494192.1 COG0558 Phosphatidylglycerophosphate synthase YP_001494196.1 COG0242 N-formylmethionyl-tRNA deformylase YP_001494197.1 COG3202 ATP/ADP translocase YP_001494198.1 COG2271 Sugar phosphate permease YP_001494199.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001494200.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001494201.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001494202.1 COG1192 ATPases involved in chromosome partitioning YP_001494203.1 COG1475 Predicted transcriptional regulators YP_001494204.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001494206.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_001494209.1 COG0316 Uncharacterized conserved protein YP_001494210.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_001494211.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001494213.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001494216.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_001494217.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_001494218.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_001494219.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_001494220.1 COG3820 Uncharacterized protein conserved in bacteria YP_001494221.1 COG1282 NAD/NADP transhydrogenase beta subunit YP_001494222.1 COG3047 Outer membrane protein W YP_001494223.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_001494224.1 COG0477 Permeases of the major facilitator superfamily YP_001494228.1 COG0143 Methionyl-tRNA synthetase YP_001494229.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001494230.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001494231.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001494234.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_001494235.1 COG2121 Uncharacterized protein conserved in bacteria YP_001494236.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_001494237.1 COG2161 Antitoxin of toxin-antitoxin stability system YP_001494238.1 COG0457 FOG: TPR repeat YP_001494239.1 COG2853 Surface lipoprotein YP_001494240.1 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component YP_001494241.1 COG0462 Phosphoribosylpyrophosphate synthetase YP_001494242.1 COG0462 Phosphoribosylpyrophosphate synthetase YP_001494244.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_001494245.1 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component YP_001494246.1 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component YP_001494250.1 COG0457 FOG: TPR repeat YP_001494252.1 required for 70S ribosome assembly YP_001494253.1 RpmE; RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001494254.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001494255.1 COG0548 Acetylglutamate kinase YP_001494256.1 COG3702 Type IV secretory pathway, VirB3 components YP_001494257.1 COG3451 Type IV secretory pathway, VirB4 components YP_001494258.1 COG3704 Type IV secretory pathway, VirB6 components YP_001494259.1 COG3704 Type IV secretory pathway, VirB6 components YP_001494260.1 COG3704 Type IV secretory pathway, VirB6 components YP_001494261.1 COG3704 Type IV secretory pathway, VirB6 components YP_001494262.1 COG3704 Type IV secretory pathway, VirB6 components YP_001494265.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001494266.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001494267.1 COG3750 Uncharacterized protein conserved in bacteria YP_001494268.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001494269.1 part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_001494270.1 COG0681 Signal peptidase I YP_001494271.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_001494272.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001494273.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001494274.1 COG0565 rRNA methylase YP_001494277.1 COG3660 Predicted nucleoside-diphosphate-sugar epimerase YP_001494278.1 COG0489 ATPases involved in chromosome partitioning YP_001494279.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs YP_001494280.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs YP_001494281.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_001494282.1 COG1054 Predicted sulfurtransferase YP_001494283.1 COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit YP_001494285.1 COG2142 Succinate dehydrogenase, hydrophobic anchor subunit YP_001494286.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001494287.1 COG0765 ABC-type amino acid transport system, permease component YP_001494288.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001494289.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001494290.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001494291.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001494292.1 Modulates Rho-dependent transcription termination YP_001494293.1 binds directly to 23S ribosomal RNA YP_001494294.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001494295.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001494296.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001494297.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001494298.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001494300.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001494301.1 COG1192 ATPases involved in chromosome partitioning YP_001494303.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001494305.1 COG0670 Integral membrane protein, interacts with FtsH YP_001494306.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001494307.1 COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family YP_001494308.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_001494309.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001494310.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001494311.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_001494313.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001494314.1 Catalyzes the phosphorylation of UMP to UDP YP_001494315.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001494316.1 COG0477 Permeases of the major facilitator superfamily YP_001494317.1 COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes YP_001494320.1 COG4775 Outer membrane protein/protective antigen OMA87 YP_001494321.1 COG0750 Predicted membrane-associated Zn-dependent proteases 1 YP_001494322.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001494323.1 COG0293 23S rRNA methylase YP_001494326.1 COG2867 Oligoketide cyclase/lipid transport protein YP_001494327.1 COG5508 Uncharacterized conserved small protein YP_001494328.