-- dump date   	20120504_160757
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
693978000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
693978000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
693978000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978000004	Walker A motif; other site
693978000005	ATP binding site [chemical binding]; other site
693978000006	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978000007	Walker B motif; other site
693978000008	arginine finger; other site
693978000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
693978000010	DnaA box-binding interface [nucleotide binding]; other site
693978000011	Low molecular weight phosphatase family; Region: LMWPc; cd00115
693978000012	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
693978000013	active site
693978000014	Predicted methyltransferases [General function prediction only]; Region: COG0313
693978000015	Rrf2 family protein; Region: rrf2_super; TIGR00738
693978000016	Helix-turn-helix domains; Region: HTH; cl00088
693978000017	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
693978000018	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
693978000019	putative DNA binding site [nucleotide binding]; other site
693978000020	putative Zn2+ binding site [ion binding]; other site
693978000021	AsnC family; Region: AsnC_trans_reg; pfam01037
693978000022	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
693978000023	Family of unknown function (DUF490); Region: DUF490; pfam04357
693978000024	UGMP family protein; Validated; Region: PRK09604
693978000025	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
693978000026	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
693978000027	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
693978000028	Bacitracin resistance protein BacA; Region: BacA; cl00858
693978000029	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
693978000030	FtsX-like permease family; Region: FtsX; cl15850
693978000031	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
693978000032	FtsX-like permease family; Region: FtsX; cl15850
693978000033	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
693978000034	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
693978000035	MgtE intracellular N domain; Region: MgtE_N; cl15244
693978000036	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
693978000037	Divalent cation transporter; Region: MgtE; cl00786
693978000038	exodeoxyribonuclease X; Provisional; Region: PRK07983
693978000039	exodeoxyribonuclease X; Provisional; Region: PRK07983
693978000040	Isochorismatase family; Region: Isochorismatase; pfam00857
693978000041	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
693978000042	catalytic triad [active]
693978000043	conserved cis-peptide bond; other site
693978000044	NAD-dependent deacetylase; Provisional; Region: PRK00481
693978000045	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
693978000046	NAD+ binding site [chemical binding]; other site
693978000047	substrate binding site [chemical binding]; other site
693978000048	Zn binding site [ion binding]; other site
693978000049	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
693978000050	Helix-turn-helix domains; Region: HTH; cl00088
693978000051	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
693978000052	FeoA domain; Region: FeoA; cl00838
693978000053	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
693978000054	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
693978000055	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
693978000056	dihydrodipicolinate synthase; Region: dapA; TIGR00674
693978000057	dimer interface [polypeptide binding]; other site
693978000058	active site
693978000059	catalytic residue [active]
693978000060	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693978000061	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978000062	starch binding outer membrane protein SusD; Region: SusD; cd08977
693978000063	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
693978000064	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
693978000065	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
693978000066	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
693978000067	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
693978000068	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
693978000069	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
693978000070	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
693978000071	protein binding site [polypeptide binding]; other site
693978000072	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
693978000073	Domain interface; other site
693978000074	Peptide binding site; other site
693978000075	Active site tetrad [active]
693978000076	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
693978000077	DDE superfamily endonuclease; Region: DDE_4; cl15789
693978000078	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
693978000079	Site-specific recombinase; Region: SpecificRecomb; cl15411
693978000080	Transglycosylase; Region: Transgly; cl07896
693978000081	Predicted phosphohydrolases [General function prediction only]; Region: COG1408
693978000082	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
693978000083	putative active site [active]
693978000084	putative metal binding site [ion binding]; other site
693978000085	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
693978000086	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
693978000087	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
693978000088	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
693978000089	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
693978000090	tetramer interface [polypeptide binding]; other site
693978000091	heme binding pocket [chemical binding]; other site
693978000092	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
693978000093	DDE superfamily endonuclease; Region: DDE_4; cl15789
693978000094	starch binding outer membrane protein SusD; Region: SusD; cl15876
693978000095	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978000096	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978000097	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
693978000098	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693978000099	S-adenosylmethionine binding site [chemical binding]; other site
693978000100	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
693978000101	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
693978000102	dimer interface [polypeptide binding]; other site
693978000103	active site
693978000104	CoA binding pocket [chemical binding]; other site
693978000105	Membrane protein of unknown function; Region: DUF360; cl00850
693978000106	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
693978000107	GTP-binding protein YchF; Reviewed; Region: PRK09601
693978000108	YchF GTPase; Region: YchF; cd01900
693978000109	G1 box; other site
693978000110	GTP/Mg2+ binding site [chemical binding]; other site
693978000111	Switch I region; other site
693978000112	G2 box; other site
693978000113	Switch II region; other site
693978000114	G3 box; other site
693978000115	G4 box; other site
693978000116	G5 box; other site
693978000117	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
693978000118	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
693978000119	active site
693978000120	intersubunit interactions; other site
693978000121	catalytic residue [active]
693978000122	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978000123	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
693978000124	NAD(P) binding site [chemical binding]; other site
693978000125	active site
693978000126	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
693978000127	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
693978000128	active site
693978000129	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
693978000130	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
693978000131	Helix-turn-helix domains; Region: HTH; cl00088
693978000132	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
693978000133	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978000134	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
693978000135	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
693978000136	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
693978000137	substrate binding site [chemical binding]; other site
693978000138	oxyanion hole (OAH) forming residues; other site
693978000139	trimer interface [polypeptide binding]; other site
693978000140	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
693978000141	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
693978000142	dimer interface [polypeptide binding]; other site
693978000143	active site
693978000144	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
693978000145	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
693978000146	active site
693978000147	Protein of unknown function (DUF2400); Region: DUF2400; cl09884
693978000148	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
693978000149	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
693978000150	active site
693978000151	dimerization interface [polypeptide binding]; other site
693978000152	CAAX protease self-immunity; Region: Abi; cl00558
693978000153	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693978000154	active site
693978000155	adenylate kinase; Reviewed; Region: adk; PRK00279
693978000156	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
693978000157	AMP-binding site [chemical binding]; other site
693978000158	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
693978000159	GTPase CgtA; Reviewed; Region: obgE; PRK12299
693978000160	GTP1/OBG; Region: GTP1_OBG; pfam01018
693978000161	Obg GTPase; Region: Obg; cd01898
693978000162	G1 box; other site
693978000163	GTP/Mg2+ binding site [chemical binding]; other site
693978000164	Switch I region; other site
693978000165	G2 box; other site
693978000166	G3 box; other site
693978000167	Switch II region; other site
693978000168	G4 box; other site
693978000169	G5 box; other site
693978000170	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
693978000171	active site
693978000172	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
693978000173	active site
693978000174	oxyanion hole [active]
693978000175	catalytic triad [active]
693978000176	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
693978000177	FAD binding domain; Region: FAD_binding_4; pfam01565
693978000178	UbiA prenyltransferase family; Region: UbiA; cl00337
693978000179	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693978000180	ligand binding site [chemical binding]; other site
693978000181	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
693978000182	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
693978000183	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693978000184	phosphorylation site [posttranslational modification]
693978000185	dimer interface [polypeptide binding]; other site
693978000186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693978000187	ATP binding site [chemical binding]; other site
693978000188	Mg2+ binding site [ion binding]; other site
693978000189	G-X-G motif; other site
693978000190	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
693978000191	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961
693978000192	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978000193	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
693978000194	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
693978000195	nudix motif; other site
693978000196	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
693978000197	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
693978000198	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
693978000199	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
693978000200	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
693978000201	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258
693978000202	active site
693978000203	FlgD Ig-like domain; Region: FlgD_ig; cl15790
693978000204	Protein of unknown function (DUF3308); Region: DUF3308; cl14675
693978000205	Uncharacterized conserved protein [Function unknown]; Region: COG1912
693978000206	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
693978000207	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
693978000208	ABC-2 type transporter; Region: ABC2_membrane; cl11417
693978000209	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
693978000210	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693978000211	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
693978000212	putative ADP-binding pocket [chemical binding]; other site
693978000213	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
693978000214	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693978000215	ATP binding site [chemical binding]; other site
693978000216	putative Mg++ binding site [ion binding]; other site
693978000217	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693978000218	nucleotide binding region [chemical binding]; other site
693978000219	ATP-binding site [chemical binding]; other site
693978000220	RQC domain; Region: RQC; cl09632
693978000221	HRDC domain; Region: HRDC; cl02578
693978000222	KpsF/GutQ family protein; Region: kpsF; TIGR00393
693978000223	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
693978000224	putative active site [active]
693978000225	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
693978000226	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
693978000227	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
693978000228	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
693978000229	catalytic residues [active]
693978000230	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
693978000231	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
693978000232	dimer interface [polypeptide binding]; other site
693978000233	decamer (pentamer of dimers) interface [polypeptide binding]; other site
693978000234	catalytic triad [active]
693978000235	peroxidatic and resolving cysteines [active]
693978000236	aspartate aminotransferase; Provisional; Region: PRK05764
693978000237	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
693978000238	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978000239	homodimer interface [polypeptide binding]; other site
693978000240	catalytic residue [active]
693978000241	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
693978000242	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
693978000243	ligand binding site [chemical binding]; other site
693978000244	flexible hinge region; other site
693978000245	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
693978000246	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
693978000247	trmE is a tRNA modification GTPase; Region: trmE; cd04164
693978000248	G1 box; other site
693978000249	GTP/Mg2+ binding site [chemical binding]; other site
693978000250	Switch I region; other site
693978000251	G2 box; other site
693978000252	Switch II region; other site
693978000253	G3 box; other site
693978000254	G4 box; other site
693978000255	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
693978000256	Domain of unknown function (DUF336); Region: DUF336; cl01249
693978000257	Domain of unknown function (DUF336); Region: DUF336; cl01249
693978000258	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
693978000259	active site
693978000260	homotetramer interface [polypeptide binding]; other site
693978000261	YceI-like domain; Region: YceI; cl01001
693978000262	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
693978000263	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693978000264	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693978000265	DNA binding residues [nucleotide binding]
693978000266	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
693978000267	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
693978000268	active site
693978000269	catalytic residues [active]
693978000270	WbqC-like protein family; Region: WbqC; pfam08889
693978000271	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
693978000272	Catalytic site [active]
693978000273	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
693978000274	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
693978000275	dihydrodipicolinate reductase; Provisional; Region: PRK00048
693978000276	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978000277	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
693978000278	ParB-like partition proteins; Region: parB_part; TIGR00180
693978000279	ParB-like nuclease domain; Region: ParBc; cl02129
693978000280	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
693978000281	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
693978000282	P-loop; other site
693978000283	Magnesium ion binding site [ion binding]; other site
693978000284	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
693978000285	Magnesium ion binding site [ion binding]; other site
693978000286	Gram-negative bacterial tonB protein; Region: TonB; cl10048
693978000287	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
693978000288	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
693978000289	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
693978000290	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
693978000291	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978000292	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
693978000293	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
693978000294	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
693978000295	DNA polymerase III, delta subunit; Region: holA; TIGR01128
693978000296	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
693978000297	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
693978000298	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
693978000299	Substrate-binding site [chemical binding]; other site
693978000300	Substrate specificity [chemical binding]; other site
693978000301	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978000302	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
693978000303	NlpC/P60 family; Region: NLPC_P60; cl11438
693978000304	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
693978000305	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
693978000306	trimer interface [polypeptide binding]; other site
693978000307	active site
693978000308	substrate binding site [chemical binding]; other site
693978000309	CoA binding site [chemical binding]; other site
693978000310	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
693978000311	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
693978000312	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
693978000313	Ligand binding site; other site
693978000314	Putative Catalytic site; other site
693978000315	DXD motif; other site
693978000316	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
693978000317	putative active site [active]
693978000318	putative catalytic site [active]
693978000319	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693978000320	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
693978000321	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
693978000322	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
693978000323	ATP-grasp domain; Region: ATP-grasp_4; cl03087
693978000324	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
693978000325	GMP synthase; Reviewed; Region: guaA; PRK00074
693978000326	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
693978000327	AMP/PPi binding site [chemical binding]; other site
693978000328	candidate oxyanion hole; other site
693978000329	catalytic triad [active]
693978000330	potential glutamine specificity residues [chemical binding]; other site
693978000331	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
693978000332	ATP Binding subdomain [chemical binding]; other site
693978000333	Ligand Binding sites [chemical binding]; other site
693978000334	Dimerization subdomain; other site
693978000335	Mechanosensitive ion channel; Region: MS_channel; pfam00924
693978000336	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
693978000337	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
693978000338	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978000339	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
693978000340	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
693978000341	catalytic residue [active]
693978000342	4Fe-4S binding domain; Region: Fer4; cl02805
693978000343	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
693978000344	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
693978000345	NAD(P) binding site [chemical binding]; other site
693978000346	catalytic residues [active]
693978000347	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
693978000348	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
693978000349	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
693978000350	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
693978000351	Protein of unknown function (DUF493); Region: DUF493; cl01102
693978000352	Domain of unknown function (DUF4294); Region: DUF4294; pfam14127
693978000353	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
693978000354	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
693978000355	oligomer interface [polypeptide binding]; other site
693978000356	active site
693978000357	metal binding site [ion binding]; metal-binding site
693978000358	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978000359	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
693978000360	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
693978000361	active site
693978000362	metal binding site [ion binding]; metal-binding site
693978000363	nudix motif; other site
693978000364	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
693978000365	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
693978000366	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
693978000367	Sulfatase; Region: Sulfatase; cl10460
693978000368	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
693978000369	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
693978000370	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693978000371	binding surface
693978000372	TPR motif; other site
693978000373	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978000374	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693978000375	active site
693978000376	DNA binding site [nucleotide binding]
693978000377	Int/Topo IB signature motif; other site
693978000378	Fic family protein [Function unknown]; Region: COG3177
693978000379	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
693978000380	Fic/DOC family; Region: Fic; cl00960
693978000381	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
693978000382	DNA binding residues [nucleotide binding]
693978000383	AntA/AntB antirepressor; Region: AntA; cl01430
693978000384	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693978000385	non-specific DNA binding site [nucleotide binding]; other site
693978000386	salt bridge; other site
693978000387	sequence-specific DNA binding site [nucleotide binding]; other site
693978000388	Protein of unknown function (DUF2693); Region: DUF2693; pfam10902
693978000389	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
693978000390	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
693978000391	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
693978000392	ArsC family; Region: ArsC; pfam03960
693978000393	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
693978000394	ligand binding site [chemical binding]; other site
693978000395	flexible hinge region; other site
693978000396	NlpE N-terminal domain; Region: NlpE; cl01138
693978000397	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693978000398	active site
693978000399	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
693978000400	active site
693978000401	dimer interface [polypeptide binding]; other site
693978000402	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
693978000403	active site
693978000404	catalytic triad [active]
693978000405	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
693978000406	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
693978000407	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978000408	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
693978000409	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
693978000410	dimerization interface [polypeptide binding]; other site
693978000411	putative ATP binding site [chemical binding]; other site
693978000412	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
693978000413	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
693978000414	active site
693978000415	substrate binding site [chemical binding]; other site
693978000416	cosubstrate binding site; other site
693978000417	catalytic site [active]
693978000418	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
693978000419	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
693978000420	dimer interface [polypeptide binding]; other site
693978000421	anticodon binding site; other site
693978000422	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
693978000423	homodimer interface [polypeptide binding]; other site
693978000424	motif 1; other site
693978000425	active site
693978000426	motif 2; other site
693978000427	GAD domain; Region: GAD; pfam02938
693978000428	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
693978000429	motif 3; other site
693978000430	asparagine synthetase B; Provisional; Region: asnB; PRK09431
693978000431	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
693978000432	active site
693978000433	dimer interface [polypeptide binding]; other site
693978000434	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
693978000435	Ligand Binding Site [chemical binding]; other site
693978000436	Molecular Tunnel; other site
693978000437	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
693978000438	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
693978000439	RNA binding surface [nucleotide binding]; other site
693978000440	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
693978000441	active site
693978000442	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
693978000443	ABC-type multidrug transport system, ATPase component.  The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily.  ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264
693978000444	Walker A/P-loop; other site
693978000445	ATP binding site [chemical binding]; other site
693978000446	Q-loop/lid; other site
693978000447	ABC transporter signature motif; other site
693978000448	Walker B; other site
693978000449	D-loop; other site
693978000450	H-loop/switch region; other site
693978000451	ABC-2 type transporter; Region: ABC2_membrane; cl11417
693978000452	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
693978000453	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
693978000454	Zn binding site [ion binding]; other site
693978000455	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
693978000456	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
693978000457	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
693978000458	active site
693978000459	catalytic triad [active]
693978000460	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
693978000461	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
693978000462	Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675
693978000463	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978000464	recombination protein RecR; Reviewed; Region: recR; PRK00076
693978000465	RecR protein; Region: RecR; pfam02132
693978000466	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
693978000467	putative active site [active]
693978000468	putative metal-binding site [ion binding]; other site
693978000469	tetramer interface [polypeptide binding]; other site
693978000470	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
693978000471	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
693978000472	Probable Catalytic site; other site
693978000473	metal-binding site
693978000474	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693978000475	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
693978000476	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693978000477	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693978000478	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
693978000479	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693978000480	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
693978000481	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978000482	Family description; Region: UvrD_C_2; cl15862
693978000483	DNA polymerase I; Provisional; Region: PRK05755
693978000484	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
693978000485	active site
693978000486	metal binding site 1 [ion binding]; metal-binding site
693978000487	putative 5' ssDNA interaction site; other site
693978000488	metal binding site 3; metal-binding site
693978000489	metal binding site 2 [ion binding]; metal-binding site
693978000490	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
693978000491	putative DNA binding site [nucleotide binding]; other site
693978000492	putative metal binding site [ion binding]; other site
693978000493	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
693978000494	active site
693978000495	catalytic site [active]
693978000496	substrate binding site [chemical binding]; other site
693978000497	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
693978000498	active site
693978000499	DNA binding site [nucleotide binding]
693978000500	catalytic site [active]
693978000501	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978000502	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978000503	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
693978000504	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
693978000505	DXD motif; other site
693978000506	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978000507	GTPase Era; Reviewed; Region: era; PRK00089
693978000508	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
693978000509	G1 box; other site
693978000510	GTP/Mg2+ binding site [chemical binding]; other site
693978000511	Switch I region; other site
693978000512	G2 box; other site
693978000513	Switch II region; other site
693978000514	G3 box; other site
693978000515	G4 box; other site
693978000516	G5 box; other site
693978000517	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
693978000518	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
693978000519	Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268
693978000520	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
693978000521	Potassium binding sites [ion binding]; other site
693978000522	Cesium cation binding sites [ion binding]; other site
693978000523	YhhN-like protein; Region: YhhN; cl01505
693978000524	PhoD-like phosphatase; Region: PhoD; pfam09423
693978000525	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
693978000526	active site
693978000527	metal binding site [ion binding]; metal-binding site
693978000528	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978000529	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
693978000530	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
693978000531	putative rRNA binding site [nucleotide binding]; other site
693978000532	phosphodiesterase; Provisional; Region: PRK12704
693978000533	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
693978000534	Cell division protein ZapA; Region: ZapA; cl01146
693978000535	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
693978000536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
693978000537	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
693978000538	anchoring element; other site
693978000539	dimer interface [polypeptide binding]; other site
693978000540	ATP binding site [chemical binding]; other site
693978000541	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
693978000542	active site
693978000543	putative metal-binding site [ion binding]; other site
693978000544	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
693978000545	DNA topoisomerase IV subunit A; Provisional; Region: PRK12758
693978000546	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148
693978000547	CAP-like domain; other site
693978000548	active site
693978000549	primary dimer interface [polypeptide binding]; other site
693978000550	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
693978000551	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
693978000552	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
693978000553	synthetase active site [active]
693978000554	NTP binding site [chemical binding]; other site
693978000555	metal binding site [ion binding]; metal-binding site
693978000556	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
693978000557	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
693978000558	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
693978000559	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
693978000560	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
693978000561	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
693978000562	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
693978000563	substrate binding site [chemical binding]; other site
693978000564	active site
693978000565	catalytic residues [active]
693978000566	heterodimer interface [polypeptide binding]; other site
693978000567	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
693978000568	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
693978000569	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978000570	catalytic residue [active]
693978000571	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
693978000572	active site
693978000573	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
693978000574	active site
693978000575	ribulose/triose binding site [chemical binding]; other site
693978000576	phosphate binding site [ion binding]; other site
693978000577	substrate (anthranilate) binding pocket [chemical binding]; other site
693978000578	product (indole) binding pocket [chemical binding]; other site
693978000579	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
693978000580	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
693978000581	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
693978000582	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
693978000583	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
693978000584	Glutamine amidotransferase class-I; Region: GATase; pfam00117
693978000585	glutamine binding [chemical binding]; other site
693978000586	catalytic triad [active]
693978000587	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
693978000588	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
693978000589	chorismate binding enzyme; Region: Chorismate_bind; cl10555
693978000590	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
693978000591	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
693978000592	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
693978000593	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
693978000594	active site
693978000595	dimer interface [polypeptide binding]; other site
693978000596	motif 1; other site
693978000597	motif 2; other site
693978000598	motif 3; other site
693978000599	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
693978000600	anticodon binding site; other site
693978000601	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
693978000602	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
693978000603	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
693978000604	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
693978000605	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
693978000606	23S rRNA binding site [nucleotide binding]; other site
693978000607	L21 binding site [polypeptide binding]; other site
693978000608	L13 binding site [polypeptide binding]; other site
693978000609	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
693978000610	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978000611	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
693978000612	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
693978000613	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
693978000614	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
693978000615	dimerization interface [polypeptide binding]; other site
693978000616	ATP binding site [chemical binding]; other site
693978000617	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
693978000618	dimerization interface [polypeptide binding]; other site
693978000619	ATP binding site [chemical binding]; other site
693978000620	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
693978000621	putative active site [active]
693978000622	catalytic triad [active]
693978000623	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
693978000624	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
693978000625	ATP binding site [chemical binding]; other site
693978000626	active site
693978000627	substrate binding site [chemical binding]; other site
693978000628	amidophosphoribosyltransferase; Region: purF; TIGR01134
