-- dump date   	20140620_035333
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1271752000001	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
1271752000002	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
1271752000003	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1271752000004	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1271752000005	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1271752000006	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
1271752000007	putative dimer interface [polypeptide binding]; other site
1271752000008	putative anticodon binding site; other site
1271752000009	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1271752000010	homodimer interface [polypeptide binding]; other site
1271752000011	motif 1; other site
1271752000012	motif 2; other site
1271752000013	active site
1271752000014	motif 3; other site
1271752000015	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1271752000016	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1271752000017	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1271752000018	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752000019	WYL domain; Region: WYL; pfam13280
1271752000020	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1271752000021	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1271752000022	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
1271752000023	PLD-like domain; Region: PLDc_2; pfam13091
1271752000024	putative active site [active]
1271752000025	catalytic site [active]
1271752000026	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
1271752000027	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1271752000028	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1271752000029	VanZ like family; Region: VanZ; cl01971
1271752000030	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1271752000031	lipoyl attachment site [posttranslational modification]; other site
1271752000032	Dihydroneopterin aldolase; Region: FolB; pfam02152
1271752000033	active site
1271752000034	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1271752000035	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1271752000036	catalytic site [active]
1271752000037	G-X2-G-X-G-K; other site
1271752000038	hypothetical protein; Provisional; Region: PRK11820
1271752000039	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1271752000040	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1271752000041	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1271752000042	enoyl-CoA hydratase; Provisional; Region: PRK08140
1271752000043	substrate binding site [chemical binding]; other site
1271752000044	oxyanion hole (OAH) forming residues; other site
1271752000045	trimer interface [polypeptide binding]; other site
1271752000046	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1271752000047	active site
1271752000048	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1271752000049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1271752000050	Walker A/P-loop; other site
1271752000051	ATP binding site [chemical binding]; other site
1271752000052	Q-loop/lid; other site
1271752000053	ABC transporter signature motif; other site
1271752000054	Walker B; other site
1271752000055	D-loop; other site
1271752000056	H-loop/switch region; other site
1271752000057	ABC transporter; Region: ABC_tran_2; pfam12848
1271752000058	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1271752000059	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1271752000060	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752000061	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
1271752000062	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1271752000063	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1271752000064	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1271752000065	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1271752000066	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1271752000067	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1271752000068	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1271752000069	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1271752000070	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1271752000071	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1271752000072	DNA binding site [nucleotide binding]
1271752000073	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1271752000074	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1271752000075	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1271752000076	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1271752000077	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1271752000078	RPB11 interaction site [polypeptide binding]; other site
1271752000079	RPB12 interaction site [polypeptide binding]; other site
1271752000080	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1271752000081	RPB3 interaction site [polypeptide binding]; other site
1271752000082	RPB1 interaction site [polypeptide binding]; other site
1271752000083	RPB11 interaction site [polypeptide binding]; other site
1271752000084	RPB10 interaction site [polypeptide binding]; other site
1271752000085	Thrombospondin type 3 repeat; Region: TSP_3; pfam02412
1271752000086	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1271752000087	peripheral dimer interface [polypeptide binding]; other site
1271752000088	core dimer interface [polypeptide binding]; other site
1271752000089	L10 interface [polypeptide binding]; other site
1271752000090	L11 interface [polypeptide binding]; other site
1271752000091	putative EF-Tu interaction site [polypeptide binding]; other site
1271752000092	putative EF-G interaction site [polypeptide binding]; other site
1271752000093	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1271752000094	23S rRNA interface [nucleotide binding]; other site
1271752000095	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1271752000096	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1271752000097	mRNA/rRNA interface [nucleotide binding]; other site
1271752000098	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1271752000099	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1271752000100	23S rRNA interface [nucleotide binding]; other site
1271752000101	L7/L12 interface [polypeptide binding]; other site
1271752000102	putative thiostrepton binding site; other site
1271752000103	L25 interface [polypeptide binding]; other site
1271752000104	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1271752000105	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1271752000106	putative homodimer interface [polypeptide binding]; other site
1271752000107	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1271752000108	heterodimer interface [polypeptide binding]; other site
1271752000109	homodimer interface [polypeptide binding]; other site
1271752000110	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
1271752000111	elongation factor Tu; Reviewed; Region: PRK12735
1271752000112	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1271752000113	GEF interaction site [polypeptide binding]; other site
1271752000114	GTP/Mg2+ binding site [chemical binding]; other site
1271752000115	Switch I region; other site
1271752000116	G2 box; other site
1271752000117	G3 box; other site
1271752000118	Switch II region; other site
1271752000119	G4 box; other site
1271752000120	G5 box; other site
1271752000121	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1271752000122	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1271752000123	Antibiotic Binding Site [chemical binding]; other site
1271752000124	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1271752000125	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1271752000126	quinone interaction residues [chemical binding]; other site
1271752000127	active site
1271752000128	catalytic residues [active]
1271752000129	FMN binding site [chemical binding]; other site
1271752000130	substrate binding site [chemical binding]; other site
1271752000131	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1271752000132	30S subunit binding site; other site
1271752000133	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1271752000134	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1271752000135	active site
1271752000136	DNA binding site [nucleotide binding]
1271752000137	Int/Topo IB signature motif; other site
1271752000138	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1271752000139	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1271752000140	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1271752000141	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1271752000142	active site
1271752000143	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1271752000144	active site
1271752000145	oligomerization interface [polypeptide binding]; other site
1271752000146	metal binding site [ion binding]; metal-binding site
1271752000147	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1271752000148	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1271752000149	ligand binding site [chemical binding]; other site
1271752000150	flexible hinge region; other site
1271752000151	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1271752000152	non-specific DNA interactions [nucleotide binding]; other site
1271752000153	DNA binding site [nucleotide binding]
1271752000154	sequence specific DNA binding site [nucleotide binding]; other site
1271752000155	putative cAMP binding site [chemical binding]; other site
1271752000156	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
1271752000157	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1271752000158	Heavy-metal-associated domain; Region: HMA; pfam00403
1271752000159	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1271752000160	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1271752000161	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
1271752000162	putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485
1271752000163	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
1271752000164	Low-spin heme binding site [chemical binding]; other site
1271752000165	Putative water exit pathway; other site
1271752000166	Binuclear center (active site) [active]
1271752000167	Putative proton exit pathway; other site
1271752000168	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
1271752000169	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
1271752000170	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
1271752000171	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1271752000172	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
1271752000173	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1271752000174	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
1271752000175	FixH; Region: FixH; pfam05751
1271752000176	Family description; Region: DsbD_2; pfam13386
1271752000177	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1271752000178	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1271752000179	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1271752000180	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
1271752000181	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
1271752000182	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
1271752000183	active site
1271752000184	catalytic site [active]
1271752000185	substrate binding site [chemical binding]; other site
1271752000186	Domain of unknown function DUF59; Region: DUF59; cl00941
1271752000187	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1271752000188	23S rRNA interface [nucleotide binding]; other site
1271752000189	L3 interface [polypeptide binding]; other site
1271752000190	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1271752000191	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1271752000192	rRNA interaction site [nucleotide binding]; other site
1271752000193	S8 interaction site; other site
1271752000194	putative laminin-1 binding site; other site
1271752000195	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1271752000196	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1271752000197	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752000198	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752000199	Phytase; Region: Phytase; cl17685
1271752000200	transcription termination factor Rho; Provisional; Region: PRK12608
1271752000201	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1271752000202	RNA binding site [nucleotide binding]; other site
1271752000203	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1271752000204	multimer interface [polypeptide binding]; other site
1271752000205	Walker A motif; other site
1271752000206	ATP binding site [chemical binding]; other site
1271752000207	Walker B motif; other site
1271752000208	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
1271752000209	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1271752000210	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1271752000211	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1271752000212	Walker A/P-loop; other site
1271752000213	ATP binding site [chemical binding]; other site
1271752000214	Q-loop/lid; other site
1271752000215	ABC transporter signature motif; other site
1271752000216	Walker B; other site
1271752000217	D-loop; other site
1271752000218	H-loop/switch region; other site
1271752000219	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1271752000220	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1271752000221	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1271752000222	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1271752000223	active site
1271752000224	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
1271752000225	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
1271752000226	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
1271752000227	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1271752000228	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1271752000229	putative NAD(P) binding site [chemical binding]; other site
1271752000230	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1271752000231	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1271752000232	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
1271752000233	Restriction endonuclease EcoRI; Region: EcoRI; pfam02963
1271752000234	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752000235	Predicted membrane protein [Function unknown]; Region: COG2246
1271752000236	GtrA-like protein; Region: GtrA; pfam04138
1271752000237	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1271752000238	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1271752000239	putative acyl-acceptor binding pocket; other site
1271752000240	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1271752000241	L-fucose transporter; Provisional; Region: PRK10133; cl17665
1271752000242	L-fucose transporter; Provisional; Region: PRK10133; cl17665
1271752000243	Protein of unknown function (DUF3810); Region: DUF3810; pfam12725
1271752000244	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1271752000245	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
1271752000246	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
1271752000247	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1271752000248	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1271752000249	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1271752000250	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1271752000251	dimerization interface [polypeptide binding]; other site
1271752000252	active site
1271752000253	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
1271752000254	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
1271752000255	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1271752000256	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1271752000257	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1271752000258	Peptidase family M23; Region: Peptidase_M23; pfam01551
1271752000259	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
1271752000260	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
1271752000261	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1271752000262	active site
1271752000263	Substrate binding site; other site
1271752000264	Mg++ binding site; other site
1271752000265	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1271752000266	putative trimer interface [polypeptide binding]; other site
1271752000267	putative CoA binding site [chemical binding]; other site
1271752000268	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1271752000269	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1271752000270	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1271752000271	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1271752000272	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1271752000273	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1271752000274	active site
1271752000275	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1271752000276	trimer interface [polypeptide binding]; other site
1271752000277	active site
1271752000278	substrate binding site [chemical binding]; other site
1271752000279	CoA binding site [chemical binding]; other site
1271752000280	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1271752000281	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1271752000282	active site
1271752000283	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1271752000284	active site
1271752000285	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
1271752000286	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1271752000287	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1271752000288	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1271752000289	active site
1271752000290	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1271752000291	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1271752000292	UDP-galactopyranose mutase; Region: GLF; pfam03275
1271752000293	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
1271752000294	GTP cyclohydrolase I; Provisional; Region: PLN03044
1271752000295	active site
1271752000296	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1271752000297	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1271752000298	active site
1271752000299	HIGH motif; other site
1271752000300	nucleotide binding site [chemical binding]; other site
1271752000301	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1271752000302	KMSKS motif; other site
1271752000303	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1271752000304	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1271752000305	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1271752000306	NAD(P) binding site [chemical binding]; other site
1271752000307	active site
1271752000308	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1271752000309	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1271752000310	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1271752000311	Preprotein translocase subunit; Region: YajC; pfam02699
1271752000312	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
1271752000313	transcription antitermination factor NusB; Region: nusB; TIGR01951
1271752000314	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1271752000315	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1271752000316	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1271752000317	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1271752000318	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1271752000319	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1271752000320	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1271752000321	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1271752000322	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1271752000323	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1271752000324	dimerization interface [polypeptide binding]; other site
1271752000325	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1271752000326	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1271752000327	tetramer interface [polypeptide binding]; other site
1271752000328	heme binding pocket [chemical binding]; other site
1271752000329	NADPH binding site [chemical binding]; other site
1271752000330	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1271752000331	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1271752000332	active site
1271752000333	catalytic tetrad [active]
1271752000334	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1271752000335	enoyl-CoA hydratase; Provisional; Region: PRK07658
1271752000336	substrate binding site [chemical binding]; other site
1271752000337	oxyanion hole (OAH) forming residues; other site
1271752000338	trimer interface [polypeptide binding]; other site
1271752000339	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1271752000340	catalytic motif [active]
1271752000341	Zn binding site [ion binding]; other site
1271752000342	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1271752000343	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1271752000344	active site
1271752000345	DNA binding site [nucleotide binding]
1271752000346	Int/Topo IB signature motif; other site
1271752000347	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1271752000348	nudix motif; other site
1271752000349	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1271752000350	Ferritin-like domain; Region: Ferritin; pfam00210
1271752000351	ferroxidase diiron center [ion binding]; other site
1271752000352	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1271752000353	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752000354	Walker A motif; other site
1271752000355	ATP binding site [chemical binding]; other site
1271752000356	Walker B motif; other site
1271752000357	arginine finger; other site
1271752000358	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1271752000359	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1271752000360	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1271752000361	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1271752000362	CoA-binding site [chemical binding]; other site
1271752000363	ATP-binding [chemical binding]; other site
1271752000364	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1271752000365	Cation efflux family; Region: Cation_efflux; pfam01545
1271752000366	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1271752000367	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1271752000368	GIY-YIG motif/motif A; other site
1271752000369	active site
1271752000370	catalytic site [active]
1271752000371	putative DNA binding site [nucleotide binding]; other site
1271752000372	metal binding site [ion binding]; metal-binding site
1271752000373	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1271752000374	VanZ like family; Region: VanZ; pfam04892
1271752000375	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1271752000376	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1271752000377	putative active site [active]
1271752000378	catalytic triad [active]
1271752000379	putative dimer interface [polypeptide binding]; other site
1271752000380	Phosphotransferase enzyme family; Region: APH; pfam01636
1271752000381	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
1271752000382	AAA domain; Region: AAA_30; pfam13604
1271752000383	AAA domain; Region: AAA_22; pfam13401
1271752000384	Family description; Region: UvrD_C_2; pfam13538
1271752000385	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1271752000386	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1271752000387	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1271752000388	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1271752000389	trimer interface [polypeptide binding]; other site
1271752000390	putative metal binding site [ion binding]; other site
1271752000391	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
1271752000392	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
1271752000393	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1271752000394	ferrochelatase; Reviewed; Region: hemH; PRK00035
1271752000395	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1271752000396	C-terminal domain interface [polypeptide binding]; other site
1271752000397	active site
1271752000398	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1271752000399	active site
1271752000400	N-terminal domain interface [polypeptide binding]; other site
1271752000401	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1271752000402	NAD(P) binding site [chemical binding]; other site
1271752000403	active site
1271752000404	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752000405	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752000406	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752000407	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752000408	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752000409	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1271752000410	elongation factor G; Reviewed; Region: PRK12739
1271752000411	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1271752000412	G1 box; other site
1271752000413	putative GEF interaction site [polypeptide binding]; other site
1271752000414	GTP/Mg2+ binding site [chemical binding]; other site
1271752000415	Switch I region; other site
1271752000416	G2 box; other site
1271752000417	G3 box; other site
1271752000418	Switch II region; other site
1271752000419	G4 box; other site
1271752000420	G5 box; other site
1271752000421	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1271752000422	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1271752000423	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1271752000424	30S ribosomal protein S7; Validated; Region: PRK05302
1271752000425	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1271752000426	S17 interaction site [polypeptide binding]; other site
1271752000427	S8 interaction site; other site
1271752000428	16S rRNA interaction site [nucleotide binding]; other site
1271752000429	streptomycin interaction site [chemical binding]; other site
1271752000430	23S rRNA interaction site [nucleotide binding]; other site
1271752000431	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1271752000432	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1271752000433	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1271752000434	dimerization interface [polypeptide binding]; other site
1271752000435	DPS ferroxidase diiron center [ion binding]; other site
1271752000436	ion pore; other site
1271752000437	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
1271752000438	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
1271752000439	active site
1271752000440	RmuC family; Region: RmuC; pfam02646
1271752000441	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1271752000442	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1271752000443	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
1271752000444	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1271752000445	Coenzyme A binding pocket [chemical binding]; other site
1271752000446	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1271752000447	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
1271752000448	dimer interface [polypeptide binding]; other site
1271752000449	active site
1271752000450	heme binding site [chemical binding]; other site
1271752000451	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1271752000452	Flagellin N-methylase; Region: FliB; pfam03692
1271752000453	bZIP Maf transcription factor; Region: bZIP_Maf; pfam03131
1271752000454	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1271752000455	non-specific DNA binding site [nucleotide binding]; other site
1271752000456	sequence-specific DNA binding site [nucleotide binding]; other site
1271752000457	salt bridge; other site
1271752000458	AAA domain; Region: AAA_22; pfam13401
1271752000459	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1271752000460	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1271752000461	Walker A motif; other site
1271752000462	ATP binding site [chemical binding]; other site
1271752000463	Walker B motif; other site
1271752000464	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054
1271752000465	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
1271752000466	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1271752000467	Protein of unknown function (DUF935); Region: DUF935; pfam06074
1271752000468	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
1271752000469	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1271752000470	salt bridge; other site
1271752000471	non-specific DNA binding site [nucleotide binding]; other site
1271752000472	sequence-specific DNA binding site [nucleotide binding]; other site
1271752000473	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
1271752000474	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1271752000475	amidase catalytic site [active]
1271752000476	Zn binding residues [ion binding]; other site
1271752000477	substrate binding site [chemical binding]; other site
1271752000478	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1271752000479	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1271752000480	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1271752000481	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1271752000482	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1271752000483	catalytic residue [active]
1271752000484	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1271752000485	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1271752000486	motif 1; other site
1271752000487	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1271752000488	active site
1271752000489	motif 2; other site
1271752000490	motif 3; other site
1271752000491	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1271752000492	anticodon binding site; other site
1271752000493	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1271752000494	active site
1271752000495	metal binding site [ion binding]; metal-binding site
1271752000496	peptidase T; Region: peptidase-T; TIGR01882
1271752000497	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1271752000498	metal binding site [ion binding]; metal-binding site
1271752000499	dimer interface [polypeptide binding]; other site
1271752000500	fumarate hydratase; Provisional; Region: PRK15389
1271752000501	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1271752000502	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1271752000503	Phosphate transporter family; Region: PHO4; pfam01384
1271752000504	Phosphate transporter family; Region: PHO4; cl00396
1271752000505	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
1271752000506	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752000507	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1271752000508	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1271752000509	ligand binding site [chemical binding]; other site
1271752000510	flexible hinge region; other site
1271752000511	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1271752000512	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1271752000513	tRNA; other site
1271752000514	putative tRNA binding site [nucleotide binding]; other site
1271752000515	putative NADP binding site [chemical binding]; other site
1271752000516	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1271752000517	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1271752000518	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
1271752000519	domain interfaces; other site
1271752000520	active site
1271752000521	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1271752000522	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1271752000523	active site
1271752000524	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
1271752000525	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1271752000526	substrate binding site [chemical binding]; other site
1271752000527	active site
1271752000528	bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191
1271752000529	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1271752000530	Coenzyme A binding pocket [chemical binding]; other site
1271752000531	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
1271752000532	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1271752000533	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1271752000534	N-terminal plug; other site
1271752000535	ligand-binding site [chemical binding]; other site
1271752000536	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
1271752000537	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1271752000538	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1271752000539	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1271752000540	Bacterial SH3 domain; Region: SH3_3; cl17532
1271752000541	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1271752000542	NlpC/P60 family; Region: NLPC_P60; pfam00877
1271752000543	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1271752000544	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1271752000545	S-adenosylmethionine binding site [chemical binding]; other site
1271752000546	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1271752000547	ligand binding site [chemical binding]; other site
1271752000548	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1271752000549	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1271752000550	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1271752000551	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1271752000552	rod shape-determining protein MreC; Provisional; Region: PRK13922
1271752000553	rod shape-determining protein MreC; Region: MreC; pfam04085
1271752000554	rod shape-determining protein MreB; Provisional; Region: PRK13927
1271752000555	MreB and similar proteins; Region: MreB_like; cd10225
1271752000556	nucleotide binding site [chemical binding]; other site
1271752000557	Mg binding site [ion binding]; other site
1271752000558	putative protofilament interaction site [polypeptide binding]; other site
1271752000559	RodZ interaction site [polypeptide binding]; other site
1271752000560	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1271752000561	GTP-binding protein Der; Reviewed; Region: PRK00093
1271752000562	G1 box; other site
1271752000563	GTP/Mg2+ binding site [chemical binding]; other site
1271752000564	Switch I region; other site
1271752000565	G2 box; other site
1271752000566	Switch II region; other site
1271752000567	G3 box; other site
1271752000568	G4 box; other site
1271752000569	G5 box; other site
1271752000570	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1271752000571	G1 box; other site
1271752000572	GTP/Mg2+ binding site [chemical binding]; other site
1271752000573	Switch I region; other site
1271752000574	G2 box; other site
1271752000575	G3 box; other site
1271752000576	Switch II region; other site
1271752000577	G4 box; other site
1271752000578	G5 box; other site
1271752000579	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1271752000580	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1271752000581	nucleotide binding site [chemical binding]; other site
1271752000582	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1271752000583	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752000584	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
1271752000585	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1271752000586	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1271752000587	nucleotide binding region [chemical binding]; other site
1271752000588	ATP-binding site [chemical binding]; other site
1271752000589	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
1271752000590	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1271752000591	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1271752000592	NAD(P) binding site [chemical binding]; other site
1271752000593	active site
1271752000594	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1271752000595	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
1271752000596	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1271752000597	Flavoprotein; Region: Flavoprotein; pfam02441
1271752000598	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1271752000599	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1271752000600	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
1271752000601	Substrate binding site; other site
1271752000602	metal-binding site
1271752000603	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1271752000604	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1271752000605	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1271752000606	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1271752000607	active site
1271752000608	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1271752000609	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1271752000610	putative ATP binding site [chemical binding]; other site
1271752000611	putative substrate interface [chemical binding]; other site
1271752000612	Ribonuclease P; Region: Ribonuclease_P; pfam00825
1271752000613	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752000614	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1271752000615	Walker A motif; other site
1271752000616	ATP binding site [chemical binding]; other site
1271752000617	Walker B motif; other site
1271752000618	arginine finger; other site
1271752000619	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1271752000620	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329
1271752000621	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1271752000622	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1271752000623	FeS/SAM binding site; other site
1271752000624	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
1271752000625	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
1271752000626	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1271752000627	active site
1271752000628	thiamine-monophosphate kinase; Region: thiL; TIGR01379
1271752000629	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1271752000630	ATP binding site [chemical binding]; other site
1271752000631	dimerization interface [polypeptide binding]; other site
1271752000632	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752000633	biotin synthase; Region: bioB; TIGR00433
1271752000634	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1271752000635	FeS/SAM binding site; other site
1271752000636	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1271752000637	Protein of unknown function (DUF502); Region: DUF502; cl01107
1271752000638	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752000639	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1271752000640	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1271752000641	Walker A/P-loop; other site
1271752000642	ATP binding site [chemical binding]; other site
1271752000643	Q-loop/lid; other site
1271752000644	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
1271752000645	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1271752000646	Q-loop/lid; other site
1271752000647	ABC transporter signature motif; other site
1271752000648	Walker B; other site
1271752000649	D-loop; other site
1271752000650	H-loop/switch region; other site
1271752000651	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
1271752000652	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1271752000653	active site
1271752000654	catalytic site [active]
1271752000655	substrate binding site [chemical binding]; other site