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001494329.1 COG2155 Uncharacterized conserved protein YP_001494330.1 COG0841 Cation/multidrug efflux pump YP_001494331.1 COG0776 Bacterial nucleoid DNA-binding protein YP_001494332.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001494333.1 COG0541 Signal recognition particle GTPase YP_001494334.1 COG1505 Serine proteases of the peptidase family S9A YP_001494335.1 COG1505 Serine proteases of the peptidase family S9A YP_001494336.1 COG1505 Serine proteases of the peptidase family S9A YP_001494337.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001494339.1 COG0666 FOG: Ankyrin repeat YP_001494343.1 COG1301 Na+/H+-dicarboxylate symporters YP_001494344.1 COG1324 Uncharacterized protein involved in tolerance to divalent cations YP_001494345.1 COG0720 6-pyruvoyl-tetrahydropterin synthase YP_001494346.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_001494348.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001494349.1 COG2317 Zn-dependent carboxypeptidase YP_001494350.1 COG0497 ATPase involved in DNA repair YP_001494351.1 COG4105 DNA uptake lipoprotein YP_001494353.1 COG4572 Putative cation transport regulator YP_001494354.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001494355.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001494356.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_001494357.1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component YP_001494360.1 required for the assembly and function of the DNAX complex which are required for the assembly of the beta subunit onto primed DNA YP_001494361.1 COG2941 Ubiquinone biosynthesis protein COQ7 YP_001494363.1 COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3 YP_001494366.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_001494377.1 COG0451 Nucleoside-diphosphate-sugar epimerases YP_001494378.1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins YP_001494379.1 COG2358 TRAP-type uncharacterized transport system, periplasmic component YP_001494381.1 COG0633 Ferredoxin YP_001494382.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_001494383.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_001494384.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001494386.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001494387.1 COG0695 Glutaredoxin and related proteins YP_001494388.1 COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components YP_001494391.1 negatively supercoils closed circular double-stranded DNA YP_001494397.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001494398.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_001494399.1 COG0147 Anthranilate/para-aminobenzoate synthases component I YP_001494400.1 COG4421 Capsular polysaccharide biosynthesis protein YP_001494401.1 COG1485 Predicted ATPase YP_001494402.1 COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) YP_001494403.1 COG0666 FOG: Ankyrin repeat YP_001494406.1 COG1132 ABC-type multidrug transport system, ATPase and permease components YP_001494408.1 COG1271 Cytochrome bd-type quinol oxidase, subunit 1 YP_001494409.1 COG1294 Cytochrome bd-type quinol oxidase, subunit 2 YP_001494410.1 COG2161 Antitoxin of toxin-antitoxin stability system YP_001494411.1 COG4115 Uncharacterized protein conserved in bacteria YP_001494412.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_001494413.1 COG0612 Predicted Zn-dependent peptidases YP_001494414.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001494415.1 COG0120 Ribose 5-phosphate isomerase YP_001494416.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_001494418.1 COG1132 ABC-type multidrug transport system, ATPase and permease components YP_001494423.1 COG1538 Outer membrane protein YP_001494424.1 COG3827 Uncharacterized protein conserved in bacteria YP_001494426.1 COG0666 FOG: Ankyrin repeat YP_001494427.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001494428.1 COG0793 Periplasmic protease YP_001494429.1 COG0642 Signal transduction histidine kinase YP_001494430.1 COG1729 Uncharacterized protein conserved in bacteria YP_001494432.1 COG1520 FOG: WD40-like repeat YP_001494433.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001494434.1 forms a direct contact with the tRNA during translation YP_001494435.1 COG2173 D-alanyl-D-alanine dipeptidase YP_001494436.1 COG2173 D-alanyl-D-alanine dipeptidase YP_001494440.1 hydrolyzes diadenosine polyphosphate YP_001494441.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001494442.1 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family YP_001494444.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine YP_001494445.1 COG1183 Phosphatidylserine synthase YP_001494446.1 COG1566 Multidrug resistance efflux pump YP_001494450.1 COG0271 Stress-induced morphogen (activity unknown) YP_001494451.1 COG2200 FOG: EAL domain YP_001494452.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001494453.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001494454.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001494455.1 COG1589 Cell division septal protein YP_001494456.1 COG0849 Actin-like ATPase involved in cell division YP_001494458.1 COG3474 Cytochrome c2 YP_001494460.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_001494462.1 COG1530 Ribonucleases G and E YP_001494463.1 COG1612 Uncharacterized protein required for cytochrome oxidase assembly YP_001494464.1 COG0564 Pseudouridylate synthases, 23S RNA-specific YP_001494465.1 COG0708 Exonuclease III YP_001494466.1 COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit YP_001494467.1 catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acyltransferase within the complex. The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2); it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase YP_001494468.1 COG1217 Predicted membrane GTPase involved in stress response YP_001494472.1 COG2825 Outer membrane protein YP_001494473.1 catalyzes the formation of 2-oxoglutarate from isocitrate YP_001494474.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_001494475.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001494478.1 COG0723 Rieske Fe-S protein YP_001494479.1 COG1290 Cytochrome b subunit of the bc complex YP_001494481.1 COG2857 Cytochrome c1 YP_001494482.1 COG3067 Na+/H+ antiporter YP_001494483.1 COG0071 Molecular chaperone (small heat shock protein) YP_001494486.1 COG4804 Uncharacterized conserved protein YP_001494487.1 COG4804 Uncharacterized conserved protein YP_001494488.