693978000629	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
693978000630	active site
693978000631	tetramer interface [polypeptide binding]; other site
693978000632	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693978000633	active site
693978000634	Cupin domain; Region: Cupin_2; cl09118
693978000635	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693978000636	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693978000637	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
693978000638	putative active site [active]
693978000639	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
693978000640	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
693978000641	dimer interface [polypeptide binding]; other site
693978000642	putative anticodon binding site; other site
693978000643	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
693978000644	motif 1; other site
693978000645	active site
693978000646	motif 2; other site
693978000647	motif 3; other site
693978000648	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
693978000649	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
693978000650	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
693978000651	GDP-binding site [chemical binding]; other site
693978000652	ACT binding site; other site
693978000653	IMP binding site; other site
693978000654	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693978000655	catalytic residues [active]
693978000656	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
693978000657	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
693978000658	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
693978000659	G1 box; other site
693978000660	putative GEF interaction site [polypeptide binding]; other site
693978000661	GTP/Mg2+ binding site [chemical binding]; other site
693978000662	Switch I region; other site
693978000663	G2 box; other site
693978000664	G3 box; other site
693978000665	Switch II region; other site
693978000666	G4 box; other site
693978000667	G5 box; other site
693978000668	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
693978000669	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
693978000670	Protein of unknown function (DUF465); Region: DUF465; cl01070
693978000671	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
693978000672	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
693978000673	ATP-binding site [chemical binding]; other site
693978000674	Sugar specificity; other site
693978000675	Pyrimidine base specificity; other site
693978000676	Septum formation initiator; Region: DivIC; cl11433
693978000677	GTPase RsgA; Reviewed; Region: PRK00098
693978000678	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
693978000679	RNA binding site [nucleotide binding]; other site
693978000680	homodimer interface [polypeptide binding]; other site
693978000681	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
693978000682	GTPase/Zn-binding domain interface [polypeptide binding]; other site
693978000683	GTP/Mg2+ binding site [chemical binding]; other site
693978000684	G4 box; other site
693978000685	G5 box; other site
693978000686	G1 box; other site
693978000687	Switch I region; other site
693978000688	G2 box; other site
693978000689	G3 box; other site
693978000690	Switch II region; other site
693978000691	Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
693978000692	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
693978000693	substrate binding site [chemical binding]; other site
693978000694	dimer interface [polypeptide binding]; other site
693978000695	catalytic triad [active]
693978000696	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
693978000697	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
693978000698	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
693978000699	dimerization interface [polypeptide binding]; other site
693978000700	putative DNA binding site [nucleotide binding]; other site
693978000701	putative Zn2+ binding site [ion binding]; other site
693978000702	signal recognition particle protein; Provisional; Region: PRK10867
693978000703	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
693978000704	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
693978000705	P loop; other site
693978000706	GTP binding site [chemical binding]; other site
693978000707	Signal peptide binding domain; Region: SRP_SPB; pfam02978
693978000708	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
693978000709	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
693978000710	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693978000711	S-adenosylmethionine binding site [chemical binding]; other site
693978000712	Protein of unknown function (DUF328); Region: DUF328; cl01143
693978000713	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
693978000714	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
693978000715	purine monophosphate binding site [chemical binding]; other site
693978000716	dimer interface [polypeptide binding]; other site
693978000717	putative catalytic residues [active]
693978000718	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
693978000719	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
693978000720	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978000721	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
693978000722	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
693978000723	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
693978000724	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
693978000725	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
693978000726	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
693978000727	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
693978000728	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
693978000729	RNA binding site [nucleotide binding]; other site
693978000730	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
693978000731	RNA binding site [nucleotide binding]; other site
693978000732	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
693978000733	RNA binding site [nucleotide binding]; other site
693978000734	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
693978000735	RNA binding site [nucleotide binding]; other site
693978000736	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
693978000737	RNA binding site [nucleotide binding]; other site
693978000738	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
693978000739	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
693978000740	active site
693978000741	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
693978000742	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
693978000743	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
693978000744	Cytochrome c; Region: Cytochrom_C; cl11414
693978000745	potential frameshift: common BLAST hit: gi|146302191|ref|YP_001196782.1| CzcA family heavy metal efflux protein
693978000746	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
693978000747	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
693978000748	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
693978000749	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
693978000750	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
693978000751	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
693978000752	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
693978000753	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
693978000754	substrate binding site [chemical binding]; other site
693978000755	oxyanion hole (OAH) forming residues; other site
693978000756	trimer interface [polypeptide binding]; other site
693978000757	UbiA prenyltransferase family; Region: UbiA; cl00337
693978000758	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
693978000759	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978000760	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
693978000761	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
693978000762	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
693978000763	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
693978000764	active site
693978000765	Zn binding site [ion binding]; other site
693978000766	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
693978000767	RNAase interaction site [polypeptide binding]; other site
693978000768	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
693978000769	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
693978000770	active site
693978000771	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
693978000772	THUMP domain; Region: THUMP; cl12076
693978000773	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
693978000774	acetyl-CoA synthetase; Provisional; Region: PRK00174
693978000775	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
693978000776	AMP-binding enzyme; Region: AMP-binding; cl15778
693978000777	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
693978000778	helicase 45; Provisional; Region: PTZ00424
693978000779	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
693978000780	ATP binding site [chemical binding]; other site
693978000781	Mg++ binding site [ion binding]; other site
693978000782	motif III; other site
693978000783	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693978000784	nucleotide binding region [chemical binding]; other site
693978000785	ATP-binding site [chemical binding]; other site
693978000786	DbpA RNA binding domain; Region: DbpA; pfam03880
693978000787	YtxH-like protein; Region: YtxH; cl02079
693978000788	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693978000789	TPR motif; other site
693978000790	binding surface
693978000791	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
693978000792	DNA gyrase subunit A; Validated; Region: PRK05560
693978000793	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
693978000794	CAP-like domain; other site
693978000795	active site
693978000796	primary dimer interface [polypeptide binding]; other site
693978000797	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
693978000798	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
693978000799	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
693978000800	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
693978000801	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
693978000802	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
693978000803	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
693978000804	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
693978000805	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693978000806	ATP binding site [chemical binding]; other site
693978000807	Mg2+ binding site [ion binding]; other site
693978000808	G-X-G motif; other site
693978000809	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
693978000810	anchoring element; other site
693978000811	dimer interface [polypeptide binding]; other site
693978000812	ATP binding site [chemical binding]; other site
693978000813	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
693978000814	active site
693978000815	putative metal-binding site [ion binding]; other site
693978000816	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
693978000817	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
693978000818	dimer interface [polypeptide binding]; other site
693978000819	ssDNA binding site [nucleotide binding]; other site
693978000820	tetramer (dimer of dimers) interface [polypeptide binding]; other site
693978000821	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
693978000822	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693978000823	active site
693978000824	DNA binding site [nucleotide binding]
693978000825	Int/Topo IB signature motif; other site
693978000826	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
693978000827	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
693978000828	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
693978000829	active site
693978000830	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
693978000831	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
693978000832	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656
693978000833	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978000834	hypothetical protein; Provisional; Region: PRK06753
693978000835	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
693978000836	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
693978000837	E3 interaction surface; other site
693978000838	lipoyl attachment site [posttranslational modification]; other site
693978000839	e3 binding domain; Region: E3_binding; pfam02817
693978000840	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
693978000841	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
693978000842	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
693978000843	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239
693978000844	putative active site [active]
693978000845	Zn binding site [ion binding]; other site
693978000846	Integral membrane protein TerC family; Region: TerC; cl10468
693978000847	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693978000848	non-specific DNA binding site [nucleotide binding]; other site
693978000849	salt bridge; other site
693978000850	sequence-specific DNA binding site [nucleotide binding]; other site
693978000851	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
693978000852	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
693978000853	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
693978000854	catalytic residues [active]
693978000855	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
693978000856	metal binding site [ion binding]; metal-binding site
693978000857	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
693978000858	active site
693978000859	catalytic motif [active]
693978000860	Zn binding site [ion binding]; other site
693978000861	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
693978000862	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
693978000863	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
693978000864	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
693978000865	Predicted acetyltransferase [General function prediction only]; Region: COG3153
693978000866	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
693978000867	Coenzyme A binding pocket [chemical binding]; other site
693978000868	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
693978000869	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
693978000870	DNA binding residues [nucleotide binding]
693978000871	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
693978000872	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
693978000873	Probable Catalytic site; other site
693978000874	metal-binding site
693978000875	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
693978000876	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
693978000877	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
693978000878	putative acyl-acceptor binding pocket; other site
693978000879	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
693978000880	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
693978000881	ArsC family; Region: ArsC; pfam03960
693978000882	catalytic residues [active]
693978000883	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
693978000884	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
693978000885	dimer interface [polypeptide binding]; other site
693978000886	motif 1; other site
693978000887	active site
693978000888	motif 2; other site
693978000889	motif 3; other site
693978000890	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
693978000891	anticodon binding site; other site
693978000892	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
693978000893	Isochorismatase family; Region: Isochorismatase; pfam00857
693978000894	catalytic triad [active]
693978000895	metal binding site [ion binding]; metal-binding site
693978000896	conserved cis-peptide bond; other site
693978000897	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978000898	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
693978000899	active site
693978000900	motif I; other site
693978000901	motif II; other site
693978000902	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
693978000903	active site
693978000904	prephenate dehydratase; Provisional; Region: PRK11898
693978000905	Prephenate dehydratase; Region: PDT; pfam00800
693978000906	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
693978000907	putative L-Phe binding site [chemical binding]; other site
693978000908	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
693978000909	Ligand Binding Site [chemical binding]; other site
693978000910	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
693978000911	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
693978000912	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
693978000913	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
693978000914	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
693978000915	Protein export membrane protein; Region: SecD_SecF; cl14618
693978000916	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
693978000917	Protein export membrane protein; Region: SecD_SecF; cl14618
693978000918	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
693978000919	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693978000920	FeS/SAM binding site; other site
693978000921	HemN C-terminal domain; Region: HemN_C; pfam06969
693978000922	Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326
693978000923	Na binding site [ion binding]; other site
693978000924	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
693978000925	TPP-binding site [chemical binding]; other site
693978000926	dimer interface [polypeptide binding]; other site
693978000927	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
693978000928	Domain of unknown function (DUF336); Region: DUF336; cl01249
693978000929	Protein of unknown function, DUF417; Region: DUF417; cl01162
693978000930	Domain of unknown function (DUF336); Region: DUF336; cl01249
693978000931	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
693978000932	active site
693978000933	homotetramer interface [polypeptide binding]; other site
693978000934	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
693978000935	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
693978000936	PYR/PP interface [polypeptide binding]; other site
693978000937	dimer interface [polypeptide binding]; other site
693978000938	TPP binding site [chemical binding]; other site
693978000939	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
693978000940	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
693978000941	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978000942	NAD(P) binding site [chemical binding]; other site
693978000943	active site
693978000944	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
693978000945	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
693978000946	ring oligomerisation interface [polypeptide binding]; other site
693978000947	ATP/Mg binding site [chemical binding]; other site
693978000948	stacking interactions; other site
693978000949	hinge regions; other site
693978000950	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
693978000951	oligomerisation interface [polypeptide binding]; other site
693978000952	mobile loop; other site
693978000953	roof hairpin; other site
693978000954	META domain; Region: META; cl01245
693978000955	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
693978000956	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
693978000957	putative tRNA-binding site [nucleotide binding]; other site
693978000958	B3/4 domain; Region: B3_4; cl11458
693978000959	tRNA synthetase B5 domain; Region: B5; cl08394
693978000960	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
693978000961	dimer interface [polypeptide binding]; other site
693978000962	motif 1; other site
693978000963	motif 3; other site
693978000964	motif 2; other site
693978000965	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
693978000966	DNA polymerase III subunit beta; Validated; Region: PRK05643
693978000967	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
693978000968	putative DNA binding surface [nucleotide binding]; other site
693978000969	dimer interface [polypeptide binding]; other site
693978000970	beta-clamp/clamp loader binding surface; other site
693978000971	beta-clamp/translesion DNA polymerase binding surface; other site
693978000972	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
693978000973	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
693978000974	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
693978000975	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
693978000976	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
693978000977	active site
693978000978	metal binding site [ion binding]; metal-binding site
693978000979	UDP-glucose 4-epimerase; Region: PLN02240
693978000980	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
693978000981	NAD binding site [chemical binding]; other site
693978000982	homodimer interface [polypeptide binding]; other site
693978000983	active site
693978000984	substrate binding site [chemical binding]; other site
693978000985	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
693978000986	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
693978000987	inhibitor-cofactor binding pocket; inhibition site
693978000988	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978000989	catalytic residue [active]
693978000990	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
693978000991	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
693978000992	tetramer interface [polypeptide binding]; other site
693978000993	TPP-binding site [chemical binding]; other site
693978000994	heterodimer interface [polypeptide binding]; other site
693978000995	phosphorylation loop region [posttranslational modification]
693978000996	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
693978000997	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
693978000998	PYR/PP interface [polypeptide binding]; other site
693978000999	dimer interface [polypeptide binding]; other site
693978001000	TPP binding site [chemical binding]; other site
693978001001	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
693978001002	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693978001003	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
693978001004	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693978001005	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693978001006	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693978001007	Peptidase S46; Region: Peptidase_S46; pfam10459
693978001008	Domain of unknown function (DUF4268); Region: DUF4268; pfam14088
693978001009	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
693978001010	intersubunit interface [polypeptide binding]; other site
693978001011	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
693978001012	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
693978001013	tetramer interface [polypeptide binding]; other site
693978001014	active site
693978001015	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
693978001016	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
693978001017	active site
693978001018	HIGH motif; other site
693978001019	KMSKS motif; other site
693978001020	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
693978001021	tRNA binding surface [nucleotide binding]; other site
693978001022	anticodon binding site; other site
693978001023	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
693978001024	dimer interface [polypeptide binding]; other site
693978001025	putative tRNA-binding site [nucleotide binding]; other site
693978001026	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
693978001027	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
693978001028	active site
693978001029	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
693978001030	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
693978001031	ATP binding site [chemical binding]; other site
693978001032	Mg++ binding site [ion binding]; other site
693978001033	motif III; other site
693978001034	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693978001035	nucleotide binding region [chemical binding]; other site
693978001036	ATP-binding site [chemical binding]; other site
693978001037	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
693978001038	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
693978001039	dimer interface [polypeptide binding]; other site
693978001040	active site
693978001041	metal binding site [ion binding]; metal-binding site
693978001042	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
693978001043	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
693978001044	FAD binding site [chemical binding]; other site
693978001045	homotetramer interface [polypeptide binding]; other site
693978001046	substrate binding pocket [chemical binding]; other site
693978001047	catalytic base [active]
693978001048	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
693978001049	AMP-binding enzyme; Region: AMP-binding; cl15778
693978001050	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
693978001051	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
693978001052	G1 box; other site
693978001053	putative GEF interaction site [polypeptide binding]; other site
693978001054	GTP/Mg2+ binding site [chemical binding]; other site
693978001055	Switch I region; other site
693978001056	G2 box; other site
693978001057	G3 box; other site
693978001058	Switch II region; other site
693978001059	G4 box; other site
693978001060	G5 box; other site
693978001061	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
693978001062	Ion transport protein; Region: Ion_trans; pfam00520
693978001063	Ion channel; Region: Ion_trans_2; cl11596
693978001064	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
693978001065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
693978001066	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
693978001067	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
693978001068	Putative zinc ribbon domain; Region: DUF164; pfam02591
693978001069	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
693978001070	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
693978001071	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
693978001072	recombination protein F; Reviewed; Region: recF; PRK00064
693978001073	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978001074	Walker A/P-loop; other site
693978001075	ATP binding site [chemical binding]; other site
693978001076	Q-loop/lid; other site
693978001077	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978001078	ABC transporter signature motif; other site
693978001079	Walker B; other site
693978001080	D-loop; other site
693978001081	H-loop/switch region; other site
693978001082	UbiA prenyltransferase family; Region: UbiA; cl00337
693978001083	ResB-like family; Region: ResB; pfam05140
693978001084	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
693978001085	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
693978001086	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
693978001087	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
693978001088	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978001089	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
693978001090	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
693978001091	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
693978001092	E3 interaction surface; other site
693978001093	lipoyl attachment site [posttranslational modification]; other site
693978001094	e3 binding domain; Region: E3_binding; pfam02817
693978001095	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
693978001096	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
693978001097	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
693978001098	TPP-binding site [chemical binding]; other site
693978001099	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
693978001100	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
693978001101	hydrophobic ligand binding site; other site
693978001102	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
693978001103	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
693978001104	Domain of unknown function DUF21; Region: DUF21; pfam01595
693978001105	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
693978001106	Transporter associated domain; Region: CorC_HlyC; cl08393
693978001107	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
693978001108	ATP synthase; Region: ATP-synt; cl00365
693978001109	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
693978001110	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
693978001111	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
693978001112	beta subunit interaction interface [polypeptide binding]; other site
693978001113	Walker A motif; other site
693978001114	ATP binding site [chemical binding]; other site
693978001115	Walker B motif; other site
693978001116	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
693978001117	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
693978001118	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
693978001119	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
693978001120	ATP synthase A chain; Region: ATP-synt_A; cl00413
693978001121	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693978001122	Major Facilitator Superfamily; Region: MFS_1; pfam07690
693978001123	putative substrate translocation pore; other site
693978001124	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
693978001125	twin arginine translocase protein A; Validated; Region: tatE; PRK01614
693978001126	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
693978001127	active site
693978001128	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
693978001129	Recombination protein O N terminal; Region: RecO_N; cl15812
693978001130	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
693978001131	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978001132	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
693978001133	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
693978001134	active site
693978001135	metal binding site [ion binding]; metal-binding site
693978001136	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
693978001137	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
693978001138	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
693978001139	DNA binding site [nucleotide binding]
693978001140	active site
693978001141	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
693978001142	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
693978001143	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978001144	YceG-like family; Region: YceG; pfam02618
693978001145	proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675
693978001146	dimerization interface [polypeptide binding]; other site
693978001147	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
693978001148	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
693978001149	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
693978001150	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
693978001151	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693978001152	active site
693978001153	HIGH motif; other site
693978001154	nucleotide binding site [chemical binding]; other site
693978001155	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693978001156	active site
693978001157	KMSKS motif; other site
693978001158	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
693978001159	UbiA prenyltransferase family; Region: UbiA; cl00337
693978001160	mevalonate kinase; Region: mevalon_kin; TIGR00549
693978001161	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
693978001162	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
693978001163	putative active site [active]
693978001164	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
693978001165	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
693978001166	FAD binding pocket [chemical binding]; other site
693978001167	FAD binding motif [chemical binding]; other site
693978001168	phosphate binding motif [ion binding]; other site
693978001169	beta-alpha-beta structure motif; other site
693978001170	NAD(p) ribose binding residues [chemical binding]; other site
693978001171	NAD binding pocket [chemical binding]; other site
693978001172	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
693978001173	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
693978001174	catalytic loop [active]
693978001175	iron binding site [ion binding]; other site
693978001176	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
693978001177	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693978001178	catalytic residues [active]
693978001179	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
693978001180	ABC-ATPase subunit  interface; other site
693978001181	dimer interface [polypeptide binding]; other site
693978001182	putative PBP binding regions; other site
693978001183	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
693978001184	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
693978001185	Walker A/P-loop; other site
693978001186	ATP binding site [chemical binding]; other site
693978001187	Q-loop/lid; other site
693978001188	ABC transporter signature motif; other site
693978001189	Walker B; other site
693978001190	D-loop; other site
693978001191	H-loop/switch region; other site
693978001192	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
693978001193	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
693978001194	ATP-grasp domain; Region: ATP-grasp_4; cl03087
693978001195	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
693978001196	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
693978001197	ATP-grasp domain; Region: ATP-grasp_4; cl03087
693978001198	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
693978001199	IMP binding site; other site
693978001200	dimer interface [polypeptide binding]; other site
693978001201	interdomain contacts; other site
693978001202	partial ornithine binding site; other site
693978001203	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
693978001204	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
693978001205	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
693978001206	catalytic site [active]
693978001207	subunit interface [polypeptide binding]; other site
693978001208	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
693978001209	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
693978001210	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978001211	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
693978001212	active site
693978001213	homodimer interface [polypeptide binding]; other site
693978001214	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
693978001215	DNA-binding site [nucleotide binding]; DNA binding site
693978001216	RNA-binding motif; other site
693978001217	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
693978001218	DNA-binding site [nucleotide binding]; DNA binding site
693978001219	RNA-binding motif; other site
693978001220	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
693978001221	DEAD-like helicases superfamily; Region: DEXDc; smart00487
693978001222	ATP binding site [chemical binding]; other site
693978001223	Mg++ binding site [ion binding]; other site
693978001224	motif III; other site
693978001225	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693978001226	nucleotide binding region [chemical binding]; other site
693978001227	ATP-binding site [chemical binding]; other site
693978001228	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
693978001229	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693978001230	FeS/SAM binding site; other site
693978001231	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
693978001232	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
693978001233	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
693978001234	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978001235	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
693978001236	WYL domain; Region: WYL; cl14852
693978001237	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
693978001238	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
693978001239	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
693978001240	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
693978001241	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
693978001242	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
693978001243	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
693978001244	putative ion selectivity filter; other site
693978001245	putative pore gating glutamate residue; other site
693978001246	putative H+/Cl- coupling transport residue; other site
693978001247	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
693978001248	Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528
693978001249	ATP binding site [chemical binding]; other site
693978001250	profilin binding site; other site
693978001251	Domain of unknown function (DUF955); Region: DUF955; cl01076
693978001252	primosome assembly protein PriA; Validated; Region: PRK05580