1271752000656	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1271752000657	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1271752000658	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1271752000659	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1271752000660	active site residue [active]
1271752000661	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1271752000662	active site residue [active]
1271752000663	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1271752000664	active site residue [active]
1271752000665	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1271752000666	active site residue [active]
1271752000667	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1271752000668	catalytic residues [active]
1271752000669	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1271752000670	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1271752000671	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1271752000672	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1271752000673	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1271752000674	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1271752000675	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
1271752000676	ligand binding site [chemical binding]; other site
1271752000677	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
1271752000678	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
1271752000679	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
1271752000680	starch binding outer membrane protein SusD; Region: SusD; cd08977
1271752000681	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
1271752000682	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
1271752000683	translation initiation factor IF-2; Region: IF-2; TIGR00487
1271752000684	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1271752000685	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1271752000686	G1 box; other site
1271752000687	putative GEF interaction site [polypeptide binding]; other site
1271752000688	GTP/Mg2+ binding site [chemical binding]; other site
1271752000689	Switch I region; other site
1271752000690	G2 box; other site
1271752000691	G3 box; other site
1271752000692	Switch II region; other site
1271752000693	G4 box; other site
1271752000694	G5 box; other site
1271752000695	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1271752000696	Translation-initiation factor 2; Region: IF-2; pfam11987
1271752000697	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1271752000698	transcription termination factor NusA; Region: NusA; TIGR01953
1271752000699	NusA N-terminal domain; Region: NusA_N; pfam08529
1271752000700	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1271752000701	RNA binding site [nucleotide binding]; other site
1271752000702	homodimer interface [polypeptide binding]; other site
1271752000703	NusA-like KH domain; Region: KH_5; pfam13184
1271752000704	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1271752000705	G-X-X-G motif; other site
1271752000706	Sm and related proteins; Region: Sm_like; cl00259
1271752000707	heptamer interface [polypeptide binding]; other site
1271752000708	Sm1 motif; other site
1271752000709	hexamer interface [polypeptide binding]; other site
1271752000710	RNA binding site [nucleotide binding]; other site
1271752000711	Sm2 motif; other site
1271752000712	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1271752000713	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1271752000714	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
1271752000715	Active site serine [active]
1271752000716	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
1271752000717	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1271752000718	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1271752000719	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1271752000720	G1 box; other site
1271752000721	GTP/Mg2+ binding site [chemical binding]; other site
1271752000722	Switch I region; other site
1271752000723	G2 box; other site
1271752000724	G3 box; other site
1271752000725	Switch II region; other site
1271752000726	G4 box; other site
1271752000727	G5 box; other site
1271752000728	Nucleoside recognition; Region: Gate; pfam07670
1271752000729	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1271752000730	Nucleoside recognition; Region: Gate; pfam07670
1271752000731	FeoA domain; Region: FeoA; pfam04023
1271752000732	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1271752000733	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1271752000734	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1271752000735	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1271752000736	HflX GTPase family; Region: HflX; cd01878
1271752000737	G1 box; other site
1271752000738	GTP/Mg2+ binding site [chemical binding]; other site
1271752000739	Switch I region; other site
1271752000740	G2 box; other site
1271752000741	G3 box; other site
1271752000742	Switch II region; other site
1271752000743	G4 box; other site
1271752000744	G5 box; other site
1271752000745	NUMOD4 motif; Region: NUMOD4; pfam07463
1271752000746	HNH endonuclease; Region: HNH_3; pfam13392
1271752000747	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1271752000748	Surface antigen; Region: Bac_surface_Ag; pfam01103
1271752000749	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1271752000750	dimer interface [polypeptide binding]; other site
1271752000751	FMN binding site [chemical binding]; other site
1271752000752	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1271752000753	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752000754	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752000755	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1271752000756	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1271752000757	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752000758	Heavy-metal-associated domain; Region: HMA; pfam00403
1271752000759	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1271752000760	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752000761	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1271752000762	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1271752000763	active site
1271752000764	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1271752000765	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1271752000766	FAD binding pocket [chemical binding]; other site
1271752000767	conserved FAD binding motif [chemical binding]; other site
1271752000768	phosphate binding motif [ion binding]; other site
1271752000769	beta-alpha-beta structure motif; other site
1271752000770	NAD binding pocket [chemical binding]; other site
1271752000771	A new structural DNA glycosylase; Region: AlkD_like; cl11434
1271752000772	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
1271752000773	Rhomboid family; Region: Rhomboid; cl11446
1271752000774	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
1271752000775	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
1271752000776	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
1271752000777	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1271752000778	NlpC/P60 family; Region: NLPC_P60; pfam00877
1271752000779	Tic20-like protein; Region: Tic20; pfam09685
1271752000780	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1271752000781	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1271752000782	active site
1271752000783	phosphorylation site [posttranslational modification]
1271752000784	intermolecular recognition site; other site
1271752000785	dimerization interface [polypeptide binding]; other site
1271752000786	LytTr DNA-binding domain; Region: LytTR; smart00850
1271752000787	Histidine kinase; Region: His_kinase; pfam06580
1271752000788	hypothetical protein; Reviewed; Region: PRK12497
1271752000789	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1271752000790	dimer interface [polypeptide binding]; other site
1271752000791	catalytic triad [active]
1271752000792	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1271752000793	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1271752000794	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1271752000795	active site
1271752000796	HIGH motif; other site
1271752000797	dimer interface [polypeptide binding]; other site
1271752000798	KMSKS motif; other site
1271752000799	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1271752000800	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1271752000801	motif II; other site
1271752000802	RNA polymerase sigma factor; Provisional; Region: PRK12513
1271752000803	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1271752000804	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1271752000805	DNA binding residues [nucleotide binding]
1271752000806	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752000807	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1271752000808	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1271752000809	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752000810	Walker A motif; other site
1271752000811	ATP binding site [chemical binding]; other site
1271752000812	Walker B motif; other site
1271752000813	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1271752000814	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
1271752000815	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1271752000816	Substrate binding site; other site
1271752000817	SprT homologues; Region: SprT; cl01182
1271752000818	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1271752000819	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1271752000820	5S rRNA interface [nucleotide binding]; other site
1271752000821	CTC domain interface [polypeptide binding]; other site
1271752000822	L16 interface [polypeptide binding]; other site
1271752000823	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1271752000824	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1271752000825	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1271752000826	active site
1271752000827	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1271752000828	catalytic triad [active]
1271752000829	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
1271752000830	DinB superfamily; Region: DinB_2; pfam12867
1271752000831	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1271752000832	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
1271752000833	ligand binding site [chemical binding]; other site
1271752000834	excinuclease ABC subunit B; Provisional; Region: PRK05298
1271752000835	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1271752000836	ATP binding site [chemical binding]; other site
1271752000837	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1271752000838	nucleotide binding region [chemical binding]; other site
1271752000839	ATP-binding site [chemical binding]; other site
1271752000840	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1271752000841	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
1271752000842	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1271752000843	C-N hydrolase family amidase; Provisional; Region: PRK10438
1271752000844	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
1271752000845	putative active site [active]
1271752000846	catalytic triad [active]
1271752000847	dimer interface [polypeptide binding]; other site
1271752000848	multimer interface [polypeptide binding]; other site
1271752000849	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1271752000850	RIP metalloprotease RseP; Region: TIGR00054
1271752000851	active site
1271752000852	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1271752000853	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1271752000854	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1271752000855	putative substrate binding region [chemical binding]; other site
1271752000856	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1271752000857	active site
1271752000858	DNA binding site [nucleotide binding]
1271752000859	Int/Topo IB signature motif; other site
1271752000860	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1271752000861	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1271752000862	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
1271752000863	Predicted helicase [General function prediction only]; Region: COG4889
1271752000864	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1271752000865	non-specific DNA binding site [nucleotide binding]; other site
1271752000866	salt bridge; other site
1271752000867	sequence-specific DNA binding site [nucleotide binding]; other site
1271752000868	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
1271752000869	FtsH Extracellular; Region: FtsH_ext; pfam06480
1271752000870	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1271752000871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752000872	Walker A motif; other site
1271752000873	ATP binding site [chemical binding]; other site
1271752000874	Walker B motif; other site
1271752000875	arginine finger; other site
1271752000876	Peptidase family M41; Region: Peptidase_M41; pfam01434
1271752000877	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1271752000878	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1271752000879	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1271752000880	Predicted permeases [General function prediction only]; Region: COG0795
1271752000881	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1271752000882	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1271752000883	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1271752000884	Domain of unknown function (DUF4296); Region: DUF4296; pfam14129
1271752000885	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1271752000886	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
1271752000887	Ligand binding site; other site
1271752000888	Putative Catalytic site; other site
1271752000889	DXD motif; other site
1271752000890	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1271752000891	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1271752000892	MutS domain I; Region: MutS_I; pfam01624
1271752000893	MutS domain II; Region: MutS_II; pfam05188
1271752000894	MutS domain III; Region: MutS_III; pfam05192
1271752000895	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1271752000896	Walker A/P-loop; other site
1271752000897	ATP binding site [chemical binding]; other site
1271752000898	Q-loop/lid; other site
1271752000899	ABC transporter signature motif; other site
1271752000900	Walker B; other site
1271752000901	D-loop; other site
1271752000902	H-loop/switch region; other site
1271752000903	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1271752000904	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1271752000905	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1271752000906	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1271752000907	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
1271752000908	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1271752000909	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1271752000910	Mg++ binding site [ion binding]; other site
1271752000911	putative catalytic motif [active]
1271752000912	substrate binding site [chemical binding]; other site
1271752000913	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1271752000914	active site
1271752000915	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1271752000916	putative active site [active]
1271752000917	putative metal binding site [ion binding]; other site
1271752000918	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1271752000919	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1271752000920	active site
1271752000921	interdomain interaction site; other site
1271752000922	putative metal-binding site [ion binding]; other site
1271752000923	nucleotide binding site [chemical binding]; other site
1271752000924	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1271752000925	domain I; other site
1271752000926	DNA binding groove [nucleotide binding]
1271752000927	phosphate binding site [ion binding]; other site
1271752000928	domain II; other site
1271752000929	domain III; other site
1271752000930	nucleotide binding site [chemical binding]; other site
1271752000931	catalytic site [active]
1271752000932	domain IV; other site
1271752000933	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1271752000934	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
1271752000935	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1271752000936	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1271752000937	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1271752000938	ribosomal protein L33; Region: rpl33; CHL00104
1271752000939	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1271752000940	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1271752000941	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1271752000942	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1271752000943	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1271752000944	active site
1271752000945	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1271752000946	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1271752000947	Predicted metalloprotease [General function prediction only]; Region: COG2321
1271752000948	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1271752000949	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1271752000950	homopentamer interface [polypeptide binding]; other site
1271752000951	active site
1271752000952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
1271752000953	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1271752000954	active site
1271752000955	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1271752000956	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1271752000957	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1271752000958	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
1271752000959	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
1271752000960	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
1271752000961	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1271752000962	molybdopterin cofactor binding site; other site
1271752000963	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
1271752000964	4Fe-4S binding domain; Region: Fer4; cl02805
1271752000965	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
1271752000966	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1271752000967	Cytochrome c; Region: Cytochrom_C; pfam00034
1271752000968	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
1271752000969	heme-binding residues [chemical binding]; other site
1271752000970	Sporulation related domain; Region: SPOR; cl10051
1271752000971	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1271752000972	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1271752000973	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752000974	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1271752000975	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1271752000976	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1271752000977	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1271752000978	DNA binding residues [nucleotide binding]
1271752000979	dimerization interface [polypeptide binding]; other site
1271752000980	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
1271752000981	ATP binding site [chemical binding]; other site
1271752000982	substrate interface [chemical binding]; other site
1271752000983	Transglycosylase; Region: Transgly; pfam00912
1271752000984	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1271752000985	GldH lipoprotein; Region: GldH_lipo; pfam14109
1271752000986	PSP1 C-terminal conserved region; Region: PSP1; cl00770
1271752000987	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1271752000988	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1271752000989	active site
1271752000990	trimer interface [polypeptide binding]; other site
1271752000991	dimer interface [polypeptide binding]; other site
1271752000992	Haem-binding domain; Region: Haem_bd; pfam14376
1271752000993	Protein of unknown function, DUF393; Region: DUF393; pfam04134
1271752000994	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752000995	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1271752000996	C-terminal peptidase (prc); Region: prc; TIGR00225
1271752000997	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1271752000998	protein binding site [polypeptide binding]; other site
1271752000999	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1271752001000	Catalytic dyad [active]
1271752001001	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
1271752001002	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1271752001003	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1271752001004	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1271752001005	active site
1271752001006	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1271752001007	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1271752001008	putative active site [active]
1271752001009	Fe-S metabolism associated domain; Region: SufE; cl00951
1271752001010	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1271752001011	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1271752001012	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1271752001013	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1271752001014	Clp amino terminal domain; Region: Clp_N; pfam02861
1271752001015	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752001016	Walker A motif; other site
1271752001017	ATP binding site [chemical binding]; other site
1271752001018	Walker B motif; other site
1271752001019	arginine finger; other site
1271752001020	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752001021	Walker A motif; other site
1271752001022	ATP binding site [chemical binding]; other site
1271752001023	Walker B motif; other site
1271752001024	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1271752001025	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1271752001026	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1271752001027	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
1271752001028	ribonuclease R; Region: RNase_R; TIGR02063
1271752001029	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1271752001030	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1271752001031	RNB domain; Region: RNB; pfam00773
1271752001032	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1271752001033	RNA binding site [nucleotide binding]; other site
1271752001034	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1271752001035	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1271752001036	DNA binding residues [nucleotide binding]
1271752001037	dimerization interface [polypeptide binding]; other site
1271752001038	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
1271752001039	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1271752001040	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1271752001041	NAD(P) binding site [chemical binding]; other site
1271752001042	homotetramer interface [polypeptide binding]; other site
1271752001043	homodimer interface [polypeptide binding]; other site
1271752001044	active site
1271752001045	Predicted methyltransferases [General function prediction only]; Region: COG0313
1271752001046	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1271752001047	putative SAM binding site [chemical binding]; other site
1271752001048	putative homodimer interface [polypeptide binding]; other site
1271752001049	thymidine kinase; Provisional; Region: PRK04296
1271752001050	putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930
1271752001051	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1271752001052	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1271752001053	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1271752001054	active site
1271752001055	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1271752001056	dimer interface [polypeptide binding]; other site
1271752001057	substrate binding site [chemical binding]; other site
1271752001058	catalytic residues [active]
1271752001059	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1271752001060	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1271752001061	Walker A/P-loop; other site
1271752001062	ATP binding site [chemical binding]; other site
1271752001063	Q-loop/lid; other site
1271752001064	ABC transporter signature motif; other site
1271752001065	Walker B; other site
1271752001066	D-loop; other site
1271752001067	H-loop/switch region; other site
1271752001068	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1271752001069	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1271752001070	Outer membrane efflux protein; Region: OEP; pfam02321
1271752001071	Outer membrane efflux protein; Region: OEP; pfam02321
1271752001072	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1271752001073	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
1271752001074	FAD binding domain; Region: FAD_binding_4; pfam01565
1271752001075	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1271752001076	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1271752001077	Uncharacterized conserved protein [Function unknown]; Region: COG3743
1271752001078	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1271752001079	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
1271752001080	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1271752001081	putative catalytic residue [active]
1271752001082	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1271752001083	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1271752001084	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1271752001085	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1271752001086	hinge; other site
1271752001087	active site
1271752001088	Domain of unknown function (DUF4290); Region: DUF4290; pfam14123
1271752001089	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1271752001090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1271752001091	active site
1271752001092	phosphorylation site [posttranslational modification]
1271752001093	intermolecular recognition site; other site
1271752001094	dimerization interface [polypeptide binding]; other site
1271752001095	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1271752001096	DNA binding site [nucleotide binding]
1271752001097	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1271752001098	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1271752001099	dimer interface [polypeptide binding]; other site
1271752001100	phosphorylation site [posttranslational modification]
1271752001101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1271752001102	ATP binding site [chemical binding]; other site
1271752001103	Mg2+ binding site [ion binding]; other site
1271752001104	G-X-G motif; other site
1271752001105	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
1271752001106	Zn binding site [ion binding]; other site
1271752001107	Type III pantothenate kinase; Region: Pan_kinase; cl17198
1271752001108	FeS assembly protein SufD; Region: sufD; TIGR01981
1271752001109	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
1271752001110	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1271752001111	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1271752001112	Walker A/P-loop; other site
1271752001113	ATP binding site [chemical binding]; other site
1271752001114	Q-loop/lid; other site
1271752001115	ABC transporter signature motif; other site
1271752001116	Walker B; other site
1271752001117	D-loop; other site
1271752001118	H-loop/switch region; other site
1271752001119	Domain of unknown function (DUF336); Region: DUF336; pfam03928
1271752001120	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1271752001121	active site
1271752001122	homotetramer interface [polypeptide binding]; other site
1271752001123	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
1271752001124	NlpE N-terminal domain; Region: NlpE; pfam04170
1271752001125	V-type ATP synthase subunit I; Validated; Region: PRK05771
1271752001126	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1271752001127	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1271752001128	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
1271752001129	putative ABC transporter; Region: ycf24; CHL00085
1271752001130	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
1271752001131	four helix bundle protein; Region: TIGR02436
1271752001132	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1271752001133	GTP-binding protein LepA; Provisional; Region: PRK05433
1271752001134	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1271752001135	G1 box; other site
1271752001136	putative GEF interaction site [polypeptide binding]; other site
1271752001137	GTP/Mg2+ binding site [chemical binding]; other site
1271752001138	Switch I region; other site
1271752001139	G2 box; other site
1271752001140	G3 box; other site
1271752001141	Switch II region; other site
1271752001142	G4 box; other site
1271752001143	G5 box; other site
1271752001144	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1271752001145	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1271752001146	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1271752001147	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1271752001148	putative active site [active]
1271752001149	lipoprotein signal peptidase; Provisional; Region: PRK14788
1271752001150	lipoprotein signal peptidase; Provisional; Region: PRK14787
1271752001151	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
1271752001152	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
1271752001153	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1271752001154	active site
1271752001155	HIGH motif; other site
1271752001156	nucleotide binding site [chemical binding]; other site
1271752001157	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1271752001158	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1271752001159	active site
1271752001160	KMSKS motif; other site
1271752001161	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1271752001162	tRNA binding surface [nucleotide binding]; other site
1271752001163	anticodon binding site; other site
1271752001164	aspartate aminotransferase; Provisional; Region: PRK07568
1271752001165	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1271752001166	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752001167	homodimer interface [polypeptide binding]; other site
1271752001168	catalytic residue [active]
1271752001169	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1271752001170	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752001171	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1271752001172	hypothetical protein; Validated; Region: PRK00029
1271752001173	hypothetical protein; Validated; Region: PRK00029
1271752001174	Fic family protein [Function unknown]; Region: COG3177
1271752001175	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
1271752001176	Fic/DOC family; Region: Fic; pfam02661
1271752001177	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752001178	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1271752001179	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
1271752001180	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1271752001181	substrate-cofactor binding pocket; other site
1271752001182	para-aminobenzoate synthase component I; Validated; Region: PRK07093
1271752001183	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1271752001184	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1271752001185	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
1271752001186	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1271752001187	binding surface
1271752001188	TPR motif; other site
1271752001189	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1271752001190	TPR motif; other site
1271752001191	TPR repeat; Region: TPR_11; pfam13414
1271752001192	binding surface
1271752001193	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1271752001194	binding surface
1271752001195	TPR motif; other site
1271752001196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1271752001197	binding surface
1271752001198	TPR motif; other site
1271752001199	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1271752001200	binding surface
1271752001201	TPR motif; other site
1271752001202	TPR repeat; Region: TPR_11; pfam13414
1271752001203	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
1271752001204	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
1271752001205	active site
1271752001206	substrate binding site [chemical binding]; other site
1271752001207	metal binding site [ion binding]; metal-binding site
1271752001208	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1271752001209	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1271752001210	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1271752001211	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1271752001212	E3 interaction surface; other site
1271752001213	lipoyl attachment site [posttranslational modification]; other site
1271752001214	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1271752001215	lipoyl-biotinyl attachment site [posttranslational modification]; other site
1271752001216	HlyD family secretion protein; Region: HlyD_3; pfam13437
1271752001217	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1271752001218	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1271752001219	active site
1271752001220	substrate-binding site [chemical binding]; other site
1271752001221	metal-binding site [ion binding]
1271752001222	ATP binding site [chemical binding]; other site
1271752001223	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
1271752001224	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1271752001225	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
1271752001226	active site
1271752001227	nucleophile elbow; other site
1271752001228	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
1271752001229	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
1271752001230	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1271752001231	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1271752001232	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1271752001233	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1271752001234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1271752001235	S-adenosylmethionine binding site [chemical binding]; other site
1271752001236	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1271752001237	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1271752001238	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1271752001239	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
1271752001240	M28 Zn-Peptidases; Region: M28_like_4; cd08015
1271752001241	Peptidase family M28; Region: Peptidase_M28; pfam04389
1271752001242	metal binding site [ion binding]; metal-binding site
1271752001243	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
1271752001244	starch binding outer membrane protein SusD; Region: SusD; cd08977
1271752001245	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
1271752001246	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1271752001247	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752001248	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1271752001249	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
1271752001250	active site
1271752001251	purine riboside binding site [chemical binding]; other site
1271752001252	Phosphoglycerate kinase; Region: PGK; pfam00162
1271752001253	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1271752001254	substrate binding site [chemical binding]; other site
1271752001255	hinge regions; other site
1271752001256	ADP binding site [chemical binding]; other site
1271752001257	catalytic site [active]
1271752001258	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
1271752001259	Peptidase S46; Region: Peptidase_S46; pfam10459
1271752001260	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1271752001261	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
1271752001262	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1271752001263	dimer interface [polypeptide binding]; other site
1271752001264	tetramer interface [polypeptide binding]; other site
1271752001265	PYR/PP interface [polypeptide binding]; other site
1271752001266	TPP binding site [chemical binding]; other site
1271752001267	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1271752001268	TPP-binding site; other site
1271752001269	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1271752001270	E-class dimer interface [polypeptide binding]; other site
1271752001271	P-class dimer interface [polypeptide binding]; other site
1271752001272	active site
1271752001273	Cu2+ binding site [ion binding]; other site
1271752001274	Zn2+ binding site [ion binding]; other site
1271752001275	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1271752001276	nucleoside/Zn binding site; other site
1271752001277	dimer interface [polypeptide binding]; other site
1271752001278	catalytic motif [active]
1271752001279	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1271752001280	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1271752001281	non-specific DNA binding site [nucleotide binding]; other site
1271752001282	salt bridge; other site
1271752001283	sequence-specific DNA binding site [nucleotide binding]; other site
1271752001284	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1271752001285	SelR domain; Region: SelR; pfam01641
1271752001286	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
1271752001287	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752001288	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
1271752001289	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1271752001290	ATP binding site [chemical binding]; other site
1271752001291	Mg2+ binding site [ion binding]; other site
1271752001292	G-X-G motif; other site
1271752001293	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1271752001294	ATP binding site [chemical binding]; other site
1271752001295	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
1271752001296	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1271752001297	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
1271752001298	putative catalytic site [active]
1271752001299	putative metal binding site [ion binding]; other site
1271752001300	putative phosphate binding site [ion binding]; other site
1271752001301	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1271752001302	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1271752001303	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1271752001304	TRAM domain; Region: TRAM; pfam01938
1271752001305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1271752001306	S-adenosylmethionine binding site [chemical binding]; other site
1271752001307	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1271752001308	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1271752001309	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1271752001310	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
1271752001311	Domain of unknown function (DUF389); Region: DUF389; pfam04087
1271752001312	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1271752001313	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1271752001314	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1271752001315	catalytic residue [active]
1271752001316	putative FPP diphosphate  binding site; other site
1271752001317	putative FPP binding hydrophobic cleft; other site
1271752001318	dimer interface [polypeptide binding]; other site