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_001494489.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001494493.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_001494494.1 COG0477 Permeases of the major facilitator superfamily YP_001494495.1 COG0772 Bacterial cell division membrane protein YP_001494496.1 COG1770 Protease II YP_001494497.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_001494499.1 COG1487 Predicted nucleic acid-binding protein, contains PIN domain YP_001494501.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_001494502.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_001494503.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001494504.1 COG3504 Type IV secretory pathway, VirB9 components YP_001494505.1 COG3736 Type IV secretory pathway, component VirB8 YP_001494507.1 COG3736 Type IV secretory pathway, component VirB8 YP_001494508.1 COG3504 Type IV secretory pathway, VirB9 components YP_001494509.1 COG2948 Type IV secretory pathway, VirB10 components YP_001494510.1 COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis YP_001494511.1 COG3505 Type IV secretory pathway, VirD4 components YP_001494512.1 COG0248 Exopolyphosphatase YP_001494518.1 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase YP_001494519.1 This protein performs the mismatch recognition step during the DNA repair process YP_001494520.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_001494521.1 COG0739 Membrane proteins related to metalloendopeptidases YP_001494522.1 COG1451 Predicted metal-dependent hydrolase YP_001494523.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor YP_001494524.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_001494525.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_001494526.1 involved in the insertion of copper into subunit I of cytochrome C oxidase YP_001494527.1 COG0457 FOG: TPR repeat YP_001494528.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001494530.1 COG0531 Amino acid transporters YP_001494531.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001494532.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains YP_001494533.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains YP_001494539.1 COG0811 Biopolymer transport proteins YP_001494540.1 COG0848 Biopolymer transport protein YP_001494543.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_001494544.1 COG0477 Permeases of the major facilitator superfamily YP_001494545.1 COG0845 Membrane-fusion protein YP_001494546.1 COG4618 ABC-type protease/lipase transport system, ATPase and permease components YP_001494547.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001494548.1 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases YP_001494550.1 heat shock protein involved in degradation of misfolded proteins YP_001494551.1 heat shock protein involved in degradation of misfolded proteins YP_001494554.1 COG5464 Uncharacterized conserved protein YP_001494555.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_001494557.1 COG1559 Predicted periplasmic solute-binding protein YP_001494558.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_001494562.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001494563.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001494564.1 COG0450 Peroxiredoxin YP_001494565.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs YP_001494566.1 COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases YP_001494567.1 COG2194 Predicted membrane-associated, metal-dependent hydrolase YP_001494568.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001494569.1 COG3093 Plasmid maintenance system antidote protein YP_001494571.1 COG1091 dTDP-4-dehydrorhamnose reductase YP_001494572.1 COG1086 Predicted nucleoside-diphosphate sugar epimerases YP_001494573.1 COG0381 UDP-N-acetylglucosamine 2-epimerase YP_001494575.1 COG0500 SAM-dependent methyltransferases YP_001494576.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_001494577.1 COG0845 Membrane-fusion protein YP_001494579.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_001494580.1 COG0438 Glycosyltransferase YP_001494583.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001494584.1 converts protoheme IX and farnesyl diphosphate to heme O YP_001494585.1 COG1533 DNA repair photolyase YP_001494587.1 COG0457 FOG: TPR repeat YP_001494588.1 COG2982 Uncharacterized protein involved in outer membrane biogenesis YP_001494589.1 Essential for efficient processing of 16S rRNA YP_001494591.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_001494592.1 COG5304 Uncharacterized protein conserved in bacteria YP_001494593.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair YP_001494594.1 COG2350 Uncharacterized protein conserved in bacteria YP_001494596.1 COG0759 Uncharacterized conserved protein YP_001494597.1 Catalyzes the transfer of electrons from NADH to quinone YP_001494598.1 Catalyzes the transfer of electrons from NADH to quinone YP_001494599.1 Catalyzes the transfer of electrons from NADH to quinone YP_001494600.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_001494601.1 Catalyzes the transfer of electrons from NADH to quinone YP_001494602.1 COG3307 Lipid A core - O-antigen ligase and related enzymes YP_001494603.1 COG4765 Uncharacterized protein conserved in bacteria YP_001494604.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001494607.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001494608.1 Transfers the fatty acyl group on membrane lipoproteins YP_001494610.1 COG3023 Negative regulator of beta-lactamase expression YP_001494611.1 COG2984 ABC-type uncharacterized transport system, periplasmic component YP_001494612.1 COG4120 ABC-type uncharacterized transport system, permease component YP_001494613.1 COG1101 ABC-type uncharacterized transport system, ATPase component YP_001494615.1 COG0666 FOG: Ankyrin repeat YP_001494619.1 COG1495 Disulfide bond formation protein DsbB YP_001494620.1 class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine YP_001494621.1 COG0679 Predicted permeases YP_001494622.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_001494625.1 COG4374 Uncharacterized protein conserved in bacteria YP_001494626.1 COG2002 Regulators of stationary/sporulation gene expression YP_001494627.1 COG0477 Permeases of the major facilitator superfamily YP_001494631.1 COG0541 Signal recognition particle GTPase YP_001494635.1 Catalyzes the reversible oxidation of malate to oxaloacetate YP_001494636.1 COG0666 FOG: Ankyrin repeat YP_001494637.1 COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit YP_001494638.1 COG3202 ATP/ADP translocase YP_001494639.