693978001253	primosome assembly protein PriA; Validated; Region: PRK05580
693978001254	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693978001255	ATP binding site [chemical binding]; other site
693978001256	putative Mg++ binding site [ion binding]; other site
693978001257	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978001258	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
693978001259	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
693978001260	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
693978001261	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
693978001262	substrate-cofactor binding pocket; other site
693978001263	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978001264	catalytic residue [active]
693978001265	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
693978001266	Mrr N-terminal domain; Region: Mrr_N; pfam14338
693978001267	Restriction endonuclease; Region: Mrr_cat; cl00516
693978001268	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
693978001269	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
693978001270	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
693978001271	dimer interface [polypeptide binding]; other site
693978001272	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978001273	catalytic residue [active]
693978001274	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
693978001275	BlaR1 peptidase M56; Region: Peptidase_M56; cl15829
693978001276	Helix-turn-helix domains; Region: HTH; cl00088
693978001277	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
693978001278	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978001279	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
693978001280	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
693978001281	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
693978001282	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978001283	active site
693978001284	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
693978001285	catalytic residues [active]
693978001286	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
693978001287	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
693978001288	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
693978001289	catalytic residue [active]
693978001290	PrcB C-terminal; Region: PrcB_C; pfam14343
693978001291	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
693978001292	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
693978001293	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978001294	NAD(P) binding site [chemical binding]; other site
693978001295	active site
693978001296	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
693978001297	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
693978001298	substrate binding pocket [chemical binding]; other site
693978001299	chain length determination region; other site
693978001300	substrate-Mg2+ binding site; other site
693978001301	catalytic residues [active]
693978001302	aspartate-rich region 1; other site
693978001303	active site lid residues [active]
693978001304	aspartate-rich region 2; other site
693978001305	Trm112p-like protein; Region: Trm112p; cl01066
693978001306	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
693978001307	thiamine phosphate binding site [chemical binding]; other site
693978001308	active site
693978001309	pyrophosphate binding site [ion binding]; other site
693978001310	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
693978001311	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
693978001312	dimerization interface [polypeptide binding]; other site
693978001313	putative ATP binding site [chemical binding]; other site
693978001314	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693978001315	S-adenosylmethionine binding site [chemical binding]; other site
693978001316	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
693978001317	hypothetical protein; Provisional; Region: PRK08201
693978001318	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
693978001319	metal binding site [ion binding]; metal-binding site
693978001320	putative dimer interface [polypeptide binding]; other site
693978001321	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693978001322	ligand binding site [chemical binding]; other site
693978001323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
693978001324	shikimate kinase; Reviewed; Region: aroK; PRK00131
693978001325	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
693978001326	ADP binding site [chemical binding]; other site
693978001327	magnesium binding site [ion binding]; other site
693978001328	putative shikimate binding site; other site
693978001329	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
693978001330	RNA binding surface [nucleotide binding]; other site
693978001331	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
693978001332	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
693978001333	generic binding surface II; other site
693978001334	ssDNA binding site; other site
693978001335	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693978001336	ATP binding site [chemical binding]; other site
693978001337	putative Mg++ binding site [ion binding]; other site
693978001338	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693978001339	nucleotide binding region [chemical binding]; other site
693978001340	ATP-binding site [chemical binding]; other site
693978001341	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
693978001342	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978001343	Walker A/P-loop; other site
693978001344	ATP binding site [chemical binding]; other site
693978001345	Q-loop/lid; other site
693978001346	ABC transporter signature motif; other site
693978001347	Walker B; other site
693978001348	D-loop; other site
693978001349	H-loop/switch region; other site
693978001350	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
693978001351	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
693978001352	PhnA protein; Region: PhnA; pfam03831
693978001353	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
693978001354	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
693978001355	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
693978001356	catalytic residue [active]
693978001357	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
693978001358	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
693978001359	Zn binding site [ion binding]; other site
693978001360	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
693978001361	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
693978001362	substrate binding pocket [chemical binding]; other site
693978001363	chain length determination region; other site
693978001364	substrate-Mg2+ binding site; other site
693978001365	catalytic residues [active]
693978001366	aspartate-rich region 1; other site
693978001367	active site lid residues [active]
693978001368	aspartate-rich region 2; other site
693978001369	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
693978001370	nudix motif; other site
693978001371	Helix-turn-helix domains; Region: HTH; cl00088
693978001372	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
693978001373	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
693978001374	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
693978001375	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
693978001376	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
693978001377	Phosphate transporter family; Region: PHO4; cl00396
693978001378	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
693978001379	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
693978001380	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
693978001381	THF binding site; other site
693978001382	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
693978001383	substrate binding site [chemical binding]; other site
693978001384	THF binding site; other site
693978001385	zinc-binding site [ion binding]; other site
693978001386	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
693978001387	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
693978001388	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
693978001389	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
693978001390	Surface antigen; Region: Bac_surface_Ag; cl03097
693978001391	NeuB family; Region: NeuB; cl00496
693978001392	Chorismate mutase type II; Region: CM_2; cl00693
693978001393	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14970
693978001394	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978001395	Walker A motif; other site
693978001396	ATP binding site [chemical binding]; other site
693978001397	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978001398	Walker B motif; other site
693978001399	arginine finger; other site
693978001400	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
693978001401	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
693978001402	dimer interface [polypeptide binding]; other site
693978001403	substrate binding site [chemical binding]; other site
693978001404	metal binding sites [ion binding]; metal-binding site
693978001405	hypothetical protein; Reviewed; Region: PRK00024
693978001406	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
693978001407	MPN+ (JAMM) motif; other site
693978001408	Zinc-binding site [ion binding]; other site
693978001409	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
693978001410	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
693978001411	Walker A/P-loop; other site
693978001412	ATP binding site [chemical binding]; other site
693978001413	Q-loop/lid; other site
693978001414	ABC transporter signature motif; other site
693978001415	Walker B; other site
693978001416	D-loop; other site
693978001417	H-loop/switch region; other site
693978001418	LrgA family; Region: LrgA; cl00608
693978001419	LrgB-like family; Region: LrgB; cl00596
693978001420	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
693978001421	dihydropteroate synthase; Region: DHPS; TIGR01496
693978001422	substrate binding pocket [chemical binding]; other site
693978001423	dimer interface [polypeptide binding]; other site
693978001424	inhibitor binding site; inhibition site
693978001425	cytidylate kinase; Provisional; Region: cmk; PRK00023
693978001426	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
693978001427	CMP-binding site; other site
693978001428	The sites determining sugar specificity; other site
693978001429	Predicted integral membrane protein [Function unknown]; Region: COG0392
693978001430	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
693978001431	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
693978001432	tetramerization interface [polypeptide binding]; other site
693978001433	active site
693978001434	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
693978001435	IHF - DNA interface [nucleotide binding]; other site
693978001436	IHF dimer interface [polypeptide binding]; other site
693978001437	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
693978001438	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
693978001439	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
693978001440	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
693978001441	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
693978001442	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
693978001443	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
693978001444	metal binding site [ion binding]; metal-binding site
693978001445	dimer interface [polypeptide binding]; other site
693978001446	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
693978001447	putative catalytic site [active]
693978001448	putative metal binding site [ion binding]; other site
693978001449	putative phosphate binding site [ion binding]; other site
693978001450	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
693978001451	Tetramer interface [polypeptide binding]; other site
693978001452	active site
693978001453	FMN-binding site [chemical binding]; other site
693978001454	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693978001455	catalytic residues [active]
693978001456	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
693978001457	lipoyl synthase; Provisional; Region: PRK05481
693978001458	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693978001459	FeS/SAM binding site; other site
693978001460	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
693978001461	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693978001462	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693978001463	DNA binding residues [nucleotide binding]
693978001464	Ribosome-binding factor A; Region: RBFA; cl00542
693978001465	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
693978001466	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693978001467	FtsX-like permease family; Region: FtsX; cl15850
693978001468	Endonuclease I; Region: Endonuclease_1; cl01003
693978001469	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978001470	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
693978001471	Alkaline phosphatase homologues; Region: alkPPc; smart00098
693978001472	active site
693978001473	dimer interface [polypeptide binding]; other site
693978001474	competence damage-inducible protein A; Provisional; Region: PRK00549
693978001475	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
693978001476	putative MPT binding site; other site
693978001477	Competence-damaged protein; Region: CinA; cl00666
693978001478	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
693978001479	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
693978001480	active site
693978001481	Zn binding site [ion binding]; other site
693978001482	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
693978001483	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
693978001484	active site
693978001485	catalytic site [active]
693978001486	substrate binding site [chemical binding]; other site
693978001487	exodeoxyribonuclease X; Provisional; Region: PRK07983
693978001488	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
693978001489	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
693978001490	Ligand Binding Site [chemical binding]; other site
693978001491	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
693978001492	Active Sites [active]
693978001493	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
693978001494	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978001495	Walker A/P-loop; other site
693978001496	ATP binding site [chemical binding]; other site
693978001497	Domain of unknown function (DUF1832); Region: DUF1832; cl07463
693978001498	AAA-like domain; Region: AAA_10; pfam12846
693978001499	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978001500	Walker A motif; other site
693978001501	ATP binding site [chemical binding]; other site
693978001502	Walker B motif; other site
693978001503	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472
693978001504	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
693978001505	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693978001506	N-terminal plug; other site
693978001507	ligand-binding site [chemical binding]; other site
693978001508	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
693978001509	polyphosphate kinase; Provisional; Region: PRK05443
693978001510	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
693978001511	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
693978001512	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
693978001513	domain interface [polypeptide binding]; other site
693978001514	active site
693978001515	catalytic site [active]
693978001516	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
693978001517	putative active site [active]
693978001518	catalytic site [active]
693978001519	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
693978001520	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
693978001521	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
693978001522	amidase catalytic site [active]
693978001523	Zn binding residues [ion binding]; other site
693978001524	substrate binding site [chemical binding]; other site
693978001525	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
693978001526	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
693978001527	homodimer interface [polypeptide binding]; other site
693978001528	substrate-cofactor binding pocket; other site
693978001529	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978001530	catalytic residue [active]
693978001531	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
693978001532	Sulfatase; Region: Sulfatase; cl10460
693978001533	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
693978001534	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978001535	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
693978001536	NAD(P) binding site [chemical binding]; other site
693978001537	active site
693978001538	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
693978001539	acyl-CoA esterase; Provisional; Region: PRK10673
693978001540	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
693978001541	active site
693978001542	hydrophilic channel; other site
693978001543	dimerization interface [polypeptide binding]; other site
693978001544	catalytic residues [active]
693978001545	active site lid [active]
693978001546	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
693978001547	Mechanosensitive ion channel; Region: MS_channel; pfam00924
693978001548	Protein of unknown function (DUF456); Region: DUF456; cl01069
693978001549	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
693978001550	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
693978001551	active site
693978001552	Zn binding site [ion binding]; other site
693978001553	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693978001554	ligand binding site [chemical binding]; other site
693978001555	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978001556	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693978001557	ligand binding site [chemical binding]; other site
693978001558	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
693978001559	catalytic center binding site [active]
693978001560	ATP binding site [chemical binding]; other site
693978001561	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
693978001562	tandem repeat interface [polypeptide binding]; other site
693978001563	oligomer interface [polypeptide binding]; other site
693978001564	active site residues [active]
693978001565	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
693978001566	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
693978001567	tandem repeat interface [polypeptide binding]; other site
693978001568	oligomer interface [polypeptide binding]; other site
693978001569	active site residues [active]
693978001570	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
693978001571	dimerization interface [polypeptide binding]; other site
693978001572	putative tRNAtyr binding site [nucleotide binding]; other site
693978001573	putative active site [active]
693978001574	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
693978001575	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
693978001576	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
693978001577	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
693978001578	nucleotide binding site/active site [active]
693978001579	HIT family signature motif; other site
693978001580	catalytic residue [active]
693978001581	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
693978001582	ATP-dependent protease Clp, ATPase subunit [Posttranslational modification, protein turnover, chaperones]; Region: ClpX; COG1219
693978001583	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978001584	Walker A motif; other site
693978001585	ATP binding site [chemical binding]; other site
693978001586	Walker B motif; other site
693978001587	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
693978001588	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693978001589	catalytic residues [active]
693978001590	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
693978001591	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978001592	Walker A/P-loop; other site
693978001593	ATP binding site [chemical binding]; other site
693978001594	Q-loop/lid; other site
693978001595	ABC transporter signature motif; other site
693978001596	Walker B; other site
693978001597	D-loop; other site
693978001598	H-loop/switch region; other site
693978001599	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
693978001600	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
693978001601	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
693978001602	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
693978001603	RNA binding site [nucleotide binding]; other site
693978001604	pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212
693978001605	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
693978001606	alpha subunit interface [polypeptide binding]; other site
693978001607	TPP binding site [chemical binding]; other site
693978001608	heterodimer interface [polypeptide binding]; other site
693978001609	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
693978001610	PhoD-like phosphatase; Region: PhoD; pfam09423
693978001611	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
693978001612	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
693978001613	active site
693978001614	metal binding site [ion binding]; metal-binding site
693978001615	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978001616	glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023
693978001617	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978001618	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
693978001619	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
693978001620	active site
693978001621	ADP/pyrophosphate binding site [chemical binding]; other site
693978001622	dimerization interface [polypeptide binding]; other site
693978001623	allosteric effector site; other site
693978001624	fructose-1,6-bisphosphate binding site; other site
693978001625	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
693978001626	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
693978001627	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693978001628	N-terminal plug; other site
693978001629	ligand-binding site [chemical binding]; other site
693978001630	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978001631	trigger factor; Region: tig; TIGR00115
693978001632	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
693978001633	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
693978001634	putative active site [active]
693978001635	putative catalytic site [active]
693978001636	putative DNA binding site [nucleotide binding]; other site
693978001637	putative phosphate binding site [ion binding]; other site
693978001638	metal binding site A [ion binding]; metal-binding site
693978001639	putative AP binding site [nucleotide binding]; other site
693978001640	putative metal binding site B [ion binding]; other site
693978001641	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
693978001642	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
693978001643	FMN binding site [chemical binding]; other site
693978001644	active site
693978001645	catalytic residues [active]
693978001646	substrate binding site [chemical binding]; other site
693978001647	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
693978001648	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978001649	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978001650	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
693978001651	dimerization interface [polypeptide binding]; other site
693978001652	active site
693978001653	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
693978001654	Peptidase family M1; Region: Peptidase_M1; pfam01433
693978001655	Zn binding site [ion binding]; other site
693978001656	HEAT repeats; Region: HEAT_2; pfam13646
693978001657	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
693978001658	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978001659	CoA-ligase; Region: Ligase_CoA; cl02894
693978001660	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
693978001661	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
693978001662	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
693978001663	trimer interface [polypeptide binding]; other site
693978001664	active site
693978001665	UDP-GlcNAc binding site [chemical binding]; other site
693978001666	lipid binding site [chemical binding]; lipid-binding site
693978001667	elongation factor P; Validated; Region: PRK00529
693978001668	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
693978001669	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
693978001670	RNA binding site [nucleotide binding]; other site
693978001671	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
693978001672	RNA binding site [nucleotide binding]; other site
693978001673	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
693978001674	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
693978001675	active site
693978001676	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
693978001677	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
693978001678	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
693978001679	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
693978001680	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
693978001681	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
693978001682	trimer interface [polypeptide binding]; other site
693978001683	active site
693978001684	UDP-GlcNAc binding site [chemical binding]; other site
693978001685	lipid binding site [chemical binding]; lipid-binding site
693978001686	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
693978001687	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
693978001688	Zn2+ binding site [ion binding]; other site
693978001689	Mg2+ binding site [ion binding]; other site
693978001690	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
693978001691	active site
693978001692	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
693978001693	metal binding site [ion binding]; metal-binding site
693978001694	active site
693978001695	Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527
693978001696	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
693978001697	nucleotide binding site [chemical binding]; other site
693978001698	substrate binding site [chemical binding]; other site
693978001699	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
693978001700	putative acyl-acceptor binding pocket; other site
693978001701	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
693978001702	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
693978001703	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
693978001704	active site
693978001705	catalytic site [active]
693978001706	substrate binding site [chemical binding]; other site
693978001707	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
693978001708	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
693978001709	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
693978001710	generic binding surface II; other site
693978001711	generic binding surface I; other site
693978001712	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
693978001713	16S/18S rRNA binding site [nucleotide binding]; other site
693978001714	S13e-L30e interaction site [polypeptide binding]; other site
693978001715	25S rRNA binding site [nucleotide binding]; other site
693978001716	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
693978001717	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
693978001718	RNase E interface [polypeptide binding]; other site
693978001719	trimer interface [polypeptide binding]; other site
693978001720	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
693978001721	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
693978001722	RNase E interface [polypeptide binding]; other site
693978001723	trimer interface [polypeptide binding]; other site
693978001724	active site
693978001725	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
693978001726	putative nucleic acid binding region [nucleotide binding]; other site
693978001727	G-X-X-G motif; other site
693978001728	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
693978001729	RNA binding site [nucleotide binding]; other site
693978001730	domain interface; other site
693978001731	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
693978001732	malate dehydrogenase; Reviewed; Region: PRK06223
693978001733	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
693978001734	dimer interface [polypeptide binding]; other site
693978001735	NAD(P) binding site [chemical binding]; other site
693978001736	tetramer (dimer of dimers) interface [polypeptide binding]; other site
693978001737	substrate binding site [chemical binding]; other site
693978001738	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
693978001739	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693978001740	ATP binding site [chemical binding]; other site
693978001741	putative Mg++ binding site [ion binding]; other site
693978001742	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693978001743	nucleotide binding region [chemical binding]; other site
693978001744	ATP-binding site [chemical binding]; other site
693978001745	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
693978001746	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
693978001747	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
693978001748	putative active site [active]
693978001749	substrate binding site [chemical binding]; other site
693978001750	putative cosubstrate binding site; other site
693978001751	catalytic site [active]
693978001752	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
693978001753	substrate binding site [chemical binding]; other site
693978001754	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
693978001755	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
693978001756	dimer interface [polypeptide binding]; other site
693978001757	active site
693978001758	aspartate-rich active site metal binding site; other site
693978001759	allosteric magnesium binding site [ion binding]; other site
693978001760	Schiff base residues; other site
693978001761	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978001762	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
693978001763	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
693978001764	RimM N-terminal domain; Region: RimM; pfam01782
693978001765	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
693978001766	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
693978001767	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
693978001768	Bacterial sugar transferase; Region: Bac_transf; cl00939
693978001769	Permease; Region: Permease; cl00510
693978001770	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
693978001771	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978001772	Walker A/P-loop; other site
693978001773	ATP binding site [chemical binding]; other site
693978001774	Q-loop/lid; other site
693978001775	ABC transporter signature motif; other site
693978001776	Walker B; other site
693978001777	D-loop; other site
693978001778	H-loop/switch region; other site
693978001779	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978001780	Peptidase family M48; Region: Peptidase_M48; cl12018
693978001781	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
693978001782	AMP-binding enzyme; Region: AMP-binding; cl15778
693978001783	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
693978001784	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
693978001785	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
693978001786	putative metal binding site [ion binding]; other site
693978001787	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
693978001788	ATP-grasp domain; Region: ATP-grasp_4; cl03087
693978001789	AIR carboxylase; Region: AIRC; cl00310
693978001790	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
693978001791	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
693978001792	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
693978001793	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
693978001794	active site
693978001795	HIGH motif; other site
693978001796	dimer interface [polypeptide binding]; other site
693978001797	KMSKS motif; other site
693978001798	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
693978001799	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978001800	Protein of unknown function (DUF541); Region: SIMPL; cl01077
693978001801	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
693978001802	RNA/DNA hybrid binding site [nucleotide binding]; other site
693978001803	active site
693978001804	replicative DNA helicase; Region: DnaB; TIGR00665
693978001805	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
693978001806	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
693978001807	Walker A motif; other site
693978001808	ATP binding site [chemical binding]; other site
693978001809	Walker B motif; other site
693978001810	DNA binding loops [nucleotide binding]
693978001811	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
693978001812	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
693978001813	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
693978001814	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
693978001815	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
693978001816	dimer interface [polypeptide binding]; other site
693978001817	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
693978001818	active site
693978001819	Fe binding site [ion binding]; other site
693978001820	fumarylacetoacetase; Region: PLN02856
693978001821	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
693978001822	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
693978001823	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
693978001824	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
693978001825	glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378
693978001826	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
693978001827	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
693978001828	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
693978001829	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
693978001830	This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity.  In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs.  Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269
693978001831	Walker A/P-loop; other site
693978001832	ATP binding site [chemical binding]; other site
693978001833	Q-loop/lid; other site
693978001834	ABC transporter signature motif; other site
693978001835	Walker B; other site
693978001836	D-loop; other site
693978001837	H-loop/switch region; other site
693978001838	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
693978001839	chaperone protein DnaJ; Provisional; Region: PRK14289
693978001840	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
693978001841	HSP70 interaction site [polypeptide binding]; other site
693978001842	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
693978001843	Zn binding sites [ion binding]; other site
693978001844	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
693978001845	dimer interface [polypeptide binding]; other site
693978001846	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
693978001847	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
693978001848	dimer interface [polypeptide binding]; other site
693978001849	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
693978001850	manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845
693978001851	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
693978001852	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978001853	prolyl-tRNA synthetase; Provisional; Region: PRK08661
693978001854	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778
693978001855	dimer interface [polypeptide binding]; other site
693978001856	motif 1; other site
693978001857	active site
693978001858	motif 2; other site
693978001859	motif 3; other site
693978001860	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
693978001861	anticodon binding site; other site
693978001862	zinc-binding site [ion binding]; other site
693978001863	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
693978001864	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
693978001865	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
693978001866	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
693978001867	substrate binding site [chemical binding]; other site
693978001868	hexamer interface [polypeptide binding]; other site
693978001869	metal binding site [ion binding]; metal-binding site
693978001870	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
693978001871	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
693978001872	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693978001873	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
693978001874	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693978001875	DNA binding residues [nucleotide binding]