1271752001319	putative IPP diphosphate binding site; other site
1271752001320	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
1271752001321	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1271752001322	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1271752001323	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1271752001324	Surface antigen; Region: Bac_surface_Ag; pfam01103
1271752001325	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1271752001326	periplasmic chaperone; Provisional; Region: PRK10780
1271752001327	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
1271752001328	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1271752001329	active site
1271752001330	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1271752001331	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1271752001332	NADP binding site [chemical binding]; other site
1271752001333	active site
1271752001334	putative substrate binding site [chemical binding]; other site
1271752001335	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752001336	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1271752001337	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1271752001338	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1271752001339	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752001340	Walker A motif; other site
1271752001341	ATP binding site [chemical binding]; other site
1271752001342	Walker B motif; other site
1271752001343	arginine finger; other site
1271752001344	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1271752001345	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1271752001346	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1271752001347	Coenzyme A binding pocket [chemical binding]; other site
1271752001348	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1271752001349	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1271752001350	G1 box; other site
1271752001351	GTP/Mg2+ binding site [chemical binding]; other site
1271752001352	Switch I region; other site
1271752001353	G2 box; other site
1271752001354	G3 box; other site
1271752001355	Switch II region; other site
1271752001356	G4 box; other site
1271752001357	G5 box; other site
1271752001358	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1271752001359	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1271752001360	cell division protein MraZ; Reviewed; Region: PRK00326
1271752001361	MraZ protein; Region: MraZ; pfam02381
1271752001362	MraZ protein; Region: MraZ; pfam02381
1271752001363	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1271752001364	MraW methylase family; Region: Methyltransf_5; cl17771
1271752001365	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1271752001366	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1271752001367	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1271752001368	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1271752001369	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1271752001370	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1271752001371	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1271752001372	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1271752001373	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1271752001374	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1271752001375	Mg++ binding site [ion binding]; other site
1271752001376	putative catalytic motif [active]
1271752001377	putative substrate binding site [chemical binding]; other site
1271752001378	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
1271752001379	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1271752001380	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1271752001381	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1271752001382	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1271752001383	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1271752001384	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1271752001385	active site
1271752001386	homodimer interface [polypeptide binding]; other site
1271752001387	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1271752001388	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1271752001389	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1271752001390	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1271752001391	cell division protein FtsA; Region: ftsA; TIGR01174
1271752001392	Cell division protein FtsA; Region: FtsA; smart00842
1271752001393	Cell division protein FtsA; Region: FtsA; pfam14450
1271752001394	cell division protein FtsZ; Validated; Region: PRK09330
1271752001395	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1271752001396	nucleotide binding site [chemical binding]; other site
1271752001397	SulA interaction site; other site
1271752001398	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1271752001399	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1271752001400	NAD(P) binding site [chemical binding]; other site
1271752001401	catalytic residues [active]
1271752001402	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1271752001403	human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; Region: 17beta-HSDXI-like_SDR_c; cd05339
1271752001404	putative NAD(P) binding site [chemical binding]; other site
1271752001405	homodimer interface [polypeptide binding]; other site
1271752001406	active site
1271752001407	substrate binding site [chemical binding]; other site
1271752001408	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1271752001409	Surface antigen; Region: Bac_surface_Ag; pfam01103
1271752001410	Family of unknown function (DUF490); Region: DUF490; pfam04357
1271752001411	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
1271752001412	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1271752001413	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1271752001414	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1271752001415	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1271752001416	ABC transporter; Region: ABC_tran_2; pfam12848
1271752001417	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1271752001418	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1271752001419	SmpB-tmRNA interface; other site
1271752001420	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1271752001421	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1271752001422	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1271752001423	ligand binding site [chemical binding]; other site
1271752001424	hypothetical protein; Validated; Region: PRK00110
1271752001425	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1271752001426	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1271752001427	PCRF domain; Region: PCRF; pfam03462
1271752001428	RF-1 domain; Region: RF-1; pfam00472
1271752001429	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
1271752001430	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1271752001431	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1271752001432	active site
1271752001433	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1271752001434	substrate binding site [chemical binding]; other site
1271752001435	catalytic residues [active]
1271752001436	dimer interface [polypeptide binding]; other site
1271752001437	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
1271752001438	Amidinotransferase; Region: Amidinotransf; pfam02274
1271752001439	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
1271752001440	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1271752001441	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1271752001442	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1271752001443	HlyD family secretion protein; Region: HlyD_3; pfam13437
1271752001444	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1271752001445	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1271752001446	putative active site [active]
1271752001447	putative metal binding site [ion binding]; other site
1271752001448	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1271752001449	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
1271752001450	starch binding outer membrane protein SusD; Region: SusD; cd08977
1271752001451	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
1271752001452	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1271752001453	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752001454	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1271752001455	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752001456	Cna protein B-type domain; Region: Cna_B_2; pfam13715
1271752001457	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1271752001458	DHH family; Region: DHH; pfam01368
1271752001459	DHHA1 domain; Region: DHHA1; pfam02272
1271752001460	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
1271752001461	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1271752001462	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
1271752001463	Walker A/P-loop; other site
1271752001464	ATP binding site [chemical binding]; other site
1271752001465	Q-loop/lid; other site
1271752001466	ABC transporter signature motif; other site
1271752001467	Walker B; other site
1271752001468	D-loop; other site
1271752001469	H-loop/switch region; other site
1271752001470	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1271752001471	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1271752001472	S-adenosylmethionine binding site [chemical binding]; other site
1271752001473	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1271752001474	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1271752001475	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1271752001476	dimer interface [polypeptide binding]; other site
1271752001477	phosphorylation site [posttranslational modification]
1271752001478	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1271752001479	ATP binding site [chemical binding]; other site
1271752001480	Mg2+ binding site [ion binding]; other site
1271752001481	G-X-G motif; other site
1271752001482	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1271752001483	Lumazine binding domain; Region: Lum_binding; pfam00677
1271752001484	Lumazine binding domain; Region: Lum_binding; pfam00677
1271752001485	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1271752001486	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
1271752001487	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
1271752001488	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1271752001489	acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531
1271752001490	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1271752001491	carboxyltransferase (CT) interaction site; other site
1271752001492	biotinylation site [posttranslational modification]; other site
1271752001493	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1271752001494	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1271752001495	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1271752001496	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1271752001497	ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885
1271752001498	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1271752001499	inhibitor-cofactor binding pocket; inhibition site
1271752001500	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752001501	catalytic residue [active]
1271752001502	The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693
1271752001503	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1271752001504	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1271752001505	Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672
1271752001506	Cupin domain; Region: Cupin_2; cl17218
1271752001507	SurA N-terminal domain; Region: SurA_N_3; cl07813
1271752001508	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1271752001509	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
1271752001510	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1271752001511	mce related protein; Region: MCE; pfam02470
1271752001512	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
1271752001513	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1271752001514	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
1271752001515	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1271752001516	Cysteine-rich domain; Region: CCG; pfam02754
1271752001517	Cysteine-rich domain; Region: CCG; pfam02754
1271752001518	7-cyano-7-deazaguanine reductase; Region: QueF; TIGR03138
1271752001519	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1271752001520	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1271752001521	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1271752001522	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1271752001523	acyl carrier protein; Provisional; Region: acpP; PRK00982
1271752001524	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1271752001525	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1271752001526	dimer interface [polypeptide binding]; other site
1271752001527	active site
1271752001528	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
1271752001529	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1271752001530	dimerization interface [polypeptide binding]; other site
1271752001531	active site
1271752001532	metal binding site [ion binding]; metal-binding site
1271752001533	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054
1271752001534	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
1271752001535	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1271752001536	active site
1271752001537	domain interfaces; other site
1271752001538	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1271752001539	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1271752001540	NAD(P) binding site [chemical binding]; other site
1271752001541	catalytic residues [active]
1271752001542	Serum amyloid A protein; Region: SAA; cl02506
1271752001543	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1271752001544	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
1271752001545	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1271752001546	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
1271752001547	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1271752001548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1271752001549	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
1271752001550	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1271752001551	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1271752001552	Ligand Binding Site [chemical binding]; other site
1271752001553	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1271752001554	seryl-tRNA synthetase; Provisional; Region: PRK05431
1271752001555	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1271752001556	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1271752001557	dimer interface [polypeptide binding]; other site
1271752001558	active site
1271752001559	motif 1; other site
1271752001560	motif 2; other site
1271752001561	motif 3; other site
1271752001562	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1271752001563	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1271752001564	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
1271752001565	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1271752001566	Peptidase family U32; Region: Peptidase_U32; pfam01136
1271752001567	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1271752001568	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1271752001569	protein binding site [polypeptide binding]; other site
1271752001570	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1271752001571	protein binding site [polypeptide binding]; other site
1271752001572	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1271752001573	active site
1271752001574	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1271752001575	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1271752001576	active site
1271752001577	HIGH motif; other site
1271752001578	nucleotide binding site [chemical binding]; other site
1271752001579	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1271752001580	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1271752001581	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1271752001582	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1271752001583	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1271752001584	active site
1271752001585	KMSKS motif; other site
1271752001586	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1271752001587	tRNA binding surface [nucleotide binding]; other site
1271752001588	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
1271752001589	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1271752001590	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
1271752001591	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1271752001592	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1271752001593	PBP superfamily domain; Region: PBP_like_2; pfam12849
1271752001594	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1271752001595	TPR motif; other site
1271752001596	binding surface
1271752001597	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1271752001598	binding surface
1271752001599	TPR motif; other site
1271752001600	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
1271752001601	Protein of unknown function (DUF3276); Region: DUF3276; pfam11680
1271752001602	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1271752001603	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1271752001604	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1271752001605	Walker A/P-loop; other site
1271752001606	ATP binding site [chemical binding]; other site
1271752001607	Q-loop/lid; other site
1271752001608	ABC transporter signature motif; other site
1271752001609	Walker B; other site
1271752001610	D-loop; other site
1271752001611	H-loop/switch region; other site
1271752001612	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
1271752001613	active site
1271752001614	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1271752001615	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752001616	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
1271752001617	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
1271752001618	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
1271752001619	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
1271752001620	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
1271752001621	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1271752001622	flavoprotein, HI0933 family; Region: TIGR00275
1271752001623	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1271752001624	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1271752001625	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1271752001626	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1271752001627	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1271752001628	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
1271752001629	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
1271752001630	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
1271752001631	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1271752001632	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
1271752001633	active site
1271752001634	intersubunit interface [polypeptide binding]; other site
1271752001635	zinc binding site [ion binding]; other site
1271752001636	Na+ binding site [ion binding]; other site
1271752001637	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1271752001638	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1271752001639	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1271752001640	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1271752001641	intersubunit interface [polypeptide binding]; other site
1271752001642	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1271752001643	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1271752001644	ABC-ATPase subunit  interface; other site
1271752001645	dimer interface [polypeptide binding]; other site
1271752001646	putative PBP binding regions; other site
1271752001647	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1271752001648	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1271752001649	Walker A/P-loop; other site
1271752001650	ATP binding site [chemical binding]; other site
1271752001651	Q-loop/lid; other site
1271752001652	ABC transporter signature motif; other site
1271752001653	Walker B; other site
1271752001654	D-loop; other site
1271752001655	H-loop/switch region; other site
1271752001656	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1271752001657	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1271752001658	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1271752001659	N-terminal plug; other site
1271752001660	ligand-binding site [chemical binding]; other site
1271752001661	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1271752001662	alpha-gamma subunit interface [polypeptide binding]; other site
1271752001663	beta-gamma subunit interface [polypeptide binding]; other site
1271752001664	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1271752001665	gamma-beta subunit interface [polypeptide binding]; other site
1271752001666	alpha-beta subunit interface [polypeptide binding]; other site
1271752001667	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1271752001668	subunit interactions [polypeptide binding]; other site
1271752001669	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1271752001670	active site
1271752001671	flap region; other site
1271752001672	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1271752001673	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1271752001674	dimer interface [polypeptide binding]; other site
1271752001675	catalytic residues [active]
1271752001676	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1271752001677	UreF; Region: UreF; pfam01730
1271752001678	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1271752001679	G1 box; other site
1271752001680	GTP/Mg2+ binding site [chemical binding]; other site
1271752001681	G2 box; other site
1271752001682	Switch I region; other site
1271752001683	G3 box; other site
1271752001684	Switch II region; other site
1271752001685	G4 box; other site
1271752001686	G5 box; other site
1271752001687	UreD urease accessory protein; Region: UreD; pfam01774
1271752001688	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
1271752001689	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
1271752001690	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1271752001691	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1271752001692	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
1271752001693	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1271752001694	Glycoprotease family; Region: Peptidase_M22; pfam00814
1271752001695	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
1271752001696	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1271752001697	Maf-like protein; Region: Maf; pfam02545
1271752001698	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1271752001699	active site
1271752001700	dimer interface [polypeptide binding]; other site
1271752001701	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1271752001702	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1271752001703	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1271752001704	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1271752001705	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1271752001706	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1271752001707	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1271752001708	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1271752001709	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1271752001710	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1271752001711	putative translocon binding site; other site
1271752001712	protein-rRNA interface [nucleotide binding]; other site
1271752001713	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1271752001714	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1271752001715	G-X-X-G motif; other site
1271752001716	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1271752001717	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1271752001718	23S rRNA interface [nucleotide binding]; other site
1271752001719	5S rRNA interface [nucleotide binding]; other site
1271752001720	putative antibiotic binding site [chemical binding]; other site
1271752001721	L25 interface [polypeptide binding]; other site
1271752001722	L27 interface [polypeptide binding]; other site
1271752001723	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1271752001724	23S rRNA interface [nucleotide binding]; other site
1271752001725	putative translocon interaction site; other site
1271752001726	signal recognition particle (SRP54) interaction site; other site
1271752001727	L23 interface [polypeptide binding]; other site
1271752001728	trigger factor interaction site; other site
1271752001729	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1271752001730	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1271752001731	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1271752001732	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1271752001733	RNA binding site [nucleotide binding]; other site
1271752001734	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1271752001735	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1271752001736	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1271752001737	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1271752001738	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1271752001739	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1271752001740	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1271752001741	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1271752001742	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1271752001743	5S rRNA interface [nucleotide binding]; other site
1271752001744	L27 interface [polypeptide binding]; other site
1271752001745	23S rRNA interface [nucleotide binding]; other site
1271752001746	L5 interface [polypeptide binding]; other site
1271752001747	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1271752001748	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1271752001749	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1271752001750	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1271752001751	23S rRNA binding site [nucleotide binding]; other site
1271752001752	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1271752001753	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1271752001754	SecY translocase; Region: SecY; pfam00344
1271752001755	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1271752001756	rRNA binding site [nucleotide binding]; other site
1271752001757	predicted 30S ribosome binding site; other site
1271752001758	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
1271752001759	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1271752001760	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1271752001761	30S ribosomal protein S11; Validated; Region: PRK05309
1271752001762	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1271752001763	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1271752001764	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1271752001765	RNA binding surface [nucleotide binding]; other site
1271752001766	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1271752001767	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1271752001768	alphaNTD - beta interaction site [polypeptide binding]; other site
1271752001769	alphaNTD homodimer interface [polypeptide binding]; other site
1271752001770	alphaNTD - beta' interaction site [polypeptide binding]; other site
1271752001771	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1271752001772	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1271752001773	Amidinotransferase; Region: Amidinotransf; cl12043
1271752001774	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
1271752001775	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1271752001776	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1271752001777	catalytic residues [active]
1271752001778	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1271752001779	dimer interface [polypeptide binding]; other site
1271752001780	Citrate synthase; Region: Citrate_synt; pfam00285
1271752001781	active site
1271752001782	citrylCoA binding site [chemical binding]; other site
1271752001783	NADH binding [chemical binding]; other site
1271752001784	cationic pore residues; other site
1271752001785	oxalacetate/citrate binding site [chemical binding]; other site
1271752001786	coenzyme A binding site [chemical binding]; other site
1271752001787	catalytic triad [active]
1271752001788	enolase; Provisional; Region: eno; PRK00077
1271752001789	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1271752001790	dimer interface [polypeptide binding]; other site
1271752001791	metal binding site [ion binding]; metal-binding site
1271752001792	substrate binding pocket [chemical binding]; other site
1271752001793	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1271752001794	homotrimer interaction site [polypeptide binding]; other site
1271752001795	putative active site [active]
1271752001796	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1271752001797	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1271752001798	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1271752001799	active site
1271752001800	metal binding site [ion binding]; metal-binding site
1271752001801	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1271752001802	Domain of unknown function (DUF3817); Region: DUF3817; cl14844
1271752001803	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1271752001804	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1271752001805	active site
1271752001806	(T/H)XGH motif; other site
1271752001807	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1271752001808	DHH family; Region: DHH; pfam01368
1271752001809	DHHA1 domain; Region: DHHA1; pfam02272
1271752001810	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
1271752001811	short chain dehydrogenase; Provisional; Region: PRK07677
1271752001812	NAD(P) binding site [chemical binding]; other site
1271752001813	substrate binding site [chemical binding]; other site
1271752001814	homotetramer interface [polypeptide binding]; other site
1271752001815	active site
1271752001816	homodimer interface [polypeptide binding]; other site
1271752001817	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1271752001818	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1271752001819	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1271752001820	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1271752001821	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1271752001822	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1271752001823	dihydroorotase; Reviewed; Region: PRK09236
1271752001824	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1271752001825	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
1271752001826	active site
1271752001827	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1271752001828	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1271752001829	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1271752001830	putative ADP-binding pocket [chemical binding]; other site
1271752001831	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1271752001832	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1271752001833	active site
1271752001834	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
1271752001835	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1271752001836	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1271752001837	putative ADP-binding pocket [chemical binding]; other site
1271752001838	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1271752001839	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1271752001840	trimer interface [polypeptide binding]; other site
1271752001841	active site
1271752001842	substrate binding site [chemical binding]; other site
1271752001843	CoA binding site [chemical binding]; other site
1271752001844	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1271752001845	active site clefts [active]
1271752001846	zinc binding site [ion binding]; other site
1271752001847	dimer interface [polypeptide binding]; other site
1271752001848	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1271752001849	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1271752001850	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1271752001851	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1271752001852	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752001853	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1271752001854	active site
1271752001855	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1271752001856	putative active site [active]
1271752001857	catalytic residue [active]
1271752001858	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1271752001859	Clp amino terminal domain; Region: Clp_N; pfam02861
1271752001860	Clp amino terminal domain; Region: Clp_N; pfam02861
1271752001861	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752001862	Walker A motif; other site
1271752001863	ATP binding site [chemical binding]; other site
1271752001864	Walker B motif; other site
1271752001865	arginine finger; other site
1271752001866	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752001867	Walker A motif; other site
1271752001868	ATP binding site [chemical binding]; other site
1271752001869	Walker B motif; other site
1271752001870	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1271752001871	GH3 auxin-responsive promoter; Region: GH3; pfam03321
1271752001872	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1271752001873	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1271752001874	HIGH motif; other site
1271752001875	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1271752001876	active site
1271752001877	KMSKS motif; other site
1271752001878	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1271752001879	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1271752001880	elongation factor Ts; Provisional; Region: tsf; PRK09377
1271752001881	UBA/TS-N domain; Region: UBA; pfam00627
1271752001882	Elongation factor TS; Region: EF_TS; pfam00889
1271752001883	Elongation factor TS; Region: EF_TS; pfam00889
1271752001884	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1271752001885	endonuclease III; Region: ENDO3c; smart00478
1271752001886	minor groove reading motif; other site
1271752001887	helix-hairpin-helix signature motif; other site
1271752001888	substrate binding pocket [chemical binding]; other site
1271752001889	active site
1271752001890	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1271752001891	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1271752001892	catalytic triad [active]
1271752001893	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1271752001894	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1271752001895	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
1271752001896	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1271752001897	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1271752001898	putative active site [active]
1271752001899	putative metal binding site [ion binding]; other site
1271752001900	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1271752001901	active site
1271752001902	cell surface protein SprA; Region: surface_SprA; TIGR04189
1271752001903	Motility related/secretion protein; Region: SprA_N; pfam14349
1271752001904	Motility related/secretion protein; Region: SprA_N; pfam14349
1271752001905	Motility related/secretion protein; Region: SprA_N; pfam14349
1271752001906	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1271752001907	RuvA N terminal domain; Region: RuvA_N; pfam01330
1271752001908	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1271752001909	starch binding outer membrane protein SusD; Region: SusD; cd08977
1271752001910	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
1271752001911	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1271752001912	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1271752001913	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1271752001914	putative DNA binding site [nucleotide binding]; other site
1271752001915	putative Zn2+ binding site [ion binding]; other site
1271752001916	AsnC family; Region: AsnC_trans_reg; pfam01037
1271752001917	Cna protein B-type domain; Region: Cna_B_2; pfam13715
1271752001918	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1271752001919	active site
1271752001920	putative DNA-binding cleft [nucleotide binding]; other site
1271752001921	dimer interface [polypeptide binding]; other site
1271752001922	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
1271752001923	heme-binding site [chemical binding]; other site
1271752001924	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1271752001925	DNA protecting protein DprA; Region: dprA; TIGR00732
1271752001926	glutamate dehydrogenase; Provisional; Region: PRK09414
1271752001927	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1271752001928	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1271752001929	NAD(P) binding site [chemical binding]; other site
1271752001930	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1271752001931	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1271752001932	Zn2+ binding site [ion binding]; other site
1271752001933	Mg2+ binding site [ion binding]; other site
1271752001934	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1271752001935	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1271752001936	active site
1271752001937	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1271752001938	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1271752001939	dimer interface [polypeptide binding]; other site
1271752001940	putative radical transfer pathway; other site
1271752001941	diiron center [ion binding]; other site
1271752001942	tyrosyl radical; other site
1271752001943	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
1271752001944	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1271752001945	active site
1271752001946	dimer interface [polypeptide binding]; other site
1271752001947	catalytic residues [active]
1271752001948	effector binding site; other site
1271752001949	R2 peptide binding site; other site
1271752001950	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1271752001951	Beta-lactamase; Region: Beta-lactamase; pfam00144
1271752001952	Protein of unknown function DUF72; Region: DUF72; pfam01904
1271752001953	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1271752001954	active site
1271752001955	catalytic residues [active]
1271752001956	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752001957	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1271752001958	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1271752001959	substrate binding site [chemical binding]; other site
1271752001960	oxyanion hole (OAH) forming residues; other site
1271752001961	trimer interface [polypeptide binding]; other site
1271752001962	DNA repair protein RadA; Provisional; Region: PRK11823
1271752001963	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1271752001964	Walker A motif; other site
1271752001965	ATP binding site [chemical binding]; other site
1271752001966	Walker B motif; other site
1271752001967	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1271752001968	Bacterial Ig-like domain; Region: Big_5; pfam13205