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001494640.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_001494643.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001494644.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001494645.1 COG3177 Uncharacterized conserved protein YP_001494647.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001494650.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001494651.1 COG1132 ABC-type multidrug transport system, ATPase and permease components YP_001494652.1 COG0477 Permeases of the major facilitator superfamily YP_001494653.1 COG1686 D-alanyl-D-alanine carboxypeptidase YP_001494654.1 COG0797 Lipoproteins YP_001494655.1 COG2823 Predicted periplasmic or secreted lipoprotein YP_001494657.1 Involved in cell division; probably involved in intracellular septation YP_001494658.1 COG0672 High-affinity Fe2+/Pb2+ permease YP_001494660.1 COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1 YP_001494661.1 COG3485 Protocatechuate 3,4-dioxygenase beta subunit YP_001494662.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_001494663.1 COG0616 Periplasmic serine proteases (ClpP class) YP_001494664.1 catalyzes the formation of dUMP from dUTP YP_001494665.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_001494667.1 COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF YP_001494668.1 COG2887 RecB family exonuclease YP_001494670.1 COG2071 Predicted glutamine amidotransferases YP_001494671.1 COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1 YP_001494672.1 COG0110 Acetyltransferase (isoleucine patch superfamily) YP_001494673.1 COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2 YP_001494674.1 COG0739 Membrane proteins related to metalloendopeptidases YP_001494675.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001494677.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001494678.1 COG0772 Bacterial cell division membrane protein YP_001494679.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001494685.1 COG0841 Cation/multidrug efflux pump YP_001494686.1 COG0841 Cation/multidrug efflux pump YP_001494687.1 COG0841 Cation/multidrug efflux pump YP_001494688.1 COG0841 Cation/multidrug efflux pump YP_001494689.1 COG0841 Cation/multidrug efflux pump YP_001494691.1 COG0438 Glycosyltransferase YP_001494693.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001494694.1 COG0621 2-methylthioadenine synthetase YP_001494695.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001494696.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001494697.1 binds the polymerase to DNA and acts as a sliding clamp YP_001494699.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001494701.1 COG0349 Ribonuclease D YP_001494702.1 COG2919 Septum formation initiator YP_001494703.1 COG0575 CDP-diglyceride synthetase YP_001494704.1 COG0020 Undecaprenyl pyrophosphate synthase YP_001494705.1 COG0642 Signal transduction histidine kinase YP_001494706.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_001494707.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001494708.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001494709.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001494710.1 COG1651 Protein-disulfide isomerase YP_001494711.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_001494712.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001494714.1 COG5611 Predicted nucleic-acid-binding protein, contains PIN domain YP_001494715.1 COG2002 Regulators of stationary/sporulation gene expression YP_001494718.1 COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases YP_001494719.1 COG4395 Uncharacterized protein conserved in bacteria YP_001494720.1 COG1835 Predicted acyltransferases YP_001494721.1 COG1835 Predicted acyltransferases YP_001494722.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001494723.1 COG1238 Predicted membrane protein YP_001494724.1 COG1714 Predicted membrane protein/domain YP_001494725.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001494731.1 catalyzes the phosphorylation of NAD to NADP YP_001494732.1 COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily YP_001494733.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001494734.1 COG0679 Predicted permeases YP_001494735.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_001494736.1 COG0492 Thioredoxin reductase YP_001494737.1 COG1012 NAD-dependent aldehyde dehydrogenases YP_001494740.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_001494741.1 COG0210 Superfamily I DNA and RNA helicases YP_001494746.1 catalyzes the formation of 2-oxobutanoate from L-threonine YP_001494747.1 COG0466 ATP-dependent Lon protease, bacterial type YP_001494753.1 COG1544 Ribosome-associated protein Y (PSrp-1) YP_001494754.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001494755.1 COG0492 Thioredoxin reductase YP_001494756.1 COG3121 P pilus assembly protein, chaperone PapD YP_001494757.1 COG0045 Succinyl-CoA synthetase, beta subunit YP_001494759.1 COG3188 P pilus assembly protein, porin PapC YP_001494760.1 COG5430 Uncharacterized secreted protein YP_001494763.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001494766.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_001494770.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001494772.1 COG1109 Phosphomannomutase YP_001494774.1 COG1137 ABC-type (unclassified) transport system, ATPase component YP_001494775.1 COG1934 Uncharacterized protein conserved in bacteria YP_001494776.1 COG5375 Uncharacterized protein conserved in bacteria YP_001494777.1 COG0794 Predicted sugar phosphate isomerase involved in capsule formation YP_001494779.1 COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) YP_001494780.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001494781.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; proteins in this cluster have Rickettsial repeat elements (RPE) inserts YP_001494782.1 COG3202 ATP/ADP translocase YP_001494783.1 COG0460 Homoserine dehydrogenase YP_001494784.1 COG1396 Predicted transcriptional regulators YP_001494785.1 COG1295 Predicted membrane protein YP_001494786.1 COG0174 Glutamine synthetase YP_001494787.1 COG1496 Uncharacterized conserved protein YP_001494788.1 COG0242 N-formylmethionyl-tRNA deformylase YP_001494790.1 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases YP_001494793.