693978001876	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
693978001877	catalytic residues [active]
693978001878	dimer interface [polypeptide binding]; other site
693978001879	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
693978001880	Ligand binding site; other site
693978001881	oligomer interface; other site
693978001882	Bacterial SH3 domain; Region: SH3_3; cl02551
693978001883	aspartate aminotransferase; Provisional; Region: PRK05764
693978001884	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
693978001885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978001886	homodimer interface [polypeptide binding]; other site
693978001887	catalytic residue [active]
693978001888	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
693978001889	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
693978001890	active site
693978001891	substrate binding site [chemical binding]; other site
693978001892	metal binding site [ion binding]; metal-binding site
693978001893	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
693978001894	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
693978001895	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
693978001896	Ligand binding site; other site
693978001897	Putative Catalytic site; other site
693978001898	DXD motif; other site
693978001899	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
693978001900	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
693978001901	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693978001902	active site
693978001903	HIGH motif; other site
693978001904	nucleotide binding site [chemical binding]; other site
693978001905	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
693978001906	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
693978001907	active site
693978001908	KMSKS motif; other site
693978001909	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
693978001910	tRNA binding surface [nucleotide binding]; other site
693978001911	anticodon binding site; other site
693978001912	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
693978001913	Protein of unknown function (DUF4241); Region: DUF4241; pfam14025
693978001914	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
693978001915	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
693978001916	dimer interface [polypeptide binding]; other site
693978001917	substrate binding site [chemical binding]; other site
693978001918	ATP binding site [chemical binding]; other site
693978001919	AMP-binding enzyme; Region: AMP-binding; cl15778
693978001920	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
693978001921	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693978001922	acetyl-CoA C-acetyltransferase; Region: PLN02644
693978001923	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
693978001924	dimer interface [polypeptide binding]; other site
693978001925	active site
693978001926	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
693978001927	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
693978001928	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
693978001929	active site
693978001930	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
693978001931	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
693978001932	Glutamate binding site [chemical binding]; other site
693978001933	NAD binding site [chemical binding]; other site
693978001934	catalytic residues [active]
693978001935	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693978001936	S-adenosylmethionine binding site [chemical binding]; other site
693978001937	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
693978001938	AMP-binding enzyme; Region: AMP-binding; cl15778
693978001939	2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633
693978001940	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
693978001941	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
693978001942	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
693978001943	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
693978001944	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
693978001945	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
693978001946	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
693978001947	ABC transporter; Region: ABC_tran_2; pfam12848
693978001948	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
693978001949	Mnd1 family; Region: Mnd1; pfam03962
693978001950	glycine dehydrogenase; Provisional; Region: PRK05367
693978001951	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
693978001952	tetramer interface [polypeptide binding]; other site
693978001953	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978001954	catalytic residue [active]
693978001955	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
693978001956	tetramer interface [polypeptide binding]; other site
693978001957	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978001958	catalytic residue [active]
693978001959	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
693978001960	HSP70 interaction site [polypeptide binding]; other site
693978001961	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
693978001962	NADH(P)-binding; Region: NAD_binding_10; pfam13460
693978001963	NAD binding site [chemical binding]; other site
693978001964	active site
693978001965	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
693978001966	dimer interface [polypeptide binding]; other site
693978001967	catalytic triad [active]
693978001968	peroxidatic and resolving cysteines [active]
693978001969	NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007
693978001970	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
693978001971	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
693978001972	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
693978001973	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
693978001974	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
693978001975	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
693978001976	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
693978001977	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
693978001978	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
693978001979	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
693978001980	4Fe-4S binding domain; Region: Fer4; cl02805
693978001981	4Fe-4S binding domain; Region: Fer4; cl02805
693978001982	NADH dehydrogenase; Region: NADHdh; cl00469
693978001983	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
693978001984	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
693978001985	catalytic loop [active]
693978001986	iron binding site [ion binding]; other site
693978001987	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
693978001988	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
693978001989	SLBB domain; Region: SLBB; pfam10531
693978001990	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
693978001991	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
693978001992	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
693978001993	putative dimer interface [polypeptide binding]; other site
693978001994	[2Fe-2S] cluster binding site [ion binding]; other site
693978001995	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
693978001996	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
693978001997	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
693978001998	NADH dehydrogenase subunit B; Provisional; Region: PRK14820
693978001999	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
693978002000	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
693978002001	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
693978002002	Coenzyme A binding pocket [chemical binding]; other site
693978002003	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049
693978002004	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
693978002005	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
693978002006	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978002007	TIGR01777 family protein; Region: yfcH
693978002008	NAD(P) binding site [chemical binding]; other site
693978002009	active site
693978002010	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
693978002011	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
693978002012	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
693978002013	Repair protein; Region: Repair_PSII; cl01535
693978002014	Repair protein; Region: Repair_PSII; cl01535
693978002015	LemA family; Region: LemA; cl00742
693978002016	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
693978002017	folate binding site [chemical binding]; other site
693978002018	NADP+ binding site [chemical binding]; other site
693978002019	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
693978002020	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
693978002021	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693978002022	FeS/SAM binding site; other site
693978002023	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
693978002024	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
693978002025	substrate binding site; other site
693978002026	tetramer interface; other site
693978002027	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
693978002028	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
693978002029	NAD binding site [chemical binding]; other site
693978002030	substrate binding site [chemical binding]; other site
693978002031	homodimer interface [polypeptide binding]; other site
693978002032	active site
693978002033	Cupin domain; Region: Cupin_2; cl09118
693978002034	Bacterial sugar transferase; Region: Bac_transf; cl00939
693978002035	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
693978002036	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
693978002037	inhibitor-cofactor binding pocket; inhibition site
693978002038	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978002039	catalytic residue [active]
693978002040	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
693978002041	classical (c) SDRs; Region: SDR_c; cd05233
693978002042	NAD(P) binding site [chemical binding]; other site
693978002043	active site
693978002044	Phosphopantetheine attachment site; Region: PP-binding; cl09936
693978002045	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
693978002046	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
693978002047	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
693978002048	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
693978002049	dimer interface [polypeptide binding]; other site
693978002050	substrate binding site [chemical binding]; other site
693978002051	metal binding site [ion binding]; metal-binding site
693978002052	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
693978002053	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
693978002054	dimer interface [polypeptide binding]; other site
693978002055	active site
693978002056	CoA binding pocket [chemical binding]; other site
693978002057	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
693978002058	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
693978002059	putative trimer interface [polypeptide binding]; other site
693978002060	putative CoA binding site [chemical binding]; other site
693978002061	Bacterial sugar transferase; Region: Bac_transf; cl00939
693978002062	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
693978002063	putative ADP-binding pocket [chemical binding]; other site
693978002064	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
693978002065	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
693978002066	active site
693978002067	dimer interface [polypeptide binding]; other site
693978002068	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
693978002069	Ligand Binding Site [chemical binding]; other site
693978002070	Molecular Tunnel; other site
693978002071	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693978002072	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
693978002073	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693978002074	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
693978002075	Probable Catalytic site; other site
693978002076	twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808
693978002077	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
693978002078	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
693978002079	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978002080	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
693978002081	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978002082	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
693978002083	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
693978002084	NAD binding site [chemical binding]; other site
693978002085	substrate binding site [chemical binding]; other site
693978002086	homodimer interface [polypeptide binding]; other site
693978002087	active site
693978002088	tyrosine kinase; Provisional; Region: PRK11519
693978002089	Chain length determinant protein; Region: Wzz; cl15801
693978002090	Chain length determinant protein; Region: Wzz; cl15801
693978002091	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978002092	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
693978002093	SLBB domain; Region: SLBB; pfam10531
693978002094	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
693978002095	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
693978002096	NAD(P) binding site [chemical binding]; other site
693978002097	homodimer interface [polypeptide binding]; other site
693978002098	substrate binding site [chemical binding]; other site
693978002099	active site
693978002100	RecX family; Region: RecX; cl00936
693978002101	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
693978002102	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
693978002103	dimer interface [polypeptide binding]; other site
693978002104	active site
693978002105	glycine-pyridoxal phosphate binding site [chemical binding]; other site
693978002106	folate binding site [chemical binding]; other site
693978002107	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
693978002108	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
693978002109	active site
693978002110	dimer interface [polypeptide binding]; other site
693978002111	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
693978002112	dimer interface [polypeptide binding]; other site
693978002113	active site
693978002114	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185
693978002115	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
693978002116	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
693978002117	homodimer interface [polypeptide binding]; other site
693978002118	NADP binding site [chemical binding]; other site
693978002119	substrate binding site [chemical binding]; other site
693978002120	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
693978002121	ligand binding site [chemical binding]; other site
693978002122	flexible hinge region; other site
693978002123	Helix-turn-helix domains; Region: HTH; cl00088
693978002124	chaperone protein HchA; Provisional; Region: PRK04155
693978002125	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
693978002126	conserved cys residue [active]
693978002127	short chain dehydrogenase; Provisional; Region: PRK06179
693978002128	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
693978002129	NADP binding site [chemical binding]; other site
693978002130	active site
693978002131	steroid binding site; other site
693978002132	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
693978002133	hinge; other site
693978002134	active site
693978002135	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
693978002136	homodimer interface [polypeptide binding]; other site
693978002137	metal binding site [ion binding]; metal-binding site
693978002138	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
693978002139	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
693978002140	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
693978002141	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
693978002142	putative trimer interface [polypeptide binding]; other site
693978002143	putative CoA binding site [chemical binding]; other site
693978002144	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
693978002145	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
693978002146	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693978002147	FeS/SAM binding site; other site
693978002148	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
693978002149	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
693978002150	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
693978002151	active site
693978002152	HIGH motif; other site
693978002153	KMSK motif region; other site
693978002154	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
693978002155	tRNA binding surface [nucleotide binding]; other site
693978002156	anticodon binding site; other site
693978002157	starch binding outer membrane protein SusD; Region: SusD; cl15876
693978002158	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693978002159	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
693978002160	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978002161	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
693978002162	RNA/DNA hybrid binding site [nucleotide binding]; other site
693978002163	active site
693978002164	membrane protein insertase; Provisional; Region: PRK01318
693978002165	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
693978002166	CTP synthetase; Validated; Region: pyrG; PRK05380
693978002167	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
693978002168	Catalytic site [active]
693978002169	active site
693978002170	UTP binding site [chemical binding]; other site
693978002171	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
693978002172	active site
693978002173	putative oxyanion hole; other site
693978002174	catalytic triad [active]
693978002175	protein RecA; Region: tigrfam_recA; TIGR02012
693978002176	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
693978002177	hexamer interface [polypeptide binding]; other site
693978002178	Walker A motif; other site
693978002179	ATP binding site [chemical binding]; other site
693978002180	Walker B motif; other site
693978002181	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
693978002182	active site
693978002183	DNA polymerase IV; Validated; Region: PRK02406
693978002184	DNA binding site [nucleotide binding]
693978002185	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
693978002186	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
693978002187	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
693978002188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978002189	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
693978002190	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
693978002191	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
693978002192	putative Iron-sulfur protein interface [polypeptide binding]; other site
693978002193	proximal heme binding site [chemical binding]; other site
693978002194	distal heme binding site [chemical binding]; other site
693978002195	putative dimer interface [polypeptide binding]; other site
693978002196	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
693978002197	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
693978002198	Competence protein; Region: Competence; cl00471
693978002199	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
693978002200	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
693978002201	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
693978002202	putative catalytic site [active]
693978002203	putative metal binding site [ion binding]; other site
693978002204	putative phosphate binding site [ion binding]; other site
693978002205	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
693978002206	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
693978002207	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
693978002208	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
693978002209	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
693978002210	FMN binding site [chemical binding]; other site
693978002211	substrate binding site [chemical binding]; other site
693978002212	putative catalytic residue [active]
693978002213	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
693978002214	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
693978002215	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
693978002216	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
693978002217	Protein of unknown function (DUF2480); Region: DUF2480; pfam10652
693978002218	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
693978002219	Deoxyhypusine synthase; Region: DS; cl00826
693978002220	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
693978002221	exosortase F-associated protein; Region: flavo_near_exo; TIGR04127
693978002222	NifU-like domain; Region: NifU; cl00484
693978002223	Domain of unknown function DUF59; Region: DUF59; cl00941
693978002224	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
693978002225	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
693978002226	Walker A motif; other site
693978002227	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
693978002228	Bacterial SH3 domain; Region: SH3_3; cl02551
693978002229	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
693978002230	BON domain; Region: BON; cl02771
693978002231	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
693978002232	active site
693978002233	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
693978002234	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693978002235	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
693978002236	N-terminal plug; other site
693978002237	ligand-binding site [chemical binding]; other site
693978002238	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
693978002239	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693978002240	catalytic residues [active]
693978002241	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978002242	Haem-binding domain; Region: Haem_bd; pfam14376
693978002243	Bacterial Ig-like domain; Region: Big_5; cl01012
693978002244	DNA repair protein RadA; Provisional; Region: PRK11823
693978002245	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
693978002246	Walker A motif/ATP binding site; other site
693978002247	ATP binding site [chemical binding]; other site
693978002248	Walker B motif; other site
693978002249	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
693978002250	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
693978002251	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
693978002252	substrate binding site [chemical binding]; other site
693978002253	oxyanion hole (OAH) forming residues; other site
693978002254	trimer interface [polypeptide binding]; other site
693978002255	Protein of unknown function DUF72; Region: DUF72; cl00777
693978002256	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
693978002257	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
693978002258	Class I ribonucleotide reductase; Region: RNR_I; cd01679
693978002259	active site
693978002260	dimer interface [polypeptide binding]; other site
693978002261	catalytic residues [active]
693978002262	effector binding site; other site
693978002263	R2 peptide binding site; other site
693978002264	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
693978002265	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
693978002266	dimer interface [polypeptide binding]; other site
693978002267	putative radical transfer pathway; other site
693978002268	diiron center [ion binding]; other site
693978002269	tyrosyl radical; other site
693978002270	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
693978002271	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693978002272	active site
693978002273	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
693978002274	Zn2+ binding site [ion binding]; other site
693978002275	Mg2+ binding site [ion binding]; other site
693978002276	glutamate dehydrogenase; Provisional; Region: PRK09414
693978002277	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
693978002278	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
693978002279	NAD(P) binding site [chemical binding]; other site
693978002280	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
693978002281	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
693978002282	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
693978002283	heme-binding site [chemical binding]; other site
693978002284	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
693978002285	active site
693978002286	putative DNA-binding cleft [nucleotide binding]; other site
693978002287	dimer interface [polypeptide binding]; other site
693978002288	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
693978002289	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
693978002290	Helix-turn-helix domains; Region: HTH; cl00088
693978002291	AsnC family; Region: AsnC_trans_reg; pfam01037
693978002292	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693978002293	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
693978002294	starch binding outer membrane protein SusD; Region: SusD; cd08977
693978002295	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
693978002296	RuvA N terminal domain; Region: RuvA_N; pfam01330
693978002297	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
693978002298	cell surface protein SprA; Region: surface_SprA; TIGR04189
693978002299	Motility related/secretion protein; Region: SprA_N; pfam14349
693978002300	Motility related/secretion protein; Region: SprA_N; pfam14349
693978002301	Motility related/secretion protein; Region: SprA_N; pfam14349
693978002302	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
693978002303	active site
693978002304	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
693978002305	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
693978002306	putative active site [active]
693978002307	putative metal binding site [ion binding]; other site
693978002308	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
693978002309	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
693978002310	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
693978002311	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
693978002312	catalytic triad [active]
693978002313	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
693978002314	endonuclease III; Region: ENDO3c; smart00478
693978002315	minor groove reading motif; other site
693978002316	helix-hairpin-helix signature motif; other site
693978002317	substrate binding pocket [chemical binding]; other site
693978002318	active site
693978002319	elongation factor Ts; Provisional; Region: tsf; PRK09377
693978002320	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
693978002321	Elongation factor TS; Region: EF_TS; pfam00889
693978002322	Elongation factor TS; Region: EF_TS; pfam00889
693978002323	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
693978002324	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
693978002325	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
693978002326	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
693978002327	HIGH motif; other site
693978002328	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
693978002329	active site
693978002330	KMSKS motif; other site
693978002331	GH3 auxin-responsive promoter; Region: GH3; cl04006
693978002332	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
693978002333	Clp amino terminal domain; Region: Clp_N; pfam02861
693978002334	Clp amino terminal domain; Region: Clp_N; pfam02861
693978002335	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978002336	Walker A motif; other site
693978002337	ATP binding site [chemical binding]; other site
693978002338	Walker B motif; other site
693978002339	arginine finger; other site
693978002340	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978002341	Walker A motif; other site
693978002342	ATP binding site [chemical binding]; other site
693978002343	Walker B motif; other site
693978002344	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
693978002345	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
693978002346	putative active site [active]
693978002347	catalytic residue [active]
693978002348	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
693978002349	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978002350	OpgC protein; Region: OpgC_C; cl00792
693978002351	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
693978002352	Sulfate transporter family; Region: Sulfate_transp; cl15842
693978002353	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
693978002354	active site clefts [active]
693978002355	zinc binding site [ion binding]; other site
693978002356	dimer interface [polypeptide binding]; other site
693978002357	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
693978002358	trimer interface [polypeptide binding]; other site
693978002359	active site
693978002360	substrate binding site [chemical binding]; other site
693978002361	CoA binding site [chemical binding]; other site
693978002362	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693978002363	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
693978002364	putative ADP-binding pocket [chemical binding]; other site
693978002365	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
693978002366	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693978002367	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693978002368	active site
693978002369	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693978002370	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
693978002371	putative ADP-binding pocket [chemical binding]; other site
693978002372	dihydroorotase; Reviewed; Region: PRK09236
693978002373	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
693978002374	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
693978002375	active site
693978002376	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693978002377	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
693978002378	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693978002379	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693978002380	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
693978002381	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693978002382	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
693978002383	short chain dehydrogenase; Provisional; Region: PRK07677
693978002384	NAD(P) binding site [chemical binding]; other site
693978002385	substrate binding site [chemical binding]; other site
693978002386	homotetramer interface [polypeptide binding]; other site
693978002387	active site
693978002388	homodimer interface [polypeptide binding]; other site
693978002389	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
693978002390	DHH family; Region: DHH; pfam01368
693978002391	DHHA1 domain; Region: DHHA1; pfam02272
693978002392	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
693978002393	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
693978002394	active site
693978002395	(T/H)XGH motif; other site
693978002396	Domain of unknown function (DUF3817); Region: DUF3817; cl14844
693978002397	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
693978002398	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
693978002399	active site
693978002400	metal binding site [ion binding]; metal-binding site
693978002401	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
693978002402	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
693978002403	homotrimer interaction site [polypeptide binding]; other site
693978002404	putative active site [active]
693978002405	enolase; Provisional; Region: eno; PRK00077
693978002406	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
693978002407	dimer interface [polypeptide binding]; other site
693978002408	metal binding site [ion binding]; metal-binding site
693978002409	substrate binding pocket [chemical binding]; other site
693978002410	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
693978002411	dimer interface [polypeptide binding]; other site
693978002412	Citrate synthase; Region: Citrate_synt; pfam00285
693978002413	active site
693978002414	citrylCoA binding site [chemical binding]; other site
693978002415	NADH binding [chemical binding]; other site
693978002416	cationic pore residues; other site
693978002417	oxalacetate/citrate binding site [chemical binding]; other site
693978002418	coenzyme A binding site [chemical binding]; other site
693978002419	catalytic triad [active]
693978002420	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
693978002421	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693978002422	catalytic residues [active]
693978002423	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
693978002424	Amidinotransferase; Region: Amidinotransf; cl12043
693978002425	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
693978002426	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
693978002427	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
693978002428	alphaNTD - beta interaction site [polypeptide binding]; other site
693978002429	alphaNTD homodimer interface [polypeptide binding]; other site
693978002430	alphaNTD - beta' interaction site [polypeptide binding]; other site
693978002431	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
693978002432	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
693978002433	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
693978002434	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
693978002435	RNA binding surface [nucleotide binding]; other site
693978002436	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
693978002437	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
693978002438	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
693978002439	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
693978002440	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
693978002441	rRNA binding site [nucleotide binding]; other site
693978002442	predicted 30S ribosome binding site; other site
693978002443	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
693978002444	SecY translocase; Region: SecY; pfam00344
693978002445	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
693978002446	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
693978002447	23S rRNA binding site [nucleotide binding]; other site
693978002448	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
693978002449	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
693978002450	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
693978002451	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
693978002452	5S rRNA interface [nucleotide binding]; other site
693978002453	L27 interface [polypeptide binding]; other site
693978002454	23S rRNA interface [nucleotide binding]; other site
693978002455	L5 interface [polypeptide binding]; other site
693978002456	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
693978002457	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
693978002458	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
693978002459	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
693978002460	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
693978002461	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
693978002462	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
693978002463	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
693978002464	KOW motif; Region: KOW; cl00354
693978002465	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
693978002466	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
693978002467	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
693978002468	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
693978002469	23S rRNA interface [nucleotide binding]; other site
693978002470	putative translocon interaction site; other site
693978002471	signal recognition particle (SRP54) interaction site; other site
693978002472	L23 interface [polypeptide binding]; other site
693978002473	trigger factor interaction site; other site
693978002474	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
693978002475	23S rRNA interface [nucleotide binding]; other site
693978002476	5S rRNA interface [nucleotide binding]; other site
693978002477	putative antibiotic binding site [chemical binding]; other site
693978002478	L25 interface [polypeptide binding]; other site
693978002479	L27 interface [polypeptide binding]; other site
693978002480	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
693978002481	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
693978002482	G-X-X-G motif; other site
693978002483	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
693978002484	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
693978002485	putative translocon binding site; other site
693978002486	protein-rRNA interface [nucleotide binding]; other site
693978002487	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
693978002488	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
693978002489	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
693978002490	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