1271752001969	Haem-binding domain; Region: Haem_bd; pfam14376
1271752001970	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752001971	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
1271752001972	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1271752001973	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1271752001974	catalytic residues [active]
1271752001975	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752001976	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
1271752001977	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
1271752001978	active site
1271752001979	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1271752001980	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1271752001981	BON domain; Region: BON; cl02771
1271752001982	Bacterial SH3 domain; Region: SH3_3; pfam08239
1271752001983	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1271752001984	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1271752001985	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1271752001986	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1271752001987	Walker A motif; other site
1271752001988	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1271752001989	exosortase F-associated protein; Region: flavo_near_exo; TIGR04127
1271752001990	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
1271752001991	Deoxyhypusine synthase; Region: DS; cl00826
1271752001992	deoxyhypusine synthase; Region: dhys; TIGR00321
1271752001993	Deoxyhypusine synthase; Region: DS; cl00826
1271752001994	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
1271752001995	Protein of unknown function (DUF2480); Region: DUF2480; pfam10652
1271752001996	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
1271752001997	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1271752001998	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1271752001999	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1271752002000	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
1271752002001	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1271752002002	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
1271752002003	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1271752002004	FMN binding site [chemical binding]; other site
1271752002005	substrate binding site [chemical binding]; other site
1271752002006	putative catalytic residue [active]
1271752002007	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1271752002008	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1271752002009	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
1271752002010	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
1271752002011	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
1271752002012	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
1271752002013	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1271752002014	putative catalytic site [active]
1271752002015	putative metal binding site [ion binding]; other site
1271752002016	putative phosphate binding site [ion binding]; other site
1271752002017	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1271752002018	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1271752002019	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1271752002020	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1271752002021	Competence protein; Region: Competence; pfam03772
1271752002022	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
1271752002023	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
1271752002024	putative Iron-sulfur protein interface [polypeptide binding]; other site
1271752002025	proximal heme binding site [chemical binding]; other site
1271752002026	distal heme binding site [chemical binding]; other site
1271752002027	putative dimer interface [polypeptide binding]; other site
1271752002028	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
1271752002029	L-aspartate oxidase; Provisional; Region: PRK06175
1271752002030	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1271752002031	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
1271752002032	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1271752002033	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1271752002034	active site
1271752002035	DNA polymerase IV; Validated; Region: PRK02406
1271752002036	DNA binding site [nucleotide binding]
1271752002037	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1271752002038	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
1271752002039	hexamer interface [polypeptide binding]; other site
1271752002040	Walker A motif; other site
1271752002041	ATP binding site [chemical binding]; other site
1271752002042	Walker B motif; other site
1271752002043	CTP synthetase; Validated; Region: pyrG; PRK05380
1271752002044	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1271752002045	Catalytic site [active]
1271752002046	active site
1271752002047	UTP binding site [chemical binding]; other site
1271752002048	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1271752002049	active site
1271752002050	putative oxyanion hole; other site
1271752002051	catalytic triad [active]
1271752002052	membrane protein insertase; Provisional; Region: PRK01318
1271752002053	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
1271752002054	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1271752002055	RNA/DNA hybrid binding site [nucleotide binding]; other site
1271752002056	active site
1271752002057	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
1271752002058	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1271752002059	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752002060	starch binding outer membrane protein SusD; Region: SusD; cl17845
1271752002061	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
1271752002062	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1271752002063	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1271752002064	active site
1271752002065	HIGH motif; other site
1271752002066	KMSK motif region; other site
1271752002067	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1271752002068	tRNA binding surface [nucleotide binding]; other site
1271752002069	anticodon binding site; other site
1271752002070	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1271752002071	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
1271752002072	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1271752002073	FeS/SAM binding site; other site
1271752002074	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
1271752002075	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
1271752002076	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1271752002077	putative trimer interface [polypeptide binding]; other site
1271752002078	putative CoA binding site [chemical binding]; other site
1271752002079	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1271752002080	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
1271752002081	homodimer interface [polypeptide binding]; other site
1271752002082	metal binding site [ion binding]; metal-binding site
1271752002083	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1271752002084	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1271752002085	hinge; other site
1271752002086	active site
1271752002087	short chain dehydrogenase; Provisional; Region: PRK06179
1271752002088	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1271752002089	NADP binding site [chemical binding]; other site
1271752002090	active site
1271752002091	steroid binding site; other site
1271752002092	chaperone protein HchA; Provisional; Region: PRK04155
1271752002093	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1271752002094	conserved cys residue [active]
1271752002095	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1271752002096	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1271752002097	ligand binding site [chemical binding]; other site
1271752002098	flexible hinge region; other site
1271752002099	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1271752002100	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
1271752002101	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1271752002102	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1271752002103	homodimer interface [polypeptide binding]; other site
1271752002104	NADP binding site [chemical binding]; other site
1271752002105	substrate binding site [chemical binding]; other site
1271752002106	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1271752002107	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1271752002108	active site
1271752002109	dimer interface [polypeptide binding]; other site
1271752002110	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1271752002111	dimer interface [polypeptide binding]; other site
1271752002112	active site
1271752002113	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1271752002114	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1271752002115	dimer interface [polypeptide binding]; other site
1271752002116	active site
1271752002117	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1271752002118	folate binding site [chemical binding]; other site
1271752002119	RecX family; Region: RecX; pfam02631
1271752002120	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1271752002121	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
1271752002122	NAD(P) binding site [chemical binding]; other site
1271752002123	homodimer interface [polypeptide binding]; other site
1271752002124	substrate binding site [chemical binding]; other site
1271752002125	active site
1271752002126	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1271752002127	SLBB domain; Region: SLBB; pfam10531
1271752002128	tyrosine kinase; Provisional; Region: PRK11519
1271752002129	Chain length determinant protein; Region: Wzz; pfam02706
1271752002130	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1271752002131	Chain length determinant protein; Region: Wzz; cl15801
1271752002132	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1271752002133	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
1271752002134	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
1271752002135	NAD binding site [chemical binding]; other site
1271752002136	substrate binding site [chemical binding]; other site
1271752002137	homodimer interface [polypeptide binding]; other site
1271752002138	active site
1271752002139	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
1271752002140	four helix bundle protein; Region: TIGR02436
1271752002141	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
1271752002142	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1271752002143	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1271752002144	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1271752002145	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1271752002146	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1271752002147	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
1271752002148	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1271752002149	active site
1271752002150	dimer interface [polypeptide binding]; other site
1271752002151	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1271752002152	Ligand Binding Site [chemical binding]; other site
1271752002153	Molecular Tunnel; other site
1271752002154	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1271752002155	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1271752002156	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1271752002157	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1271752002158	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
1271752002159	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1271752002160	active site
1271752002161	dimer interface [polypeptide binding]; other site
1271752002162	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1271752002163	Ligand Binding Site [chemical binding]; other site
1271752002164	Molecular Tunnel; other site
1271752002165	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1271752002166	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1271752002167	putative ADP-binding pocket [chemical binding]; other site
1271752002168	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1271752002169	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1271752002170	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1271752002171	putative trimer interface [polypeptide binding]; other site
1271752002172	putative CoA binding site [chemical binding]; other site
1271752002173	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
1271752002174	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1271752002175	inhibitor-cofactor binding pocket; inhibition site
1271752002176	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752002177	catalytic residue [active]
1271752002178	Bacterial sugar transferase; Region: Bac_transf; cl00939
1271752002179	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1271752002180	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1271752002181	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1271752002182	NAD binding site [chemical binding]; other site
1271752002183	substrate binding site [chemical binding]; other site
1271752002184	homodimer interface [polypeptide binding]; other site
1271752002185	active site
1271752002186	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1271752002187	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1271752002188	substrate binding site; other site
1271752002189	tetramer interface; other site
1271752002190	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
1271752002191	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1271752002192	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1271752002193	FeS/SAM binding site; other site
1271752002194	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1271752002195	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1271752002196	folate binding site [chemical binding]; other site
1271752002197	NADP+ binding site [chemical binding]; other site
1271752002198	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1271752002199	Repair protein; Region: Repair_PSII; cl01535
1271752002200	Repair protein; Region: Repair_PSII; pfam04536
1271752002201	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
1271752002202	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1271752002203	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1271752002204	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1271752002205	TIGR01777 family protein; Region: yfcH
1271752002206	NAD(P) binding site [chemical binding]; other site
1271752002207	active site
1271752002208	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1271752002209	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1271752002210	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
1271752002211	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1271752002212	Coenzyme A binding pocket [chemical binding]; other site
1271752002213	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
1271752002214	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
1271752002215	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
1271752002216	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1271752002217	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
1271752002218	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
1271752002219	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1271752002220	putative dimer interface [polypeptide binding]; other site
1271752002221	[2Fe-2S] cluster binding site [ion binding]; other site
1271752002222	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1271752002223	SLBB domain; Region: SLBB; pfam10531
1271752002224	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1271752002225	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1271752002226	catalytic loop [active]
1271752002227	iron binding site [ion binding]; other site
1271752002228	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1271752002229	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1271752002230	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1271752002231	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
1271752002232	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1271752002233	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
1271752002234	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1271752002235	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1271752002236	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1271752002237	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1271752002238	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1271752002239	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1271752002240	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1271752002241	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1271752002242	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1271752002243	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1271752002244	dimer interface [polypeptide binding]; other site
1271752002245	catalytic triad [active]
1271752002246	peroxidatic and resolving cysteines [active]
1271752002247	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
1271752002248	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1271752002249	NAD binding site [chemical binding]; other site
1271752002250	active site
1271752002251	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
1271752002252	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1271752002253	HSP70 interaction site [polypeptide binding]; other site
1271752002254	glycine dehydrogenase; Provisional; Region: PRK05367
1271752002255	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1271752002256	tetramer interface [polypeptide binding]; other site
1271752002257	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752002258	catalytic residue [active]
1271752002259	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1271752002260	tetramer interface [polypeptide binding]; other site
1271752002261	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752002262	catalytic residue [active]
1271752002263	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1271752002264	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1271752002265	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1271752002266	ABC transporter; Region: ABC_tran_2; pfam12848
1271752002267	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1271752002268	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
1271752002269	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
1271752002270	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
1271752002271	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1271752002272	acyl-activating enzyme (AAE) consensus motif; other site
1271752002273	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1271752002274	AMP binding site [chemical binding]; other site
1271752002275	active site
1271752002276	CoA binding site [chemical binding]; other site
1271752002277	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1271752002278	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1271752002279	S-adenosylmethionine binding site [chemical binding]; other site
1271752002280	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
1271752002281	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
1271752002282	Glutamate binding site [chemical binding]; other site
1271752002283	NAD binding site [chemical binding]; other site
1271752002284	catalytic residues [active]
1271752002285	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1271752002286	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1271752002287	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
1271752002288	active site
1271752002289	acetyl-CoA C-acetyltransferase; Region: PLN02644
1271752002290	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1271752002291	dimer interface [polypeptide binding]; other site
1271752002292	active site
1271752002293	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
1271752002294	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1271752002295	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
1271752002296	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1271752002297	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1271752002298	substrate binding site [chemical binding]; other site
1271752002299	ATP binding site [chemical binding]; other site
1271752002300	Protein of unknown function (DUF4241); Region: DUF4241; pfam14025
1271752002301	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1271752002302	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1271752002303	active site
1271752002304	HIGH motif; other site
1271752002305	nucleotide binding site [chemical binding]; other site
1271752002306	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1271752002307	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1271752002308	active site
1271752002309	KMSKS motif; other site
1271752002310	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1271752002311	tRNA binding surface [nucleotide binding]; other site
1271752002312	anticodon binding site; other site
1271752002313	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1271752002314	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
1271752002315	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
1271752002316	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1271752002317	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1271752002318	Ligand binding site; other site
1271752002319	Putative Catalytic site; other site
1271752002320	DXD motif; other site
1271752002321	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
1271752002322	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1271752002323	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1271752002324	active site
1271752002325	substrate binding site [chemical binding]; other site
1271752002326	metal binding site [ion binding]; metal-binding site
1271752002327	aspartate aminotransferase; Provisional; Region: PRK05764
1271752002328	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1271752002329	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752002330	homodimer interface [polypeptide binding]; other site
1271752002331	catalytic residue [active]
1271752002332	Bacterial SH3 domain; Region: SH3_3; cl17532
1271752002333	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1271752002334	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1271752002335	Ligand binding site; other site
1271752002336	oligomer interface; other site
1271752002337	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1271752002338	catalytic residues [active]
1271752002339	dimer interface [polypeptide binding]; other site
1271752002340	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1271752002341	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
1271752002342	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1271752002343	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1271752002344	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1271752002345	DNA binding residues [nucleotide binding]
1271752002346	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1271752002347	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1271752002348	substrate binding site [chemical binding]; other site
1271752002349	hexamer interface [polypeptide binding]; other site
1271752002350	metal binding site [ion binding]; metal-binding site
1271752002351	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
1271752002352	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
1271752002353	prolyl-tRNA synthetase; Provisional; Region: PRK08661
1271752002354	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
1271752002355	dimer interface [polypeptide binding]; other site
1271752002356	motif 1; other site
1271752002357	active site
1271752002358	motif 2; other site
1271752002359	motif 3; other site
1271752002360	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
1271752002361	anticodon binding site; other site
1271752002362	zinc-binding site [ion binding]; other site
1271752002363	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
1271752002364	manganese transport protein MntH; Reviewed; Region: PRK00701
1271752002365	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1271752002366	GrpE; Region: GrpE; pfam01025
1271752002367	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1271752002368	dimer interface [polypeptide binding]; other site
1271752002369	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1271752002370	chaperone protein DnaJ; Provisional; Region: PRK14289
1271752002371	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1271752002372	HSP70 interaction site [polypeptide binding]; other site
1271752002373	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1271752002374	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1271752002375	dimer interface [polypeptide binding]; other site
1271752002376	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1271752002377	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1271752002378	Walker A/P-loop; other site
1271752002379	ATP binding site [chemical binding]; other site
1271752002380	Q-loop/lid; other site
1271752002381	ABC transporter signature motif; other site
1271752002382	Walker B; other site
1271752002383	D-loop; other site
1271752002384	H-loop/switch region; other site
1271752002385	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1271752002386	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1271752002387	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1271752002388	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1271752002389	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1271752002390	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1271752002391	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
1271752002392	fumarylacetoacetase; Region: PLN02856
1271752002393	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
1271752002394	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1271752002395	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
1271752002396	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1271752002397	dimer interface [polypeptide binding]; other site
1271752002398	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1271752002399	active site
1271752002400	Fe binding site [ion binding]; other site
1271752002401	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
1271752002402	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
1271752002403	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1271752002404	replicative DNA helicase; Region: DnaB; TIGR00665
1271752002405	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1271752002406	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1271752002407	Walker A motif; other site
1271752002408	ATP binding site [chemical binding]; other site
1271752002409	Walker B motif; other site
1271752002410	DNA binding loops [nucleotide binding]
1271752002411	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1271752002412	RNA/DNA hybrid binding site [nucleotide binding]; other site
1271752002413	active site
1271752002414	Uncharacterized conserved protein [Function unknown]; Region: COG2968
1271752002415	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1271752002416	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1271752002417	PGAP1-like protein; Region: PGAP1; pfam07819
1271752002418	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752002419	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1271752002420	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1271752002421	active site
1271752002422	HIGH motif; other site
1271752002423	dimer interface [polypeptide binding]; other site
1271752002424	KMSKS motif; other site
1271752002425	putative hydrolase; Provisional; Region: PRK11460
1271752002426	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
1271752002427	AIR carboxylase; Region: AIRC; pfam00731
1271752002428	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1271752002429	ATP-grasp domain; Region: ATP-grasp; pfam02222
1271752002430	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1271752002431	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1271752002432	putative metal binding site [ion binding]; other site
1271752002433	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
1271752002434	diphosphomevalonate decarboxylase; Region: PLN02407
1271752002435	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1271752002436	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1271752002437	acyl-activating enzyme (AAE) consensus motif; other site
1271752002438	putative AMP binding site [chemical binding]; other site
1271752002439	putative active site [active]
1271752002440	putative CoA binding site [chemical binding]; other site
1271752002441	Peptidase family M48; Region: Peptidase_M48; pfam01435
1271752002442	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
1271752002443	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1271752002444	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1271752002445	Walker A/P-loop; other site
1271752002446	ATP binding site [chemical binding]; other site
1271752002447	Q-loop/lid; other site
1271752002448	ABC transporter signature motif; other site
1271752002449	Walker B; other site
1271752002450	D-loop; other site
1271752002451	H-loop/switch region; other site
1271752002452	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1271752002453	Permease; Region: Permease; pfam02405
1271752002454	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1271752002455	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1271752002456	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1271752002457	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1271752002458	FeS/SAM binding site; other site
1271752002459	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1271752002460	RimM N-terminal domain; Region: RimM; pfam01782
1271752002461	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1271752002462	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752002463	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
1271752002464	dimer interface [polypeptide binding]; other site
1271752002465	active site
1271752002466	aspartate-rich active site metal binding site; other site
1271752002467	allosteric magnesium binding site [ion binding]; other site
1271752002468	Schiff base residues; other site
1271752002469	glutamate racemase; Provisional; Region: PRK00865
1271752002470	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1271752002471	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1271752002472	putative active site [active]
1271752002473	substrate binding site [chemical binding]; other site
1271752002474	putative cosubstrate binding site; other site
1271752002475	catalytic site [active]
1271752002476	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1271752002477	substrate binding site [chemical binding]; other site
1271752002478	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1271752002479	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1271752002480	ATP binding site [chemical binding]; other site
1271752002481	putative Mg++ binding site [ion binding]; other site
1271752002482	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1271752002483	nucleotide binding region [chemical binding]; other site
1271752002484	ATP-binding site [chemical binding]; other site
1271752002485	malate dehydrogenase; Reviewed; Region: PRK06223
1271752002486	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
1271752002487	dimer interface [polypeptide binding]; other site
1271752002488	NAD(P) binding site [chemical binding]; other site
1271752002489	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1271752002490	substrate binding site [chemical binding]; other site
1271752002491	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
1271752002492	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1271752002493	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1271752002494	RNase E interface [polypeptide binding]; other site
1271752002495	trimer interface [polypeptide binding]; other site
1271752002496	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1271752002497	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1271752002498	RNase E interface [polypeptide binding]; other site
1271752002499	trimer interface [polypeptide binding]; other site
1271752002500	active site
1271752002501	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1271752002502	putative nucleic acid binding region [nucleotide binding]; other site
1271752002503	G-X-X-G motif; other site
1271752002504	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1271752002505	RNA binding site [nucleotide binding]; other site
1271752002506	domain interface; other site
1271752002507	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1271752002508	16S/18S rRNA binding site [nucleotide binding]; other site
1271752002509	S13e-L30e interaction site [polypeptide binding]; other site
1271752002510	25S rRNA binding site [nucleotide binding]; other site
1271752002511	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1271752002512	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1271752002513	active site
1271752002514	catalytic site [active]
1271752002515	substrate binding site [chemical binding]; other site
1271752002516	DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594
1271752002517	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1271752002518	active site
1271752002519	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1271752002520	generic binding surface II; other site
1271752002521	generic binding surface I; other site
1271752002522	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
1271752002523	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
1271752002524	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1271752002525	putative acyl-acceptor binding pocket; other site
1271752002526	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1271752002527	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1271752002528	aspartate kinase; Region: asp_kinases; TIGR00657
1271752002529	nucleotide binding site [chemical binding]; other site
1271752002530	substrate binding site [chemical binding]; other site
1271752002531	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1271752002532	metal binding site [ion binding]; metal-binding site
1271752002533	active site
1271752002534	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1271752002535	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1271752002536	active site
1271752002537	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1271752002538	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1271752002539	Zn2+ binding site [ion binding]; other site
1271752002540	Mg2+ binding site [ion binding]; other site
1271752002541	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1271752002542	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1271752002543	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1271752002544	trimer interface [polypeptide binding]; other site
1271752002545	active site
1271752002546	UDP-GlcNAc binding site [chemical binding]; other site
1271752002547	lipid binding site [chemical binding]; lipid-binding site
1271752002548	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
1271752002549	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1271752002550	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1271752002551	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1271752002552	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1271752002553	active site
1271752002554	elongation factor P; Validated; Region: PRK00529
1271752002555	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1271752002556	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1271752002557	RNA binding site [nucleotide binding]; other site
1271752002558	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1271752002559	RNA binding site [nucleotide binding]; other site
1271752002560	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1271752002561	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1271752002562	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1271752002563	trimer interface [polypeptide binding]; other site
1271752002564	active site
1271752002565	UDP-GlcNAc binding site [chemical binding]; other site
1271752002566	lipid binding site [chemical binding]; lipid-binding site
1271752002567	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1271752002568	CoA binding domain; Region: CoA_binding; smart00881
1271752002569	CoA-ligase; Region: Ligase_CoA; pfam00549
1271752002570	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
1271752002571	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
1271752002572	Peptidase family M1; Region: Peptidase_M1; pfam01433
1271752002573	Zn binding site [ion binding]; other site
1271752002574	HEAT repeats; Region: HEAT_2; pfam13646
1271752002575	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1271752002576	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1271752002577	dimerization interface [polypeptide binding]; other site
1271752002578	active site
1271752002579	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752002580	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752002581	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
1271752002582	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1271752002583	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1271752002584	FMN binding site [chemical binding]; other site
1271752002585	active site
1271752002586	catalytic residues [active]
1271752002587	substrate binding site [chemical binding]; other site
1271752002588	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
1271752002589	putative active site [active]
1271752002590	putative catalytic site [active]
1271752002591	putative DNA binding site [nucleotide binding]; other site
1271752002592	putative phosphate binding site [ion binding]; other site
1271752002593	metal binding site A [ion binding]; metal-binding site
1271752002594	putative AP binding site [nucleotide binding]; other site
1271752002595	putative metal binding site B [ion binding]; other site
1271752002596	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1271752002597	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1271752002598	trigger factor; Region: tig; TIGR00115
1271752002599	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
1271752002600	Cna protein B-type domain; Region: Cna_B_2; pfam13715
1271752002601	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1271752002602	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752002603	6-phosphofructokinase; Provisional; Region: PRK03202
1271752002604	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1271752002605	active site
1271752002606	ADP/pyrophosphate binding site [chemical binding]; other site
1271752002607	dimerization interface [polypeptide binding]; other site
1271752002608	allosteric effector site; other site
1271752002609	fructose-1,6-bisphosphate binding site; other site
1271752002610	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1271752002611	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1271752002612	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1271752002613	recA bacterial DNA recombination protein; Region: RecA; cl17211
1271752002614	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1271752002615	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1271752002616	active site
1271752002617	metal binding site [ion binding]; metal-binding site