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001494794.1 COG0625 Glutathione S-transferase YP_001494795.1 COG4285 Uncharacterized conserved protein YP_001494797.1 COG1268 Uncharacterized conserved protein YP_001494798.1 COG0285 Folylpolyglutamate synthase YP_001494799.1 COG0605 Superoxide dismutase YP_001494801.1 COG0340 Biotin-(acetyl-CoA carboxylase) ligase YP_001494803.1 COG5448 Uncharacterized conserved protein YP_001494805.1 COG5449 Uncharacterized conserved protein YP_001494807.1 COG5346 Predicted membrane protein YP_001494808.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_001494809.1 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes YP_001494810.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001494811.1 COG0608 Single-stranded DNA-specific exonuclease YP_001494812.1 COG0500 SAM-dependent methyltransferases YP_001494813.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001494814.1 COG0616 Periplasmic serine proteases (ClpP class) YP_001494815.1 COG0776 Bacterial nucleoid DNA-binding protein YP_001494819.1 COG3022 Uncharacterized protein conserved in bacteria YP_001494824.1 COG1373 Predicted ATPase (AAA+ superfamily) YP_001494826.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001494827.1 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_001494828.1 COG5622 Protein required for attachment to host cells YP_001494830.1 COG2945 Predicted hydrolase of the alpha/beta superfamily YP_001494831.1 COG2956 Predicted N-acetylglucosaminyl transferase YP_001494834.1 COG1279 Lysine efflux permease YP_001494836.1 COG0477 Permeases of the major facilitator superfamily YP_001494840.1 COG3202 ATP/ADP translocase YP_001494842.1 COG0142 Geranylgeranyl pyrophosphate synthase YP_001494843.1 COG0006 Xaa-Pro aminopeptidase YP_001494844.1 COG0531 Amino acid transporters YP_001494845.1 COG0316 Uncharacterized conserved protein YP_001494846.1 COG0822 NifU homolog involved in Fe-S cluster formation YP_001494847.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_001494848.1 COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes YP_001494849.1 COG1959 Predicted transcriptional regulator YP_001494855.1 COG4804 Uncharacterized conserved protein YP_001494856.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases YP_001494857.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate YP_001494858.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001494859.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001494860.1 COG1396 Predicted transcriptional regulators YP_001494866.1 COG1373 Predicted ATPase (AAA+ superfamily) YP_001494869.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_001494870.1 COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF YP_001494871.1 COG0642 Signal transduction histidine kinase YP_001494872.1 COG0642 Signal transduction histidine kinase YP_001494873.1 COG0666 FOG: Ankyrin repeat YP_001494875.1 COG0354 Predicted aminomethyltransferase related to GcvT YP_001494876.1 COG1723 Uncharacterized conserved protein YP_001494877.1 COG0349 Ribonuclease D YP_001494879.1 COG0212 5-formyltetrahydrofolate cyclo-ligase YP_001494880.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001494881.1 COG0500 SAM-dependent methyltransferases YP_001494883.1 COG0338 Site-specific DNA methylase YP_001494887.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_001494891.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif YP_001494892.1 COG0217 Uncharacterized conserved protein YP_001494893.1 COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) YP_001494897.1 COG1694 Predicted pyrophosphatase YP_001494898.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases YP_001494900.1 COG0466 ATP-dependent Lon protease, bacterial type YP_001494906.1 Catalyzes the transfer of electrons from NADH to quinone YP_001494908.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001494912.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_001494913.1 COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase YP_001494915.1 unwinds double stranded DNA YP_001494917.1 COG0814 Amino acid permeases YP_001494918.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_001494919.1 COG1357 Uncharacterized low-complexity proteins YP_001494920.1 COG0742 N6-adenine-specific methylase YP_001494921.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001494922.1 COG0191 Fructose/tagatose bisphosphate aldolase YP_001494923.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_001494925.1 COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone YP_001494927.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001494928.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001494929.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001494932.1 COG1959 Predicted transcriptional regulator YP_001494933.1 COG1189 Predicted rRNA methylase YP_001494934.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001494936.1 COG5304 Uncharacterized protein conserved in bacteria YP_001494939.1 COG3547 Transposase and inactivated derivatives YP_001494940.1 COG0522 Ribosomal protein S4 and related proteins YP_001494944.1 COG2271 Sugar phosphate permease YP_001494949.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone YP_001494950.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001494951.1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains YP_001494952.1 COG1357 Uncharacterized low-complexity proteins YP_001494954.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2 YP_001494957.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2 YP_001494959.1 COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis YP_001494960.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001494962.1 COG0591 Na+/proline symporter YP_001494964.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001494965.1 COG2847 Uncharacterized protein conserved in bacteria YP_001494966.1 COG4912 Predicted DNA alkylation repair enzyme YP_001494967.1 COG0350 Methylated DNA-protein cysteine methyltransferase YP_001494969.1 COG2169 Adenosine deaminase YP_001494970.1 COG2169 Adenosine deaminase YP_001494971.1 COG0350 Methylated DNA-protein cysteine methyltransferase YP_001494978.1 COG0666 FOG: Ankyrin repeat YP_001494979.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001494980.1 COG0760 Parvulin-like peptidyl-prolyl isomerase YP_001494981.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001494982.1 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_001494983.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001494984.1 negatively supercoils closed circular double-stranded DNA YP_001494985.1 COG0647 Predicted sugar phosphatases of the HAD superfamily YP_001494986.1 COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain) YP_001494988.