693978002491	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
693978002492	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
693978002493	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
693978002494	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978002495	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
693978002496	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
693978002497	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
693978002498	Maf-like protein; Region: Maf; pfam02545
693978002499	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
693978002500	active site
693978002501	dimer interface [polypeptide binding]; other site
693978002502	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
693978002503	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
693978002504	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
693978002505	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
693978002506	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978002507	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
693978002508	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
693978002509	UreD urease accessory protein; Region: UreD; cl00530
693978002510	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
693978002511	G1 box; other site
693978002512	GTP/Mg2+ binding site [chemical binding]; other site
693978002513	G2 box; other site
693978002514	Switch I region; other site
693978002515	G3 box; other site
693978002516	Switch II region; other site
693978002517	G4 box; other site
693978002518	G5 box; other site
693978002519	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
693978002520	UreF; Region: UreF; pfam01730
693978002521	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
693978002522	dimer interface [polypeptide binding]; other site
693978002523	catalytic residues [active]
693978002524	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
693978002525	subunit interactions [polypeptide binding]; other site
693978002526	urease subunit alpha; Reviewed; Region: ureC; PRK13207
693978002527	active site
693978002528	flap region; other site
693978002529	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
693978002530	gamma-beta subunit interface [polypeptide binding]; other site
693978002531	alpha-beta subunit interface [polypeptide binding]; other site
693978002532	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
693978002533	alpha-gamma subunit interface [polypeptide binding]; other site
693978002534	beta-gamma subunit interface [polypeptide binding]; other site
693978002535	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
693978002536	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
693978002537	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693978002538	N-terminal plug; other site
693978002539	ligand-binding site [chemical binding]; other site
693978002540	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
693978002541	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
693978002542	Walker A/P-loop; other site
693978002543	ATP binding site [chemical binding]; other site
693978002544	Q-loop/lid; other site
693978002545	ABC transporter signature motif; other site
693978002546	Walker B; other site
693978002547	D-loop; other site
693978002548	H-loop/switch region; other site
693978002549	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
693978002550	ABC-ATPase subunit  interface; other site
693978002551	dimer interface [polypeptide binding]; other site
693978002552	putative PBP binding regions; other site
693978002553	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
693978002554	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
693978002555	intersubunit interface [polypeptide binding]; other site
693978002556	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
693978002557	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
693978002558	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
693978002559	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
693978002560	active site
693978002561	intersubunit interface [polypeptide binding]; other site
693978002562	zinc binding site [ion binding]; other site
693978002563	Na+ binding site [ion binding]; other site
693978002564	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
693978002565	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
693978002566	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
693978002567	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
693978002568	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978002569	flavoprotein, HI0933 family; Region: TIGR00275
693978002570	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
693978002571	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
693978002572	ResB-like family; Region: ResB; pfam05140
693978002573	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
693978002574	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
693978002575	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
693978002576	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
693978002577	active site
693978002578	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
693978002579	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978002580	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
693978002581	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
693978002582	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978002583	Walker A/P-loop; other site
693978002584	ATP binding site [chemical binding]; other site
693978002585	Q-loop/lid; other site
693978002586	ABC transporter signature motif; other site
693978002587	Walker B; other site
693978002588	D-loop; other site
693978002589	H-loop/switch region; other site
693978002590	Protein of unknown function (DUF3276); Region: DUF3276; cl15305
693978002591	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
693978002592	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
693978002593	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693978002594	binding surface
693978002595	TPR motif; other site
693978002596	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
693978002597	Gram-negative bacterial tonB protein; Region: TonB; cl10048
693978002598	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
693978002599	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
693978002600	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
693978002601	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693978002602	active site
693978002603	HIGH motif; other site
693978002604	nucleotide binding site [chemical binding]; other site
693978002605	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693978002606	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
693978002607	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693978002608	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693978002609	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693978002610	active site
693978002611	KMSKS motif; other site
693978002612	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
693978002613	tRNA binding surface [nucleotide binding]; other site
693978002614	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
693978002615	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693978002616	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693978002617	active site
693978002618	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
693978002619	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
693978002620	protein binding site [polypeptide binding]; other site
693978002621	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
693978002622	protein binding site [polypeptide binding]; other site
693978002623	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
693978002624	Peptidase family U32; Region: Peptidase_U32; cl03113
693978002625	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
693978002626	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
693978002627	seryl-tRNA synthetase; Provisional; Region: PRK05431
693978002628	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
693978002629	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
693978002630	dimer interface [polypeptide binding]; other site
693978002631	active site
693978002632	motif 1; other site
693978002633	motif 2; other site
693978002634	motif 3; other site
693978002635	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
693978002636	Ligand Binding Site [chemical binding]; other site
693978002637	B3/4 domain; Region: B3_4; cl11458
693978002638	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
693978002639	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
693978002640	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
693978002641	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
693978002642	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
693978002643	nucleophilic elbow; other site
693978002644	catalytic triad; other site
693978002645	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
693978002646	Family description; Region: VCBS; pfam13517
693978002647	Family description; Region: VCBS; pfam13517
693978002648	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
693978002649	RHS Repeat; Region: RHS_repeat; cl11982
693978002650	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
693978002651	Serum amyloid A protein; Region: SAA; cl02506
693978002652	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
693978002653	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
693978002654	NAD(P) binding site [chemical binding]; other site
693978002655	catalytic residues [active]
693978002656	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
693978002657	pyruvate kinase; Provisional; Region: PRK05826
693978002658	active site
693978002659	domain interfaces; other site
693978002660	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
693978002661	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
693978002662	dimerization interface [polypeptide binding]; other site
693978002663	active site
693978002664	metal binding site [ion binding]; metal-binding site
693978002665	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054
693978002666	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
693978002667	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
693978002668	dimer interface [polypeptide binding]; other site
693978002669	active site
693978002670	Phosphopantetheine attachment site; Region: PP-binding; cl09936
693978002671	Cysteine-rich domain; Region: CCG; pfam02754
693978002672	Cysteine-rich domain; Region: CCG; pfam02754
693978002673	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
693978002674	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
693978002675	mce related protein; Region: MCE; pfam02470
693978002676	SurA N-terminal domain; Region: SurA_N_3; cl07813
693978002677	PPIC-type PPIASE domain; Region: Rotamase; cl08278
693978002678	PPIC-type PPIASE domain; Region: Rotamase; cl08278
693978002679	periplasmic folding chaperone; Provisional; Region: PRK10788
693978002680	Cupin domain; Region: Cupin_2; cl09118
693978002681	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
693978002682	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693978002683	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
693978002684	The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693
693978002685	ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885
693978002686	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
693978002687	inhibitor-cofactor binding pocket; inhibition site
693978002688	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978002689	catalytic residue [active]
693978002690	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
693978002691	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
693978002692	ATP-grasp domain; Region: ATP-grasp_4; cl03087
693978002693	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
693978002694	acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531
693978002695	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
693978002696	carboxyltransferase (CT) interaction site; other site
693978002697	biotinylation site [posttranslational modification]; other site
693978002698	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
693978002699	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
693978002700	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
693978002701	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
693978002702	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
693978002703	Lumazine binding domain; Region: Lum_binding; pfam00677
693978002704	Lumazine binding domain; Region: Lum_binding; pfam00677
693978002705	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693978002706	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
693978002707	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
693978002708	dimer interface [polypeptide binding]; other site
693978002709	phosphorylation site [posttranslational modification]
693978002710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693978002711	ATP binding site [chemical binding]; other site
693978002712	Mg2+ binding site [ion binding]; other site
693978002713	G-X-G motif; other site
693978002714	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
693978002715	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693978002716	S-adenosylmethionine binding site [chemical binding]; other site
693978002717	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
693978002718	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
693978002719	Walker A/P-loop; other site
693978002720	ATP binding site [chemical binding]; other site
693978002721	Q-loop/lid; other site
693978002722	ABC transporter signature motif; other site
693978002723	Walker B; other site
693978002724	D-loop; other site
693978002725	H-loop/switch region; other site
693978002726	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
693978002727	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
693978002728	DHH family; Region: DHH; pfam01368
693978002729	DHHA1 domain; Region: DHHA1; pfam02272
693978002730	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
693978002731	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978002732	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693978002733	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978002734	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978002735	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
693978002736	starch binding outer membrane protein SusD; Region: SusD; cd08977
693978002737	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
693978002738	putative active site [active]
693978002739	putative metal binding site [ion binding]; other site
693978002740	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
693978002741	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
693978002742	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693978002743	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
693978002744	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
693978002745	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
693978002746	Helix-turn-helix domains; Region: HTH; cl00088
693978002747	Amidinotransferase; Region: Amidinotransf; cl12043
693978002748	diaminopimelate decarboxylase; Region: lysA; TIGR01048
693978002749	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
693978002750	active site
693978002751	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
693978002752	substrate binding site [chemical binding]; other site
693978002753	catalytic residues [active]
693978002754	dimer interface [polypeptide binding]; other site
693978002755	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
693978002756	peptide chain release factor 1; Validated; Region: prfA; PRK00591
693978002757	RF-1 domain; Region: RF-1; cl02875
693978002758	RF-1 domain; Region: RF-1; cl02875
693978002759	OsmC-like protein; Region: OsmC; cl00767
693978002760	Transcriptional regulator; Region: Transcrip_reg; cl00361
693978002761	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978002762	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693978002763	ligand binding site [chemical binding]; other site
693978002764	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
693978002765	SmpB-tmRNA interface; other site
693978002766	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
693978002767	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978002768	Walker A/P-loop; other site
693978002769	ATP binding site [chemical binding]; other site
693978002770	Q-loop/lid; other site
693978002771	ABC transporter signature motif; other site
693978002772	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
693978002773	Walker B; other site
693978002774	D-loop; other site
693978002775	H-loop/switch region; other site
693978002776	ABC transporter; Region: ABC_tran_2; pfam12848
693978002777	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
693978002778	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
693978002779	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
693978002780	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
693978002781	Family of unknown function (DUF490); Region: DUF490; pfam04357
693978002782	Surface antigen; Region: Bac_surface_Ag; cl03097
693978002783	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
693978002784	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
693978002785	human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; Region: 17beta-HSDXI-like_SDR_c; cd05339
693978002786	putative NAD(P) binding site [chemical binding]; other site
693978002787	homodimer interface [polypeptide binding]; other site
693978002788	active site
693978002789	substrate binding site [chemical binding]; other site
693978002790	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
693978002791	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
693978002792	NAD(P) binding site [chemical binding]; other site
693978002793	catalytic residues [active]
693978002794	cell division protein FtsZ; Validated; Region: PRK09330
693978002795	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
693978002796	nucleotide binding site [chemical binding]; other site
693978002797	SulA interaction site; other site
693978002798	cell division protein FtsA; Region: ftsA; TIGR01174
693978002799	Cell division protein FtsA; Region: FtsA; cl11496
693978002800	Cell division protein FtsA; Region: FtsA; cl11496
693978002801	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
693978002802	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
693978002803	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
693978002804	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
693978002805	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
693978002806	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
693978002807	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
693978002808	active site
693978002809	homodimer interface [polypeptide binding]; other site
693978002810	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
693978002811	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
693978002812	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978002813	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
693978002814	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
693978002815	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
693978002816	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
693978002817	Mg++ binding site [ion binding]; other site
693978002818	putative catalytic motif [active]
693978002819	putative substrate binding site [chemical binding]; other site
693978002820	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
693978002821	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
693978002822	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
693978002823	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
693978002824	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
693978002825	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
693978002826	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
693978002827	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
693978002828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
693978002829	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
693978002830	cell division protein MraZ; Reviewed; Region: PRK00326
693978002831	MraZ protein; Region: MraZ; pfam02381
693978002832	MraZ protein; Region: MraZ; pfam02381
693978002833	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
693978002834	Predicted GTPase [General function prediction only]; Region: COG0218
693978002835	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
693978002836	G1 box; other site
693978002837	GTP/Mg2+ binding site [chemical binding]; other site
693978002838	Switch I region; other site
693978002839	G2 box; other site
693978002840	G3 box; other site
693978002841	Switch II region; other site
693978002842	G4 box; other site
693978002843	G5 box; other site
693978002844	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
693978002845	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
693978002846	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
693978002847	Found in ATP-dependent protease La (LON); Region: LON; smart00464
693978002848	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978002849	Walker A motif; other site
693978002850	ATP binding site [chemical binding]; other site
693978002851	Walker B motif; other site
693978002852	arginine finger; other site
693978002853	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
693978002854	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978002855	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
693978002856	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
693978002857	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
693978002858	NADP binding site [chemical binding]; other site
693978002859	active site
693978002860	putative substrate binding site [chemical binding]; other site
693978002861	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
693978002862	active site
693978002863	periplasmic chaperone; Provisional; Region: PRK10780
693978002864	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
693978002865	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
693978002866	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
693978002867	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
693978002868	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
693978002869	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
693978002870	Surface antigen; Region: Bac_surface_Ag; cl03097
693978002871	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
693978002872	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
693978002873	catalytic residue [active]
693978002874	putative FPP diphosphate  binding site; other site
693978002875	putative FPP binding hydrophobic cleft; other site
693978002876	dimer interface [polypeptide binding]; other site
693978002877	putative IPP diphosphate binding site; other site
693978002878	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978002879	Domain of unknown function (DUF389); Region: DUF389; cl00781
693978002880	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
693978002881	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
693978002882	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
693978002883	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
693978002884	TRAM domain; Region: TRAM; cl01282
693978002885	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693978002886	S-adenosylmethionine binding site [chemical binding]; other site
693978002887	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
693978002888	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978002889	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
693978002890	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
693978002891	putative catalytic site [active]
693978002892	putative metal binding site [ion binding]; other site
693978002893	putative phosphate binding site [ion binding]; other site
693978002894	Rhomboid family; Region: Rhomboid; cl11446
693978002895	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
693978002896	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693978002897	ATP binding site [chemical binding]; other site
693978002898	Mg2+ binding site [ion binding]; other site
693978002899	G-X-G motif; other site
693978002900	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
693978002901	ATP binding site [chemical binding]; other site
693978002902	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
693978002903	VPS10 domain; Region: VPS10; smart00602
693978002904	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
693978002905	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978002906	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
693978002907	SelR domain; Region: SelR; pfam01641
693978002908	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693978002909	non-specific DNA binding site [nucleotide binding]; other site
693978002910	salt bridge; other site
693978002911	sequence-specific DNA binding site [nucleotide binding]; other site
693978002912	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
693978002913	nucleoside/Zn binding site; other site
693978002914	dimer interface [polypeptide binding]; other site
693978002915	catalytic motif [active]
693978002916	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
693978002917	E-class dimer interface [polypeptide binding]; other site
693978002918	P-class dimer interface [polypeptide binding]; other site
693978002919	active site
693978002920	Cu2+ binding site [ion binding]; other site
693978002921	Zn2+ binding site [ion binding]; other site
693978002922	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
693978002923	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
693978002924	dimer interface [polypeptide binding]; other site
693978002925	tetramer interface [polypeptide binding]; other site
693978002926	PYR/PP interface [polypeptide binding]; other site
693978002927	TPP binding site [chemical binding]; other site
693978002928	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
693978002929	TPP-binding site; other site
693978002930	Peptidase S46; Region: Peptidase_S46; pfam10459
693978002931	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
693978002932	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
693978002933	Phosphoglycerate kinase; Region: PGK; pfam00162
693978002934	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
693978002935	substrate binding site [chemical binding]; other site
693978002936	hinge regions; other site
693978002937	ADP binding site [chemical binding]; other site
693978002938	catalytic site [active]
693978002939	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
693978002940	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
693978002941	active site
693978002942	purine riboside binding site [chemical binding]; other site
693978002943	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693978002944	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978002945	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978002946	starch binding outer membrane protein SusD; Region: SusD; cd08977
693978002947	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
693978002948	M28 Zn-Peptidases; Region: M28_like_4; cd08015
693978002949	metal binding site [ion binding]; metal-binding site
693978002950	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
693978002951	DDE superfamily endonuclease; Region: DDE_4; cl15789
693978002952	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693978002953	S-adenosylmethionine binding site [chemical binding]; other site
693978002954	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
693978002955	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978002956	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
693978002957	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
693978002958	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
693978002959	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
693978002960	active site
693978002961	nucleophile elbow; other site
693978002962	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
693978002963	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
693978002964	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
693978002965	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
693978002966	active site
693978002967	substrate-binding site [chemical binding]; other site
693978002968	metal-binding site [ion binding]
693978002969	ATP binding site [chemical binding]; other site
693978002970	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693978002971	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
693978002972	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
693978002973	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
693978002974	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
693978002975	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
693978002976	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
693978002977	active site
693978002978	substrate binding site [chemical binding]; other site
693978002979	metal binding site [ion binding]; metal-binding site
693978002980	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693978002981	binding surface
693978002982	TPR motif; other site
693978002983	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693978002984	TPR motif; other site
693978002985	binding surface
693978002986	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693978002987	binding surface
693978002988	TPR motif; other site
693978002989	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693978002990	binding surface
693978002991	TPR motif; other site
693978002992	TPR repeat; Region: TPR_11; pfam13414
693978002993	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
693978002994	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
693978002995	Domain of unknown function DUF20; Region: UPF0118; pfam01594
693978002996	chorismate binding enzyme; Region: Chorismate_bind; cl10555
693978002997	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
693978002998	substrate-cofactor binding pocket; other site
693978002999	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978003000	catalytic residue [active]
693978003001	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978003002	Fic family protein [Function unknown]; Region: COG3177
693978003003	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
693978003004	Fic/DOC family; Region: Fic; cl00960
693978003005	Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428
693978003006	Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696
693978003007	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978003008	aspartate aminotransferase; Provisional; Region: PRK07568
693978003009	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
693978003010	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978003011	homodimer interface [polypeptide binding]; other site
693978003012	catalytic residue [active]
693978003013	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
693978003014	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693978003015	active site
693978003016	HIGH motif; other site
693978003017	nucleotide binding site [chemical binding]; other site
693978003018	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693978003019	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693978003020	active site
693978003021	KMSKS motif; other site
693978003022	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
693978003023	tRNA binding surface [nucleotide binding]; other site
693978003024	anticodon binding site; other site
693978003025	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
693978003026	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
693978003027	lipoprotein signal peptidase; Provisional; Region: PRK14787
693978003028	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
693978003029	putative active site [active]
693978003030	GTP-binding protein LepA; Provisional; Region: PRK05433
693978003031	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
693978003032	G1 box; other site
693978003033	putative GEF interaction site [polypeptide binding]; other site
693978003034	GTP/Mg2+ binding site [chemical binding]; other site
693978003035	Switch I region; other site
693978003036	G2 box; other site
693978003037	G3 box; other site
693978003038	Switch II region; other site
693978003039	G4 box; other site
693978003040	G5 box; other site
693978003041	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
693978003042	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
693978003043	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
693978003044	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
693978003045	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
693978003046	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
693978003047	putative ABC transporter; Region: ycf24; CHL00085
693978003048	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
693978003049	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
693978003050	NlpE N-terminal domain; Region: NlpE; cl01138
693978003051	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
693978003052	active site
693978003053	homotetramer interface [polypeptide binding]; other site
693978003054	Domain of unknown function (DUF336); Region: DUF336; cl01249
693978003055	FeS assembly ATPase SufC; Region: sufC; TIGR01978
693978003056	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
693978003057	Walker A/P-loop; other site
693978003058	ATP binding site [chemical binding]; other site
693978003059	Q-loop/lid; other site
693978003060	ABC transporter signature motif; other site
693978003061	Walker B; other site
693978003062	D-loop; other site
693978003063	H-loop/switch region; other site
693978003064	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
693978003065	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
693978003066	Type III pantothenate kinase; Region: Pan_kinase; cl09130
693978003067	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
693978003068	Zn binding site [ion binding]; other site
693978003069	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693978003070	dimer interface [polypeptide binding]; other site
693978003071	phosphorylation site [posttranslational modification]
693978003072	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693978003073	ATP binding site [chemical binding]; other site
693978003074	Mg2+ binding site [ion binding]; other site
693978003075	G-X-G motif; other site
693978003076	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
693978003077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693978003078	active site
693978003079	phosphorylation site [posttranslational modification]
693978003080	intermolecular recognition site; other site
693978003081	dimerization interface [polypeptide binding]; other site
693978003082	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
693978003083	DNA binding site [nucleotide binding]
693978003084	Domain of unknown function (DUF4290); Region: DUF4290; pfam14123
693978003085	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
693978003086	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
693978003087	hinge; other site
693978003088	active site
693978003089	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978003090	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
693978003091	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
693978003092	putative catalytic residue [active]
693978003093	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
693978003094	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
693978003095	Uncharacterized conserved protein [Function unknown]; Region: COG3743
693978003096	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
693978003097	FAD binding domain; Region: FAD_binding_4; pfam01565
693978003098	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
693978003099	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
693978003100	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
693978003101	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
693978003102	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
693978003103	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978003104	Walker A/P-loop; other site
693978003105	ATP binding site [chemical binding]; other site
693978003106	Q-loop/lid; other site
693978003107	ABC transporter signature motif; other site
693978003108	Walker B; other site
693978003109	D-loop; other site
693978003110	H-loop/switch region; other site
693978003111	putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930
693978003112	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
693978003113	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
693978003114	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
693978003115	active site
693978003116	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
693978003117	dimer interface [polypeptide binding]; other site
693978003118	substrate binding site [chemical binding]; other site
693978003119	catalytic residues [active]
693978003120	thymidine kinase; Provisional; Region: PRK04296
693978003121	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