1271752002618	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752002619	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1271752002620	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1271752002621	alpha subunit interface [polypeptide binding]; other site
1271752002622	TPP binding site [chemical binding]; other site
1271752002623	heterodimer interface [polypeptide binding]; other site
1271752002624	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1271752002625	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1271752002626	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1271752002627	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1271752002628	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1271752002629	RNA binding site [nucleotide binding]; other site
1271752002630	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
1271752002631	MutS domain III; Region: MutS_III; pfam05192
1271752002632	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1271752002633	Walker A/P-loop; other site
1271752002634	ATP binding site [chemical binding]; other site
1271752002635	Q-loop/lid; other site
1271752002636	ABC transporter signature motif; other site
1271752002637	Walker B; other site
1271752002638	D-loop; other site
1271752002639	H-loop/switch region; other site
1271752002640	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1271752002641	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1271752002642	catalytic residues [active]
1271752002643	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752002644	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1271752002645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752002646	Walker A motif; other site
1271752002647	ATP binding site [chemical binding]; other site
1271752002648	Walker B motif; other site
1271752002649	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1271752002650	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1271752002651	nucleotide binding site/active site [active]
1271752002652	HIT family signature motif; other site
1271752002653	catalytic residue [active]
1271752002654	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1271752002655	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1271752002656	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1271752002657	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1271752002658	dimerization interface [polypeptide binding]; other site
1271752002659	putative tRNAtyr binding site [nucleotide binding]; other site
1271752002660	putative active site [active]
1271752002661	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
1271752002662	tandem repeat interface [polypeptide binding]; other site
1271752002663	oligomer interface [polypeptide binding]; other site
1271752002664	active site residues [active]
1271752002665	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1271752002666	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1271752002667	tandem repeat interface [polypeptide binding]; other site
1271752002668	oligomer interface [polypeptide binding]; other site
1271752002669	active site residues [active]
1271752002670	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1271752002671	catalytic center binding site [active]
1271752002672	ATP binding site [chemical binding]; other site
1271752002673	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1271752002674	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1271752002675	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1271752002676	ligand binding site [chemical binding]; other site
1271752002677	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1271752002678	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1271752002679	ligand binding site [chemical binding]; other site
1271752002680	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1271752002681	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1271752002682	active site
1271752002683	Zn binding site [ion binding]; other site
1271752002684	Protein of unknown function (DUF456); Region: DUF456; pfam04306
1271752002685	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1271752002686	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1271752002687	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1271752002688	active site
1271752002689	hydrophilic channel; other site
1271752002690	dimerization interface [polypeptide binding]; other site
1271752002691	catalytic residues [active]
1271752002692	active site lid [active]
1271752002693	PGAP1-like protein; Region: PGAP1; pfam07819
1271752002694	acyl-CoA esterase; Provisional; Region: PRK10673
1271752002695	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1271752002696	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1271752002697	NAD(P) binding site [chemical binding]; other site
1271752002698	active site
1271752002699	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
1271752002700	Sulfatase; Region: Sulfatase; cl17466
1271752002701	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1271752002702	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
1271752002703	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1271752002704	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1271752002705	amidase catalytic site [active]
1271752002706	Zn binding residues [ion binding]; other site
1271752002707	substrate binding site [chemical binding]; other site
1271752002708	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1271752002709	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
1271752002710	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
1271752002711	polyphosphate kinase; Provisional; Region: PRK05443
1271752002712	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1271752002713	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1271752002714	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
1271752002715	domain interface [polypeptide binding]; other site
1271752002716	active site
1271752002717	catalytic site [active]
1271752002718	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1271752002719	putative active site [active]
1271752002720	catalytic site [active]
1271752002721	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1271752002722	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1271752002723	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1271752002724	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1271752002725	N-terminal plug; other site
1271752002726	ligand-binding site [chemical binding]; other site
1271752002727	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
1271752002728	Domain of unknown function (DUF1832); Region: DUF1832; cl07463
1271752002729	AAA-like domain; Region: AAA_10; pfam12846
1271752002730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752002731	Walker A motif; other site
1271752002732	ATP binding site [chemical binding]; other site
1271752002733	Walker B motif; other site
1271752002734	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
1271752002735	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1271752002736	Walker A/P-loop; other site
1271752002737	ATP binding site [chemical binding]; other site
1271752002738	putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183
1271752002739	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1271752002740	Active Sites [active]
1271752002741	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1271752002742	Ligand Binding Site [chemical binding]; other site
1271752002743	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1271752002744	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1271752002745	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1271752002746	active site
1271752002747	catalytic site [active]
1271752002748	substrate binding site [chemical binding]; other site
1271752002749	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1271752002750	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1271752002751	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1271752002752	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1271752002753	active site
1271752002754	Zn binding site [ion binding]; other site
1271752002755	competence damage-inducible protein A; Provisional; Region: PRK00549
1271752002756	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1271752002757	putative MPT binding site; other site
1271752002758	Competence-damaged protein; Region: CinA; pfam02464
1271752002759	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
1271752002760	Alkaline phosphatase homologues; Region: alkPPc; smart00098
1271752002761	active site
1271752002762	dimer interface [polypeptide binding]; other site
1271752002763	Endonuclease I; Region: Endonuclease_1; pfam04231
1271752002764	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752002765	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1271752002766	FtsX-like permease family; Region: FtsX; pfam02687
1271752002767	Ribosome-binding factor A; Region: RBFA; pfam02033
1271752002768	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1271752002769	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1271752002770	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1271752002771	DNA binding residues [nucleotide binding]
1271752002772	lipoyl synthase; Provisional; Region: PRK05481
1271752002773	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1271752002774	FeS/SAM binding site; other site
1271752002775	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1271752002776	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1271752002777	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1271752002778	catalytic residues [active]
1271752002779	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1271752002780	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1271752002781	Tetramer interface [polypeptide binding]; other site
1271752002782	active site
1271752002783	FMN-binding site [chemical binding]; other site
1271752002784	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1271752002785	putative catalytic site [active]
1271752002786	putative metal binding site [ion binding]; other site
1271752002787	putative phosphate binding site [ion binding]; other site
1271752002788	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
1271752002789	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
1271752002790	metal binding site [ion binding]; metal-binding site
1271752002791	dimer interface [polypeptide binding]; other site
1271752002792	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
1271752002793	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
1271752002794	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1271752002795	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1271752002796	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
1271752002797	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
1271752002798	IHF dimer interface [polypeptide binding]; other site
1271752002799	IHF - DNA interface [nucleotide binding]; other site
1271752002800	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1271752002801	active site
1271752002802	tetramerization interface [polypeptide binding]; other site
1271752002803	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1271752002804	cytidylate kinase; Provisional; Region: cmk; PRK00023
1271752002805	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1271752002806	CMP-binding site; other site
1271752002807	The sites determining sugar specificity; other site
1271752002808	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1271752002809	dihydropteroate synthase; Region: DHPS; TIGR01496
1271752002810	substrate binding pocket [chemical binding]; other site
1271752002811	dimer interface [polypeptide binding]; other site
1271752002812	inhibitor binding site; inhibition site
1271752002813	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1271752002814	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1271752002815	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1271752002816	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1271752002817	Walker A/P-loop; other site
1271752002818	ATP binding site [chemical binding]; other site
1271752002819	Q-loop/lid; other site
1271752002820	ABC transporter signature motif; other site
1271752002821	Walker B; other site
1271752002822	D-loop; other site
1271752002823	H-loop/switch region; other site
1271752002824	hypothetical protein; Reviewed; Region: PRK00024
1271752002825	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1271752002826	MPN+ (JAMM) motif; other site
1271752002827	Zinc-binding site [ion binding]; other site
1271752002828	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1271752002829	dimer interface [polypeptide binding]; other site
1271752002830	substrate binding site [chemical binding]; other site
1271752002831	metal binding sites [ion binding]; metal-binding site
1271752002832	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14970
1271752002833	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752002834	Walker A motif; other site
1271752002835	ATP binding site [chemical binding]; other site
1271752002836	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1271752002837	Walker B motif; other site
1271752002838	arginine finger; other site
1271752002839	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1271752002840	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
1271752002841	Chorismate mutase type II; Region: CM_2; smart00830
1271752002842	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1271752002843	Surface antigen; Region: Bac_surface_Ag; pfam01103
1271752002844	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1271752002845	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1271752002846	The C-terminal domain of uncharacterized bacterial proteins; Region: Bvu_2165_C_like; cd12843
1271752002847	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1271752002848	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1271752002849	THF binding site; other site
1271752002850	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1271752002851	substrate binding site [chemical binding]; other site
1271752002852	THF binding site; other site
1271752002853	zinc-binding site [ion binding]; other site
1271752002854	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1271752002855	Phosphate transporter family; Region: PHO4; pfam01384
1271752002856	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1271752002857	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
1271752002858	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1271752002859	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1271752002860	Penicillinase repressor; Region: Pencillinase_R; cl17580
1271752002861	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1271752002862	nudix motif; other site
1271752002863	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1271752002864	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1271752002865	substrate binding pocket [chemical binding]; other site
1271752002866	chain length determination region; other site
1271752002867	substrate-Mg2+ binding site; other site
1271752002868	catalytic residues [active]
1271752002869	aspartate-rich region 1; other site
1271752002870	active site lid residues [active]
1271752002871	aspartate-rich region 2; other site
1271752002872	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
1271752002873	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1271752002874	Zn binding site [ion binding]; other site
1271752002875	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1271752002876	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1271752002877	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1271752002878	catalytic residue [active]
1271752002879	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1271752002880	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1271752002881	PhnA protein; Region: PhnA; pfam03831
1271752002882	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1271752002883	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1271752002884	Walker A/P-loop; other site
1271752002885	ATP binding site [chemical binding]; other site
1271752002886	Q-loop/lid; other site
1271752002887	ABC transporter signature motif; other site
1271752002888	Walker B; other site
1271752002889	D-loop; other site
1271752002890	H-loop/switch region; other site
1271752002891	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1271752002892	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1271752002893	generic binding surface II; other site
1271752002894	ssDNA binding site; other site
1271752002895	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1271752002896	ATP binding site [chemical binding]; other site
1271752002897	putative Mg++ binding site [ion binding]; other site
1271752002898	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1271752002899	nucleotide binding region [chemical binding]; other site
1271752002900	ATP-binding site [chemical binding]; other site
1271752002901	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1271752002902	RNA binding surface [nucleotide binding]; other site
1271752002903	shikimate kinase; Reviewed; Region: aroK; PRK00131
1271752002904	shikimate kinase II; Reviewed; Region: aroL; cl17327
1271752002905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1271752002906	S-adenosylmethionine binding site [chemical binding]; other site
1271752002907	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1271752002908	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1271752002909	ligand binding site [chemical binding]; other site
1271752002910	hypothetical protein; Provisional; Region: PRK08201
1271752002911	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
1271752002912	metal binding site [ion binding]; metal-binding site
1271752002913	putative dimer interface [polypeptide binding]; other site
1271752002914	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
1271752002915	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1271752002916	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1271752002917	S-adenosylmethionine binding site [chemical binding]; other site
1271752002918	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
1271752002919	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
1271752002920	dimerization interface [polypeptide binding]; other site
1271752002921	putative ATP binding site [chemical binding]; other site
1271752002922	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1271752002923	thiamine phosphate binding site [chemical binding]; other site
1271752002924	active site
1271752002925	pyrophosphate binding site [ion binding]; other site
1271752002926	Trm112p-like protein; Region: Trm112p; cl01066
1271752002927	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1271752002928	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1271752002929	substrate binding pocket [chemical binding]; other site
1271752002930	chain length determination region; other site
1271752002931	substrate-Mg2+ binding site; other site
1271752002932	catalytic residues [active]
1271752002933	aspartate-rich region 1; other site
1271752002934	active site lid residues [active]
1271752002935	aspartate-rich region 2; other site
1271752002936	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1271752002937	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1271752002938	NAD(P) binding site [chemical binding]; other site
1271752002939	active site
1271752002940	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1271752002941	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1271752002942	PrcB C-terminal; Region: PrcB_C; pfam14343
1271752002943	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1271752002944	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1271752002945	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1271752002946	catalytic residue [active]
1271752002947	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1271752002948	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1271752002949	catalytic residues [active]
1271752002950	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1271752002951	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1271752002952	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
1271752002953	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1271752002954	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1271752002955	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1271752002956	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1271752002957	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
1271752002958	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1271752002959	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1271752002960	dimer interface [polypeptide binding]; other site
1271752002961	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752002962	catalytic residue [active]
1271752002963	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1271752002964	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1271752002965	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1271752002966	substrate-cofactor binding pocket; other site
1271752002967	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752002968	catalytic residue [active]
1271752002969	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1271752002970	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1271752002971	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1271752002972	primosomal protein N' Region: priA; TIGR00595
1271752002973	ATP binding site [chemical binding]; other site
1271752002974	putative Mg++ binding site [ion binding]; other site
1271752002975	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1271752002976	Domain of unknown function (DUF955); Region: DUF955; cl01076
1271752002977	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1271752002978	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1271752002979	nucleotide binding site [chemical binding]; other site
1271752002980	NEF interaction site [polypeptide binding]; other site
1271752002981	SBD interface [polypeptide binding]; other site
1271752002982	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1271752002983	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
1271752002984	putative ion selectivity filter; other site
1271752002985	putative pore gating glutamate residue; other site
1271752002986	putative H+/Cl- coupling transport residue; other site
1271752002987	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1271752002988	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1271752002989	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1271752002990	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1271752002991	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1271752002992	WYL domain; Region: WYL; pfam13280
1271752002993	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1271752002994	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1271752002995	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1271752002996	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1271752002997	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1271752002998	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
1271752002999	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1271752003000	FeS/SAM binding site; other site
1271752003001	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1271752003002	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1271752003003	ATP binding site [chemical binding]; other site
1271752003004	Mg++ binding site [ion binding]; other site
1271752003005	motif III; other site
1271752003006	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1271752003007	nucleotide binding region [chemical binding]; other site
1271752003008	ATP-binding site [chemical binding]; other site
1271752003009	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1271752003010	DNA-binding site [nucleotide binding]; DNA binding site
1271752003011	RNA-binding motif; other site
1271752003012	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1271752003013	DNA-binding site [nucleotide binding]; DNA binding site
1271752003014	RNA-binding motif; other site
1271752003015	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
1271752003016	active site
1271752003017	homodimer interface [polypeptide binding]; other site
1271752003018	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1271752003019	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1271752003020	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1271752003021	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1271752003022	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1271752003023	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1271752003024	catalytic site [active]
1271752003025	subunit interface [polypeptide binding]; other site
1271752003026	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1271752003027	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1271752003028	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1271752003029	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1271752003030	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1271752003031	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1271752003032	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1271752003033	IMP binding site; other site
1271752003034	dimer interface [polypeptide binding]; other site
1271752003035	interdomain contacts; other site
1271752003036	partial ornithine binding site; other site
1271752003037	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1271752003038	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1271752003039	Walker A/P-loop; other site
1271752003040	ATP binding site [chemical binding]; other site
1271752003041	Q-loop/lid; other site
1271752003042	ABC transporter signature motif; other site
1271752003043	Walker B; other site
1271752003044	D-loop; other site
1271752003045	H-loop/switch region; other site
1271752003046	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1271752003047	ABC-ATPase subunit  interface; other site
1271752003048	dimer interface [polypeptide binding]; other site
1271752003049	putative PBP binding regions; other site
1271752003050	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1271752003051	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1271752003052	catalytic residues [active]
1271752003053	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1271752003054	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1271752003055	FAD binding pocket [chemical binding]; other site
1271752003056	FAD binding motif [chemical binding]; other site
1271752003057	phosphate binding motif [ion binding]; other site
1271752003058	beta-alpha-beta structure motif; other site
1271752003059	NAD(p) ribose binding residues [chemical binding]; other site
1271752003060	NAD binding pocket [chemical binding]; other site
1271752003061	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1271752003062	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1271752003063	catalytic loop [active]
1271752003064	iron binding site [ion binding]; other site
1271752003065	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1271752003066	putative active site [active]
1271752003067	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
1271752003068	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1271752003069	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
1271752003070	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1271752003071	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1271752003072	active site
1271752003073	HIGH motif; other site
1271752003074	nucleotide binding site [chemical binding]; other site
1271752003075	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1271752003076	active site
1271752003077	KMSKS motif; other site
1271752003078	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1271752003079	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1271752003080	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1271752003081	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1271752003082	YceG-like family; Region: YceG; pfam02618
1271752003083	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
1271752003084	dimerization interface [polypeptide binding]; other site
1271752003085	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1271752003086	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1271752003087	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752003088	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1271752003089	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1271752003090	DNA binding site [nucleotide binding]
1271752003091	active site
1271752003092	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1271752003093	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1271752003094	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1271752003095	active site
1271752003096	metal binding site [ion binding]; metal-binding site
1271752003097	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752003098	Recombination protein O N terminal; Region: RecO_N; pfam11967
1271752003099	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
1271752003100	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1271752003101	active site
1271752003102	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1271752003103	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1271752003104	putative substrate translocation pore; other site
1271752003105	ATP synthase A chain; Region: ATP-synt_A; cl00413
1271752003106	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1271752003107	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1271752003108	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1271752003109	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1271752003110	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1271752003111	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1271752003112	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1271752003113	beta subunit interaction interface [polypeptide binding]; other site
1271752003114	Walker A motif; other site
1271752003115	ATP binding site [chemical binding]; other site
1271752003116	Walker B motif; other site
1271752003117	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1271752003118	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1271752003119	core domain interface [polypeptide binding]; other site
1271752003120	delta subunit interface [polypeptide binding]; other site
1271752003121	epsilon subunit interface [polypeptide binding]; other site
1271752003122	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1271752003123	Domain of unknown function DUF21; Region: DUF21; pfam01595
1271752003124	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1271752003125	Transporter associated domain; Region: CorC_HlyC; smart01091
1271752003126	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
1271752003127	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1271752003128	hydrophobic ligand binding site; other site
1271752003129	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1271752003130	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1271752003131	TPP-binding site [chemical binding]; other site
1271752003132	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1271752003133	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1271752003134	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1271752003135	E3 interaction surface; other site
1271752003136	lipoyl attachment site [posttranslational modification]; other site
1271752003137	e3 binding domain; Region: E3_binding; pfam02817
1271752003138	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1271752003139	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1271752003140	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1271752003141	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1271752003142	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1271752003143	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
1271752003144	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1271752003145	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
1271752003146	recombination protein F; Reviewed; Region: recF; PRK00064
1271752003147	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1271752003148	Walker A/P-loop; other site
1271752003149	ATP binding site [chemical binding]; other site
1271752003150	Q-loop/lid; other site
1271752003151	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1271752003152	ABC transporter signature motif; other site
1271752003153	Walker B; other site
1271752003154	D-loop; other site
1271752003155	H-loop/switch region; other site
1271752003156	Cna protein B-type domain; Region: Cna_B_2; pfam13715
1271752003157	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1271752003158	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1271752003159	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
1271752003160	Putative zinc ribbon domain; Region: DUF164; pfam02591
1271752003161	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1271752003162	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1271752003163	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1271752003164	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1271752003165	Ion transport protein; Region: Ion_trans; pfam00520
1271752003166	Ion channel; Region: Ion_trans_2; pfam07885
1271752003167	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1271752003168	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1271752003169	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1271752003170	G1 box; other site
1271752003171	putative GEF interaction site [polypeptide binding]; other site
1271752003172	GTP/Mg2+ binding site [chemical binding]; other site
1271752003173	Switch I region; other site
1271752003174	G2 box; other site
1271752003175	G3 box; other site
1271752003176	Switch II region; other site
1271752003177	G4 box; other site
1271752003178	G5 box; other site
1271752003179	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1271752003180	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1271752003181	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1271752003182	acyl-activating enzyme (AAE) consensus motif; other site
1271752003183	putative AMP binding site [chemical binding]; other site
1271752003184	putative active site [active]
1271752003185	putative CoA binding site [chemical binding]; other site
1271752003186	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1271752003187	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1271752003188	FAD binding site [chemical binding]; other site
1271752003189	homotetramer interface [polypeptide binding]; other site
1271752003190	substrate binding pocket [chemical binding]; other site
1271752003191	catalytic base [active]
1271752003192	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1271752003193	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1271752003194	dimer interface [polypeptide binding]; other site
1271752003195	active site
1271752003196	metal binding site [ion binding]; metal-binding site
1271752003197	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752003198	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1271752003199	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1271752003200	ATP binding site [chemical binding]; other site
1271752003201	Mg++ binding site [ion binding]; other site
1271752003202	motif III; other site
1271752003203	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1271752003204	nucleotide binding region [chemical binding]; other site
1271752003205	ATP-binding site [chemical binding]; other site
1271752003206	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1271752003207	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1271752003208	active site
1271752003209	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
1271752003210	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1271752003211	active site
1271752003212	HIGH motif; other site
1271752003213	KMSKS motif; other site
1271752003214	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1271752003215	tRNA binding surface [nucleotide binding]; other site
1271752003216	anticodon binding site; other site
1271752003217	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1271752003218	dimer interface [polypeptide binding]; other site
1271752003219	putative tRNA-binding site [nucleotide binding]; other site
1271752003220	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1271752003221	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
1271752003222	tetramer interface [polypeptide binding]; other site
1271752003223	active site
1271752003224	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1271752003225	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1271752003226	intersubunit interface [polypeptide binding]; other site
1271752003227	Domain of unknown function (DUF4268); Region: DUF4268; pfam14088
1271752003228	Peptidase S46; Region: Peptidase_S46; pfam10459
1271752003229	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1271752003230	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1271752003231	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1271752003232	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1271752003233	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1271752003234	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1271752003235	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1271752003236	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
1271752003237	tetramer interface [polypeptide binding]; other site
1271752003238	TPP-binding site [chemical binding]; other site
1271752003239	heterodimer interface [polypeptide binding]; other site
1271752003240	phosphorylation loop region [posttranslational modification]
1271752003241	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1271752003242	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1271752003243	PYR/PP interface [polypeptide binding]; other site
1271752003244	dimer interface [polypeptide binding]; other site
1271752003245	TPP binding site [chemical binding]; other site
1271752003246	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1271752003247	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1271752003248	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1271752003249	inhibitor-cofactor binding pocket; inhibition site
1271752003250	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752003251	catalytic residue [active]
1271752003252	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1271752003253	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1271752003254	NAD binding site [chemical binding]; other site
1271752003255	homodimer interface [polypeptide binding]; other site
1271752003256	active site
1271752003257	substrate binding site [chemical binding]; other site
1271752003258	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1271752003259	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1271752003260	active site
1271752003261	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
1271752003262	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1271752003263	S-adenosylmethionine binding site [chemical binding]; other site
1271752003264	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1271752003265	DNA polymerase III subunit beta; Validated; Region: PRK05643
1271752003266	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1271752003267	putative DNA binding surface [nucleotide binding]; other site
1271752003268	dimer interface [polypeptide binding]; other site
1271752003269	beta-clamp/clamp loader binding surface; other site