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_001494991.1 COG4710 Predicted DNA-binding protein with an HTH domain YP_001494993.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_001494994.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001494995.1 COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems YP_001494996.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_001494997.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_001494998.1 COG0728 Uncharacterized membrane protein, putative virulence factor YP_001495001.1 COG1200 RecG-like helicase YP_001495002.1 COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit YP_001495003.1 COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit YP_001495004.1 COG0655 Multimeric flavodoxin WrbA YP_001495005.1 COG0655 Multimeric flavodoxin WrbA YP_001495008.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001495009.1 COG0770 UDP-N-acetylmuramyl pentapeptide synthase YP_001495010.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001495011.1 COG1197 Transcription-repair coupling factor (superfamily II helicase) YP_001495012.1 COG2938 Uncharacterized conserved protein YP_001495013.1 COG0607 Rhodanese-related sulfurtransferase YP_001495014.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001495020.1 COG3621 Patatin YP_001495022.1 COG0477 Permeases of the major facilitator superfamily YP_001495025.1 COG1708 Predicted nucleotidyltransferases YP_001495026.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001495027.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001495028.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001495029.1 COG0602 Organic radical activating enzymes YP_001495030.1 COG0291 Ribosomal protein L35 YP_001495031.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001495032.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_001495033.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_001495034.1 COG0666 FOG: Ankyrin repeat YP_001495035.1 COG1471 Ribosomal protein S4E YP_001495038.1 COG0598 Mg2+ and Co2+ transporters YP_001495041.1 COG3173 Predicted aminoglycoside phosphotransferase YP_001495042.1 COG3173 Predicted aminoglycoside phosphotransferase YP_001495043.1 COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation YP_001495045.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001495046.1 COG5590 Uncharacterized conserved protein YP_001495049.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) YP_001495052.1 COG1729 Uncharacterized protein conserved in bacteria YP_001495054.1 COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit YP_001495055.1 COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) YP_001495057.1 Synthesizes thioester adducts of fatty acids enzymatically to the phosphopantetheine group of acyl carrier protein YP_001495059.1 Involved in ubiquinone biosynthesis YP_001495060.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001495061.1 COG5342 Invasion protein B, involved in pathogenesis YP_001495063.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001495064.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001495066.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001495067.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_001495068.1 COG0628 Predicted permease YP_001495069.1 COG0593 ATPase involved in DNA replication initiation YP_001495074.1 COG0477 Permeases of the major facilitator superfamily YP_001495076.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001495077.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001495078.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001495079.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001495080.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001495081.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001495082.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001495083.1 late assembly protein YP_001495084.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001495085.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001495086.1 binds 5S rRNA along with protein L5 and L25 YP_001495087.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001495088.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001495089.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001495090.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001495091.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001495092.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001495093.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001495094.1 one of the stabilizing components for the large ribosomal subunit YP_001495095.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001495096.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001495097.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001495098.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001495099.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001495100.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001495101.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001495102.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001495103.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_001495104.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001495105.1 COG0566 rRNA methylases YP_001495108.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001495109.1 COG4118 Antitoxin of toxin-antitoxin stability system YP_001495111.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001495113.1 COG4574 Serine protease inhibitor ecotin YP_001495114.1 COG0694 Thioredoxin-like proteins and domains YP_001495115.1 COG0477 Permeases of the major facilitator superfamily YP_001495116.1 COG0513 Superfamily II DNA and RNA helicases YP_001495117.1 COG1278 Cold shock proteins YP_001495118.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001495119.1 COG0760 Parvulin-like peptidyl-prolyl isomerase YP_001495120.1 COG1452 Organic solvent tolerance protein OstA YP_001495121.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001495123.1 COG0708 Exonuclease III YP_001495124.1 COG4095 Uncharacterized conserved protein YP_001495126.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001495127.1 COG1373 Predicted ATPase (AAA+ superfamily) YP_001495130.1 COG0661 Predicted unusual protein kinase YP_001495132.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_001495133.