693978003122	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
693978003123	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
693978003124	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
693978003125	NAD(P) binding site [chemical binding]; other site
693978003126	homotetramer interface [polypeptide binding]; other site
693978003127	homodimer interface [polypeptide binding]; other site
693978003128	active site
693978003129	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978003130	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
693978003131	DNA binding residues [nucleotide binding]
693978003132	dimerization interface [polypeptide binding]; other site
693978003133	ribonuclease R; Region: RNase_R; TIGR02063
693978003134	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
693978003135	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
693978003136	RNB domain; Region: RNB; pfam00773
693978003137	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
693978003138	RNA binding site [nucleotide binding]; other site
693978003139	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
693978003140	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
693978003141	Clp protease ATP binding subunit; Region: clpC; CHL00095
693978003142	Clp amino terminal domain; Region: Clp_N; pfam02861
693978003143	Clp amino terminal domain; Region: Clp_N; pfam02861
693978003144	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978003145	Walker A motif; other site
693978003146	ATP binding site [chemical binding]; other site
693978003147	Walker B motif; other site
693978003148	arginine finger; other site
693978003149	UvrB/uvrC motif; Region: UVR; pfam02151
693978003150	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978003151	Walker A motif; other site
693978003152	ATP binding site [chemical binding]; other site
693978003153	Walker B motif; other site
693978003154	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
693978003155	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978003156	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
693978003157	Fe-S metabolism associated domain; Region: SufE; cl00951
693978003158	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
693978003159	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
693978003160	putative active site [active]
693978003161	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693978003162	active site
693978003163	Predicted glycosyltransferase involved in capsule biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG4092
693978003164	Survival protein SurE; Region: SurE; cl00448
693978003165	C-terminal peptidase (prc); Region: prc; TIGR00225
693978003166	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
693978003167	protein binding site [polypeptide binding]; other site
693978003168	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
693978003169	Catalytic dyad [active]
693978003170	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
693978003171	Mechanosensitive ion channel; Region: MS_channel; pfam00924
693978003172	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978003173	Protein of unknown function, DUF393; Region: DUF393; cl01136
693978003174	Haem-binding domain; Region: Haem_bd; pfam14376
693978003175	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
693978003176	active site
693978003177	trimer interface [polypeptide binding]; other site
693978003178	dimer interface [polypeptide binding]; other site
693978003179	PSP1 C-terminal conserved region; Region: PSP1; cl00770
693978003180	GldH lipoprotein; Region: GldH_lipo; cl11905
693978003181	Transglycosylase; Region: Transgly; cl07896
693978003182	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
693978003183	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978003184	ATP binding site [chemical binding]; other site
693978003185	substrate interface [chemical binding]; other site
693978003186	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
693978003187	DNA binding residues [nucleotide binding]
693978003188	dimerization interface [polypeptide binding]; other site
693978003189	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
693978003190	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
693978003191	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978003192	Sporulation related domain; Region: SPOR; cl10051
693978003193	Cytochrome c; Region: Cytochrom_C; cl11414
693978003194	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
693978003195	heme-binding residues [chemical binding]; other site
693978003196	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
693978003197	molybdopterin cofactor binding site; other site
693978003198	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
693978003199	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
693978003200	Polysulphide reductase, NrfD; Region: NrfD; cl01295
693978003201	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
693978003202	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
693978003203	Cytochrome c; Region: Cytochrom_C; cl11414
693978003204	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
693978003205	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693978003206	active site
693978003207	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
693978003208	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
693978003209	homopentamer interface [polypeptide binding]; other site
693978003210	active site
693978003211	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
693978003212	Acyltransferase family; Region: Acyl_transf_3; pfam01757
693978003213	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
693978003214	active site
693978003215	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
693978003216	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
693978003217	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
693978003218	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
693978003219	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
693978003220	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
693978003221	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
693978003222	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978003223	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
693978003224	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
693978003225	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
693978003226	active site
693978003227	interdomain interaction site; other site
693978003228	putative metal-binding site [ion binding]; other site
693978003229	nucleotide binding site [chemical binding]; other site
693978003230	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
693978003231	domain I; other site
693978003232	DNA binding groove [nucleotide binding]
693978003233	phosphate binding site [ion binding]; other site
693978003234	domain II; other site
693978003235	domain III; other site
693978003236	nucleotide binding site [chemical binding]; other site
693978003237	catalytic site [active]
693978003238	domain IV; other site
693978003239	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
693978003240	Arginase family; Region: Arginase; cl00306
693978003241	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693978003242	active site
693978003243	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
693978003244	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
693978003245	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
693978003246	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
693978003247	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978003248	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
693978003249	MutS domain I; Region: MutS_I; pfam01624
693978003250	MutS domain II; Region: MutS_II; pfam05188
693978003251	MutS family domain IV; Region: MutS_IV; pfam05190
693978003252	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
693978003253	Walker A/P-loop; other site
693978003254	ATP binding site [chemical binding]; other site
693978003255	Q-loop/lid; other site
693978003256	ABC transporter signature motif; other site
693978003257	Walker B; other site
693978003258	D-loop; other site
693978003259	H-loop/switch region; other site
693978003260	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
693978003261	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
693978003262	Ligand binding site; other site
693978003263	Putative Catalytic site; other site
693978003264	DXD motif; other site
693978003265	Domain of unknown function (DUF4296); Region: DUF4296; pfam14129
693978003266	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
693978003267	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
693978003268	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
693978003269	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
693978003270	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
693978003271	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
693978003272	Oligomerisation domain; Region: Oligomerisation; cl00519
693978003273	FtsH Extracellular; Region: FtsH_ext; pfam06480
693978003274	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
693978003275	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978003276	Walker A motif; other site
693978003277	ATP binding site [chemical binding]; other site
693978003278	Walker B motif; other site
693978003279	arginine finger; other site
693978003280	Peptidase family M41; Region: Peptidase_M41; pfam01434
693978003281	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
693978003282	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693978003283	non-specific DNA binding site [nucleotide binding]; other site
693978003284	salt bridge; other site
693978003285	sequence-specific DNA binding site [nucleotide binding]; other site
693978003286	Predicted helicase [General function prediction only]; Region: COG4889
693978003287	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
693978003288	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
693978003289	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978003290	ATP binding site [chemical binding]; other site
693978003291	putative Mg++ binding site [ion binding]; other site
693978003292	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693978003293	active site
693978003294	DNA binding site [nucleotide binding]
693978003295	Int/Topo IB signature motif; other site
693978003296	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
693978003297	RIP metalloprotease RseP; Region: TIGR00054
693978003298	active site
693978003299	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
693978003300	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
693978003301	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
693978003302	putative substrate binding region [chemical binding]; other site
693978003303	Predicted amidohydrolase [General function prediction only]; Region: COG0388
693978003304	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
693978003305	putative active site [active]
693978003306	catalytic triad [active]
693978003307	dimer interface [polypeptide binding]; other site
693978003308	multimer interface [polypeptide binding]; other site
693978003309	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
693978003310	ATP-grasp domain; Region: ATP-grasp_4; cl03087
693978003311	excinuclease ABC subunit B; Provisional; Region: PRK05298
693978003312	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693978003313	ATP binding site [chemical binding]; other site
693978003314	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693978003315	nucleotide binding region [chemical binding]; other site
693978003316	ATP-binding site [chemical binding]; other site
693978003317	Ultra-violet resistance protein B; Region: UvrB; pfam12344
693978003318	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
693978003319	DinB superfamily; Region: DinB_2; pfam12867
693978003320	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978003321	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
693978003322	catalytic triad [active]
693978003323	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
693978003324	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
693978003325	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693978003326	active site
693978003327	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
693978003328	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
693978003329	5S rRNA interface [nucleotide binding]; other site
693978003330	CTC domain interface [polypeptide binding]; other site
693978003331	L16 interface [polypeptide binding]; other site
693978003332	SprT-like family; Region: SprT-like; pfam10263
693978003333	SprT homologues; Region: SprT; cl01182
693978003334	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
693978003335	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
693978003336	Substrate binding site; other site
693978003337	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
693978003338	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
693978003339	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978003340	Walker A motif; other site
693978003341	ATP binding site [chemical binding]; other site
693978003342	Walker B motif; other site
693978003343	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
693978003344	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978003345	RNA polymerase sigma factor; Provisional; Region: PRK12513
693978003346	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693978003347	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693978003348	DNA binding residues [nucleotide binding]
693978003349	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
693978003350	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693978003351	motif II; other site
693978003352	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
693978003353	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
693978003354	active site
693978003355	HIGH motif; other site
693978003356	dimer interface [polypeptide binding]; other site
693978003357	KMSKS motif; other site
693978003358	LysE type translocator; Region: LysE; cl00565
693978003359	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
693978003360	dimer interface [polypeptide binding]; other site
693978003361	catalytic triad [active]
693978003362	Restriction endonuclease; Region: Mrr_cat; cl00516
693978003363	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
693978003364	Histidine kinase; Region: His_kinase; pfam06580
693978003365	two-component response regulator; Provisional; Region: PRK14084
693978003366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693978003367	active site
693978003368	phosphorylation site [posttranslational modification]
693978003369	intermolecular recognition site; other site
693978003370	dimerization interface [polypeptide binding]; other site
693978003371	LytTr DNA-binding domain; Region: LytTR; cl04498
693978003372	Tic20-like protein; Region: Tic20; pfam09685
693978003373	NlpC/P60 family; Region: NLPC_P60; cl11438
693978003374	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
693978003375	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
693978003376	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
693978003377	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
693978003378	Rhomboid family; Region: Rhomboid; cl11446
693978003379	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
693978003380	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
693978003381	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
693978003382	FAD binding pocket [chemical binding]; other site
693978003383	conserved FAD binding motif [chemical binding]; other site
693978003384	phosphate binding motif [ion binding]; other site
693978003385	beta-alpha-beta structure motif; other site
693978003386	NAD binding pocket [chemical binding]; other site
693978003387	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
693978003388	A new structural DNA glycosylase; Region: AlkD_like; cd06561
693978003389	active site
693978003390	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
693978003391	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978003392	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
693978003393	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978003394	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
693978003395	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978003396	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978003397	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
693978003398	dimer interface [polypeptide binding]; other site
693978003399	FMN binding site [chemical binding]; other site
693978003400	Surface antigen; Region: Bac_surface_Ag; cl03097
693978003401	NUMOD4 motif; Region: NUMOD4; pfam07463
693978003402	HNH endonuclease; Region: HNH_3; pfam13392
693978003403	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
693978003404	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
693978003405	HflX GTPase family; Region: HflX; cd01878
693978003406	G1 box; other site
693978003407	GTP/Mg2+ binding site [chemical binding]; other site
693978003408	Switch I region; other site
693978003409	G2 box; other site
693978003410	G3 box; other site
693978003411	Switch II region; other site
693978003412	G4 box; other site
693978003413	G5 box; other site
693978003414	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
693978003415	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
693978003416	FeoA domain; Region: FeoA; cl00838
693978003417	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
693978003418	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
693978003419	G1 box; other site
693978003420	GTP/Mg2+ binding site [chemical binding]; other site
693978003421	Switch I region; other site
693978003422	G2 box; other site
693978003423	G3 box; other site
693978003424	Switch II region; other site
693978003425	G4 box; other site
693978003426	G5 box; other site
693978003427	Nucleoside recognition; Region: Gate; cl00486
693978003428	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
693978003429	Nucleoside recognition; Region: Gate; cl00486
693978003430	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
693978003431	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
693978003432	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
693978003433	Active site serine [active]
693978003434	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
693978003435	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
693978003436	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
693978003437	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
693978003438	transcription termination factor NusA; Region: NusA; TIGR01953
693978003439	NusA N-terminal domain; Region: NusA_N; pfam08529
693978003440	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
693978003441	RNA binding site [nucleotide binding]; other site
693978003442	homodimer interface [polypeptide binding]; other site
693978003443	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
693978003444	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
693978003445	G-X-X-G motif; other site
693978003446	translation initiation factor IF-2; Region: IF-2; TIGR00487
693978003447	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
693978003448	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
693978003449	G1 box; other site
693978003450	putative GEF interaction site [polypeptide binding]; other site
693978003451	GTP/Mg2+ binding site [chemical binding]; other site
693978003452	Switch I region; other site
693978003453	G2 box; other site
693978003454	G3 box; other site
693978003455	Switch II region; other site
693978003456	G4 box; other site
693978003457	G5 box; other site
693978003458	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
693978003459	Translation-initiation factor 2; Region: IF-2; pfam11987
693978003460	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
693978003461	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693978003462	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
693978003463	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978003464	starch binding outer membrane protein SusD; Region: SusD; cd08977
693978003465	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
693978003466	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
693978003467	autolysin; Reviewed; Region: PRK06347
693978003468	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
693978003469	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
693978003470	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
693978003471	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
693978003472	ligand binding site [chemical binding]; other site
693978003473	Acyl transferase domain; Region: Acyl_transf_1; cl08282
693978003474	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
693978003475	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
693978003476	catalytic residues [active]
693978003477	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
693978003478	active site residue [active]
693978003479	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
693978003480	active site residue [active]
693978003481	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
693978003482	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
693978003483	active site residue [active]
693978003484	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
693978003485	active site residue [active]
693978003486	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
693978003487	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
693978003488	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
693978003489	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
693978003490	active site
693978003491	catalytic site [active]
693978003492	substrate binding site [chemical binding]; other site
693978003493	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
693978003494	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
693978003495	Walker A/P-loop; other site
693978003496	ATP binding site [chemical binding]; other site
693978003497	Q-loop/lid; other site
693978003498	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
693978003499	Q-loop/lid; other site
693978003500	ABC transporter signature motif; other site
693978003501	Walker B; other site
693978003502	D-loop; other site
693978003503	H-loop/switch region; other site
693978003504	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978003505	Protein of unknown function (DUF502); Region: DUF502; cl01107
693978003506	biotin synthase; Region: bioB; TIGR00433
693978003507	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693978003508	FeS/SAM binding site; other site
693978003509	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
693978003510	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978003511	thiamine-monophosphate kinase; Region: thiL; TIGR01379
693978003512	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
693978003513	ATP binding site [chemical binding]; other site
693978003514	dimerization interface [polypeptide binding]; other site
693978003515	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
693978003516	active site
693978003517	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
693978003518	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
693978003519	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329
693978003520	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
693978003521	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693978003522	FeS/SAM binding site; other site
693978003523	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978003524	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
693978003525	Walker A motif; other site
693978003526	ATP binding site [chemical binding]; other site
693978003527	Walker B motif; other site
693978003528	arginine finger; other site
693978003529	Helix-turn-helix domains; Region: HTH; cl00088
693978003530	Ribonuclease P; Region: Ribonuclease_P; cl00457
693978003531	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
693978003532	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
693978003533	putative ATP binding site [chemical binding]; other site
693978003534	putative substrate interface [chemical binding]; other site
693978003535	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
693978003536	active site
693978003537	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
693978003538	Helix-turn-helix domains; Region: HTH; cl00088
693978003539	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
693978003540	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
693978003541	Substrate binding site; other site
693978003542	metal-binding site
693978003543	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
693978003544	Flavoprotein; Region: Flavoprotein; cl08021
693978003545	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
693978003546	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
693978003547	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
693978003548	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978003549	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
693978003550	NAD(P) binding site [chemical binding]; other site
693978003551	active site
693978003552	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
693978003553	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
693978003554	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
693978003555	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693978003556	nucleotide binding region [chemical binding]; other site
693978003557	ATP-binding site [chemical binding]; other site
693978003558	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978003559	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
693978003560	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
693978003561	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
693978003562	GTP-binding protein Der; Reviewed; Region: PRK00093
693978003563	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
693978003564	G1 box; other site
693978003565	GTP/Mg2+ binding site [chemical binding]; other site
693978003566	Switch I region; other site
693978003567	G2 box; other site
693978003568	Switch II region; other site
693978003569	G3 box; other site
693978003570	G4 box; other site
693978003571	G5 box; other site
693978003572	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
693978003573	G1 box; other site
693978003574	GTP/Mg2+ binding site [chemical binding]; other site
693978003575	Switch I region; other site
693978003576	G2 box; other site
693978003577	G3 box; other site
693978003578	Switch II region; other site
693978003579	G4 box; other site
693978003580	G5 box; other site
693978003581	rod shape-determining protein MreB; Provisional; Region: PRK13927
693978003582	Cell division protein FtsA; Region: FtsA; cl11496
693978003583	rod shape-determining protein MreC; Provisional; Region: PRK13922
693978003584	rod shape-determining protein MreC; Region: MreC; pfam04085
693978003585	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
693978003586	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
693978003587	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
693978003588	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
693978003589	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
693978003590	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693978003591	ligand binding site [chemical binding]; other site
693978003592	O-methyltransferase; Region: Methyltransf_3; pfam01596
693978003593	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693978003594	S-adenosylmethionine binding site [chemical binding]; other site
693978003595	Bacterial SH3 domain; Region: SH3_3; cl02551
693978003596	NlpC/P60 family; Region: NLPC_P60; cl11438
693978003597	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
693978003598	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
693978003599	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
693978003600	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
693978003601	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693978003602	N-terminal plug; other site
693978003603	ligand-binding site [chemical binding]; other site
693978003604	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
693978003605	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
693978003606	Disulphide isomerase; Region: Disulph_isomer; cl05813
693978003607	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
693978003608	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
693978003609	substrate binding site [chemical binding]; other site
693978003610	active site
693978003611	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
693978003612	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
693978003613	active site
693978003614	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
693978003615	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189
693978003616	domain interfaces; other site
693978003617	active site
693978003618	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
693978003619	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
693978003620	tRNA; other site
693978003621	putative tRNA binding site [nucleotide binding]; other site
693978003622	putative NADP binding site [chemical binding]; other site
693978003623	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
693978003624	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
693978003625	ligand binding site [chemical binding]; other site
693978003626	flexible hinge region; other site
693978003627	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978003628	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
693978003629	Phosphate transporter family; Region: PHO4; cl00396
693978003630	Phosphate transporter family; Region: PHO4; cl00396
693978003631	fumarate hydratase; Provisional; Region: PRK15389
693978003632	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
693978003633	Fumarase C-terminus; Region: Fumerase_C; cl00795
693978003634	peptidase T; Region: peptidase-T; TIGR01882
693978003635	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
693978003636	metal binding site [ion binding]; metal-binding site
693978003637	dimer interface [polypeptide binding]; other site
693978003638	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
693978003639	active site
693978003640	catalytic residues [active]
693978003641	metal binding site [ion binding]; metal-binding site
693978003642	glycyl-tRNA synthetase; Provisional; Region: PRK04173
693978003643	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
693978003644	motif 1; other site
693978003645	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774
693978003646	active site
693978003647	motif 2; other site
693978003648	motif 3; other site
693978003649	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
693978003650	anticodon binding site; other site
693978003651	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
693978003652	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
693978003653	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
693978003654	catalytic residue [active]
693978003655	Flagellin N-methylase; Region: FliB; cl00497
693978003656	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
693978003657	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
693978003658	dimer interface [polypeptide binding]; other site
693978003659	active site
693978003660	heme binding site [chemical binding]; other site
693978003661	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
693978003662	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
693978003663	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
693978003664	Coenzyme A binding pocket [chemical binding]; other site
693978003665	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
693978003666	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
693978003667	RmuC family; Region: RmuC; pfam02646
693978003668	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
693978003669	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
693978003670	active site
693978003671	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
693978003672	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
693978003673	dimerization interface [polypeptide binding]; other site
693978003674	DPS ferroxidase diiron center [ion binding]; other site
693978003675	ion pore; other site
693978003676	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
693978003677	S17 interaction site [polypeptide binding]; other site
693978003678	S8 interaction site; other site
693978003679	16S rRNA interaction site [nucleotide binding]; other site
693978003680	streptomycin interaction site [chemical binding]; other site
693978003681	23S rRNA interaction site [nucleotide binding]; other site
693978003682	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
693978003683	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
693978003684	elongation factor G; Reviewed; Region: PRK12739
693978003685	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
693978003686	G1 box; other site
693978003687	putative GEF interaction site [polypeptide binding]; other site
693978003688	GTP/Mg2+ binding site [chemical binding]; other site
693978003689	Switch I region; other site
693978003690	G2 box; other site
693978003691	G3 box; other site
693978003692	Switch II region; other site
693978003693	G4 box; other site
693978003694	G5 box; other site
693978003695	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
693978003696	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
693978003697	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
693978003698	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
693978003699	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978003700	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978003701	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978003702	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978003703	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978003704	NAD(P) binding site [chemical binding]; other site
693978003705	active site
693978003706	ferrochelatase; Reviewed; Region: hemH; PRK00035
693978003707	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
693978003708	C-terminal domain interface [polypeptide binding]; other site
693978003709	active site
693978003710	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
693978003711	active site
693978003712	N-terminal domain interface [polypeptide binding]; other site
693978003713	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
693978003714	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
693978003715	NifU-like domain; Region: NifU; cl00484
693978003716	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
693978003717	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
693978003718	trimer interface [polypeptide binding]; other site
693978003719	putative metal binding site [ion binding]; other site
693978003720	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
693978003721	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978003722	AAA domain; Region: AAA_22; pfam13401
693978003723	Family description; Region: UvrD_C_2; cl15862
693978003724	Phosphotransferase enzyme family; Region: APH; pfam01636
693978003725	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
693978003726	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
693978003727	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
693978003728	putative active site [active]
693978003729	catalytic triad [active]
693978003730	putative dimer interface [polypeptide binding]; other site
693978003731	VanZ like family; Region: VanZ; cl01971
693978003732	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
693978003733	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
693978003734	GIY-YIG motif/motif A; other site
693978003735	active site
693978003736	catalytic site [active]
693978003737	putative DNA binding site [nucleotide binding]; other site
693978003738	metal binding site [ion binding]; metal-binding site
693978003739	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
693978003740	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
693978003741	Cation efflux family; Region: Cation_efflux; cl00316
693978003742	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
693978003743	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
693978003744	CoA-binding site [chemical binding]; other site
693978003745	ATP-binding [chemical binding]; other site
693978003746	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
693978003747	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
693978003748	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978003749	Walker A motif; other site
693978003750	ATP binding site [chemical binding]; other site
693978003751	Walker B motif; other site
693978003752	arginine finger; other site
693978003753	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
693978003754	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
693978003755	Ferritin-like domain; Region: Ferritin; pfam00210
693978003756	ferroxidase diiron center [ion binding]; other site
693978003757	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
693978003758	nudix motif; other site
693978003759	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