1271752003270	beta-clamp/translesion DNA polymerase binding surface; other site
1271752003271	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1271752003272	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1271752003273	putative tRNA-binding site [nucleotide binding]; other site
1271752003274	B3/4 domain; Region: B3_4; pfam03483
1271752003275	tRNA synthetase B5 domain; Region: B5; pfam03484
1271752003276	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1271752003277	dimer interface [polypeptide binding]; other site
1271752003278	motif 1; other site
1271752003279	motif 3; other site
1271752003280	motif 2; other site
1271752003281	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1271752003282	META domain; Region: META; pfam03724
1271752003283	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1271752003284	oligomerisation interface [polypeptide binding]; other site
1271752003285	mobile loop; other site
1271752003286	roof hairpin; other site
1271752003287	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1271752003288	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1271752003289	ring oligomerisation interface [polypeptide binding]; other site
1271752003290	ATP/Mg binding site [chemical binding]; other site
1271752003291	stacking interactions; other site
1271752003292	hinge regions; other site
1271752003293	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1271752003294	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1271752003295	NAD(P) binding site [chemical binding]; other site
1271752003296	active site
1271752003297	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1271752003298	Coenzyme A binding pocket [chemical binding]; other site
1271752003299	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1271752003300	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1271752003301	PYR/PP interface [polypeptide binding]; other site
1271752003302	dimer interface [polypeptide binding]; other site
1271752003303	TPP binding site [chemical binding]; other site
1271752003304	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1271752003305	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1271752003306	active site
1271752003307	homotetramer interface [polypeptide binding]; other site
1271752003308	Domain of unknown function (DUF336); Region: DUF336; cl01249
1271752003309	Domain of unknown function (DUF336); Region: DUF336; pfam03928
1271752003310	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1271752003311	active site
1271752003312	homotetramer interface [polypeptide binding]; other site
1271752003313	Domain of unknown function (DUF336); Region: DUF336; cl01249
1271752003314	Predicted membrane protein [Function unknown]; Region: COG3059
1271752003315	Domain of unknown function (DUF336); Region: DUF336; pfam03928
1271752003316	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1271752003317	transketolase; Reviewed; Region: PRK05899
1271752003318	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1271752003319	TPP-binding site [chemical binding]; other site
1271752003320	dimer interface [polypeptide binding]; other site
1271752003321	Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326
1271752003322	Na binding site [ion binding]; other site
1271752003323	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1271752003324	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1271752003325	FeS/SAM binding site; other site
1271752003326	HemN C-terminal domain; Region: HemN_C; pfam06969
1271752003327	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1271752003328	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1271752003329	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1271752003330	Protein export membrane protein; Region: SecD_SecF; pfam02355
1271752003331	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1271752003332	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1271752003333	TrkA-C domain; Region: TrkA_C; pfam02080
1271752003334	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1271752003335	Ligand Binding Site [chemical binding]; other site
1271752003336	prephenate dehydratase; Provisional; Region: PRK11898
1271752003337	Prephenate dehydratase; Region: PDT; pfam00800
1271752003338	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1271752003339	putative L-Phe binding site [chemical binding]; other site
1271752003340	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1271752003341	active site
1271752003342	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1271752003343	active site
1271752003344	motif I; other site
1271752003345	motif II; other site
1271752003346	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
1271752003347	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1271752003348	Isochorismatase family; Region: Isochorismatase; pfam00857
1271752003349	catalytic triad [active]
1271752003350	metal binding site [ion binding]; metal-binding site
1271752003351	conserved cis-peptide bond; other site
1271752003352	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1271752003353	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1271752003354	dimer interface [polypeptide binding]; other site
1271752003355	motif 1; other site
1271752003356	active site
1271752003357	motif 2; other site
1271752003358	motif 3; other site
1271752003359	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1271752003360	anticodon binding site; other site
1271752003361	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1271752003362	ArsC family; Region: ArsC; pfam03960
1271752003363	catalytic residues [active]
1271752003364	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
1271752003365	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1271752003366	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1271752003367	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1271752003368	putative acyl-acceptor binding pocket; other site
1271752003369	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1271752003370	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1271752003371	Probable Catalytic site; other site
1271752003372	metal-binding site
1271752003373	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
1271752003374	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1271752003375	DNA binding residues [nucleotide binding]
1271752003376	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1271752003377	Coenzyme A binding pocket [chemical binding]; other site
1271752003378	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1271752003379	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1271752003380	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1271752003381	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1271752003382	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1271752003383	active site
1271752003384	catalytic motif [active]
1271752003385	Zn binding site [ion binding]; other site
1271752003386	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
1271752003387	metal binding site [ion binding]; metal-binding site
1271752003388	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1271752003389	catalytic residues [active]
1271752003390	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
1271752003391	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1271752003392	TAP-like protein; Region: Abhydrolase_4; pfam08386
1271752003393	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1271752003394	non-specific DNA binding site [nucleotide binding]; other site
1271752003395	salt bridge; other site
1271752003396	sequence-specific DNA binding site [nucleotide binding]; other site
1271752003397	Integral membrane protein TerC family; Region: TerC; cl10468
1271752003398	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239
1271752003399	putative active site [active]
1271752003400	Zn binding site [ion binding]; other site
1271752003401	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
1271752003402	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1271752003403	S-adenosylmethionine binding site [chemical binding]; other site
1271752003404	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1271752003405	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1271752003406	E3 interaction surface; other site
1271752003407	lipoyl attachment site [posttranslational modification]; other site
1271752003408	e3 binding domain; Region: E3_binding; pfam02817
1271752003409	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1271752003410	hypothetical protein; Provisional; Region: PRK06753
1271752003411	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1271752003412	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
1271752003413	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1271752003414	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1271752003415	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1271752003416	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1271752003417	active site
1271752003418	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
1271752003419	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1271752003420	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1271752003421	active site
1271752003422	DNA binding site [nucleotide binding]
1271752003423	Int/Topo IB signature motif; other site
1271752003424	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1271752003425	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1271752003426	dimer interface [polypeptide binding]; other site
1271752003427	ssDNA binding site [nucleotide binding]; other site
1271752003428	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1271752003429	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1271752003430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1271752003431	ATP binding site [chemical binding]; other site
1271752003432	Mg2+ binding site [ion binding]; other site
1271752003433	G-X-G motif; other site
1271752003434	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1271752003435	anchoring element; other site
1271752003436	dimer interface [polypeptide binding]; other site
1271752003437	ATP binding site [chemical binding]; other site
1271752003438	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1271752003439	active site
1271752003440	putative metal-binding site [ion binding]; other site
1271752003441	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1271752003442	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
1271752003443	DNA gyrase subunit A; Validated; Region: PRK05560
1271752003444	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1271752003445	CAP-like domain; other site
1271752003446	active site
1271752003447	primary dimer interface [polypeptide binding]; other site
1271752003448	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1271752003449	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1271752003450	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1271752003451	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1271752003452	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1271752003453	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1271752003454	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1271752003455	TPR motif; other site
1271752003456	binding surface
1271752003457	TPR repeat; Region: TPR_11; pfam13414
1271752003458	YtxH-like protein; Region: YtxH; cl02079
1271752003459	helicase 45; Provisional; Region: PTZ00424
1271752003460	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1271752003461	ATP binding site [chemical binding]; other site
1271752003462	Mg++ binding site [ion binding]; other site
1271752003463	motif III; other site
1271752003464	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1271752003465	nucleotide binding region [chemical binding]; other site
1271752003466	ATP-binding site [chemical binding]; other site
1271752003467	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
1271752003468	RNA binding site [nucleotide binding]; other site
1271752003469	acetyl-CoA synthetase; Provisional; Region: PRK00174
1271752003470	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1271752003471	active site
1271752003472	CoA binding site [chemical binding]; other site
1271752003473	acyl-activating enzyme (AAE) consensus motif; other site
1271752003474	AMP binding site [chemical binding]; other site
1271752003475	acetate binding site [chemical binding]; other site
1271752003476	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1271752003477	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1271752003478	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1271752003479	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1271752003480	active site
1271752003481	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
1271752003482	RNAase interaction site [polypeptide binding]; other site
1271752003483	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
1271752003484	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1271752003485	active site
1271752003486	Zn binding site [ion binding]; other site
1271752003487	Cna protein B-type domain; Region: Cna_B_2; pfam13715
1271752003488	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1271752003489	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1271752003490	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1271752003491	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1271752003492	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1271752003493	UbiA prenyltransferase family; Region: UbiA; pfam01040
1271752003494	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1271752003495	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1271752003496	substrate binding site [chemical binding]; other site
1271752003497	oxyanion hole (OAH) forming residues; other site
1271752003498	trimer interface [polypeptide binding]; other site
1271752003499	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1271752003500	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1271752003501	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
1271752003502	HlyD family secretion protein; Region: HlyD_3; pfam13437
1271752003503	Outer membrane efflux protein; Region: OEP; pfam02321
1271752003504	Outer membrane efflux protein; Region: OEP; pfam02321
1271752003505	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
1271752003506	Cytochrome c; Region: Cytochrom_C; cl11414
1271752003507	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1271752003508	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1271752003509	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1271752003510	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
1271752003511	active site
1271752003512	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1271752003513	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1271752003514	RNA binding site [nucleotide binding]; other site
1271752003515	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1271752003516	RNA binding site [nucleotide binding]; other site
1271752003517	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1271752003518	RNA binding site [nucleotide binding]; other site
1271752003519	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1271752003520	RNA binding site [nucleotide binding]; other site
1271752003521	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1271752003522	RNA binding site [nucleotide binding]; other site
1271752003523	S1 RNA binding domain; Region: S1; pfam00575
1271752003524	RNA binding site [nucleotide binding]; other site
1271752003525	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1271752003526	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
1271752003527	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1271752003528	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1271752003529	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1271752003530	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1271752003531	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1271752003532	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1271752003533	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1271752003534	purine monophosphate binding site [chemical binding]; other site
1271752003535	dimer interface [polypeptide binding]; other site
1271752003536	putative catalytic residues [active]
1271752003537	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1271752003538	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1271752003539	hypothetical protein; Validated; Region: PRK02101
1271752003540	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1271752003541	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1271752003542	S-adenosylmethionine binding site [chemical binding]; other site
1271752003543	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1271752003544	signal recognition particle protein; Provisional; Region: PRK10867
1271752003545	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1271752003546	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1271752003547	P loop; other site
1271752003548	GTP binding site [chemical binding]; other site
1271752003549	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1271752003550	Sodium Bile acid symporter family; Region: SBF; cl17470
1271752003551	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1271752003552	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1271752003553	dimerization interface [polypeptide binding]; other site
1271752003554	putative DNA binding site [nucleotide binding]; other site
1271752003555	putative Zn2+ binding site [ion binding]; other site
1271752003556	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
1271752003557	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
1271752003558	triosephosphate isomerase; Provisional; Region: PRK14567
1271752003559	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1271752003560	substrate binding site [chemical binding]; other site
1271752003561	dimer interface [polypeptide binding]; other site
1271752003562	catalytic triad [active]
1271752003563	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1271752003564	Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
1271752003565	GTPase RsgA; Reviewed; Region: PRK00098
1271752003566	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1271752003567	RNA binding site [nucleotide binding]; other site
1271752003568	homodimer interface [polypeptide binding]; other site
1271752003569	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1271752003570	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1271752003571	GTP/Mg2+ binding site [chemical binding]; other site
1271752003572	G4 box; other site
1271752003573	G5 box; other site
1271752003574	G1 box; other site
1271752003575	Switch I region; other site
1271752003576	G2 box; other site
1271752003577	G3 box; other site
1271752003578	Switch II region; other site
1271752003579	Septum formation initiator; Region: DivIC; cl17659
1271752003580	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1271752003581	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1271752003582	ATP-binding site [chemical binding]; other site
1271752003583	Sugar specificity; other site
1271752003584	Pyrimidine base specificity; other site
1271752003585	Protein of unknown function (DUF465); Region: DUF465; cl01070
1271752003586	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1271752003587	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
1271752003588	G1 box; other site
1271752003589	putative GEF interaction site [polypeptide binding]; other site
1271752003590	GTP/Mg2+ binding site [chemical binding]; other site
1271752003591	Switch I region; other site
1271752003592	G2 box; other site
1271752003593	G3 box; other site
1271752003594	Switch II region; other site
1271752003595	G4 box; other site
1271752003596	G5 box; other site
1271752003597	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1271752003598	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1271752003599	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
1271752003600	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1271752003601	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1271752003602	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1271752003603	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1271752003604	GDP-binding site [chemical binding]; other site
1271752003605	ACT binding site; other site
1271752003606	IMP binding site; other site
1271752003607	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
1271752003608	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1271752003609	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1271752003610	dimer interface [polypeptide binding]; other site
1271752003611	putative anticodon binding site; other site
1271752003612	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1271752003613	motif 1; other site
1271752003614	active site
1271752003615	motif 2; other site
1271752003616	motif 3; other site
1271752003617	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
1271752003618	putative active site [active]
1271752003619	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1271752003620	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1271752003621	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1271752003622	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
1271752003623	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1271752003624	active site
1271752003625	tetramer interface [polypeptide binding]; other site
1271752003626	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1271752003627	active site
1271752003628	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1271752003629	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1271752003630	ATP binding site [chemical binding]; other site
1271752003631	active site
1271752003632	substrate binding site [chemical binding]; other site
1271752003633	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
1271752003634	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
1271752003635	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1271752003636	dimerization interface [polypeptide binding]; other site
1271752003637	ATP binding site [chemical binding]; other site
1271752003638	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1271752003639	dimerization interface [polypeptide binding]; other site
1271752003640	ATP binding site [chemical binding]; other site
1271752003641	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1271752003642	putative active site [active]
1271752003643	catalytic triad [active]
1271752003644	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
1271752003645	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1271752003646	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1271752003647	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1271752003648	23S rRNA binding site [nucleotide binding]; other site
1271752003649	L21 binding site [polypeptide binding]; other site
1271752003650	L13 binding site [polypeptide binding]; other site
1271752003651	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1271752003652	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1271752003653	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1271752003654	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1271752003655	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1271752003656	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1271752003657	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1271752003658	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1271752003659	active site
1271752003660	dimer interface [polypeptide binding]; other site
1271752003661	motif 1; other site
1271752003662	motif 2; other site
1271752003663	motif 3; other site
1271752003664	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1271752003665	anticodon binding site; other site
1271752003666	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1271752003667	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1271752003668	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1271752003669	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1271752003670	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1271752003671	glutamine binding [chemical binding]; other site
1271752003672	catalytic triad [active]
1271752003673	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1271752003674	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1271752003675	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1271752003676	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1271752003677	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1271752003678	active site
1271752003679	ribulose/triose binding site [chemical binding]; other site
1271752003680	phosphate binding site [ion binding]; other site
1271752003681	substrate (anthranilate) binding pocket [chemical binding]; other site
1271752003682	product (indole) binding pocket [chemical binding]; other site
1271752003683	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1271752003684	active site
1271752003685	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1271752003686	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1271752003687	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752003688	catalytic residue [active]
1271752003689	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1271752003690	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1271752003691	substrate binding site [chemical binding]; other site
1271752003692	active site
1271752003693	catalytic residues [active]
1271752003694	heterodimer interface [polypeptide binding]; other site
1271752003695	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1271752003696	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1271752003697	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
1271752003698	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1271752003699	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1271752003700	Zn2+ binding site [ion binding]; other site
1271752003701	Mg2+ binding site [ion binding]; other site
1271752003702	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1271752003703	synthetase active site [active]
1271752003704	NTP binding site [chemical binding]; other site
1271752003705	metal binding site [ion binding]; metal-binding site
1271752003706	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1271752003707	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1271752003708	DNA topoisomerase IV subunit A; Provisional; Region: PRK12758
1271752003709	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
1271752003710	CAP-like domain; other site
1271752003711	active site
1271752003712	primary dimer interface [polypeptide binding]; other site
1271752003713	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1271752003714	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1271752003715	ATP binding site [chemical binding]; other site
1271752003716	Mg2+ binding site [ion binding]; other site
1271752003717	G-X-G motif; other site
1271752003718	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1271752003719	anchoring element; other site
1271752003720	dimer interface [polypeptide binding]; other site
1271752003721	ATP binding site [chemical binding]; other site
1271752003722	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
1271752003723	active site
1271752003724	putative metal-binding site [ion binding]; other site
1271752003725	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1271752003726	Cell division protein ZapA; Region: ZapA; pfam05164
1271752003727	phosphodiesterase; Provisional; Region: PRK12704
1271752003728	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1271752003729	Zn2+ binding site [ion binding]; other site
1271752003730	Mg2+ binding site [ion binding]; other site
1271752003731	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
1271752003732	putative rRNA binding site [nucleotide binding]; other site
1271752003733	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1271752003734	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1271752003735	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
1271752003736	Interdomain contacts; other site
1271752003737	Cytokine receptor motif; other site
1271752003738	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1271752003739	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1271752003740	active site
1271752003741	metal binding site [ion binding]; metal-binding site
1271752003742	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752003743	YhhN-like protein; Region: YhhN; pfam07947
1271752003744	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1271752003745	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1271752003746	Potassium binding sites [ion binding]; other site
1271752003747	Cesium cation binding sites [ion binding]; other site
1271752003748	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1271752003749	GTPase Era; Reviewed; Region: era; PRK00089
1271752003750	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1271752003751	G1 box; other site
1271752003752	GTP/Mg2+ binding site [chemical binding]; other site
1271752003753	Switch I region; other site
1271752003754	G2 box; other site
1271752003755	Switch II region; other site
1271752003756	G3 box; other site
1271752003757	G4 box; other site
1271752003758	G5 box; other site
1271752003759	KH domain; Region: KH_2; pfam07650
1271752003760	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1271752003761	PhoH-like protein; Region: PhoH; pfam02562
1271752003762	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1271752003763	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1271752003764	DXD motif; other site
1271752003765	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
1271752003766	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
1271752003767	DNA polymerase I; Provisional; Region: PRK05755
1271752003768	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1271752003769	active site
1271752003770	metal binding site 1 [ion binding]; metal-binding site
1271752003771	putative 5' ssDNA interaction site; other site
1271752003772	metal binding site 3; metal-binding site
1271752003773	metal binding site 2 [ion binding]; metal-binding site
1271752003774	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1271752003775	putative DNA binding site [nucleotide binding]; other site
1271752003776	putative metal binding site [ion binding]; other site
1271752003777	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1271752003778	active site
1271752003779	catalytic site [active]
1271752003780	substrate binding site [chemical binding]; other site
1271752003781	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1271752003782	active site
1271752003783	DNA binding site [nucleotide binding]
1271752003784	catalytic site [active]
1271752003785	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1271752003786	Part of AAA domain; Region: AAA_19; pfam13245
1271752003787	Family description; Region: UvrD_C_2; pfam13538
1271752003788	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1271752003789	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1271752003790	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1271752003791	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1271752003792	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1271752003793	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1271752003794	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1271752003795	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1271752003796	Probable Catalytic site; other site
1271752003797	metal-binding site
1271752003798	recombination protein RecR; Reviewed; Region: recR; PRK00076
1271752003799	RecR protein; Region: RecR; pfam02132
1271752003800	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1271752003801	putative active site [active]
1271752003802	putative metal-binding site [ion binding]; other site
1271752003803	tetramer interface [polypeptide binding]; other site
1271752003804	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
1271752003805	active site
1271752003806	catalytic triad [active]
1271752003807	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
1271752003808	FOG: PKD repeat [General function prediction only]; Region: COG3291
1271752003809	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
1271752003810	Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675
1271752003811	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752003812	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1271752003813	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
1271752003814	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
1271752003815	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1271752003816	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1271752003817	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1271752003818	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1271752003819	Zn binding site [ion binding]; other site
1271752003820	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1271752003821	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
1271752003822	Walker A/P-loop; other site
1271752003823	ATP binding site [chemical binding]; other site
1271752003824	Q-loop/lid; other site
1271752003825	ABC transporter signature motif; other site
1271752003826	Walker B; other site
1271752003827	D-loop; other site
1271752003828	H-loop/switch region; other site
1271752003829	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1271752003830	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1271752003831	RNA binding surface [nucleotide binding]; other site
1271752003832	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1271752003833	active site
1271752003834	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1271752003835	asparagine synthetase B; Provisional; Region: asnB; PRK09431
1271752003836	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1271752003837	active site
1271752003838	dimer interface [polypeptide binding]; other site
1271752003839	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1271752003840	Ligand Binding Site [chemical binding]; other site
1271752003841	Molecular Tunnel; other site
1271752003842	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1271752003843	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1271752003844	dimer interface [polypeptide binding]; other site
1271752003845	anticodon binding site; other site
1271752003846	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1271752003847	homodimer interface [polypeptide binding]; other site
1271752003848	motif 1; other site
1271752003849	active site
1271752003850	motif 2; other site
1271752003851	GAD domain; Region: GAD; pfam02938
1271752003852	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1271752003853	active site
1271752003854	motif 3; other site
1271752003855	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1271752003856	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1271752003857	active site
1271752003858	substrate binding site [chemical binding]; other site
1271752003859	cosubstrate binding site; other site
1271752003860	catalytic site [active]
1271752003861	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1271752003862	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1271752003863	dimerization interface [polypeptide binding]; other site
1271752003864	putative ATP binding site [chemical binding]; other site
1271752003865	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1271752003866	active site
1271752003867	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1271752003868	active site
1271752003869	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1271752003870	catalytic residues [active]
1271752003871	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
1271752003872	FOG: PKD repeat [General function prediction only]; Region: COG3291
1271752003873	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
1271752003874	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752003875	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1271752003876	active site
1271752003877	catalytic residues [active]
1271752003878	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1271752003879	active site
1271752003880	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1271752003881	active site
1271752003882	dimer interface [polypeptide binding]; other site
1271752003883	NlpE N-terminal domain; Region: NlpE; pfam04170
1271752003884	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1271752003885	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
1271752003886	ligand binding site [chemical binding]; other site
1271752003887	flexible hinge region; other site
1271752003888	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1271752003889	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1271752003890	S1 domain; Region: S1_2; pfam13509
1271752003891	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1271752003892	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1271752003893	non-specific DNA binding site [nucleotide binding]; other site
1271752003894	salt bridge; other site
1271752003895	sequence-specific DNA binding site [nucleotide binding]; other site
1271752003896	AntA/AntB antirepressor; Region: AntA; cl01430
1271752003897	Helix-turn-helix domain; Region: HTH_17; pfam12728
1271752003898	Fic family protein [Function unknown]; Region: COG3177
1271752003899	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
1271752003900	Fic/DOC family; Region: Fic; pfam02661
1271752003901	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1271752003902	active site
1271752003903	DNA binding site [nucleotide binding]
1271752003904	Int/Topo IB signature motif; other site
1271752003905	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752003906	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1271752003907	binding surface
1271752003908	TPR motif; other site
1271752003909	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1271752003910	binding surface
1271752003911	TPR motif; other site
1271752003912	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1271752003913	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1271752003914	binding surface
1271752003915	TPR motif; other site
1271752003916	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1271752003917	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
1271752003918	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1271752003919	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1271752003920	TPR motif; other site
1271752003921	binding surface
1271752003922	phosphoglyceromutase; Provisional; Region: PRK05434
1271752003923	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1271752003924	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1271752003925	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1271752003926	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1271752003927	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1271752003928	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
1271752003929	active site
1271752003930	metal binding site [ion binding]; metal-binding site
1271752003931	nudix motif; other site
1271752003932	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752003933	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1271752003934	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1271752003935	oligomer interface [polypeptide binding]; other site
1271752003936	active site
1271752003937	metal binding site [ion binding]; metal-binding site
1271752003938	Domain of unknown function (DUF4294); Region: DUF4294; pfam14127
1271752003939	Protein of unknown function (DUF493); Region: DUF493; pfam04359