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001495134.1 COG0836 Mannose-1-phosphate guanylyltransferase YP_001495138.1 COG2958 Uncharacterized protein conserved in bacteria YP_001495140.1 COG2958 Uncharacterized protein conserved in bacteria YP_001495141.1 COG0084 Mg-dependent DNase YP_001495142.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001495143.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_001495144.1 COG0477 Permeases of the major facilitator superfamily YP_001495145.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin YP_001495147.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001495148.1 COG3475 LPS biosynthesis protein YP_001495149.1 COG3475 LPS biosynthesis protein YP_001495150.1 COG1373 Predicted ATPase (AAA+ superfamily) YP_001495151.1 COG1322 Uncharacterized protein conserved in bacteria YP_001495157.1 binds and unfolds substrates as part of the ClpXP protease YP_001495158.1 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins YP_001495159.1 COG0603 Predicted PP-loop superfamily ATPase YP_001495160.1 COG1598 Uncharacterized conserved protein YP_001495162.1 COG1132 ABC-type multidrug transport system, ATPase and permease components YP_001495164.1 COG0477 Permeases of the major facilitator superfamily YP_001495165.1 COG4591 ABC-type transport system, involved in lipoprotein release, permease component YP_001495166.1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component YP_001495168.1 COG4536 Putative Mg2+ and Co2+ transporter CorB YP_001495169.1 COG1138 Cytochrome c biogenesis factor YP_001495174.1 COG4625 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain YP_001495175.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_001495176.1 COG1472 Beta-glucosidase-related glycosidases YP_001495177.1 COG0789 Predicted transcriptional regulators YP_001495178.1 COG0776 Bacterial nucleoid DNA-binding protein YP_001495179.1 COG0141 Histidinol dehydrogenase YP_001495180.1 COG1225 Peroxiredoxin YP_001495181.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_001495182.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_001495183.1 COG0739 Membrane proteins related to metalloendopeptidases YP_001495184.1 COG2961 Protein involved in catabolism of external DNA YP_001495185.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_001495187.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001495188.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_001495193.1 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component YP_001495194.1 COG3761 NADH:ubiquinone oxidoreductase 17.2 kD subunit YP_001495195.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_001495196.1 COG3814 Uncharacterized protein conserved in bacteria YP_001495197.1 COG3494 Uncharacterized protein conserved in bacteria YP_001495198.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_001495199.1 3'-5' exonuclease of DNA polymerase III YP_001495200.1 COG3346 Uncharacterized conserved protein YP_001495201.1 COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) YP_001495204.1 COG0331 (acyl-carrier-protein) S-malonyltransferase YP_001495213.1 COG3243 Poly(3-hydroxyalkanoate) synthetase YP_001495214.1 COG3202 ATP/ADP translocase YP_001495215.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_001495216.1 COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance YP_001495217.1 COG1253 Hemolysins and related proteins containing CBS domains YP_001495218.1 COG0319 Predicted metal-dependent hydrolase YP_001495221.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001495222.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001495223.1 COG0400 Predicted esterase YP_001495224.1 COG0278 Glutaredoxin-related protein YP_001495225.1 COG0177 Predicted EndoIII-related endonuclease YP_001495231.1 COG5510 Predicted small secreted protein YP_001495235.1 COG0313 Predicted methyltransferases YP_001495236.1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component YP_001495237.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001495238.1 COG1267 Phosphatidylglycerophosphatase A and related proteins YP_001495239.1 COG0261 Ribosomal protein L21 YP_001495240.1 involved in the peptidyltransferase reaction during translation YP_001495241.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_001495242.1 COG1396 Predicted transcriptional regulators YP_001495244.1 COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold YP_001495248.1 COG0477 Permeases of the major facilitator superfamily YP_001495250.1 COG3027 Uncharacterized protein conserved in bacteria YP_001495252.1 COG1426 Uncharacterized protein conserved in bacteria YP_001495253.1 COG2902 NAD-specific glutamate dehydrogenase YP_001495254.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001495259.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001495260.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001495262.1 carries the fatty acid chain in fatty acid biosynthesis YP_001495263.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001495264.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains YP_001495265.1 COG1196 Chromosome segregation ATPases YP_001495267.1 COG1373 Predicted ATPase (AAA+ superfamily) YP_001495268.1 Essential for recycling GMP and indirectly, cGMP YP_001495269.1 COG1396 Predicted transcriptional regulators YP_001495270.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001495271.1 functions in MreBCD complex in some organisms YP_001495272.1 COG0795 Predicted permeases YP_001495273.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_001495275.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001495276.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001495277.1 COG2913 Small protein A (tmRNA-binding) YP_001495278.1 COG0552 Signal recognition particle GTPase YP_001495279.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_001495280.1 COG0192 S-adenosylmethionine synthetase YP_001495285.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_001495286.1 COG1004 Predicted UDP-glucose 6-dehydrogenase YP_001495288.1 COG0477 Permeases of the major facilitator superfamily YP_001495289.1 COG0805 Sec-independent protein secretion pathway component TatC YP_001495290.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001495291.1 COG3451 Type IV secretory pathway, VirB4 components YP_001495293.1 COG0861 Membrane protein TerC, possibly involved in tellurium resistance YP_001495294.1 COG3637 Opacity protein and related surface antigens YP_001495295.1 COG0500 SAM-dependent methyltransferases YP_001495297.1 COG2944 Predicted transcriptional regulator YP_001495298.1 Catalyzes the transfer of electrons from NADH to quinone YP_001495299.1 Catalyzes the transfer of electrons from NADH to quinone YP_001495300.