693978003760	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
693978003761	active site
693978003762	Int/Topo IB signature motif; other site
693978003763	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
693978003764	catalytic motif [active]
693978003765	Zn binding site [ion binding]; other site
693978003766	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
693978003767	enoyl-CoA hydratase; Provisional; Region: PRK07658
693978003768	substrate binding site [chemical binding]; other site
693978003769	oxyanion hole (OAH) forming residues; other site
693978003770	trimer interface [polypeptide binding]; other site
693978003771	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
693978003772	active site
693978003773	catalytic tetrad [active]
693978003774	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
693978003775	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
693978003776	tetramer interface [polypeptide binding]; other site
693978003777	heme binding pocket [chemical binding]; other site
693978003778	NADPH binding site [chemical binding]; other site
693978003779	Transcriptional regulator [Transcription]; Region: LysR; COG0583
693978003780	Helix-turn-helix domains; Region: HTH; cl00088
693978003781	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
693978003782	dimerization interface [polypeptide binding]; other site
693978003783	S-adenosylmethionine synthetase; Validated; Region: PRK05250
693978003784	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
693978003785	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
693978003786	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
693978003787	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
693978003788	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
693978003789	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
693978003790	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
693978003791	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
693978003792	Preprotein translocase subunit; Region: YajC; cl00806
693978003793	Uncharacterized conserved protein [Function unknown]; Region: COG2966
693978003794	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
693978003795	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
693978003796	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
693978003797	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978003798	NAD(P) binding site [chemical binding]; other site
693978003799	active site
693978003800	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
693978003801	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693978003802	active site
693978003803	HIGH motif; other site
693978003804	nucleotide binding site [chemical binding]; other site
693978003805	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
693978003806	KMSKS motif; other site
693978003807	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
693978003808	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
693978003809	GTP cyclohydrolase I; Provisional; Region: PLN03044
693978003810	active site
693978003811	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
693978003812	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978003813	UDP-galactopyranose mutase; Region: GLF; pfam03275
693978003814	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693978003815	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693978003816	active site
693978003817	OpgC protein; Region: OpgC_C; cl00792
693978003818	Acyltransferase family; Region: Acyl_transf_3; pfam01757
693978003819	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
693978003820	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978003821	active site
693978003822	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693978003823	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693978003824	active site
693978003825	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
693978003826	trimer interface [polypeptide binding]; other site
693978003827	active site
693978003828	substrate binding site [chemical binding]; other site
693978003829	CoA binding site [chemical binding]; other site
693978003830	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
693978003831	active site
693978003832	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
693978003833	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
693978003834	MatE; Region: MatE; cl10513
693978003835	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
693978003836	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
693978003837	active site
693978003838	Substrate binding site; other site
693978003839	Mg++ binding site; other site
693978003840	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
693978003841	putative trimer interface [polypeptide binding]; other site
693978003842	putative CoA binding site [chemical binding]; other site
693978003843	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
693978003844	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
693978003845	Peptidase family M23; Region: Peptidase_M23; pfam01551
693978003846	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
693978003847	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
693978003848	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
693978003849	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
693978003850	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
693978003851	dimerization interface [polypeptide binding]; other site
693978003852	active site
693978003853	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
693978003854	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
693978003855	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
693978003856	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
693978003857	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
693978003858	Protein of unknown function (DUF3810); Region: DUF3810; pfam12725
693978003859	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
693978003860	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
693978003861	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
693978003862	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
693978003863	putative acyl-acceptor binding pocket; other site
693978003864	GtrA-like protein; Region: GtrA; cl00971
693978003865	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978003866	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978003867	Restriction endonuclease EcoRI; Region: EcoRI; pfam02963
693978003868	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
693978003869	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
693978003870	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
693978003871	Malic enzyme, N-terminal domain; Region: malic; pfam00390
693978003872	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
693978003873	putative NAD(P) binding site [chemical binding]; other site
693978003874	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
693978003875	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
693978003876	Helix-turn-helix domains; Region: HTH; cl00088
693978003877	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
693978003878	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
693978003879	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
693978003880	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
693978003881	active site
693978003882	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
693978003883	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
693978003884	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
693978003885	Walker A/P-loop; other site
693978003886	ATP binding site [chemical binding]; other site
693978003887	Q-loop/lid; other site
693978003888	ABC transporter signature motif; other site
693978003889	Walker B; other site
693978003890	D-loop; other site
693978003891	H-loop/switch region; other site
693978003892	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
693978003893	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
693978003894	transcription termination factor Rho; Provisional; Region: PRK12608
693978003895	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
693978003896	RNA binding site [nucleotide binding]; other site
693978003897	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
693978003898	multimer interface [polypeptide binding]; other site
693978003899	Walker A motif; other site
693978003900	ATP binding site [chemical binding]; other site
693978003901	Walker B motif; other site
693978003902	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247
693978003903	Phytase; Region: Phytase; pfam02333
693978003904	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
693978003905	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
693978003906	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978003907	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693978003908	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
693978003909	rRNA interaction site [nucleotide binding]; other site
693978003910	S8 interaction site; other site
693978003911	putative laminin-1 binding site; other site
693978003912	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
693978003913	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
693978003914	23S rRNA interface [nucleotide binding]; other site
693978003915	L3 interface [polypeptide binding]; other site
693978003916	Domain of unknown function DUF59; Region: DUF59; cl00941
693978003917	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
693978003918	active site
693978003919	catalytic site [active]
693978003920	substrate binding site [chemical binding]; other site
693978003921	Nucleoside recognition; Region: Gate; cl00486
693978003922	Nucleoside recognition; Region: Gate; cl00486
693978003923	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
693978003924	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
693978003925	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978003926	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
693978003927	FixH; Region: FixH; cl01254
693978003928	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
693978003929	4Fe-4S binding domain; Region: Fer4_5; pfam12801
693978003930	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
693978003931	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
693978003932	Cytochrome c; Region: Cytochrom_C; cl11414
693978003933	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282
693978003934	putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485
693978003935	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
693978003936	Low-spin heme binding site [chemical binding]; other site
693978003937	Putative water exit pathway; other site
693978003938	Binuclear center (active site) [active]
693978003939	Putative proton exit pathway; other site
693978003940	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
693978003941	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
693978003942	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
693978003943	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
693978003944	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
693978003945	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
693978003946	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
693978003947	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
693978003948	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
693978003949	ligand binding site [chemical binding]; other site
693978003950	flexible hinge region; other site
693978003951	Helix-turn-helix domains; Region: HTH; cl00088
693978003952	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
693978003953	active site
693978003954	oligomerization interface [polypeptide binding]; other site
693978003955	metal binding site [ion binding]; metal-binding site
693978003956	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
693978003957	active site
693978003958	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
693978003959	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
693978003960	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693978003961	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
693978003962	active site
693978003963	DNA binding site [nucleotide binding]
693978003964	Int/Topo IB signature motif; other site
693978003965	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
693978003966	30S subunit binding site; other site
693978003967	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
693978003968	quinone interaction residues [chemical binding]; other site
693978003969	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
693978003970	active site
693978003971	catalytic residues [active]
693978003972	FMN binding site [chemical binding]; other site
693978003973	substrate binding site [chemical binding]; other site
693978003974	elongation factor Tu; Reviewed; Region: PRK12735
693978003975	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
693978003976	G1 box; other site
693978003977	GEF interaction site [polypeptide binding]; other site
693978003978	GTP/Mg2+ binding site [chemical binding]; other site
693978003979	Switch I region; other site
693978003980	G2 box; other site
693978003981	G3 box; other site
693978003982	Switch II region; other site
693978003983	G4 box; other site
693978003984	G5 box; other site
693978003985	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
693978003986	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
693978003987	Antibiotic Binding Site [chemical binding]; other site
693978003988	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
693978003989	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
693978003990	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
693978003991	putative homodimer interface [polypeptide binding]; other site
693978003992	KOW motif; Region: KOW; cl00354
693978003993	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
693978003994	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
693978003995	23S rRNA interface [nucleotide binding]; other site
693978003996	L7/L12 interface [polypeptide binding]; other site
693978003997	putative thiostrepton binding site; other site
693978003998	L25 interface [polypeptide binding]; other site
693978003999	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
693978004000	mRNA/rRNA interface [nucleotide binding]; other site
693978004001	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
693978004002	23S rRNA interface [nucleotide binding]; other site
693978004003	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
693978004004	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
693978004005	peripheral dimer interface [polypeptide binding]; other site
693978004006	core dimer interface [polypeptide binding]; other site
693978004007	L10 interface [polypeptide binding]; other site
693978004008	L11 interface [polypeptide binding]; other site
693978004009	putative EF-Tu interaction site [polypeptide binding]; other site
693978004010	putative EF-G interaction site [polypeptide binding]; other site
693978004011	Thrombospondin type 3 repeat; Region: TSP_3; pfam02412
693978004012	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
693978004013	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
693978004014	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
693978004015	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
693978004016	RPB11 interaction site [polypeptide binding]; other site
693978004017	RPB12 interaction site [polypeptide binding]; other site
693978004018	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
693978004019	RPB3 interaction site [polypeptide binding]; other site
693978004020	RPB1 interaction site [polypeptide binding]; other site
693978004021	RPB11 interaction site [polypeptide binding]; other site
693978004022	RPB10 interaction site [polypeptide binding]; other site
693978004023	RNA polymerase beta' subunit; Region: rpoC1; CHL00018
693978004024	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
693978004025	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
693978004026	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
693978004027	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
693978004028	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
693978004029	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
693978004030	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
693978004031	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
693978004032	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
693978004033	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
693978004034	DNA binding site [nucleotide binding]
693978004035	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
693978004036	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
693978004037	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
693978004038	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978004039	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
693978004040	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978004041	Walker A/P-loop; other site
693978004042	ATP binding site [chemical binding]; other site
693978004043	Q-loop/lid; other site
693978004044	ABC transporter signature motif; other site
693978004045	Walker B; other site
693978004046	D-loop; other site
693978004047	H-loop/switch region; other site
693978004048	ABC transporter; Region: ABC_tran_2; pfam12848
693978004049	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
693978004050	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693978004051	active site
693978004052	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
693978004053	enoyl-CoA hydratase; Provisional; Region: PRK08140
693978004054	substrate binding site [chemical binding]; other site
693978004055	oxyanion hole (OAH) forming residues; other site
693978004056	trimer interface [polypeptide binding]; other site
693978004057	hypothetical protein; Provisional; Region: PRK11820
693978004058	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
693978004059	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
693978004060	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
693978004061	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
693978004062	catalytic site [active]
693978004063	G-X2-G-X-G-K; other site
693978004064	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
693978004065	homooctamer interface [polypeptide binding]; other site
693978004066	active site
693978004067	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
693978004068	lipoyl attachment site [posttranslational modification]; other site
693978004069	VanZ like family; Region: VanZ; cl01971
693978004070	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
693978004071	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
693978004072	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
693978004073	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
693978004074	PLD-like domain; Region: PLDc_2; pfam13091
693978004075	putative active site [active]
693978004076	catalytic site [active]
693978004077	WYL domain; Region: WYL; cl14852
693978004078	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
693978004079	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693978004080	N-terminal plug; other site
693978004081	ligand-binding site [chemical binding]; other site
693978004082	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
693978004083	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
693978004084	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
693978004085	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
693978004086	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
693978004087	putative dimer interface [polypeptide binding]; other site
693978004088	putative anticodon binding site; other site
693978004089	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
693978004090	homodimer interface [polypeptide binding]; other site
693978004091	motif 1; other site
693978004092	motif 2; other site
693978004093	active site
693978004094	motif 3; other site
693978004095	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
693978004096	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
693978004097	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
693978004098	Cupin domain; Region: Cupin_2; cl09118
693978004099	C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cd00037
693978004100	glucokinase, proteobacterial type; Region: glk; TIGR00749
693978004101	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
693978004102	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
693978004103	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
693978004104	motif 1; other site
693978004105	active site
693978004106	motif 2; other site
693978004107	motif 3; other site
693978004108	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
693978004109	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
693978004110	SurA N-terminal domain; Region: SurA_N_3; cl07813
693978004111	PPIC-type PPIASE domain; Region: Rotamase; cl08278
693978004112	PPIC-type PPIASE domain; Region: Rotamase; cl08278
693978004113	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
693978004114	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
693978004115	substrate binding site [chemical binding]; other site
693978004116	ATP binding site [chemical binding]; other site
693978004117	gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512
693978004118	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
693978004119	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
693978004120	minor groove reading motif; other site
693978004121	helix-hairpin-helix signature motif; other site
693978004122	substrate binding pocket [chemical binding]; other site
693978004123	active site
693978004124	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
693978004125	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
693978004126	nudix motif; other site
693978004127	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
693978004128	IHF dimer interface [polypeptide binding]; other site
693978004129	IHF - DNA interface [nucleotide binding]; other site
693978004130	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
693978004131	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
693978004132	homodimer interface [polypeptide binding]; other site
693978004133	oligonucleotide binding site [chemical binding]; other site
693978004134	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
693978004135	active site
693978004136	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693978004137	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
693978004138	starch binding outer membrane protein SusD; Region: SusD; cd08977
693978004139	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
693978004140	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
693978004141	RNA binding surface [nucleotide binding]; other site
693978004142	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
693978004143	active site
693978004144	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
693978004145	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
693978004146	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
693978004147	putative recombination protein RecB; Provisional; Region: PRK13909
693978004148	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978004149	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
693978004150	Integral membrane protein TerC family; Region: TerC; cl10468
693978004151	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
693978004152	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
693978004153	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
693978004154	dimerization interface [polypeptide binding]; other site
693978004155	active site
693978004156	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
693978004157	homodimer interface [polypeptide binding]; other site
693978004158	catalytic residues [active]
693978004159	NAD binding site [chemical binding]; other site
693978004160	substrate binding pocket [chemical binding]; other site
693978004161	flexible flap; other site
693978004162	Protein of unknown function (DUF423); Region: DUF423; cl01008
693978004163	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
693978004164	ATP-grasp domain; Region: ATP-grasp_4; cl03087
693978004165	CoA-ligase; Region: Ligase_CoA; cl02894
693978004166	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
693978004167	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
693978004168	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978004169	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
693978004170	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
693978004171	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
693978004172	homodimer interface [polypeptide binding]; other site
693978004173	substrate-cofactor binding pocket; other site
693978004174	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978004175	catalytic residue [active]
693978004176	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
693978004177	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
693978004178	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978004179	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
693978004180	homoserine O-acetyltransferase; Provisional; Region: PRK06765
693978004181	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
693978004182	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
693978004183	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
693978004184	ATP-grasp domain; Region: ATP-grasp_4; cl03087
693978004185	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
693978004186	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
693978004187	active site
693978004188	(T/H)XGH motif; other site
693978004189	Predicted membrane protein [Function unknown]; Region: COG2860
693978004190	UPF0126 domain; Region: UPF0126; pfam03458
693978004191	UPF0126 domain; Region: UPF0126; pfam03458
693978004192	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
693978004193	Protein of unknown function (DUF1343); Region: DUF1343; cl01598
693978004194	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
693978004195	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693978004196	FtsX-like permease family; Region: FtsX; cl15850
693978004197	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
693978004198	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693978004199	S-adenosylmethionine binding site [chemical binding]; other site
693978004200	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
693978004201	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978004202	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
693978004203	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
693978004204	Coenzyme A binding pocket [chemical binding]; other site
693978004205	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
693978004206	active site residue [active]
693978004207	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
693978004208	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
693978004209	4Fe-4S binding domain; Region: Fer4; cl02805
693978004210	Protein of unknown function (DUF2459); Region: DUF2459; cl09819
693978004211	Peptidase family M23; Region: Peptidase_M23; pfam01551
693978004212	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978004213	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978004214	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978004215	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
693978004216	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
693978004217	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
693978004218	RHS Repeat; Region: RHS_repeat; cl11982
693978004219	RHS Repeat; Region: RHS_repeat; cl11982
693978004220	RHS Repeat; Region: RHS_repeat; cl11982
693978004221	RHS Repeat; Region: RHS_repeat; cl11982
693978004222	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
693978004223	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
693978004224	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
693978004225	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
693978004226	ATPase involved in DNA repair; Region: DUF3686; pfam12458
693978004227	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
693978004228	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978004229	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
693978004230	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
693978004231	PspA/IM30 family; Region: PspA_IM30; pfam04012
693978004232	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
693978004233	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693978004234	non-specific DNA binding site [nucleotide binding]; other site
693978004235	salt bridge; other site
693978004236	sequence-specific DNA binding site [nucleotide binding]; other site
693978004237	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
693978004238	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
693978004239	nucleotide binding pocket [chemical binding]; other site
693978004240	K-X-D-G motif; other site
693978004241	catalytic site [active]
693978004242	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
693978004243	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
693978004244	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
693978004245	Dimer interface [polypeptide binding]; other site
693978004246	BRCT sequence motif; other site
693978004247	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978004248	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978004249	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
693978004250	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693978004251	putative substrate translocation pore; other site
693978004252	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
693978004253	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
693978004254	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
693978004255	active site
693978004256	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
693978004257	transcriptional regulator MalT; Provisional; Region: PRK04841
693978004258	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
693978004259	K+ potassium transporter; Region: K_trans; cl15781
693978004260	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
693978004261	metal binding site 2 [ion binding]; metal-binding site
693978004262	putative DNA binding helix; other site
693978004263	metal binding site 1 [ion binding]; metal-binding site
693978004264	dimer interface [polypeptide binding]; other site
693978004265	structural Zn2+ binding site [ion binding]; other site
693978004266	OstA-like protein; Region: OstA; cl00844
693978004267	OstA-like protein; Region: OstA_2; pfam13100
693978004268	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
693978004269	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
693978004270	OstA-like protein; Region: OstA; cl00844
693978004271	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
693978004272	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
693978004273	inhibitor-cofactor binding pocket; inhibition site
693978004274	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978004275	catalytic residue [active]
693978004276	Sulfatase; Region: Sulfatase; cl10460
693978004277	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
693978004278	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
693978004279	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
693978004280	homodimer interface [polypeptide binding]; other site
693978004281	NAD binding pocket [chemical binding]; other site
693978004282	ATP binding pocket [chemical binding]; other site
693978004283	Mg binding site [ion binding]; other site
693978004284	active-site loop [active]
693978004285	gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514
693978004286	gliding motility-associated protein GldC; Region: GldC; TIGR03515
693978004287	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
693978004288	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
693978004289	trimer interface [polypeptide binding]; other site
693978004290	active site
693978004291	substrate binding site [chemical binding]; other site
693978004292	CoA binding site [chemical binding]; other site
693978004293	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
693978004294	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
693978004295	dimer interface [polypeptide binding]; other site
693978004296	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978004297	catalytic residue [active]
693978004298	Flavin Reductases; Region: FlaRed; cl00801
693978004299	Smr domain; Region: Smr; cl02619
693978004300	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
693978004301	active site
693978004302	metal binding site [ion binding]; metal-binding site
693978004303	homotetramer interface [polypeptide binding]; other site
693978004304	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
693978004305	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
693978004306	dimerization interface 3.5A [polypeptide binding]; other site
693978004307	active site
693978004308	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
693978004309	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
693978004310	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
693978004311	Walker A/P-loop; other site
693978004312	ATP binding site [chemical binding]; other site
693978004313	Q-loop/lid; other site
693978004314	ABC transporter signature motif; other site
693978004315	Walker B; other site
693978004316	D-loop; other site
693978004317	H-loop/switch region; other site
693978004318	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978004319	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
693978004320	Walker A/P-loop; other site
693978004321	ATP binding site [chemical binding]; other site
693978004322	Q-loop/lid; other site
693978004323	ABC transporter signature motif; other site
693978004324	Walker B; other site
693978004325	D-loop; other site
693978004326	H-loop/switch region; other site
693978004327	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
693978004328	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
693978004329	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
693978004330	dimer interface [polypeptide binding]; other site
693978004331	motif 1; other site
693978004332	active site
693978004333	motif 2; other site
693978004334	motif 3; other site
693978004335	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
693978004336	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
693978004337	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693978004338	FeS/SAM binding site; other site
693978004339	HemN C-terminal domain; Region: HemN_C; pfam06969
693978004340	Protein of unknown function (DUF3308); Region: DUF3308; cl14675
693978004341	Pantoate-beta-alanine ligase; Region: PanC; cd00560
693978004342	pantoate--beta-alanine ligase; Region: panC; TIGR00018
693978004343	active site
693978004344	ATP-binding site [chemical binding]; other site
693978004345	pantoate-binding site; other site
693978004346	HXXH motif; other site
693978004347	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
693978004348	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
693978004349	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
693978004350	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
693978004351	glutaminase active site [active]
693978004352	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
693978004353	dimer interface [polypeptide binding]; other site
693978004354	active site
693978004355	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
693978004356	dimer interface [polypeptide binding]; other site
693978004357	active site
693978004358	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
693978004359	gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513
693978004360	gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517
693978004361	GldM N-terminal domain; Region: GldM_N; pfam12081
693978004362	GldM C-terminal domain; Region: GldM_C; pfam12080
693978004363	gliding motility associated protien GldN; Region: GldN; TIGR03523
693978004364	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
693978004365	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
693978004366	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978004367	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978004368	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
693978004369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693978004370	active site
693978004371	phosphorylation site [posttranslational modification]
693978004372	intermolecular recognition site; other site
693978004373	dimerization interface [polypeptide binding]; other site
693978004374	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
693978004375	DNA binding site [nucleotide binding]
693978004376	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693978004377	dimer interface [polypeptide binding]; other site
693978004378	phosphorylation site [posttranslational modification]
693978004379	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693978004380	ATP binding site [chemical binding]; other site
693978004381	Mg2+ binding site [ion binding]; other site
693978004382	G-X-G motif; other site