1271752003940	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
1271752003941	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1271752003942	Zn2+ binding site [ion binding]; other site
1271752003943	Mg2+ binding site [ion binding]; other site
1271752003944	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1271752003945	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1271752003946	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1271752003947	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
1271752003948	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1271752003949	NAD(P) binding site [chemical binding]; other site
1271752003950	catalytic residues [active]
1271752003951	4Fe-4S binding domain; Region: Fer4; pfam00037
1271752003952	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
1271752003953	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1271752003954	catalytic residue [active]
1271752003955	Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303
1271752003956	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1271752003957	putative ligand binding site [chemical binding]; other site
1271752003958	NAD binding site [chemical binding]; other site
1271752003959	dimerization interface [polypeptide binding]; other site
1271752003960	catalytic site [active]
1271752003961	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
1271752003962	Uncharacterized conserved protein [Function unknown]; Region: COG4198
1271752003963	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1271752003964	GMP synthase; Reviewed; Region: guaA; PRK00074
1271752003965	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1271752003966	AMP/PPi binding site [chemical binding]; other site
1271752003967	candidate oxyanion hole; other site
1271752003968	catalytic triad [active]
1271752003969	potential glutamine specificity residues [chemical binding]; other site
1271752003970	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1271752003971	ATP Binding subdomain [chemical binding]; other site
1271752003972	Ligand Binding sites [chemical binding]; other site
1271752003973	Dimerization subdomain; other site
1271752003974	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1271752003975	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1271752003976	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1271752003977	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1271752003978	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1271752003979	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1271752003980	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
1271752003981	putative active site [active]
1271752003982	putative catalytic site [active]
1271752003983	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1271752003984	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1271752003985	Ligand binding site; other site
1271752003986	Putative Catalytic site; other site
1271752003987	DXD motif; other site
1271752003988	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1271752003989	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
1271752003990	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1271752003991	trimer interface [polypeptide binding]; other site
1271752003992	active site
1271752003993	substrate binding site [chemical binding]; other site
1271752003994	CoA binding site [chemical binding]; other site
1271752003995	NlpC/P60 family; Region: NLPC_P60; pfam00877
1271752003996	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
1271752003997	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1271752003998	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1271752003999	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1271752004000	Substrate-binding site [chemical binding]; other site
1271752004001	Substrate specificity [chemical binding]; other site
1271752004002	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
1271752004003	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1271752004004	DNA polymerase III, delta subunit; Region: holA; TIGR01128
1271752004005	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
1271752004006	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1271752004007	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1271752004008	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1271752004009	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1271752004010	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1271752004011	Predicted permeases [General function prediction only]; Region: COG0795
1271752004012	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1271752004013	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1271752004014	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1271752004015	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1271752004016	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1271752004017	P-loop; other site
1271752004018	Magnesium ion binding site [ion binding]; other site
1271752004019	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1271752004020	Magnesium ion binding site [ion binding]; other site
1271752004021	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1271752004022	ParB-like nuclease domain; Region: ParB; smart00470
1271752004023	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
1271752004024	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1271752004025	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1271752004026	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1271752004027	Catalytic site [active]
1271752004028	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1271752004029	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1271752004030	WbqC-like protein family; Region: WbqC; pfam08889
1271752004031	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1271752004032	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1271752004033	active site
1271752004034	catalytic residues [active]
1271752004035	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1271752004036	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1271752004037	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1271752004038	DNA binding residues [nucleotide binding]
1271752004039	YceI-like domain; Region: YceI; pfam04264
1271752004040	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1271752004041	active site
1271752004042	homotetramer interface [polypeptide binding]; other site
1271752004043	Domain of unknown function (DUF336); Region: DUF336; cl01249
1271752004044	Domain of unknown function (DUF336); Region: DUF336; cl01249
1271752004045	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1271752004046	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1271752004047	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1271752004048	G1 box; other site
1271752004049	GTP/Mg2+ binding site [chemical binding]; other site
1271752004050	Switch I region; other site
1271752004051	G2 box; other site
1271752004052	Switch II region; other site
1271752004053	G3 box; other site
1271752004054	G4 box; other site
1271752004055	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1271752004056	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1271752004057	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1271752004058	ligand binding site [chemical binding]; other site
1271752004059	flexible hinge region; other site
1271752004060	aspartate aminotransferase; Provisional; Region: PRK05764
1271752004061	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1271752004062	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752004063	homodimer interface [polypeptide binding]; other site
1271752004064	catalytic residue [active]
1271752004065	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1271752004066	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1271752004067	dimer interface [polypeptide binding]; other site
1271752004068	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1271752004069	catalytic triad [active]
1271752004070	peroxidatic and resolving cysteines [active]
1271752004071	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1271752004072	catalytic residues [active]
1271752004073	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
1271752004074	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1271752004075	KpsF/GutQ family protein; Region: kpsF; TIGR00393
1271752004076	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1271752004077	putative active site [active]
1271752004078	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1271752004079	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1271752004080	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1271752004081	ATP binding site [chemical binding]; other site
1271752004082	putative Mg++ binding site [ion binding]; other site
1271752004083	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1271752004084	nucleotide binding region [chemical binding]; other site
1271752004085	ATP-binding site [chemical binding]; other site
1271752004086	RQC domain; Region: RQC; pfam09382
1271752004087	HRDC domain; Region: HRDC; pfam00570
1271752004088	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1271752004089	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1271752004090	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1271752004091	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
1271752004092	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
1271752004093	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
1271752004094	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
1271752004095	Protein of unknown function (DUF3308); Region: DUF3308; cl14675
1271752004096	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258
1271752004097	active site
1271752004098	FlgD Ig-like domain; Region: FlgD_ig; pfam13860
1271752004099	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
1271752004100	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1271752004101	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
1271752004102	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1271752004103	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1271752004104	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1271752004105	nudix motif; other site
1271752004106	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1271752004107	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
1271752004108	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1271752004109	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
1271752004110	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1271752004111	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1271752004112	phosphorylation site [posttranslational modification]
1271752004113	dimer interface [polypeptide binding]; other site
1271752004114	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1271752004115	ATP binding site [chemical binding]; other site
1271752004116	Mg2+ binding site [ion binding]; other site
1271752004117	G-X-G motif; other site
1271752004118	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1271752004119	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1271752004120	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1271752004121	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1271752004122	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1271752004123	ligand binding site [chemical binding]; other site
1271752004124	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
1271752004125	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1271752004126	FAD binding domain; Region: FAD_binding_4; pfam01565
1271752004127	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1271752004128	active site
1271752004129	oxyanion hole [active]
1271752004130	catalytic triad [active]
1271752004131	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1271752004132	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1271752004133	active site
1271752004134	GTPase CgtA; Reviewed; Region: obgE; PRK12299
1271752004135	GTP1/OBG; Region: GTP1_OBG; pfam01018
1271752004136	Obg GTPase; Region: Obg; cd01898
1271752004137	G1 box; other site
1271752004138	GTP/Mg2+ binding site [chemical binding]; other site
1271752004139	Switch I region; other site
1271752004140	G2 box; other site
1271752004141	G3 box; other site
1271752004142	Switch II region; other site
1271752004143	G4 box; other site
1271752004144	G5 box; other site
1271752004145	adenylate kinase; Reviewed; Region: adk; PRK00279
1271752004146	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1271752004147	AMP-binding site [chemical binding]; other site
1271752004148	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1271752004149	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1271752004150	active site
1271752004151	CAAX protease self-immunity; Region: Abi; pfam02517
1271752004152	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1271752004153	active site
1271752004154	dimerization interface [polypeptide binding]; other site
1271752004155	ribonuclease Z; Reviewed; Region: PRK00055
1271752004156	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
1271752004157	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1271752004158	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1271752004159	active site
1271752004160	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
1271752004161	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1271752004162	dimer interface [polypeptide binding]; other site
1271752004163	active site
1271752004164	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1271752004165	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1271752004166	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1271752004167	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1271752004168	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1271752004169	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1271752004170	substrate binding site [chemical binding]; other site
1271752004171	oxyanion hole (OAH) forming residues; other site
1271752004172	trimer interface [polypeptide binding]; other site
1271752004173	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1271752004174	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1271752004175	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1271752004176	active site
1271752004177	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1271752004178	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1271752004179	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1271752004180	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
1271752004181	NAD(P) binding site [chemical binding]; other site
1271752004182	active site
1271752004183	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1271752004184	active site
1271752004185	intersubunit interactions; other site
1271752004186	catalytic residue [active]
1271752004187	GTP-binding protein YchF; Reviewed; Region: PRK09601
1271752004188	YchF GTPase; Region: YchF; cd01900
1271752004189	G1 box; other site
1271752004190	GTP/Mg2+ binding site [chemical binding]; other site
1271752004191	Switch I region; other site
1271752004192	G2 box; other site
1271752004193	Switch II region; other site
1271752004194	G3 box; other site
1271752004195	G4 box; other site
1271752004196	G5 box; other site
1271752004197	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1271752004198	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
1271752004199	Membrane protein of unknown function; Region: DUF360; pfam04020
1271752004200	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
1271752004201	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1271752004202	dimer interface [polypeptide binding]; other site
1271752004203	active site
1271752004204	CoA binding pocket [chemical binding]; other site
1271752004205	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1271752004206	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1271752004207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1271752004208	S-adenosylmethionine binding site [chemical binding]; other site
1271752004209	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
1271752004210	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
1271752004211	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
1271752004212	starch binding outer membrane protein SusD; Region: SusD; cl17845
1271752004213	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
1271752004214	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
1271752004215	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
1271752004216	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1271752004217	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1271752004218	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
1271752004219	tetramer interface [polypeptide binding]; other site
1271752004220	heme binding pocket [chemical binding]; other site
1271752004221	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1271752004222	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1271752004223	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1271752004224	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1271752004225	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1271752004226	phosphodiesterase YaeI; Provisional; Region: PRK11340
1271752004227	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1271752004228	putative active site [active]
1271752004229	putative metal binding site [ion binding]; other site
1271752004230	Transglycosylase; Region: Transgly; cl17702
1271752004231	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
1271752004232	Site-specific recombinase; Region: SpecificRecomb; cl15411
1271752004233	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
1271752004234	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1271752004235	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1271752004236	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
1271752004237	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1271752004238	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1271752004239	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1271752004240	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1271752004241	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1271752004242	protein binding site [polypeptide binding]; other site
1271752004243	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
1271752004244	Domain interface; other site
1271752004245	Peptide binding site; other site
1271752004246	Active site tetrad [active]
1271752004247	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
1271752004248	starch binding outer membrane protein SusD; Region: SusD; cd08977
1271752004249	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
1271752004250	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1271752004251	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1271752004252	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1271752004253	dimer interface [polypeptide binding]; other site
1271752004254	active site
1271752004255	catalytic residue [active]
1271752004256	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1271752004257	Uncharacterized subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u3; cd12832
1271752004258	oligomer interface [polypeptide binding]; other site
1271752004259	metal binding site [ion binding]; metal-binding site
1271752004260	putative Cl binding site [ion binding]; other site
1271752004261	basic sphincter; other site
1271752004262	hydrophobic gate; other site
1271752004263	periplasmic entrance; other site
1271752004264	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1271752004265	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1271752004266	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1271752004267	FeoA domain; Region: FeoA; pfam04023
1271752004268	NAD-dependent deacetylase; Provisional; Region: PRK00481
1271752004269	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
1271752004270	NAD+ binding site [chemical binding]; other site
1271752004271	substrate binding site [chemical binding]; other site
1271752004272	Zn binding site [ion binding]; other site
1271752004273	Isochorismatase family; Region: Isochorismatase; pfam00857
1271752004274	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1271752004275	catalytic triad [active]
1271752004276	conserved cis-peptide bond; other site
1271752004277	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1271752004278	MgtE intracellular N domain; Region: MgtE_N; smart00924
1271752004279	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1271752004280	Divalent cation transporter; Region: MgtE; pfam01769
1271752004281	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1271752004282	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1271752004283	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1271752004284	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1271752004285	FtsX-like permease family; Region: FtsX; pfam02687
1271752004286	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
1271752004287	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1271752004288	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1271752004289	UGMP family protein; Validated; Region: PRK09604
1271752004290	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1271752004291	Family of unknown function (DUF490); Region: DUF490; pfam04357
1271752004292	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
1271752004293	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1271752004294	putative DNA binding site [nucleotide binding]; other site
1271752004295	putative Zn2+ binding site [ion binding]; other site
1271752004296	AsnC family; Region: AsnC_trans_reg; pfam01037
1271752004297	Rrf2 family protein; Region: rrf2_super; TIGR00738
1271752004298	Transcriptional regulator; Region: Rrf2; pfam02082
1271752004299	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
1271752004300	putative SAM binding site [chemical binding]; other site
1271752004301	homodimer interface [polypeptide binding]; other site
1271752004302	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1271752004303	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1271752004304	active site
1271752004305	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1271752004306	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1271752004307	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752004308	Walker A motif; other site
1271752004309	ATP binding site [chemical binding]; other site
1271752004310	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1271752004311	Walker B motif; other site
1271752004312	arginine finger; other site
1271752004313	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1271752004314	DnaA box-binding interface [nucleotide binding]; other site
1271752004315	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1271752004316	active site
1271752004317	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
1271752004318	active site pocket [active]
1271752004319	oxyanion hole [active]
1271752004320	catalytic triad [active]
1271752004321	active site nucleophile [active]
1271752004322	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
1271752004323	amino acid transporter; Region: 2A0306; TIGR00909
1271752004324	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1271752004325	HD domain; Region: HD_4; pfam13328
1271752004326	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1271752004327	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1271752004328	RNA binding surface [nucleotide binding]; other site
1271752004329	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
1271752004330	probable active site [active]
1271752004331	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1271752004332	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
1271752004333	RNA binding site [nucleotide binding]; other site
1271752004334	active site
1271752004335	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1271752004336	putative nucleotide binding site [chemical binding]; other site
1271752004337	uridine monophosphate binding site [chemical binding]; other site
1271752004338	homohexameric interface [polypeptide binding]; other site
1271752004339	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1271752004340	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1271752004341	hinge region; other site
1271752004342	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1271752004343	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1271752004344	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1271752004345	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1271752004346	GH3 auxin-responsive promoter; Region: GH3; pfam03321
1271752004347	H+ Antiporter protein; Region: 2A0121; TIGR00900
1271752004348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1271752004349	putative substrate translocation pore; other site
1271752004350	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1271752004351	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1271752004352	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1271752004353	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
1271752004354	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1271752004355	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
1271752004356	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
1271752004357	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1271752004358	TrkA-N domain; Region: TrkA_N; pfam02254
1271752004359	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1271752004360	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1271752004361	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1271752004362	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1271752004363	DNA binding residues [nucleotide binding]
1271752004364	nucleoside transporter; Region: 2A0110; TIGR00889
1271752004365	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1271752004366	putative substrate translocation pore; other site
1271752004367	Bifunctional nuclease; Region: DNase-RNase; pfam02577
1271752004368	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1271752004369	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
1271752004370	Ligand binding site [chemical binding]; other site
1271752004371	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1271752004372	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1271752004373	Ligand binding site [chemical binding]; other site
1271752004374	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1271752004375	short chain dehydrogenase; Provisional; Region: PRK07326
1271752004376	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1271752004377	NAD(P) binding site [chemical binding]; other site
1271752004378	active site
1271752004379	Protein of unknown function (DUF3822); Region: DUF3822; pfam12864
1271752004380	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1271752004381	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1271752004382	S-adenosylmethionine binding site [chemical binding]; other site
1271752004383	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1271752004384	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1271752004385	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1271752004386	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752004387	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1271752004388	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1271752004389	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1271752004390	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1271752004391	Walker A/P-loop; other site
1271752004392	ATP binding site [chemical binding]; other site
1271752004393	Q-loop/lid; other site
1271752004394	ABC transporter signature motif; other site
1271752004395	Walker B; other site
1271752004396	D-loop; other site
1271752004397	H-loop/switch region; other site
1271752004398	lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598
1271752004399	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1271752004400	Sulfatase; Region: Sulfatase; pfam00884
1271752004401	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1271752004402	active site
1271752004403	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1271752004404	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1271752004405	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1271752004406	hexamer interface [polypeptide binding]; other site
1271752004407	ligand binding site [chemical binding]; other site
1271752004408	putative active site [active]
1271752004409	NAD(P) binding site [chemical binding]; other site
1271752004410	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
1271752004411	prephenate dehydrogenase; Validated; Region: PRK08507
1271752004412	Prephenate dehydrogenase; Region: PDH; pfam02153
1271752004413	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1271752004414	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1271752004415	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1271752004416	TrkA-N domain; Region: TrkA_N; pfam02254
1271752004417	TrkA-C domain; Region: TrkA_C; pfam02080
1271752004418	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1271752004419	putative active site [active]
1271752004420	putative CoA binding site [chemical binding]; other site
1271752004421	nudix motif; other site
1271752004422	metal binding site [ion binding]; metal-binding site
1271752004423	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1271752004424	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1271752004425	putative acyl-acceptor binding pocket; other site
1271752004426	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1271752004427	recombination factor protein RarA; Reviewed; Region: PRK13342
1271752004428	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752004429	Walker A motif; other site
1271752004430	ATP binding site [chemical binding]; other site
1271752004431	Walker B motif; other site
1271752004432	arginine finger; other site
1271752004433	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1271752004434	Haemolytic domain; Region: Haemolytic; pfam01809
1271752004435	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1271752004436	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1271752004437	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1271752004438	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1271752004439	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1271752004440	catalytic residue [active]
1271752004441	Response regulator receiver domain; Region: Response_reg; pfam00072
1271752004442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1271752004443	active site
1271752004444	phosphorylation site [posttranslational modification]
1271752004445	intermolecular recognition site; other site
1271752004446	dimerization interface [polypeptide binding]; other site
1271752004447	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752004448	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1271752004449	Walker A motif; other site
1271752004450	ATP binding site [chemical binding]; other site
1271752004451	Walker B motif; other site
1271752004452	arginine finger; other site
1271752004453	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1271752004454	multidrug efflux protein; Reviewed; Region: PRK01766
1271752004455	cation binding site [ion binding]; other site
1271752004456	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1271752004457	PCRF domain; Region: PCRF; pfam03462
1271752004458	RF-1 domain; Region: RF-1; pfam00472
1271752004459	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1271752004460	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1271752004461	DNA primase, catalytic core; Region: dnaG; TIGR01391
1271752004462	CHC2 zinc finger; Region: zf-CHC2; cl17510
1271752004463	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1271752004464	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1271752004465	active site
1271752004466	metal binding site [ion binding]; metal-binding site
1271752004467	interdomain interaction site; other site
1271752004468	Clp protease; Region: CLP_protease; pfam00574
1271752004469	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1271752004470	oligomer interface [polypeptide binding]; other site
1271752004471	active site residues [active]
1271752004472	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
1271752004473	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
1271752004474	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752004475	Walker A motif; other site
1271752004476	ATP binding site [chemical binding]; other site
1271752004477	Walker B motif; other site
1271752004478	arginine finger; other site
1271752004479	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
1271752004480	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861
1271752004481	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1271752004482	metal binding triad [ion binding]; metal-binding site
1271752004483	Restriction endonuclease; Region: Mrr_cat; pfam04471
1271752004484	PIN domain; Region: PIN_3; cl17397
1271752004485	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
1271752004486	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
1271752004487	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1271752004488	oligomeric interface; other site
1271752004489	putative active site [active]
1271752004490	homodimer interface [polypeptide binding]; other site
1271752004491	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
1271752004492	Sel1 repeat; Region: Sel1; cl02723
1271752004493	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1271752004494	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1271752004495	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752004496	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1271752004497	DNA methylase; Region: N6_N4_Mtase; pfam01555
1271752004498	DpnII restriction endonuclease; Region: DpnII; pfam04556
1271752004499	DNA adenine methylase (dam); Region: dam; TIGR00571
1271752004500	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1271752004501	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
1271752004502	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1271752004503	non-specific DNA binding site [nucleotide binding]; other site
1271752004504	salt bridge; other site
1271752004505	sequence-specific DNA binding site [nucleotide binding]; other site
1271752004506	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
1271752004507	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1271752004508	synthetase active site [active]
1271752004509	metal binding site [ion binding]; metal-binding site
1271752004510	NTP binding site [chemical binding]; other site
1271752004511	Heavy-metal-associated domain; Region: HMA; pfam00403
1271752004512	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1271752004513	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1271752004514	non-specific DNA binding site [nucleotide binding]; other site
1271752004515	salt bridge; other site
1271752004516	sequence-specific DNA binding site [nucleotide binding]; other site
1271752004517	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
1271752004518	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
1271752004519	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1271752004520	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1271752004521	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1271752004522	Helix-turn-helix domain; Region: HTH_18; pfam12833
1271752004523	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1271752004524	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
1271752004525	metal-binding site [ion binding]
1271752004526	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
1271752004527	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752004528	Heavy-metal-associated domain; Region: HMA; pfam00403
1271752004529	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1271752004530	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1271752004531	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
1271752004532	hypothetical protein; Provisional; Region: PRK07236
1271752004533	hypothetical protein; Validated; Region: PRK05868
1271752004534	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1271752004535	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1271752004536	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1271752004537	active site
1271752004538	substrate binding site [chemical binding]; other site
1271752004539	trimer interface [polypeptide binding]; other site
1271752004540	CoA binding site [chemical binding]; other site
1271752004541	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1271752004542	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1271752004543	folate binding site [chemical binding]; other site
1271752004544	NADP+ binding site [chemical binding]; other site
1271752004545	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1271752004546	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1271752004547	active site
1271752004548	substrate binding site [chemical binding]; other site
1271752004549	trimer interface [polypeptide binding]; other site
1271752004550	CoA binding site [chemical binding]; other site
1271752004551	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
1271752004552	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1271752004553	hypothetical protein; Provisional; Region: PRK07236
1271752004554	hypothetical protein; Validated; Region: PRK05868
1271752004555	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1271752004556	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
1271752004557	Sel1 repeat; Region: Sel1; cl02723
1271752004558	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1271752004559	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1271752004560	non-specific DNA binding site [nucleotide binding]; other site
1271752004561	salt bridge; other site
1271752004562	sequence-specific DNA binding site [nucleotide binding]; other site
1271752004563	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
1271752004564	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1271752004565	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1271752004566	GLPGLI family protein; Region: GLPGLI; TIGR01200
1271752004567	aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340
1271752004568	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584
1271752004569	substrate binding site [chemical binding]; other site
1271752004570	ligand binding site [chemical binding]; other site
1271752004571	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
1271752004572	substrate binding site [chemical binding]; other site
1271752004573	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1271752004574	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
1271752004575	active site
1271752004576	NTP binding site [chemical binding]; other site
1271752004577	metal binding triad [ion binding]; metal-binding site
1271752004578	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1271752004579	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1271752004580	Zn2+ binding site [ion binding]; other site
1271752004581	Mg2+ binding site [ion binding]; other site
1271752004582	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1271752004583	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1271752004584	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1271752004585	S-adenosylmethionine binding site [chemical binding]; other site
1271752004586	The C-terminal domain of uncharacterized bacterial proteins; Region: Bvu_2165_C_like; cd12843
1271752004587	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