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_001495301.1 Catalyzes the transfer of electrons from NADH to quinone YP_001495302.1 ATP-binding protein; required for proper cytochrome c maturation YP_001495303.1 Catalyzes the transfer of electrons from NADH to quinone YP_001495304.1 Catalyzes the transfer of electrons from NADH to quinone YP_001495305.1 Catalyzes the transfer of electrons from NADH to quinone YP_001495306.1 COG3671 Predicted membrane protein YP_001495307.1 Catalyzes the conversion of citrate to isocitrate YP_001495308.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_001495309.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001495310.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001495311.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001495312.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001495313.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001495314.1 COG0783 DNA-binding ferritin-like protein (oxidative damage protectant) YP_001495318.1 COG2602 Beta-lactamase class D YP_001495319.1 COG2602 Beta-lactamase class D YP_001495320.1 COG5009 Membrane carboxypeptidase/penicillin-binding protein YP_001495321.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001495327.1 COG3807 Uncharacterized protein conserved in bacteria YP_001495328.1 COG0475 Kef-type K+ transport systems, membrane components YP_001495329.1 COG0799 Uncharacterized homolog of plant Iojap protein YP_001495330.1 COG0271 Stress-induced morphogen (activity unknown) YP_001495338.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001495339.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001495340.1 COG1734 DnaK suppressor protein YP_001495341.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001495343.1 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes YP_001495345.1 COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases YP_001495346.1 COG0760 Parvulin-like peptidyl-prolyl isomerase YP_001495348.1 COG1140 Nitrate reductase beta subunit YP_001495351.1 COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins YP_001495352.1 COG1835 Predicted acyltransferases YP_001495353.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_001495354.1 COG2003 DNA repair proteins YP_001495355.1 COG2003 DNA repair proteins YP_001495356.1 COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase YP_001495358.1 COG3637 Opacity protein and related surface antigens YP_001495359.1 COG3637 Opacity protein and related surface antigens YP_001495360.1 COG1146 Ferredoxin YP_001495361.1 COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component YP_001495362.1 COG0590 Cytosine/adenosine deaminases YP_001495363.1 COG0053 Predicted Co/Zn/Cd cation transporters YP_001495364.1 COG4520 Surface antigen YP_001495365.1 COG1881 Phospholipid-binding protein YP_001495366.1 COG1121 ABC-type Mn/Zn transport systems, ATPase component YP_001495372.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001495373.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_001495377.1 COG1872 Uncharacterized conserved protein YP_001495378.1 molecular chaperone YP_001495379.1 catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine YP_001495381.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001495382.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001495383.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_001495384.1 COG3636 Predicted transcriptional regulator YP_001495385.1 COG1573 Uracil-DNA glycosylase YP_001495386.1 COG0564 Pseudouridylate synthases, 23S RNA-specific YP_001495389.1 fusion of hemK/trmB; N-terminal HemK domain transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; C-terminal YP_001495390.1 COG0009 Putative translation factor (SUA5) YP_001495391.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001495392.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001495393.1 COG1487 Predicted nucleic acid-binding protein, contains PIN domain YP_001495395.1 COG1636 Uncharacterized protein conserved in bacteria YP_001495397.1 COG1474 Cdc6-related protein, AAA superfamily ATPase YP_001495399.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001495400.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001495401.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_001495402.1 synthesizes RNA primers at the replication forks YP_001495403.1 COG0170 Dolichol kinase YP_001495404.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001495405.1 COG3288 NAD/NADP transhydrogenase alpha subunit YP_001495406.1 COG3288 NAD/NADP transhydrogenase alpha subunit YP_001495407.1 COG2834 Outer membrane lipoprotein-sorting protein YP_001495408.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; rhe tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_001495409.1 COG0718 Uncharacterized protein conserved in bacteria YP_001495413.1 COG3577 Predicted aspartyl protease YP_001495418.1 COG2161 Antitoxin of toxin-antitoxin stability system YP_001495419.1 COG1126 ABC-type polar amino acid transport system, ATPase component YP_001495420.1 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I YP_001495421.1 COG0671 Membrane-associated phospholipid phosphatase YP_001495422.1 COG3077 DNA-damage-inducible protein J YP_001495423.1 COG3041 Uncharacterized protein conserved in bacteria YP_001495424.1 COG0795 Predicted permeases YP_001495425.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001495427.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001495428.1 COG0732 Restriction endonuclease S subunits YP_001495430.1 COG0286 Type I restriction-modification system methyltransferase subunit YP_001495434.1 COG3004 Na+/H+ antiporter YP_001495436.1 COG1434 Uncharacterized conserved protein YP_001495437.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_001495438.1 COG3023 Negative regulator of beta-lactamase expression YP_001495439.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001495440.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001495441.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001495444.1 COG0457 FOG: TPR repeat YP_001495445.1 COG0477 Permeases of the major facilitator superfamily YP_001495446.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_001495447.1 COG1981 Predicted membrane protein YP_001495448.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_001495449.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III