693978004383	YceI-like domain; Region: YceI; cl01001
693978004384	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
693978004385	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
693978004386	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693978004387	ATP binding site [chemical binding]; other site
693978004388	putative Mg++ binding site [ion binding]; other site
693978004389	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693978004390	nucleotide binding region [chemical binding]; other site
693978004391	ATP-binding site [chemical binding]; other site
693978004392	TRCF domain; Region: TRCF; cl04088
693978004393	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
693978004394	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
693978004395	active site
693978004396	catalytic residues [active]
693978004397	metal binding site [ion binding]; metal-binding site
693978004398	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
693978004399	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
693978004400	homodimer interface [polypeptide binding]; other site
693978004401	metal binding site [ion binding]; metal-binding site
693978004402	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529
693978004403	homodimer interface [polypeptide binding]; other site
693978004404	active site
693978004405	putative chemical substrate binding site [chemical binding]; other site
693978004406	metal binding site [ion binding]; metal-binding site
693978004407	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
693978004408	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
693978004409	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
693978004410	shikimate binding site; other site
693978004411	NAD(P) binding site [chemical binding]; other site
693978004412	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
693978004413	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
693978004414	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
693978004415	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
693978004416	catalytic motif [active]
693978004417	Zn binding site [ion binding]; other site
693978004418	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
693978004419	Response regulator receiver domain; Region: Response_reg; pfam00072
693978004420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693978004421	active site
693978004422	phosphorylation site [posttranslational modification]
693978004423	intermolecular recognition site; other site
693978004424	dimerization interface [polypeptide binding]; other site
693978004425	PglZ domain; Region: PglZ; pfam08665
693978004426	Pirin-related protein [General function prediction only]; Region: COG1741
693978004427	Cupin domain; Region: Cupin_2; cl09118
693978004428	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
693978004429	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
693978004430	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693978004431	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693978004432	DNA binding residues [nucleotide binding]
693978004433	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
693978004434	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cl00178
693978004435	secondary substrate binding site; other site
693978004436	primary substrate binding site; other site
693978004437	inhibition loop; other site
693978004438	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
693978004439	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
693978004440	Walker A/P-loop; other site
693978004441	ATP binding site [chemical binding]; other site
693978004442	Q-loop/lid; other site
693978004443	ABC transporter signature motif; other site
693978004444	Walker B; other site
693978004445	D-loop; other site
693978004446	H-loop/switch region; other site
693978004447	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
693978004448	NosL; Region: NosL; cl01769
693978004449	nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246
693978004450	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
693978004451	Cytochrome c; Region: Cytochrom_C; cl11414
693978004452	Cytochrome c; Region: Cytochrom_C; cl11414
693978004453	Domain of unknown function DUF77; Region: DUF77; cl00307
693978004454	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
693978004455	ligand binding site [chemical binding]; other site
693978004456	flexible hinge region; other site
693978004457	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
693978004458	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
693978004459	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
693978004460	Predicted transcriptional regulator [Transcription]; Region: COG1959
693978004461	Helix-turn-helix domains; Region: HTH; cl00088
693978004462	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
693978004463	ApbE family; Region: ApbE; cl00643
693978004464	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
693978004465	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
693978004466	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
693978004467	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
693978004468	FAD binding pocket [chemical binding]; other site
693978004469	conserved FAD binding motif [chemical binding]; other site
693978004470	phosphate binding motif [ion binding]; other site
693978004471	beta-alpha-beta structure motif; other site
693978004472	NAD binding pocket [chemical binding]; other site
693978004473	FlgD Ig-like domain; Region: FlgD_ig; cl15790
693978004474	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
693978004475	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
693978004476	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
693978004477	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
693978004478	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
693978004479	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
693978004480	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
693978004481	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978004482	Thioesterase domain; Region: Thioesterase; pfam00975
693978004483	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
693978004484	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
693978004485	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
693978004486	Helix-turn-helix domains; Region: HTH; cl00088
693978004487	PspC domain; Region: PspC; cl00864
693978004488	Invasion gene expression up-regulator, SirB; Region: SirB; cl01184
693978004489	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
693978004490	putative acyl-acceptor binding pocket; other site
693978004491	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
693978004492	CoenzymeA binding site [chemical binding]; other site
693978004493	subunit interaction site [polypeptide binding]; other site
693978004494	PHB binding site; other site
693978004495	chorismate binding enzyme; Region: Chorismate_bind; cl10555
693978004496	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
693978004497	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
693978004498	ligand binding site [chemical binding]; other site
693978004499	flexible hinge region; other site
693978004500	Helix-turn-helix domains; Region: HTH; cl00088
693978004501	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
693978004502	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
693978004503	Walker A/P-loop; other site
693978004504	ATP binding site [chemical binding]; other site
693978004505	Q-loop/lid; other site
693978004506	ABC transporter signature motif; other site
693978004507	Walker B; other site
693978004508	D-loop; other site
693978004509	H-loop/switch region; other site
693978004510	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
693978004511	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
693978004512	Thiamine pyrophosphokinase; Region: TPK; cd07995
693978004513	active site
693978004514	dimerization interface [polypeptide binding]; other site
693978004515	thiamine binding site [chemical binding]; other site
693978004516	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
693978004517	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
693978004518	dimer interface [polypeptide binding]; other site
693978004519	active site
693978004520	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
693978004521	catalytic residues [active]
693978004522	substrate binding site [chemical binding]; other site
693978004523	Arginase family; Region: Arginase; cl00306
693978004524	Protein of unknown function (DUF1304); Region: DUF1304; cl01533
693978004525	Protein of unknown function (DUF419); Region: DUF419; cl15265
693978004526	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
693978004527	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
693978004528	active site
693978004529	Riboflavin kinase; Region: Flavokinase; cl03312
693978004530	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
693978004531	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
693978004532	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
693978004533	alpha subunit interaction interface [polypeptide binding]; other site
693978004534	Walker A motif; other site
693978004535	ATP binding site [chemical binding]; other site
693978004536	Walker B motif; other site
693978004537	inhibitor binding site; inhibition site
693978004538	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
693978004539	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
693978004540	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
693978004541	active site
693978004542	multimer interface [polypeptide binding]; other site
693978004543	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
693978004544	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
693978004545	homodimer interface [polypeptide binding]; other site
693978004546	substrate-cofactor binding pocket; other site
693978004547	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978004548	catalytic residue [active]
693978004549	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
693978004550	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
693978004551	ligand binding site [chemical binding]; other site
693978004552	active site
693978004553	UGI interface [polypeptide binding]; other site
693978004554	catalytic site [active]
693978004555	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
693978004556	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
693978004557	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
693978004558	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
693978004559	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
693978004560	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
693978004561	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
693978004562	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
693978004563	catalytic residue [active]
693978004564	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
693978004565	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
693978004566	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
693978004567	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
693978004568	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
693978004569	inhibitor-cofactor binding pocket; inhibition site
693978004570	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978004571	catalytic residue [active]
693978004572	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
693978004573	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
693978004574	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
693978004575	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
693978004576	GAF domain; Region: GAF; cl15785
693978004577	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
693978004578	HIRAN domain; Region: HIRAN; cl07418
693978004579	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
693978004580	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693978004581	ATP binding site [chemical binding]; other site
693978004582	putative Mg++ binding site [ion binding]; other site
693978004583	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
693978004584	HsdM N-terminal domain; Region: HsdM_N; pfam12161
693978004585	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
693978004586	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
693978004587	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
693978004588	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
693978004589	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
693978004590	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
693978004591	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
693978004592	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
693978004593	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693978004594	ATP binding site [chemical binding]; other site
693978004595	putative Mg++ binding site [ion binding]; other site
693978004596	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978004597	nucleotide binding region [chemical binding]; other site
693978004598	ATP-binding site [chemical binding]; other site
693978004599	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
693978004600	putative catalytic site [active]
693978004601	putative metal binding site [ion binding]; other site
693978004602	putative phosphate binding site [ion binding]; other site
693978004603	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577
693978004604	putative active site [active]
693978004605	catalytic site [active]
693978004606	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
693978004607	active site
693978004608	dimer interface [polypeptide binding]; other site
693978004609	starch binding outer membrane protein SusD; Region: SusD; cl15876
693978004610	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693978004611	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978004612	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978004613	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
693978004614	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
693978004615	putative active site [active]
693978004616	putative metal binding site [ion binding]; other site
693978004617	PA14 domain; Region: PA14; cl08459
693978004618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693978004619	putative substrate translocation pore; other site
693978004620	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
693978004621	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978004622	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
693978004623	intersubunit interface [polypeptide binding]; other site
693978004624	active site
693978004625	catalytic residue [active]
693978004626	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
693978004627	E3 interaction surface; other site
693978004628	lipoyl attachment site [posttranslational modification]; other site
693978004629	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
693978004630	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
693978004631	E3 interaction surface; other site
693978004632	lipoyl attachment site [posttranslational modification]; other site
693978004633	e3 binding domain; Region: E3_binding; pfam02817
693978004634	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
693978004635	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
693978004636	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
693978004637	tetramer interface [polypeptide binding]; other site
693978004638	TPP-binding site [chemical binding]; other site
693978004639	heterodimer interface [polypeptide binding]; other site
693978004640	phosphorylation loop region [posttranslational modification]
693978004641	Predicted transcriptional regulator [Transcription]; Region: COG2378
693978004642	WYL domain; Region: WYL; cl14852
693978004643	Spore germination protein; Region: Spore_permease; cl15802
693978004644	amino acid transporter; Region: 2A0306; TIGR00909
693978004645	Spore germination protein; Region: Spore_permease; cl15802
693978004646	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
693978004647	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693978004648	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
693978004649	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978004650	starch binding outer membrane protein SusD; Region: SusD; cl15876
693978004651	Domain of unknown function (DUF4302); Region: DUF4302; pfam14135
693978004652	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978004653	Imelysin; Region: Peptidase_M75; cl09159
693978004654	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
693978004655	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
693978004656	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693978004657	N-terminal plug; other site
693978004658	ligand-binding site [chemical binding]; other site
693978004659	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
693978004660	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
693978004661	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
693978004662	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
693978004663	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
693978004664	TraB family; Region: TraB; cl12050
693978004665	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
693978004666	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
693978004667	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
693978004668	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
693978004669	DinB superfamily; Region: DinB_2; pfam12867
693978004670	MoxR-like ATPases [General function prediction only]; Region: COG0714
693978004671	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978004672	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
693978004673	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
693978004674	metal ion-dependent adhesion site (MIDAS); other site
693978004675	Oxygen tolerance; Region: BatD; pfam13584
693978004676	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
693978004677	metal ion-dependent adhesion site (MIDAS); other site
693978004678	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
693978004679	metal ion-dependent adhesion site (MIDAS); other site
693978004680	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693978004681	binding surface
693978004682	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693978004683	TPR motif; other site
693978004684	TPR repeat; Region: TPR_11; pfam13414
693978004685	Oxygen tolerance; Region: BatD; pfam13584
693978004686	MarC family integral membrane protein; Region: MarC; cl00919
693978004687	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
693978004688	active site
693978004689	dimer interface [polypeptide binding]; other site
693978004690	metal binding site [ion binding]; metal-binding site
693978004691	Proline dehydrogenase; Region: Pro_dh; cl03282
693978004692	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
693978004693	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
693978004694	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
693978004695	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
693978004696	substrate binding pocket [chemical binding]; other site
693978004697	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
693978004698	B12 binding site [chemical binding]; other site
693978004699	cobalt ligand [ion binding]; other site
693978004700	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
693978004701	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
693978004702	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
693978004703	FAD binding site [chemical binding]; other site
693978004704	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
693978004705	active site
693978004706	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
693978004707	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
693978004708	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
693978004709	catalytic residue [active]
693978004710	AAA domain; Region: AAA_26; pfam13500
693978004711	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978004712	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
693978004713	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
693978004714	inhibitor-cofactor binding pocket; inhibition site
693978004715	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693978004716	catalytic residue [active]
693978004717	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
693978004718	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
693978004719	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
693978004720	16S rRNA methyltransferase B; Provisional; Region: PRK14902
693978004721	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693978004722	S-adenosylmethionine binding site [chemical binding]; other site
693978004723	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
693978004724	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
693978004725	active site
693978004726	NTP binding site [chemical binding]; other site
693978004727	metal binding triad [ion binding]; metal-binding site
693978004728	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
693978004729	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
693978004730	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
693978004731	aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340
693978004732	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584
693978004733	substrate binding site [chemical binding]; other site
693978004734	ligand binding site [chemical binding]; other site
693978004735	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
693978004736	substrate binding site [chemical binding]; other site
693978004737	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978004738	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
693978004739	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978004740	DNA-directed RNA polymerase, subunit A''; Region: RNA_pol_rpoA2; TIGR02389
693978004741	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
693978004742	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
693978004743	Helix-turn-helix domain; Region: HTH_18; pfam12833
693978004744	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693978004745	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
693978004746	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
693978004747	metal-binding site [ion binding]
693978004748	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
693978004749	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
693978004750	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
693978004751	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
693978004752	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
693978004753	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693978004754	non-specific DNA binding site [nucleotide binding]; other site
693978004755	salt bridge; other site
693978004756	sequence-specific DNA binding site [nucleotide binding]; other site
693978004757	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
693978004758	Cation efflux family; Region: Cation_efflux; cl00316
693978004759	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
693978004760	synthetase active site [active]
693978004761	NTP binding site [chemical binding]; other site
693978004762	metal binding site [ion binding]; metal-binding site
693978004763	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
693978004764	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693978004765	non-specific DNA binding site [nucleotide binding]; other site
693978004766	salt bridge; other site
693978004767	sequence-specific DNA binding site [nucleotide binding]; other site
693978004768	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
693978004769	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
693978004770	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
693978004771	DpnII restriction endonuclease; Region: DpnII; pfam04556
693978004772	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
693978004773	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978004774	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
693978004775	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
693978004776	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
693978004777	oligomeric interface; other site
693978004778	putative active site [active]
693978004779	homodimer interface [polypeptide binding]; other site
693978004780	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
693978004781	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
693978004782	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
693978004783	Restriction endonuclease; Region: Mrr_cat; cl00516
693978004784	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
693978004785	metal binding triad [ion binding]; metal-binding site
693978004786	TIR domain; Region: TIR_2; cl15770
693978004787	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
693978004788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978004789	Walker A motif; other site
693978004790	ATP binding site [chemical binding]; other site
693978004791	Walker B motif; other site
693978004792	arginine finger; other site
693978004793	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
693978004794	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
693978004795	Clp protease; Region: CLP_protease; pfam00574
693978004796	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
693978004797	oligomer interface [polypeptide binding]; other site
693978004798	active site residues [active]
693978004799	DNA primase, catalytic core; Region: dnaG; TIGR01391
693978004800	CHC2 zinc finger; Region: zf-CHC2; cl15369
693978004801	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
693978004802	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
693978004803	active site
693978004804	metal binding site [ion binding]; metal-binding site
693978004805	interdomain interaction site; other site
693978004806	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
693978004807	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
693978004808	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
693978004809	peptide chain release factor 2; Validated; Region: prfB; PRK00578
693978004810	RF-1 domain; Region: RF-1; cl02875
693978004811	RF-1 domain; Region: RF-1; cl02875
693978004812	multidrug efflux protein; Reviewed; Region: PRK01766
693978004813	MatE; Region: MatE; cl10513
693978004814	MatE; Region: MatE; cl10513
693978004815	Response regulator receiver domain; Region: Response_reg; pfam00072
693978004816	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693978004817	active site
693978004818	phosphorylation site [posttranslational modification]
693978004819	intermolecular recognition site; other site
693978004820	dimerization interface [polypeptide binding]; other site
693978004821	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978004822	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
693978004823	Walker A motif; other site
693978004824	ATP binding site [chemical binding]; other site
693978004825	Walker B motif; other site
693978004826	arginine finger; other site
693978004827	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
693978004828	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
693978004829	catalytic residue [active]
693978004830	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
693978004831	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
693978004832	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
693978004833	Haemolytic domain; Region: Haemolytic; cl00506
693978004834	recombination factor protein RarA; Reviewed; Region: PRK13342
693978004835	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693978004836	Walker A motif; other site
693978004837	ATP binding site [chemical binding]; other site
693978004838	Walker B motif; other site
693978004839	arginine finger; other site
693978004840	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
693978004841	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
693978004842	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
693978004843	putative acyl-acceptor binding pocket; other site
693978004844	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
693978004845	putative active site [active]
693978004846	putative CoA binding site [chemical binding]; other site
693978004847	nudix motif; other site
693978004848	metal binding site [ion binding]; metal-binding site
693978004849	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
693978004850	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978004851	NAD(P) binding pocket [chemical binding]; other site
693978004852	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
693978004853	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
693978004854	Cation transport protein; Region: TrkH; cl10514
693978004855	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978004856	Prephenate dehydrogenase; Region: PDH; pfam02153
693978004857	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
693978004858	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
693978004859	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
693978004860	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978004861	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
693978004862	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
693978004863	active site
693978004864	lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598
693978004865	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
693978004866	Sulfatase; Region: Sulfatase; cl10460
693978004867	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
693978004868	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
693978004869	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
693978004870	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
693978004871	Walker A/P-loop; other site
693978004872	ATP binding site [chemical binding]; other site
693978004873	Q-loop/lid; other site
693978004874	ABC transporter signature motif; other site
693978004875	Walker B; other site
693978004876	D-loop; other site
693978004877	H-loop/switch region; other site
693978004878	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
693978004879	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978004880	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
693978004881	NeuB family; Region: NeuB; cl00496
693978004882	Methyltransferase domain; Region: Methyltransf_31; pfam13847
693978004883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693978004884	S-adenosylmethionine binding site [chemical binding]; other site
693978004885	Protein of unknown function (DUF3822); Region: DUF3822; pfam12864
693978004886	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
693978004887	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978004888	NAD(P) binding site [chemical binding]; other site
693978004889	active site
693978004890	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
693978004891	Ligand binding site [chemical binding]; other site
693978004892	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
693978004893	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
693978004894	Ligand binding site [chemical binding]; other site
693978004895	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
693978004896	Bifunctional nuclease; Region: DNase-RNase; cl00553
693978004897	nucleoside transporter; Region: 2A0110; TIGR00889
693978004898	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693978004899	putative substrate translocation pore; other site
693978004900	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
693978004901	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693978004902	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693978004903	DNA binding residues [nucleotide binding]
693978004904	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
693978004905	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
693978004906	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
693978004907	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693978004908	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
693978004909	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
693978004910	Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679
693978004911	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
693978004912	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
693978004913	H+ Antiporter protein; Region: 2A0121; TIGR00900
693978004914	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693978004915	putative substrate translocation pore; other site
693978004916	GH3 auxin-responsive promoter; Region: GH3; cl04006
693978004917	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
693978004918	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
693978004919	CrcB-like protein; Region: CRCB; cl09114
693978004920	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693978004921	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
693978004922	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693978004923	non-specific DNA binding site [nucleotide binding]; other site
693978004924	salt bridge; other site
693978004925	sequence-specific DNA binding site [nucleotide binding]; other site
693978004926	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
693978004927	active site
693978004928	metal binding site [ion binding]; metal-binding site
693978004929	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
693978004930	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
693978004931	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
693978004932	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912
693978004933	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
693978004934	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
693978004935	Mu-like prophage protein [General function prediction only]; Region: COG3941
693978004936	chromosome segregation protein; Provisional; Region: PRK03918
693978004937	Abi-like protein; Region: Abi_2; cl01988
693978004938	AntA/AntB antirepressor; Region: AntA; cl01430
693978004939	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
693978004940	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
693978004941	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
693978004942	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
693978004943	Phage terminase large subunit; Region: Terminase_3; cl12054
693978004944	Terminase-like family; Region: Terminase_6; pfam03237
693978004945	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
693978004946	Ligand Binding Site [chemical binding]; other site
693978004947	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
693978004948	Protein of unknown function (DUF2693); Region: DUF2693; pfam10902
693978004949	AntA/AntB antirepressor; Region: AntA; cl01430
693978004950	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
693978004951	BRO family, N-terminal domain; Region: Bro-N; cl10591
693978004952	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540
693978004953	putative metal binding site [ion binding]; other site
693978004954	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
693978004955	Ligand Binding Site [chemical binding]; other site
693978004956	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
693978004957	Helix-turn-helix domains; Region: HTH; cl00088
693978004958	Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752
693978004959	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
693978004960	ERF superfamily; Region: ERF; pfam04404
693978004961	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
693978004962	lysine-specific histone demethylase 1 homolog; Region: PLN02328
693978004963	ribosome recycling factor; Reviewed; Region: frr; PRK00083
693978004964	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
693978004965	hinge region; other site
693978004966	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
693978004967	putative nucleotide binding site [chemical binding]; other site
693978004968	uridine monophosphate binding site [chemical binding]; other site
693978004969	homohexameric interface [polypeptide binding]; other site
693978004970	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
693978004971	RNA binding site [nucleotide binding]; other site
693978004972	active site
693978004973	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
693978004974	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
693978004975	RNA binding surface [nucleotide binding]; other site
693978004976	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
693978004977	probable active site [active]
693978004978	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
693978004979	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
693978004980	amino acid transporter; Region: 2A0306; TIGR00909
693978004981	Spore germination protein; Region: Spore_permease; cl15802
693978004982	Spore germination protein; Region: Spore_permease; cl15802
693978004983	FlgD Ig-like domain; Region: FlgD_ig; cl15790
693978004984	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
693978004985	active site pocket [active]
693978004986	oxyanion hole [active]
693978004987	catalytic triad [active]
693978004988	active site nucleophile [active]
693978004989	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
693978004990	active site