1271752004588	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
1271752004589	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
1271752004590	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1271752004591	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
1271752004592	inhibitor-cofactor binding pocket; inhibition site
1271752004593	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752004594	catalytic residue [active]
1271752004595	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1271752004596	AAA domain; Region: AAA_26; pfam13500
1271752004597	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1271752004598	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1271752004599	catalytic residue [active]
1271752004600	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1271752004601	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1271752004602	active site
1271752004603	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1271752004604	FAD binding site [chemical binding]; other site
1271752004605	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
1271752004606	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1271752004607	substrate binding pocket [chemical binding]; other site
1271752004608	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1271752004609	B12 binding site [chemical binding]; other site
1271752004610	cobalt ligand [ion binding]; other site
1271752004611	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1271752004612	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1271752004613	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1271752004614	Proline dehydrogenase; Region: Pro_dh; cl03282
1271752004615	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1271752004616	active site
1271752004617	dimer interface [polypeptide binding]; other site
1271752004618	metal binding site [ion binding]; metal-binding site
1271752004619	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
1271752004620	Oxygen tolerance; Region: BatD; pfam13584
1271752004621	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1271752004622	binding surface
1271752004623	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1271752004624	TPR motif; other site
1271752004625	TPR repeat; Region: TPR_11; pfam13414
1271752004626	von Willebrand factor type A domain; Region: VWA_2; pfam13519
1271752004627	metal ion-dependent adhesion site (MIDAS); other site
1271752004628	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1271752004629	metal ion-dependent adhesion site (MIDAS); other site
1271752004630	Oxygen tolerance; Region: BatD; pfam13584
1271752004631	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1271752004632	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1271752004633	metal ion-dependent adhesion site (MIDAS); other site
1271752004634	MoxR-like ATPases [General function prediction only]; Region: COG0714
1271752004635	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752004636	Walker A motif; other site
1271752004637	ATP binding site [chemical binding]; other site
1271752004638	Walker B motif; other site
1271752004639	arginine finger; other site
1271752004640	DinB superfamily; Region: DinB_2; pfam12867
1271752004641	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1271752004642	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1271752004643	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1271752004644	TraB family; Region: TraB; cl12050
1271752004645	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1271752004646	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
1271752004647	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1271752004648	Substrate binding site [chemical binding]; other site
1271752004649	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1271752004650	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752004651	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1271752004652	N-terminal plug; other site
1271752004653	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
1271752004654	ligand-binding site [chemical binding]; other site
1271752004655	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
1271752004656	Imelysin; Region: Peptidase_M75; pfam09375
1271752004657	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752004658	Domain of unknown function (DUF4302); Region: DUF4302; pfam14135
1271752004659	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
1271752004660	starch binding outer membrane protein SusD; Region: SusD; cl17845
1271752004661	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
1271752004662	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
1271752004663	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752004664	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1271752004665	amino acid transporter; Region: 2A0306; TIGR00909
1271752004666	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1271752004667	Predicted transcriptional regulator [Transcription]; Region: COG2378
1271752004668	WYL domain; Region: WYL; pfam13280
1271752004669	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
1271752004670	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1271752004671	tetramer interface [polypeptide binding]; other site
1271752004672	TPP-binding site [chemical binding]; other site
1271752004673	heterodimer interface [polypeptide binding]; other site
1271752004674	phosphorylation loop region [posttranslational modification]
1271752004675	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1271752004676	E3 interaction surface; other site
1271752004677	lipoyl attachment site [posttranslational modification]; other site
1271752004678	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1271752004679	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1271752004680	E3 interaction surface; other site
1271752004681	lipoyl attachment site [posttranslational modification]; other site
1271752004682	e3 binding domain; Region: E3_binding; pfam02817
1271752004683	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1271752004684	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1271752004685	intersubunit interface [polypeptide binding]; other site
1271752004686	active site
1271752004687	catalytic residue [active]
1271752004688	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1271752004689	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1271752004690	putative substrate translocation pore; other site
1271752004691	POT family; Region: PTR2; cl17359
1271752004692	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1271752004693	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
1271752004694	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
1271752004695	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
1271752004696	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1271752004697	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
1271752004698	SusD family; Region: SusD; pfam07980
1271752004699	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577
1271752004700	putative active site [active]
1271752004701	catalytic site [active]
1271752004702	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
1271752004703	active site
1271752004704	dimer interface [polypeptide binding]; other site
1271752004705	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
1271752004706	putative catalytic site [active]
1271752004707	putative metal binding site [ion binding]; other site
1271752004708	putative phosphate binding site [ion binding]; other site
1271752004709	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
1271752004710	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
1271752004711	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1271752004712	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1271752004713	ATP binding site [chemical binding]; other site
1271752004714	putative Mg++ binding site [ion binding]; other site
1271752004715	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1271752004716	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1271752004717	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1271752004718	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1271752004719	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1271752004720	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1271752004721	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1271752004722	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1271752004723	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1271752004724	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1271752004725	ATP binding site [chemical binding]; other site
1271752004726	putative Mg++ binding site [ion binding]; other site
1271752004727	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
1271752004728	Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690
1271752004729	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1271752004730	GAF domain; Region: GAF_2; pfam13185
1271752004731	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1271752004732	putative hydrolase; Provisional; Region: PRK02113
1271752004733	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
1271752004734	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1271752004735	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1271752004736	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1271752004737	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1271752004738	inhibitor-cofactor binding pocket; inhibition site
1271752004739	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752004740	catalytic residue [active]
1271752004741	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1271752004742	LysM domain; Region: LysM; pfam01476
1271752004743	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1271752004744	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
1271752004745	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1271752004746	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1271752004747	catalytic residue [active]
1271752004748	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
1271752004749	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
1271752004750	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1271752004751	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1271752004752	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1271752004753	ligand binding site [chemical binding]; other site
1271752004754	active site
1271752004755	UGI interface [polypeptide binding]; other site
1271752004756	catalytic site [active]
1271752004757	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
1271752004758	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1271752004759	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
1271752004760	homodimer interface [polypeptide binding]; other site
1271752004761	substrate-cofactor binding pocket; other site
1271752004762	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752004763	catalytic residue [active]
1271752004764	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1271752004765	active site
1271752004766	multimer interface [polypeptide binding]; other site
1271752004767	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1271752004768	gamma subunit interface [polypeptide binding]; other site
1271752004769	LBP interface [polypeptide binding]; other site
1271752004770	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1271752004771	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1271752004772	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1271752004773	alpha subunit interaction interface [polypeptide binding]; other site
1271752004774	Walker A motif; other site
1271752004775	ATP binding site [chemical binding]; other site
1271752004776	Walker B motif; other site
1271752004777	inhibitor binding site; inhibition site
1271752004778	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1271752004779	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1271752004780	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1271752004781	active site
1271752004782	Riboflavin kinase; Region: Flavokinase; pfam01687
1271752004783	Protein of unknown function (DUF419); Region: DUF419; pfam04237
1271752004784	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1271752004785	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
1271752004786	putative active site [active]
1271752004787	Mn binding site [ion binding]; other site
1271752004788	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1271752004789	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1271752004790	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
1271752004791	dimer interface [polypeptide binding]; other site
1271752004792	active site
1271752004793	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1271752004794	catalytic residues [active]
1271752004795	substrate binding site [chemical binding]; other site
1271752004796	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
1271752004797	Thiamine pyrophosphokinase; Region: TPK; cd07995
1271752004798	active site
1271752004799	dimerization interface [polypeptide binding]; other site
1271752004800	thiamine binding site [chemical binding]; other site
1271752004801	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
1271752004802	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1271752004803	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1271752004804	Walker A/P-loop; other site
1271752004805	ATP binding site [chemical binding]; other site
1271752004806	Q-loop/lid; other site
1271752004807	ABC transporter signature motif; other site
1271752004808	Walker B; other site
1271752004809	D-loop; other site
1271752004810	H-loop/switch region; other site
1271752004811	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1271752004812	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1271752004813	ligand binding site [chemical binding]; other site
1271752004814	flexible hinge region; other site
1271752004815	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1271752004816	non-specific DNA interactions [nucleotide binding]; other site
1271752004817	DNA binding site [nucleotide binding]
1271752004818	sequence specific DNA binding site [nucleotide binding]; other site
1271752004819	putative cAMP binding site [chemical binding]; other site
1271752004820	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1271752004821	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1271752004822	CoenzymeA binding site [chemical binding]; other site
1271752004823	subunit interaction site [polypeptide binding]; other site
1271752004824	PHB binding site; other site
1271752004825	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1271752004826	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1271752004827	putative acyl-acceptor binding pocket; other site
1271752004828	PspC domain; Region: PspC; pfam04024
1271752004829	Invasion gene expression up-regulator, SirB; Region: SirB; cl01184
1271752004830	Predicted transcriptional regulators [Transcription]; Region: COG1695
1271752004831	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1271752004832	putative Zn2+ binding site [ion binding]; other site
1271752004833	putative DNA binding site [nucleotide binding]; other site
1271752004834	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1271752004835	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1271752004836	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1271752004837	Thioesterase domain; Region: Thioesterase; pfam00975
1271752004838	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1271752004839	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1271752004840	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752004841	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1271752004842	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1271752004843	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1271752004844	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1271752004845	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1271752004846	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1271752004847	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1271752004848	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
1271752004849	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1271752004850	Flavodoxin; Region: Flavodoxin_1; pfam00258
1271752004851	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1271752004852	FAD binding pocket [chemical binding]; other site
1271752004853	conserved FAD binding motif [chemical binding]; other site
1271752004854	phosphate binding motif [ion binding]; other site
1271752004855	beta-alpha-beta structure motif; other site
1271752004856	NAD binding pocket [chemical binding]; other site
1271752004857	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1271752004858	ApbE family; Region: ApbE; pfam02424
1271752004859	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1271752004860	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1271752004861	Rrf2 family protein; Region: rrf2_super; TIGR00738
1271752004862	Transcriptional regulator; Region: Rrf2; pfam02082
1271752004863	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
1271752004864	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1271752004865	Hemerythrin-like domain; Region: Hr-like; cd12108
1271752004866	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1271752004867	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1271752004868	ligand binding site [chemical binding]; other site
1271752004869	flexible hinge region; other site
1271752004870	Domain of unknown function DUF77; Region: DUF77; cl00307
1271752004871	Cytochrome c; Region: Cytochrom_C; cl11414
1271752004872	Cytochrome c; Region: Cytochrom_C; pfam00034
1271752004873	nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246
1271752004874	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1271752004875	NosL; Region: NosL; cl01769
1271752004876	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
1271752004877	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1271752004878	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1271752004879	Walker A/P-loop; other site
1271752004880	ATP binding site [chemical binding]; other site
1271752004881	Q-loop/lid; other site
1271752004882	ABC transporter signature motif; other site
1271752004883	Walker B; other site
1271752004884	D-loop; other site
1271752004885	H-loop/switch region; other site
1271752004886	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cl00178
1271752004887	secondary substrate binding site; other site
1271752004888	primary substrate binding site; other site
1271752004889	inhibition loop; other site
1271752004890	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1271752004891	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1271752004892	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1271752004893	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1271752004894	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1271752004895	DNA binding residues [nucleotide binding]
1271752004896	Pirin-related protein [General function prediction only]; Region: COG1741
1271752004897	Pirin; Region: Pirin; pfam02678
1271752004898	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1271752004899	Response regulator receiver domain; Region: Response_reg; pfam00072
1271752004900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1271752004901	active site
1271752004902	phosphorylation site [posttranslational modification]
1271752004903	intermolecular recognition site; other site
1271752004904	dimerization interface [polypeptide binding]; other site
1271752004905	PglZ domain; Region: PglZ; pfam08665
1271752004906	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1271752004907	catalytic motif [active]
1271752004908	Zn binding site [ion binding]; other site
1271752004909	RibD C-terminal domain; Region: RibD_C; cl17279
1271752004910	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1271752004911	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1271752004912	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1271752004913	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1271752004914	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1271752004915	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1271752004916	shikimate binding site; other site
1271752004917	NAD(P) binding site [chemical binding]; other site
1271752004918	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1271752004919	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1271752004920	homodimer interface [polypeptide binding]; other site
1271752004921	metal binding site [ion binding]; metal-binding site
1271752004922	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1271752004923	homodimer interface [polypeptide binding]; other site
1271752004924	active site
1271752004925	putative chemical substrate binding site [chemical binding]; other site
1271752004926	metal binding site [ion binding]; metal-binding site
1271752004927	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1271752004928	active site
1271752004929	catalytic residues [active]
1271752004930	metal binding site [ion binding]; metal-binding site
1271752004931	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
1271752004932	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1271752004933	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
1271752004934	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1271752004935	ATP binding site [chemical binding]; other site
1271752004936	putative Mg++ binding site [ion binding]; other site
1271752004937	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1271752004938	nucleotide binding region [chemical binding]; other site
1271752004939	ATP-binding site [chemical binding]; other site
1271752004940	TRCF domain; Region: TRCF; pfam03461
1271752004941	YceI-like domain; Region: YceI; pfam04264
1271752004942	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1271752004943	dimer interface [polypeptide binding]; other site
1271752004944	phosphorylation site [posttranslational modification]
1271752004945	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1271752004946	ATP binding site [chemical binding]; other site
1271752004947	Mg2+ binding site [ion binding]; other site
1271752004948	G-X-G motif; other site
1271752004949	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1271752004950	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1271752004951	active site
1271752004952	phosphorylation site [posttranslational modification]
1271752004953	intermolecular recognition site; other site
1271752004954	dimerization interface [polypeptide binding]; other site
1271752004955	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1271752004956	DNA binding site [nucleotide binding]
1271752004957	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1271752004958	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1271752004959	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752004960	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1271752004961	gliding motility associated protien GldN; Region: GldN; TIGR03523
1271752004962	gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517
1271752004963	GldM N-terminal domain; Region: GldM_N; pfam12081
1271752004964	GldM C-terminal domain; Region: GldM_C; pfam12080
1271752004965	gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513
1271752004966	gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525
1271752004967	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1271752004968	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1271752004969	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1271752004970	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1271752004971	glutaminase active site [active]
1271752004972	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1271752004973	dimer interface [polypeptide binding]; other site
1271752004974	active site
1271752004975	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1271752004976	dimer interface [polypeptide binding]; other site
1271752004977	active site
1271752004978	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
1271752004979	Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323
1271752004980	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1271752004981	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1271752004982	active site
1271752004983	ATP-binding site [chemical binding]; other site
1271752004984	pantoate-binding site; other site
1271752004985	HXXH motif; other site
1271752004986	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
1271752004987	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
1271752004988	HemN C-terminal domain; Region: HemN_C; pfam06969
1271752004989	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
1271752004990	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1271752004991	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1271752004992	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1271752004993	dimer interface [polypeptide binding]; other site
1271752004994	motif 1; other site
1271752004995	active site
1271752004996	motif 2; other site
1271752004997	motif 3; other site
1271752004998	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1271752004999	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1271752005000	Walker A/P-loop; other site
1271752005001	ATP binding site [chemical binding]; other site
1271752005002	Q-loop/lid; other site
1271752005003	ABC transporter signature motif; other site
1271752005004	Walker B; other site
1271752005005	D-loop; other site
1271752005006	H-loop/switch region; other site
1271752005007	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1271752005008	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1271752005009	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1271752005010	Walker A/P-loop; other site
1271752005011	ATP binding site [chemical binding]; other site
1271752005012	Q-loop/lid; other site
1271752005013	ABC transporter signature motif; other site
1271752005014	Walker B; other site
1271752005015	D-loop; other site
1271752005016	H-loop/switch region; other site
1271752005017	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1271752005018	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1271752005019	dimerization interface 3.5A [polypeptide binding]; other site
1271752005020	active site
1271752005021	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1271752005022	active site
1271752005023	metal binding site [ion binding]; metal-binding site
1271752005024	homotetramer interface [polypeptide binding]; other site
1271752005025	Smr domain; Region: Smr; cl02619
1271752005026	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1271752005027	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1271752005028	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1271752005029	dimer interface [polypeptide binding]; other site
1271752005030	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752005031	catalytic residue [active]
1271752005032	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1271752005033	trimer interface [polypeptide binding]; other site
1271752005034	active site
1271752005035	substrate binding site [chemical binding]; other site
1271752005036	CoA binding site [chemical binding]; other site
1271752005037	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1271752005038	gliding motility-associated protein GldC; Region: GldC; TIGR03515
1271752005039	gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514
1271752005040	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1271752005041	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1271752005042	homodimer interface [polypeptide binding]; other site
1271752005043	NAD binding pocket [chemical binding]; other site
1271752005044	ATP binding pocket [chemical binding]; other site
1271752005045	Mg binding site [ion binding]; other site
1271752005046	active-site loop [active]
1271752005047	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
1271752005048	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
1271752005049	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1271752005050	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
1271752005051	inhibitor-cofactor binding pocket; inhibition site
1271752005052	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752005053	catalytic residue [active]
1271752005054	OstA-like protein; Region: OstA; cl00844
1271752005055	OstA-like protein; Region: OstA_2; pfam13100
1271752005056	OstA-like protein; Region: OstA; cl00844
1271752005057	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1271752005058	metal binding site 2 [ion binding]; metal-binding site
1271752005059	putative DNA binding helix; other site
1271752005060	metal binding site 1 [ion binding]; metal-binding site
1271752005061	dimer interface [polypeptide binding]; other site
1271752005062	structural Zn2+ binding site [ion binding]; other site
1271752005063	K+ potassium transporter; Region: K_trans; pfam02705
1271752005064	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
1271752005065	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1271752005066	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
1271752005067	active site
1271752005068	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
1271752005069	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1271752005070	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1271752005071	putative substrate translocation pore; other site
1271752005072	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1271752005073	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752005074	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1271752005075	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1271752005076	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1271752005077	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1271752005078	nucleotide binding pocket [chemical binding]; other site
1271752005079	K-X-D-G motif; other site
1271752005080	catalytic site [active]
1271752005081	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1271752005082	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1271752005083	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1271752005084	Dimer interface [polypeptide binding]; other site
1271752005085	BRCT sequence motif; other site
1271752005086	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1271752005087	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1271752005088	non-specific DNA binding site [nucleotide binding]; other site
1271752005089	salt bridge; other site
1271752005090	sequence-specific DNA binding site [nucleotide binding]; other site
1271752005091	PspA/IM30 family; Region: PspA_IM30; pfam04012
1271752005092	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
1271752005093	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1271752005094	ATPase involved in DNA repair; Region: DUF3686; pfam12458
1271752005095	AAA domain; Region: AAA_22; pfam13401
1271752005096	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1271752005097	Walker A motif; other site
1271752005098	ATP binding site [chemical binding]; other site
1271752005099	Walker B motif; other site
1271752005100	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
1271752005101	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
1271752005102	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
1271752005103	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
1271752005104	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
1271752005105	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1271752005106	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1271752005107	RHS Repeat; Region: RHS_repeat; pfam05593
1271752005108	RHS Repeat; Region: RHS_repeat; cl11982
1271752005109	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1271752005110	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
1271752005111	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
1271752005112	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
1271752005113	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1271752005114	Peptidase family M23; Region: Peptidase_M23; pfam01551
1271752005115	Protein of unknown function (DUF2459); Region: DUF2459; pfam09601
1271752005116	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1271752005117	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
1271752005118	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1271752005119	active site residue [active]
1271752005120	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1271752005121	Coenzyme A binding pocket [chemical binding]; other site
1271752005122	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
1271752005123	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1271752005124	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1271752005125	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
1271752005126	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1271752005127	S-adenosylmethionine binding site [chemical binding]; other site
1271752005128	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1271752005129	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1271752005130	FtsX-like permease family; Region: FtsX; pfam02687
1271752005131	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
1271752005132	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
1271752005133	hypothetical protein; Provisional; Region: PRK10578
1271752005134	UPF0126 domain; Region: UPF0126; pfam03458
1271752005135	UPF0126 domain; Region: UPF0126; pfam03458
1271752005136	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1271752005137	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1271752005138	active site
1271752005139	(T/H)XGH motif; other site
1271752005140	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1271752005141	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1271752005142	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1271752005143	homoserine O-acetyltransferase; Provisional; Region: PRK06765
1271752005144	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1271752005145	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1271752005146	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
1271752005147	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1271752005148	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1271752005149	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
1271752005150	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1271752005151	homodimer interface [polypeptide binding]; other site
1271752005152	substrate-cofactor binding pocket; other site
1271752005153	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1271752005154	catalytic residue [active]
1271752005155	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1271752005156	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1271752005157	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179
1271752005158	putative ligand binding site [chemical binding]; other site
1271752005159	putative NAD binding site [chemical binding]; other site
1271752005160	catalytic site [active]
1271752005161	Beta-lactamase; Region: Beta-lactamase; pfam00144
1271752005162	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1271752005163	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1271752005164	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1271752005165	CoA-ligase; Region: Ligase_CoA; pfam00549
1271752005166	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1271752005167	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1271752005168	homodimer interface [polypeptide binding]; other site
1271752005169	catalytic residues [active]
1271752005170	NAD binding site [chemical binding]; other site
1271752005171	substrate binding pocket [chemical binding]; other site
1271752005172	flexible flap; other site
1271752005173	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
1271752005174	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1271752005175	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
1271752005176	dimerization interface [polypeptide binding]; other site
1271752005177	active site
1271752005178	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1271752005179	putative recombination protein RecB; Provisional; Region: PRK13909
1271752005180	Part of AAA domain; Region: AAA_19; pfam13245
1271752005181	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1271752005182	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1271752005183	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1271752005184	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1271752005185	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1271752005186	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1271752005187	RNA binding surface [nucleotide binding]; other site
1271752005188	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1271752005189	active site
1271752005190	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
1271752005191	starch binding outer membrane protein SusD; Region: SusD; cd08977
1271752005192	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
1271752005193	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
1271752005194	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
1271752005195	active site
1271752005196	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1271752005197	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1271752005198	homodimer interface [polypeptide binding]; other site
1271752005199	oligonucleotide binding site [chemical binding]; other site
1271752005200	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1271752005201	IHF dimer interface [polypeptide binding]; other site
1271752005202	IHF - DNA interface [nucleotide binding]; other site
1271752005203	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
1271752005204	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1271752005205	minor groove reading motif; other site
1271752005206	helix-hairpin-helix signature motif; other site
1271752005207	substrate binding pocket [chemical binding]; other site
1271752005208	active site
1271752005209	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1271752005210	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1271752005211	DNA binding and oxoG recognition site [nucleotide binding]
1271752005212	gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512
1271752005213	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1271752005214	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1271752005215	substrate binding site [chemical binding]; other site
1271752005216	ATP binding site [chemical binding]; other site
1271752005217	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1271752005218	SurA N-terminal domain; Region: SurA_N; pfam09312
1271752005219	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1271752005220	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1271752005221	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1271752005222	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1271752005223	motif 1; other site
1271752005224	active site
1271752005225	motif 2; other site
1271752005226	motif 3; other site
1271752005227	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1271752005228	glucokinase, proteobacterial type; Region: glk; TIGR00749
1271752005229	Glucokinase; Region: Glucokinase; pfam02685
1271752005230	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1271752005231	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1271752005232	The C-terminal domain of uncharacterized bacterial proteins; Region: Bvu_2165_C_like; cd12843
1271752005233	C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cd00037